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Ovarium cancer

Mark T J van Bussel, Dick Pluim, Mijke Bol, Jos H Beijnen, Jan H M Schellens, Dieta Brandsma
The diagnosis of leptomeningeal metastases (LM) of solid tumors is complicated due to low sensitivities of both magnetic resonance imaging (MRI) and cytology. MRI has a sensitivity of 76% for the diagnosis of LM and cerebrospinal fluid (CSF) cytology has a sensitivity of 44-67% at first lumbar puncture which increases to 84-91% upon second CSF sampling. Epithelial cell adhesion molecule (EpCAM) is expressed by solid tumors of epithelial origin like non-small-cell lung cancer, breast cancer or ovarium cancer...
March 2018: Journal of Neuro-oncology
Alena Hlouskova, Peter Bielik, Ondrej Bonczek, Vladimir J Balcar, Omar Šerý
AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer...
July 2017: Neuro Endocrinology Letters
M Felsinger, L Minář, V Weinberger, R Hudeček
OBJECTIVE: Analysis of radical fertility preserving surgery, oncogynaecological treatment including their pregnancy effort. DESIGN: Prospective study. SETTING: Department of Obstetrics and Gynaecology, Masaryk University and Faculty Hospital Brno. METHODS: The group of 13 patients in age fifteen to thirty-six, who underwent radical fertility preserving surgery of oncogynecological tumors (cervix, ovarium), 9 patients with ovarian cancer and 4 patients with carcinoma of cervix...
October 2015: Ceská Gynekologie
Masayuki Ando, Yoshihisa Watayou, Hideaki Ganno, Takeshi Nagahama, Akira Fukuda, Katsunori Ami, Toshiaki Kurokawa, Hidetoshi Amagasa, Jun Takasaki, Masahiro Nakamura, Keiichi Fujiya, Kuniyoshi Arai, Shikofumi Tei, Youichi Okada
A 37-year-old female, who had undergone a low anterior resection for lower rectal cancer, had been received chemotherapy (FOLFOX4, FOLFIRI) for 2 years because of right ovarian metastasis occurred and removed 9 months after the first operation. One month after 2 years of continued chemotherapy, progressive metastases happened to occur successively (rt lunge, left ovarium, liver, para-aortic lymphonode, Virchow lymphonode and bone). Right upper lobe pnemonectomy was performed first, then, peritonectomy, total hysterectomy with left oophorectomy and a partial resection of the small bowel were done...
November 2011: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Y Yonemura, Y Endo, T Yamaguchi, T Fujimura, T Obata, T Kawamura, N Nojima, I Miyazaki, T Sasaki
To clarify the mechanisms of the formation of peritoneal dissemination, a new animal model by the i.p. inoculation of highly metastatic gastric cancer cell line MKN-45-P was developed. Peritoneal dissemination with bloody ascites was found in 100% of nude mice, injected 1x10(7) MKN-45-P cells in suspension into the peritoneal cavity. By a highly sensitive method for specific detection of metastasized human tumor cells in nude mice using polymerase chain reaction, a human beta-globin-related sequence in the DNA from various parts of the peritoneum was specifically amplified and detected by gel electrophoresis and by a specific oligonucleotide probe...
April 1996: International Journal of Oncology
Keita Okubo, Shinichi Yoshioka, Kei Asukai, Tomoki Hata, Misuzu Nakanishi, Takayo Maekawa, Naoki Hama, Masaki Kashiwazaki, Masaaki Taniguchi, Masaki Tsujie, Muneharu Konishi, Kouji Yano, Takayoshi Fujimoto
This is an account of a case of primary adenocarcinoma of the small intestine with peritoneal dissemination successfully treated with chemotherapy. A 64-year-old woman was admitted with a complaint of severe abdominal distension. Abdominal computerized tomography revealed a bowel obstruction with tumor and the remarkable small bowel dilation of oral side of tumor. The tumor was found at surgery to be at the ileum 15 cm proximal from the ileocecal region. Peritoneal dissemination was recognized around the ileocecal region, so ileum partial resection was performed for the primary cancer lesion and dissemination region...
November 2010: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Azusa Yamamoto, Keiichiro Ishibashi, Yusuke Tajima, Satoshi Hatano, Toru Ishiguro, Tomonori Osawa, Norimichi Okada, Kensuke Kumamoto, Masaru Yokoyama, Norihiro Haga, Hideyuki Ishida
We herein report an extremely rare operative case of an isolated extraperitoneal metastasis of colon cancer. A female patient had undergone a sigmoidectomy for ileus due to sigmoid colon cancer when she was 40 years old. Peritoneal metastasis, 5 mm in diameter, was on the sigmoid colon mesentery and she was histologically diagnosed as Stage IV. She received fluorouracil-based adjuvant chemotherapy for 24 months. Serum CEA increased gradually from 36 months after the operation, and CT scan demonstrated bilateral ovarium tumors...
November 2010: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Masatsugu Ishii, Keiichiro Ishibashi, Jun Sobajima, Tomonori Ohsawa, Norimichi Okada, Kensuke Kumamoto, Norihiro Haga, Masaru Yokoyama, Hideyuki Ishida
Pseudo-Meigs' syndrome caused by ovarian metastasis from colorectal cancer is extremely rare. The clinical symptoms of pleural effusion and ascites that are characteristics of pseudo-Meigs' syndrome are quite similar to those of terminal-stage colon cancer. Therefore, recognizing the clinical characteristics of pseudo-Meigs' syndrome is important. We investigated the prognosis and clinicopathological factors including age, location of the primary cancer, histology, wall depth, curative degree, synchronous/metachronous, unilateral/bilateral, lymph node metastasis, peritoneal dissemination, serum CEA level, venous invasion, and lymphatic invasion, in 5 cases of pseudo-Meigs' syndrome (PM group) and compared these findings with those of 10 cases with ovarian metastasis from colorectal cancer (control group) without pseudo-Meigs' syndrome...
November 2010: Gan to Kagaku Ryoho. Cancer & Chemotherapy
György Horvath, José Chilo, Thomas Lindblad
UNLABELLED: Many cancers are detected at a late stage resulting in high mortality rates. Thus, it is essential to develop inexpensive and simple methods for early diagnosis. Detection of different malignancies using canine scent, as well as other technical methods, has been reported in peer-reviewed journals, indicating that this may represent a new diagnostic tool for malignancies. AIM: This study aims to test the detection of different volatile organic compound signals emitted by ovarian carcinoma and normal tissues...
June 2010: Future Oncology
Maurice P Zeegers, Leo J Schouten, R Alexandra Goldbohm, Piet A van den Brandt
Familial clustering of cancer is expected to occur at practically all anatomical sites. However, few studies have had sufficient size to investigate different sites simultaneously and with adjustment for confounders. We evaluated familial clustering in the Netherlands Cohort Study in which 120,852 men and women, aged 55-69 years in 1986 were followed up for 13.3 years. 14,025 Probands, 6,629 parents and 4,271 siblings were diagnosed with cancer. Relative Risks (RR) of cancer in first degree family members were calculated by using multivariable Cox regression analyses...
October 1, 2008: International Journal of Cancer. Journal International du Cancer
Tanel Laisaar, Veronika Palmiste, Tõnu Vooder, Triin Umbleja
The aim of the current study was to analyse postoperative complications and survival after video-assisted thoracoscopic (VATS) talc pleurodesis for malignant pleural effusion. All patients with morphologically proven malignant pleural effusion who underwent VATS talc pleurodesis from November 1995 to November 2002 were included in retrospective analysis. VATS was performed in general anaesthesia and 5 g of asbestos-free talc was insufflated into the pleural cavity. Postoperative pleural drainage was used until fluid output was less than 100 ml/24 h...
June 2006: Interactive Cardiovascular and Thoracic Surgery
Andrea E de Jong, Yvonne M C Hendriks, Jan H Kleibeuker, Sybrand Y de Boer, Annemieke Cats, Gerrit Griffioen, Fokko M Nagengast, Frits G Nelis, Matti A Rookus, Hans F A Vasen
BACKGROUND & AIMS: Lynch syndrome family members have a high risk of developing colorectal (CRC), endometrial (EC), and other cancers. A large-scale surveillance program was introduced in The Netherlands in the late 1980s. The aims of the study were to evaluate the effectiveness of this program by assessing mortality because of CRC and EC before and after 1990 and to compare mortality because of all cancers (except CRC/EC) with mortality in the general population. METHODS: Family members with at least 50% probability of being a carrier were selected for the study...
March 2006: Gastroenterology
Sergio G Chialina, Claudia Fornes, Carolina Landi, Carlos D de la Vega Elena, Maria V Nicolorich, Ricardo J Dourisboure, Angela Solano, Edita A Solis
BACKGROUND: Hereditary non-polyposis colon cancer (HNPCC) is an autosomal dominant syndrome predisposing to the early development of various cancers including those of colon, rectum, endometrium, ovarium, small bowel, stomach and urinary tract. HNPCC is caused by germline mutations in the DNA mismatch repair genes, mostly hMSH2 or hMLH1. In this study, we report the analysis for genetic counseling of three first-degree relatives (the mother and two sisters) of a male who died of colorectal adenocarcinoma at the age of 23...
2006: BMC Medical Genetics
Michihiko Tsubono, Iwao Kaneko, Eiji Kii, Toshiro Tanaka, Toru Murata, Kazuyasu Kamimura, Yasunori Deguchi, Hirofumi Nonogaki, Ryoji Yasumizu
A 46-year-old woman who had received mastectomy for breast cancer 6 years earlier complained of abdominal distension. Computed tomography and ultrasonography revealed massive ascites and ovarian swelling of both sides. She was diagnosed as having primary ovarian cancer and peritoneal dissemination, and underwent a total hysterectomy as well as ovarectomy on both sides. After surgery, she received a sequential chemotherapy, ie, intraabdominal injection of carboplatin (CBDCA 300 mg/m2) and div administration of paclitaxel (PTX 180 mg/m2) as a standard regimen for advanced ovarian cancer...
March 2005: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Y Seki, M Imaizumi, K Shigemitsu, H Yoshioka, Y Ueda
The authors report are a rare case of primary mucinous adenocarcinoma of the anterior mediastinum in a 34-year-old Japanese woman. Routine chest radiography revealed an abnormal mass lesion in the left upper mediastinum. Her serum CA 19-9 level was elevated at 299 (normal < 37) U/ml. The large tumor in the anterior mediastinum, 8 cm in diameter, were made of multicystic part with thick wall and thick spetrum and solid part in chest computed tomography (CT). Teratoma was suggested by percutaneous needle biopsy under CT scanning...
May 2004: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Bart A J Jansen, Jaap Brouwer, Jan Reedijk
The sulfur-containing tripeptide glutathione (GSH) is one of the most abundant molecules in cells. Elevated levels of GSH render some types of cancer cells resistant against well-known platinum anti-cancer drugs such as cisplatin and carboplatin. Platinum complexes are often very reactive towards the cysteine residue of GSH, which detoxifies these compounds by a rapid binding mechanism. Clearly, this resistance mechanism poses a severe obstacle to any new platinum drugs designed to overcome cisplatin resistance...
April 28, 2002: Journal of Inorganic Biochemistry
M E L van der Burg, R de Wit, W L J van Putten, A Logmans, W H J Kruit, G Stoter, J Verweij
We investigated the potential of weekly cisplatin and daily oral etoposide followed by oral etoposide maintenance therapy in patients with platinum-refractory ovarium cancer. One hundred and seven patients were entered on the study, 98 patients completed the induction therapy consisting of cisplatin at either 50 or 70 mg m(-2) weekly for six administrations plus oral etoposide at a dose of 50 mg daily. Of these 98 patients, 38 had a platinum treatment-free interval of more than 12 months, 32 had an interval between 4 and 12 months, and 28 had progressed during or within 4 months after last platinum therapy...
January 7, 2002: British Journal of Cancer
O Kobayashi, K Konishi, M Kanari, H Cho, T Yoshikawa, A Tsuburaya, M Sairenji, H Motohashi
To evaluate the relationship between radical surgery of recurrent tumor and prognosis in cases of recurrent gastric cancer, we analyzed data on 202 patients with relapsed gastric cancer, focusing on surgical recurrent tumor removal. In our series, 18 of the 202 patients underwent radical recurrent tumor resection. Resected tumors were located in the ovarium (n = 4), colorectum (n = 3), liver (n = 3), lymph node (n = 2), locoregional stoma (n = 2), and peritoneum, adrenal gland, brain, and lung (n = 1 each)...
October 2001: Gan to Kagaku Ryoho. Cancer & Chemotherapy
J V Swinnen
Steroid hormones have a strong influence on the biology of several common human cancers, including cancer of the prostate, breast, endometrium and ovarium. To gain more insight into this process, a screening for androgen-regulated genes was set up in prostate cancer cells. In addition to their well known effects on cell survival, proliferation and differentiated function, androgens were found to markedly stimulate the expression of several lipogenic enzymes. In clinical cancer samples these enzymes are markedly overexpressed in comparison to normal tissues, allowing them to be used as cancer markers and as potential targets for antineoplastic therapy...
2001: Verhandelingen—Koninklijke Academie Voor Geneeskunde Van België
J J Hage, J J Dekker, R B Karim, R H Verheijen, E Bloemena
BACKGROUND: Ovarium cancer is the fifth most common cause of cancer-related death in women and is the most common fatal gynecologic malignancy. So far, ovarium carcinoma has not been reported to have occurred in female-to-male transsexuals. OBJECTIVE AND METHOD: We report on two such cases. Long-term exposure to increased levels of endogenous and exogenous androgens is hypothesized to constitute an additional risk factor in transsexuals as it has been associated with ovarian epithelian cancer...
March 2000: Gynecologic Oncology
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