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Hepatocellular adenoma

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https://www.readbyqxmd.com/read/28820464/enhanced-susceptibility-of-ogg1-mutant-mice-to-multiorgan-carcinogenesis
#1
Anna Kakehashi, Naomi Ishii, Takahiro Okuno, Masaki Fujioka, Min Gi, Hideki Wanibuchi
The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2'-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice. A total of 80 male and female six-week-old mice of C57BL/6J background carrying a mutant Mmh allele of the Mmh/Ogg1 gene (Ogg1(-)(/)(-)) and wild type (Ogg1(+/+)) mice were administered N-diethylnitrosamine (DEN), N-methyl-N-nitrosourea (MNU), N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), N-bis (2-hydroxypropyl) nitrosamine (DHPN) and 1,2-dimethylhydrazine dihydrochloride (DMH) (DMBDD) to induce carcinogenesis in multiple organs, and observed up to 34 weeks...
August 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28759385/physical-activity-sedentary-behaviour-diet-and-cancer-an-update-and-emerging-new-evidence
#2
REVIEW
Jacqueline Kerr, Cheryl Anderson, Scott M Lippman
The lifestyle factors of physical activity, sedentary behaviour, and diet are increasingly being studied for their associations with cancer. Physical activity is inversely associated with and sedentary behaviour is positively (and independently) associated with an increased risk of more than ten types of cancer, including colorectal cancer (and advanced adenomas), endometrial cancers, and breast cancer. The most consistent dietary risk factor for premalignant and invasive breast cancer is alcohol, whether consumed during early or late adult life, even at low levels...
August 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28743375/a-model-based-prediction-of-the-probability-of%C3%A2-hepatocellular%C3%A2-adenoma-and-focal-nodular-hyperplasia%C3%A2-based%C3%A2-on-characteristics-on-contrast-enhanced%C3%A2-ultrasound
#3
Pavel Taimr, Mirelle E E Bröker, Roy S Dwarkasing, Bettina E Hansen, Robert J de Knegt, Robert A De Man, Jan N M IJzermans
Contrast-enhanced ultrasound (CEUS) is an emerging imaging technique that is increasingly used to diagnose liver lesions. It is of the utmost importance to differentiate between the two most common solid focal liver lesions (i.e., hepatocellular adenoma [HCA] and focal nodular hyperplasia [FNH]), because their management and follow-up differ greatly. The main objective of this study was to determine how frequently the specific CEUS features of HCA and FNH are visible on CEUS and to define their predictive value for discrimination between HCA and FNH...
July 22, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28740346/management-and-outcome-of-hepatocellular-adenoma-with-massive-bleeding-at-presentation
#4
Anne J Klompenhouwer, Robert A de Man, Maarten Gj Thomeer, Jan Nm Ijzermans
AIM: To evaluate outcome of acute management and risk of rebleeding in patients with massive hemorrhage due to hepatocellular adenoma (HCA). METHODS: This retrospective cohort study included all consecutive patients who presented to our hospital with massive hemorrhage (grade II or III) due to ruptured HCA and were admitted for observation and/or intervention between 1999-2016. The diagnosis of HCA was based on radiological findings from contrast-enhanced magnetic resonance imaging (MRI) or pathological findings from biopsy or resection of the HCA...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28733222/molecular-classification-of-hepatocellular-adenoma-in-clinical-practice
#5
REVIEW
Jean-Charles Nault, Valérie Paradis, Daniel Cherqui, Valérie Vilgrain, Jessica Zucman-Rossi
Hepatocellular adenomas (HCA) are rare benign liver tumors occurring in young women taking contraception. They are associated with rare complications such as bleeding or malignant transformation into hepatocellular carcinoma. A molecular classification has divided HCA in several subgroups linked with risk factors, clinical behaviour, histological features and imaging: HNF1A inactivated HCA, Inflammatory HCA, CTNNB1 mutated HCA in exon 3, CTNNB1 mutated in exon 7 and 8 HCA, sonic hedgehog HCA and unclassified HCA...
July 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28727971/congenital-extrahepatic-portosystemic-shunt-abernethy-malformation-type-ib-with-associated-hepatocellular-carcinoma-case-report-and-literature-review
#6
Mark Benedict, Manuel Rodriguez-Davalos, Sukru Emre, Zenta Walther, Raffaella Morotti
Abernethy malformation, also termed congenital portosystemic shunt and congenital absence of portal vein is the result of malformation of the splanchnic venous system. Congenital portosystemic shunts are divided into extra- and intrahepatic shunts. Two shunts have been defined: Type I is characterized by the complete diversion of portal blood into the vena cava with an associated congenital absence of the portal vein. Type II is defined by an intact but diverted portal vein through a side-to-side, extrahepatic connection to the vena cava...
July 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28726119/a-cost-effectiveness-analysis-of-the-diagnostic-strategies-for-differentiating-focal-nodular-hyperplasia-from-hepatocellular-adenoma
#7
Chong Hyun Suh, Kyung Won Kim, Seong Ho Park, Sangjin Shin, Jeonghoon Ahn, Junhee Pyo, Atul B Shinagare, Katherine M Krajewski, Nikhil H Ramaiya
OBJECTIVES: We evaluated the cost-effectiveness of a gadoxetic acid-enhanced MRI (EOB-MRI) strategy compared with conventional MRI strategy and biopsy to differentiate focal nodular hyperplasia (FNH) from hepatocellular adenoma (HCA). METHODS: A decision tree model was constructed to compare the cost-effectiveness of EOB-MRI, conventional MRI with extracellular contrast agents, and biopsy as the initial diagnostic modality in patients with incidentally detected focal liver lesions suspected of being FNH or HCA...
July 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28709169/the-challenge-of-liver-resection-in-benign-solid-liver-tumors-in-modern-times-in-which-cases-should-surgery%C3%A2-be-done
#8
Hans-Michael Hau, Anne Kloss, Georg Wiltberger, Nora Jahn, Felix Krenzien, Christian Benzing, Moritz Schmelzle, Daniel Seehofer, Georgi Atanasov, Michael Bartels
Background Due to improved diagnostical and therapeutical approaches, benign liver tumors represent a challenge in clinical management. We here report our experience with patients undergoing liver resection for benign liver tumors. Methods 188 One hundred eighty-eight consecutive patients, who underwent surgery for solid benign liver tumors from 1992 - 2014, were analyzed retrospectively. The focus was on diagnostic pathways, indications for surgery, and perioperative and postoperative quality of life (QoL)...
July 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28704224/inflammatory-and-multiple-hepatocellular-adenoma-are-associated-with-a-higher-bmi
#9
Mirelle E E Bröker, Marcia P Gaspersz, Anne J Klompenhouwer, Bettina E Hansen, Turkan Terkivatan, Pavel Taimr, Roy Dwarkasing, Maarten G J Thomeer, Robert A de Man, Jan N M IJzermans
AIM: To identify patient and lesion characteristics associated with the occurrence of single or multiple hepatocellular adenoma (HCA). PATIENTS AND METHODS: Using a tertiary centre database, we retrospectively collected information on patient and lesion characteristics, management and follow-up of all patients with HCA included between 2001 and 2016. Patients were classified into three groups; patients with a single HCA, 2-9 HCA and at least 10 HCA. RESULTS: A total of 458 patients were diagnosed with HCA, including 121 (26...
July 12, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28676441/chronic-toxicity-and-oncogenicity-of-octamethylcyclotetrasiloxane-d4-in-the-fischer-344-rat
#10
Paul A Jean, Kathleen P Plotzke
Octamethylcyclotetrasiloxane (D4) is a cyclic volatile methylsiloxane primarily used in the synthesis of silicon-based materials used in in a variety of consumer products. This paper details the chronic toxicity and oncogenicity evaluation of D4 in the Fischer 344 rat. Animals were exposed to 0, 10, 30, 150, or 700ppm D4 vapor for 6h/day, 5 days/week for up to 104 weeks in whole-body inhalation chambers. Effects of two year chronic exposure included increased liver, kidney, testes, and uterine weight with correlating microscopic findings of hepatocellular hypertrophy (males only), chronic nephropathy (both sexes), interstitial cell hyperplasia, and cystic endometrial hyperplasia and endometrial adenoma, respectively...
July 1, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28646562/argininosuccinate-synthase-1-ass1-a-marker-of-unclassified-hepatocellular-adenoma-and-high-bleeding-risk
#11
Elodie Henriet, Aya Abou Hammoud, Jean-William Dupuy, Benjamin Dartigues, Zakaria Ezzoukry, Nathalie Dugot-Senant, Thierry Leste-Lasserre, Nestor Pallares-Lupon, Macha Nikolski, Brigitte Le Bail, Jean-Frédéric Blanc, Charles Balabaud, Paulette Bioulac-Sage, Anne-Aurélie Raymond, Frédéric Saltel
Hepatocellular adenomas (HCA) are rare benign tumors divided into three main subgroups defined by patho-molecular features, HNF1A (H-HCA), mutated β-catenin (b-HCA) and inflammatory (IHCA). In the case of unclassified HCA (UHCA), which are currently identified by default, a high risk of bleeding remains a clinical issue. The objective of this study was to explore UHCA proteome with the aim to identify specific biomarkers. Following dissection of the tumoral (T) and non-tumoral (NT) tissue on formalin-fixed paraffin-embedded (FFPE) from HCA tissue sections using laser capture methodology, we performed mass spectrometry analysis to compare T and NT protein expression levels in HCA, H-HCA, IHCA, b-HCA, UHCA and focal nodular hyperplasia...
June 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28635168/malignant-potential-of-hepatocellular-adenoma
#12
EDITORIAL
Anne J Klompenhouwer, Jan N M IJzermans
No abstract text is available yet for this article.
July 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28626210/clinical-correspondence-to-hepatocellular-carcinoma-related-lesions-with-atypical-radiological-pattern
#13
Tokio Higaki, Yutaka Midorikawa, Yosuke Nakashima, Hisashi Nakayama, Shunichi Matsuoka, Mitsuhiko Moriyama, Masahiko Sugitani, Tadatoshi Takayama
In patients at risk of hepatocarcinogenesis, tumors are frequently detected with atypical radiological patterns related to hepatocellular carcinoma (HCC) on imaging studies. Despite their high potential for malignancy, whether to resect such lesions immediately is controversial. Based on histological findings, patients with non-enhanced tumors or enhanced tumors without washout were divided into two groups: those with tumors that should be treated containing well, moderately, and poorly differentiated HCC (Group 1), and those that can be observed containing early HCC, hepatocellular adenoma, focal nodular hyperplasia, dysplastic nodules, and regenerative nodules (Group 2), and we elucidated the clinical correspondence to these tumors...
June 18, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28623793/tributyl-phosphate-impairs-the-urea-cycle-and-alters-liver-pathology-and-metabolism-in-mice-after-short-term-exposure-based-on-a-metabonomics-study
#14
Lili Zhou, Wenpeng Zhang, Wenping Xie, Huiming Chen, Wenlian Yu, Haishan Li, Guolin Shen
As a newly emerging environmental contaminant, tributyl phosphate (TBP) is of increasing concern because of the environmental problems it can cause. Studies have suggested that TBP induces hepatocellular adenomas and has malignant potential for hepatocellular carcinoma. However, the mechanisms of its adverse effects are unclear. In this study, metabonomic techniques were used to identify differential endogenous metabolites, draw network metabolic pathways and conduct network analysis to elucidate the underlying mechanisms involved in TBP induced pathological changes of the liver...
June 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28618047/focal-b-catenin-mutation-identified-on-formalin-fixed-and-paraffin-embedded-inflammatory-hepatocellular-adenomas
#15
Joan Saldarriaga, Bettina Bisig, Gabrielle Couchy, Claire Castain, Jessica Zucman-Rossi, Charles Balabaud, Christine Sempoux, Paulette Bioulac-Sage
The identification of hepatocellular adenoma (HCA) with mutation in exon 3 of the CTNNB1 gene encoding for b-catenin is clinically relevant due to higher risk of malignant transformation. Inflammatory HCA (IHCA) can exhibit b-catenin activation (b-IHCA). We report 2 cases with multiple IHCA in which focal b-catenin activation has been found in one of the IHCA. In both cases, the diagnosis of IHCA was confirmed on the resected nodules by routine stains, immunohistochemical detection of C-reactive protein (CRP), and molecular biology on frozen material...
June 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28607606/diagnostic-value-of-gd-eob-dtpa-mri-for-hepatocellular-adenoma-a-meta-analysis
#16
Yongfei Guo, Wenjuan Li, Zhinan Xie, Yi Zhang, Yijie Fang, Wenli Cai, Guobin Hong
Objective: This study aimed to systematically review the gadoxetic acid-enhanced magnetic resonance imaging (Gd-EOB-DTPA-MRI) findings of hepatocellular adenoma (HCA), especially focusing on the diagnostic value of low signal intensity (SI) in the hepatocyte-phase (HBP) for differentiating HCA from focal nodular hyperplasia (FNH). Methods: A thorough literature search was conducted in PubMed, Excerpta Medica Database (EMBASE) and China National Knowledge Infrastructure databases (CNKI) to identify studies evaluating Gd-EOB-DTPA-MRI presentations of HCA...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28593805/ectopic-liver-within-the-placental-parenchyma-of-a-stillborn-fetus
#17
Rasleen Saluja, Ona Faye-Petersen, Debra S Heller
Rarely, liver tissue can be seen in the umbilical cord, where it is thought to result from ectopic localization during embryogenesis. The placental parenchyma is also a rare site for this occurrence. The exact pathophysiology of ectopic liver in the placenta is unknown. It has been considered that aberrant migration or displacement of cells from the developing hepatic buds leads to ectopic liver formation, including groups of liver cells that become entrapped in the foregut as the diaphragm closes. Additional hypotheses put forward have included monodermal teratoma and hepatocellular adenoma...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28590780/intravoxel-incoherent-motion-and-dynamic-contrast-enhanced-mri-for-differentiation-between-hepatocellular-adenoma-and-focal-nodular-hyperplasia
#18
Naim Jerjir, Luk Bruyneel, Marc Haspeslagh, Sarah Quenet, Kenneth Coenegrachts
OBJECTIVE: To examine if intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced MRI (DCE-MRI) can be used as new and supplemental MRI techniques to differentiate hepatocellular adenomas (HCAs) from focal nodular hyperplasias (FNHs) and analyse if diffusion parameter apparent diffusion coefficient (ADC) and IVIM parameter true diffusion coefficient (D) differ in doing so. METHODS: This prospective study included 21 patients (8 HCAs and 13 FNHs) who underwent a specifically designed MRI scanning protocol, including series for analysis of IVIM (four b-values 0, 10, 150 and 800 s mm(-2)) and DCE-MRI...
August 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28580885/%C3%AE-catenin-mutations-are-not-involved-in-early-stage-hepatocarcinogenesis-induced-by-protoporphyrinogen-oxidase-inhibitors-in-mice
#19
Kazunori Kuwata, Kaoru Inoue, Ryohei Ichimura, Miwa Takahashi, Yukio Kodama, Makoto Shibutani, Midori Yoshida
We previously reported the contribution of constitutive androstane receptor (CAR) in cytotoxicity-related hepatocarcinogenesis induced by oxadiazon (OX) or acifluorfen (ACI), two pesticides categorized as protoporphyrinogen oxidase (PROTOX) inhibitors. The molecular characteristics of preneoplastic and neoplastic lesions induced by OX and ACI were immunohistochemically compared to those by phenobarbital (PB), a typical CAR activator, in wild-type (WT) and CAR knockout (CARKO) mice after diethylnitrosamine initiation...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28535153/high-energy-particle-beam-and-gamma-radiation-exposure-familial-relatedness-and-cancer-in-mice
#20
Pavel Chernyavskiy, Elijah F Edmondson, Michael M Weil, Mark P Little
BACKGROUND: Some highly penetrant familial cancer syndromes exhibit elevated leukaemia risk, and there is evidence for familial clustering of lung cancer and other common cancers. Lung cancer and leukaemia are strongly radiogenic, but there are few indications that high-energy beam irradiation is markedly more effective than lower-energy radiation. METHODS: We used a Cox model with familially structured random effects to assess 16 mortality end points in a group of 1850 mice in 47 families maintained in a circular-breeding scheme, exposed to accelerated Si or Fe ions (0...
June 27, 2017: British Journal of Cancer
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