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https://www.readbyqxmd.com/read/28645331/circadian-clock-gene-polymorphisms-in-relation-to-sleep-patterns-and-obesity-in-african-americans-findings-from-the-jackson-heart-study
#1
Pia Riestra, Samson Y Gebreab, Ruihua Xu, Rumana J Khan, Amadou Gaye, Adolfo Correa, Nancy Min, Mario Sims, Sharon K Davis
BACKGROUND: Circadian rhythms regulate key biological processes and the dysregulation of the intrinsic clock mechanism affects sleep patterns and obesity onset. The CLOCK (circadian locomotor output cycles protein kaput) gene encodes a core transcription factor of the molecular circadian clock influencing diverse metabolic pathways, including glucose and lipid homeostasis. The primary objective of this study was to evaluate the associations between CLOCK single nucleotide polymorphisms (SNPs) and body mass index (BMI)...
June 23, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28644511/bacteriophage-tail-tube-assembly-studied-by-proton-detected-4d-solid-state-nmr
#2
Maximilian Zinke, Pascal Fricke, Camille Samson, Songhwan Hwang, Joseph Wall, Sascha Lange, Sophie Zinn-Justin, Adam Lange
Obtaining unambiguous resonance assignments remains a major bottleneck in solid-state NMR studies of protein structure and dynamics. Particularly for supramolecular assemblies with large subunits (>150 residues), the analysis of crowded spectral data presents a challenge, even if three-dimensional (3D) spectra are used. Here, we present a proton-detected 4D solid-state NMR assignment procedure that is tailored for large assemblies. The key to recording 4D spectra with three indirect carbon or nitrogen dimensions with their inherently large chemical shift dispersion lies in the use of sparse non-uniform sampling (as low as 2%)...
June 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28642589/multiple-origins-and-a-narrow-genepool-characterise-the-african-tea-germplasm-concordant-patterns-revealed-by-nuclear-and-plastid-dna-markers
#3
Moses Cheloti Wambulwa, Muditha Kasun Meegahakumbura, Samson Kamunya, Alice Muchugi, Michael Möller, Jie Liu, Jian-Chu Xu, De-Zhu Li, Lian-Ming Gao
Despite the highly economic value of tea in Africa, its genetic and geographic origins remain largely unexplored. Here we address this by collecting 439 samples across 11 countries in Africa and Asia to investigate the origin and genepool composition of African tea based on 23 nuclear microsatellites loci (nSSRs) and three cpDNA intergenic spacer regions. Our results indicated that the African tea represents a potpourri originating from multiple introductions over time. The nSSR analysis revealed that the majority (79%) of tea accessions collected in Africa belong to Indian Assam tea which have likely originated from India and/or Sri Lanka...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28641599/association-between-level-of-exposure-to-death-and-dying-and-professional-quality-of-life-among-palliative-care-workers
#4
Tali Samson, Pesach Shvartzman
BACKGROUND: Exposure to the death and dying of others is an anxiety-provoking condition that can contribute to psychological stress. However, the results of empirical studies that evaluated work-related outcomes among physicians and nurses with repeated exposure to dying patients are not consistent. OBJECTIVE: Our aim was to evaluate whether a high level of exposure to death and dying (LED) can increase the risk for poor professional quality of life (ProQoL) in most healthcare workers, but it can also improve ProQoL in a subset of healthcare workers with specific characteristics...
June 23, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28630942/antimalarial-drugs-and-the-prevalence-of-mental-and-neurological-manifestations-a-systematic-review-and-meta-analysis
#5
Mary A Bitta, Symon M Kariuki, Clifford Mwita, Samson Gwer, Leah Mwai, Charles R J C Newton
Background: Antimalarial drugs affect the central nervous system, but it is difficult to differentiate the effect of these drugs from that of the malaria illness. We conducted a systematic review to determine the association between anti-malarial drugs and mental and neurological impairment in humans.  Methods: We systematically searched online databases, including Medline/PubMed, PsychoInfo, and Embase, for articles published up to 14th July 2016. Pooled prevalence, heterogeneity and factors associated with prevalence of mental and neurological manifestations were determined using meta-analytic techniques...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28628000/epigenetics-inflammation-and-metabolism-in-right-heart-failure-associated-with-pulmonary-hypertension
#6
Nolwenn Samson, Roxane Paulin
Right ventricular failure (RVF) is the most important prognostic factor for both morbidity and mortality in pulmonary arterial hypertension (PAH), but also occurs in numerous other common diseases and conditions, including left ventricle dysfunction. RVF remains understudied compared with left ventricular failure (LVF). However, right and left ventricles have many differences at the morphological level or the embryologic origin, and respond differently to pressure overload. Therefore, knowledge from the left ventricle cannot be extrapolated to the right ventricle...
June 19, 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28620934/fairness-in-cost-benefit-analysis-a-methodology-for-health-technology-assessment
#7
Anne-Laure Samson, Erik Schokkaert, Clémence Thébaut, Brigitte Dormont, Marc Fleurbaey, Stéphane Luchini, Carine Van de Voorde
We evaluate the introduction of various forms of antihypertensive treatments in France with a distribution-sensitive cost-benefit analysis. Compared to traditional cost-benefit analysis, we implement distributional weighting based on equivalent incomes, a new concept of individual well-being that does respect individual preferences but is not subjectively welfarist. Individual preferences are estimated on the basis of a contingent valuation question, introduced into a representative survey of the French population...
June 16, 2017: Health Economics
https://www.readbyqxmd.com/read/28611297/endogenous-il-33-has-no-effect-on-the-progression-of-fibrosis-during-experimental-steatohepatitis
#8
Philippe Vasseur, Sarah Dion, Aveline Filliol, Valentine Genet, Catherine Lucas-Clerc, Girard Jean-Philippe, Christine Silvain, Jean-Claude Lecron, Claire Piquet-Pellorce, Michel Samson
Interleukin (IL)-33 has been recently reported to be strongly pro-fibrogenic in various models of liver disease. Our aim was to study the role of endogenous IL-33 in a diet-induced model of steatohepatitis. IL-33 deficient mice and wild type (WT) littermates received a high-fat diet (HFD), or a standard diet for 12 weeks. The HFD-induced steatohepatitis was associated with an upregulation of IL-33 transcripts and protein. An insulin tolerance test revealed lower systemic insulin sensitivity in IL-33-/-HFD mice than in WT-HFD mice...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28609658/a-systems-biology-approach-identifies-fut8-as-a-driver-of-melanoma-metastasis
#9
Praveen Agrawal, Barbara Fontanals-Cirera, Elena Sokolova, Samson Jacob, Christopher A Vaiana, Diana Argibay, Veronica Davalos, Meagan McDermott, Shruti Nayak, Farbod Darvishian, Mireia Castillo, Beatrix Ueberheide, Iman Osman, David Fenyö, Lara K Mahal, Eva Hernando
Association of aberrant glycosylation with melanoma progression is based mainly on analyses of cell lines. Here we present a systems-based study of glycomic changes and corresponding enzymes associated with melanoma metastasis in patient samples. Upregulation of core fucosylation (FUT8) and downregulation of α-1,2 fucosylation (FUT1, FUT2) were identified as features of metastatic melanoma. Using both in vitro and in vivo studies, we demonstrate FUT8 is a driver of melanoma metastasis which, when silenced, suppresses invasion and tumor dissemination...
June 12, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28607531/endogenous-il-33-deficiency-exacerbates-liver-injury-and-increases-hepatic-influx-of-neutrophils-in-acute-murine-viral-hepatitis
#10
Virginie Carrière, Muhammad Imran Arshad, Jacques Le Seyec, Benjamin Lefevre, Muhammad Farooq, Aurélien Jan, Christelle Manuel, Laurence Touami-Bernard, Catherine Lucas-Clerc, Valentine Genet, Hugues Gascan, Jean-Philippe Girard, Frédéric Chalmel, Lucie Lamontagne, Claire Piquet-Pellorce, Michel Samson
The alarmin IL-33 has been described to be upregulated in human and murine viral hepatitis. However, the role of endogenous IL-33 in viral hepatitis remains obscure. We aimed to decipher its function by infecting IL-33-deficient mice (IL-33 KO) and their wild-type (WT) littermates with pathogenic mouse hepatitis virus (L2-MHV3). The IL-33 KO mice were more sensitive to L2-MHV3 infection exhibiting higher levels of AST/ALT, higher tissue damage, significant weight loss, and earlier death. An increased depletion of B and T lymphocytes, NKT cells, dendritic cells, and macrophages was observed 48 h postinfection (PI) in IL-33 KO mice than that in WT mice...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28605967/book-review-deplazes-p-eckert-j-mathis-a-von-samson-himmelstjerna-g-and-zahner-h-parasitology-in-veterinary-medicine-wageningen-academic-publishers-wageningen-2016-656-pages-421-figures-of-which-56-are-life-cycle-schemes-of-parasite-species-113-tables-19-5
#11
https://www.readbyqxmd.com/read/28597109/race-specific-associations-between-health-related-quality-of-life-and-cellular-aging-among-adults-in-the-united-states-evidence-from-the-national-health-and-nutrition-examination-survey
#12
Rumana J Khan, Samson Y Gebreab, Pia R Crespo, Ruihua Xu, Amadou Gaye, Sharon K Davis
PURPOSE: Poor health-related quality of life (HRQOL) could lead to higher morbidity and mortality through telomere attrition or accelerated cellular aging. We conducted a cross-sectional analysis to examine the relationship between four dimensions of HRQOL and leukocyte telomere length (LTL) among a nationally representative sample of 3547 US adults (≥20 years) using the data from the 2001-2002 National Health and Nutrition Examination Survey. METHOD: We used HRQOL survey information collected on individuals' self-rated general health, recent physical health, recent mental health, and recent activity limitation...
June 8, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28593684/thyroglobulin-level-at-week-16-of-pregnancy-is-superior-to-urinary-iodine-concentration-in-revealing-preconceptual-and-first-trimester-iodine-supply
#13
Monika Katko, Andrea Anett Gazso, Ildiko Hircsu, Harjit Pal Bhattoa, Zsuzsanna Molnar, Bela Kovacs, David Andrasi, Janos Aranyosi, Rita Makai, Lajos Veress, Olga Torok, Miklos Bodor, Laszlo Samson, Endre V Nagy
Pregnant women are prone to iodine deficiency due to the increased need for iodine during gestation. Progress has recently occurred in establishing serum thyroglobulin (Tg) as an iodine status biomarker, but there is no accepted reference range for iodine sufficiency during pregnancy. An observational study was conducted in 164 pregnant women. At week 16 of gestation urinary iodine concentration (UIC), serum Tg, and thyroid functions were measured, and information on the type of iodine supplementation and smoking were recorded...
June 7, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28592590/respite-for-2-dimensional-right-ventricular-imaging
#14
EDITORIAL
Rohan Samson, Thierry H Le Jemtel
No abstract text is available yet for this article.
June 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28589023/measuring-manipulating-and-exploiting-behaviours-of-adult-mosquitoes-to-optimise-malaria-vector-control-impact
#15
Gerry F Killeen, John M Marshall, Samson S Kiware, Andy B South, Lucy S Tusting, Prosper P Chaki, Nicodem J Govella
Residual malaria transmission can persist despite high coverage with effective long-lasting insecticidal nets (LLINs) and/or indoor residual spraying (IRS), because many vector mosquitoes evade them by feeding on animals, feeding outdoors, resting outdoors or rapidly exiting from houses after entering them. However, many of these behaviours that render vectors resilient to control with IRS and LLINs also make them vulnerable to some emerging new alternative interventions. Furthermore, vector control measures targeting preferred behaviours of mosquitoes often force them to express previously rare alternative behaviours, which can then be targeted with these complementary new interventions...
March 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28589015/going-beyond-personal-protection-against-mosquito-bites-to-eliminate-malaria-transmission-population-suppression-of-malaria-vectors-that-exploit-both-human-and-animal-blood
#16
Gerry F Killeen, Samson S Kiware, Fredros O Okumu, Marianne E Sinka, Catherine L Moyes, N Claire Massey, Peter W Gething, John M Marshall, Carlos J Chaccour, Lucy S Tusting
Protecting individuals and households against mosquito bites with long-lasting insecticidal nets (LLINs) or indoor residual spraying (IRS) can suppress entire populations of unusually efficient malaria vector species that predominantly feed indoors on humans. Mosquitoes which usually feed on animals are less reliant on human blood, so they are far less vulnerable to population suppression effects of such human-targeted insecticidal measures. Fortunately, the dozens of mosquito species which primarily feed on animals are also relatively inefficient vectors of malaria, so personal protection against mosquito bites may be sufficient to eliminate transmission...
March 2017: BMJ Global Health
https://www.readbyqxmd.com/read/28588990/cognitive-capital-equity-and-child-sensitive-social-protection-in-asia-and-the-pacific
#17
Michael Samson, Gaspar Fajth, Daphne François
Promoting child development and welfare delivers human rights and builds sustainable economies through investment in 'cognitive capital'. This analysis looks at conditions that support optimal brain development in childhood and highlights how social protection promotes these conditions and strengthens the achievement of the Sustainable Development Goals (SDGs) in Asia and the Pacific. Embracing child-sensitive social protection offers multiple benefits. The region has been a leader in global poverty reduction but the underlying pattern of economic growth exacerbates inequality and is increasingly unsustainable...
November 2016: BMJ Global Health
https://www.readbyqxmd.com/read/28587814/motion-energy-analysis-reveals-altered-body-movement-in-youth-at-risk-for-psychosis
#18
Derek J Dean, Alayna T Samson, Raeana Newberry, Vijay A Mittal
BACKGROUND: Growing evidence suggests that movement abnormalities occur prior to the onset of psychosis. Innovations in technology and software provide the opportunity for a fine-tuned and sensitive measurement of observable behavior that may be particularly useful to detecting the subtle movement aberrations present during the prodromal period. METHODS: In the present study, 54 youth at ultrahigh risk (UHR) for psychosis and 62 healthy controls participated in structured clinical interviews to assess for an UHR syndrome...
June 3, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28585324/identification-of-major-loci-and-genomic-regions-controlling-acid-and-volatile-content-in-tomato-fruit-implications-for-flavor-improvement
#19
Guillaume Bauchet, Stéphane Grenier, Nicolas Samson, Vincent Segura, Aniko Kende, Jules Beekwilder, Katarina Cankar, Jean-Luc Gallois, Justine Gricourt, Julien Bonnet, Charles Baxter, Laurent Grivet, Mathilde Causse
Plant metabolites are important to world food security due to their roles in crop yield and nutritional quality. Here we report the metabolic profile of 300 tomato accessions (Solanum lycopersicum and related wild species) by quantifying 60 primary and secondary metabolites, including volatile organic compounds, over a period of 2 yr. Metabolite content and genetic inheritance of metabolites varied broadly, both within and between different genetic groups. Using genotype information gained from 10 000 single nucleotide polymorphism markers, we performed a metabolite genome-wide association mapping (GWAS) study...
June 6, 2017: New Phytologist
https://www.readbyqxmd.com/read/28576343/economic-assessment-of-ostertagia-ostertagi-and-fasciola-hepatica-infections-in-dairy-cattle-herds-in-germany-using-paracalc-%C3%A2
#20
Jane Fanke, Johannes Charlier, Torsten Steppin, Georg von Samson-Himmelstjerna, Jozef Vercruysse, Janina Demeler
The aim of the current study was to estimate economic costs of Ostertagia ostertagi and Fasciola hepatica infections in dairy cattle herds in Germany using the online calculation programme Paracalc(®). Following a questionnaire, survey data were available from 464 farms in 14 federal states. On those farms bulk tank milk (BTM) samples and additionally up to six serum samples collected from first season grazing calves were analysed, using a commercially available ELISA (Boehringer Ingelheim SVANOVA Biotech AB, Uppsala, Sweden), an in-house ELISA (F...
June 15, 2017: Veterinary Parasitology
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