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Selection process holistic

J Martín Martín, M Olano-Lizarraga, M Saracíbar-Razquin
INTRODUCTION: One of the key aspects of the care of terminal patients is care delivered in their own home. Increasingly, the process of dying is moving from hospitals to homes. Although this process is directly related to the support of the social health environment, the involvement of family caregivers is essential. Given the impact that caring for a terminally ill family member has on people's lives, it is necessary to comprehend their personal experience in a holistic way. OBJECTIVE: To reveal the experience of family caregivers who are caring for a terminal patient in their home...
September 14, 2016: International Journal of Nursing Studies
E-K Korduner, I Collin Bagewitz, P Vult von Steyern, E Wolf
The aim of this investigation was to study the clinical prosthodontic decision-making process relating to dentitions with compromised molars among Swedish general dental practitioners (GDPs). Eleven Swedish GDPs were purposively selected, and all agreed to participate. Then, in-depth, semi-structured interviews were conducted and covered treatment considerations concerning two authentic patient cases, initially with complete dental arches, and later, a final treatment based on a shortened dental arch (SDA) was discussed...
September 16, 2016: Journal of Oral Rehabilitation
Sarah S Conrad, Amy N Addams, Geoffrey H Young
Medical schools and residency programs have always sought excellence in the areas of education, research, and clinical care. However, these pursuits are not accomplished within a vacuum-rather, they are continually and necessarily influenced by social, cultural, political, legal, and economic forces. Persistent demographic inequalities coupled with rapidly evolving biomedical research and a complex legal landscape heighten our collective awareness and emphasize the continued need to consider medicine's social contract when selecting, educating, and developing physicians and physician-scientists...
September 13, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
John Towler, Martin Eimer
It is often assumed that upright faces are represented in a holistic fashion, while representations of inverted faces are essentially part-based. To assess this hypothesis, we recorded event-related potentials (ERPs) during a sequential face identity matching task where successively presented pairs of upright or inverted faces were either identical or differed with respect to their internal features, their external features, or both. Participants' task was to report on each trial whether the face pair was identical or different...
October 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
Shireen Madani Sims, James W Lynch
INTRODUCTION: The College of Medicine at our institution underwent a major curricular revision in order to develop a patient-centered context for learning. The admission process was revised to reflect this change, adopting a holistic review process, with the hope of attracting students who were particularly well suited to a patient-centered curriculum and learning culture. METHODS: Patients from a single practitioner, who were accustomed to working with medical students, were asked if they would like to select the next generation of physicians...
2016: Medical Education Online
Tamara D James, Timothy Cardozo, Lauren E Abell, Meng-Lun Hsieh, Lisa M Miller Jenkins, Saheli S Jha, Deborah M Hinton
The ability of RNA polymerase (RNAP) to select the right promoter sequence at the right time is fundamental to the control of gene expression in all organisms. However, there is only one crystallized structure of a complete activator/RNAP/DNA complex. In a process called σ appropriation, bacteriophage T4 activates a class of phage promoters using an activator (MotA) and a co-activator (AsiA), which function through interactions with the σ(70) subunit of RNAP. We have developed a holistic, structure-based model for σ appropriation using multiple experimentally determined 3D structures (Escherichia coli RNAP, the Thermus aquaticus RNAP/DNA complex, AsiA /σ(70) Region 4, the N-terminal domain of MotA [MotA(NTD)], and the C-terminal domain of MotA [MotA(CTD)]), molecular modeling, and extensive biochemical observations indicating the position of the proteins relative to each other and to the DNA...
September 19, 2016: Nucleic Acids Research
Winrich Freiwald, Bradley Duchaine, Galit Yovel
Primate face processing depends on a distributed network of interlinked face-selective areas composed of face-selective neurons. In both humans and macaques, the network is divided into a ventral stream and a dorsal stream, and the functional similarities of the areas in humans and macaques indicate they are homologous. Neural correlates for face detection, holistic processing, face space, and other key properties of human face processing have been identified at the single neuron level, and studies providing causal evidence have established firmly that face-selective brain areas are central to face processing...
July 8, 2016: Annual Review of Neuroscience
Silvia Bona, Zaira Cattaneo, Juha Silvanto
BACKGROUND: The right occipital face area (rOFA) is known to be involved in face discrimination based on local featural information. Whether this region is also involved in global, holistic stimulus processing is not known. OBJECTIVE: We used fMRI-guided transcranial magnetic stimulation (TMS) to investigate whether rOFA is causally implicated in stimulus detection based on holistic processing, by the use of Mooney stimuli. METHODS: Two studies were carried out: In Experiment 1, participants performed a detection task involving Mooney faces and Mooney objects; Mooney stimuli lack distinguishable local features and can be detected solely via holistic processing (i...
July 2016: Brain Stimulation
Reza Ghaemi, Ponnambalam R Selvaganapathy
Drug discovery is a long and expensive process, which usually takes 12-15 years and could cost up to ~$1 billion. Conventional drug discovery process starts with high throughput screening and selection of drug candidates that bind to specific target associated with a disease condition. However, this process does not consider whether the chosen candidate is optimal not only for binding but also for ease of administration, distribution in the body, effect of metabolism and associated toxicity if any. A holistic approach, using model organisms early in the drug discovery process to select drug candidates that are optimal not only in binding but also suitable for administration, distribution and are not toxic is now considered as a viable way for lowering the cost and time associated with the drug discovery process...
2016: Current Pharmaceutical Biotechnology
Martin Koller, Lukáš Maršálek, Miguel Miranda de Sousa Dias, Gerhart Braunegg
Sustainable production of microbial polyhydroxyalkanoate (PHA) biopolyesters on a larger scale has to consider the "four magic e": economic, ethical, environmental, and engineering aspects. Moreover, sustainability of PHA production can be quantified by modern tools of Life Cycle Assessment. Economic issues are to a large extent affected by the applied production mode, downstream processing, and, most of all, by the selection of carbon-rich raw materials as feedstocks for PHA production by safe and naturally occurring wild type microorganisms...
May 13, 2016: New Biotechnology
Nádia Canário, Lília Jorge, M F Loureiro Silva, Mário Alberto Soares, Miguel Castelo-Branco
The ventral visual pathway receives both inputs from parvocellular and magnocellular pathways, and combines information from distinct high and low spatial frequency channels (HSF and LSF). Using a random effects region of interest general linear model approach (n=21), we aimed to compare the selectivity to different spatial frequency channels in eight key areas involved in visual object recognition: FFA, OFA, and STS, for face processing; FBA, and EBA as body selective regions; (dorsal and ventral) LOC for object perception; PPA for processing information of places and VWFA as a region which responds to written verbal material...
July 1, 2016: Neuropsychologia
Richard A Goldstein, David D Pollock
The use of amino acid substitution matrices to model protein evolution has yielded important insights into both the evolutionary process and the properties of specific protein families. In order to make these models tractable, standard substitution matrices represent the average results of the evolutionary process rather than the underlying molecular biophysics and population genetics, treating proteins as a set of independently evolving sites rather than as an integrated biomolecular entity. With advances in computing and the increasing availability of sequence data, we now have an opportunity to move beyond current substitution matrices to more interpretable mechanistic models with greater fidelity to the evolutionary process of mutation and selection and the holistic nature of the selective constraints...
July 2016: Protein Science: a Publication of the Protein Society
Celia Laird O'Brien, Sandra M Sanguino, John X Thomas, Marianne M Green
PURPOSE: Portfolios are a powerful tool to collect and evaluate evidence of medical students' competence across time. However, comprehensive portfolio assessment systems that are implemented alongside traditional graded curricula at medical schools in the United States have not been described in the literature. This study describes the development and implementation of a longitudinal competency-based electronic portfolio system alongside a graded curriculum at a relatively large U.S. medical school...
March 29, 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Nazafarin Hosseini, Farkhondeh Sharif, Fazlollah Ahmadi, Mohammad Zare
BACKGROUND: Epilepsy exposes patients to many physical, social, and emotional challenges. Thus, it seems to portray a complex picture and needs holistic care. Medical treatment and psychosocial part of epilepsy remain central to managing and improving the patient's qualify of life through team efforts. Some studies have shown the dimensions of self-management, but its management process of epilepsy patients, especially in Iran, is not clear. This study aimed to determine the disease management process in patients with epilepsy in Iran...
January 2016: Iranian Journal of Nursing and Midwifery Research
José Alexandre Ferreira, Ana Magalhães, Joana Gomes, Andreia Peixoto, Cristiana Gaiteiro, Elisabete Fernandes, Lúcio Lara Santos, Celso A Reis
Glycosylation is the most frequent and structurally complex posttranslational modification in cell-surface and secreted proteins. Glycans are major orchestrators of biological processes, namely by controlling protein folding and key biological functions such as cell adhesion, migration, signaling and immune recognition. Altered glycosylation is considered a hallmark of malignant transformations that decisively contributes to disease outcome. This review comprehensively summarizes the main findings related with gastrointestinal cancers and the decisive impact of aberrant glycosylation on tumor biology towards more aggressive phenotypes...
January 29, 2016: Cancer Letters
Charles C Roseman
OBJECTIVES: This study assesses the extent to which relationships among groups complicate comparative studies of adaptation in recent human cranial variation and the extent to which departures from neutral additive models of evolution hinder the reconstruction of population relationships among groups using cranial morphology. MATERIALS AND METHODS: Using a maximum likelihood evolutionary model fitting approach and a mixed population genomic and cranial data set, I evaluate the relative fits of several widely used models of human cranial evolution...
August 2016: American Journal of Physical Anthropology
Josh P Davis, Andreea C Maigut, Darrick Jolliffe, Stuart J Gibson, Chris J Solomon
The paradigm detailed in this manuscript describes an applied experimental method based on real police investigations during which an eyewitness or victim to a crime may create from memory a holistic facial composite of the culprit with the assistance of a police operator. The aim is that the composite is recognized by someone who believes that they know the culprit. For this paradigm, participants view a culprit actor on video and following a delay, participant-witnesses construct a holistic system facial composite...
2015: Journal of Visualized Experiments: JoVE
Vuokko Pihlainen, Tuula Kivinen, Johanna Lammintakanen
Purpose - The purpose of this study is to describe the characteristics of management and leadership competence of health-care leaders and managers, especially in the hospital environment. Health-care leaders and managers in this study were both nursing and physician managers. Competence was assessed by evaluating the knowledge, skills, attitudes and abilities that enable management and leadership tasks. Design/methodology/approach - A systematic literature review was performed to find articles that identify and describe the characteristics of management and leadership competence...
2016: Leadership in Health Services
Xing Gao, Piotr Kuśmierczyk, Zhijun Shi, Changqing Liu, Guang Yang, Igor Sevostianov, Vadim V Silberschmidt
Biological hydrogels, e.g. bacterial cellulose (BC) hydrogel, attracted increasing interest in recent decades since they show a good potential for biomedical engineering as replacements of real tissues thanks mainly to their good biocompatibility and fibrous structure. To select potential candidates for such applications, a comprehensive understanding of their performance under application-relevant conditions is needed. Most hydrogels demonstrate time-dependent behaviour due to the contribution of their liquid phase and reorientation of fibres in a process of their deformation...
June 2016: Journal of the Mechanical Behavior of Biomedical Materials
Aris Angelis, Panos Kanavos
In recent years, multiple criteria decision analysis (MCDA) has emerged as a likely alternative to address shortcomings in health technology assessment (HTA) by offering a more holistic perspective to value assessment and acting as an alternative priority setting tool. In this paper, we argue that MCDA needs to subscribe to robust methodological processes related to the selection of objectives, criteria and attributes in order to be meaningful in the context of healthcare decision making and fulfil its role in value-based assessment (VBA)...
May 2016: PharmacoEconomics
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