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tDCS and Pain

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https://www.readbyqxmd.com/read/28419862/the-effect-of-tdcs-over-the-right-temporo-parietal-junction-on-pain-empathy
#1
Michel-Pierre Coll, Marie-Pier B Tremblay, Philip L Jackson
Empathy is a complex psychological phenomenon crucial for social perception and interactions. Several lines of evidence suggest that the right temporo-parietal junction is involved in self-other control mechanisms that play an important role in empathic responses. However, limited direct evidence of the involvement of this region in empathic responses is currently available. In this study, inhibitory transcranial direct current stimulation over this region influenced empathic responses to others' pain. It was found that compared to participants that received anodal or sham transcranial direct current stimulation, participants who received cathodal transcranial direct current stimulation over the right temporo-parietal junction perceived the pain of others as less intense compared to sham stimulation and showed decreased late event related potentials to facial expressions of pain...
April 15, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28321566/differential-effects-of-bifrontal-and-occipital-nerve-stimulation-on-pain-and-fatigue-using-transcranial-direct-current-stimulation-in-fibromyalgia-patients
#2
Wing Ting To, Evan James, Jan Ost, John Hart, Dirk De Ridder, Sven Vanneste
Fibromyalgia is a disorder characterized by widespread musculoskeletal pain frequently accompanied by other symptoms such as fatigue. Moderate improvement from pharmacological and non-pharmacological treatments have proposed non-invasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) to the occipital nerve (more specifically the C2 area) or to the dorsolateral prefrontal cortex (DLPFC) as potential treatments. We aimed to explore the effectiveness of repeated sessions of tDCS (eight sessions) targeting the C2 area and DLPFC in reducing fibromyalgia symptoms, more specifically pain and fatigue...
March 20, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28302387/efficacy-of-transcranial-direct-current-stimulation-in-women-with-provoked-vestibulodynia
#3
Annie Morin, Guillaume Léonard, Véronique Gougeon, Marie-Pierre Cyr, Guy Waddell, Yves-André Bureau, Isabelle Girard, Mélanie Morin
BACKGROUND: Provoked vestibulodynia is a highly prevalent condition characterized by acute recurrent pain located at the vaginal entrance in response to pressure application or attempted vaginal penetration. Despite a wide variety of treatments offered to women with provoked vestibulodynia, a high proportion of women are refractory to conventional treatment. Transcranial direct-current stimulation is a noninvasive brain stimulation technique that has been shown effective for improving various chronic pain conditions...
March 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28299412/tdcs-application-over-the-stg-improves-the-ability-to-recognize-and-appreciate-elements-involved-in-humor-processing
#4
Mirella Manfredi, Alice Mado Proverbio, Ana Paula Gonçalves Donate, Sofia Macarini Gonçalves Vieira, William Edgar Comfort, Mariana De Araújo Andreoli, Paulo Sérgio Boggio
The superior temporal gyrus (STG) has been found to play a crucial role in the recognition of actions and facial expressions and may, therefore, be critical for the processing of humorous information. Here we investigated whether tDCS application to the STG would modulate the ability to recognize and appreciate the comic element in serious and comedic situations of misfortune. To this aim, the effects of different types of tDCS stimulation on the STG were analyzed during a task in which the participants were instructed to categorize various misfortunate situations as "comic" or "not comic"...
March 15, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28273933/anodal-transcranial-direct-current-stimulation-over-the-left-dorsolateral-prefrontal-cortex-modulates-attention-and-pain-in-fibromyalgia-randomized-clinical-trial
#5
Adriana Ferreira Silva, Maxciel Zortea, Sandra Carvalho, Jorge Leite, Iraci Lucena da Silva Torres, Felipe Fregni, Wolnei Caumo
Cognitive dysfunction in fibromyalgia patients has been reported, especially when increased attentional demands are required. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in modulating attention. We tested the effects of a single session of tDCS coupled with a Go/No-go task in modulating three distinct attentional networks: alertness, orienting and executive control. Secondarily, the effect on pain measures was evaluated. Forty females with fibromyalgia were randomized to receive active or sham tDCS...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28265507/the-effects-of-elevated-pain-inhibition-on-endurance-exercise-performance
#6
Andrew Flood, Gordon Waddington, Richard J Keegan, Kevin G Thompson, Stuart Cathcart
BACKGROUND: The ergogenic effects of analgesic substances suggest that pain perception is an important regulator of work-rate during fatiguing exercise. Recent research has shown that endogenous inhibitory responses, which act to attenuate nociceptive input and reduce perceived pain, can be increased following transcranial direct current stimulation of the hand motor cortex. Using high-definition transcranial direct current stimulation (HD-tDCS; 2 mA, 20 min), the current study aimed to examine the effects of elevated pain inhibitory capacity on endurance exercise performance...
2017: PeerJ
https://www.readbyqxmd.com/read/28231681/noninvasive-transcranial-direct-current-stimulation-tdcs-for-the-treatment-of-orofacial-pain
#7
Jitka Fricova, Katerina Englerova, Richard Rokyta
OBJECTIVE: tDCS is a promising method for the treatment of chronic pain. Electrode placement locations must be chosen in accordance with the density and the time course of the current in order to prevent pathological changes in the underlying tissue. In order to reduce current spatial variability, more electrodes of the same polarity are placed in a circle around the second electrode of the opposite polarity. The applied current produced the greatest changes directly beneath the electrodes: the cathode reduces the excitability of cortical neurons, while the anode has the opposite effect...
October 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28222543/anodal-cerebellar-tdcs-modulates-lower-extremity-pain-perception
#8
Manuel Pereira, Basil Rafiq, Einul Chowdhury, Jacqueline Babayev, HyunJi Boo, Rowan Metwaly, Priam Sandilya, Eileen Chusid, Fortunato Battaglia
BACKGROUND: Previous studies have investigated the use of transcranial direct current stimulation (tDCS) for pain management. The studies investigating therapeutic neuromodulation with tDCS for lower extremity pain are scarce and inconclusive. OBJECTIVE: The aim of the present study was to analyze the effects of cerebellar tDCS on lower extremity sensory and pain thresholds in healthy volunteers. METHODS: This was a single-blind crossover repeated-measure study...
2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28208601/surgical-neurostimulation-for-spinal-cord-injury
#9
REVIEW
Aswin Chari, Ian D Hentall, Marios C Papadopoulos, Erlick A C Pereira
Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI...
February 10, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28148969/structural-connectivity-variances-underlie-functional-and-behavioral-changes-during-pain-relief-induced-by-neuromodulation
#10
Richard L Lin, Gwenaëlle Douaud, Nicola Filippini, Thomas W Okell, Charlotte J Stagg, Irene Tracey
An increased understanding of the relationship between structural connections and functional and behavioral outcomes is an essential but under-explored topic in neuroscience. During transcranial direct current stimulation (tDCS)-induced analgesia, neuromodulation occurs through a top-down process that depends on inter-regional connections. To investigate whether variation in anatomical connectivity explains functional and behavorial outcomes during neuromodulation, we first combined tDCS and a tonic pain model with concurrent arterial spin labelling that measures cerebral perfusion related to ongoing neural activity...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28142257/transcranial-direct-current-stimulation-targeting-primary-motor-versus-dorsolateral-prefrontal-cortices-proof-of-concept-study-investigating-functional-connectivity-of-thalamocortical-networks-specific-to-sensory-affective-information-processing
#11
Vishwanath Sankarasubramanian, David A Cunningham, Kelsey A Potter-Baker, Erik B Beall, Sarah M Roelle, Nicole M Varnerin, Andre G Machado, Stephen E Jones, Mark J Lowe, Ela B Plow
The pain matrix is comprised of an extensive network of brain structures involved in sensory and/or affective information processing. The thalamus is a key structure constituting the pain matrix. The thalamus serves as a relay center receiving information from multiple ascending pathways and relating information to and from multiple cortical areas. However, it is unknown how thalamocortical networks specific to sensory-affective information processing are functionally integrated. Here, in a proof-of-concept study in healthy humans, we aimed to understand this connectivity using transcranial direct current stimulation (tDCS) targeting primary motor (M1) or dorsolateral prefrontal cortices (DLPFC)...
April 2017: Brain Connectivity
https://www.readbyqxmd.com/read/28039022/a-study-protocol-for-a-single-blind-randomized-controlled-trial-of-adjunctive-transcranial-direct-current-stimulation-tdcs-for-chronic-pain-among-patients-receiving-specialized-inpatient-multimodal-pain-management
#12
G Janice Jimenez-Torres, Benjamin L Weinstein, Cory R Walker, J Christopher Fowler, Philippa Ashford, Jeffrey J Borckardt, Alok Madan
BACKGROUND: Available treatments for chronic pain (CP) are modestly effective or associated with iatrogenic harm. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that may be an effective, adjunctive treatment to non-opioid therapies. In this randomized control trial (RCT), we compare adjunctive active versus sham tDCS among patients in a multimodal inpatient pain management program. The primary objectives of the RCT are to improve pain tolerance and subjective pain experience...
March 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28004273/occipital-nerve-field-transcranial-direct-current-stimulation-normalizes-imbalance-between-pain-detecting-and-pain-inhibitory-pathways-in-fibromyalgia
#13
Dirk De Ridder, Sven Vanneste
Occipital nerve field (OCF) stimulation with subcutaneously implanted electrodes is used to treat headaches, more generalized pain, and even failed back surgery syndrome via unknown mechanisms. Transcranial direct current stimulation (tDCS) can predict the efficacy of implanted electrodes. The purpose of this study is to unravel the neural mechanisms involved in global pain suppression, mediated by occipital nerve field stimulation, within the realm of fibromyalgia. Nineteen patients with fibromyalgia underwent a placebo-controlled OCF tDCS...
December 21, 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27984542/transcranial-direct-current-stimulation-over-the-opercular-somatosensory-region-does-not-influence-experimentally-induced-pain-a-triple-blind-sham-controlled-study
#14
Soichiro Koyama, Kei Nakagawa, Satoshi Tanaka
Transcranial magnetic stimulation (TMS) over the opercular somatosensory region (OP), which includes the secondary somatosensory cortex and the insular cortex, suppresses pain sensation. However, whether transcranial direct current stimulation (tDCS) over the OP has a similar effect on pain sensation remains unknown. We examined whether pain sensation would be suppressed by tDCS over the OP. Our experiment with a triple-blind, sham-controlled, crossover design involved 12 healthy participants. Participants were asked to rate their subjective pain intensity during and after three types of bihemispheric tDCS: right anodal/left cathodal OP tDCS, left anodal/right cathodal OP tDCS (2 mA, 12 min), and sham tDCS (15 s)...
February 8, 2017: Neuroreport
https://www.readbyqxmd.com/read/27881958/motor-cortex-neurostimulation-technologies-for-chronic-post-stroke-pain-implications-of-tissue-damage-on-stimulation-currents
#15
Anthony T O'Brien, Rivadavio Amorim, R Jarrett Rushmore, Uri Eden, Linda Afifi, Laura Dipietro, Timothy Wagner, Antoni Valero-Cabré
Background: Central post stroke pain (CPSP) is a highly refractory syndrome that can occur after stroke. Primary motor cortex (M1) brain stimulation using epidural brain stimulation (EBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS) have been explored as potential therapies for CPSP. These techniques have demonstrated variable clinical efficacy. It is hypothesized that changes in the stimulating currents that are caused by stroke-induced changes in brain tissue conductivity limit the efficacy of these techniques...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27869996/efficacy-of-noninvasive-brain-stimulation-on-pain-control-in-migraine-patients-a-systematic-review-and-meta-analysis
#16
REVIEW
Lívia Shirahige, Lorena Melo, Fernanda Nogueira, Sérgio Rocha, Kátia Monte-Silva
OBJECTIVE: To evaluate the efficacy of noninvasive brain stimulation (NIBS) on pain control in migraine patients. BACKGROUND: Recent studies have used NIBS as an abortive and prophylactic treatment for migraine; however, its efficacy regarding meaningful clinical effects remains to be critically analyzed. DESIGN: Systematic review of controlled clinical trials. METHODS: Searches were conducted in six databases: MEDLINE (via PubMed), LILACS (via BIREME), CINAHL (via EBSCO), Scopus (via EBSCO), Web of Science, and CENTRAL...
November 2016: Headache
https://www.readbyqxmd.com/read/27866120/evidence-based-guidelines-on-the-therapeutic-use-of-transcranial-direct-current-stimulation-tdcs
#17
REVIEW
Jean-Pascal Lefaucheur, Andrea Antal, Samar S Ayache, David H Benninger, Jérôme Brunelin, Filippo Cogiamanian, Maria Cotelli, Dirk De Ridder, Roberta Ferrucci, Berthold Langguth, Paola Marangolo, Veit Mylius, Michael A Nitsche, Frank Padberg, Ulrich Palm, Emmanuel Poulet, Alberto Priori, Simone Rossi, Martin Schecklmann, Sven Vanneste, Ulf Ziemann, Luis Garcia-Larrea, Walter Paulus
A group of European experts was commissioned by the European Chapter of the International Federation of Clinical Neurophysiology to gather knowledge about the state of the art of the therapeutic use of transcranial direct current stimulation (tDCS) from studies published up until September 2016, regarding pain, Parkinson's disease, other movement disorders, motor stroke, poststroke aphasia, multiple sclerosis, epilepsy, consciousness disorders, Alzheimer's disease, tinnitus, depression, schizophrenia, and craving/addiction...
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27865707/a-comprehensive-database-of-published-tdcs-clinical-trials-2005-2016
#18
REVIEW
Jean-Pascal Lefaucheur
Transcranial direct current stimulation (tDCS) is a technique of noninvasive cortical stimulation allowing significant modification of brain functions. Clinical application of this technique was reported for the first time in March 2005. This paper presents a detailed list of the 340 articles (excluding single case reports) which have assessed the clinical effect of tDCS in patients, at least when delivered to cortical targets. The reviewed conditions were: pain syndromes, Parkinson's disease, dystonia, cerebral palsy, post-stroke limb motor impairment, post-stroke neglect, post-stroke dysphagia, post-stroke aphasia, primary progressive aphasia, multiple sclerosis, epilepsy, consciousness disorders, Alzheimer's disease and other types of dementia, tinnitus, depression, auditory hallucinations and negative symptoms of schizophrenia, addiction and craving, autism, and attention disorders...
December 2016: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/27765610/neural-signature-of-tdcs-tpcs-and-their-combination-comparing-the-effects-on-neural-plasticity
#19
Aurore Thibaut, Cristina Russo, Leon Morales-Quezada, Aura Hurtado-Puerto, Alícia Deitos, Steven Freedman, Sandra Carvalho, Felipe Fregni
Transcranial pulsed current stimulation (tPCS) and transcranial direct current stimulation (tDCS) are two noninvasive neuromodulatory brain stimulation techniques whose effects on human brain and behavior have been studied individually. In the present study we aimed to quantify the effects of tDCS and tPCS, individually and in combination, on cortical activity, sensitivity and pain-related assessments in healthy individuals in order to understand their neurophysiological mechanisms and potential applications in clinical populations...
January 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27751960/transcranial-direct-current-stimulation-improves-isometric-time-to-exhaustion-of-the-knee-extensors
#20
L Angius, B Pageaux, J Hopker, S M Marcora, A R Mauger
Transcranial direct current stimulation (tDCS) can increase cortical excitability of a targeted brain area, which may affect endurance exercise performance. However, optimal electrode placement for tDCS remains unclear. We tested the effect of two different tDCS electrode montages for improving exercise performance. Nine subjects underwent a control (CON), placebo (SHAM) and two different tDCS montage sessions in a randomized design. In one tDCS session, the anodal electrode was placed over the left motor cortex and the cathodal on contralateral forehead (HEAD), while for the other montage the anodal electrode was placed over the left motor cortex and cathodal electrode above the shoulder (SHOULDER)...
December 17, 2016: Neuroscience
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