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Septic arthritis

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https://www.readbyqxmd.com/read/29339199/neutralization-of-tnfr-1-and-tnfr-2-modulates-s-aureus-induced-septic-arthritis-by-regulating-the-levels-of-pro-inflammatory-and-anti-inflammatory-cytokines-during-the-progression-of-the-disease
#1
Sahin Sultana, Biswadev Bishayi
Staphylococcal septic arthritis remains a serious medical concern due to rapid and sustained production of inflammatory cytokines that leads to progressive and irreversible joint destruction with high mortality rate in patients despite adequate antibiotics treatment. TNF-α signalling via TNFR-1 contributes to arthritic destruction by aggravating inflammation. Impact of TNFR-2 signalling is not well established in this aspect. Hence the objective of our study was to evaluate the role of dual neutralization TNFR-1 and TNFR-2 in the pathogenesis of S...
January 12, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29329124/septic-arthritis-of-the-wrist
#2
John D Jennings, Asif M Ilyas
Septic arthritis of the wrist is an uncommon condition, but one that can result in substantial morbidity. Timely identification and treatment is critical to patient care. No serum laboratory values have been shown to consistently confirm wrist joint infection. Thus, diagnosis is made based mainly on a thorough patient history, physical examination, and joint aspiration. When infection is suspected, aspiration of the wrist should be performed to confirm the diagnosis. Broad-spectrum antibiotics and joint aspiration or surgery are required to manage the infection and prevent sequelae...
January 11, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29326375/group-b-streptococcus-septic-arthritis-of-the-hip-following-spontaneous-abortion
#3
Madeline Lyons, Elizabeth Zielinski, Jibanananda Satpathy
Group B streptococcus (GBS) infection of the hip in otherwise healthy adults is a rare entity that is previously only reported following peripartum gynaecological procedure and instrumentation. We report a case of infection of the hip with GBS following spontaneous abortion. Delay in identification of infection as the cause of pain ultimately leads to irreversible joint destruction. This case report will heighten the awareness of the first contact providers as well as orthopaedic surgeons to be more vigilant for possible septic complications associated with gynaecological procedures/complications and subsequent painful joints...
January 11, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29322903/difficult-to-treat-osteoarticulars-infections%C3%A2-focus-on-mycobacterial-and-fungal-infection
#4
J C Yombi, L Seyler, O Cornu, O Barbier, X Libouton, H Rodriguez-Villalobos, E Thienpont
Bone and joint infections are rare but often devastating. While bacteria are most commonly encountered organisms, mycobacteria and fungi are less frequent. Management of the latter is often more complex, especially in the presence of foreign material. We will increasingly be faced with mycobacterial and fungal bone infections, as medical conditions and newer therapeutics lead to more immunosuppression. In this article, we will review osteomyelitis, septic arthritis and peri-prosthetic joint infections related to mycobacteria and fungi...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29309715/host-factors-affect-the-outcome-of-arthroscopic-lavage-treatment-of-septic-arthritis-of-the-knee
#5
Taebyeong Kang, Jin Kyu Lee
The purpose of this study was to determine the prognostic factors related to the outcome of lavage surgery in patients with septic arthritis of the knee. A total of 55 patients with acute septic arthritis who underwent arthroscopic lavage were enrolled in the study. Host factors, including age, medical comorbidities, and medication use, were evaluated according to the Musculoskeletal Infection Society staging system, and patients were then stratified into 3 types: type A, no compromising factors; type B, 1 to 2 compromising factors; and type C, more than 2 compromising factors...
January 8, 2018: Orthopedics
https://www.readbyqxmd.com/read/29309293/orthopaedic-manifestations-of-sickle-cell-disease
#6
Kelly L Vanderhave, Crystal A Perkins, Brian Scannell, Brian K Brighton
Sickle cell disease (SCD) is an autosomal recessive disorder that results in hemolytic anemia related to abnormal hemoglobin and erythrocyte levels. SCD is characterized by vascular occlusive episodes, visceral sequestration, and aplastic or hemolytic crises. These crises most commonly occur in bone. The orthopaedic manifestations of SCD comprise much of the morbidity associated with this disorder. Osteonecrosis and osteomyelitis are among the most disabling and serious musculoskeletal complications in patients with SCD...
January 5, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29309200/risk-factors-for-infection-after-shoulder-arthroscopy-in-a-large-medicare-population
#7
Jourdan M Cancienne, Stephen F Brockmeier, Eric W Carson, Brian C Werner
BACKGROUND: Shoulder arthroscopy is well established as a highly effective and safe procedure for the treatment for several shoulder disorders and is associated with an exceedingly low risk of infectious complications. Few data exist regarding risk factors for infection after shoulder arthroscopy, as previous studies were not adequately powered to evaluate for infection. PURPOSE: To determine patient-related risk factors for infection after shoulder arthroscopy by using a large insurance database...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29305995/acute-septic-arthritis-of-the-knee-a-rare-case-report-of-infection-with-parvimonas-micra-after-an-intra-articular-corticosteroid-injection-for-osteoarthritis
#8
Assem A Sultan, William A Cantrell, Anton Khlopas, Connor Cole, Nicolas S Piuzzi, Nipun Sodhi, Peter Brooks, Michael A Mont
Acute bacterial mono-articular septic arthritis affects most commonly the lower extremity joints in adult population and most commonly caused by Staphylococcus aureus. Various risk factors determine susceptibility to infection including host immunity, medical co-morbidity and joint structural abnormality and other organisms may be involved. Parvimonas micra (P. micra) is among the rare organisms that may be associated with atypical septic arthritis and primarily affects the native knee joint. Only 3 case reports in the literature have reported on pyogenic pyogenic joint infection caused by this organism...
January 3, 2018: Anaerobe
https://www.readbyqxmd.com/read/29301169/primary-septic-arthritis-of-the-knee-due-to-mycobacterium-tuberculosis-in-a-previously-healthy-child
#9
Samuel Rosas, Daniel Rosas, Valentina Múnera Orozco, Manuela Parra Cardona, Chukwuweike Gwam, Simon Pedro Aristizabal
Pediatric septic arthritis can be a devastating disease. Often, the diagnosis can be challenging as autoimmune and infectious causes may present in a similar fashion. Thus, we present the case of a five-year-old male patient, from the Pacific coast of Colombia, with chronic morning knee pain and stiffness thought to be caused by an autoimmune disease. He presented with a mild effusion of the left knee, a flexed posture, and limited extension to 25°. Inflammatory markers demonstrated an infectious pattern. Autoimmune markers were negative...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29296168/glenohumeral-joint-sepsis-after-joint-injection-through-a-new-tattoo
#10
Richard Becker, Sean Haight
We report a case of Propionibacterium acnes septic arthritis of a shoulder following two joint access procedures. Methodical investigation of these two procedures was performed using the Joint Commission root cause analysis matrix, which involved examination of protocols, interviews with technologists and physicians, and inspection of the procedure rooms and equipment. No procedural error or other causal factor for infection was found other than the injection through a five day-old tattoo during the first procedure...
November 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29290546/characteristics-of-claims-in-the-management-of-septic-arthritis-in-japan-retrospective-analyses-of-judicial-precedents-and-closed-claims
#11
Yasuhiro Otaki, Makiko Ishida DaSilva, Yuichi Saito, Yasuaki Oyama, Giichiro Oiso, Tomohiko Yoshida, Masakazu Fukuhara, Mitsuru Moriyama
BACKGROUND: Septic arthritis (SA) cases can result in claims or litigation because of poor prognosis even if it is unavoidable. Although these claims or litigation are useful for understanding causes and background factors of medical errors, the characteristics of malpractice claims associated with SA remain undetermined in Japan. This study aimed to increase our understanding of malpractice claims in the clinical management of SA. METHODS: We analyzed 6 civil precedents and 16 closed claims of SA from 8530 malpractice claims processed between July 2004 and June 2014 by the Tokyo office of Sompo Japan Nipponkoa Insurance, Incorporated...
December 28, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29290233/antibiotic-therapy-of-bone-and-joint-infections-in-children-proposals-of-the-french-pediatric-infectious-disease-group
#12
M Lorrot, Y Gillet, C Gras Le Guen, E Launay, R Cohen, E Grimprel
Acute hematogenous bone and joint infections (osteomyelitis, septic arthritis, osteoarthritis, and spondylodiscitis) affect more frequently children younger than 5 years of age. Early diagnosis and prompt treatment are needed to limit the risk of complications. Children with suspected bone and joint infections (BJI) should be hospitalized at the beginning of treatment. Surgical drainage is indicated in patients with septic arthritis and in those with periosteal abscess. Staphylococcus aureus is involved in BJIs in children at all ages; Kingella kingae is a very common causative pathogen in children under 4 years of age...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29289987/pelvic-pyomyositis-in-children-changing-trends-in-occurrence-and-management
#13
Manish Kiran, Saffwan Mohamed, Ashley Newton, Harvey George, Neeraj Garg, Colin Bruce
AIMS: We present the largest series of paediatric pelvic pyomyositis from a temperate country, analyse the factors influencing long term prognosis and suggest a diagnostic protocol. MATERIALS AND METHOD: We included 41 patients diagnosed with primary paediatric pelvic pyomyositis between 1998 and 2016, in this study with a mean age of 7.5 years. Demographic, clinical, radiological and follow-up data were reviewed. Statistical analysis was performed to analyse the influence of early diagnosis and treatment on the final outcome...
December 30, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29286020/a-case-of-candida-septic-arthritis-with-rice-body-formation-in-a-2-month-old-infant
#14
Francesco d'Aleo, Roberta Bonanno, Angelina Midiri, Giuseppe Mancuso, Stefania Cordaro, Amiel Warm, Elisa Verduci, Concetta Beninati, Carmelo Biondo
We present a case of rice body formation in the left knee joint of a 2-month-old infant affected by Candida albicans septic arthritis which has never been reported before. Rice body formation has been described in association with rheumatoid or tuberculous arthritis and is very rare in Candida arthritis. After three weeks of therapy with amphotericin B administered intravenously, the infant recovered fully from infection. Septic arthritis is a serious cause of morbidity and for proper evaluation and treatment fungal septic arthritis should be included in the differential diagnosis...
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29274860/primary-pyomyositis-in-children
#15
M M Elzohairy
BACKGROUND: Pyomyositis PM is defined as a primary pyogenic infection of the striated skeletal muscle; although it has many dystrophic musculoskeletal complications, it is always misdiagnosed by many orthopedic surgeons. HYPOTHESIS: PM is rare in temperate climates and usually considered to be a tropical disease, until recent times, after globalization, it is possible to occur in the subtropical climate as in our country. MATERIAL AND METHODS: In the present series, the results of 15 children patients with primary pyomyositis have been reviewed...
December 21, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29250041/stenotrophomonas-maltophilia-as-an-emerging-ubiquitous-pathogen-looking-beyond-contemporary-antibiotic-therapy
#16
REVIEW
Anthony A Adegoke, Thor A Stenström, Anthony I Okoh
Stenotrophomonas maltophilia is a commensal and an emerging pathogen earlier noted in broad-spectrum life threatening infections among the vulnerable, but more recently as a pathogen in immunocompetent individuals. The bacteria are consistently being implicated in necrotizing otitis, cutaneous infections including soft tissue infection and keratitis, endocarditis, meningitis, acute respiratory tract infection (RTI), bacteraemia (with/without hematological malignancies), tropical pyomyositis, cystic fibrosis, septic arthritis, among others...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29249550/sternoclavicular-joint-infection-presenting-as-nonspecific-chest-pain
#17
Scott A McAninch, Clinton Smithson, Andrew L Juergens, Jason N Collins, Amrita Nanda
BACKGROUND: Sternoclavicular joint infection (SJI), to include septic arthritis (SA), is a rare cause of chest pain and is often found in patients with significant risk factors and sources for SA. Most acute care laboratory results lack significant sensitivity to rule out SA. Radiographic findings in common acute care imaging often does not reveal findings of SA and osteomyelitis in the acute phase of the infection. CASE REPORT: We present a patient without significant risk factors for SA, who initially presented with 3 days of pain to the left chest, left neck and shoulder...
December 14, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29244707/complicated-total-knee-arthroplasty-in-a-patient-with-klippel-trenaunay-weber-syndrome-a-case-report
#18
Elias G Joseph, Emily P Ernest, Matthew J Dietz
CASE: A 66-year-old Caucasian man with Klippel-Trenaunay-Weber syndrome (KTWS) presented with chronic changes related to the KTWS, along with worsening pain and motion associated with residual damage from an episode of spontaneous septic arthritis that occurred 1 year prior. He underwent total joint arthroplasty with a rotating hinged knee implant. CONCLUSION: Arthroplasty is a treatment option for patients with KTWS; however, there are risks that must be considered...
July 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29241843/quantifying-the-effect-of-diabetes-on-surgical-hand-and-forearm-infections
#19
Ketan Sharma, Deng Pan, James Friedman, Jenny L Yu, Aaron Mull, Amy M Moore
PURPOSE: Diabetes has long been established as a risk factor for hand and forearm infections. The purpose of this study was to review the effect of glycemic factors on outcomes among diabetic patients with surgical upper-extremity infections. We hypothesized that diabetic inpatients may benefit from stronger peri-infection glycemic control. METHODS: A prospective cohort study enrolled diabetic and nondiabetic surgical hand and forearm infections over 3 years. Glycemic factors included baseline glycosylated hemoglobin, blood glucose (BG) at presentation, and inpatient BG...
December 11, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29240741/a-retrospective-audit-of-the-characteristics-and-treatment-outcomes-in-patients-with-diabetes-related-charcot-neuropathic-osteoarthropathy
#20
Joanne Dixon, Joshua Coulter, Michele Garrett, Rick Cutfield
AIMS: To review the characteristics, management and outcomes one year after diagnosis in patients with diabetes related charcot neuropathic osteoarthropathy (CN) treated at the Diabetes Podiatry service, Waitemata District Health Board (WDHB) between 2000-2014. METHODS: Patients with diabetes and recorded diagnosis of CN were identified from the podiatry service records. Clinical details were retrospectively obtained from WDHB databases and patient medical records...
December 15, 2017: New Zealand Medical Journal
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