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https://www.readbyqxmd.com/read/28734171/muscle-synergies-reveal-impaired-trunk-muscle-coordination-strategies-in-individuals-with-thoracic-spinal-cord-injury
#1
Matija Milosevic, Hikaru Yokoyama, Murielle Grangeon, Kei Masani, Milos R Popovic, Kimitaka Nakazawa, Dany H Gagnon
Spinal cord injury (SCI) can result in paralysis of trunk muscles, which can affect sitting balance. The objective of this study was to analyze trunk muscle coordination of individuals with thoracic SCI and compare it to able-body individuals. A total of 27 individuals were recruited and subdivided into: (a) high thoracic SCI; (b) low thoracic SCI; and (c) able-body groups. Participants were seated and asked to lean their trunk in eight directions while trunk muscle activity was recorded. Muscle coordination was assessed using the non-negative matrix factorization (NMF) method to extract muscle modules, which are the synergistic trunk muscle activations, and their directional activation patterns...
July 1, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28728140/effects-of-inorganic-arsenic-methylated-arsenicals-and-arsenobetaine-on-atherosclerosis-in-the-mouse-model-and-the-role-of-as3mt-mediated-methylation
#2
Luis Fernando Negro Silva, Maryse Lemaire, Catherine A Lemarié, Dany Plourde, Alicia M Bolt, Christopher Chiavatti, D Scott Bohle, Vesna Slavkovich, Joseph H Graziano, Stéphanie Lehoux, Koren K Mann
BACKGROUND: Arsenic is metabolized through a series of oxidative methylation reactions by arsenic (3) methyltransferase (As3MT) to yield methylated intermediates. Although arsenic exposure is known to increase the risk of atherosclerosis, the contribution of arsenic methylation and As3MT remains undefined. OBJECTIVES: Our objective was to define whether methylated arsenic intermediates were proatherogenic and whether arsenic biotransformation by As3MT was required for arsenic-enhanced atherosclerosis...
July 5, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28721437/erk1-is-dispensable-for-mouse-pancreatic-beta-cell-function-but-is-necessary-for-glucose-induced-full-activation-of-msk1-and-creb
#3
Michele Leduc, Joy Richard, Safia Costes, Dany Muller, Annie Varrault, Vincent Compan, Julia Mathieu, Jean-François Tanti, Gilles Pagès, Jacques Pouyssegur, Gyslaine Bertrand, Stéphane Dalle, Magalie A Ravier
AIMS/HYPOTHESIS: Insufficient insulin secretion from pancreatic beta cells, which is associated with a decrease in beta cell mass, is a characteristic of type 2 diabetes. Extracellular signal-related kinase 1 and 2 (ERK1/2) inhibition in beta cells has been reported to affect insulin secretion, gene transcription and survival, although whether ERK1 and ERK2 play distinct roles is unknown. The aim of this study was to assess the individual roles of ERK1 and ERK2 in beta cells using ERK1 (also known as Mapk3)-knockout mice (Erk1 (-/-) mice) and pharmacological approaches...
July 18, 2017: Diabetologia
https://www.readbyqxmd.com/read/28718888/assessing-lung-function-using-contrast-enhanced-dual-energy-computed-tomography-for-potential-applications-in-radiation-therapy
#4
Andréanne Lapointe, Houda Bahig, Danis Blais, Hugo Bouchard, Édith Filion, Jean-François Carrier, Stéphane Bedwani
PURPOSE: There is an increasing interest in the evaluation of lung function from physiological images in radiation therapy treatment planning to reduce the extent of post-radiation toxicities. The purpose of this work is to retrieve reliable functional information from contrast-enhanced dualenergy computed tomography (DECT) for new applications in radiation therapy. The functional information obtained by DECT is also compared with other methods using single energy CT (SECT) and single-photon emission computed tomography (SPECT) with CT...
July 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28717763/burkitt-s-lymphoma-and-b-cell-lymphoma-unclassifiable-with-features-intermediate-between-diffuse-large-b-cell-lymphoma-and-burkitt-s-lymphoma-in-patients-with-hiv-outcomes-in-a-south-african-public-hospital
#5
Gerhard Sissolak, Matthew Seftel, Thomas S Uldrick, Tonya M Esterhuizen, Nooroudien Mohamed, Danie Kotze
PURPOSE: Burkitt's lymphoma (BL) is a common HIV-associated lymphoma in South Africa. B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt's lymphoma (BL/DLBCL) also occurs in HIV infection. Outcomes of HIV-infected patients with BL or BL/DLBCL in a resource-constrained setting are not defined. METHODS: We performed a retrospective study of HIV-positive patients with BL or BL/DLBCL treated from 2004 to 2012 with curative intent at a publically funded academic medical center in South Africa...
June 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28715877/prognostic-value-of-transglutaminase-2-in-non-small-cell-lung-cancer-patients
#6
Zhu Chihong, Ling Yutian, Wan Danying, Jiang Ruibin, Sheng Huaying, Gu Linhui, Feng Jianguo
Transglutaminase 2 (TG2) plays important roles in cell survival and cancer progression. In this study, we examined TG2 expression in specimen of 194 patients diagnosed with non-small cell lung cancer (NSCLC), and found that the TG2 gene expression was significantly higher in lung cancer tissues as compared to paired incisal marginal tissues or normal tissues. Our data revealed that patients with lower level of TG2 expression detected in cancer tissues had longer disease free survival and overall survival as compared to the patients with higher TG2 expression...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28715302/characterization-of-humeral-head-displacements-during-dynamic-glenohumeral-neuromuscular-control-exercises-using-quantitative-ultrasound-imaging-a-feasibility-study
#7
Guillaume Desroches, François Desmeules, Dany H Gagnon
The objectives of the present study were to test the feasibility of measuring humeral head displacements using quantitative ultrasound imaging during the performance of two different dynamic glenohumeral neuromuscular control exercises and to investigate the influence of these exercises on the acromiohumeral distance (AHD) and anterior-posterior distance (APD). Ten individuals who have no history of shoulder injury at the non-dominant shoulder completed three repetitions of an active humeral head lowering exercise and three repetitions of a posteriorisation exercise in a random order in a seated position...
June 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28714234/an-improved-correlation-to-predict-molecular-weight-between-crosslinks-based-on-equilibrium-degree-of-swelling-of-hydrogel-networks
#8
Andrea C Jimenez-Vergara, John Lewis, Mariah S Hahn, Dany J Munoz-Pinto
Accurate characterization of hydrogel diffusional properties is of substantial importance for a range of biotechnological applications. The diffusional capacity of hydrogels has commonly been estimated using the average molecular weight between crosslinks (Mc ), which is calculated based on the equilibrium degree of swelling. However, the existing correlation linking Mc and equilibrium swelling fails to accurately reflect the diffusional properties of highly crosslinked hydrogel networks. Also, as demonstrated herein, the current model fails to accurately predict the diffusional properties of hydrogels when polymer concentration and molecular weight are varied simultaneously...
July 17, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28712728/hexim1-and-neat1-long-non-coding-rna-form-a-multi-subunit-complex-that-regulates-dna-mediated-innate-immune-response
#9
Mehdi Morchikh, Alexandra Cribier, Raoul Raffel, Sonia Amraoui, Julien Cau, Dany Severac, Emeric Dubois, Olivier Schwartz, Yamina Bennasser, Monsef Benkirane
The DNA-mediated innate immune response underpins anti-microbial defenses and certain autoimmune diseases. Here we used immunoprecipitation, mass spectrometry, and RNA sequencing to identify a ribonuclear complex built around HEXIM1 and the long non-coding RNA NEAT1 that we dubbed the HEXIM1-DNA-PK-paraspeckle components-ribonucleoprotein complex (HDP-RNP). The HDP-RNP contains DNA-PK subunits (DNAPKc, Ku70, and Ku80) and paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATRIN3). We show that binding of HEXIM1 to NEAT1 is required for its assembly...
July 10, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28711775/natural-and-artificial-radionuclides-in-sludge-sand-granular-activated-carbon-and-reverse-osmosis-brine-from-a-metropolitan-drinking-water-treatment-plant
#10
Dani Mulas, Antonia Camacho, Isabel Serrano, Sergio Montes, Ricard Devesa, Maria Amor Duch
No abstract text is available yet for this article.
July 13, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28709247/intermittent-many-body-dynamics-at-equilibrium
#11
C Danieli, D K Campbell, S Flach
The equilibrium value of an observable defines a manifold in the phase space of an ergodic and equipartitioned many-body system. A typical trajectory pierces that manifold infinitely often as time goes to infinity. We use these piercings to measure both the relaxation time of the lowest frequency eigenmode of the Fermi-Pasta-Ulam chain, as well as the fluctuations of the subsequent dynamics in equilibrium. The dynamics in equilibrium is characterized by a power-law distribution of excursion times far off equilibrium, with diverging variance...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28703038/rehabilitation-interventions-to-modify-endocrine-metabolic-disease-risk-in-individuals-with-chronic-spinal-cord-injury-living-in-the-community-riisc-a-systematic-review-and-scoping-perspective
#12
Jenna C Gibbs, Dany H Gagnon, Austin J Bergquist, Jasmine Arel, Tomas Cervinka, Rasha El-Kotob, Désirée B Maltais, Dalton L Wolfe, B Catharine Craven
Context Endocrine-metabolic disease (EMD) risk following spinal cord injury (SCI) is associated with significant multi-morbidity (i.e. fracture, diabetes, heart disease), mortality, and economic burden. It is unclear to what extent rehabilitation interventions can modify EMD risk and improve health status in community-dwelling adults with chronic SCI. Objectives To characterize rehabilitation interventions and summarize evidence on their efficacy/effectiveness to modify precursors to EMD risk in community-dwelling adults with chronic SCI...
July 13, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28698159/identification-of-novel-and-hotspot-mutations-in-the-channel-domain-of-itpr1-in-two-patients-with-gillespie-syndrome
#13
M L Dentici, S Barresi, M Nardella, E Bellacchio, P Alfieri, A Bruselles, F Pantaleoni, A Danieli, G Iarossi, M Cappa, E Bertini, M Tartaglia, G Zanni
ITPR1 encodes an intracellular receptor for inositol 1,4,5-trisphosphate (InsP3) which is highly expressed in the cerebellum and is involved in the regulation of Ca2+ homeostasis. Missense mutations in the InsP3-binding domain (IRBIT) of ITPR1 are frequently associated with early onset cerebellar atrophy. Gillespie syndrome is characterized by congenital ataxia, mild to moderate intellectual disability and iris hypoplasia. Dominant or recessive ITPR1 mutations have been recently associated with this form of syndromic ataxia...
July 8, 2017: Gene
https://www.readbyqxmd.com/read/28695204/resolving-quanta-of-collective-spin-excitations-in-a-millimeter-sized-ferromagnet
#14
Dany Lachance-Quirion, Yutaka Tabuchi, Seiichiro Ishino, Atsushi Noguchi, Toyofumi Ishikawa, Rekishu Yamazaki, Yasunobu Nakamura
Combining different physical systems in hybrid quantum circuits opens up novel possibilities for quantum technologies. In quantum magnonics, quanta of collective excitation modes in a ferromagnet, called magnons, interact coherently with qubits to access quantum phenomena of magnonics. We use this architecture to probe the quanta of collective spin excitations in a millimeter-sized ferromagnetic crystal. More specifically, we resolve magnon number states through spectroscopic measurements of a superconducting qubit with the hybrid system in the strong dispersive regime...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28692217/-magnesium-in-daily-practice
#15
Dany Minetto, Jacques Serratrice, Jérôme Stirnemann
The magnesium is the 4th cation in the human body behind sodium, potassium and calcium. It is often referred to as the forgotten cation of modern medicine because of a lack of knowledge about its physiology and its potential medical use. Recent medical literature has shown renewed interest for the magnesium with publications about its role in diversified fields from prevention of muscular cramps, cardiovascular risk factors prevention trough to neuroprotection in stroke. However, we cannot recommend the use of magnesium in adults in our clinical practice, beyond the simple correction of hypomagnesemia, pre-eclampsia and possibly the treatment of torsades de pointes...
October 19, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28691852/express-the-importance-of-interactions-at-the-molecular-level-spectroscopic-study-of-a-new-composite-sorber-material
#16
Paolo Vacca, Stefano Zilio, Agnello De SImone, Valentina Crocellà, Elena Groppo, SIlvia Bordiga, Alessandro Dani, Alberto Castellero
No abstract text is available yet for this article.
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28689559/lactation-skills-workshop-a-collaboration-of-the-city-of-dallas-wic-and-local-hospitals
#17
Janice Ballou, Christine Wiseman, Linda Jackson, Reba Godfrey, Dani Cagle
The Baby-Friendly Hospital Initiative, a global endeavor of the World Health Organization and the United Nations Children's Fund, is an evidence-based program identifying 10 interventions that when hospitals implement them, breastfeeding (BF) rates improve. It recognizes the powerful role that health care workers have in successful BF and the need for competent hands-on skills to support lactation. The City of Dallas, TX, Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) program collaborated with 3 urban hospitals and developed a training of practical techniques and information for staff to use while working with BF patients...
July 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28686091/correlation-between-the-position-of-hyoid-bone-and-subregions-of-the-pharyngeal-airway-space-in-lateral-cephalometry-and-cone-beam-computed-tomography
#18
Eliana Dantas da Costa, Gina Delia Roque-Torres, Danieli Moura Brasil, Frab Noberto Bóscolo, Solange Maria de Almeida, Glaucia Maria Bovi Ambrosano
OBJECTIVE: To correlate the pharyngeal airway subregions with the positioning of the hyoid bone. MATERIAL AND METHODS: The study examined 107 lateral cephalometric (LC) and cone beam computed tomography (CBCT) images. Linear and volumetric measurements of the pharyngeal subregions were made and correlated to linear measurements using hyoid triangle analysis on images of LC and multiplanar (MPR) and three-dimensional (3D) reconstructions of CBCT. RESULTS: There was significant correlation between linear measurements of the pharyngeal subregions and hyoid bone position in LC images and in MPR and 3D reconstructions of the CBCT...
July 7, 2017: Angle Orthodontist
https://www.readbyqxmd.com/read/28681062/use-of-molecular-biology-techniques-in-sarcoidal-granulomatous-dermatitis-a-clinicopathological-and-molecular-approach-with-diagnostic-implications
#19
Tiago C Esteves, Teresa Tórtola, Berta Ferrer, Gloria Aparicio, Elena Sulleiro, Juanjo González-López, Zaira Moure, Dani Romero, Vicente Garcia-Patos
No abstract text is available yet for this article.
July 6, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28679662/measuring-the-plasmodium-falciparum-hrp2-protein-in-blood-from-artesunate-treated-malaria-patients-predicts-post-artesunate-delayed-hemolysis
#20
Papa Alioune Ndour, Sébastien Larréché, Oussama Mouri, Nicolas Argy, Frédérick Gay, Camille Roussel, Stéphane Jauréguiberry, Claire Perillaud, Dominique Langui, Sylvestre Biligui, Nathalie Chartrel, Audrey Mérens, Eric Kendjo, Aniruddha Ghose, Md Mahtab Uddin Hassan, Md Amir Hossain, Hugh W F Kingston, Katherine Plewes, Arjen M Dondorp, Martin Danis, Sandrine Houzé, Serge Bonnefoy, Marc Thellier, Charles J Woodrow, Pierre A Buffet
Artesunate, the recommended drug for severe malaria, rapidly clears the malaria parasite from infected patients but frequently induces anemia-called post-artesunate delayed hemolysis (PADH)-for which a simple predictive test is urgently needed. The underlying event in PADH is the expulsion of artesunate-exposed parasites from their host erythrocytes by pitting. We show that the histidine-rich protein 2 (HRP2) of the malaria parasite Plasmodium falciparum persists in the circulation of artesunate-treated malaria patients in Bangladesh and in French travelers who became infected with malaria in Africa...
July 5, 2017: Science Translational Medicine
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