keyword
MENU ▼
Read by QxMD icon Read
search

Hepatocellular adenoma

keyword
https://www.readbyqxmd.com/read/29663940/ezh2-expression-in-naturally-occurring-canine-tumors
#1
Hyun-Ji Choi, Han-Byul Lee, Hyun-Kyu Park, Sung-Min Cho, Hyo-Jeong Han, Sang-Joon Lee, Ji-Young Lee, Su-Jeong Nam, Eun-Ho Cho, Woo-Chan Son
Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in various normal and tumorous dog tissues and compared these patterns with those of the corresponding human tissues. Immunohistochemical analysis showed positive staining for EZH2 in 76 of 82 cases of canine tumors, whereas low or negligible staining occurred in normal tissues and other canine tumors, including hepatocellular adenoma and lipoma...
April 2, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29663270/molecular-biology-and-gene-therapy-for-glycogen-storage-disease-type-ib
#2
Janice Y Chou, Jun-Ho Cho, Goo-Young Kim, Brian C Mansfield
Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the ubiquitously expressed glucose-6-phosphate (G6P) transporter (G6PT or SLC37A4). The primary function of G6PT is to translocate G6P from the cytoplasm into the lumen of the endoplasmic reticulum (ER). Inside the ER, G6P is hydrolyzed to glucose and phosphate by either the liver/kidney/intestine-restricted glucose-6-phosphatase-α (G6Pase-α) or the ubiquitously expressed G6Pase-β. A deficiency in G6Pase-α causes GSD type Ia (GSD-Ia) and a deficiency in G6Pase-β causes GSD-I-related syndrome (GSD-Irs)...
April 16, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29649004/atypical-hepatocellular-neoplasms-review-of-clinical-morphologic-immunohistochemical-molecular-and-cytogenetic-features
#3
Won-Tak Choi, Sanjay Kakar
The distinction of hepatocellular adenoma from well-differentiated hepatocellular carcinoma (HCC) can be difficult in some cases, especially on biopsy specimens. These borderline cases often occur in men or older patients and may have β-catenin activation or focal atypical morphologic features (such as small cell change, prominent pseudoacinar formation, cytologic atypia, focally thick plates, and/or focal reticulin loss) that are insufficient for an unequivocal diagnosis of HCC. The term "atypical hepatocellular neoplasm" has been advocated for these tumors, but a number of other terms, including "atypical adenoma," "hepatocellular neoplasm of uncertain malignant potential," and "well-differentiated hepatocellular neoplasm with atypical or borderline features" have also been proposed...
April 11, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29594465/interpreting-body-mri-cases-classic-findings-in-abdominal-mri
#4
REVIEW
Leann Kania, Flavius Guglielmo, Donald Mitchell
Few things in radiology are "pathognomonic" in their appearance or presentation. However, having an awareness of those findings which are specific to a certain entity is important when interpreting imaging studies. These classic findings can be identified with many imaging modalities, but no modality provides as many recognizable observations as an MRI. This results from the large variety of pulse sequences that provide high contrast resolution, prior to and following contrast administration. In this article, the most classically recognized abdominal findings are presented including the following: Liver: Cyst, hemangioma, focal nodular hyperplasia, hepatic adenoma, hemosiderosis, hepatocellular carcinoma...
March 28, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29589251/hepatocellular-adenoma-in-a-woman-who-was-undergoing-testosterone-treatment-for-gender-identity-disorder
#5
Keizo Kato, Hiroshi Abe, Noriko Hanawa, Junya Fukuzawa, Ryota Matsuo, Takeshi Yonezawa, Sadahiro Itoh, Yoshiyuki Sato, Makiko Ika, Shohei Shimizu, Shinji Endo, Hiroshi Hano, Asami Izu, Masahiko Sugitani, Akihito Tsubota
A 32-year-old Japanese woman was admitted to our hospital for the diagnosis and treatment of multiple liver tumors. She had been receiving 125 mg testosterone enanthate every 2 weeks following female-to-male gender identity disorder (GID) diagnosis at 20 years of age. Ultrasonography, computed tomography, and magnetic resonance imaging showed 11 hepatic nodular tumors with a maximum diameter of 28 mm. Liver tumors with hepatocellular adenoma (HCA) were diagnosed with needle biopsy. Segmentectomy of the left lateral lobe including two lesions, subsegmentectomy of S6 including two lesions, enucleation of each tumor in S5 and S7, and open surgical radiofrequency ablation for each tumor in S4 and S7 were performed...
March 27, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29581770/targeting-hepatocarcinogenesis-model-in-c56bl6-mice-with-pan-aurora-kinase-inhibitor-danusertib
#6
Paschalis Gavriilidis, Theofilos Poutahidis, Alexander Giakoustidis, Kali Makedou, Katerina Angelopoulou, Alexander Hardas, Paola Andreani, Argyro Zacharioudaki, George Saridis, Athanasios Gargavanis, Eleni Louri, Nikolaos Antoniadis, Eleftheria Karampela, Nikolaos Psychalakis, Antonios Michalopoulos, Apostolos Papalois, Stavros Iliadis, Satvinder Mudan, Daniel Azoulay, Dimitrios Giakoustidis
Background : To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods : Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis with diethylnitrosamine (DEN), and Group C animals with DEN-induced hepatocarcinogenenesis that treated with pan-aurora kinase inhibitor Danusertib. Primary antibodies for immunochistochemistry (IHC) included rabbit antibodies against Ki-67, DKK1, INCENP, cleaved caspase-3, NF-κB p65, c-Jun, β-catenin...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29576889/recent-development-and-gene-therapy-for-glycogen-storage-disease-type-ia
#7
Janice Y Chou, Goo-Young Kim, Jun-Ho Cho
Glycogen storage disease type Ia (GSD-Ia) is an autosomal recessive metabolic disorder caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) that is expressed primarily in the liver, kidney, and intestine. G6Pase-α catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate in the terminal step of gluconeogenesis and glycogenolysis, and is a key enzyme for endogenous glucose production. The active site of G6Pase-α is inside the endoplasmic reticulum (ER) lumen. For catalysis, the substrate G6P must be translocated from the cytoplasm into the ER lumen by a G6P transporter (G6PT)...
September 2017: Liver Research
https://www.readbyqxmd.com/read/29572896/ass1-and-peri-portal-gene-expression-in-sonic-hedgehog-hepatocellular-adenomas
#8
Jean-Charles Nault, Gabrielle Couchy, Stefano Caruso, Léa Meunier, Laure Caruana, Eric Letouzé, Sandra Rebouissou, Valérie Paradis, Julien Calderaro, Jessica Zucman-Rossi
INTRODUCTION: Genetic alterations define different molecular subclasses of hepatocellular adenoma (HCA) linked with risk factors, histology and clinical behavior. Recently, ASS1, a major peri-portal protein, was proposed as a marker of HCA with a high risk of hemorrhage. We aimed to assess the significance of ASS1 expression through the scope of the HCA molecular classification. METHODS: ASS1 expression was evaluated using RNAseq, quantitative RT-PCR and Immunohistochemistry...
March 24, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29570181/-benign-liver-tumours-current-diagnostics-and-therapeutic-modalities
#9
Gergely Nagy, Katalin Dezsõ, Gergely Kiss, Zsuzsanna Gerlei, Péter Nagy, László Kóbori
The most common benign liver tumours are haemangiomas, focal nodular hyperplasia and hepatocellular adenoma. We perform a review of the literature and show the current diagnostic and therapeutic modalities based on the EASL Clinical Practice Guideline. With the widespread use of ultrasound, the detection of liver lesions is increased. They are usually found in women of childbearing age with atypical abdominal pain or incidentally. Contrast-enhanced US, CT or MRI are usually necessary for differential diagnosis...
March 23, 2018: Magyar Onkologia
https://www.readbyqxmd.com/read/29567877/a-practical-diagnostic-approach-to-hepatic-masses
#10
REVIEW
Monika Vyas, Dhanpat Jain
The differential diagnosis of hepatic mass lesions is broad and arriving at the right diagnosis can be challenging, especially on needle biopsies. The differential diagnosis of liver tumors in children is different from adults and is beyond the scope of this review. In adults, the approach varies depending on the age, gender, and presence of background liver disease. The lesions can be divided broadly into primary and metastatic (secondary), and the primary lesions can be further divided into those of hepatocellular origin and nonhepatocellular origin...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29555032/is-bariatric-surgery-a-potential-new-treatment-for-large-inflammatory-hepatocellular-adenomas-in-obese-patients
#11
Iman Khaoudy, Lionel Rebibo, Jean-Marc Regimbeau
No abstract text is available yet for this article.
April 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29545603/notch2-controls-hepatocyte-derived-cholangiocarcinoma-formation-in-mice
#12
Jingxiao Wang, Mingjie Dong, Zhong Xu, Xinhua Song, Shanshan Zhang, Yu Qiao, Li Che, John Gordan, Kaiwen Hu, Yan Liu, Diego F Calvisi, Xin Chen
Liver cancer comprises a group of malignant tumors, among which hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most common. ICC is especially pernicious and associated with poor clinical outcome. Studies have shown that a subset of human ICCs may originate from mature hepatocytes. However, the mechanisms driving the trans-differentiation of hepatocytes into malignant cholangiocytes remain poorly defined. We adopted lineage tracing techniques and an established murine hepatocyte-derived ICC model by hydrodynamic injection of activated forms of AKT (myr-AKT) and Yap (YapS127A) proto-oncogenes...
March 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29545180/hepatic-glucose-6-phosphatase-%C3%AE-deficiency-leads-to-metabolic-reprogramming-in-glycogen-storage-disease-type-ia
#13
Jun-Ho Cho, Goo-Young Kim, Brian C Mansfield, Janice Y Chou
Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC), a key enzyme in endogenous glucose production. This autosomal recessive disorder is characterized by impaired glucose homeostasis and long-term complications of hepatocellular adenoma/carcinoma (HCA/HCC). We have shown that hepatic G6Pase-α deficiency-mediated steatosis leads to defective autophagy that is frequently associated with carcinogenesis. We now show that hepatic G6Pase-α deficiency also leads to enhancement of hepatic glycolysis and hexose monophosphate shunt (HMS) that can contribute to hepatocarcinogenesis...
March 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29516774/hepatic-adenoma-arising-in-a-patient-with-alagille-syndrome-a-case-report
#14
M Cristina Pacheco, Eric J Monroe, Simon P Horslen
Alagille syndrome is associated with decreased bile ducts, cardiac abnormalities, vertebral body fusion defects, and a typical facies. While regenerative nodules and hepatocellular carcinoma have been described in these patients, hepatic adenoma has not. Herein, we present a patient with Alagille syndrome caused by a mutation in NOTCH2 with a hepatic adenoma. The clinical, imaging, and histologic features are discussed.
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29512829/hepatic-angiomyolipoma-mutation-analysis-and-immunohistochemical-pitfalls-in-diagnosis
#15
Zhen Yan, James P Grenert, Nancy M Joseph, Chuanli Xu, Xin Chen, Nafis Shafizadeh, Sanjay Kakar
AIMS: Hepatic angiomyolipoma (AML) often shows epithelioid morphology with inconspicuous fat. Epithelioid component can mimic hepatocellular adenoma (HCA) or carcinoma (HCC). The aims were to examine the expression of commonly used markers for HCA or HCC in hepatic AML, and highlight pitfalls in diagnosis. METHODS AND RESULTS: Resected hepatic AML (n=16) were reviewed; reticulin stain, immunohistochemistry for GS, β-catenin, LFABP were performed along with Sanger sequencing of exon 3 of CTNNB1 and next generation sequencing (NGS)...
March 7, 2018: Histopathology
https://www.readbyqxmd.com/read/29496071/mr-imaging-of-hepatocellular-adenomas-on-genotype-phenotype-classification-a-report-from-china
#16
Heqing Wang, Chun Yang, Shengxiang Rao, Yuan Ji, Jing Han, Ruofan Sheng, Mengsu Zeng
PURPOSE: To investigate and compare the MR features between hepatocellular adenoma (HCA) subtypes in China, including preliminary observations on diffusion-weighted imaging (DWI). METHODS: Thirty-six patients with 39 pathologically proven HCAs underwent gadopentetate dimeglumine enhanced MRI. The morphological and imaging features on T1, T2-weighted, dynamic-enhanced imaging and DWI were retrospectively evaluated and compared between four HCA subtypes, using Kruskal-Wallis test, Fisher's exact test and Dunn-Bonferroni post hoc test...
March 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29479033/carcinogenicity-of-quinoline-by-drinking-water-administration-in-rats-and-mice
#17
Michiharu Matsumoto, Hirokazu Kano, Masaaki Suzuki, Tadashi Noguchi, Yumi Umeda, Shoji Fukushima
The carcinogenicity of quinoline was examined by administrating quinoline in the drinking water to groups of 50 F344/DuCrj rats and 50 Crj: BDF1 mice of each sex. In rats, the doses of quinoline were 0, 200, 400, and 800 ppm for males and 0, 150, 300, and 600 ppm for females. In male rats, administration of quinoline was terminated at week 96 due to high mortality caused by tumors. There were significant increases of hepatocellular adenomas, hepatocellular carcinomas, hepatocellular adenomas and/or carcinomas (combined), and liver hemangiomas, hemangiosarcomas, hemangiomas and/or hemangiosarcomas (combined) in both male and female rats, and nasal esthesioneuroepitheliomas and sarcoma NOS (not otherwise specified) in males...
2018: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/29460044/mri-features-of-primary-hepatic-lymphoma
#18
Stefano Colagrande, Linda Calistri, Giulia Grazzini, Cosimo Nardi, Simone Busoni, Giovanni Morana, Luigi Grazioli
PURPOSE: Our retrospective study sought to describe the spectrum of magnetic resonance imaging (MRI) features of primary hepatic lymphoma (PHL) by analyzing its morphological aspects, signal intensity before and after contrast agent (CA) administration, and diffusion-weighted imaging (DwI) with the apparent diffusion coefficient (ADC) values. METHODS: A retrospective analysis was conducted on 25 patients with pathologically proven PHL who underwent MRI between January 2011 and December 2016...
February 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29460040/benign-and-malignant-hepatocellular-lesions-in-patients-with-vascular-liver-diseases
#19
Valérie Vilgrain, Valérie Paradis, Morgane Van Wettere, Dominique Valla, Maxime Ronot, Pierre-Emmanuel Rautou
A variety of vascular liver disorders can induce hepatocellular tumors. They may be related to portal venous deprivation, venous outflow obstruction, or arterial diseases. Their common feature is an imbalance between hepatic arterial and portal venous blood flow leading to an increased hepatic arterial inflow. Consequently, hepatocellular tumors may arise, most commonly focal nodular hyperplasia-like lesions but hepatocellular adenomas and hepatocellular carcinoma may be seen as well. This article will review the most common vascular liver diseases associated with hepatocellular nodules (Budd-Chiari syndrome, congenital portosystemic shunt, hereditary hemorrhagic telangiectasia, and portal cavernoma)...
February 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29424599/screening-of-biomarkers-for-liver-adenoma-in-low-dose-rate-gamma-ray-irradiated-mice
#20
Takashi Sugihara, Satoshi Tanaka, Ignacia Braga-Tanaka, Hayato Murano, Masako Nakamura-Murano, Jun-Ichiro Komura
PURPOSE: Chronic low-dose-rate (20 mGy/d) gamma-irradiation increases the incidence of hepatocellular adenomas (HCA) in female B6C3F1 mice. The purpose of this study is to identify potential serum biomarkers for these HCAs by a new approach. MATERIAL AND METHODS: Microarray analysis were performed to compare the gene expression profiles of HCAs from mice exposed to low-dose-rate gamma rays with those of normal livers from non-irradiated mice. From the differentially expressed genes, those for possibly secretory proteins were selected...
February 9, 2018: International Journal of Radiation Biology
keyword
keyword
118314
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"