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https://www.readbyqxmd.com/read/28917337/29-hyperparathyro%C3%A3-die-primitive-chez-le-sujet-%C3%A3-g%C3%A3
#1
Ségolène Samson, Alain Jego, Nadir Kadri, Jean Doucet, Abrar-Ahmad Zulfiqar
No abstract text is available yet for this article.
September 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28916545/serologic-evidence-of-gut-driven-systemic-inflammation-in-juvenile-idiopathic-arthritis
#2
Lampros Fotis, Nurmohammad Shaikh, Kevin W Baszis, Charles M Samson, Raffi Lev-Tzion, Anthony R French, Phillip I Tarr
OBJECTIVE: Accumulating evidence links juvenile idiopathic arthritis (JIA) to nonhost factors such as gut microbes. We hypothesize that children with new-onset JIA have increased intestinal bacterial translocation and circulating lipopolysaccharide (LPS). METHODS: We studied systemic treatment-naive patients with JIA [polyarticular JIA, n = 22, oligoarticular JIA, n = 31, and spondyloarthropathies (SpA), n = 16], patients with established inflammatory bowel disease-related arthritis (IBD-RA, n = 11), and 34 healthy controls...
September 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28915796/correlates-of-isoniazid-preventive-therapy-failure-in-child-household-contacts-with-infectious-tuberculosis-in-high-burden-settings-in-nairobi-kenya-a-cohort-study
#3
Florence Nafula Okwara, John Paul Oyore, Fred Nabwire Were, Samson Gwer
BACKGROUND: Sub-Saharan Africa continues to document high pediatric tuberculosis (TB) burden, especially among the urban poor. One recommended preventive strategy involves tracking and isoniazid preventive therapy (IPT) for children under 5 years in close contact with infectious TB. However, sub-optimal effectiveness has been documented in diverse settings. We conducted a study to elucidate correlates to IPT strategy failure in children below 5 years in high burden settings. METHODS: A prospective longitudinal cohort study was done in informal settlings in Nairobi, where children under 5 years in household contact with recently diagnosed smear positive TB adults were enrolled...
September 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28915275/long-term-efficacy-and-safety-of-rituximab-in-igg4-related-disease-data-from-a-french-nationwide-study-of-thirty-three-patients
#4
Mikael Ebbo, Aurélie Grados, Maxime Samson, Matthieu Groh, Anderson Loundou, Aude Rigolet, Benjamin Terrier, Constance Guillaud, Clarisse Carra-Dallière, Frédéric Renou, Agnieszka Pozdzik, Pierre Labauge, Sylvain Palat, Jean-Marie Berthelot, Jean-Loup Pennaforte, Alain Wynckel, Céline Lebas, Noémie Le Gouellec, Thomas Quémeneur, Karine Dahan, Franck Carbonnel, Gaëlle Leroux, Antoinette Perlat, Alexis Mathian, Patrice Cacoub, Eric Hachulla, Nathalie Costedoat-Chalumeau, Jean-Robert Harlé, Nicolas Schleinitz
OBJECTIVES: To assess efficacy and safety of rituximab (RTX) as induction therapy, maintenance of remission and treatment of relapses in a cohort of IgG4-related disease (IgG4-RD) patients. METHODS: Nationwide retrospective multicenter study of IgG4-RD patients treated with at least one course of RTX. Clinical, biological and radiological response, relapse rate and drug tolerance were analyzed. Kaplan-Meier curves were plotted and risk factors for relapse studied with a Cox regression model...
2017: PloS One
https://www.readbyqxmd.com/read/28910489/nucleoside-nucleotide-reverse-transcriptase-inhibitors-attenuate-angiogenesis-and-lymphangiogenesis-by-impairing-receptor-tyrosine-kinases-signalling-in-endothelial-cells
#5
Lin Song, Sha Ding, Zhen Ge, Xiaolong Zhu, Cong Qiu, Yuewen Wang, Enyin Lai, Weijun Yang, Yi Sun, Samson A Chow, Luyang Yu
BACKGROUND AND PURPOSE: Cardiovascular disease associated with antiretroviral therapy (ART) has become a major clinical challenge for HIV-positive patients. However, the role of ART in blood vessel growth is largely unknown. Here, we examined an integral component of ART, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), and investigated their effects on key microvascular functions, including angiogenesis and lymphangiogenesis. EXPERIMENTAL APPROACH: The angiogenesis/lymphangiogenesis capability of endothelial cells (ECs) was evaluated using migration, proliferation and tube formation assays in vitro, and mouse ear and Matrigel plug assays in vivo...
September 14, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28899646/early-life-adversity-potentiates-expression-of-addiction-related-traits
#6
Tristan J Hynes, Catherine S Thomas, Alicia S Zumbusch, Anna Samson, Ioana Petriman, Una Mrdja, Angelique Orr, Emilie Cutts, Bruce G Ruzindana, Alimohamed Hazari, Margaret Zjadewicz, Vedran Lovic
Many individuals sporadically and circumstantially sample addictive drugs, yet few become addicted. The individual vulnerabilities underlying the development of addiction are not well understood. Correlational findings show that early life adversity is associated with a greater propensity to develop drug addiction. However, the mechanisms by which early life adversity increases addiction vulnerability are unknown. Separate lines of research have found that several traits are associated with addiction. Here, we examined the effects of early life adversity on addiction-related traits in adulthood...
September 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28899053/intracranial-meningiomas-in-the-era-of-human-immunodeficiency-virus-infection-and-antiretroviral-therapies-in-kwazulu-natal-south-africa-an-observational-case-control-study
#7
Mogwale Samson Motebejane, Ian Kaminsky, Basil Claude Enicker, Tonya Esterhuizen, In Sup Choi
No abstract text is available yet for this article.
September 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28895288/association-between-hiv-and-blood-pressure-in-adults-and-role-of-body-weight-as-a-mediator-cross-sectional-study-in-uganda
#8
Samson Okello, Peter Ueda, Michael Kanyesigye, Emmanuel Byaruhanga, Achilles Kiyimba, Gideon Amanyire, Alex Kintu, Wafaie W Fawzi, Winnie R Muyindike, Goodarz Danaei
The authors sought to describe the association between human immunodeficiency virus (HIV) and blood pressure (BP) levels, and determined the extent to which this relationship is mediated by body weight in a cross-sectional study of HIV-infected and HIV-uninfected controls matched by age, sex, and neighborhood. Mixed-effects models were fit to determine the association between HIV and BP and amount of effect of HIV on BP mediated through body mass index. Data were analyzed from 577 HIV-infected and 538 matched HIV-uninfected participants...
September 12, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28893906/n-terminal-splicing-extensions-of-the-human-myo1c-gene-fine-tune-the-kinetics-of-the-three-full-length-myosin-ic-isoforms
#9
Lilach Zattelman, Ronit Regev, Marko Ušaj, Patrick Y A Reinke, Sven Giese, Abraham O Samson, Manuel H Taft, Dietmar J Manstein, Arnon Henn
The MYO1C gene produces three alternatively spliced isoforms, differing only in their N-terminal regions (NTRs). These isoforms, which exhibit both specific and overlapping nuclear and cytoplasmic functions, have different expression levels and nucleo-cytoplasmic partitioning. To investigate the effect of NTR extensions on the enzymatic behavior of individual isoforms, we over-expressed and purified the three full-length human isoforms from suspension-adapted HEK cells. MYO1C(C) favored the actomyosin closed state (AM(C)), MYO1C(16) populated the actomyosin open state (AM(O)) and AM(C) equally, and MYO1C(35) favored the AM(O) state...
September 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28893077/economic-burden-of-malaria-on-rural-households-in-gwanda-district-zimbabwe
#10
Resign Gunda, Shepherd Shamu, Moses J Chimbari, Samson Mukaratirwa
BACKGROUND: Malaria is a serious public health problem in sub-Saharan Africa and is a leading cause of morbidity and mortality. AIM: To estimate the economic burden of malaria in rural households. SETTING: The study was conducted in Gwanda district of Matabeleland South in Zimbabwe. A total of five malarious wards and all their households were selected for the study frame, out of which 80 households were chosen using clinic records. METHODS: A retrospective analysis of secondary data and a cross-sectional household survey were conducted to estimate the household economic burden of malaria...
August 28, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/28886405/emotional-recognition-of-dynamic-facial-expressions-before-and-after-cochlear-implantation-in-adults-with-progressive-deafness
#11
Emmanuèle Ambert-Dahan, Anne-Lise Giraud, Halima Mecheri, Olivier Sterkers, Isabelle Mosnier, Séverine Samson
Visual processing has been extensively explored in deaf subjects in the context of verbal communication, through the assessment of speech reading and sign language abilities. However, little is known about visual emotional processing in adult progressive deafness, and after cochlear implantation. The goal of our study was thus to assess the influence of acquired post-lingual progressive deafness on the recognition of dynamic facial emotions that were selected to express canonical fear, happiness, sadness, and anger...
August 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/28886188/alkylation-induced-cerebellar-degeneration-dependent-on-aag-and-parp1-does-not-occur-via-previously-established-cell-death-mechanisms
#12
Carrie M Margulies, Isaac Alexander Chaim, Aprotim Mazumder, June Criscione, Leona D Samson
Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs primarily through the base excision repair (BER) pathway, a multi-enzyme pathway initiated by the alkyladenine DNA glycosylase (Aag, also known as Mpg). Previous work demonstrated that mice treated with the alkylating agent methyl methanesulfonate (MMS) undergo cerebellar degeneration in an Aag-dependent manner, whereby increased BER initiation by Aag causes increased tissue damage that is dependent on activation of poly (ADP-ribose) polymerase 1 (Parp1)...
2017: PloS One
https://www.readbyqxmd.com/read/28881334/antegrade-jejunojejunal-intussusception-inside-a-retrograde-jejunogastric-intussusception-double-intussusception-a-rare-case-report
#13
Samson Ravirajendran, Sinduja Munnamgi, Akmal Abdul
INTRODUCTION: Jejunogastric intussusception through a gastrojejunal stoma along with a jejunojejunal intussusception (intussusception within an intussusception) is a rare but serious complication of previous gastric surgery such as gastrojejunostomy and Billroth II gastrectomy. The incidence of which is less than 0.1%. CASE PRESENTATION: An elderly male presented with an abdominal lump, diffuse abdominal pain and vomiting for one-day duration. Ultrasound and CECT abdomen revealed dilated stomach with jejunojejunal intussusception herniating into stomach...
August 24, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28877437/solvent-effect-on-the-third-order-nonlinear-optical-properties-of-%C3%AE-and-%C3%AE-tertbutyl-phenoxy-substituted-tin-iv-chloride-phthalocyanines
#14
Marcel Louzada, Jonathan Britton, Tebello A Nyokong, Samson Khene
This paper investigates the third order nonlinear optical properties of 4α-(4-tert-butylphenoxy) phthalocyaninato dichlorotin(IV) (α-SnOtBpPc) and 4β-(4-tert-butylphenoxy) phthalocyaninato dichlorotin(IV) (β-SnOtBpPc) in different organic solvents. The third-order susceptibilities of α-SnOtBpPc and β-SnOtBpPc are reported in different solvents, using Z-scan techniques with 10 ns laser pulses at 532 nm. Their nonlinear absorption coefficient and absorption cross sections were also determined. The molecular second-order hyperpolarizability Im(γ) of α-SnOtBpPc and β-SnOtBpPc were found to be 2...
September 6, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28873233/seasonal-variation-in-hospitalization-outcomes-in-patients-admitted-for-heart-failure-in-the-united-states
#15
Emmanuel Akintoye, Alexandros Briasoulis, Alexander Egbe, Oluwole Adegbala, Samson Alliu, Muhammad Sheikh, Manmohan Singh, Abdelrahman Ahmed, Sagar Mallikethi-Reddy, Diane Levine
BACKGROUND: There is lack of evidence of the impact of varying season on heart failure (HF) hospitalization outcomes in the U.S. HYPOTHESIS: HF hospitalization outcomes exhibit significant seasonal variation in the U.S. METHODS: Using data from the National Inpatient Sample (2011-2013), seasonal variation was classified based on meteorological classification of Northern Hemisphere-Spring, Summer, Fall, & Winter-and analysis was conducted via multivariable-adjusted mixed-effect model...
September 5, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28867394/reprint-of-modelling-the-influence-of-temperature-and-rainfall-on-malaria-incidence-in-four-endemic-provinces-of-zambia-using-semiparametric-poisson-regression
#16
Nzooma M Shimaponda-Mataa, Enala Tembo-Mwase, Michael Gebreslasie, Thomas N O Achia, Samson Mukaratirwa
Although malaria morbidity and mortality are greatly reduced globally owing to great control efforts, the disease remains the main contributor. In Zambia, all provinces are malaria endemic. However, the transmission intensities vary mainly depending on environmental factors as they interact with the vectors. Generally in Africa, possibly due to the varying perspectives and methods used, there is variation on the relative importance of malaria risk determinants. In Zambia, the role climatic factors play on malaria case rates has not been determined in combination of space and time using robust methods in modelling...
August 31, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28861680/image-retrieval-based-on-local-mesh-vector-co-occurrence-pattern-for-medical-diagnosis-from-mri-brain-images
#17
A Jenitta, R Samson Ravindran
In modern health-care, for evidence-based diagnosis, there is a requirement for an efficient image retrieval approach to retrieve the cases of interest that have similar characteristics from the large image databases. This paper presents a feature extraction approach that aims at extracting texture features present in the medical images using Local Pattern Descriptor (LPD) and Gray-level Co-occurrence Matrix (GLCM). As a main contribution, a novel local pattern named Local Mesh Vector Co-occurrence Pattern (LMVCoP) has been proposed by concatenating the Local Mesh Co-occurrence Pattern (LMCoP) and the Local Vector Co-occurrence Pattern (LVCoP)...
August 31, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28861613/first-mortality-analysis-in-the-french-cohort-of-uranium-millers-f-millers-period-1968-2013
#18
Ségolène Bouet, Eric Samson, Iris Jovanovic, Dominique Laurier, Olivier Laurent
PURPOSE: Epidemiological studies in cohorts of uranium millers can be informative to improve knowledge of the health effects of uranium, but are very rare. The aim of this study was to analyze, for the first time, mortality in a French cohort of uranium millers. METHODS: The F-Millers cohort includes permanent contract workers employed at least 6 months at French uranium milling plants. Vital status and causes of death were obtained from national registries between 1968 and 2013, in order to perform comparisons with French national and local mortality rates by computing standardized mortality ratios (SMRs) with 95% confidence intervals (95% CI)...
August 31, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28860671/polyphasic-taxonomy-of-aspergillus-section-aspergillus-formerly-eurotium-and-its-occurrence-in-indoor-environments-and-food
#19
A J Chen, V Hubka, J C Frisvad, C M Visagie, J Houbraken, M Meijer, J Varga, R Demirel, Ž Jurjević, A Kubátová, F Sklenář, Y G Zhou, R A Samson
Aspergillus section Aspergillus (formerly the genus Eurotium) includes xerophilic species with uniseriate conidiophores, globose to subglobose vesicles, green conidia and yellow, thin walled eurotium-like ascomata with hyaline, lenticular ascospores. In the present study, a polyphasic approach using morphological characters, extrolites, physiological characters and phylogeny was applied to investigate the taxonomy of this section. Over 500 strains from various culture collections and new isolates obtained from indoor environments and a wide range of substrates all over the world were identified using calmodulin gene sequencing...
September 2017: Studies in Mycology
https://www.readbyqxmd.com/read/28855547/tylophorine-analogs-allosterically-regulates-heat-shock-cognate-protein-70-and-inhibits-hepatitis-c-virus-replication
#20
Ying Wang, Sangwon Lee, Ya Ha, Wing Lam, Shao-Ru Chen, Ginger E Dutschman, Elizabeth A Gullen, Susan P Grill, Yao Cheng, Alois Fürstner, Samson Francis, David C Baker, Xiaoming Yang, Kuo-Hsiung Lee, Yung-Chi Cheng
Tylophorine analogs have been shown to exhibit diverse activities against cancer, inflammation, arthritis, and lupus in vivo. In this study, we demonstrated that two tylophorine analogs, DCB-3503 and rac-cryptopleurine, exhibit potent inhibitory activity against hepatitis C virus (HCV) replication in genotype 1b Con 1 isolate. The inhibition of HCV replication is at least partially mediated through cellular heat shock cognate protein 70 (Hsc70). Hsc70 associates with the HCV replication complex by primarily binding to the poly U/UC motifs in HCV RNA...
August 30, 2017: Scientific Reports
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