Ninaad Lasrado, Ai-Ris Y Collier, Jessica Miller, Nicole P Hachmann, Jinyan Liu, Trisha Anand, Esther A Bondzie, Jana L Fisher, Camille R Mazurek, Robert C Patio, Stefanie L Rodrigues, Marjorie Rowe, Nehalee Surve, Darren M Ty, Cindy Wu, Taras M Chicz, Xin Tong, Bette Korber, Ryan P McNamara, Dan H Barouch
Messenger RNA (mRNA) vaccines were highly effective against the ancestral SARS-CoV-2 strain, but the efficacy of bivalent mRNA boosters against XBB variants was substantially lower. Here, we show limited durability of neutralizing antibody (NAb) responses against XBB variants and isotype switching to immunoglobulin G4 (IgG4) responses following bivalent mRNA boosting. Bivalent mRNA boosting elicited modest XBB.1-, XBB.1.5-, and XBB.1.16-specific NAbs that waned rapidly within 3 months. In contrast, bivalent mRNA boosting induced more robust and sustained NAbs against the ancestral WA1/2020 strain, suggesting immune imprinting...
February 23, 2024: Science Advances