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Osteoarticular infections

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https://www.readbyqxmd.com/read/28094193/factors-associated-with-infection-after-reconstructive-shoulder-surgery-for-proximal-humerus-tumors
#1
Sjoerd Th Meijer, Nuno R Paulino Pereira, Sjoerd P F Th Nota, Marco L Ferrone, Joseph H Schwab, Santiago A Lozano Calderón
BACKGROUND: The main reconstruction techniques for proximal humerus tumors include osteoarticular allografts (OAs), endoprostheses (EPs), or allograft prosthetic composites (APCs). A common complication is infection, and constructs involving the use of allografts are believed to be at a higher risk of infection. Literature comparing infection rates between different modalities of reconstruction is scarce and underpowered. The study purposes were (1) to determine and compare the prevalence of infection in patients who underwent reconstruction of the proximal humerus including OAs, EPs, and APCs; (2) to identify preoperative, perioperative, and postoperative predictors of infection that might be modifiable; and (3) to present our protocol of treatment in patients with superficial and deep infections...
January 13, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28053147/bone-and-joint-infections-caused-by-mucormycetes-a-challenging-osteoarticular-mycosis-of-the-twenty-first-century
#2
Saad J Taj-Aldeen, Maria N Gamaletsou, Blandine Rammaert, Nikolaos V Sipsas, Valerie Zeller, Emmanuel Roilides, Dimitrios P Kontoyiannis, Michael Henry, Vidmantas Petraitis, Brad Moriyama, David W Denning, Olivier Lortholary, Thomas J Walsh
Osteomyelitis and arthritis caused by mucormycetes are rare diseases that rank among the most challenging complications in orthopedic and trauma surgery. The aim of this work is to review the epidemiological, clinical, diagnostic, and therapeutic aspects of the osteoarticular mucormycosis with particular emphasis on high-risk patients. A systematic review of osteoarticular mucormycosis was performed using PUBMED and EMBASE databases from 1978 to 2014. Among 34 patients with median age 41 (0.5-73 years), 24 (71%) were males...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28027279/the-influence-of-the-route-of-antibiotic-administration-methicillin-susceptibility-vancomycin-duration-and-serum-trough-concentration-on-outcomes-of-pediatric-staphylococcus-aureus-bacteremic-osteoarticular-infection
#3
J Chase McNeil, Sheldon L Kaplan, Jesus G Vallejo
BACKGROUND: Bacteremia is often one factor used in deciding the need for prolonged intravenous antimicrobial therapy in osteoarticular infections (OAI). We examined treatment practices and outcomes of bacteremic S. aureus osteoarticular infections (BOAI) evaluated at Texas Children's Hospital (TCH). METHODS: Cases of acute hematogenous OAI in children with positive blood cultures for S. aureus at TCH from 2011-2014 were reviewed. Orthopedic complications included chronic osteomyelitis, growth arrest, pathologic fracture, avascular necrosis and chronic dislocation...
December 23, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28002357/pediatric-sacroiliitis-clinical-and-microbiologic-differences-between-infants-and-children-adolescents
#4
Ambra Donzelli, Eleftheria Samara, Vassiliki Spyropoulou, Céline Juchler, Dimitri Ceroni
BACKGROUND: The aim of this study was to improve knowledge of pediatric pyogenic sacroiliitis (PSI) in the pediatric population based on a consecutive case series. METHOD: We conducted a single-center cross-sectional study on 16 patients admitted to the emergency department of our Hospital between January 1990 and December 2015 with a confirmed diagnosis of PSI. The patients were divided into 2 groups by age: infants (6 months - 4 years) and children-adolescents (4-16 years)...
December 19, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27956728/kingella-kingae-chest-mass-mimicking-a-tumor-in-an-11-month-old-baby
#5
Halima Dabaja-Younis, Imad Kassis, Anat Ilivitzki, Ran Steinberg, Yael Shachor-Meyouhas
Kingella kingae has been recognized as a common etiology of pediatric osteoarticular infections, especially among children younger than 5 years of age. In recent years, there have been reported cases of unusual manifestations. We report a rare case of a chest mass mimicking a tumor in an 11-month-old baby.
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27869401/yersiniosis-in-poland-in-2014
#6
Sylwia Kamińska, Małgorzata Sadkowska-Todys
OBJECTIVE: The aim of the study is to present the epidemiological situation of yersiniosis in Poland in 2014 and compare it with the situation in the previous years. MATERIAL AND METHODS: The evaluation was based on analysis of data from the annual bulletins “Infectious diseases and poisoning in Poland” for the period 2009-2014 (MP Czarkowski et al., National Institute of Hygiene and GIS – Chief Sanitary Inspectorate), interviews of individual yersiniosis cases, sent by the sanitary-epidemiological stations from the whole country and the data on deaths from the Department of Demographic Studies of the Central Statistical Office...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27855056/-mixed-knee-arthrodesis-a-rescue-alternative-in-knee-periprosthetic-joint-infection
#7
Roberto Enrique López-Cervantes, Adrián Huematzin Rivera-Villa, Adrián Miguel-Pérez, René Morales-de Los Santos, Rubén Torres-González, José Manuel Pérez-Atanasio
BACKGROUND: Knee arthrodesis is a rescue procedure for patients with knee periprosthetic joint infection who are not candidates for a revision surgery. The actual methods present a high complication rate with only moderate efectivity. METHODS: We retrospectively analyzed 17 cases, of patients with knee periprosthetic joint infection and bone loss treated by intramedular expandable nail and monoplanar external fixator with a mínimum evolution of 1 year, evaluating the medical records and digitalized X-rays by 2 sub specialized doctors in osteoarticular rescue surgery...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27844159/clinical-and-epidemiological-differences-between-implant-associated-and-implant-free-orthopaedic-infections
#8
Céline Cuérel, Sophie Abrassart, Julien Billières, Diego Andrey, Domizio Suva, Victor Dubois-Ferrière, Ilker Uçkay
PURPOSE: Although there have been many publications regarding the risk factors for implant-associated orthopaedic infections, none have investigated how clinical presentations and epidemiology may differ between infections with and without osteosynthetic material. METHODS: We pooled clinical data from several databases of adult patients with orthopaedic infections hospitalized at Geneva University Hospitals from January 2004 to December 2014. RESULTS: Among 2740 episodes of orthopaedic infections, 76% were implant-free osteoarticular or soft tissue infections...
February 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27813241/population-pharmacokinetics-of-rifampicin-in-adult-patients-with-osteoarticular-infections-interaction-with-fusidic-acid
#9
A Marsot, A Ménard, J Dupouey, C Muziotti, R Guilhaumou, O Blin
AIMS: Rifampicin represents the key antibiotic for management of osteoarticular infections. An important pharmacokinetic variability has already been described, incriminating notably absorption and metabolism. All previous pharmacokinetic studies were only focused on patient treated for tuberculosis. The objective of this study was to describe a population pharmacokinetic model of rifampicin in patients with staphylococcal osteoarticular infections, data which have not been investigated to date...
November 4, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27761291/langerhans-cell-histiocytosis-with-atypical-intervertebral-disc-and-sacroiliac-joint-involvement-mimicking-osteoarticular-tuberculosis-in-an-adult
#10
Zeynep Maraş Özdemir, Ayşegül Sağır Kahraman, Cemile Ayşe Görmeli, Reşit Sevimli, Nusret Akpolat
BACKGROUND: Langerhans cell histiocytosis (LCH), typically found in children, is a rare single or multisystem disorder with a wide range of clinical and radiological manifestations. Unusual presentations of LCH are occasionally encountered and it may be difficult to distinguish LCH from an infection or a benign or malignant tumor. RESULTS: A 35-year-old female presented with pain in her back and left buttock, malaise, and weight loss, with a duration of several months...
September 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27760194/kingella-kingae-expresses-four-structurally-distinct-polysaccharide-capsules-that-differ-in-their-correlation-with-invasive-disease
#11
Kimberly F Starr, Eric A Porsch, Patrick C Seed, Christian Heiss, Radnaa Naran, L Scott Forsberg, Uri Amit, Pablo Yagupsky, Parastoo Azadi, Joseph W St Geme
Kingella kingae is an encapsulated gram-negative organism that is a common cause of osteoarticular infections in young children. In earlier work, we identified a glycosyltransferase gene called csaA that is necessary for synthesis of the [3)-β-GalpNAc-(1→5)-β-Kdop-(2→] polysaccharide capsule (type a) in K. kingae strain 269-492. In the current study, we analyzed a large collection of invasive and carrier isolates from Israel and found that csaA was present in only 47% of the isolates. Further examination of this collection using primers based on the sequence that flanks csaA revealed three additional gene clusters (designated the csb, csc, and csd loci), all encoding predicted glycosyltransferases...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27745829/-treatment-and-progression-of-acute-communautary-osteoarticular-infections-in-healthy-children-a-retrospective-monocentric-study-of-64%C3%A2-patients
#12
A Lemoine, F Baudin, R Vialle, E Grimprel
INTRODUCTION: The prognosis of osteoarticular infections has improved over the past 20 years but it still remains potentially severe. The treatment of these infections has been simplified and shortened. In 2008, the Pediatric Infectious Disease Group (GPIP) established new therapeutic guidelines in order to standardize treatment in France. The aim of this study is to analyze practices in a Parisian hospital and assess the efficacy of this treatment in short and medium terms. MATERIALS AND METHODS: This retrospective study focused on patients older than 3 months, without comorbidities, who were hospitalized for an acute osteoarticular infection in 2012 at Trousseau Hospital (Paris), with a follow-up of at least 4 weeks...
November 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27716100/temporal-trends-of-%C3%AE-haemolytic-streptococcal-osteoarticular-infections-in-western-norway
#13
Oddvar Oppegaard, Steinar Skrede, Haima Mylvaganam, Bård Reiakvam Kittang
BACKGROUND: Beta-haemolytic streptococci are important contributors to the global burden of osteoarticular infections (OAI). Knowledge on the disease traits specific for streptococcal OAI, however, remains scarce. We wished to explore temporal trends of OAI caused by Group A Streptococci (GAS), Group B Streptococci (GBS) and Group C and G Streptococci (GCGS), and furthermore, to describe the associated host and pathogen characteristics. METHODS: All cases of microbiologically verified β-haemolytic streptococcal OAI in Health Region Bergen, Norway, in the period 1999-2013 were retrospectively identified...
October 4, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27714987/in-vitro-characterization-of-biofilms-formed-by-kingella-kingae
#14
J B Kaplan, V Sampathkumar, M Bendaoud, A K Giannakakis, E T Lally, N V Balashova
The Gram-negative bacterium Kingella kingae is part of the normal oropharyngeal mucosal flora of children <4 years old. K. kingae can enter the submucosa and cause infections of the skeletal system in children, including septic arthritis and osteomyelitis. The organism is also associated with infective endocarditis in children and adults. Although biofilm formation has been coupled with pharyngeal colonization, osteoarticular infections, and infective endocarditis, no studies have investigated biofilm formation in K...
October 7, 2016: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/27680581/the-effect-of-cement-augmentation-and-anteromedial-plating-on-proximal-humerus-allograft-reconstruction
#15
Khodamorad Jamshidi, Farid Najd-Mazhar, Farshad Abolghasemzadeh Ahangar, Alireza Mirzaei
BACKGROUND: Limb salvage following the resection of tumor from the proximal part of the humerus, poses many challenges, and there is no consensus regarding the best reconstructive technique after proximal humerus resection. The aim of this study was to evaluate the effect of anteromedial placing of the plate in the absence of deltoid muscle and cement augmentation on the functional outcome, complication rate and survival of proximal humerus allograft reconstruction. PATIENTS AND METHODS: A number of 36 osteoarticular allograft reconstructions of proximal humerus were included in final study...
September 25, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27680031/management-of-infections-in-rheumatic-patients-receiving-biological-therapies-the-portuguese-society-of-rheumatology-recommendations
#16
Lídia Teixeira, Ana Rita Fonseca, Gisela Eugénio, Marília Rodrigues, Nikita Khmelinskii, Sílvia Fernandes, Sofia Serra, Tiago Costa, Maria José Santos
INTRODUCTION: Infections are a major cause of morbidity and mortality in systemic inflammatory rheumatic diseases and the management of infectious complications in patients under biological therapies deserves particular attention. OBJECTIVE: Develop evidence-based recommendations for the management of infections in rheumatic patients receiving biological therapies. METHODS: A search in PubMed (until 10 November 2014) and EMBASE (until 20 December 2014) databases was performed...
August 6, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27677682/use-of-maldi-tof-mass-spectrometry-after-liquid-enrichment-bd%C3%A2-bactec%C3%A2-for-rapid-diagnosis-of-bone-and-joint-infections
#17
Elise Lallemand, Cédric Arvieux, Guillaume Coiffier, Jean-Louis Polard, Jean-David Albert, Pascal Guggenbuhl, Anne Jolivet-Gougeon
Advantages of MALDI-TOF MS (MS) were evaluated for diagnosis of bone and joint infections after enrichment of synovial fluid (SF) or crushed osteoarticular samples (CSs). MS was performed after enrichment of SF or crushed osteoarticular samples CS (n = 108) in both aerobic and anaerobic vials. Extraction was performed on 113 vials (SF: n = 47; CS: n = 66), using the Sepsityper(®) kit prior identification by MS. The performances of MS, score and reproducibility results on bacterial colonies from blood agar and on pellets after enrichment in vials, were compared...
September 24, 2016: Research in Microbiology
https://www.readbyqxmd.com/read/27676732/total-hip-arthroplasty-infection-due-to-mycobacterium-bovis-after-bcg-therapy
#18
Alban Fouasson-Chailloux, Benoit Metayer, Pierre Menu, Lydie Khatchatourian, Joelle Glemarec, Marc Dauty
OBJECTIVE: The loosening of total joint replacement is a frequent complication after total hip arthroplasty (THA). Septic osteolysis should always be feared. We report here a rare case of hip arthroplasty infection due to Mycobacterium bovis after Bacillus Calmette-Guerin (BCG) therapy in a context of bladder cancer. OBSERVATIONS: A 70-year-old man was referred to the department of rheumatology in September 2015, because of a total functional disability of the left lower limb...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27669685/low-prevalence-of-kingella-kingae-carriage-in-children-aged-6-48-months-in-sydney-australia
#19
Ameneh Khatami, Braden Rl Rivers, Alexander C Outhred, Alison M Kesson
AIM: A prospective observational study was conducted to estimate the prevalence of oropharyngeal carriage of Kingella kingae in healthy Australian pre-school children. METHODS: Screening for carriage of K. kingae as well as Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Haemophilus influenzae, and K. kingae was undertaken using a single bacterial throat swab taken from well children aged 6 months to 4 years. Standard laboratory procedures were used for culture and identification of organisms...
September 27, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27639784/unusual-case-of-paediatric-septic-arthritis-of-the-lumbar-facet-joints-due-to-kingella-kingae
#20
M Le Hanneur, C Vidal, C Mallet, K Mazda, B Ilharreborde
A 32-month-old boy presented with febrile limping that had developed over 6days, associated with right lumbosacral inflammatory swelling. Magnetic resonance imaging (MRI) showed joint effusion of the right L5-S1 zygapophyseal joint, complicated by destructive osteomyelitis of the L5 articular process and paraspinal abscess. Surgery was decided to evacuate the fluid accumulation and rule out differential diagnoses. The diagnosis of septic arthritis of the facet joint was confirmed intraoperatively; real-time quantitative PCR analysis identified Kingella kingae...
September 14, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
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