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https://www.readbyqxmd.com/read/29457563/novel-use-of-the-cochlear-%C3%A2-hybrid-ci24reh-cochlear-implant
#1
Yahya Atiya, Mohamed Razwi Ahmed, Dani Schlesinger-Michelow
Cochlear implantation is becoming more widespread. From its early days to date, huge strides have been made in the technology and surgical technique. However, one challenge remains: implanting malformed or abnormal cochleae. Even more challenging is a cochlea that appears normal at first glance, but is not. We present a case of a child with chondrodysplasia punctata, who had apparently morphologically normal inner ears, but with one major obstacle: the cochlea was smaller than normal in all dimensions. To the best of our knowledge, this is the first case described, and the solution is a novel one as well...
May 2018: Cochlear Implants International
https://www.readbyqxmd.com/read/29453947/evaluation-of-the-effects-of-rp5063-a-novel-multimodal-serotonin-receptor-modulator-as-single-agent-therapy-and-co-administrated-with-sildenafil-bosentan-and-treprostinil-in-a-monocrotaline-induced-pulmonary-arterial-hypertension-rat-model
#2
Laxminarayan Bhat, Jon Hawkinson, Marc Cantillon, Dasharatha G Reddy, Seema R Bhat, Charles-E Laurent, Annie Bouchard, Marzena Biernat, Dany Salvail
Pulmonary arterial hypertension (PAH), a condition that is defined by pulmonary vasculature constriction and remodeling, involves dysfunctional signaling of the serotonin (5-HT) receptors, 5-HT 2/2B/7 . In a rat model of monocrotaline (MCT)-induced PAH, the effectiveness of RP5063 (RP), a dopamine and 5-HT receptor modulator, was evaluated as monotherapy and as an adjunct to standard PAH treatments. After a single 60mg/kg dose of MCT, rats received vehicle (MCT+Veh; gavage twice-daily [b.i.d.]), RP (10mg/kg; gavage b...
February 14, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29451664/update-on-antiphospholipid-antibody-syndrome
#3
Michelle Remião Ugolini Lopes, Adriana Danowski, Andreas Funke, Jozelia Rêgo, Roger Levy, Danieli Castro Oliveira de Andrade
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. Most APS events are directly related to thrombotic events, which may affect small, medium or large vessels. Other clinical features like thrombocytopenia, nephropathy, cardiac valve disease, cognitive dysfunction and skin ulcers (called non-criteria manifestations) add significant morbidity to this syndrome and represent clinical situations that are challenging...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29449646/assessing-cetacean-surveys-throughout-the-mediterranean-sea-a-gap-analysis-in-environmental-space
#4
Laura Mannocci, Jason J Roberts, Patrick N Halpin, Matthieu Authier, Oliver Boisseau, Mohamed Nejmeddine Bradai, Ana Cañadas, Carla Chicote, Léa David, Nathalie Di-Méglio, Caterina M Fortuna, Alexandros Frantzis, Manel Gazo, Tilen Genov, Philip S Hammond, Draško Holcer, Kristin Kaschner, Dani Kerem, Giancarlo Lauriano, Tim Lewis, Giuseppe Notarbartolo di Sciara, Simone Panigada, Juan Antonio Raga, Aviad Scheinin, Vincent Ridoux, Adriana Vella, Joseph Vella
Heterogeneous data collection in the marine environment has led to large gaps in our knowledge of marine species distributions. To fill these gaps, models calibrated on existing data may be used to predict species distributions in unsampled areas, given that available data are sufficiently representative. Our objective was to evaluate the feasibility of mapping cetacean densities across the entire Mediterranean Sea using models calibrated on available survey data and various environmental covariates. We aggregated 302,481 km of line transect survey effort conducted in the Mediterranean Sea within the past 20 years by many organisations...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448220/trunk-postural-balance-and-low-back-pain-reliability-and-relationship-with-clinical-changes-following-a-lumbar-stabilization-exercise-program
#5
Ali Shahvarpour, Dany Gagnon, Richard Preuss, Sharon M Henry, Christian Larivière
Lumbar stabilization programs reduce pain and disability, but the mechanisms of action underlying this treatment are unknown. Trunk postural control during unstable sitting represents a surrogate measure of motor control mechanisms involved to maintain the dynamic stability of the spine. This exploratory study aimed to determine the reliability of trunk postural control measures over an 8-week interval, their sensitivity to low back pain status and treatment and their relationship with clinical outcomes. Trunk postural control measures were determined in patients with low back pain before and after an 8-week lumbar stabilization exercise program...
February 9, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29447366/parent-of-origin-dependent-gene-expression-in-male-and-female-schistosome-parasites
#6
Julien Kincaid-Smith, Marion A L Picard, Céline Cosseau, Jérôme Boissier, Dany Severac, Christoph Grunau, Eve Toulza
Schistosomes are the causative agents of schistosomiasis, a Neglected Tropical Disease affecting over 230 million people worldwide. Additionally to their major impact on human health, they are also models of choice in evolutionary biology. These parasitic flatworms are unique among the common hermaphroditic trematodes as they have separate sexes. This so-called « evolutionary scandal » displays a female heterogametic genetic sex-determination system (ZZ males and ZW females), as well as a pronounced adult sexual dimorphism...
February 12, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29441045/network-analyses-in-plant-pathogens
#7
REVIEW
David Botero, Camilo Alvarado, Adriana Bernal, Giovanna Danies, Silvia Restrepo
Even in the age of big data in Biology, studying the connections between the biological processes and the molecular mechanisms behind them is a challenging task. Systems biology arose as a transversal discipline between biology, chemistry, computer science, mathematics, and physics to facilitate the elucidation of such connections. A scenario, where the application of systems biology constitutes a very powerful tool, is the study of interactions between hosts and pathogens using network approaches. Interactions between pathogenic bacteria and their hosts, both in agricultural and human health contexts are of great interest to researchers worldwide...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29440804/prevalence-and-severity-of-sleep-disturbances-among-patients-with-early-breast-cancer
#8
Rami Fakih, Mahmoud Rahal, Lara Hilal, Lana Hamieh, Mohammed Dany, Simone Karam, Latifa Shehab, Nagi S El Saghir, Arafat Tfayli, Ziad Salem, Hazem Assi, Sally Temraz, Ali Shamseddine, Deborah Mukherji
Context: Data regarding health-related quality of life in breast cancer patients in the Middle East are limited with fatigue and sleep disturbance being the most distressing symptoms reported by patients treated for early breast cancer. Aims: The aim of this study was to examine the prevalence and incidence of insomnia among patients with early-stage breast cancer patients treated with chemotherapy. Subjects and Methods: This was a prospective cohort study...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29435590/association-of-retinal-vascular-caliber-and-age-related-macular-degeneration-in-patients-with-the-acquired-immunodeficiency-syndrome
#9
Douglas A Jabs, Mark L Van Natta, Jeong Won Pak, Ronald P Danis, Peter W Hunt
Purpose: To evaluate the relationship between retinal vascular caliber and AMD in patients with AIDS. Methods: Participants enrolled in the Longitudinal Study of the Ocular Complications of AIDS had retinal photographs taken at enrollment. Retinal vascular caliber (central retinal artery equivalent [CRAE] and central retinal vein equivalent [CRVE]) and intermediate-stage AMD were determined from these retinal photographs. Photographs were evaluated by graders at a centralized reading center, using the Age-Related Eye Disease Study grading system for AMD and semiautomated techniques for evaluating retinal vascular caliber...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29427836/dnm1-encephalopathy-atypical-phenotype-with-hypomyelination-due-to-a-novel-de-novo-variant-in-the-dnm1-gene
#10
Miriam Kolnikova, Martina Skopkova, Denisa Ilencikova, Tomas Foltan, Jaroslava Payerova, Daniel Danis, Iwar Klimes, Juraj Stanik, Daniela Gasperikova
No abstract text is available yet for this article.
February 3, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29427722/effect-of-argemone-mexicana-active-principles-on-inhibiting-viral-multiplication-and-stimulating-immune-system-in-pacific-white-leg-shrimp-litopenaeus-vannamei-against-white-spot-syndrome-virus
#11
Pandi Palanikumar, Dani Joel Daffni Benitta, Chinnadurai Lelin, Eswaramoorthy Thirumalaikumar, Mariavincent Michaelbabu, Thavasimuthu Citarasu
Argemone mexicana called as Mexican prickly poppy is a species of poppy found in Mexico and now widely naturalized in many parts of the world with broad range of bioactivities including anthelmintic, cures lepsory, skin-diseases, inflammations and bilious fevers. Plant parts of A. mexicana were serially extracted with hexane, ethyl acetate, methanol and performed antiviral and immunostimulant screening against WSSV and Vibrio harveyi respectively. The control groups succumbed to death 100% within three days, whereas the mortality was significantly (P < 0...
February 7, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29421665/inhaled-hexadecyl-treprostinil-provides-pulmonary-vasodilator-activity-at-significantly-lower-plasma-concentrations-than-infused-treprostinil
#12
Richard W Chapman, Zhili Li, Michel R Corboz, Helena Gauani, Adam J Plaunt, Donna M Konicek, Franziska G Leifer, Charles E Laurent, Han Yin, Dany Salvail, Chad Dziak, Walter R Perkins, Vladimir Malinin
INS1009 is a long acting pulmonary vasodilator prodrug of treprostinil (TRE) that is formulated in a lipid nanoparticle for inhaled delivery by nebulization. This study examined the ability of INS1009 to inhibit vasoconstriction in the pulmonary vasculature of rats and dogs and the extent to which local activity within the lung contributes to its activity. Rats received a single dose of INS1009 by nose-only inhalation or were given a continuous intravenous (i.v.) infusion of TRE, followed by an i.v. challenge of the thromboxane mimetic pulmonary vasoconstrictor U46619 and the increase in pulmonary arterial pressure (PAP) was measured...
February 5, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29420752/the-significance-of-human-spermatozoa-vacuoles-can-be-elucidated-by-a-novel-procedure-of-array-comparative-genomic-hybridization
#13
Arie Berkovitz, Yaron Dekel, Revital Goldstein, Shhadeh Bsoul, Yossy Machluf, Dani Bercovich
STUDY QUESTION: Is there an association between spermatozoon genomic stability and vacuolar morphology and location? SUMMARY ANSWER: The genomic stability of spermatozoa is associated with specific characteristics of vacuolar morphology (depth) and location (cellular compartment, i.e. nucleus and equatorial region). WHAT IS KNOWN ALREADY: Genetic anomalies in sperm are correlated with semen abnormalities, yet the advantage of morphologically based selection of spermatozoa for IVF according to current criteria is controversial...
February 6, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29419464/muscle-strength-and-muscle-endurance-during-the-first-year-of-treatment-of-polymyositis-and-dermatomyositis-a-prospective-study
#14
Helene Alexanderson, Malin Regardt, Christina Ottosson, Li Alemo Munters, Maryam Dastmalchi, Lara Dani, Ingrid E Lundberg
OBJECTIVE: To investigate muscle impairment (isometric and dynamic) and disease activity during the first year after diagnosis of polymyositis (PM) and dermatomyositis (DM), and to study the relationship between muscle impairment, patient-reported health, and disease activity. METHODS: Seventy-two patients enrolled in the Swedish Myositis Register, 2003-2010, were followed prospectively. The Manual Muscle test (MMT-8; isometric muscle strength), the Functional Index of myositis test (FI-2; dynamic, repetitive muscle function), and disease activity (6-item core set) were retrieved at the time of diagnosis, and after 6 and 12 months...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419452/dr-guerra-et-al-reply
#15
Federico Guerra, Chiara Gelardi, Alessandro Capucci, Armando Gabrielli, Maria Giovanna Danieli
No abstract text is available yet for this article.
February 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29416285/a-rare-case-of-renal-vein-thrombosis-secondary-to-klebsiella-pneumoniae-pyelonephritis
#16
Kelly L Lurz, Dany N Hanna, Brian H McGreen, Francis J Schanne
Renal vein thrombosis (RVT) is most often an implication of nephrotic syndrome. Pyelonephritis has been associated at a much lower rate, with the incidence of Klebsiella pneumoniae causation being extremely rare. In our case, a 35-year-old female patient presented with right-sided K. pneumoniae-positive acute pyelonephritis complicated by perinephric abscess and renal vein thrombosis. She was successfully treated with anticoagulation and extended antibiotic therapy. The possibility of RVT in patients with K...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29411158/topically-applied-ceramides-interact-with-the-stratum-corneum-lipid-matrix-in-compromised-ex-vivo-skin
#17
Tineke Berkers, Dani Visscher, Gert S Gooris, Joke A Bouwstra
PURPOSE: To determine whether formulations containing ceramides (including a ceramide with a long hydroxyl acyl chain linked to a linoleate, CER EOS) and fatty acids are able to repair the skin barrier by normalizing the lipid organization in stratum corneum (SC). METHODS: The formulations were applied on a skin barrier repair model consisting of ex vivo human skin from which SC was removed by stripping. The effect of formulations on the lipid organization and conformational ordering in the regenerated SC were analyzed using Fourier transform infrared spectroscopy and small angle X-ray diffraction...
February 6, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29410689/comparison-of-longitudinal-excursion-of-a-nerve-phantom-model-using-quantitative-ultrasound-imaging-and-motion-analysis-system-methods-a-convergent-validity-study
#18
Philippe Paquette, Youssef El Khamlichi, Martin Lamontagne, Johanne Higgins, Dany H Gagnon
Background: Quantitative ultrasound imaging is gaining popularity in research and clinical settings to measure the neuromechanical properties of the peripheral nerves such as their capability to glide in response to body segment movement. Increasing evidence suggests that impaired median nerve longitudinal excursion is associated with carpal tunnel syndrome. To date, psychometric properties of longitudinal nerve excursion measurements using quantitative ultrasound imaging have not been extensively investigated...
August 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29408731/neuronal-specific-impairment-of-heparan-sulfate-degradation-in-drosophila-reveals-pathogenic-mechanisms-for-mucopolysaccharidosis-type-iiia
#19
Dani L Webber, Amanda Choo, Laura J Hewson, Paul J Trim, Marten F Snel, John J Hopwood, Robert I Richards, Kim M Hemsley, Louise V O'Keefe
Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder resulting from the deficit of the N-sulfoglucosamine sulfohydrolase (SGSH) enzyme that leads to accumulation of partially-degraded heparan sulfate. MPS IIIA is characterized by severe neurological symptoms, clinically presenting as Sanfilippo syndrome, for which no effective therapy is available. The lysosomal SGSH enzyme is conserved in Drosophila and we have identified increased levels of heparan sulfate in flies with ubiquitous knockdown of SGSH/CG14291...
February 1, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29408716/scanning-fiber-endoscope-improves-detection-of-5-ala-induced-protoporphyrin-ix-fluorescence-at-the-boundary-of-infiltrative-glioma
#20
Evgenii Belykh, Eric J Miller, Danying Hu, Nikolay L Martirosyan, Eric C Woolf, Adrienne C Scheck, Vadim A Byvaltsev, Peter Nakaji, Leonard Y Nelson, Eric J Seibel, Mark C Preul
OBJECTIVE: Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas. Current wide-field imaging technologies do not have sufficient sensitivity to detect low PpIX concentrations. We evaluated a scanning fiber endoscope (SFE) for detection of PpIX fluorescence in gliomas and compared it with an operating microscope (OPMI) equipped with fluorescence module and a benchtop confocal laser scanning microscope (CLSM)...
January 31, 2018: World Neurosurgery
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