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JOURNAL ARTICLE
Ahmad S Kodous, Mostafa A Abdel-Maksoud, Mohamed A El-Tayeb, Diana A Al-Sherif, Suzan Shawky Abuelkasem Mohamed, Mohamed Mohamady Ghobashy, Ayat M Emad, Shady M Abd El-Halim, Soheir A A Hagras, Samson Mani, Arunagiri Kuha Deva Magendhra Rao, Ahmed M Hussein, Helen N Saada
INTRODUCTION: Skin injuries represent a prevalent form of physical trauma, necessitating effective therapeutic strategies to expedite the wound healing process. Hesperidin, a bioflavonoid naturally occurring in citrus fruits, exhibits a range of pharmacological attributes, including antimicrobial, antioxidant, anti-inflammatory, anticoagulant, and analgesic properties. The main objective of the study was to formulate a hydrogel with the intention of addressing skin conditions, particularly wound healing...
2024: Frontiers in Immunology
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JOURNAL ARTICLE
Amir Kabunga, Eustes Kigongo, Ponsiano Okalo, Samson Udho, Anna Auma Grace, Raymond Tumwesigye, Anne Ruth Akello, Marvin Musinguzi, Walter Acup, Jannat Nabaziwa, Enos Mwirotsi Shikanga, Haliama Namata
BACKGROUND: The escalating global prevalence of burnout among healthcare professionals poses a serious health concern. Recent studies focus on prevalence and predictors of burnout among healthcare providers, emphasizing the need for well-being interventions. This study investigates burnout and coping mechanisms among healthcare professionals in central Uganda, addressing the dearth of knowledge about coping strategies specific to the region. METHODS: An analytical facility cross-sectional study was conducted in five healthcare facilities in central Uganda between June to July 2023...
2024: Frontiers in Psychiatry
#23
JOURNAL ARTICLE
Patrick Budylowski, Serena L L Chau, Arinjay Banerjee, Furkan Guvenc, Reuben Samson, Queenie Hu, Lindsey Fiddes, Laurie Seifried, Gary Chao, Megan Buchholz, Antonio Estacio, Patti Lou Cheatley, Katerina Pavenski, Christopher J Patriquin, Yanling Liu, Salma Sheikh-Mohamed, Kimberly Crasta, FengYun Yue, Maria D Pasic, Karen Mossman, Anne-Claude Gingras, Jennifer L Gommerman, Götz R A Ehrhardt, Samira Mubareka, Mario Ostrowski
Although high titers of neutralizing Abs in human serum are associated with protection from reinfection by SARS-CoV-2, there is considerable heterogeneity in human serum-neutralizing Abs against SARS-CoV-2 during convalescence between individuals. Standard human serum live virus neutralization assays require inactivation of serum/plasma prior to testing. In this study, we report that the SARS-CoV-2 neutralization titers of human convalescent sera were relatively consistent across all disease states except for severe COVID-19, which yielded significantly higher neutralization titers...
April 29, 2024: Journal of Immunology
#24
REVIEW
Brett Doleman, Siv Fonnes, Jon N Lund, Hannah Boyd-Carson, Hannah Javanmard-Emamghissi, Susan Moug, Marianne Hollyman, Gillian Tierney, Samson Tou, John P Williams
BACKGROUND: Acute appendicitis is one of the most common emergency general surgical conditions worldwide. Uncomplicated/simple appendicitis can be treated with appendectomy or antibiotics. Some studies have suggested possible benefits with antibiotics with reduced complications, length of hospital stay, and the number of days off work. However, surgery may improve success of treatment as antibiotic treatment is associated with recurrence and future need for surgery. OBJECTIVES: To assess the effects of antibiotic treatment for uncomplicated/simple acute appendicitis compared with appendectomy for resolution of symptoms and complications...
April 29, 2024: Cochrane Database of Systematic Reviews
#25
REVIEW
Rita Oppong, David Yeboah, Mohammed Owusu-Ansah, Samson Pandam Salifu
PURPOSE: Although radiation therapy is an effective treatment for breast cancer, it has a low rate of use in African countries. A systematic review was undertaken to investigate studies that used radiation therapy as a treatment modality for patients with breast cancer in Africa, focusing on survival outcomes, adverse effects, radiation therapy techniques, fractionation schedules, and effectiveness of radiation therapy. METHODS AND MATERIALS: We conducted a comprehensive literature search for studies that treated breast cancer with radiation therapy, using different electronic databases (PubMed, Scopus, and EBSCOhost) up to February 2023...
June 2024: Advances in Radiation Oncology
#26
JOURNAL ARTICLE
Ibrahim O Sawaid, Abraham O Samson, Rowa Al-Ramahi
Background: Colorectal cancer (CRC) is the second most widespread cancer among Palestinian patients. As cancer care improves in hospitals across the West Bank, services like palliative care, targeted therapy, bone marrow transplantation, and individualized therapy are still limited. This study aimed to assess the CRC stages, treatment protocols, and survival rates of patients in the West Bank. Methodology: This retrospective study collected data from the medical records of Al-Najah University Hospital (NUH), which specializes in the care of cancer patients...
April 15, 2024: Journal of Clinical Medicine
#27
JOURNAL ARTICLE
Gloria O Izu, Emmanuel Mfotie Njoya, Gaetan T Tabakam, Jennifer Nambooze, Kgalaletso P Otukile, Seiso E Tsoeu, Victoria O Fasiku, Ayodeji M Adegoke, Ochuko L Erukainure, Samson S Mashele, Tshepiso J Makhafola, Mamello P Sekhoacha, Chika I Chukwuma
Oxidative stress is pivotal in the pathology of many diseases. This study investigated the antioxidant phytochemistry of avocado ( Persea americana Mill.) peel. Different solvent extracts (dichloromethane, ethyl acetate, methanol, and water) of avocado peel were subjected to total phenol and flavonoid quantification, as well as in vitro radical scavenging and ferric reducing evaluation. The methanol extract was subjected to gradient column chromatographic fractionation. Fraction 8 (eluted with hexane:chloroform:methanol volume ratio of 3:6...
April 12, 2024: Antioxidants (Basel, Switzerland)
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JOURNAL ARTICLE
Emmanuel Mfotie Njoya, Gaetan T Tabakam, Chika I Chukwuma, Samson S Mashele, Tshepiso J Makhafola
According to a survey, the medicinal use of Androstachys johnsonii Prain is kept secret by traditional healers. Considering that inflammation and oxidative stress are major risk factors for the progression of various chronic diseases and disorders, we resolved to investigate the antioxidant and anti-inflammatory potentials of A. johnsonii using in vitro and cell-based assays. The antioxidant activity of A. johnsonii hydroethanolic leaf extract (AJHLE) was evaluated using the ABTS, DPPH, and FRAP assays. Its cytotoxic effect was assessed on RAW 264...
March 27, 2024: Antioxidants (Basel, Switzerland)
#29
JOURNAL ARTICLE
Luna Kamau, Kelly L Bennett, Eric Ochomo, Jeremy Herren, Silas Agumba, Samson Otieno, Diana Omoke, Damaris Matoke-Muhia, David Mburu, Joseph Mwangangi, Edith Ramaita, Elijah O Juma, Charles Mbogo, Sonia Barasa, Alistair Miles
BACKGROUND: Anopheles coluzzii is a primary vector of malaria found in West and Central Africa, but its presence has hitherto never been documented in Kenya. A thorough understanding of vector bionomics is important as it enables the implementation of targeted and effective vector control interventions. Malaria vector surveillance efforts in the country have tended to focus on historically known primary vectors. The current study sought to determine the taxonomic status of samples collected from five different malaria epidemiological zones in Kenya as well as describe the population genetic structure and insecticide resistance profiles in relation to other An...
April 26, 2024: Malaria Journal
#30
JOURNAL ARTICLE
Iniobong Chukwuebuka Ugochukwu, Iasmina Luca, Amienwanlen Eugene Odigie, Emmanuel Okechukwu Njoga, Nuhu Abdulazeez Sani, James Samson Enam, Wafa Rhimi, Sa'idu Tanko Muhammad, Abdussamad Abubakar, Aliyu Mohammed Wakawa, Patricia Otuh, Taiwo Adebiyi, Onyeka Chidiebere Nwufoh, Ikechukwu Udeani, Tosin Oyeleye, Theophilus Aghogho Jarikre, Sheriff Yusuf Idris, Abdulaziz Bada, Zaid Shehu, Ajadi Tola, Chidi Okonkwo, Chioma Frances Egwuogu, Uchechukwu Nnanna Njoku, Ohiemi Benjamin Ocheja, Joel Dzongor, Barka Grema, Najume Dogowar G Ibrahim, Celestine O I Njoku, Anthony Kojo B Sackey, Benjamin O Emikpe, Adamu Yunusa, John Ikechukwu Ihedioha, Balarabe Magaji Jahun, Sunday O Udegbunam, Shodeinde Vincent O Shoyinka
Incidence data from 17-year veterinary neoplasm surveillance and registration were reviewed. Most of the neoplastic cases diagnosed in Nigerian veterinary teaching hospitals (VTHs) were in the avian (49%) and canine species (44%). Fewer cases were recorded in the equine (3.2%), bovine (2.4%), ovine (1.5%), caprine (0.3%) and porcine (0.15%) species. Marek's disease was the most prevalently diagnosed neoplastic disease of domestic animals in Nigerian VTHs from 2000-2017. Also, the Nigerian local breed had a higher mean distribution than any other dog breed and this was statistically significant ( p < 0...
April 13, 2024: Veterinary Sciences
#31
JOURNAL ARTICLE
Thomas Döring, Kevin Weiland, Carolin Plattner, Tobias Huber, Dirk Bächle, Daniel Samson
The loading (i.e., substitution) of solid supports for oligonucleotide synthesis is an important parameter in large-scale manufacturing of oligonucleotides. Several key process parameters are dependent on the substitution of the solid support, including the number of phosphoramidite nucleoside equivalents used in the coupling step. For dimethoxytrityl (DMTr)-loaded solid supports, the substitution of the resin is determined by quantitatively cleaving the DMTr protecting group from the resin under acidic conditions and then analyzing the DMTr cation extinction by UV/vis spectroscopy...
April 2024: Current protocols
#32
JOURNAL ARTICLE
Eustes Kigongo, Raymond Tumwesigye, Maxson Kenneth Anyolitho, Marvin Musinguzi, Gad Kwizera, Everlyne Achan, Caroline Kambugu Nabasirye, Samson Udho, Amir Kabunga, Bernard Omech
BACKGROUND: Access to family planning services among young people is crucial for reproductive health. This study explores the access and associated factors among young people in Lira City, Northern Uganda. METHODS AND MATERIALS: A mixed-methods study was conducted in March to April 2022. Quantitative data were collected using a structured questionnaire from 553 participants aged 15-24 years. Qualitative data were obtained through in-depth interviews and focus group discussions...
April 24, 2024: BMC Public Health
#33
JOURNAL ARTICLE
Patrick A Twohig, Thoetchai Bee Peeraphatdit, Kaeli Samson, Makayla Schissel, Lynette Smith, Allison Ashford, Laura Freese, Timothy McCashland
BACKGROUND: Over 50% of hospitalizations from hepatic encephalopathy (HE) are preventable, but patients often do not receive medical treatment. AIMS: To use a multimodal education intervention (MMEI) to increase HE treatment rates and to evaluate (1) trends in HE treatment, (2) predictors of receiving treatment, and (3) the impact of treatment on hospitalization outcomes. METHODS: Prospective single-center cohort study of patients hospitalized with HE from April 1, 2020-September 30, 2022...
April 23, 2024: Digestive Diseases and Sciences
#34
REVIEW
Cody J Malone, Antti Oksanen, Samson Mukaratirwa, Rajnish Sharma, Emily Jenkins
Zoonotic nematodes of the genus Trichinella are foodborne parasites that have a global distribution in wild carnivores and omnivores, with spillover and spillback into domestic livestock and people, with concomitant trade and health consequences. Historically, most human cases were linked to domestic pigs infected with Trichinella spiralis, but under current high biosecurity swine production in many countries, wildlife have become a more important source of human trichinellosis. The aim of this review is to update the global distribution of Trichinella species and genotypes reported in wildlife, as well as reported human outbreaks from the consumption of wildlife...
August 2024: International Journal for Parasitology. Parasites and Wildlife
#35
JOURNAL ARTICLE
Alessia Bianchi, Rosa Cortese, Ferran Prados, Carmen Tur, Baris Kanber, Marios C Yiannakas, Rebecca Samson, Floriana De Angelis, Lise Magnollay, Anu Jacob, Wallace Brownlee, Anand Trip, Richard Nicholas, Yael Hacohen, Frederik Barkhof, Olga Ciccarelli, Ahmed T Toosy
BACKGROUND: Optic neuritis (ON) is a common feature of inflammatory demyelinating diseases (IDDs) such as multiple sclerosis (MS), aquaporin 4-antibody neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). However, the involvement of the optic chiasm (OC) in IDD has not been fully investigated. AIMS: To examine OC differences in non-acute IDD patients with (ON+) and without ON (ON-) using magnetisation transfer ratio (MTR), to compare differences between MS, AQP4 + NMOSD and MOGAD and understand their associations with other neuro-ophthalmological markers...
April 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
#36
Amy Samson, Shaegan Irusen
An HIV-negative 9-year-old female was admitted to the pediatric ward at a tertiary hospital in Johannesburg, South Africa for investigation of a suspected rheumatic disorder complicated by proteinuria. She was subsequently diagnosed with pediatric systemic lupus erythematosus complicated by class IV lupus nephritis. Further into her admission, the patient developed hospital-acquired SARS-CoV-2 infection with mild clinical symptoms. Three weeks after her initial COVID-19 diagnosis, the patient developed multisystemic inflammatory syndrome...
2024: Indian Journal of Nephrology
#37
JOURNAL ARTICLE
Elisabeth Lindström, Cecilia Lundström, Anders Sand, Ineke Samson
AIM: Stuttering is a communication disorder that involves both manifest speech disfluencies and associated symptoms. The purpose of the present study was to introduce an easily administered and ecologically valid assessment tool designed for perceptual evaluation of stuttered speech, FreDESS (frequency of stuttering events, duration of events, effort, secondary behaviours, and severity). More specifically, we wanted to study its reliability and validity. METHOD: Video recordings of conversations with 38 people who stutter (PWS), 19 females and 19 males aged 13-25, were assessed by three speech language pathologists (SLP)...
April 21, 2024: Logopedics, Phoniatrics, Vocology
#38
REVIEW
Aneesh Dhore-Patil, Daniela Urina-Jassir, Rohan Samson, Thierry H Le Jemtel, Suzanne Oparil
PURPOSE OF THE REVIEW: Preserved ejection fraction heart failure and obesity frequently coexist. Whether obesity plays a consistent role in the pathogenesis of preserved ejection fraction heart failure is unclear. Accumulation of visceral adiposity underlies the pathogenic aftermaths of obesity. However, visceral adiposity imaging is assessed by computed tomography or magnetic resonance and thus not routinely available. In contrast, epicardial adiposity thickness is assessed by echocardiography and thus routinely available...
April 20, 2024: Current Hypertension Reports
#39
JOURNAL ARTICLE
Fisseha Shiferie, Samson Gebremedhin, Gashaw Andargie, Frank DelPizzo, Kidist Belete, Teferi Gedif Fenta
BACKGROUND: Ethiopia is the fourth leading contributor to the global total of zero-dose children (those who lack the first dose of diphtheria-tetanus-pertussis containing vaccine) and has substantial regional variations in zero-dose children. This study explored the spatial pattern of zero-dose children aged 12-35 months in Ethiopia. METHODS: A survey was conducted in pastoralist regions, developing regions, newly-established regions, conflict-affected areas, underserved urban populations, hard-to-reach areas, internally displaced populations, and refugees...
2024: Frontiers in Pediatrics
#40
Samson Dires Gashaw, Waltengus Demissie Birhanu, Fitsum Alemayehu
BACKGROUND: Intranasal mucosal melanoma is a rare form of melanoma. Presenting as the features of occult malignancy and rapid in its progression. Presented with nonspecific symptoms. So far, no specific risk factor has been identified. The histopathological and immunohistochemical examination helps to confirm the diagnosis. Here, we present a case of primary intranasal melanotic mucosal melanoma and literature review. CASE REPORT: The authors present a patient with primary right intranasal melanotic mucosal melanoma...
2024: International Medical Case Reports Journal
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