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Joseph Ben-Sheetrit, Miriam Peskin, Jeffrey H Newcorn, Yaron Daniely, Liat Shbiro, Ann Rotem, Abraham Weizman, Iris Manor
OBJECTIVE: Several ADHD pharmacological trials reported high placebo response (PR) rates. This study aims to characterize the PR in adult ADHD. METHOD: A retrospective cohort analysis of the placebo arm (140 adults with ADHD, 18-55 yrs, M:F 46.4%-53.6%) of a 6-week randomized, multicenter, double-blind metadoxine study, using Conners' Adult ADHD Rating Scale (CAARS) and the Adult ADHD Self-Report Scale (ASRS), was conducted. RESULTS: Pre-post changes in placebo-treated adults were significant for both the CAARS and ASRS, F(2...
June 1, 2018: Journal of Attention Disorders
Giuseppe Regolisti, Umberto Maggiore, Alice Sabatino, Ilaria Gandolfini, Sarah Pioli, Claudia Torino, Filippo Aucella, Adamasco Cupisti, Valentina Pistolesi, Alessandro Capitanini, Giorgia Caloro, Mariacristina Gregorini, Yuri Battaglia, Marcora Mandreoli, Lucia Dani, Giovanni Mosconi, Vincenzo Bellizzi, Biagio Raffaele Di Iorio, Paolo Conti, Enrico Fiaccadori
[This corrects the article DOI: 10.1371/journal.pone.0196313.].
2018: PloS One
Maila Danielis, Sara Colussi, Carla de Leitenburg, Lluis Soler, Jordi Llorca, Alessandro Trovarelli
By carefully mixing Pd metal nanoparticles with CeO2 polycrystalline powder under dry conditions a new unpredicted arrangement of the Pd-O-Ce interface is obtained, where an amorphous shell containing Palladium species dissolved in Ceria is covering a core of CeO2 particles. The robust contact that is generated at nanoscale, along with mechanical forces generated during mixing, promotes the redox exchange between Pd and CeO2 and creates highly reactive and stable sites constituted by PdOx embedded into CeO2 surface layers...
June 20, 2018: Angewandte Chemie
Nency Khant, Vyoma Bharat Dani, Purvi Patel, Rachana Rathod
CONTEXT: Timed up-and-go (TUG) test is a valid, reliable, and an objective test for quantifying functional mobility and assessing the fall risk in all age groups. The analysis of patient scores on TUG test is limited by lack of data, having a wide range of performance scores among people without disabilities. AIM: The objective of the study was to provide the reference value for TUG test in healthy individuals of Gujarat, India. SUBJECTS AND METHODS: It was a cross-sectional observational study...
2018: Journal of Education and Health Promotion
Marie-Anastasie Aim, Solveig Lelaurain, Nicolas Khatmi, David Fonte, Inna Bovina, Lionel Dany
This study focuses on life experiences and social representations related to gender in the context of health among young French lay people aged from 18 to 21 years ( N = 47). Qualitative analysis of the discursive content of nine focus groups illuminated the lay thinking underlying gender issues in the health context. Broadly speaking, group composition (i.e. unisex, mixed) had an impact on participants' discourse construction. Through their discourses, participants came to 'naturalise' the health issues and practices of each sex/gender through the biological specificities of men and women...
June 1, 2018: Journal of Health Psychology
Irit Zohar, Tamar Dayan, Menachem Goren, Dani Nadel, Israel Hershkovitz
Analysis of ca. 17,000 fish remains recovered from the late Upper Paleolithic/early Epi-Paleolithic (LGM; 23,000 BP) waterlogged site of Ohalo II (Rift Valley, Israel) provides new insights into the role of wetland habitats and the fish inhabiting them during the evolution of economic strategies prior to the agricultural evolution. Of the current 19 native fish species in Lake Kinneret (Sea of Galilee), eight species were identified at Ohalo II, belonging to two freshwater families: Cyprinidae (carps) and Cichlidae (St...
2018: PloS One
François Barbier, Sébastien Bailly, Carole Schwebel, Laurent Papazian, Élie Azoulay, Hatem Kallel, Shidasp Siami, Laurent Argaud, Guillaume Marcotte, Benoît Misset, Jean Reignier, Michaël Darmon, Jean-Ralph Zahar, Dany Goldgran-Toledano, Étienne de Montmollin, Bertrand Souweine, Bruno Mourvillier, Jean-Francois Timsit
The members of the OUTCOMEREA Study Group were provided in such a way that they could not be indexed as collaborators on PubMed. The publisher apologizes for this error and is pleased to list the members of the group here.
June 15, 2018: Intensive Care Medicine
Mayank Jain, Mahadevan Balkrishanan, Chenduran Snk, Sridhar Cgs, Ravi Ramakrishnan, Jayanthi Venkataraman
We report our experience of three cases of decompensated cirrhosis with massive upper gastrointestinal bleeding, which required insertion of an SX-Ella Danis stent for hemostasis. The procedure is safe and effective.
June 2018: Clinical and Experimental Hepatology
Dani Permana, Kosuke Minamihata, Masahiro Goto, Noriho Kamiya
The site-specific cross-linking of functional proteins creates macromolecular assemblies that exhibit unique biochemical and/or physicochemical properties. Herein, we explored the potential of laccase as a biocatalyst for the site-specific cross-linking of tyrosine-tagged proteins. Trametes sp. laccase (TL) was selected as the cross-linking catalyst, and Escherichia coli alkaline phosphatase (BAP) and antibody-binding proteins (pG2 pAs) were employed as model proteins. The protein models were genetically fused to a peptide tag containing a tyrosine residue (Y-tag) at the N- and/or C-termini...
June 12, 2018: Journal of Bioscience and Bioengineering
Danying Wang, Andrew Clouter, Qiaoyu Chen, Kimron L Shapiro, Simon Hanslmayr
Episodic memories are rich in sensory information and often contain integrated information from different sensory modalities. For instance, we can store memories of a recent concert with visual and auditory impressions being integrated in one episode. Theta oscillations have recently been implicated in playing a causal role synchronizing and effectively binding the different modalities together in memory. However, an open question is whether momentary fluctuations in theta synchronization predict the likelihood of associative memory formation for multisensory events...
June 13, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Claudia Cristina Biguetti, Franco Cavalla, Elcia M Silveira, Angélica Cristina Fonseca, Andreia Espindola Vieira, Andre Petenuci Tabanez, Danieli C Rodrigues, Ana Paula Favaro Trombone, Gustavo Pompermaier Garlet
INTRODUCTION: Despite the successful clinical application of titanium (Ti) as a biomaterial, the exact cellular and molecular mechanisms responsible for Ti osseointegration remains unclear, especially because of the limited methodological tools available in this field. OBJECTIVE: In this study, we present a microscopic and molecular characterization of an oral implant osseointegration model using C57Bl/6 mice. MATERIAL AND METHODS: Forty-eight male wild-type mice received a Ti implant on the edentulous alveolar crest and the peri-implant sites were evaluated through microscopic (μCT, histological and birefringence) and molecular (RealTimePCRarray) analysis in different points in time after surgery (3, 7, 14 and 21 days)...
June 11, 2018: Journal of Applied Oral Science: Revista FOB
Ruy José V Alves, Marcelo Weksler, João A Oliveira, Paulo A Buckup, José P Pombal, Hélcio R G Santana, Adriano Lúcio Peracchi, Alexander W A Kellner, Alexandre Aleixo, Alfredo Ricardo L Bonino, Alzira Maria P DE Almeida, Ana Luisa Albernaz, Camila C Ribas, Carla Zilberberg, Carlos Eduardo V Grelle, Carlos Frederico D DA Rocha, Carlos José E Lamas, Célio Fernando B Haddad, Cibele R Bonvicino, Cynthia P A Prado, Daniela O DE Lima, Denise C Rossa-Feres, Fabrício R Dos Santos, Fátima Regina G Salimena, Fernando A Perini, Flávio A Bockmann, Francisco Luís Franco, Gisele M L Del Giudice, Guarino R Colli, Ima Célia G Vieira, Jader Marinho-Filho, Jane M C F Werneck, Jorge A D Dos Santos, Jorge Luiz DO Nascimento, Jorge Luiz Nessimian, José Luis P Cordeiro, Kleber Del Claro, Leandro O Salles, Lilian Casatti, Lucia Helena R Py-Danie, Luís Fábio Silveira, Luís Felipe Toledo, Luiz F DE Oliveira, Luiz Roberto Malabarba, Marcelo D DA Silva, Márcia S Couri, Márcio R C Martins, Marcos D S Tavares, Marcos Eduardo G Sobral, Marcus Vinícius Vieira, Maria DE Lourdes A Oliveira, Mário César C DE Pinna, Michael J G Hopkins, Mirco Solé, Naércio A Menezes, Paulo Passos, Paulo Sergio D'Andrea, Pedro C E A Pinto, Pedro L Viana, Peter M Toledo, Roberto E Dos Reis, Roberto Vilela, Rogério P Bastos, Rosane G Collevatti, Rui C Silva, Santiago C Fisher, Ulisses Caramaschi
No abstract text is available yet for this article.
April 2018: Anais da Academia Brasileira de Ciências
Tarek Alhamad, John Manllo Dieck, Usman Younus, Dany Matar, Sami Alasfar, Vikas Vujjini, Devin Wall, Bilal Kanawati, Reiser Jochen, Daniel C Brennan, Nada Alachkar
BACKGROUND: Treatment of focal segmental glomerular sclerosis (FSGS) after kidney transplantation is challenging with unpredictable outcomes. The objective was to investigate the use of adrenocorticotropic hormone (ACTH) analogue gel in kidney transplant recipients with de novo or recurrent FSGS resistant to therapeutic plasma exchange and/or rituximab. METHODS: We performed a retrospective review of cases of de novo or recurrent resistant FSGS at 2 large U.S. transplant centers between April 2012 and December 2016...
June 12, 2018: Transplantation
Magali Giral, Karine Renaudin, Maarten Naesens, Redmer Luning, Dany Anglicheau, Emmanuel Morelon, Alexandre Huneau, Chloé Paul, Sophie Brouard, Grégoire Couvrat-Desvergnes, Yohann Foucher, Etienne Dantan
Surveillance biopsies after renal transplantation remain debatable. To drive the decision of such intervention, we propose a predictive score of abnormal histology at 1-year post-transplantation, named 1-Year Renal Biopsy Index (1-RBI). We studied 466 kidney recipients from the DIVAT cohort alive with a functioning graft and a surveillance biopsy at 1-year post-transplantation. Patients displaying abnormal histology (49%) (borderline, acute rejection, IFTA grade 2 or 3, glomerulonephritis) were compared to the normal or subnormal (IFTA grade 1) histology group...
June 12, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Laurent Remontet, Zoé Uhry, Nadine Bossard, Jean Iwaz, Aurélien Belot, Coraline Danieli, Hadrien Charvat, Laurent Roche
Cancer survival trend analyses are essential to describe accurately the way medical practices impact patients' survival according to the year of diagnosis. To this end, survival models should be able to account simultaneously for non-linear and non-proportional effects and for complex interactions between continuous variables. However, in the statistical literature, there is no consensus yet on how to build such models that should be flexible but still provide smooth estimates of survival. In this article, we tackle this challenge by smoothing the complex hypersurface (time since diagnosis, age at diagnosis, year of diagnosis, and mortality hazard) using a multidimensional penalized spline built from the tensor product of the marginal bases of time, age, and year...
January 1, 2018: Statistical Methods in Medical Research
Robin G Lorenz, Donald S Karcher, Michael D Gautreaux, Melvin Limson, Dani S Zander
There has been a recent recognition of the need to prepare PhD-trained scientists for increasingly diverse careers in academia, industry, and health care. The PhD Data Task Force was formed to better understand the current state of PhD scientists in the clinical laboratory workforce and collect up-to-date information on the training and certification of these laboratorians. In this report, we summarize the findings of the PhD Data Task Force and discuss the relevance of the data collected to the future supply of and demand for PhD clinical laboratory scientists...
January 2018: Academic Pathology
Cindy Gauthier, Rachel Brosseau, Audrey L Hicks, Dany H Gagnon
Objectives: To investigate and compare the feasibility, safety, and preliminary effectiveness of home-based self-managed manual wheelchair high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) programs. Methods: Eleven manual wheelchair users were randomly assigned to the HIIT ( n = 6) or the MICT group ( n = 5). Both six-week programs consisted of three 40-minute propulsion training sessions per week. The HIIT group alternated between 30 s high-intensity intervals and 60 s low-intensity intervals, whereas the MICT group maintained a constant moderate intensity...
2018: Rehabilitation Research and Practice
Vincent J Santora, Theresa A Almos, Richard Barido, Jillian Basinger, Chris L Bellows, Brett Carder Bookser, J Guy Breitenbucher, Nicola J Broadbent, Clifford Cabebe, Chih-Kun Chai, Mi Chen, Stephine Chow, De Michael Chung, Lindsay Crickard, Anne M Danks, Graeme Freestone, Dany Gitnick, Varsha Gupta, Christine Hoffmaster, Andrew R Hudson, Alan P Kaplan, Michael R Kennedy, Dong Lee, James Limberis, Kiev Ly, Chi Ching Mak, Brittany Masatsugu, Andrew C Morse, Jim Na, David Neul, John Nikpur, Marco Peters, Robert E Petroski, Joel Renick, Kristen Sebring, Samantha Sevidal, Ali Tabatabaei, Jenny Wen, Yingzhuo Yan, Zachary W Yoder, Douglas Zook
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4-c]pyrazoles amides (21-50) with good in vitro potency. Subsequent optimization of physicochemical and in vitro ADME properties produced several compounds with promising pharmacokinetic profiles. In vivo inhibition of GlyT1 was demonstrated for select compounds within this series by measuring the elevation of glycine in the cerebrospinal fluid (CSF) of rats after a single oral dosing of 10 mg/kg...
June 11, 2018: Journal of Medicinal Chemistry
Jianchun Yu, Xing Chen, Danying Zhou, Jian Shen, Yanbing Wu, Qingzhu Sun
BACKGROUND Currently, safe and effective surgical treatment of malignant glaucoma is still under investigation. This study evaluated the clinical efficacy of ciliary ring incision combined with modified partial pars plana vitrectomy in the treatment of malignant glaucoma. The technique is particularly useful in the treatment of "phakic" patients with malignant glaucoma, especially those who wish to preserve the natural lens. MATERIAL AND METHODS We retrospectively analyzed 13 cases (16 eyes) of malignant glaucoma in which patients underwent ciliary ring incision combined with modified partial pars plana vitrectomy based on follow-up data collected from May 2004 to March 2017...
June 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Sharon Gabison, Sunita Mathur, Mary C Verrier, Ethne Nussbaum, Milos R Popovic, Dany H Gagnon
BACKGROUND: Characterization of ischial tissue health using a standardized diagnostic ultrasound protocol capturing thickness and gray scale analysis has not been established. OBJECTIVES: This study evaluates inter-participant and inter-trial reliability of thickness and gray scale analysis of ultrasound images of tissues overlying the ischial tuberosity. It provides recommendations for the number of images required to minimize the standard error of measurement (SEM) and determines the number of images required for thickness, gray scale and contrast values that exceed an a-priori minimal detectable change (MDC) for repeated tissue assessment...
May 4, 2018: Journal of Tissue Viability
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