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https://www.readbyqxmd.com/read/29154724/understanding-how-a-palliative-specific-patient-reported-outcome-intervention-works-to-facilitate-patient-centred-care-in-advanced-heart-failure-a-qualitative-study
#1
Pauline M Kane, Clare I Ellis-Smith, Barbara A Daveson, Karen Ryan, Niall G Mahon, Brendan McAdam, Regina McQuillan, Cecelia Tracey, Christine Howley, Geraldine O'Gara, Caroline Raleigh, Irene J Higginson, Fliss Em Murtagh, Jonathan Koffman
BACKGROUND: Palliative care needs of patients with chronic heart failure are poorly recognised. Policy makers advise a patient-centred approach to holistically assess patients' needs and care goals. Patient-reported outcome measures are proposed to facilitate patient-centred care. AIM: To explore whether and how a palliative care-specific patient-reported outcome intervention involving the Integrated Palliative care Outcome Scale influences patients' experience of patient-centred care in nurse-led chronic heart failure disease management clinics...
November 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29141643/integrative-medicine-primary-care-assessing-the-practice-model-through-patients-experiences
#2
Robert L Crocker, Amy J Grizzle, Jason T Hurwitz, Rick A Rehfeld, Ivo Abraham, Randy Horwitz, Andrew Weil, Victoria Maizes
BACKGROUND: The University of Arizona Integrative Health Center (UAIHC) was an innovative integrative medicine (IM) adult primary care clinic in Phoenix, Arizona. UAIHC used a hybrid payment model to deliver comprehensive healthcare that includes conventional and complementary medical treatments. METHODS: Fidelity measures were collected to evaluate how well the IM care delivery process matched ideals for IM. Patient experiences are presented here. Patients visiting UAIHC on 1 of 10 randomly selected days between September 2013 and February 2015 were surveyed...
November 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29096198/face-inversion-reveals-holistic-processing-of-peripheral-faces
#3
Petra Kovács, Balázs Knakker, Petra Hermann, Gyula Kovács, Zoltán Vidnyánszky
Face perception is accomplished by face-selective neural processes, involving holistic processing that enables highly efficient integration of facial features into a whole-face representation. It has been shown that in face-selective regions of the ventral temporal cortex (VTC), neural resources involved in holistic processing are primarily dedicated to the central portion of the visual field. These findings raise the intriguing possibility that holistic processing might be the privilege of centrally presented faces and could be strongly diminished in the case of peripheral faces...
October 6, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29095858/phospholipase-a2-is-involved-in-galactosylsphingosine-induced-astrocyte-toxicity-neuronal-damage-and-demyelination
#4
Cedric Misslin, Maria Velasco-Estevez, Marie Albert, Sinead A O'Sullivan, Kumlesh K Dev
Krabbe disease is a fatal rare inherited lipid storage disorder affecting 1:100,000 births. This illness is caused by mutations in the galc gene encoding for the enzyme galactosylceramidase (GALC). Dysfunction of GALC has been linked to the toxic build-up of the galactolipid, galactosylsphingosine (psychosine), which induces cell death of oligodendrocytes. Previous studies show that phospholipase A2 (PLA2) may play a role in psychosine induce cell death. Here, we demonstrate that non-selective inhibition of cPLA2/sPLA2 and selective inhibition of cPLA2, but not sPLA2, also attenuates psychosine-induced cell death of human astrocytes...
2017: PloS One
https://www.readbyqxmd.com/read/29089880/on-response-bias-in-the-face-congruency-effect-for-internal-and-external-features
#5
Günter Meinhardt, Bozana Meinhardt-Injac, Malte Persike
Some years ago Cheung et al. (2008) proposed the complete design (CD) for measuring the failure of selective attention in composite objects. Since the CD is a fully balanced design, analysis of response bias may reveal potential effects of the experimental manipulation, the stimulus material, and/or attributes of the observers. Here we used the CD to prove whether external features modulate perception of internal features with the context congruency paradigm (Nachson et al., 1995; Meinhardt-Injac et al., 2010) in a larger sample of N = 303 subjects...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29035006/applying-systems-thinking-to-inform-studies-of-wildlife-trade-in-primates
#6
Mary E Blair, Minh D Le, Hoàng M Thạch, Anna Panariello, Ngọc B Vũ, Mark G Birchette, Gautam Sethi, Eleanor J Sterling
Wildlife trade presents a major threat to primate populations, which are in demand from local to international scales for a variety of uses from food and traditional medicine to the exotic pet trade. We argue that an interdisciplinary framework to facilitate integration of socioeconomic, anthropological, and biological data across multiple spatial and temporal scales is essential to guide the study of wildlife trade dynamics and its impacts on primate populations. Here, we present a new way to design research on wildlife trade in primates using a systems thinking framework...
November 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28993490/two-sides-of-a-coin-ecological-and-chronobiological-perspectives-of-timing-in-the-wild
#7
REVIEW
Barbara Helm, Marcel E Visser, William Schwartz, Noga Kronfeld-Schor, Menno Gerkema, Theunis Piersma, Guy Bloch
Most processes within organisms, and most interactions between organisms and their environment, have distinct time profiles. The temporal coordination of such processes is crucial across levels of biological organization, but disciplines differ widely in their approaches to study timing. Such differences are accentuated between ecologists, who are centrally concerned with a holistic view of an organism in relation to its external environment, and chronobiologists, who emphasize internal timekeeping within an organism and the mechanisms of its adjustment to the environment...
November 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28941401/effect-based-assessment-of-toxicity-removal-during-wastewater-treatment
#8
Pia Välitalo, Riccardo Massei, Ilse Heiskanen, Peter Behnisch, Werner Brack, Andrew J Tindall, David Du Pasquier, Eberhard Küster, Anna Mikola, Tobias Schulze, Markus Sillanpää
Wastewaters contain complex mixtures of chemicals, which can cause adverse toxic effects in the receiving environment. In the present study, the toxicity removal during wastewater treatment at seven municipal wastewater treatment plants (WWTPs) was investigated using an effect-based approach. A battery of eight bioassays was applied comprising of cytotoxicity, genotoxicity, endocrine disruption and fish embryo toxicity assays. Human cell-based CALUX assays, transgenic larval models and the fish embryo toxicity test were particularly sensitive to WWTP effluents...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/28916329/ecological-extension-of-the-theory-of-evolution-by-natural-selection-from-a-perspective-of-western-and-eastern-holistic-philosophy
#9
REVIEW
Toshiyuki Nakajima
Evolution by natural selection requires the following conditions: (1) a particular selective environment; (2) variation of traits in the population; (3) differential survival/reproduction among the types of organisms; and (4) heritable traits. However, the traditional (standard) model does not clearly explain how and why these conditions are generated or determined. What generates a selective environment? What generates new types? How does a certain type replace, or coexist with, others? In this paper, based on the holistic philosophy of Western and Eastern traditions, I focus on the ecosystem as a higher-level system and generator of conditions that induce the evolution of component populations; I also aim to identify the ecosystem processes that generate those conditions...
September 12, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28899763/provoking-an-end-to-end-continuous-direct-compression-line-with-raw-materials-prone-to-segregation
#10
Satu Lakio, Tuomas Ervasti, Pirjo Tajarobi, Håkan Wikström, Magnus Fransson, Anssi-Pekka Karttunen, Jarkko Ketolainen, Staffan Folestad, Susanna Abrahmsén-Alami, Ossi Korhonen
Continuous manufacturing of solid oral dosage forms is promising for increasing the efficiency and quality of pharmaceutical production and products. In this study a whole train continuous direct compression (CDC) line has been provoked using challenging formulations typically prone to segregation in batch powder processing. Industrial compositions including components with variable size, bulk density and cohesive nature were selected. An experimental design, including variables such as API/mannitol particle size, API amount, powder feed rate and mixer speed, enabled the output quality of the provoked process to be assessed...
September 9, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28870009/comprehensive-analysis-of-proteomic-differences-between-escherichia-coli-k-12-and-b-strains-using-multiplexed-isobaric-tandem-mass-tag-tmt-labeling
#11
Mee-Jung Han
The Escherichia coli K-12 and B strains are among the most frequently used bacterial hosts for scientific research and biotechnological applications. However, omics analyses have revealed that E. coli K-12 and B exhibit notably different genotypic and phenotypic attributes, even though they were derived from the same ancestor. In a previous study, we identified a limited number of proteins from the two strains using two-dimensional gel electrophoresis and tandem mass spectrometry (MS/MS). In this study, an in-depth analysis of the physiological behavior of the E...
September 5, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28866575/treepod-sensitivity-aware-selection-of-pareto-optimal-decision-trees
#12
Thomas Muhlbacher, Lorenz Linhardt, Torsten Moller, Harald Piringer
Balancing accuracy gains with other objectives such as interpretability is a key challenge when building decision trees. However, this process is difficult to automate because it involves know-how about the domain as well as the purpose of the model. This paper presents TreePOD, a new approach for sensitivity-aware model selection along trade-offs. TreePOD is based on exploring a large set of candidate trees generated by sampling the parameters of tree construction algorithms. Based on this set, visualizations of quantitative and qualitative tree aspects provide a comprehensive overview of possible tree characteristics...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28859556/the-perceptions-of-first-nation-participants-in-a-community-oral-health-initiative
#13
Kavita R Mathu-Muju, James McLeod, Leeann Donnelly, Rosamund Harrison, Michael I MacEntee
The Children's Oral Health Initiative (COHI) is a federally funded community-based preventive dental program for children and their caregivers living in geographically isolated Canadian Aboriginal communities. The goal of the program is to improve access to preventive dental services for children of 0-7 years of age. It utilises community health workers in collaboration with dental therapists to promote and deliver the program. Almost half of the province of Manitoba's (n=27) First Nations communities have implemented COHI since 2005...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28858144/exploring-an-unknown-territory-sleeping-beauties-in-the-nursing-research-literature
#14
Peter Kokol, Helena Blažun Vošner, Joeri Vermeulen
BACKGROUND: Sleeping Beauties (SBs) are publications that are scarcely cited in the years immediately following publication but then suddenly become highly cited later. Such publications have unique citation patterns and can reveal important developments in the field in which they appear. OBJECTIVES: No holistic analysis of nursing SBs has been done yet. The aim of this study was to identify and analyze the SB phenomenon in the nursing research literature. METHOD: The corpus for the nursing SB identification was harvested from the Web of Science Core Collection (Thomas Reuters) for the period 1934-2015...
September 2017: Nursing Research
https://www.readbyqxmd.com/read/28742816/a-mixture-of-sparse-coding-models-explaining-properties-of-face-neurons-related-to-holistic-and-parts-based-processing
#15
Haruo Hosoya, Aapo Hyvärinen
Experimental studies have revealed evidence of both parts-based and holistic representations of objects and faces in the primate visual system. However, it is still a mystery how such seemingly contradictory types of processing can coexist within a single system. Here, we propose a novel theory called mixture of sparse coding models, inspired by the formation of category-specific subregions in the inferotemporal (IT) cortex. We developed a hierarchical network that constructed a mixture of two sparse coding submodels on top of a simple Gabor analysis...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28727993/how-do-nurse-practitioners-work-in-primary-health-care-settings-a-scoping-review
#16
REVIEW
Julian Grant, Lauren Lines, Philip Darbyshire, Yvonne Parry
OBJECTIVES: This scoping review explores the work of nurse practitioners in primary health care settings in developed countries and critiques their contribution to improved health outcomes. DESIGN: A scoping review design was employed and included development of a research question, identification of potentially relevant studies, selection of relevant studies, charting data, collating, summarising and reporting findings. An additional step was added to evaluate the methodological rigor of each study...
June 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28710639/downstream-process-synthesis-for-microbial-steroids
#17
Fabian B Thygs, Juliane Merz
Systematic and holistic process development, considering upstream and downstream processing simultaneously, is crucial for designing effective and economical production processes. Based on a multiphasic fermentation process, where oil is added to improve substrate solubility, a systematic approach for the purification of microbial steroids is presented. The design methodology incorporates expert knowledge in the form of heuristics to generate different downstream processing alternatives for processing the complex, multiphasic fermentation broth, and recovering the target steroid precursor androst-4-ene-3,17-dione (androstenedione; AD)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28691151/integrated-and-global-pseudotargeted-metabolomics-strategy-applied-to-screening-for-quality-control-markers-of-citrus-tcms
#18
Yisong Shu, Zhenli Liu, Siyu Zhao, Zhiqian Song, Dan He, Menglei Wang, Honglian Zeng, Cheng Lu, Aiping Lu, Yuanyan Liu
Traditional Chinese medicine (TCM) exerts its therapeutic effect in a holistic fashion with the synergistic function of multiple characteristic constituents. The holism philosophy of TCM is coincident with global and systematic theories of metabolomics. The proposed pseudotargeted metabolomics methodologies were employed for the establishment of reliable quality control markers for use in the screening strategy of TCMs. Pseudotargeted metabolomics integrates the advantages of both targeted and untargeted methods...
July 10, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28682298/wound-care-centers-critical-thinking-and-treatment-strategies-for-wounds
#19
Jean de Leon, Gregory A Bohn, Lawrence DiDomenico, Regina Fearmonti, H David Gottlieb, Katherine Lincoln, Jayesh B Shah, Mark Shaw, Horatio S Taveau Iv, Kerry Thibodeaux, John D Thomas, Terry A Treadwell
Many wound care centers (WCCs) provide a specialized level of care using various wound care therapies and are managed by quali ed healthcare professionals (QHPs) from di erent specialty backgrounds such as family medicine, podiatry, and plastic surgery. However, these QHPs are sometimes challenged by reimbursement issues, limited therapy and dressing options, reduced access to multidisciplinary team members, and cost-driven factors unique to WCCs. To help address these issues, a meeting was convened by an expert panel of WCC physicians to discuss best practices for treating complex patients in a WCC...
October 2016: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28651000/assessing-the-impact-of-benzo-a-pyrene-on-marine-mussels-application-of-a-novel-targeted-low-density-microarray-complementing-classical-biomarker-responses
#20
Mohamed Banni, Susanna Sforzini, Volker M Arlt, Audrey Barranger, Lorna J Dallas, Caterina Oliveri, Yann Aminot, Beniamina Pacchioni, Caterina Millino, Gerolamo Lanfranchi, James W Readman, Michael N Moore, Aldo Viarengo, Awadhesh N Jha
Despite the increasing use of mussels in environmental monitoring and ecotoxicological studies, their genomes and gene functions have not been thoroughly explored. Several cDNA microarrays were recently proposed for Mytilus spp., but putatively identified partial transcripts have rendered the generation of robust transcriptional responses difficult in terms of pathway identification. We developed a new low density oligonucleotide microarray with 465 probes covering the same number of genes. Target genes were selected to cover most of the well-known biological processes in the stress response documented over the last decade in bivalve species at the cellular and tissue levels...
2017: PloS One
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