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tDCS and Pain

Chong Liao, Song Wu, Yue-Jia Luo, Qing Guan, Fang Cui
Social decision-making engages traditional decision-making processes (e.g. valuation), as well as social cognition processes (e.g. inferring the affective and mental states of another person). Neuroimaging and neuro-stimulation studies have suggested the involvement of the medial prefrontal cortex (mPFC) in a variety of social decision-making tasks. Yet no study has investigated the effect of the cortical excitability of mPFC in the decision-making of costly helping behavior. Here, we used tDCS to demonstrate the causal relationship between the cortical excitability of mPFC and costly helping decision-making...
March 14, 2018: Neuroscience Letters
Neil E O'Connell, Louise Marston, Sally Spencer, Lorraine H DeSouza, Benedict M Wand
BACKGROUND: This is an updated version of the original Cochrane Review published in 2010, Issue 9, and last updated in 2014, Issue 4. Non-invasive brain stimulation techniques aim to induce an electrical stimulation of the brain in an attempt to reduce chronic pain by directly altering brain activity. They include repetitive transcranial magnetic stimulation (rTMS), cranial electrotherapy stimulation (CES), transcranial direct current stimulation (tDCS), transcranial random noise stimulation (tRNS) and reduced impedance non-invasive cortical electrostimulation (RINCE)...
March 16, 2018: Cochrane Database of Systematic Reviews
C Kornreich, P Cole, H Kajosch
Transcranial Direct Current Stimulation (tDCS) is a cheap, easy to use, and relatively safe noninvasive brain stimulation technique. It is increasingly used in several indications in psychiatry and neurology, mainly for depression, chronic pain and cognitive decline due to degenerative brain diseases. Its efficacy is probable in depression and must still be confirmed in numerous other indications. Lowcost devices for the general public are easy to find on the internet and are frequently used for non-therapeutic indications, like the improvement of video gamers' performances...
2018: Revue Médicale de Bruxelles
Gilberto Braulio, Savio C Passos, Fabricio Leite, Andre Schwertner, Luciana C Stefani, Ana C S Palmer, Iraci L S Torres, Felipe Fregni, Wolnei Caumo
Background: Remifentanil-induced hyperalgesia (r-IH) involves an imbalance in the inhibitory and excitatory systems. As the transcranial Direct Current Stimulation (tDCS) modulates the thalamocortical synapses in a top-down manner, we hypothesized that the active (a)-t-DCS would be more effective than sham(s)-tDCS to prevent r-IH. We used an experimental paradigm to induce temporal summation of pain utilizing a repetitive cold test (rCOLDT) assessed by the Numerical Pain Score (NPS 0-10) and we evaluated the function of the descending pain modulatory system (DPMS) by the change on the NPS (0-10) during the conditioned pain modulation (CPM)-task (primary outcomes)...
2018: Frontiers in Pharmacology
Tribikram Thapa, Thomas Graven-Nielsen, Lucinda S Chipchase, Siobhan M Schabrun
OBJECTIVE: Homeostatic plasticity mechanisms regulate synaptic plasticity in the human brain. Impaired homeostatic plasticity may contribute to maladaptive synaptic plasticity and symptom persistence in chronic musculoskeletal pain. METHODS: We examined homeostatic plasticity in fifty individuals with chronic low back pain (cLBP) and twenty-five pain-free controls. A single block (7-min) of anodal transcranial direct current stimulation ('single tDCS'), or two subsequent blocks (7-min and 5-min separated by 3-min rest; 'double tDCS'), were randomised across two experimental sessions to confirm an excitatory response to tDCS applied alone, and evaluate homeostatic plasticity, respectively...
February 9, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Zoha Deldar, Nabi Rustamov, Suzie Bois, Isabelle Blanchette, Mathieu Piché
The aim of this study was to examine whether transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) enhances pain inhibition by improving working memory (WM). Forty healthy volunteers participated in two tDCS sessions. Pain was evoked by electrical stimulation at the ankle. Participants performed an n-back task (0-back and 2-back). The experimental protocol comprised five counterbalanced conditions (0-back, 2-back, pain, 0-back with pain and 2-back with pain) that were performed twice (pre-tDCS baseline and during tDCS)...
February 15, 2018: Journal of Physiological Sciences: JPS
Andressa de Souza, Daniel F Martins, Liciane Fernandes Medeiros, Catharina Nucci, Thiago César Martins, Aline Siteneski, Wolnei Caumo, Adair Roberto Soares Dos Santos, Iraci L S Torres
BACKGROUND: Neuropathic pain is relatively common and occurs in approximately 6-8% of the population. It is associated with allodynia and hyperalgesia. Thus, non-pharmacological treatments, such as transcranial direct current stimulation (tDCS) may be useful for relieving pain. OBJECTIVES: This study aimed to investigate the antiallodynic effect of tDCS in a mice model of neuropathic pain, and the underlying neurotransmission systems that could drive these effects...
December 21, 2017: Brain Research
Sandra Carvalho, Jorge Leite, Felipe Jones, Leslie R Morse, Ross Zafonte, Felipe Fregni
STUDY DESIGN: Secondary analysis of a clinical trial. OBJECTIVES: To analyze adherence to 1-year transcranial Direct Current Stimulation (tDCS) clinical trial in people with chronic pain due to spinal cord injury (SCI). We also explore the association between dropout and several baseline variables such as age, depression levels, pain severity, number of days with pain in the last 7 days, walking ability, sleep, work, relationship with others, and enjoyment with life...
December 13, 2017: Spinal Cord
Aline Iannone, Joaquim Brasil-Neto, Antonio Pedro Mello Cruz, Corina Satler, Nasser Allam
Although growing evidence points to the potential therapeutic effects of transcranial Direct Current Stimulation (tDCS), there is still no consensus on the most appropriate protocol to be used in specific neurological and neuropsychological symptoms. This case report evaluated the neuromodulatory therapeutic effects of two 15-day courses of tDCS on an elderly female patient, aged 78 years with mild neurocognitive disorder, chronic pain and depression-related symptoms. Results indicated an overall significant improvement of cognitive and executive functions, as well as reduction in both depression and chronic pain symptoms...
July 2017: Dementia & Neuropsychologia
Hugo Ribeiro, Ricardo Bertol Sesterhenn, Andressa de Souza, Ana Claudia de Souza, Monique Alves, Jessica Catarina Machado, Nathalia Bofill Burger, Iraci Lucena da Silva Torres, Luciana Cadore Stefani, Felipe Fregni, Wolnei Caumo
BACKGROUND: An imbalance in the excitatory/inhibitory systems in the pain networks may explain the persistent chronic pain after hallux valgus surgery. Thus, to contra-regulate this dysfunction, the use of transcranial direct current stimulation (tDCS) becomes attractive. OBJECTIVE: We tested the hypothesis that two preoperative active(a)-tDCS sessions compared with sham(s)-tDCS could improve the postoperative pain [as indexed by Visual Analogue Scale (VAS) at rest and during walking (primary outcomes)]...
2017: PloS One
Angelo Lavano, Giusy Guzzi, Domenico Chirchiglia
Cortex neuromodulation is promising approach for treatment of some neurological conditions, especially neuropathic pain and Parkinson's disease. Effects of non-invasive cortical stimulation are short lived; transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) may be useful to assess the suitability for invasive cortical stimulation. Direct cortical stimulation (DCS) is the method able to provide long-lasting effects in treatment of neuropathic pain and some symptoms of Parkinson's disease through the use of totally implantable systems that ensure a chronic stimulation...
January 2018: Neurologia i Neurochirurgia Polska
F Fregni, I C Macedo, L N Spezia-Adachi, V L Scarabelot, G Laste, A Souza, Paulo Roberto Stefani Sanches, W Caumo, I L S Torres
BACKGROUND: Chronic stress (CS) is associated with a decrease in pain threshold caused by the changes in neural pain circuits. It can be associated to glucocorticoid imbalance with alterations in neural circuitry. Inhibition of stress-induced pain-related neural changes by using techniques that safely induce neuroplasticity such as transcranial direct current stimulation (tDCS) may prevent hyperalgesia triggered by CS. OBJECTIVE: This study aimed to verify the effect of tDCS performed prior to CS exposure on nociceptive response...
March 2018: Brain Stimulation
Stevan Nikolin, Christina Huggins, Donel Martin, Angelo Alonzo, Colleen K Loo
BACKGROUND: Repeated sessions of transcranial direct current stimulation (tDCS) are increasingly used for therapeutic applications. However, adverse events (AEs) associated with repeated sessions have not been comprehensively evaluated. OBJECTIVE: The aim of this study was therefore to evaluate the safety of repeated sessions of tDCS, examining AE risk relative to tDCS exposure. Further, to identify whether certain participant populations are particularly at risk from tDCS...
March 2018: Brain Stimulation
Aurore Thibaut, Cristina Russo, Aura Maria Hurtado-Puerto, Jorge Leon Morales-Quezada, Alícia Deitos, John Christopher Petrozza, Steven Freedman, Felipe Fregni
Objective: Chronic visceral pain (CVP) syndromes are persistently painful disorders with a remarkable lack of effective treatment options. This study aimed at evaluating the effects of different neuromodulation techniques in patients with CVP on cortical activity, through electreocephalography (EEG) and on pain perception, through clinical tests. Design: A pilot crossover randomized controlled study. Settings: Out-patient. Subjects: Adults with CVP (>3 months)...
2017: Frontiers in Neurology
Giriraj Singh Shekhawat, Sven Vanneste
Tinnitus is the perception of sound in the absence of its external source. Non-invasive neuromodulation techniques have been used in the past decade to investigate the impact of stimulation on tinnitus perception. The objective is to invest the impact of high-definition transcranial direct current stimulation (HD-tDCS) of dorsolateral prefrontal cortex (DLPFC) stimulation on tinnitus loudness and annoyance. Thirteen participants underwent two sessions of HD-tDCS (real and sham) in a double blind, sham controlled, randomized trial...
November 10, 2017: Journal of Neural Transmission
L Angius, A R Mauger, J Hopker, A Pascual-Leone, E Santarnecchi, S M Marcora
BACKGROUND: Transcranial direct current stimulation (tDCS) has been used to enhance endurance performance but its precise mechanisms and effects remain unknown. OBJECTIVE: To investigate the effect of bilateral tDCS on neuromuscular function and performance during a cycling time to task failure (TTF) test. METHODS: Twelve participants in randomized order received a placebo tDCS (SHAM) or real tDCS with two cathodes (CATHODAL) or two anodes (ANODAL) over bilateral motor cortices and the opposite electrode pair over the ipsilateral shoulders...
January 2018: Brain Stimulation
Molly E McLaren, Nicole R Nissim, Adam J Woods
BACKGROUND: There has been increased interest in the potential use of transcranial direct current stimulation (tDCS) as treatment for multiple conditions including depression, pain, and cognitive impairment. However, few studies account for the possible influence of comorbid medications when conducting tDCS research. OBJECTIVE/HYPOTHESIS: This literature review was conducted to examine what is currently known about the impact of medications on tDCS, provide recommendations for future research practices, and highlight areas where more research is needed...
January 2018: Brain Stimulation
Siobhan M Schabrun, Emma Burns, Tribikram Thapa, Paul Hodges
Objective: Neuromodulation is increasingly investigated for the treatment of low back pain (LBP). However, the neurophysiological effects of common neuromodulatory techniques (anodal transcranial direct current stimulation [tDCS] and peripheral electrical stimulation [PES]) have not been investigated in people with chronic LBP. Here we aimed to compare the effect of three neuromodulatory protocols (anodal tDCS, high intensity PES, and a priming protocol of combined tDCS/PES) on primary motor cortex (M1) excitability in people with and without chronic LBP...
July 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
(no author information available yet)
INTRODUCTION: Fibromyalgia is a multisymptomatic diffuse chronic musculoskeletal pain syndrome with evidence of central nervous system dysfunction. Accordingly, non-invasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) may be a complementary therapeutic resource to reduce pain perception. AIMS: To review the potential effectiveness of tDCS to reduce pain in fibromyalgia, to identify the most effective neurostimulation parameters and to delimit its safety...
October 16, 2017: Revista de Neurologia
Rosa Iodice, Fiore Manganelli, Raffaele Dubbioso
BACKGROUND: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system and a leading cause of disability in young adults. Many disabling symptoms in MS, such as spasticity, pain, depression and cognitive deficits are not fully controlled by drug treatment. Non-invasive brain stimulation (NIBS) techniques can be used as tools for modulating altered cortical excitability and plasticity MS patients, providing an improvement in disabling symptoms affecting such patients...
2017: Restorative Neurology and Neuroscience
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