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https://www.readbyqxmd.com/read/28416614/modeling-combined-immunosuppressive-and-anti-inflammatory-effects-of-dexamethasone-and-naproxen-in-rats-predicts-the-steroid-sparing-potential-of-naproxen
#1
Xiaonan Li, Debra C DuBois, Dawei Song, Richard R Almon, William J Jusko, Xijing Chen
Dexamethasone (DEX), a widely prescribed corticosteroid (CS), has long been the cornerstone for the treatment of inflammation and immunological dysfunctions in Rheumatoid Arthritis (RA). The CS are frequently used in combination with other anti-rheumatic agents such as nonsteroidal anti-inflammatory drugs (NSAIDs) and disease-modifying anti-rheumatic drugs (DMARDs) to mitigate disease symptoms and minimize unwanted effects. The steroid dose-sparing potential of the NSAID naproxen (NPX) was explored with in vitro and in vivo studies...
April 17, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28386870/two-release-rates-from-monolithic-carboxymethyl-starch-tablets-formulation-characterization-and-in-vitro-in-vivo-evaluation
#2
Tien Canh Le, Mircea Alexandru Mateescu
Most of non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen at more than 1200 mg/day may generate gastrointestinal and cardiovascular side effects. Bilayer or multiparticulate devices have been developed for controlled release in order to prevent undesired side effects. A new "two release rate (2RR) monolithic tablets" approach is now proposed for controlled release of poorly soluble drugs, particularly NSAIDs. Ibuprofen was used as model drug. This concept is based on a calcium carboxymethyl-starch (CaCMS) complex as a novel, low-cost excipient for monolithic dosage forms easy to manufacture by direct compaction...
April 6, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28337899/substance-p-expression-in-the-gingival-tissue-after-upper-third-molar-extraction-effect-of-ketoprofen-a-preliminary-study
#3
G M Abbate, A Mangano, P Sacerdote, G Amodeo, G Moschetti, L Levrini
The aim of this study was to evaluate substance P (SP) levels and the effect of a non-steroidal anti-inflammatory drug (NSAID), ketoprofen, on SP in the pericoronal gingival tissue after extraction of upper third molars. A sample of 20 young non-smoking systemically healthy adults of both sexes, with a healthy upper third molar to extract for orthodontic purposes, was selected. After extraction, a sample of the gingival tissue of the pericoronal region was collected with a sterile scalpel, placed into test tubes and kept frozen at -20°C until the SP determination...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28283838/the-effect-of-nsaids-on-spinal-fusion-a-cross-disciplinary-review-of-biochemical-animal-and-human-studies
#4
REVIEW
Ahilan Sivaganesan, Silky Chotai, Gabrielle White-Dzuro, Matthew J McGirt, Clinton J Devin
PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in postoperative pain management. However, their use in the setting of spine fusion surgery setting has long been a topic of controversy. In this review we examined relevant research, including in vivo, animal, and clinical human studies, with the aim of understanding the effect of NSAIDs on spinal fusion. STUDY DESIGN/SETTING: Systematic review of study designs of all types from randomized controlled trials and meta-analyses to single-institution retrospective reviews...
March 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28246618/effect-of-intravenous-ketorolac-on-postoperative-pain-in-mandibular-fracture-surgery-a-randomized-double-blind-placebo-controlled-trial
#5
Hamid Reza Eftekharian, Homa Ilkhani Pak
OBJECTIVE: To evaluate the effects of intravenous ketorolac on early postoperative pain in patients with mandibular fractures, who underwent surgical repair. METHODS: This prospective, randomized, placebo-controlled clinical trial was conducted in Shahid Rajaei Hospital, affiliated with Shiraz University of Medical Sciences during a 1-year period from 2015 to 2016. We included a total number of 50 patients with traumatic mandibular fractures who underwent surgical repair...
January 2017: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/28246127/modeling-sex-differences-in-pharmacokinetics-pharmacodynamics-and-disease-progression-effects-of-naproxen-in-rats-with-collagen-induced-arthritis
#6
Xiaonan Li, Debra C DuBois, Richard R Almon, William J Jusko
Naproxen (NPX) is a frequently used nonsteroidal anti-inflammatory drug (NSAID) for rheumatoid arthritis (RA). Lack of quantitative information about the drug exposure-response relationship has resulted in empirical dosage regimens for use of NPX in RA. Few studies included sex as a factor, although RA predominates in women. A pharmacokinetic, pharmacodynamic, and disease progression (PK/PD/DIS) model described the anti-inflammatory effects of NPX in collagen-induced arthritic (CIA) male and female rats. Three groups of rats were included for each sex: healthy animals, CIA controls, and CIA rats given 50 mg/kg single dose NPX intraperitoneally (IP)...
February 28, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28245728/risk-factors-for-acute-kidney-injury-associated-with-the-treatment-of-bacterial-endocarditis-at-a-tertiary-academic-medical-center
#7
Brianne M Ritchie, Beth A Hirning, Craig A Stevens, Steven A Cohen, Jeremy R DeGrado
BACKGROUND: Acute kidney injury (AKI) is a common complication of endocarditis. OBJECTIVE: To determine risk factors for the development of AKI in patients treated for endocarditis. METHODS: This single centre, retrospective univariate and multivariate analysis to determine risk factors for the development of AKI included patients diagnosed with endocarditis between January 2009 and October 2013. RESULTS: Of 211 included patients, a total of 84 (39...
March 1, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28178590/the-pharmacokinetics-of-oral-ketoprofen-in-patients-after-gastric-resection
#8
Joanna Porażka, Agnieszka Karbownik, Dawid Murawa, Arkadiusz Spychała, Magdalena Firlej, Tomasz Grabowski, Paweł Murawa, Edmund Grześkowiak, Edyta Szałek
BACKGROUND: Total and partial gastric resection may affect the pharmacokinetics of drugs, especially orally administered a few days after surgery. Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) broadly used to treat postoperative pain, including patients after gastric resection. The aim of the research was to analyse the pharmacokinetics (PK) of orally administered ketoprofen in patients after gastrectomy. METHODS: The research was carried out on two groups of patients after total (TG; Roux-Y procedure) and partial (PG; Billroth II procedure) gastrectomy...
April 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28145788/preclinical-and-pharmacotoxicology-evaluation-of-%C3%AE-l-guluronic-acid-g2013-as-a-non-steroidal-anti-inflammatory-drug-with-immunomodulatory-property
#9
Sepideh Nazeri, Shahin Khadem Azarian, Mohammad Javad Fattahi, Reza Sedaghat, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Mohammad Abdollahi, Abbas Mirshafiey
CONTEXT: Therapeutic effects of α-l-guluronic acid with the greatest tolerability and efficacy (G2013) have been shown in experimental model of multiple sclerosis and other in vitro and in vivo examinations regarding α-l-guluronic acid; there are no toxicological researches on its safety although the pharmacological impacts have been recorded. OBJECTIVE: This study was designed to determine the acute and sub chronic toxicity of α-l-guluronic acid in healthy male and female BALB/c mice...
April 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28123620/patterns-of-ketorolac-dosing-by-emergency-physicians
#10
Emil Soleyman-Zomalan, Sergey Motov, Antonios Likourezos, Victor Cohen, Illya Pushkar, Christian Fromm
BACKGROUND: Ketorolac tromethamine is a non-steroidal anti-inflammatory drug (NSAIDs) that is widely used in the emergency department (ED) for the treatment of moderate-to-severe pain. Ketorolac, like other NSAIDs, exhibits an analgesic ceiling effect and previous research suggests that 10 mg is possibly the ceiling dose. Do the patterns of ketorolac dosing by emergency physicians follow its analgesic ceiling dose? METHODS: This was a single center retrospective, descriptive study to characterize patterns of ketorolac administration in ED patients...
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28025372/a-pooled-analysis-evaluating-renal-safety-in-placebo-and-active-comparator-controlled-phase-iii-trials-of-multiple-dose-injectable-hp%C3%AE-cd-diclofenac-in-subjects-with-acute-postoperative-pain
#11
Stephen E Daniels, Tong J Tj Gan, Douglas A Hamilton, Neil Singla, Peter G Lacouture, Olufunmibi Johnson, Lauren H Min, Christian R D Reyes, Daniel B Carr
OBJECTIVE : While injectable nonsteroidal anti-inflammatory drugs (NSAIDs) are a key component of postoperative multimodal analgesia, renal safety concerns may limit use in some patients. This study examined the renal safety of injectable HPβCD-diclofenac when given for ≤ 5 days following orthopedic or abdominal/pelvic surgery. METHODS : Pooled analysis of data from two randomized, placebo- and active comparator-controlled phase III trials in 608 total patients was conducted. Renal safety was assessed by examining treatment-emergent adverse events (AEs) and postoperative blood urea nitrogen (BUN) and serum creatinine shifts...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27981527/examination-of-the-pharmacodynamics-and-pharmacokinetics-of-a-diclofenac-poly-lactic-co-glycolic-acid-nanoparticle-formulation-in-the-rat
#12
S Harirforoosh, K O West, D E Murrell, J W Denham, P C Panus, G A Hanley
OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are assembled into two categories; cyclooxygenase (COX-1) sparing inhibitors of COX-2 and non-selective NSAIDs. Diclofenac (DICLO) is a non-selective NSAID that has been linked to serious side effects including gastric ulcers and renal injury. In this study, we examine the effect of poly(lactic-co-glycolic) acid nanoformulation on DICLO-associated adverse events and pharmacokinetics using a nanoparticle (NP) formulation previously developed in our laboratory...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27909874/is-daily-low-dose-aspirin-safe-to-take-following-laparoscopic-roux-en-y-gastric-bypass-for-obesity-surgery
#13
Xian Kang, Dennis Hong, Mehran Anvari, Maria Tiboni, Nalin Amin, Scott Gmora
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery is a safe and effective procedure for patients with severe obesity. One potential complication of LRYGB is the development of marginal ulcers (MUs). Nonsteroidal anti-inflammatory drugs (NSAIDs) are known to significantly increase the likelihood of developing marginal ulcers after surgery. However, the risk associated with low-dose aspirin consumption is not well defined. We examined the impact of daily low-dose aspirin (81 mg) on the development of marginal ulcers following LRYGB...
May 2017: Obesity Surgery
https://www.readbyqxmd.com/read/27849643/comparison-of-rectal-indomethacin-diclofenac-and-naproxen-for-the-prevention-of-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis
#14
Amir H Mohammad Alizadeh, Mohammad Abbasinazari, Behzad Hatami, Saeed Abdi, Forozan Ahmadpour, Shideh Dabir, Aida Nematollahi, Samira Fatehi, Mohammad A Pourhoseingholi
BACKGROUND AND AIM: NSAIDs are commonly utilized for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). However, not much is known about the most effective drug in preventing this complication. This study aims to clarify which drug (indomethacin, diclofenac, or naproxen) is most effective for the prevention of post endoscopic retrograde cholangiopancreatography (ERCP). MATERIALS AND METHODS: In a double-blind, randomized study, patients received a single rectal dose of one of the three drugs 30 min before undergoing ERCP: diclofenac (100 mg), indomethacin (100 mg), or naproxen (500 mg)...
March 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27837343/effect-of-preoperative-oral-analgesics-on-pulpal-anesthesia-in-patients-with-irreversible-pulpitis-a-systematic-review-and-meta-analysis
#15
REVIEW
Armin Shirvani, Sayna Shamszadeh, Mohammad Jafar Eghbal, Laleh Alim Marvasti, Saeed Asgary
OBJECTIVES: The objectives of this study were to assess the efficacy of preemptive oral administration of single dose of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen on the local anesthetic success in adults with irreversible pulpitis and to find the possible covariates that could predict treatment effect. MATERIALS AND METHODS: A systematic search using electronic databases up to March 2015 was conducted. Odds ratio (OR) and 95% confidence intervals (CIs) were estimated using random and fixed-effect inverse variance method...
January 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27829810/effect-of-tramadol-on-metamizol-pharmacokinetics-and-pharmacodynamics-after-single-and-repeated-administrations-in-arthritic-rats
#16
Luis Alfonso Moreno-Rocha, Francisco Javier López-Muñoz, José Raúl Medina-López, Adriana Miriam Domínguez-Ramírez
Combined administration of certain doses of opioid compounds with a non-steroidal anti-inflammatory drug can produce additive or supra-additive effects while reducing unwanted effects. We have recently reported that co-administration of metamizol with tramadol produces antinociceptive effect potentiation, after acute treatment. However, none information about the effect produced by the combination after chronic or repeated dose administration exists. The aims of this study were to investigate whether the antinociceptive synergism produced by the combination of metamizol and tramadol (177...
November 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27822735/successful-treatment-of-chronic-recurrent-multifocal-osteomyelitis-using-low-dose-radiotherapy-a-case-report
#17
Christian T Dietzel, Christoph Schäfer, Dirk Vordermark
BACKGROUND: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disease, which lacks an infectious genesis and predominantly involves the metaphysis of long bones. Common treatments range from nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids at first onset of disease, to immunosuppressive drugs and bisphosphonates in cases of insufficient remission. The therapeutic use of low-dose radiotherapy for CRMO constitutes a novelty. CASE REPORT: A 67-year-old female patient presented with radiologically proven CRMO affecting the right tibia/talus and no response to immunosuppressive therapy...
March 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27813503/naproxen-paracetamol-and-pamabrom-versus-paracetamol-pyrilamine-and-pamabrom-in-primary-dysmenorrhea-a-randomized-double-blind-clinical-trial
#18
Mario I Ortiz, Gabriela Murguía-Cánovas, Laura C Vargas-López, Rodolfo Silva, Mario González-de la Parra
INTRODUCTION: Dysmenorrhea is caused by the discharge of prostaglandins into the uterine tissue; therefore, non-steroidal anti-inflammatory drugs (NSAIDs) are the established initial therapy for dysmenorrhea. Dysmenorrhea therapy may include the administration of drug monotherapy or combination therapy. However, clinical scientific evidence on the efficacy of medications with two or three drugs combined is scarce or nonexistent. OBJECTIVE: To evaluate and compare the efficacy and safety of two oral fixed-dose combinations for the relief of the symptoms of primary dysmenorrhea among Mexican women...
October 24, 2016: Medwave
https://www.readbyqxmd.com/read/27779311/detrimental-effect-of-systemic-antimicrobial-cd4-t-cell-reactivity-on-gut-epithelial-integrity
#19
Cheong K C Kwong Chung, Francesca Ronchi, Markus B Geuking
Healthy host-microbe mutualism relies on compartmentalization and proper regulation of systemic and mucosal immune responses. Nevertheless, the systemic immune system is frequently exposed to bouts of bacteraemia, which can trigger systemic antimicrobial immune reactivity including CD4(+) T cells. Low-level bacteraemia can occur when immune compartmentalization is compromised, for example in the presence of innate immune deficiency or following use of non-steroidal anti-inflammatory drugs. We generated an Escherichia coli strain expressing a defined T helper neo-epitope to study systemic antigen-specific antimicrobial CD4(+) T cells and their potential involvement in the pathogenisis of inflammatory bowel diseases...
February 2017: Immunology
https://www.readbyqxmd.com/read/27767117/single-dose-oral-analgesics-for-postoperative-pain-have-few-adverse-events
#20
COMMENT
Yin J Wong
Data sourcesThe Cochrane Database of Systematic Reviews on the Cochrane Library.Study selectionAll Cochrane reviews of RCTs between 1999 to 2015, conducted in adults examining the adverse events associated with single dose oral analgesics used for acute post-operative pain were considered.Data extraction and synthesisStudies were searched, reviewed and assessed independently by two reviewers and standard data items extracted. Methodological quality was assessed using criteria adapted from AMSTAR (Assessing the Methodological Quality of Systematic Reviews)...
2016: Evidence-based Dentistry
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