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https://www.readbyqxmd.com/read/27909874/is-daily-low-dose-aspirin-safe-to-take-following-laparoscopic-roux-en-y-gastric-bypass-for-obesity-surgery
#1
Xian Kang, Dennis Hong, Mehran Anvari, Maria Tiboni, Nalin Amin, Scott Gmora
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery is a safe and effective procedure for patients with severe obesity. One potential complication of LRYGB is the development of marginal ulcers (MUs). Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to significantly increase the likelihood of developing marginal ulcers after surgery. However, the risk associated with low-dose aspirin consumption is not well defined. We examined the impact of daily low-dose aspirin (81 mg) on the development of marginal ulcers following LRYGB...
December 1, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27849643/comparison-of-rectal-indomethacin-diclofenac-and-naproxen-for-the-prevention-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#2
Amir H Mohammad Alizadeh, Mohammad Abbasinazari, Behzad Hatami, Saeed Abdi, Forozan Ahmadpour, Shideh Dabir, Aida Nematollahi, Samira Fatehi, Mohammad A Pourhoseingholi
BACKGROUND AND AIM: NSAIDs are commonly utilized for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). However, not much is known about the most effective drug in preventing this complication. This study aims to clarify which drug (indomethacin, diclofenac, or naproxen) is most effective for the prevention of post endoscopic retrograde cholangiopancreatography (ERCP). MATERIALS AND METHODS: In a double-blind, randomized study, patients received a single rectal dose of one of the three drugs 30 min before undergoing ERCP: diclofenac (100 mg), indomethacin (100 mg), or naproxen (500 mg)...
November 15, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27837343/effect-of-preoperative-oral-analgesics-on-pulpal-anesthesia-in-patients-with-irreversible-pulpitis-a-systematic-review-and-meta-analysis
#3
REVIEW
Armin Shirvani, Sayna Shamszadeh, Mohammad Jafar Eghbal, Laleh Alim Marvasti, Saeed Asgary
OBJECTIVES: The objectives of this study were to assess the efficacy of preemptive oral administration of single dose of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen on the local anesthetic success in adults with irreversible pulpitis and to find the possible covariates that could predict treatment effect. MATERIALS AND METHODS: A systematic search using electronic databases up to March 2015 was conducted. Odds ratio (OR) and 95% confidence intervals (CIs) were estimated using random and fixed-effect inverse variance method...
November 11, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27829810/effect-of-tramadol-on-metamizol-pharmacokinetics-and-pharmacodynamics-after-single-and-repeated-administrations-in-arthritic-rats
#4
Luis Alfonso Moreno-Rocha, Francisco Javier López-Muñoz, José Raúl Medina-López, Adriana Miriam Domínguez-Ramírez
Combined administration of certain doses of opioid compounds with a non-steroidal anti-inflammatory drug can produce additive or supra-additive effects while reducing unwanted effects. We have recently reported that co-administration of metamizol with tramadol produces antinociceptive effect potentiation, after acute treatment. However, none information about the effect produced by the combination after chronic or repeated dose administration exists. The aims of this study were to investigate whether the antinociceptive synergism produced by the combination of metamizol and tramadol (177...
November 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27822735/successful-treatment-of-chronic-recurrent-multifocal-osteomyelitis-using-low-dose-radiotherapy-a-case-report
#5
Christian T Dietzel, Christoph Schäfer, Dirk Vordermark
BACKGROUND: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disease, which lacks an infectious genesis and predominantly involves the metaphysis of long bones. Common treatments range from nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids at first onset of disease, to immunosuppressive drugs and bisphosphonates in cases of insufficient remission. The therapeutic use of low-dose radiotherapy for CRMO constitutes a novelty. CASE REPORT: A 67-year-old female patient presented with radiologically proven CRMO affecting the right tibia/talus and no response to immunosuppressive therapy...
November 7, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27813503/naproxen-paracetamol-and-pamabrom-versus-paracetamol-pyrilamine-and-pamabrom-in-primary-dysmenorrhea-a-randomized-double-blind-clinical-trial
#6
Mario I Ortiz, Gabriela Murguía-Cánovas, Laura C Vargas-López, Rodolfo Silva, Mario González-de la Parra
INTRODUCTION: Dysmenorrhea is caused by the discharge of prostaglandins into the uterine tissue; therefore, non-steroidal anti-inflammatory drugs (NSAIDs) are the established initial therapy for dysmenorrhea. Dysmenorrhea therapy may include the administration of drug monotherapy or combination therapy. However, clinical scientific evidence on the efficacy of medications with two or three drugs combined is scarce or nonexistent. OBJECTIVE: To evaluate and compare the efficacy and safety of two oral fixed-dose combinations for the relief of the symptoms of primary dysmenorrhea among Mexican women...
October 24, 2016: Medwave
https://www.readbyqxmd.com/read/27779311/detrimental-effect-of-systemic-antimicrobial-cd4-t-cell-reactivity-on-gut-epithelial-integrity
#7
Cheong K C Kwong Chung, Francesca Ronchi, Markus B Geuking
Healthy host-microbial mutualism relies on compartmentalization and proper regulation of systemic and mucosal immune responses. Nevertheless, the systemic immune system is frequently exposed to bouts of bacteraemia, which can trigger systemic antimicrobial immune reactivity including CD4(+) T cells. Low level bacteraemia can occur when immune compartmentalization is compromised, for example in the presence of innate immune deficiency or following use of nonsteroidal anti-inflammatory drugs (NSAID). We generated an Escherichia coli strain expressing a defined T helper neo-epitope to study systemic antigen-specific antimicrobial CD4(+) T cells and their potential involvement in the pathogenicity of inflammatory bowel diseases (IBD)...
October 24, 2016: Immunology
https://www.readbyqxmd.com/read/27767117/single-dose-oral-analgesics-for-postoperative-pain-have-few-adverse-events
#8
Yin J Wong
Data sourcesThe Cochrane Database of Systematic Reviews on the Cochrane Library.Study selectionAll Cochrane reviews of RCTs between 1999 to 2015, conducted in adults examining the adverse events associated with single dose oral analgesics used for acute post-operative pain were considered.Data extraction and synthesisStudies were searched, reviewed and assessed independently by two reviewers and standard data items extracted. Methodological quality was assessed using criteria adapted from AMSTAR (Assessing the Methodological Quality of Systematic Reviews)...
September 2016: Evidence-based Dentistry
https://www.readbyqxmd.com/read/27758759/nasal-ketorolac-challenge-using-an-acoustic-rhinomether-in-patients-with-aspirin-exacerbated-respiratory-disease
#9
J Quiralte-Castillo, M Del Robledo Ávila-Castellano, S Cimbollek, P Benaixa, S Leguisamo, K Baynova, M Labella, J Quiralte
BACKGROUND: Safer and less time consuming alternatives to single-blind placebo-controlled oral challenge (SBPCOC) in order to diagnose aspirin-exacerbated respiratory disease (AERD) have been searched for. Nasal challenges with different non-steroidal anti-inflammatory drugs and assessment methods have been developed. OBJECTIVE: Our objective was to evaluate the utility and safety of nasal ketorolac challenge (NKC) using an acoustic rhinomether in patients with suspected AERD Methods: Thirty-six patients with suspected AERD were included in the study...
October 19, 2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27743405/non-steroidal-anti-inflammatory-drugs-for-sciatica
#10
REVIEW
Eva Rasmussen-Barr, Ulrike Held, Wilhelmus Ja Grooten, Pepijn Ddm Roelofs, Bart W Koes, Maurits W van Tulder, Maria M Wertli
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed drugs for the treatment of sciatica. A previous Cochrane review on the efficacy of NSAIDs summarised findings for acute and chronic low back pain (LBP) and sciatica. This is an update of the original review (2008) focusing on people suffering from sciatica. OBJECTIVES: To determine the efficacy of NSAIDs in pain reduction, overall improvement, and reported side effects in people with sciatica...
October 15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27706879/acute-kidney-injury-post-major-orthopaedic-surgery-a-single-centre-case-control-study
#11
Tracey Ying, Samantha Chan, Stephen Lane, Christine Somerville
AIM: To identify risk factors for acute kidney injury following major orthopaedic surgery. METHODS: We included all patients undergoing major orthopaedic surgery at University Hospital Geelong between 2008 and 2014 in the study. Out of 2188 surgeries audited, we identified cases of acute kidney injury using the RIFLE criteria and matched those to controls 2:1 for age, sex, procedure and chronic kidney disease stage. We reviewed their records for risk factors of postoperative acute kidney injury, including medications such as gentamicin, diuretics, non-steroidal anti-inflammatory drugs and angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use...
October 5, 2016: Nephrology
https://www.readbyqxmd.com/read/27621519/effect-of-karamard%C3%A4-di-yoga-versus-diclofenac-sodium-in-post-operative-pain-management-a-randomized-comparative-clinical-trial
#12
Rahul Hegana, Hemant Devaraj Toshikhane, Sangeeta Toshikhane, Hetal Amin
INTRODUCTION: Post-operative pain is Nociceptive i.e., anticipated unavoidable physiological pain which is caused due to tissue trauma. Drugs such as NSAIDs (Non Steroidal Anti Inflammatory Drugs) and Opioids are used for post-operative pain management but are associated with their own drawbacks. Karamardādi Yoga has been in use in Ayurvedic practice for analgesia. It is known to relieve pain and can be used to supplement anaesthesia and also get rid of adverse effect of modern analgesic drugs...
April 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/27581248/pharmacokinetic-drug-drug-interactions-between-vonoprazan-and-low-dose-aspirin-or-nonsteroidal-anti-inflammatory-drugs-a-phase-2-open-label-study-in-healthy-japanese-men
#13
Yuuichi Sakurai, Madoka Shiino, Sayako Horii, Hiroyuki Okamoto, Koki Nakamura, Akira Nishimura, Yukikuni Sakata
BACKGROUND: Gastroprotective agents are recommended for patients receiving low-dose aspirin (LDA) or nonsteroidal anti-inflammatory drugs (NSAIDs). Vonoprazan is a potassium-competitive acid blocker recently approved for the prevention of peptic ulcer recurrence in patients receiving LDA or NSAIDs. METHODS: This phase 2, open-label, single-center study in healthy Japanese males evaluated drug-drug interactions between vonoprazan 40 mg and LDA (100 mg) or NSAIDs [loxoprofen sodium (60 mg), diclofenac sodium (25 mg), or meloxicam (10 mg)] and vice versa...
August 31, 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27473088/measuring-transaminases-in-patients-with-rheumatoid-arthritis-on-weekly-methotrexate-does-timing-of-blood-testing-matter
#14
Christopher A Mecoli, Nikolay G Delev, Clifton O Bingham
The change in transaminase levels over a single week during therapy with methotrexate (MTX) has not been investigated or reported to date. In clinical practice, it is common to observe abnormal transaminase levels upon routine blood work for toxicity monitoring. Many have suggested that such lab abnormalities can sometimes be attributed to sampling blood for toxicity monitoring proximately following MTX dosing. The aim of our study was to evaluate changes in transaminase levels (AST/ALT) over 1 week after MTX administration in rheumatoid arthritis (RA) patients...
December 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27468823/lornoxicam-injection-is-inferior-to-betamethasone-in-the-treatment-of-subacromial-impingement-syndrome-a-prospective-randomized-study-of-functional-outcomes
#15
M Aksakal, C Ermutlu, G Özkaya, Y Özkan
BACKGROUND: Subacromial impingement syndrome (SIS) is one of the most frequent shoulder pathologies. Initial treatment is conservative. Subacromial injection of drugs achieves a high concentration at the pathologic site with less drug use and fewer systemic side effects. Glucocorticoids are most frequently injected. One concern with steroid use is the wide array of potential systemic and local complications. Nonsteroidal anti-inflammatory drugs (NSAIDs) are also peripherally acting and can be used locally...
July 28, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27412362/oral-non-steroidal-anti-inflammatory-drugs-single-dose-for-perineal-pain-in-the-early-postpartum-period
#16
REVIEW
Francesca Wuytack, Valerie Smith, Brian J Cleary
BACKGROUND: Many women experience perineal pain after childbirth, especially after having sustained perineal trauma. Perineal pain-management strategies are thus an important part of postnatal care. Non-steroidal anti-inflammatory drugs (NSAIDs) are a commonly used type of medication in the management of postpartum pain and their effectiveness and safety should be assessed. OBJECTIVES: To determine the effectiveness of a single dose of an oral NSAID for relief of acute perineal pain in the early postpartum period...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27372601/h1-antihistamine-premedication-in-nsaid-associated-urticaria
#17
Axel Trautmann, Diana Anders, Johanna Stoevesandt
BACKGROUND: Therapeutic options for pain management are restricted in patients with nonsteroidal anti-inflammatory drug (NSAID)-induced or NSAID-exacerbated urticaria because strong cyclooxygenase (COX)-I inhibiting NSAID cannot be used. Alternative NSAID such as weak COX-I inhibitors or selective COX-II inhibitors are sometimes not sufficiently effective or have potentially troublesome adverse effects. OBJECTIVE: To date, prophylactic premedication with H1-antihistamines is rarely practiced in patients concurrently suffering from recurrent pain and NSAID-associated urticaria...
June 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27223141/effective-method-for-the-detection-of-piroxicam-in-human-plasma-using-hplc
#18
Adriana Maria Calvo, Mariel Tavares de Oliveira Prado, Thiago José Dionísio, Maria Paula Marques, Daniel Thomas Brozoski, Vera Lúcia Lanchote, Flávio Augusto Cardoso Faria, Carlos Ferreira Santos
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used by the general population to alleviate inflammation and pain after oral surgeries. Piroxicam is among the most commonly used NSAIDs and excels in controlling pain, swelling, trismus and other common symptoms of inflammation. This study aimed to evaluate different concentrations of piroxicam and its major metabolite, 5'-hydroxypiroxicam, in human plasma samples over time using high performance liquid chromatography (HPLC) after liquid-liquid extraction...
May 20, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27140500/single-dose-intra-articular-morphine-for-pain-control-after-knee-arthroscopy
#19
REVIEW
Zui Zou, Mao Mao An, Qun Xie, Xiao Y Chen, Hao Zhang, Guan J Liu, Xue Y Shi
BACKGROUND: Knee arthroscopy is a common procedure and is associated with postoperative pain. Intra-articular (IA) injection of morphine for pain control has been widely studied, but its analgesic effect after knee arthroscopy is uncertain. OBJECTIVES: To evaluate the relative effects on pain relief and adverse events of IA morphine given for pain control after knee arthroscopy compared with placebo, other analgesics (local anaesthetics, non-steroidal anti-inflammatory drugs (NSAIDs), other opioids) and other routes of morphine administration...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27129120/piroxicam-immediate-release-formulations-a-fasting-randomized-open-label-crossover-bioequivalence-study-in-healthy-volunteers
#20
Sally A Helmy, Heba M El-Bedaiwy
Piroxicam is a NSAID with analgesic and antipyretic properties, used for the treatment of rheumatoid diseases. The aim of this study was to evaluate the bioequivalence of two brands of piroxicam capsules (20 mg) in 24 Egyptian volunteers. The in vivo study was established according to a single-center, randomized, single-dose, laboratory-blinded, 2-period, 2-sequence, crossover study with a washout period of 3 weeks. Under fasting conditions, 24 healthy male volunteers were randomly selected to receive a single oral dose of one capsule (20 mg) of either test or reference product...
November 2014: Clinical Pharmacology in Drug Development
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