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https://www.readbyqxmd.com/read/27904866/sj%C3%A3-gren-syndrome-related-membranous-glomerulonephritis-progressing-to-membranoproliferative-glomerulonephritis
#1
Junko Yabuuchi, Tatsuya Suwabe, Toshiharu Ueno, Junichi Hoshino, Akinari Sekine, Noriko Hayami, Masahiko Oguro, Kyohei Kunisawa, Masahiro Kawada, Masayuki Yamanouchi, Keiichi Sumida, Hiroki Mizuno, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
We report a case of glomerulopathy in a 36-year-old Japanese woman with primary Sjögren syndrome (pSS). The first renal biopsy suggested membranous glomerulonephritis. However, repeat biopsy was performed after 16 years because of increased proteinuria, revealing membranoproliferative glomerulonephritis with mesangial deposits, subendothelial deposits, and subepithelial deposits. Immunofluorescent studies showed predominant deposition of IgG2 and IgG4. This patient was positive for antinuclear antibody and anti-SS-A antibody...
September 2016: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/27898728/relationships-between-mucosal-antibodies-non-typeable-haemophilus-influenzae-nthi-infection-and-airway-inflammation-in-copd
#2
Karl J Staples, Stephen Taylor, Steve Thomas, Stephanie Leung, Karen Cox, Thierry G Pascal, Kristoffer Ostridge, Lindsay Welch, Andrew C Tuck, Stuart C Clarke, Andrew Gorringe, Tom M A Wilkinson
Non-typeable Haemophilus influenzae (NTHi) is a key pathogen in COPD, being associated with airway inflammation and risk of exacerbation. Why some patients are susceptible to colonisation is not understood. We hypothesised that this susceptibility may be due to a deficiency in mucosal humoral immunity. The aim of our study (NCT01701869) was to quantify the amount and specificity of antibodies against NTHi in the lungs and the associated risk of infection and inflammation in health and COPD. Phlebotomy, sputum induction and bronchoscopy were performed on 24 mild-to-moderate COPD patients and 8 age and smoking-matched controls...
2016: PloS One
https://www.readbyqxmd.com/read/27894314/self-assembly-of-hexahistidine-tagged-tobacco-etch-virus-capsid-protein-into-microfilaments-that-induce-igg2-specific-response-against-a-soluble-porcine-reproductive-and-respiratory-syndrome-virus-chimeric-protein
#3
Carlos Alberto Manuel-Cabrera, Alba Adriana Vallejo-Cardona, Eduardo Padilla-Camberos, Rodolfo Hernández-Gutiérrez, Sara Elisa Herrera-Rodríguez, Abel Gutiérrez-Ortega
BACKGROUND: Assembly of recombinant capsid proteins into virus-like particles (VLPs) still represents an interesting challenge in virus-based nanotechnologies. The structure of VLPs has gained importance for the development and design of new adjuvants and antigen carriers. The potential of Tobacco etch virus capsid protein (TEV CP) as adjuvant has not been evaluated to date. FINDINGS: Two constructs for TEV CP expression in Escherichia coli were generated: a wild-type version (TEV-CP) and a C-terminal hexahistidine (His)-tagged version (His-TEV-CP)...
November 29, 2016: Virology Journal
https://www.readbyqxmd.com/read/27876645/diagnostic-accuracy-of-rklo8-versus-rk26-elisas-for-screening-of-canine-visceral-leishmaniasis
#4
Lily P Martínez Abad, Caroline S Almeida, Ana Márcia M Mattos, Ana Carolina P Mendonça, Márcio J M Alves, Aimara C Pinheiro, Renato Porrozzi, Elfadil Abass, Ulrich Steinhoff, Henrique C Teixeira
Canine visceral leishmaniasis (CVL) represents an important public health issue. Despite numerous diagnostic tests available, CVL diagnosis still needs to be improved to achieve a more accurate detection rate. Recently, rKLO8, a new antigenic protein of Sudanese Leishmania donovani, was studied for the first time in diagnosis of human visceral leishmaniasis (HVL) and showed good performance. The present study aimed to evaluate serum reactivity to rKL08 and the reference antigen rK26, and to compare both diagnostic proteins with the combined DPP(®) CVL rapid test and ELISA (EIE-Bio-Manguinhos) confirmatory test, which are both recommended for the diagnosis of CVL in Brazil...
November 19, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27867073/immune-status-assessment-in-adult-lung-transplant-candidates
#5
Diana A van Kessel, Thijs W Hoffman, Heleen van Velzen-Blad, Ed A van de Graaf, Jan C Grutters, Ger T Rijkers
BACKGROUND: Lung transplant recipients have an increased susceptibility to a variety of infections due to immunosuppressive therapy. Current guidelines recommend pneumococcal and other vaccinations, prior to lung transplantation to protect against post-transplant infections, but measurement of the antibody response to vaccination is not advised. Immune status investigation in lung transplant candidates, including the response to pneumococcal polysaccharide vaccination, has not been described...
November 17, 2016: Transplant Immunology
https://www.readbyqxmd.com/read/27864476/anti-hinge-antibodies-recognize-igg-subclass-and-protease-restricted-neoepitopes
#6
Willem J J Falkenburg, Dirkjan van Schaardenburg, Pleuni Ooijevaar-de Heer, Michel W P Tsang-A-Sjoe, Irene E M Bultink, Alexandre E Voskuyl, Arthur E H Bentlage, Gestur Vidarsson, Gertjan Wolbink, Theo Rispens
Anti-hinge Abs (AHAs) target neoepitopes exposed after proteolytic cleavage of IgG. In this study, we explored the diversity of protease- and IgG subclass-restricted AHAs and their potential as immunological markers in healthy donors (HDs) and patients with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). AHA reactivity against IgG-degrading enzyme of Streptococcus pyogenes (IdeS)- or pepsin-generated F(ab')2 fragments of all four human IgG subclasses was determined. AHA reactivity against one or more out of eight F(ab')2 targets was found in 68% (68 of 100) of HDs, 69% (68 of 99) of SLE patients, and 81% (79 of 97) of RA patients...
November 18, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27863543/reduced-humoral-immunity-and-atypical-cell-mediated-immunity-in-response-to-vaccination-in-cows-naturally-infected-with-bovine-leukemia-virus
#7
Meredith C Frie, Kelly R Sporer, Joseph C Wallace, Roger K Maes, Lorraine M Sordillo, Paul C Bartlett, Paul M Coussens
Bovine leukemia virus (BLV) is a retrovirus that is widely distributed across US dairy herds: over 83% of herds are BLV-infected and within-herd infection rates can approach 50%. BLV infection reduces both animal longevity and milk production and can interfere with normal immune health. With such a high prevalence of BLV infection in dairy herds, it is essential to understand the circumstances by which BLV negatively affects the immune system of infected cattle. To address this question, BLV- and BLV+ adult, lactating Holstein dairy cows were vaccinated with Bovi-Shield GOLD(®) FP(®) 5 L5 HB and their immune response to vaccination was measured over the course of 28days...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27862687/anti-factor-viii-antibodies-in-brothers-with-haemophilia-a-share-similar-characteristics
#8
J Kahle, A Orlowski, D Stichel, J F Healey, E T Parker, S M Donfield, J Astermark, E Berntorp, P Lollar, D Schwabe, C Königs
INTRODUCTION: The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) is currently the most serious complication for patients with haemophilia A undergoing FVIII replacement therapy. Several genetic factors have been acknowledged as risk factors for inhibitor development. AIM: To analyze the influence of genetic factors on the nature of the humoral immune response to FVIII in eight brother pairs with inhibitors. METHODS: The domain specificity of FVIII-specific IgG was analysed by antibody binding to FVIII fragments and homologue-scanning mutagenesis (HSM)...
November 8, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27862028/peripheral-cellular-and-humoral-responses-to-infestation-with-the-cattle-tick-rhipicephalus-microplus-in-santa-gertrudis-cattle
#9
Emily K Piper, Nicholas N Jonsson, Cedric Gondro, Megan E Vance, Alicja Lew-Tabor, Louise A Jackson
Resistance to cattle tick infestation in single-host ticks is primarily manifested against the larval stage and results in the immature tick failing to attach successfully and obtain a meal. The present study was conducted to identify immune responses that characterise the tick-resistant phenotype in cattle. Thirty-five tick-naïve Santa-Gertrudis heifers were used in this study, thirty of which were artificially infested for thirteen weeks with tick larvae while five animals remained at a tick-free quarantine property to serve as a control group...
November 12, 2016: Parasite Immunology
https://www.readbyqxmd.com/read/27859022/igg1-and-igg4-anti-ccp-associate-with-shared-epitope-whereas-igg2-anti-ccp-associates-with-smoking-in-patients-with-recent-onset-rheumatoid-arthritis-the-swedish-tira-project
#10
Klara Martinsson, Anders Johansson, Alf Kastbom, Thomas Skogh
Given the possible importance of anti-citrullinated peptide/protein antibodies (ACPA) for initiation and progression of rheumatoid arthritis (RA), extended knowledge about the different isotypes and subclasses are important. In the present study we analysed the IgG subclasses regarding reactivity against citrullinated peptides (anti-CCP) among 504 clinically well-characterized patients with recent-onset RA in relation to smoking habits, shared epitope (SE) status, and IgA and pan IgG anti-CCP antibodies. All patients, regardless of pan IgG anti-CCP status, were analysed for IgG1-4 CCP reactivity...
November 17, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27816241/immune-response-after-an-experimental-intramammary-challenge-with-killed-staphylococcus-aureus-in-cows-and-heifers-vaccinated-and-not-vaccinated-with-startvac-a-polyvalent-mastitis-vaccine
#11
S Piepers, A Prenafeta, J Verbeke, A De Visscher, Ricard March, S De Vliegher
An experimental trial was conducted to explore the effect of vaccination with a polyvalent vaccine against mastitis (Startvac) on the early immune response after experimental intramammary challenge with a heterologous killed Staphylococcus aureus strain. The effect of vaccination on milk production, clinical signs, quarter milk somatic cell count, milk polymorphonuclear neutrophilic leukocyte (PMN) concentration and viability, the concentration of antigen-specific antibodies [slime associated antigenic complex (SAAC) and J5] and their IgG1 and IgG2 subtypes in both serum and whey, and the antigen-specific IFN-γ, IL-4, and IL-17 production by blood lymphocytes after in vitro stimulation with S...
November 2, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27804292/analysis-of-pre-existing-igg-and-igm-antibodies-against-polyethylene-glycol-peg-in-the-general-population
#12
Qi Yang, Timothy M Jacobs, Justin D McCallen, Dominic T Moore, Justin T Huckaby, Jasmine Edelstein, Samuel K Lai
Circulating antibodies (Ab) that specifically bind polyethylene glycol (PEG), a biocompatible polymer routinely used in protein and nanoparticle therapeutics, have been associated with reduced efficacy of and/or adverse reactions to therapeutics modified with or containing PEG. Unlike most anti-drug antibodies that are induced following initial drug dosing, anti-PEG Ab can be found in treatment-naïve individuals. Unfortunately, the true prevalence, quantitative levels and Ab isotype of pre-existing anti-PEG Ab remain poorly understood...
November 2, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27799928/evaluation-of-the-antigen-experienced-b-cell-receptor-repertoire-in-healthy-children-and-adults
#13
Hanna IJspeert, Pauline A van Schouwenburg, David van Zessen, Ingrid Pico-Knijnenburg, Gertjan J Driessen, Andrew P Stubbs, Mirjam van der Burg
Upon antigen recognition via their B cell receptor (BR), B cells migrate to the germinal center where they undergo somatic hypermutation (SHM) to increase their affinity for the antigen, and class switch recombination (CSR) to change the effector function of the secreted antibodies. These steps are essential to create an antigen-experienced BR repertoire that efficiently protects the body against pathogens. At the same time, the BR repertoire should be selected to protect against responses to self-antigen or harmless antigens...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27798619/protective-neutralizing-influenza-antibody-response-in-the-absence-of-t-follicular-helper-cells
#14
Kosuke Miyauchi, Akiko Sugimoto-Ishige, Yasuyo Harada, Yu Adachi, Yoshiko Usami, Tomohiro Kaji, Kentaro Inoue, Hideki Hasegawa, Takashi Watanabe, Atsushi Hijikata, Satoshi Fukuyama, Tadashi Maemura, Mariko Okada-Hatakeyama, Osamu Ohara, Yoshihiro Kawaoka, Yoshimasa Takahashi, Toshitada Takemori, Masato Kubo
Virus infection induces the development of T follicular helper (TFH) and T helper 1 (TH1) cells. Although TFH cells are important in anti-viral humoral immunity, the contribution of TH1 cells to a protective antibody response remains unknown. We found that IgG2 antibodies predominated in the response to vaccination with inactivated influenza A virus (IAV) and were responsible for protective immunity to lethal challenge with pathogenic H5N1 and pandemic H1N1 IAV strains, even in mice that lacked TFH cells and germinal centers...
December 2016: Nature Immunology
https://www.readbyqxmd.com/read/27795302/identification-of-a-t-cell-epitope-that-is-globally-conserved-among-outer-membrane-proteins-omps-omp7-omp8-and-omp9-of-anaplasma-marginale-strains-and-with-omp7-from-the-a-marginale-subsp-centrale-vaccine-strain
#15
James R Deringer, Elkin G Forero-Becerra, Massaro W Ueti, Joshua E Turse, James E Futse, Susan M Noh, Guy H Palmer, Wendy C Brown
Within the protective outer membrane (OM) fraction of Anaplasma marginale, several vaccine candidates have emerged, including a family of OM proteins (OMPs) 7-9, which share sequence identity with each other and with the single protein OMP7 in the vaccine strain A. marginale subsp. centrale. A. marginale OMPs 7-9 are logical vaccine candidates because they are surface exposed, present in the OM immunogen and protective cross-linked OM proteins, recognized by immune serum IgG2 and T-cells in cattle immunized with OM, and recognized by immune serum IgG2 from cattle immunized with the A...
October 26, 2016: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/27790964/increased-igg-antibody-responses-to-excretory-secretory-antigens-in-neonates-born-from-mothers-infected-with-filarial-nematodes
#16
K G Achary, M S Bal, N N Mandal, A K Satapathy
The present investigation aimed to evaluate the extent to which maternal filarial infection influences IgG subclass immune responses in the cord blood of neonates. Prevalence of antigenaemia was detected using an Og4C3 assay. Filaria-specific IgG subclasses against excretory/secretory antigens were measured by ELISA. Transplacental transfer of circulating filarial antigen (CFA) was observed from 34.8% of CFA-positive mothers to their respective cord bloods. Filaria-specific IgG1, IgG2 and IgG4 responses were significantly higher among cord bloods of infected mothers compared to cord bloods of uninfected mothers...
October 28, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27789145/comparative-analysis-of-influenza-a-h3n2-virus-hemagglutinin-specific-igg-subclass-and-iga-responses-in-children-and-adults-after-influenza-vaccination
#17
Alessandro Manenti, Sarah M Tete, Kristin G-I Mohn, Åsne Jul-Larsen, Elena Gianchecchi, Emanuele Montomoli, Karl A Brokstad, Rebecca J Cox
Two different influenza vaccines are generally used in many countries; trivalent live attenuated influenza vaccine (LAIV3) and trivalent inactivated influenza vaccine (IIV3). Studies comparing the antibody response to IIV3 and LAIV3 commonly investigate the seroprotective response by hemagglutination-inhibition (HI) assay. However, there is limited data regarding comparative analysis of IgG subclass and IgA responses induced by LAIV3 and IIV3. Fifteen children <5years received 2 doses of LAIV3 while 14 children aged 10-17years received one dose...
October 24, 2016: Vaccine
https://www.readbyqxmd.com/read/27776522/inositol-1-4-5-trisphosphate-receptor-type-1-autoantibodies-in-paraneoplastic-and-non-paraneoplastic-peripheral-neuropathy
#18
Sven Jarius, Marius Ringelstein, Jürgen Haas, Irina I Serysheva, Lars Komorowski, Kai Fechner, Klaus-Peter Wandinger, Philipp Albrecht, Harald Hefter, Andreas Moser, Eva Neuen-Jacob, Hans-Peter Hartung, Brigitte Wildemann, Orhan Aktas
BACKGROUND: Recently, we described a novel autoantibody, anti-Sj/ITPR1-IgG, that targets the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in patients with cerebellar ataxia. However, ITPR1 is expressed not only by Purkinje cells but also in the anterior horn of the spinal cord, in the substantia gelatinosa and in the motor, sensory (including the dorsal root ganglia) and autonomic peripheral nervous system, suggesting that the clinical spectrum associated with autoimmunity to ITPR1 may be broader than initially thought...
October 24, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27765717/comparison-of-in%C3%A2-vivo-immunomodulatory-effects-of-5-hydroxymethylfurfural-and-5-5-oxydimethylenebis-2-furfural
#19
Ni Lin, Tiantian Liu, Lin Lin, Sheng Lin, Qingce Zang, Jiuming He, Zeper Abliz, Chao Li, Aiping Wang, Hongtao Jin
The standard of 5-Hydroxymethylfurfural (5-HMF) existed in dextrose injection as an inevitable by-product during high-temperature setrilization has been included in pharmacopoeias considering its hazardous effects on human health. We found that the concentrations of 5-HMF in some traditional Chinese medicine injections (TCMIs) far exceeded its limit in dextrose injection. Besides, we detected 5, 5'-Oxydimethylenebis (2-furfural) (OMBF) in those TCMIs containing high concentrations of 5-HMF. We investigated the in vivo immunomodulatory effects of 5-HMF and OMBF at three dose levels using the reporter antigen popliteal lymph node assay (RA-PLNA), which allows the straightforward examination and mechanistic study of immunotoxicity of low molecular weight compounds...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27756533/immunogencity-of-antigens-from-mycobacterium-tuberculosis-self-assembled-as-particulate-vaccines
#20
Patricia Rubio Reyes, Natalie A Parlane, D Neil Wedlock, Bernd H A Rehm
Traditional approaches to vaccine development have failed to identify better vaccines to replace or supplement BCG for the control of tuberculosis (TB). Subunit vaccines offer a safer and more reproducible alternative for the prevention of diseases. In this study, the immunogenicity of bacterially derived polyester beads displaying three different Rv antigens of Mycobacterium tuberculosis was evaluated. Polyester beads displaying the antigens Rv1626, Rv2032, Rv1789, respectively, were produced in an endotoxin-free Escherichia coli strain...
October 13, 2016: International Journal of Medical Microbiology: IJMM
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