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REVIEW
Sheila A Doggrell
INTRODUCTION: Immunoglobulin A (IgA) nephropathy is a common immune-mediated kidney disease leading to high blood pressure and may progress to kidney failure. None of the present treatments are disease-modifying or prolong life. The levels of A Proliferation Inducing Ligand (APRIL) are raised in subjects with IgA nephropathy. Sibeprenlimab is a humanized IgG2 monoclonal antibody that binds to, and neutralizes, APRIL. AREAS COVERED: A phase 2 clinical trial of intravenous sibeprenlimab (VIS649) in IgA nephropathy: NCT04287985...
April 20, 2024: Expert Opinion on Biological Therapy
#2
JOURNAL ARTICLE
Yi Zhang, Zhangfan Fu, Haocheng Zhang, Ke Lin, Jieyu Song, Jingxin Guo, Qiran Zhang, Guanmin Yuan, Hongyu Wang, Mingxiang Fan, Yuanhan Zhao, Rui Sun, Tiannan Guo, Ning Jiang, Chao Qiu, Wenhong Zhang, Jingwen Ai
BACKGROUND: The understanding of dynamic plasma proteome features in hybrid immunity and breakthrough infection is limited. A deeper understanding of the immune differences between heterologous and homologous immunization could assist in the future establishment of vaccination strategies. METHODS: In this study, 40 participants who received a third dose of either a homologous BBIBP-CorV or a heterologous ZF2001 protein subunit vaccine following two doses of inactivated coronavirus disease 2019 vaccines and 12 patients with BA...
April 17, 2024: Molecular & Cellular Proteomics: MCP
#3
JOURNAL ARTICLE
Son N Nguyen, Si-Hung Le, Daniil G Ivanov, Nikola Ivetic, Ishac Nazy, Igor A Kaltashov
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but dangerous side effect of adenoviral-vectored COVID-19 vaccines. VITT had been linked to production of autoantibodies recognizing platelet factor 4 (PF4). Here, we characterize anti-PF4 antibodies obtained from a VITT patient's blood. Intact mass measurements indicate that a significant fraction of these antibodies represent a limited number of clones. MS analysis of large antibody fragments (the light chain and the Fc/2 and Fd fragments of the heavy chain) confirms the monoclonal nature of this component of the anti-PF4 antibodies repertoire and reveals the presence of a mature complex biantennary N -glycan within the Fd segment...
April 12, 2024: Analytical Chemistry
#4
JOURNAL ARTICLE
R von Kiedrowski, T Hinz, G Mauer, A Schwinn, A Timmel, H J Hutt, M Augustin
BACKGROUND: Brodalumab, a fully human monoclonal immunoglobulin IgG2 antibody that binds the human interleukin 17 receptor subunit A, is available for the treatment of moderate-to-severe plaque psoriasis in Europe since September 2017, but so far there are only a few studies on its use in real-world conditions. OBJECTIVES: To assess the management of moderate-to-severe psoriasis with brodalumab 210 mg in daily practice after 12 and 52 weeks (W). In addition, patient profiles and treatment pathways are described...
April 4, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#5
JOURNAL ARTICLE
Yan Qin, Yuhan Jia, Congcong Liang, Rui Fu, Zhaojun Liang, Yanlin Wang, Min Feng, Chong Gao, Jing Luo
BACKGROUND: Detection of IgG subclasses (IgGSc) is vital for the diagnosis and management of disease, especially IgG4-related diseases (IgG4-RD). This study aimed to evaluate the performances of the chemiluminescent immunoassay (CLIA) for detecting IgGSc and diagnosing IgG4-RD by IgGSc. METHODS: A total of 40 individuals with IgG4-RD, 40 with primary Sjogren's syndrome (pSS), and 40 healthy controls (HCs) were enrolled. Serum samples were collected for the simultaneous detection of IgG1, IgG2, IgG3, and IgG4 by the Siemens immunonephelometric assay and the CLIA...
April 2, 2024: Journal of Clinical Laboratory Analysis
#6
JOURNAL ARTICLE
Yiqin Cai, Guihu Yin, Xiangyu Huang, Jianing Hu, Zichen Gao, Xinyu Guo, Yawei Qiu, Haifeng Sun, Xiuli Feng
Avian influenza (AI) caused by H9N2 subtype avian influenza virus (AIV) poses a serious threat to poultry farming and public health due to the transmissibility and pathogenicity. The PB2 protein is a major component of the viral RNA polymerase complex (vRNP). It is of great significance for identifying the antigenic determinants of PB2 protein to explore the function of PB2 protein. In this study, PB2 sequence of H9N2 subtype AIV from 1090 to 1689 bp was cloned and expressed in the prokaryotic expression pET-28a vector...
April 2, 2024: Avian Pathology: Journal of the W.V.P.A
#7
JOURNAL ARTICLE
Zhuo Li, Na Zhang, Zewen Dong, Xin Wang, Jian Zhou, Juan Gao, Yunyun Yang, Jing Li, Feng Guan, Yue Zhou, Zengqi Tan
BACKGROUND: Hepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a substantial challenge to global healthcare systems. In China, the primary risk factor for HCC is the hepatitis B virus (HBV). Aberrant serum glycoconjugate levels have long been linked to the progression of HBV-associated HCC (HBV-HCC). Nevertheless, few study systematically explored the dysregulation of glycoconjugates in the progression of HBV-associated HCC and their potency as the diagnostic and prognostic biomarker...
April 1, 2024: Cell Communication and Signaling: CCS
#8
REVIEW
Maurizio Bruschi, Andrea Angeletti, Marco Prunotto, Pier Luigi Meroni, Gian Marco Ghiggeri, Gabriella Moroni, Renato Alberto Sinico, Franco Franceschini, Micaela Fredi, Augusto Vaglio, Andrea Cavalli, Leonardo Scapozza, Jigar J Patel, John C Tan, Ken C Lo, Lorenzo Cavagna, Andrea Petretto, Federico Pratesi, Paola Migliorini, Francesco Locatelli, Giulia Pazzola, Giampaola Pesce, Domenico Giannese, Angelo Manfredi, Giuseppe A Ramirez, Pasquale Esposito, Giuseppe Murdaca, Simone Negrini, Federica Bui, Barbara Trezzi, Giacomo Emmi, Ilaria Cavazzana, Valentina Binda, Paride Fenaroli, Isabella Pisan, Carlomaurizio Montecucco, Domenico Santoro, Francesco Scolari, Federica Mescia, Stefano Volpi, Marta Mosca, Angela Tincani, Angelo Ravelli, Corrado Murtas, Giovanni Candiano, Gianluca Caridi, Edoardo La Porta, Enrico Verrina
Deposition of autoantibodies in glomeruli is a key factor in the development of lupus nephritis (LN). For a long time, anti-dsDNA and anti-C1q antibodies were thought to be the main cause of the kidney damage. However, recent studies have shown that the list of autoantibidies that have renal tropism and deposit in the kidney in LN is increasing and the link between anti-dsDNA and renal pathology is weak due to potential confounders. Aspecific bindings of dsDNA with cationic antibodies and of anti-dsDNA with several renal antigens such as actinin, laminin, entactin, and annexinA2 raised doubts about the specific target of these antibodies in the kidney...
March 27, 2024: Autoimmunity Reviews
#9
JOURNAL ARTICLE
Francisco Javier Turrubiates-Hernández, Samuel García-Arellano, Laura Elena Herrera-Jiménez, Guillermo González-Estevez, Fabiola Márquez-Sandoval, Diana Lourdes Padilla-Bórquez, Hazael Ramiro Ceja-Gálvez, Natali Vega-Magaña, Ferdinando Nicoletti, Guillermina Muñoz-Ríos, José Francisco Muñoz-Valle
Background: Respiratory tract infections remain among the leading causes of mortality worldwide. The COVID-19 pandemic has highlighted the importance of mucosal immunity in defending against infectious agents. Vitamin A is known to influence the production of secretory immunoglobulin A (SIgA) predominantly in the gut, where it is a critical component of the first line of defense on mucosal surfaces. Methods: This cross-sectional study, conducted 14 days post-positive COVID-19 diagnosis, aimed to determine the relationship between the nutritional status of vitamin A and SIgA levels in COVID-19 outpatients...
March 7, 2024: Journal of Clinical Medicine
#10
JOURNAL ARTICLE
Eulhae Ga, Jung-Ah Kang, Jaehyun Hwang, Suyun Moon, Jaeseok Choi, Eunseo Bae, Hyein Seol, Yubin Mun, Daesub Song, Dae Gwin Jeong, Woonsung Na
The various strains of influenza virus cause respiratory symptoms in humans every year and annual vaccinations are recommended. Due to its RNA-type genes and segmented state, it belongs to a virus that mutates frequently with antigenic drift and shift, giving rise to various strains. Each year, the World Health Organization identifies the epidemic strains and operates a global surveillance system to suggest the viral composition for the influenza vaccine. Influenza viruses, which have multiple viral strains, are produced in the format of multivalent vaccine...
March 30, 2024: Heliyon
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JOURNAL ARTICLE
Huong D Nguyen, Fabienne Jouen, Benoit Déchelotte, Nadège Cordel, Cyril Gitiaux, Christine Bodemer, Pierre Quatier, Alexandre Belot, Kathryn O'Brien, Dario Cancemi, Isabelle Melki, Nicole Fabien, Sarah Tansley, Olivier Boyer, Lucy R Wedderburn, Brigitte Bader-Meunier
No abstract text is available yet for this article.
March 18, 2024: Rheumatology
#12
JOURNAL ARTICLE
Natasha Rodrigues de Oliveira, Mara Andrade Colares Maia, Francisco Denis Souza Santos, Amilton Clair Pinto Seixas Neto, Thaís Larré Oliveira Bohn, Odir Antônio Dellagostin
Whole-cell inactivated vaccines (bacterins) are the only licensed vaccines available for leptospirosis prevention and control, especially in domestic and farm animals. However, despite their widespread use, inconsistencies in their efficacy have been reported. Because immunity induced by bacterins is mainly mediated by antibodies against leptospiral lipopolysaccharides, the involvement of cellular responses is not well-known. The aim of this study was to investigate the efficacy and characterize the humoral and cellular immune responses induced by whole-cell inactivated leptospirosis bacterin formulations containing serovars Bratislava, Canicola, Copenhageni, Grippotyphosa, Hardjoprajitno, and Pomona...
March 12, 2024: Comparative Immunology, Microbiology and Infectious Diseases
#13
JOURNAL ARTICLE
Nesrin Ghanem-Zoubi, Mona Mustafa-Hellou, Maram Zahran, Liat Gazit, Raya Shalaginov, Halima Dabaja-Younis, Moran Szwarcwort
UNLABELLED: Serum polymerase chain reaction (PCR) for the detection of Coxiella burnetii DNA has been suggested for rapid Q fever diagnosis. We evaluated the role of PCR testing in serum in the diagnosis of acute Q fever in an endemic setting. We examined patients suspected of acute Q fever tested for C. burnetii -specific serum real-time PCR in a tertiary hospital between January 2019 toand December 2022. In the first half, PCR orders were consultation-based by infectious diseases specialists, while in the second half, they were guided by serology, positive IgM2, and negative IgG1 and IgG2, indicating early acute infection...
March 12, 2024: Journal of Clinical Microbiology
#14
JOURNAL ARTICLE
Ying Wang, Miriam Hils, Andrea Fischer, Florian Wölbing, Tilo Biedermann, Angelika Schnieke, Konrad Fischer
The prevalence of food allergy is rising and is estimated to approach 10%. Red meat allergy is the first known food allergy elicited by immunoglobulin E (IgE) antibodies recognizing a carbohydrate. Due to the loss of function of the alpha-1,3-galactosyltransferase ( GGTA1) gene in humans, the disaccharide galactose-α-1,3-galactose (α-Gal) cannot be synthesized and therefore became immunogenic. IgE sensitization is elicited through the skin by repetitive tick bites transmitting α-Gal. The underlying mechanisms regarding innate and adaptive immune cell activation, including the B-cell isotype switch to IgE, are poorly understood, requiring further research and physiologically relevant animal models...
2024: Frontiers in Immunology
#15
JOURNAL ARTICLE
Tarun Keswani, Nicole A LaHood, Orlee Marini-Rapoport, Bijoya Karmakar, Léna Andrieux, Brian Reese, Sunny L Sneed, Lars C Pedersen, Geoffrey A Mueller, Sarita U Patil
BACKGROUND: Clinical efficacy of oral immunotherapy (OIT) has been associated with the induction of blocking antibodies, particularly those capable of disrupting IgE-allergen interactions. Previously, we identified monoclonal antibodies (mAb) to Ara h 2 and structurally characterized their epitopes. OBJECTIVE: We investigated longitudinal changes during OIT in antibody binding to conformational epitopes and correlated the results with isotype and clinical efficacy...
March 7, 2024: Journal of Allergy and Clinical Immunology
#16
JOURNAL ARTICLE
Denis M Schewe, Fotini Vogiatzi, Ira A Münnich, Tobias Zeller, Roland Windisch, Christian Wichmann, Kristina Müller, Hilal Bhat, Elisa Felix, Dimitrios Mougiakakos, Heiko Bruns, Lennart Lenk, Thomas Valerius, Andreas Humpe, Matthias Peipp, Christian Kellner
CD19-directed immunotherapy has become a cornerstone in the therapy of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). CD19-directed cellular and antibody-based therapeutics have entered therapy of primary and relapsed disease and contributed to improved outcomes in relapsed disease and lower therapy toxicity. However, efficacy remains limited in many cases due to a lack of therapy response, short remission phases, or antigen escape. Here, BCP-ALL cell lines, patient-derived xenograft (PDX) samples, human macrophages, and an in vivo transplantation model in NOD...
February 2024: HemaSphere
#17
JOURNAL ARTICLE
Isabela Machado Serrano, Gilmar Ribeiro, Ronnei Silva Santos, Jaqueline Silva Cruz, Fernanda Cardoso Lanza, Emily Ferreira Dos Santos, Márcio Cerqueira de Almeida, Jorgana Fernanda de Souza Soares, Alejandro Ostermayer Luquetti, Paola Alejandra Fiorani Celedon, Nilson Ivo Tonin Zanchin, Fred Luciano Neves Santos, Mitermayer Galvão Dos Reis
Chagas disease (CD) is caused by the protozoan Trypanosoma cruzi, which leads to a spectrum of clinical presentations that range from asymptomatic to severe cardiac involvement. The host immune response plays a pivotal role in disease progression. Ig isotypes may contribute to disease pathogenesis. Investigating these components can provide insights into the immunopathogenic mechanisms underlying CD. This cross-sectional study aims to establish a correlation between the Ig profile of individuals infected with T...
February 27, 2024: American Journal of Tropical Medicine and Hygiene
#18
JOURNAL ARTICLE
Ninaad Lasrado, Ai-Ris Y Collier, Jessica Miller, Nicole P Hachmann, Jinyan Liu, Trisha Anand, Esther A Bondzie, Jana L Fisher, Camille R Mazurek, Robert C Patio, Stefanie L Rodrigues, Marjorie Rowe, Nehalee Surve, Darren M Ty, Cindy Wu, Taras M Chicz, Xin Tong, Bette Korber, Ryan P McNamara, Dan H Barouch
Messenger RNA (mRNA) vaccines were highly effective against the ancestral SARS-CoV-2 strain, but the efficacy of bivalent mRNA boosters against XBB variants was substantially lower. Here, we show limited durability of neutralizing antibody (NAb) responses against XBB variants and isotype switching to immunoglobulin G4 (IgG4) responses following bivalent mRNA boosting. Bivalent mRNA boosting elicited modest XBB.1-, XBB.1.5-, and XBB.1.16-specific NAbs that waned rapidly within 3 months. In contrast, bivalent mRNA boosting induced more robust and sustained NAbs against the ancestral WA1/2020 strain, suggesting immune imprinting...
February 23, 2024: Science Advances
#19
JOURNAL ARTICLE
Rodrigo T Camacho-Pacheco, Jessica Hernández-Pineda, Yesenia Brito-Pérez, Noemi Plazola-Camacho, Irma A Coronado-Zarco, Gabriela Arreola-Ramírez, Mextli Y Bermejo-Haro, M Angel Najera-Hernández, Gabriela González-Pérez, Alma Herrera-Salazar, Andrea Olmos-Ortiz, Diana Soriano-Becerril, Claudia Sandoval-Montes, Ricardo Figueroa-Damian, Sandra Rodríguez-Martínez, Ismael Mancilla-Herrera
Over the last 20 years, the incidence of vertical HIV transmission has decreased from 25%-42% to less than 1%. Although there are no signs of infection, the health of HIV-exposed uninfected (HEU) infants is notoriously affected during the first months of life, with opportunistic infections being the most common disease. Some studies have reported effects on the vertical transfer of antibodies, but little is known about the subclass distribution of these antibodies. We proposed to evaluate the total IgG concentration and its subclasses in HIV+ mothers and HEU pairs and to determine which maternal factors condition their levels...
2024: Journal of Immunology Research
#20
JOURNAL ARTICLE
Jinfu Peng, Jie Huang, Hongyi Tan, Yun Kuang, Guoping Yang, Zhijun Huang
Monoclonal antibody drugs targeting proprotein convertase kwashiorkor type 9 (PCSK9) have recently demonstrated remarkable success in lipid-lowering therapies. Specifically, antibodies derived from immunoglobulin G1 (IgG1, alirocumab) and IgG2 (evolocumab) have been successfully utilized for this purpose. Recently, a novel recombinant fully human anti-PCSK9 monoclonal antibody, originally derived from IgG4 and designated as SAL003, was developed. This study aimed to explore the pharmacokinetics, efficacy, and safety of SAL003 in both single and multiple administrations...
February 9, 2024: ACS Pharmacology & Translational Science
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