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Osteoarticular infections

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https://www.readbyqxmd.com/read/29113670/primary-arthroplasty-in-healed-osteoarticular-allograft-in-patients-with-history-of-primary-femoral-bone-tumors
#1
Bianca M Verbeek, Courtney L Kaiser, Nuno Rui Paulino Pereira, Francis J Hornicek, Kevin A Raskin, Joseph H Schwab, Santiago A LozanoCalderón
BACKGROUND: Roughly 25-35% of patients who are treated with osteoarticular allograft for primary bone sarcomas or aggressive benign bone tumors require surgery in the long-term due to degenerative changes of the articular surface of the allograft. There are three established methods of reconstruction for this complication; a total hip arthroplasty (THA) or total knee arthroplasty (TKA) in the retained osteoarticular allograft, a proximal or distal endoprosthesis after removal of the allograft, and an allograft-prosthesis composite (APC)...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113159/treatment-of-osteosarcoma-around-the-knee-in-skeletally-immature-patients
#2
Weitao Yao, Qiqing Cai, Jiaqiang Wang, Songtao Gao
Limb sparing surgery in growing young patients with malignant tumors is difficult as invasion of the physis by the tumor or surgical resection through the metaphysis may cause significant limb discrepancy following surgery. At present, hinged tumor prosthesis or biological reconstructions are the main methods following tumor resection in these patients. The aim of the present study was to assess different procedures for the treatment of osteosarcoma around knee joints in immature patients. A retrospective study of 56 patients (<15 years old, open physis) who had been treated for osteosarcoma around the knee joint between January 2007 and December 2015 was performed...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29107417/osteoarticular-and-skin-and-soft-tissue-infections-caused-by-streptococcus-agalactiae-in-elderly-patients-are-frequently-associated-with-bacteremia
#3
Corinne Ruppen, Julia Notter, Carol Strahm, Beat Sonderegger, Parham Sendi
Older persons (≥65 years) are at risk for invasive group B streptococcal (GBS) infections. The most frequent clinical syndromes in 174 infection episodes were osteoarticular (40%) and skin and soft-tissue infections (30%). In 36% of episodes, a companion microorganism was isolated, and in 45%, blood culture results were positive. Antibiotics were streamlined after species identification in 29% of monomicrobial infections. These findings have clinical and therapeutic implications for GBS infections in the elderly...
September 19, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29097247/emerging-group-c-and-g-streptococcal-endocarditis-a-canadian-perspective
#4
Sylvain A Lother, Davinder S Jassal, Philippe Lagacé-Wiens, Yoav Keynan
OBJECTIVES: We sought to determine the incidence of infective endocarditis (IE) from patients with Group C and G streptococci (GCGS) bacteremia, and characterize the burden of disease, clinical characteristics, and outcomes through a case series of patients with GCGS IE. METHODS: Individuals with blood cultures growing GCGS in Manitoba, Canada, between January 2012 and December 2015 were included. Clinical and echocardiographic parameters were collected retrospectively...
October 30, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29081861/role-of-surgery-in-management-of-osteo-articular-tuberculosis-of-the-foot-and-ankle
#5
REVIEW
Mandeep Singh Dhillon, Vikas Agashe, Sampat Dumbre Patil
BACKGROUND: Tuberculosis of the foot and ankle still remains to be a significant problem, especially in the developing countries, and with an increase in incidence in immunosuppressed patients. Treatment is mainly medical using multidrug chemotherapy; surgical interventions range from biopsy, synovectomy and debridement, to joint preserving procedures like distraction in early cases, and arthrodesis of hindfoot joints and the ankle in advanced disease with joint destruction. Surgical Options: All procedures should be done after initiating appropriate medical management...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29034454/successful-treatment-of-sapho-syndrome-with-apremilast
#6
S Adamo, J Nilsson, A Krebs, U Steiner, A Cozzio, L E French, A G A Kolios
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare disease with inflammatory osteoarticular and skin involvement. The pathogenesis of SAPHO syndrome remains unclear, but evidence suggests it may be an autoinflammatory disease triggered upon exposure to infectious agents in genetically predisposed individuals. Induction of the IL-23/Th17 axis as well as neutrophil activation seem to play a key role, and therapies targeting these immunological pathways, including TNF-inhibitors, ustekinumab, secukinumab and the IL-1 inhibitor anakinra are potential treatment options that need further investigation...
October 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29034380/the-immobilization-of-antibiotic-loaded-polymeric-coatings-on-osteoarticular-ti-implants-for-the-prevention-of-bone-infections
#7
Dan Li, Pengfei Lv, Linfeng Fan, Yaoyi Huang, Fei Yang, Xifan Mei, Decheng Wu
Implant-associated infections in orthopaedic surgeries are very critical as they may hinder bone healing, cause implant failure and even progress to osteomyelitis. Drug-eluting implants for local delivery of antibiotics at surgical sites are thought to be promising in preventing infections. Herein, the antibiotic vancomycin was encapsulated in a poly(ethylene glycol) (PEG)-based hydrogel film that was covalently bound to Ti implants and subsequently covered by a PEG-poly(lactic-co-caprolactone) (PEG-PLC) membrane...
October 24, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28991319/-etiology-and-evolution-of-the-osteoarticular-infections-2009-2015-pediatric-hospital-pereira-rossell-uruguay
#8
Carlos Zuníno, Alejandra Vomero, Soledad Pandolfo, Claudia Gutiérrez, Gabriela Algorta, M Catalina Pírez, Gustavo Giachetto
BACKGROUND: The most frequent osteoarticular infections (OAI) etiological agent is Staphylococcus aureus. The prevalence of other microorganisms has changed after the introduction of new vaccines. AIM: To describe the etiology and evolution of the OAIs in children hospitalized in Pediatric Hospital Pereira Rossell between 2009 and 2015. PATIENTS AND METHODS: Joint fluid and bone puncture studies of hospitalized children suspected of OAI. Epidemiological characteristics, isolated microorganisms, complementary tests, initial treatment, complications, and days of hospitalization were analyzed...
June 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28964512/reimplantation-of-an-extruded-osteoarticular-segment-of-the-femur-case-series-and-in-vitro-study-in-a-rat-model
#9
Tao Li, Ze Z Yang, Ming Z Peng, Xiao J Zhou, Zhi Y Liu, Bi Y Rui, Qi Li, Shang C Guo, Ming Xiao, Jin W Wang
BACKGROUND: The treatment of open femur fractures with reimplantation of large extruded segments remains one of the most difficult clinical management scenarios. The situation is even complicated when the extruded segments contains a large osteoarticular segment and no consensus exist about the efficient sterilization. We successfully managed five cases of open femur fracture by reimplantation of a large osteoarticular segment. While the outcomes were favourable, we performed an in vitro investigation in a rat model to determine whether the bone segment preparation strategy was optimal...
September 25, 2017: Injury
https://www.readbyqxmd.com/read/28947652/phasevarion-regulated-virulence-in-the-emerging-paediatric-pathogen-kingella-kingae
#10
Yogitha N Srikhanta, Ka Yee Fung, Georgina L Pollock, Vicki Bennett-Wood, Benjamin P Howden, Elizabeth L Hartland
Kingella kingae is a common etiological agent of paediatric osteoarticular infections. While current research has expanded our understanding of K. kingae pathogenesis, there is a paucity of knowledge about host-pathogen interactions and virulence gene regulation. Many host-adapted bacterial pathogens contain phase variable DNA methyltransferases (mod genes), which can control expression of a regulon of genes (phasevarion), through differential methylation of the genome. Here we identify a phase variable type III mod gene in K...
September 25, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28924723/sixteen-chinese-pediatric-brucellosis-patients-onset-of-fever-in-non-epidemic-areas-and-8-developed-with-osteoarticular-involvement
#11
Xinning Wang, Yuchun Yan, Fengqi Wu, Gaixiu Su, Shengnan Li, Xinyu Yuan, Jianming Lai, Zhixuan Zhou
The purpose of this study is to summarize the manifestations, diagnosis, differential diagnosis, and treatment of childhood brucellosis in non-epidemic areas of China. A retrospective review of 16 admitted children patients with brucella's disease who were diagnosed of brucellosis during the period from 2011 to 2016 was performed. Diagnostic criteria, clinical presentations, and outcomes were recorded. The most common symptom was fever. Osteoarticular involvement was found in 50% of the patients. They were infected by contacting with infected animals or consuming of unpasteurized milk or meat of sheep or goats, also...
September 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28874431/association-between-oropharyngeal-carriage-of-kingella-kingae-and-osteoarticular-infection-in-young-children-a-case-control-study
#12
MULTICENTER STUDY
Jocelyn Gravel, Dimitri Ceroni, Laurence Lacroix, Christian Renaud, Guy Grimard, Eleftheria Samara, Abdessalam Cherkaoui, Gesuele Renzi, Jacques Schrenzel, Sergio Manzano
BACKGROUND: Kingella kingae has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of K. kingae in the oropharynx of preschool children and osteoarticular infections. METHODS: We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and 2016. Potential cases were children aged 6 to 48 months with a presumptive diagnosis of osteoarticular infection according to the treating emergency physician...
September 5, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28835477/is-staphylococcus-lugdunensis-significant-in-clinical-samples
#13
REVIEW
Xavier Argemi, Yves Hansmann, Philippe Riegel, Gilles Prévost
The implication of coagulase-negative staphylococci in human diseases is a major issue, particularly in hospital settings wherein these species often act as opportunistic pathogens. In addition, some coagulase-negative staphylococci such as S. lugdunensis have emerged as pathogenic bacteria, implicated in severe infections, particularly, osteoarticular infections, foreign-body-associated infections, bacteremia, and endocarditis. In vitro studies have shown the presence of several putative virulence factors such as adhesion factors, biofilm production, and proteolytic factors that might explain clinical manifestations...
November 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28802585/genomics-of-the-new-species-kingella-negevensis-diagnostic-issues-and-identification-of-a-locus-encoding-a-rtx-toxin
#14
Onya Opota, Sacha Laurent, Trestan Pillonel, Marie Léger, Sabrina Trachsel, Guy Prod'hom, Katia Jaton, Gilbert Greub
Kingella kingae, producing the cytotoxic RTX protein, is a causative agent of serious infections in humans such as bacteremia, endocarditis and osteoarticular infection, especially in young children. Recently, Kingella negevensis, a related species, has been isolated from the oral cavity of healthy children. In this study, we report the isolation of K. negevensis strain eburonensis, initially misidentified as K. kingae with MALDI-TOF MS, from a vaginal specimen of a patient suffering of vaginosis. The genome sequencing and analysis of this strain together with comparative genomics of the Kingella genus revealed that K...
August 10, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28794176/molecular-tests-that-target-the-rtx-locus-do-not-distinguish-between-kingella-kingae-and-the-recently-described-kingella-negevensis-species
#15
Nawal El Houmami, Janek Bzdrenga, Guillaume André Durand, Philippe Minodier, Hervé Seligmann, Elsa Prudent, Sofiane Bakour, Stéphane Bonacorsi, Didier Raoult, Pablo Yagupsky, Pierre-Edouard Fournier
Kingella kingae is an important invasive pathogen in early childhood. The organism elaborates an RTX toxin presumably restricted to this species. Consequently, real-time quantitative PCR (qPCR) assays targeting the RTX locus have been developed in recent years and are gaining increasing use for the molecular diagnosis of K. kingae infections. However, the present study shows that Kingella negevensis, a Kingella species newly identified in young children, harbors an identical Kingella RTX locus, raising the question of whether K...
October 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28723870/osteoarticular-infections-caused-by-streptococcus-pneumoniae-in-children-in-the-post-pneumococcal-conjugate-vaccine-era
#16
Liset Olarte, Jose Romero, William Barson, John Bradley, Philana Ling Lin, Laurence Givner, Tina Tan, Jill Hoffman, Kristina G Hultén, Edward O Mason, Sheldon L Kaplan
BACKGROUND: Pneumococcal osteoarticular infections (OAIs) are an uncommon manifestation of invasive pneumococcal disease (IPD). We describe the demographic characteristics, hospitalization rate, serotype distribution and antibiotic susceptibility of children with pneumococcal OAI over a 16-year period. METHODS: We identified patients ≤18 years old with pneumococcal OAI at 8 children's hospitals in the United States (2000-2015). Pneumococcal isolates were collected prospectively...
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28696851/us-evaluation-of-juvenile-idiopathic-arthritis-and-osteoarticular-infection
#17
Jie C Nguyen, Kenneth S Lee, Mahesh M Thapa, Humberto G Rosas
Juvenile idiopathic arthritis (JIA) and osteoarticular infection can cause nonspecific articular and periarticular complaints in children. Although contrast material-enhanced magnetic resonance imaging is the reference standard imaging modality, musculoskeletal ultrasonography (US) is emerging as an important adjunct imaging modality that can provide valuable information relatively quickly without use of radiation or the need for sedation. However, diagnostic accuracy requires a systemic approach, familiarity with various US techniques, and an understanding of maturation-related changes...
July 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28683356/scintigraphic-imaging-of-staphylococcus-aureus-infection-using-99m-tc-radiolabeled-aptamers
#18
Sara Roberta Dos Santos, Camila Maria de Sousa Lacerda, Iêda Mendes Ferreira, André Luís Branco de Barros, Simone Odília Fernandes, Valbert Nascimento Cardoso, Antero Silva Ribeiro de Andrade
Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful treatment. Scintigraphy could contribute to this purpose since specific radiotracers were available. Aptamers due to their high specificity have great potential for radiopharmaceuticals development. In the present study scintigraphic images of S...
June 28, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28661965/pyogenic-tenosynovitis-in-infants-a-case-series
#19
Céline Lironi, Christina Steiger, Céline Juchler, Vasiliki Spyropoulou, Eleftheria Samara, Dimitri Ceroni
Pyogenic tenosynovitis is an uncommon condition in children, and there are few published case reports. We present a series of 11 cases who were treated in the Geneva Children Hospital in the last 10 years. Kingella kingae was the main pathogen, and the characteristics of infection (inflammatory indices, clinical findings and severity) are similar to other osteoarticular K. kingae infections in infants.
November 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28648390/clinical-and-microbiological-characteristics-of-unusual-manifestations-of-invasive-pneumococcal-disease
#20
Adrian Sousa, Maria Teresa Pérez-Rodríguez, Andrés Nodar, Lucía Martínez-Lamas, Francisco Jose Vasallo, Maximiliano Álvarez-Fernández, Manuel Crespo
INTRODUCTION: Invasive pneumococcal disease (IPD) typically presents as bacterial pneumonia, meningitis or primary bacteraemia. However, Streptococcus pneumoniae can produce infection at any level of the body (endocarditis, arthritis, spontaneous bacterial peritonitis, etc.), which is also known as unusual IPD (uIPD). There are very limited data available about the clinical and microbiological profile of these uncommon manifestations of pneumococcal disease. Our aim was to analyse clinical forms, microbiological profile, epidemiology and prognosis of a cohort of patients with unusual invasive pneumococcal disease (uIPD)...
June 22, 2017: Enfermedades Infecciosas y Microbiología Clínica
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