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Hepatocellular adenoma

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https://www.readbyqxmd.com/read/27914986/identification-of-epigenetically-downregulated-tmem70-and-ube2e2-in-rat-liver-after-28-day-treatment-with-hepatocarcinogenic-thioacetamide-showing-gene-product-downregulation-in-hepatocellular-preneoplastic-and-neoplastic-lesions-produced-by-tumor-promotion
#1
Sayaka Mizukami, Atsunori Yafune, Yousuke Watanabe, Kota Nakajima, Meilan Jin, Toshinori Yoshida, Makoto Shibutani
The present study identified genes showing promoter region hypermethylation by CpG island microarrays in the liver of rats treated with hepatocarcinogen thioacetamide (TAA) for 28 days. Among 47 hypermethylated genes, Hist1h2aa, Tmem70, Ube2e2, and Slk were confirmed to show hypermethylation by methylation-specific polymerase chain reaction (PCR) and pyrosequencing analyses as well as downregulation of transcript levels by real-time reverse transcription-PCR analysis in the livers of rats treated with TAA. All gene products of the 4 selected genes showed decreased immunoreactivity forming negative liver cell foci in a subpopulation of glutathione S-transferase placental form (GST-P)(+) foci in TAA-promoted rat livers in a two-stage hepatocarcinogenesis model...
November 30, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27903597/impact-of-organic-cation-transporters-oct-slc22a-on-differential-diagnosis-of-intrahepatic-lesions
#2
Michele Visentin, Belle V van Rosmalen, Christian Hiller, Matthanja Bieze, Lia Hofstetter, Joanne Verheij, Gerd A Kullak-Ublick, Hermann Koepsell, Saffire Sks Phoa, Ikumi Tamai, Roelof J Bennink, Thomas M van Gulik, Bruno Stieger
Positron emission tomography (PET) using the cationic compound [(18)F]fluoromethylcholine (FCH) enhances the sensitivity for non-invasive classification of hepatic tumours due to peculiar patterns of accumulation. The underlying transporters are not known. We aim to identify the carriers mediating uptake of FCH in liver and to correlate their expression pattern with PET intrahepatic signal distribution to clarify the role of membrane transporters in FCH accumulation. FCH transport was characterized in cells overexpressing organic cation transporters (OCTs)...
November 30, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27900094/malignant-transformation-of-hepatocellular-adenoma-with-bone-marrow-metaplasia-arising-in-glycogen-storage-disease-type-i-a-case-report
#3
Tomohiro Iguchi, Motoyuki Yamagata, Takashi Sonoda, Kimihiko Yanagita, Tetsuhiro Fukahori, Eiji Tsujita, Shinichi Aishima, Yoshinao Oda, Yoshihiko Maehara
Malignant transformation of hepatocellular adenoma (HA) is relatively rare and has been reported to be associated with dysregulation of the β-catenin pathway. The presence of bone marrow metaplasia in HA is an uncommon histological characteristic. The current report presents the case of a 46-year-old woman with glycogen storage disease type I (von Gierke's disease) who underwent resection of hepatocellular carcinoma (HCC) arising in a HA with associated bone marrow metaplasia producing three series of hematopoietic cells...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27861172/liver-subcapsular-hematoma-a-rare-cause-of-sudden-unexpected-death
#4
Dorra Oualha, Abir Aissaoui, Meriam Belhaj, Mohamed Amin Mesrati, Adnene Moussa, Nidhal Haj Salem, Abdelfateh Zakhama, Ali Chadly
The spontaneous subcapsular hematoma of the liver is very rare. There are only a few reported cases in the literature.Most reported cases of liver hematoma often occur during pregnancy as part of the hemolysis, elevated liver enzymes, and low platelet count syndrome. The other causes may be due to amylosis, rupture of hepatocellular carcinoma, adenoma, focal nodular hyperplasia, hemorrhagic cyst, or hemopathy. Idiopathic spontaneous subscapular hematoma is a rare and often fatal condition.We report a case of a 43-year-old woman having Steinert disease who died because of a fatal spontaneous liver hemorrhage occurring without any traumatism...
November 17, 2016: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/27859748/use-of-serum-micrornas-as-biomarker-for-hepatobiliary-diseases-in-dogs
#5
K Dirksen, T Verzijl, G C Grinwis, R P Favier, L C Penning, I A Burgener, L J van der Laan, H Fieten, B Spee
BACKGROUND: Current biochemical indicators cannot discriminate between parenchymal, biliary, vascular, and neoplastic hepatobiliary diseases. MicroRNAs are promising new biomarkers for hepatobiliary disease in humans and dogs. OBJECTIVE: To measure serum concentrations of an established group of microRNAs in dogs and to investigate their concentrations in various types of hepatobiliary diseases. ANIMALS: Forty-six client-owned dogs with an established diagnosis of hepatobiliary disease and stored serum samples and eleven client-owned healthy control Labrador Retrievers...
November 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27803743/hepatocellular-adenoma-when-and-how-to-treat-update-of-current-evidence
#6
REVIEW
Maarten G Thomeer, Mirelle Broker, Joanne Verheij, Michael Doukas, Turkan Terkivatan, Diederick Bijdevaate, Robert A De Man, Adriaan Moelker, Jan N IJzermans
Hepatocellular adenoma (HCA) is a rare, benign liver tumor. Discovery of this tumor is usually as an incidental finding, correlated with the use of oral contraceptives, or pregnancy. Treatment options have focused on conservative management for the straightforward, smaller lesions (<5 cm), with resection preferred for larger lesions (>5 cm) that pose a greater risk of hemorrhage or malignant progression. In recent years, a new molecular subclassification of HCA has been proposed, associated with characteristic morphological features and loss or increased expression of immunohistochemical markers...
November 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27781382/hepatocellular-adenoma-among-adult-survivors-of-childhood-and-young-adult-cancer
#7
Emily S Tonorezos, Dana Barnea, Ghassan K Abou-Alfa, Jacqueline Bromberg, Michael D'Angelica, Charles A Sklar, Jinru Shia, Kevin C Oeffinger
Hepatocellular adenoma (HCA) is a rare benign epithelial neoplasm with potential for hemorrhage, rupture, or malignant transformation. Reported annual incidence of HCA is approximately 1/1,000,000. We identified 12 cases of HCA among adults with a history of childhood or young adult cancer. The most common cancer diagnosis was leukemia (N = 4). Five had undergone allogeneic hematopoietic stem cell transplant with total body irradiation. All 11 females had prior estrogen therapy; the male case was hypogonadal...
October 26, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27780309/incidental-inflammatory-adenoma-with-%C3%AE-catenin-activation-in-the-setting-of-paediatric-nash
#8
S Oliveira, A K Samba, A J Towbin, A Gupta, J I Geller, J D Nathan, R Kohli
: Hepatocellular adenomas (HCA) are benign tumours with potential for malignant transformation with no recommendations regarding management in the paediatric population. We report a case of an inflammatory adenoma with β-catenin activated pathway in an obese, paediatric patient with nonalcoholic steatohepatitis (NASH). CASE REPORT: An 11-year-old female presented with a microlobulated liver lesion measuring >5 cm in magnetic resonance imaging (MRI) with inflammatory adenoma with β-catenin activated pathology arising in a background of NASH, nonalcoholic fatty liver disease (NAFLD) activity score 5/8...
October 25, 2016: Pediatric Obesity
https://www.readbyqxmd.com/read/27740898/benign-hepatocellular-nodules-hepatobiliary-phase-of-gadoxetic-acid-enhanced-mr-imaging-based-on-molecular-background
#9
Norihide Yoneda, Osamu Matsui, Azusa Kitao, Kazuto Kozaka, Satoshi Kobayashi, Motoko Sasaki, Kotaro Yoshida, Dai Inoue, Tetsuya Minami, Toshifumi Gabata
Gadoxetic acid is a contrast agent for magnetic resonance (MR) imaging with hepatocyte-specific properties and is becoming increasingly important in detection and characterization of hepatocellular carcinoma and benign hepatocellular nodules, including focal nodular hyperplasia (FNH), nodular regenerative hyperplasia (NRH), hepatocellular adenoma (HCA), and dysplastic nodule. In these hepatocellular nodules, a positive correlation between the grade of membranous uptake transporter organic anion-transporting polypeptide (OATP) 1B3 expression and signal intensity in the hepatobiliary (HB) phase has been verified...
October 14, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27704147/impact-of-hepatobiliary-phase-liver-mri-versus-contrast-enhanced-ultrasound-after-an-inconclusive-extracellular-gadolinium-based-contrast-enhanced-mri-for-the-diagnosis-of-benign-hepatocellular-tumors
#10
Lambros Tselikas, Frederic Pigneur, Marion Roux, Laurence Baranes, Charlotte Costentin, Vincent Roche, Julien Calderaro, Edouard Herin, Alexis Laurent, Elie Zafrani, Daniel Azoulay, Ariane Mallat, Alain Rahmouni, Alain Luciani
PURPOSE: To compare the added values of hepatobiliary phase (HBP) MRI and contrast-enhanced ultrasound (CEUS) in addition to inconclusive extracellular gadolinium-based contrast-enhanced MRI (CE-MRI) to characterize benign hepatocellular tumors (BHT). METHODS: Eighty-three BHT-46 focal nodular hyperplasia (FNH) and 37 hepatocellular adenomas (HCA)-with inconclusive CE-MRI in 54 patients (43 women and 11 men, mean age 42 years old ± 14.8) were retrospectively analyzed...
October 4, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27692588/use-of-a-machine-learning-method-for-predicting-highly-cited-articles-within-general-radiology-journals
#11
Andrew B Rosenkrantz, Ankur M Doshi, Luke A Ginocchio, Yindalon Aphinyanaphongs
RATIONALE AND OBJECTIVES: This study aimed to assess the performance of a text classification machine-learning model in predicting highly cited articles within the recent radiological literature and to identify the model's most influential article features. MATERIALS AND METHODS: We downloaded from PubMed the title, abstract, and medical subject heading terms for 10,065 articles published in 25 general radiology journals in 2012 and 2013. Three machine-learning models were applied to predict the top 10% of included articles in terms of the number of citations to the article in 2014 (reflecting the 2-year time window in conventional impact factor calculations)...
December 2016: Academic Radiology
https://www.readbyqxmd.com/read/27677669/glyphosate-rodent-carcinogenicity-bioassay-expert-panel-review
#12
Gary M Williams, Colin Berry, Michele Burns, Joao Lauro Viana de Camargo, Helmut Greim
Glyphosate has been rigorously and extensively tested for carcinogenicity by administration to mice (five studies) and to rats (nine studies). Most authorities have concluded that the evidence does not indicate a cancer risk to humans. The International Agency for Research on Cancer (IARC), however, evaluated some of the available data and concluded that glyphosate probably is carcinogenic to humans. The expert panel convened by Intertek assessed the findings used by IARC, as well as the full body of evidence and found the following: (1) the renal neoplastic effects in males of one mouse study are not associated with glyphosate exposure, because they lack statistical significance, strength, consistency, specificity, lack a dose-response pattern, plausibility, and coherence; (2) the strength of association of liver hemangiosarcomas in a different mouse study is absent, lacking consistency, and a dose-response effect and having in high dose males only a significant incidence increase which is within the historical control range; (3) pancreatic islet-cell adenomas (non-significant incidence increase), in two studies of male SD rats did not progress to carcinomas and lacked a dose-response pattern (the highest incidence is in the low dose followed by the high dose); (4) in one of two studies, a non-significant positive trend in the incidence of hepatocellular adenomas in male rats did not lead to progression to carcinomas; (5) in one of two studies, the non-significant positive trend in the incidence of thyroid C-cell adenomas in female rats was not present and there was no progression of adenomas to carcinomas at the end of the study...
September 2016: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/27669229/the-epidermal-growth-factor-receptor-egfr-inhibitor-gefitinib-reduces-but-does-not-prevent-tumorigenesis-in-chemical-and-hormonal-induced-hepatocarcinogenesis-rat-models
#13
Silvia Ribback, Verena Sailer, Enrico Böhning, Julia Günther, Jaqueline Merz, Frauke Steinmüller, Kirsten Utpatel, Antonio Cigliano, Kristin Peters, Maria G Pilo, Matthias Evert, Diego F Calvisi, Frank Dombrowski
Activation of the epidermal growth factor receptor (EGFR) signaling pathway promotes the development of hepatocellular adenoma (HCA) and carcinoma (HCC). The selective EGFR inhibitor Gefitinib was found to prevent hepatocarcinogenesis in rat cirrhotic livers. Thus, Gefitinib might reduce progression of pre-neoplastic liver lesions to HCC. In short- and long-term experiments, administration of N-Nitrosomorpholine (NNM) or intrahepatic transplantation of pancreatic islets in diabetic (PTx), thyroid follicles in thyroidectomized (TTx) and ovarian fragments in ovariectomized (OTx) rats was conducted for the induction of foci of altered hepatocytes (FAH)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27664318/methyl-isobutyl-ketone-induced-hepatocellular-carcinogenesis-in-b6c3f1-mice-a-constitutive-androstane-receptor-car-mediated-mode-of-action
#14
B J Hughes, J Thomas, A M Lynch, S J Borghoff, S Green, T Mensing, S S Sarang, M J LeBaron
In a National Toxicology Program (NTP) chronic inhalation study with methyl isobutyl ketone (MIBK), increases in hepatocellular adenomas and hepatocellular adenomas and carcinomas (combined) were observed in male and female B6C3F1 mice at 1800 ppm. A DNA reactive Mode-of-Action (MOA) for this liver tumor response is not supported by the evidence as MIBK and its major metabolites lack genotoxicity in both in vitro and in vivo studies. Constitutive androstane receptor (CAR) nuclear receptor-mediated activation has been hypothesized as the MOA for MIBK-induced mouse liver tumorigenesis...
November 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27660679/contrast-enhanced-ultrasonographic-findings-of-serum-amyloid-a-positive-hepatocellular-neoplasm-does-hepatocellular-adenoma-arise-in-cirrhotic-liver
#15
Mariko Kumagawa, Naoki Matsumoto, Yukinobu Watanabe, Midori Hirayama, Takao Miura, Hiroshi Nakagawara, Masahiro Ogawa, Shunichi Matsuoka, Mitsuhiko Moriyama, Tadatoshi Takayama, Masahiko Sugitani
Hepatocellular adenoma (HCA) was recently classified into four pathological subtypes. There have been few studies describing the findings of contrast-enhanced ultrasonography (CEUS) of each type. Our case concerns a 78-year-old man who had undergone routine medical check-ups for hepatitis C for 11 years. Abdominal ultrasonography showed a 28 mm, hypo-echoic mass in the segment 4 of the liver. His integrating amount of drinking was 670 kg convert into ethanol. CEUS with Sonazoid demonstrated mild uniform hypo-enhancement with inflow of microbubbles from the periphery of the tumor in the arterial phase, and heterogeneously hypo-enhancement in the post vascular phase...
September 18, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27650020/-diagnostics-and-treatment-of-hepatocellular-adenomas
#16
A J Klompenhouwer, R A de Man, M G J Thomeer, M Doukas, J N M IJzermans
- Hepatocellular adenomas are essentially benign tumours of the liver that occur mostly in women of reproductive age. - The four different subtypes described, which can be distinguished both radiologically and histopathologically, are: steatotic, inflammatory, β-catenin mutated and unclassified adenomas. These subtypes differ in the risk of complications.- Contrast-enhanced liver MRI is the best method for diagnostics and characterization of hepatocellular adenomas. - Possible complications include bleeding, rupture, and malignant degeneration of the hepatocellular adenoma...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27627051/braf-v600e-mutation-in-biliary-proliferations-associated-with-%C3%AE-1-antitrypsin-deficiency
#17
Napat Angkathunyakul, Francesca Rosini, Nigel Heaton, Pierre Foskett, Alberto Quaglia
AIMS: Both homozygous and heterozygous α1 -antitrypsin (AAT) deficiency patients are at risk of developing hepatocellular carcinoma (HCC), but also of developing cholangiocarcinoma and combined HCC and cholangiocarcinoma. The aim of our study is to report a series of bile duct adenomas (BDAs) and intrahepatic cholangiocarcinoma (ICCs) in adult AAT deficiency patients, observed in our institution over a 5-year period. Our observational study includes a detailed investigation of their immunohistochemical profile and BRAF V600E mutation status...
September 14, 2016: Histopathology
https://www.readbyqxmd.com/read/27593592/european-experience-of-573-liver-resections-for-hepatocellular-adenoma-a-cross-sectional-study-by-the-afc-hca-2013-study-group
#18
Alexis Laurent, Safi Dokmak, Jean-Charles Nault, François-René Pruvot, Jean-Michel Fabre, Christian Letoublon, Philippe Bachellier, Lorenzo Capussotti, Olivier Farges, Jean-Yves Mabrut, Yves-Patrice Le Treut, Ahmet Ayav, Bertrand Suc, Olivier Soubrane, Gilles Mentha, Irinel Popescu, Marco Montorsi, Nicolas Demartines, Jacques Belghiti, Guido Torzilli, Daniel Cherqui, Jean Hardwigsen
BACKGROUND: Hepatocellular adenoma (HCA) is a benign hepatic lesion that may be complicated by bleeding and malignant transformation. The aim of the present study is to report on large series of liver resections for HCA and assess the incidence of hemorrhage and malignant transformation. METHODS: A retrospective cross-sectional study, from 27 European high-volume HPB units. RESULTS: 573 patients were analyzed. The female: male gender ratio was 8:2, mean age: 37 ± 10 years...
September 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27553837/long-term-outcomes-of-resection-in-patients-with-symptomatic-benign-liver-tumours
#19
Belle V van Rosmalen, Matthanja Bieze, Marc G H Besselink, Pieter Tanis, Joanne Verheij, Saffire S K S Phoa, Olivier Busch, Thomas M van Gulik
BACKGROUND: Benign liver tumours (e.g., hepatocellular adenoma (HCA), focal nodular hyperplasia (FNH), and haemangioma) are occasionally resected for alleged symptoms, although data on long-term outcomes is lacking. The aim of this cross-sectional study was to assess long-term outcomes of surgical intervention. METHODS: Forty patients with benign tumours (HCA 20, FNH 12, giant haemangioma 4, cysts 4) were included. Patients filled in Validated McGill Pain Questionnaires, preoperatively and after a median of 54 months after resection...
August 20, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27524464/evidence-of-good-prognosis-of-hepatocellular-adenoma-in-post-menopausal-women
#20
Anne Julia Klompenhouwer, Dave Sprengers, Franҫois Etienne Johan Antoine Willemssen, Marcia Patricia Gaspersz, Jan Nicolaas Maria Ijzermans, Robert Auke De Man
BACKGROUND & AIMS: Hepatocellular adenoma (HCA) is a rare benign liver tumor, which typically develops in women in their reproductive phase and is associated with the use of oral contraceptives. The aim of this study was to evaluate whether follow-up of HCA can be safely terminated after the occurrence of menopause. Secondary, we studied the impact of the diagnosis HCA on health-related quality of life (HRQoL). METHODS: This was a cross-sectional cohort study, including 48 post-menopausal women with HCA...
August 12, 2016: Journal of Hepatology
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