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https://www.readbyqxmd.com/read/29777362/the-silver-effect-of-admission-glucose-level-on-excellent-outcome-in-thrombolysed-stroke-patients
#1
Charlotte Rosso, Flore Baronnet, Belen Diaz, Raphael Le Bouc, Giulia Frasca Polara, Eric Jr Moulton, Sandrine Deltour, Anne Leger, Sophie Crozier, Yves Samson
Higher admission glucose levels (AGL) are associated with less favorable outcome in thrombolysis. But, could AGL's impact on outcome vary by onset-to-treatment (OTT) time? Is hyperglycemia associated with a shorter therapeutic time window for excellent outcome for thrombolysed stroke patients? We assessed predictive values of AGL, baseline NIHSS, age, and OTT time quartiles on excellent outcome (3-month modified Rankin score of 0-1) in 773 patients treated by rt-Pa. We added the AGL × OTT time quartile interaction in the model and separately analyzed the predictive values of AGL, age, and NIHSS for each OTT time quartile if the interaction was significant...
May 18, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29774823/endoscopic-management-of-upper-urinary-tract-urothelial-carcinoma
#2
Patrick Samson, Arthur D Smith, David Hoenig, Zeph Okeke
INTRODUCTION: Endoscopic management of upper tract urothelial carcinoma has become more popular over the last few decades as there has been an impetus for renal preservation in these patients. While radical nephroureterectomy has been the gold standard in treatment of this disease, ureteroscopic and percutaneous management has become a viable option for select patients. METHODS AND MATERIALS: The literature on endoscopic management of upper urinary tract tumors was explored...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29774510/recruiting-filipino-immigrants-in-a-randomized-controlled-trial-promoting-enrollment-in-an-evidence-based-parenting-intervention
#3
Joyce R Javier, Angela Reyes, Dean M Coffey, Sheree M Schrager, Allan Samson, Lawrence Palinkas, Michele D Kipke, Jeanne Miranda
Filipinos, the second largest Asian subgroup in the U.S., experience significant youth behavioral health disparities but remain under-represented in health research. We describe lessons learned from using the Matching Model of Recruitment to recruit 215 Filipinos to participate in a large, randomized controlled trial of a culturally tailored video aimed at increasing enrollment in the Incredible Years® Parent Program. We recruited participants from schools, churches, clinics, community events, and other community-based locations...
May 17, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29774130/targeting-invadopodia-mediated-breast-cancer-metastasis-by-using-abl-kinase-inhibitors
#4
Tomer Meirson, Alessandro Genna, Nikola Lukic, Tetiana Makhnii, Joel Alter, Ved P Sharma, Yarong Wang, Abraham O Samson, John S Condeelis, Hava Gil-Henn
Metastatic dissemination of cancer cells from the primary tumor and their spread to distant sites in the body is the leading cause of mortality in breast cancer patients. While researchers have identified treatments that shrink or slow metastatic tumors, no treatment that permanently eradicates metastasis exists at present. Here, we show that the ABL kinase inhibitors imatinib, nilotinib, and GNF-5 impede invadopodium precursor formation and cortactin-phosphorylation dependent invadopodium maturation, leading to decreased actin polymerization in invadopodia, reduced extracellular matrix degradation, and impaired matrix proteolysis-dependent invasion...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29774083/engineered-microfluidic-bioreactor-for-examining-the-three-dimensional-breast-tumor-microenvironment
#5
Matthew Rogers, Tammy Sobolik, David K Schaffer, Philip C Samson, Andrew C Johnson, Philip Owens, Simona G Codreanu, Stacy D Sherrod, John A McLean, John P Wikswo, Ann Richmond
The interaction of cancer cells with the stromal cells and matrix in the tumor microenvironment plays a key role in progression to metastasis. A better understanding of the mechanisms underlying these interactions would aid in developing new therapeutic approaches to inhibit this progression. Here, we describe the fabrication of a simple microfluidic bioreactor capable of recapitulating the three-dimensional breast tumor microenvironment. Cancer cell spheroids, fibroblasts, and endothelial cells co-cultured in this device create a robust microenvironment suitable for studying in real time the migration of cancer cells along matrix structures laid down by fibroblasts within the 3D tumor microenvironment...
May 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29771560/khat-withdrawal-symptoms-among-chronic-khat-users-following-a-quit-attempt-an-ecological-momentary-assessment-study
#6
Samson W Duresso, Raimondo Bruno, Allison J Matthews, Stuart G Ferguson
Research reports show increased prevalence of habitual khat chewing among various parts of the community in Ethiopia. Some users experience problems controlling their use; withdrawal symptoms may be adding to difficulties with reducing or ceasing use. We aimed to describe the nature and the time course of any withdrawal syndrome in relation to the cessation of khat use over the first 2 weeks of a quit attempt. Fifty-nine participants between the ages of 18 and 35 and who have already chewed ≥1 bundle of khat in their life with a chewing frequency of ≥3 days per week were recruited from Adama Science and Technology University campus...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29771350/accuracy-of-the-medication-list-in-the-electronic-health-record-implications-for-care-research-and-improvement
#7
Kathleen E Walsh, Keith A Marsolo, Cori Davis, Theresa Todd, Bernadette Martineau, Carlie Arbaugh, Frederique Verly, Charles Samson, Peter Margolis
Objective: Electronic medication lists may be useful in clinical decision support and research, but their accuracy is not well described. Our aim was to assess the completeness of the medication list compared to the clinical narrative in the electronic health record. Methods: We reviewed charts of 30 patients with inflammatory bowel disease (IBD) from each of 6 gastroenterology centers. Centers compared IBD medications from the medication list to the clinical narrative...
May 15, 2018: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29769582/mathematical-models-of-human-mobility-of-relevance-to-malaria-transmission-in-africa
#8
John M Marshall, Sean L Wu, Hector M Sanchez C, Samson S Kiware, Micky Ndhlovu, André Lin Ouédraogo, Mahamoudou B Touré, Hugh J Sturrock, Azra C Ghani, Neil M Ferguson
As Africa-wide malaria prevalence declines, an understanding of human movement patterns is essential to inform how best to target interventions. We fitted movement models to trip data from surveys conducted at 3-5 sites throughout each of Mali, Burkina Faso, Zambia and Tanzania. Two models were compared in terms of their ability to predict the observed movement patterns - a gravity model, in which movement rates between pairs of locations increase with population size and decrease with distance, and a radiation model, in which travelers are cumulatively "absorbed" as they move outwards from their origin of travel...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768503/high-uptake-of-antiretroviral-therapy-among-hiv-positive-tb-patients-receiving-co-located-services-in-swaziland
#9
Ishani Pathmanathan, Munyaradzi Pasipamire, Sherri Pals, E Kainne Dokubo, Peter Preko, Trong Ao, Sikhathele Mazibuko, Janet Ongole, Themba Dhlamini, Samson Haumba
BACKGROUND: Swaziland has the highest adult HIV prevalence and second highest rate of TB/HIV coinfection globally. Recently, the Ministry of Health and partners have increased integration and co-location of TB/HIV services, but the timing of antiretroviral therapy (ART) relative to TB treatment-a marker of program quality and predictor of outcomes-is unknown. METHODS: We conducted a retrospective analysis of programmatic data from 11 purposefully-sampled facilities to evaluate timely ART provision for HIV-positive TB patients enrolled on TB treatment between July-November 2014...
2018: PloS One
https://www.readbyqxmd.com/read/29765589/non-union-of-the-trapezium-rare-consequence-of-a-rare-injury
#10
Deepak Samson, Matthew Jones, Andrew Mahon
Fractures of the trapezium are rare and easily missed. As these injuries are often imperceptible on plain radiographs, diagnosis in the ED setting is challenging. We report a case of an isolated fracture of the trapezium which was picked up as a non-union 5 months after the injury following persistence of symptoms.
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29759976/missed-opportunities-for-prevention-of-vertical-hiv-transmission-in-canada-1997-2016-a-surveillance-study
#11
Ari Bitnun, Terry Lee, Jason Brophy, Lindy M Samson, Fatima Kakkar, Wendy Vaudry, Ben Tan, Deborah M Money, Joel Singer, Laura J Sauvé, Ariane Alimenti
BACKGROUND: Vertical HIV transmission has declined in Canada, but missed opportunities for prevention continue to occur. We sought to determine the adequacy, and changes over time in adequacy, of uptake of maternal and neonatal antiretroviral therapy for the prevention of vertical HIV transmission, and to determine the vertical transmission rate over time and according to adequacy of antenatal antiretroviral therapy during the combination antiretroviral therapy era in Canada. METHODS: The Canadian Perinatal HIV Surveillance Program collects data annually through retrospective chart review concerning HIV-infected women and their infants...
May 10, 2018: CMAJ Open
https://www.readbyqxmd.com/read/29759437/cleaning-and-sterilization-of-used-cardiac-implantable-electronic-devices-with-process-validation-the-next-hurdle-in-device-recycling
#12
Thomas C Crawford, Craig Allmendinger, Jay Snell, Kevin Weatherwax, Balasundaram Lavan, Timir S Baman, Pat Sovitch, Daniel Alyesh, Thomas Carrigan, Noah Klugman, Denis Kune, Andrew Hughey, Daniel Lautenbach, Nathan Sovitch, Karman Tandon, George Samson, Charles Newman, Sheldon Davis, Archie Brown, Brad Wasserman, Ed Goldman, Sandra L Arlinghaus, Hakan Oral, Kim A Eagle
OBJECTIVES: This study sought to develop a validated, reproducible sterilization protocol, which could be used in the reprocessing of cardiac implantable electronic devices (CIEDs). BACKGROUND: Access to cardiac CIED therapy in high-income and in low- and middle-income countries varies greatly. CIED reuse may reduce this disparity. METHODS: A cleaning and sterilization protocol was developed that includes washing CIEDs in an enzymatic detergent, screw cap and set screw replacement, brushing, inspection, and sterilization in ethylene oxide...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29752729/conservation-lessons-from-large-mammal-manipulations-in-east-african-savannas-the-klee-uhuru-and-glade-experiments
#13
REVIEW
Jacob R Goheen, David J Augustine, Kari E Veblen, Duncan M Kimuyu, Todd M Palmer, Lauren M Porensky, Robert M Pringle, Jayashree Ratnam, Corinna Riginos, Mahesh Sankaran, Adam T Ford, Abdikadir A Hassan, Rhiannon Jakopak, Tyler R Kartzinel, Samson Kurukura, Allison M Louthan, Wilfred O Odadi, Tobias O Otieno, Alois M Wambua, Hillary S Young, Truman P Young
African savannas support an iconic fauna, but they are undergoing large-scale population declines and extinctions of large (>5 kg) mammals. Long-term, controlled, replicated experiments that explore the consequences of this defaunation (and its replacement with livestock) are rare. The Mpala Research Centre in Laikipia County, Kenya, hosts three such experiments, spanning two adjacent ecosystems and environmental gradients within them: the Kenya Long-Term Exclosure Experiment (KLEE; since 1995), the Glade Legacies and Defaunation Experiment (GLADE; since 1999), and the Ungulate Herbivory Under Rainfall Uncertainty experiment (UHURU; since 2008)...
May 11, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29751785/low-birth-weight-among-term-newborns-in-wolaita-sodo-town-south-ethiopia-a-facility-based-cross-sectional-study
#14
Samson Kastro, Tsegaye Demissie, Bereket Yohannes
BACKGROUND: In low income countries, many low birth weight newborns often miss the chance for survival sooner or later. Others who survive would also face increased risks in later life. Though not adequately documented in Ethiopia, maternal factors pose the main risk. This study was aimed to estimate the proportion of low birth weight among term singletons without congenital malformations and factors associated with it in Wolaita Sodo town in South Ethiopia. METHODS: We did a facility based survey involving 432 postpartum women with their term newborns...
May 11, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29747048/a-randomized-trial-examining-a-physical-activity-intervention-for-the-prevention-of-postpartum-depression-the-healthy-mom-trial
#15
Beth A Lewis, Katie Schuver, Shira Duniger, Lauren Samson, Amanda L Frayeh, Carrie A Terrell, Joe T Ciccolo, Melissa D Avery
Approximately 13-19% of women experience postpartum depression and approximately one-third of women who have a history of depression develop depression during the postpartum phase. Exercise is an efficacious intervention for depression among adults; however, few studies have examined the effect of exercise on postpartum depression. The purpose of this study was to conduct a randomized controlled trial examining the effect of exercise and wellness interventions on preventing postpartum depression among women at risk...
May 7, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29746905/chronic-lead-exposure-induces-cochlear-oxidative-stress-and-potentiates-noise-induced-hearing-loss
#16
Samson Jamesdaniel, Rita Rosati, Judy Westrick, Douglas M Ruden
Acquired hearing loss is caused by complex interactions of multiple environmental risk factors, such as elevated levels of lead and noise, which are prevalent in urban communities. This study delineates the mechanism underlying lead-induced auditory dysfunction and its potential interaction with noise exposure. Young-adult C57BL/6 mice were exposed to: 1) control conditions; 2) 2 mM lead acetate in drinking water for 28 days; 3) 90 dB broadband noise 2 h/day for two weeks; and 4) both lead and noise...
May 7, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29744654/assessment-of-tobacco-smoke-effects-on-neonatal-cardiorespiratory-control-using-a-semi-automated-processing-approach
#17
Sally Al-Omar, Virginie Le Rolle, Alain Beuchée, Nathalie Samson, Jean-Paul Praud, Guy Carrault
A semi-automated processing approach was developed to assess the effects of early postnatal environmental tobacco smoke (ETS) on the cardiorespiratory control of newborn lambs. The system consists of several steps beginning with artifact rejection, followed by the selection of stationary segments, and ending with feature extraction. This approach was used in six lambs exposed to 20 cigarettes/day for the first 15 days of life, while another six control lambs were exposed to room air. On postnatal day 16, electrocardiograph and respiratory signals were obtained from a 6-h polysomnographic recording...
May 10, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29739926/maldi-tof-ms-for-identification-of-tsukamurella-species-tsukamurella-tyrosinosolvens-as-the-predominant-species-associated-with-ocular-infections
#18
Jade L L Teng, Ying Tang, Samson S Y Wong, Jordan Y H Fong, Zhe Zhao, Chun-Pong Wong, Jonathan H K Chen, Antonio H Y Ngan, Alan K L Wu, Kitty S C Fung, Tak-Lun Que, Susanna K P Lau, Patrick C Y Woo
Although Tsukamurella infections have been increasingly reported in Europe, Asia, America, and Africa, indicating that diseases caused by this group of bacteria are emerging in a global scale, species identification within this genus is difficult in most clinical microbiology laboratories. Recently, we showed that groEL gene sequencing is useful for identification of all existing Tsukamurella species. Nevertheless, PCR sequencing is still considered expensive, time-consuming, and technically demanding, and therefore is yet to be incorporated as a routine identification method in clinical laboratories...
May 9, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29736026/arid1a-deficiency-promotes-mutability-and-potentiates-therapeutic-antitumor-immunity-unleashed-by-immune-checkpoint-blockade
#19
Jianfeng Shen, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng, Zhongqi Ge, Zachary D Nagel, Jun Zou, Chen Wang, Prabodh Kapoor, Xiangyi Ma, Ding Ma, Jiyong Liang, Shumei Song, Jinsong Liu, Leona D Samson, Jaffer A Ajani, Guo-Min Li, Han Liang, Xuetong Shen, Gordon B Mills, Guang Peng
ARID1A (the AT-rich interaction domain 1A, also known as BAF250a) is one of the most commonly mutated genes in cancer1,2 . The majority of ARID1A mutations are inactivating mutations and lead to loss of ARID1A expression 3 , which makes ARID1A a poor therapeutic target. Therefore, it is of clinical importance to identify molecular consequences of ARID1A deficiency that create therapeutic vulnerabilities in ARID1A-mutant tumors. In a proteomic screen, we found that ARID1A interacts with mismatch repair (MMR) protein MSH2...
May 7, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29729742/inkjet-printing-based-%C3%AE-secretase-fluorescence-resonance-energy-transfer-fret-assay-for-screening-of-potential-%C3%AE-secretase-inhibitors-of-alzheimer-s-disease
#20
Jungmi Lee, Annie Agnes Suganya Samson, Joon Myong Song
Amyloid-β (Aβ) is generated by proteolytic processing of amyloid precursor protein (APP) by beta-secretase (BACE-1) and gamma-secretase. Amyloid-β is responsible for the formation of senile plaques in Alzheimer's disease (AD). Consequently, inhibition of β-secretase (BACE-1), a rate-limiting enzyme in the production of Aβ, constitutes an attractive therapeutic approach to the treatment of AD. This paper reports an inkjet printing-based fluorescence assay for high throughput screening of β-secretase inhibitors achieved by employing a BACE-1 FRET substrate (Rh-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-Quencher)...
August 31, 2018: Analytica Chimica Acta
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