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tDCS and Pain

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https://www.readbyqxmd.com/read/27881958/motor-cortex-neurostimulation-technologies-for-chronic-post-stroke-pain-implications-of-tissue-damage-on-stimulation-currents
#1
Anthony T O'Brien, Rivadavio Amorim, R Jarrett Rushmore, Uri Eden, Linda Afifi, Laura Dipietro, Timothy Wagner, Antoni Valero-Cabré
Background: Central post stroke pain (CPSP) is a highly refractory syndrome that can occur after stroke. Primary motor cortex (M1) brain stimulation using epidural brain stimulation (EBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS) have been explored as potential therapies for CPSP. These techniques have demonstrated variable clinical efficacy. It is hypothesized that changes in the stimulating currents that are caused by stroke-induced changes in brain tissue conductivity limit the efficacy of these techniques...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27869996/efficacy-of-noninvasive-brain-stimulation-on-pain-control-in-migraine-patients-a-systematic-review-and-meta-analysis
#2
REVIEW
Lívia Shirahige, Lorena Melo, Fernanda Nogueira, Sérgio Rocha, Kátia Monte-Silva
OBJECTIVE: To evaluate the efficacy of noninvasive brain stimulation (NIBS) on pain control in migraine patients. BACKGROUND: Recent studies have used NIBS as an abortive and prophylactic treatment for migraine; however, its efficacy regarding meaningful clinical effects remains to be critically analyzed. DESIGN: Systematic review of controlled clinical trials. METHODS: Searches were conducted in six databases: MEDLINE (via PubMed), LILACS (via BIREME), CINAHL (via EBSCO), Scopus (via EBSCO), Web of Science, and CENTRAL...
November 2016: Headache
https://www.readbyqxmd.com/read/27866120/evidence-based-guidelines-on-the-therapeutic-use-of-transcranial-direct-current-stimulation-tdcs
#3
REVIEW
Jean-Pascal Lefaucheur, Andrea Antal, Samar S Ayache, David H Benninger, Jérôme Brunelin, Filippo Cogiamanian, Maria Cotelli, Dirk De Ridder, Roberta Ferrucci, Berthold Langguth, Paola Marangolo, Veit Mylius, Michael A Nitsche, Frank Padberg, Ulrich Palm, Emmanuel Poulet, Alberto Priori, Simone Rossi, Martin Schecklmann, Sven Vanneste, Ulf Ziemann, Luis Garcia-Larrea, Walter Paulus
A group of European experts was commissioned by the European Chapter of the International Federation of Clinical Neurophysiology to gather knowledge about the state of the art of the therapeutic use of transcranial direct current stimulation (tDCS) from studies published up until September 2016, regarding pain, Parkinson's disease, other movement disorders, motor stroke, poststroke aphasia, multiple sclerosis, epilepsy, consciousness disorders, Alzheimer's disease, tinnitus, depression, schizophrenia, and craving/addiction...
October 29, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27865707/a-comprehensive-database-of-published-tdcs-clinical-trials-2005-2016
#4
REVIEW
Jean-Pascal Lefaucheur
Transcranial direct current stimulation (tDCS) is a technique of noninvasive cortical stimulation allowing significant modification of brain functions. Clinical application of this technique was reported for the first time in March 2005. This paper presents a detailed list of the 340 articles (excluding single case reports) which have assessed the clinical effect of tDCS in patients, at least when delivered to cortical targets. The reviewed conditions were: pain syndromes, Parkinson's disease, dystonia, cerebral palsy, post-stroke limb motor impairment, post-stroke neglect, post-stroke dysphagia, post-stroke aphasia, primary progressive aphasia, multiple sclerosis, epilepsy, consciousness disorders, Alzheimer's disease and other types of dementia, tinnitus, depression, auditory hallucinations and negative symptoms of schizophrenia, addiction and craving, autism, and attention disorders...
December 2016: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/27765610/neural-signature-of-tdcs-tpcs-and-their-combination-comparing-the-effects-on-neural-plasticity
#5
Thibaut Aurore, Russo Cristina, Morales-Quezada Leon, Hurtado-Puerto Aura, Deitos Alícia, Steven Freedman, Carvalho Sandra, Fregni Felipe
Transcranial pulsed current stimulation (tPCS) and transcranial direct current stimulation (tDCS) are two noninvasive neuromodulatory brain stimulation techniques whose effects on human brain and behavior have been studied individually. In the present study we aimed to quantify the effects of tDCS and tPCS, individually and in combination, on cortical activity, sensitivity and pain-related assessments in healthy individuals in order to understand their neurophysiological mechanisms and potential applications in clinical populations...
October 17, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27751960/transcranial-direct-current-stimulation-improves-isometric-time-to-exhaustion-of-the-knee-extensors
#6
L Angius, B Pageaux, J Hopker, S M Marcora, A R Mauger
Transcranial direct current stimulation (tDCS) can increase cortical excitability of a targeted brain area, which may affect endurance exercise performance. However, optimal electrode placement for tDCS remains unclear. We tested the effect of two different tDCS electrode montages for improving exercise performance. Nine subjects underwent a control (CON), placebo (SHAM) and two different tDCS montage sessions in a randomized design. In one tDCS session, the anodal electrode was placed over the left motor cortex and the cathodal on contralateral forehead (HEAD), while for the other montage the anodal electrode was placed over the left motor cortex and cathodal electrode above the shoulder (SHOULDER)...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27729853/feasibility-of-non-invasive-brain-modulation-for-management-of-pain-related-to-chemoradiotherapy-in-patients-with-advanced-head-and-neck-cancer
#7
Xiao-Su Hu, Clayton A Fisher, Stephanie M Munz, Rebecca L Toback, Thiago D Nascimento, Emily L Bellile, Laura Rozek, Avraham Eisbruch, Francis P Worden, Theodora E Danciu, Alexandre F DaSilva
Patients with head and neck cancer often experience a significant decrease in their quality of life during chemoradiotherapy (CRT) due to treatment-related pain, which is frequently classified as severe. Transcranial direct current stimulation (tDCS) is a method of non-invasive brain stimulation that has been frequently used in experimental and clinical pain studies. In this pilot study, we investigated the clinical impact and central mechanisms of twenty primary motor cortex (M1) stimulation sessions with tDCS during 7 weeks of CRT for head and neck cancer...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27693941/animal-models-of-transcranial-direct-current-stimulation-methods-and-mechanisms
#8
REVIEW
Mark P Jackson, Asif Rahman, Belen Lafon, Gregory Kronberg, Doris Ling, Lucas C Parra, Marom Bikson
The objective of this review is to summarize the contribution of animal research using direct current stimulation (DCS) to our understanding of the physiological effects of transcranial direct current stimulation (tDCS). We comprehensively address experimental methodology in animal studies, broadly classified as: (1) transcranial stimulation; (2) direct cortical stimulation in vivo and (3) in vitro models. In each case advantages and disadvantages for translational research are discussed including dose translation and the overarching "quasi-uniform" assumption, which underpins translational relevance in all animal models of tDCS...
November 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27677678/application-and-outcomes-of-therapy-combining-transcranial-direct-current-stimulation-and-virtual-reality-a-systematic-review
#9
Thais Massetti, Tânia Brusque Crocetta, Talita Dias da Silva, Isabela Lopes Trevizan, Claudia Arab, Fátima Aparecida Caromano, Carlos Bandeira de Mello Monteiro
PURPOSE: To evaluate the methods and major outcomes of transcranial direct current stimulation (tDCS) combined with virtual reality (VR) therapy in randomized controlled trials. METHOD: A systematic review was performed following PRISMA guidelines using PubMed, PubMed Central, Web of Science and CAPES periodic databases, with no time restriction. The studies were screened for the following inclusion criteria: human subjects, combination of VR and tDCS methods, and randomized controlled study design...
September 27, 2016: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/27615184/-transcranial-direct-current-stimulation-new-clinical-roadmaps-for-psychiatric-research
#10
Alexandre Heeren, Charlotte Coussement, Élisabeth Colon
Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that has undergone intensive research over the past decade with promising results. tDCS is based on the application of weak, direct current over the scalp, leading to cortical hypo- or hyperpolarization according to the specified parameters. Recent studies have shown that tDCS is able to induce potent changes in cortical excitability as well as to elicit long-lasting modifications in brain activity. Over the last decade, tDCS physiological mechanisms of action have been intensively investigated...
August 2016: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/27511815/ean-guidelines-on-central-neurostimulation-therapy-in-chronic-pain-conditions
#11
G Cruccu, L Garcia-Larrea, P Hansson, M Keindl, J-P Lefaucheur, W Paulus, R Taylor, V Tronnier, A Truini, N Attal
BACKGROUND AND PURPOSE: Our aim was to update previous European Federation of Neurological Societies guidelines on neurostimulation for neuropathic pain, expanding the search to new techniques and to chronic pain conditions other than neuropathic pain, and assessing the evidence with the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system. METHODS: A systematic review and meta-analysis of trials published between 2006 and December 2014 was conducted...
October 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27383993/optimizing-rehabilitation-for-phantom-limb-pain-using-mirror-therapy-and-transcranial-direct-current-stimulation-a-randomized-double-blind-clinical-trial-study-protocol
#12
Camila Bonin Pinto, Faddi Ghassan Saleh Velez, Nadia Bolognini, David Crandell, Lotfi B Merabet, Felipe Fregni
BACKGROUND: Despite the multiple available pharmacological and behavioral therapies for the management of chronic phantom limb pain (PLP) in lower limb amputees, treatment for this condition is still a major challenge and the results are mixed. Given that PLP is associated with maladaptive brain plasticity, interventions that promote cortical reorganization such as non-invasive brain stimulation and behavioral methods including transcranial direct current stimulation (tDCS) and mirror therapy (MT), respectively, may prove to be beneficial to control pain in PLP...
2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27208831/effects-of-left-primary-motor-and-dorsolateral-prefrontal-cortex-transcranial-direct-current-stimulation-on-laser-evoked-potentials-in-migraine-patients-and-normal-subjects
#13
Eleonora Vecchio, Katia Ricci, Anna Montemurno, Marianna Delussi, Sara Invitto, Marina de Tommaso
Migraine is characterized by an altered cortical excitability. Because transcranial direct current stimulation (tDCS) can change brain activity noninvasively, it is possible to hypothesize its efficacy in modulating pain in migraine. In this study, we compared the effects of tDCS of the left primary motor cortex (M1) and left dorsolateral prefrontal cortex (DLPFC) both on subjective pain and on evoked responses induced by laser stimulation (LEPs). Thirty-two patients and sixteen controls were randomized to receive sham stimulation and real tDCS with the anode centered over M1 or DLPFC...
July 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27190485/the-antalgic-effects-of-non-invasive-physical-modalities-on-central-post-stroke-pain-a-systematic-review
#14
Chih-Chung Chen, Yu-Fen Chuang, Andrew Chih-Wei Huang, Chih-Kuang Chen, Ya-Ju Chang
[Purpose] This study systematically reviewed the antalgic effects of non-invasive physical modalities (NIPMs) on central post-stroke pain (CPSP). [Subjects and Methods] Clinical studies were sought on September 2015 in 10 electronic databases, including Medline and Scopus. The searching strings were "central pain and stroke" and "treatment, and physical or non-pharmacological". The inclusion and exclusion criteria were set for screening the clinical articles by two reviewers. Pain scores on visual analog scale in an article were used as the outcome measure for resulting judgment...
April 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27179944/efficacy-of-transcranial-direct-current-stimulation-tdcs-in-women-with-provoked-vestibulodynia-study-protocol-for-a-randomized-controlled-trial
#15
Annie Morin, Guillaume Léonard, Véronique Gougeon, Guy Waddell, Yves-André Bureau, Isabelle Girard, Mélanie Morin
BACKGROUND: Provoked vestibulodynia is the most common form of vulvodynia. Despite its high prevalence and deleterious sexual, conjugal, and psychological repercussions, effective evidence-based interventions for provoked vestibulodynia remain limited. For a high proportion of women, significant pain persists despite the currently available treatments. Growing evidence suggests that the central nervous system (CNS) could play a key role in provoked vestibulodynia; thus, treatment targeting the CNS, rather than localized dysfunctions, may be beneficial for women suffering from provoked vestibulodynia...
2016: Trials
https://www.readbyqxmd.com/read/27150193/the-effects-of-add-on-non-invasive-brain-stimulation-in-fibromyalgia-a-meta-analysis-and-meta-regression-of-randomized-controlled-trials
#16
Wen-Hsuan Hou, Tzu-Ya Wang, Jiunn-Horng Kang
OBJECTIVES: The effects of non-invasive brain stimulation (NBS), including repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (TDCS), in treating FM remain inconclusive. The aim of this study was to investigate present evidence of using NBS as an add-on treatment in treating FM. METHODS: We conducted a database search of the Medline, Embase, PsycINFO and Cochrane Library electronic databases, from inception to July 2015, to analyse randomized controlled trials of NBS in treating FM...
August 2016: Rheumatology
https://www.readbyqxmd.com/read/27148019/brain-stimulation-therapy-for-central-post-stroke-pain-from-a-perspective-of-interhemispheric-neural-network-remodeling
#17
Takashi Morishita, Tooru Inoue
Central post-stroke pain (CPSP) is a debilitating, severe disorder affecting patient quality of life. Since CPSP is refractory to medication, various treatment modalities have been tried with marginal results. Following the first report of epidural motor cortex (M1) stimulation (MCS) for CPSP, many researchers have investigated the mechanisms of electrical stimulation of the M1. CPSP is currently considered to be a maladapted network reorganization problem following stroke, and recent studies have revealed that the activities of the impaired hemisphere after stroke may be inhibited by the contralesional hemisphere...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27092048/prefrontal-tdcs-decreases-pain-in-patients-with-multiple-sclerosis
#18
Samar S Ayache, Ulrich Palm, Moussa A Chalah, Tarik Al-Ani, Arnaud Brignol, Mohamed Abdellaoui, Dalia Dimitri, Marc Sorel, Alain Créange, Jean-Pascal Lefaucheur
BACKGROUND: In the last few years, transcranial direct current stimulation (tDCS) has emerged as an appealing therapeutic option to improve brain functions. Promising data support the role of prefrontal tDCS in augmenting cognitive performance and ameliorating several neuropsychiatric symptoms, namely pain, fatigue, mood disturbances, and attentional impairment. Such symptoms are commonly encountered in patients with multiple sclerosis (MS). OBJECTIVE: The main objective of the current work was to evaluate the tDCS effects over the left dorsolateral prefrontal cortex (DLPFC) on pain in MS patients...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27071073/top-down-effect-of-direct-current-stimulation-on-the-nociceptive-response-of-rats
#19
Luiz Fabio Dimov, Adriano Cardozo Franciosi, Ana Carolina Pinheiro Campos, André Russowsky Brunoni, Rosana Lima Pagano
Transcranial direct current stimulation (tDCS) is an emerging, noninvasive technique of neurostimulation for treating pain. However, the mechanisms and pathways involved in its analgesic effects are poorly understood. Therefore, we investigated the effects of direct current stimulation (DCS) on thermal and mechanical nociceptive thresholds and on the activation of the midbrain periaqueductal gray (PAG) and the dorsal horn of the spinal cord (DHSC) in rats; these central nervous system areas are associated with pain processing...
2016: PloS One
https://www.readbyqxmd.com/read/27044999/the-heart-side-of-brain-neuromodulation
#20
REVIEW
Simone Rossi, Emiliano Santarnecchi, Gaetano Valenza, Monica Ulivelli
Neuromodulation refers to invasive, minimally invasive or non-invasive techniques to stimulate discrete cortical or subcortical brain regions with therapeutic purposes in otherwise intractable patients: for example, thousands of advanced Parkinsonian patients, as well as patients with tremor or dystonia, benefited by deep brain stimulation (DBS) procedures (neural targets: basal ganglia nuclei). A new era for DBS is currently opening for patients with drug-resistant depression, obsessive-compulsive disorders, severe epilepsy, migraine and chronic pain (neural targets: basal ganglia and other subcortical nuclei or associative fibres)...
May 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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