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https://www.readbyqxmd.com/read/27911008/comparison-of-neuropathology-in-parkinson-s-disease-subjects-with-and-without-deep-brain-stimulation
#1
Gian D Pal, Bichun Ouyang, Geidy Serrano, Holly A Shill, Christopher Goetz, Glenn Stebbins, Leo Verhagen Metman, Erika Driver-Dunckley, Shyamal H Mehta, John N Caviness, Marwan N Sabbagh, Charles H Adler, Thomas G Beach
BACKGROUND: The aim of this postmortem study was to compare, in Parkinson's disease subjects with and without bilateral subthalamic nucleus deep brain stimulation (STN-DBS), the loss of pigmented neurons within the substantia nigra and pathological alpha-synuclein density within the SN and other brain regions. METHODS: PD subjects were identified from the Arizona Study of Aging and Neurodegenerative Disorders database (STN-DBS = 11, non-DBS = 156). Pigmented neuron loss scores within the substantia nigra as well as alpha-synuclein density scores within the substantia nigra and 9 other brain regions were compared, the latter individually and in summary as the Lewy body brain load score...
December 2, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27908501/prospective-evaluation-of-surgical-palliative-care-immersion-training-for-general-surgery-residents
#2
Mustafa Raoof, Lisa O'Neill, Leigh Neumayer, Mindy Fain, Robert Krouse
BACKGROUND: Palliative care competencies in surgical training are recognized to improve the care of surgical patients with advanced or life-threatening illnesses. Formal programs to teach these competencies are lacking. The study aims to assess the feasibility and utility of a unique surgical palliative care immersion training program. STUDY DESIGN: A half-day Surgical Palliative Care Immersion Training (SPCIT) was developed using the American College of Surgeon's manual titled "Surgical Palliative Care: A Resident's Guide" as a framework...
November 27, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27903576/first-reported-case-of-peroneal-tenosynovitis-caused-by-coccidioides-immitis-successfully-treated-with-fluconazole
#3
Aneela Majeed, Waqas Ullah, Auon Abbas Hamadani, Anca Georgescu
Coccidioidomycosis is an insidious infection caused by Coccidioides spp (C. immitis and C. posadasii). Disseminated disease occasionally involves tendon sheaths and synovium of the joints leading to tenosynovitis. Here, we describe the case of a 72-year-old woman from southern Arizona, who presented with right ankle pain, redness and swelling for 2 months. Her serum IgG was positive for C. immitis on complement fixation, and her MRI of the right ankle joint showed extensive tenosynovitis of the right peroneal tendons, and subtalar joint effusions with associated synovitis...
November 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27903084/assessment-of-corticosteroid-related-quality-of-care-measures-for-uc-and-cd-in-the-united-states-a-claims-data-analysis
#4
David T Rubin, Haridarshan Patel, Sherry Shi, Reema Mody
OBJECTIVE: To evaluate corticosteroid (CS)-related quality of care indicators in patients with ulcerative colitis (UC) and Crohn's disease (CD) in the US. METHODS: Adults diagnosed with UC or CD and prescription fills for an oral CS were identified from a large commercial US claims database (2005- 2013). Quality indicators included prolonged CS use (≥60 days), use of CS-sparing therapy, and bone loss assessment. State-level variations in quality of care indicators were estimated using logistic regression models adjusting for age, gender, insurance plan type, and CD severity...
December 1, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27896662/investigating-the-additive-interaction-of-qt-prolonging-drugs-in-older-people-using-claims-data
#5
Andreas D Meid, Anna von Medem, Dirk Heider, Jürgen-Bernhard Adler, Christian Günster, Hanna M Seidling, Renate Quinzler, Hans-Helmut König, Walter E Haefeli
INTRODUCTION: Drugs that potentially prolong the QT interval carry the risk of life-threatening Torsades de pointes (TdP) ventricular arrhythmia. OBJECTIVE: The objective of this study was to investigate the potential additive risk for ventricular arrhythmia with concomitant prescriptions of QT-prolonging drugs. METHODS: Claims data for persons aged ≥65 years between 2010 and 2012 in Germany were analyzed and all cases hospitalized for ventricular arrhythmia were selected...
November 29, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27894018/managing-mosquito-spaces-citizen-self-governance-of-disease-vectors-in-a-desert-landscape
#6
Nicolena vonHedemann, Paul Robbins, Melinda K Butterworth, Katheryn Landau, Cory W Morin
Public health agencies' strategies to control disease vectors have increasingly included "soft" mosquito management programs that depend on citizen education and changing homeowner behaviors. In an effort to understand public responses to such campaigns, this research assesses the case of Tucson, Arizona, where West Nile virus presents a serious health risk and where management efforts have focused on public responsibility for mosquito control. Using surveys, interviews, and focus groups, we conclude that citizens have internalized responsibilities for mosquito management but also expect public management of parks and waterways while tending to reject the state's interference with privately owned parcels...
November 25, 2016: Health & Place
https://www.readbyqxmd.com/read/27888746/maternal-exposure-to-ozone-and-pm2-5-and-the-prevalence-of-orofacial-clefts-in-four-u-s-states
#7
Ying Zhou, Suzanne M Gilboa, Michele L Herdt, Philip J Lupo, W Dana Flanders, Yang Liu, Mikyong Shin, Mark A Canfield, Russell S Kirby
BACKGROUND: While there is some evidence that maternal exposure to ambient air pollution is associated with orofacial clefts in offspring, the epidemiologic studies have been largely equivocal. We evaluated whether maternal exposure to elevated county-level ambient fine particulate matter with aerodynamic diameter ≤2.5µm (PM2.5) and ozone during early gestation was associated with a higher prevalence of orofacial clefts. METHODS: Birth data consisting of 4.7 million births from 2001 to 2007 were obtained from National Birth Defects Prevention Network for four states - Arizona, Florida, New York (excluding New York City), and Texas...
November 23, 2016: Environmental Research
https://www.readbyqxmd.com/read/27880753/notes-from-the-field-community-based-prevention-of-rocky-mountain-spotted-fever-sonora-mexico-2016
#8
Anne Straily, Naomi Drexler, Denica Cruz-Loustaunau, Christopher D Paddock, Gerardo Alvarez-Hernandez
Rocky Mountain spotted fever (RMSF), a life-threatening tickborne zoonosis caused by Rickettsia rickettsii, is a reemerging disease in Mexico (1,2). R. rickettsii is an intracellular bacterium that infects vascular endothelium and can cause multisystem organ failure and death in the absence of timely administration of a tetracycline-class antibiotic, typically doxycycline. Epidemic RMSF, as described in parts of Arizona and Mexico, is associated with massive local infestations of the brown dog tick (Rhiphicephalus sanguineus sensu lato) on domestic dogs and in peridomestic settings that result in high rates of human exposure; for example, during 2003-2012, in Arizona the incidence of RMSF in the three most highly affected communities was 150 times the U...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27878677/rating-the-digital-help-electronic-medical-records-software-providers-and-physicians
#9
Richard J Butler, William G Johnson
To separate the effects of physicians' characteristics on the perceived productivity of EMRs from the effects of limitations on usability inherent in EMR design, a multivariate regression model is used to estimate the factors influencing physicians' rankings of five attributes of their EMRs, namely; ease of use and reliability; the EMRs effect on physician and staff productivity and the EMRs performance vs. vendor's promises. We divide the factors influencing the rankings into three groups: physician characteristics, EMR characteristics and practice characteristics (type of practice, size, and location)...
September 2016: Int J Health Econ Manag
https://www.readbyqxmd.com/read/27875641/saving-science-by-doing-less-of-it
#10
Gregory E Kaebnick
In the current issue of The New Atlantis, Daniel Sarewitz, professor of science and society at Arizona State University, argues that science is broken because it is managed and judged by scientists themselves, operating under Vannevar Bush's famous 1945 declaration that scientific progress depends on the "free play of free intellects … dictated by their curiosity." With that scientific agenda, society ends up with a lot of unnecessary, uncoordinated, and unproductive research. To save science, holds Sarewitz, we need to put it in the hands of people who are looking for practical solutions to specific problems...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27872037/internet-based-delivery-of-evidence-based-health-promotion-programs-among-american-indian-and-alaska-native-youth-a-case-study
#11
Christine M Markham, Stephanie Craig Rushing, Cornelia Jessen, Gwenda Gorman, Jennifer Torres, William E Lambert, Alexander V Prokhorov, Leslie Miller, Kelly Allums-Featherston, Robert C Addy, Melissa F Peskin, Ross Shegog
BACKGROUND: American Indian and Alaska Native (AI/AN) youth face multiple health challenges compared to other racial/ethnic groups, which could potentially be ameliorated by the dissemination of evidence-based adolescent health promotion programs. Previous studies have indicated that limited trained personnel, cultural barriers, and geographic isolation may hinder the reach and implementation of evidence-based health promotion programs among AI/AN youth. Although Internet access is variable in AI/AN communities across the United States, it is swiftly and steadily improving, and it may provide a viable strategy to disseminate evidence-based health promotion programs to this underserved population...
November 21, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27869600/reemergence-of-st-louis-encephalitis-virus-california-2015
#12
Gregory S White, Kelly Symmes, Pu Sun, Ying Fang, Sandra Garcia, Cody Steiner, Kirk Smith, William K Reisen, Lark L Coffey
St. Louis encephalitis virus infection was detected in summer 2015 in southern California after an 11-year absence, concomitant with an Arizona outbreak. Sequence comparisons showed close identity of California and Arizona isolates with 2005 Argentine isolates, suggesting introduction from South America and underscoring the value of continued arbovirus surveillance.
December 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27865047/carbon-lost-and-carbon-gained-a-study-of-vegetation-and-carbon-tradeoffs-among-diverse-land-uses-in-the-phoenix-az
#13
Melissa R McHale, Sharon Hall, Anandamayee Majumdar, Nancy B Grimm
Human modification and management of urban landscapes drastically alters vegetation and soils, thereby altering carbon (C) storage and rates of net primary productivity (NPP). Complex social and ecological processes drive vegetation cover in cities, leading to heterogeneity in C dynamics depending on regional climate, land use, and land cover. Recent work has demonstrated homogenization in ecological processes within human-dominated landscapes (the urban convergence hypothesis) in soils and biotic communities...
November 19, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27864102/a-health-sciences-student-run-smoking-cessation-clinic-experience-within-a-homeless-population
#14
Kelsey Buckley, Laura Tsu, Sabrina Hormann, Kevin Giang, April Bills, Nicole Early, Rebekah Jackowski
OBJECTIVE: The primary objective is to describe a professional and graduate student-run approach to smoking cessation education combined with motivational interviewing and pharmacotherapy in regard to the frequency of follow-up with a smoking cessation quitline program in the homeless population. The secondary objective is to assess participants' self-reported level of confidence, knowledge, and willingness to quit before and after participation in the student-run smoking cessation clinic...
November 15, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27862891/effects-of-foliar-and-systemic-insecticides-on-whitefly-transmission-and-incidence-of-cucurbit-yellow-stunting-disorder-virus
#15
S J Castle, John Palumbo, Paul Merten, Charles Cowden, Nilima Prabhaker
BACKGROUND: Cucurbit yellow stunting disorder virus (CYSDV) is a cosmopolitan viral disease transmitted by Bemisia tabaci that infects cucurbit crops. Cantaloupe production in the southwestern U.S. has been confronted by epidemics of CYSDV since 2006 when it was first identified in Arizona and California. As a phloem-limited virus that is vectored in a semi-persistent manner by B. tabaci, CYSDV has transmission characteristics that may be suppressed by select insecticide applications...
November 11, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27859967/slow-carbon-and-nutrient-accumulation-in-trees-established-following-fire-exclusion-in-the-southwestern-united-states
#16
Jason P Kaye, Margot W Kaye, Stephen C Hart, W Wallace Covington, Peter Z Fulé
Increasing tree density that followed fire exclusion after the 1880s in the southwestern United States may have also altered nutrient cycles and led to a carbon (C) sink that constitutes a significant component of the U.S. C budget. Yet, empirical data quantifying century-scale changes in C or nutrients due to fire exclusion are rare. We used tree-ring reconstructions of stand structure from five ponderosa pine-dominated sites from across northern Arizona to compare live tree C, nitrogen (N), and phosphorus (P) storage between the 1880s and 1990s...
December 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27859923/patient-compliance-in-the-setting-of-bi-rads-category-3-what-factors-impact-compliance-with-short-term-follow-up-recommendations
#17
Marisa H Borders, Lucy Cheng, Kimberly A Fitzpatrick, Elizabeth A Krupinski
The study aims to define how imaging findings, patient demographics, patient-provider interactions, and health care practices may affect a woman's decision to follow-up in the setting of a BI-RADS Category 3. A total of 398 women from the University of Arizona Breast Imaging Center with a BI-RADS Category 3 assessment for mammography and/or ultrasound findings were evaluated between February 2012 and June 2014. Demographic information was analyzed for all patients, regardless of follow-up. Women who returned for follow-up within the recommended time period were given one survey at the time of their follow-up appointment, and women who returned for follow-up, but later than recommended, were given a separate survey to complete...
November 17, 2016: Breast Journal
https://www.readbyqxmd.com/read/27856341/routine-pelvic-examinations-a-descriptive-cross-sectional-survey-of-women-s-attitudes-and-beliefs-after-new-guidelines
#18
Juliana M Kling, Suneela Vegunta, Mina Al-Badri, Stephanie S Faubion, Heather E Fields, Amit A Shah, Mark R Wallace, Barbara E Ruddy, Michael J Bryan, M'hamed Temkit, Kathy L MacLaughlin
Routine pelvic examinations have been a fundamental part of the annual female examination. The 2014 American College of Physicians (ACP) guideline recommends against routine pelvic examinations in asymptomatic, nonpregnant, average-risk women. Our aim was to evaluate women's attitudes and beliefs about pelvic examinations and how knowledge of the new guidelines contributes to attitudes and beliefs. A descriptive cross-sectional study was performed using a self-administered written survey developed through literature review and pretested and revised on the basis of staff suggestions...
November 14, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27849147/teen-birth-rates-for-urban-and-rural-areas-in-the-united-states-2007-2015
#19
Brady E Hamilton, Lauren M Rossen, Amy M Branum
Data from the National Vital Statistics System •Birth rates for teenagers aged 15-19 declined in urban and rural counties from 2007 through 2015, with the largest declines in large urban counties and the smallest declines in rural counties. •From 2007 through 2015, the teen birth rate was lowest in large urban counties and highest in rural counties. •Declines in teen birth rates in all urban counties between 2007 and 2015 were largest in Arizona, Massachusetts, Connecticut, Minnesota, and Colorado, with 17 states experiencing a decline of 50% or more...
November 2016: NCHS Data Brief
https://www.readbyqxmd.com/read/27829963/are-there-disparities-in-thrombolytic-treatment-and-mortality-in-acute-ischemic-stroke-in-the-hispanic-population-living-in-border-states-versus-nonborder-states
#20
Ameer E Hassan, David H Kassel, Malik M Adil, Wondwossen G Tekle, Adnan I Qureshi
BACKGROUND: Recent studies have found an underutilization of hospital in-patient care for coronary artery disease in Hispanics living in border states. OBJECTIVE: To identify acute treatment disparities in acute ischemic stroke Hispanic patients and determine the effect of such disparity on patient outcomes. METHODS: We identified Hispanic and non-Hispanic acute ischemic stroke patients from the Nationwide Inpatient Sample-2011 data files...
October 2016: Journal of Vascular and Interventional Neurology
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