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https://www.readbyqxmd.com/read/28302284/hospital-based-screening-tools-in-the-identification-of-non-accidental-trauma
#1
Dani O Gonzalez, Katherine J Deans
Over 700,000 children are victims of abuse and neglect each year in the United States. Effective screening programs that entail broad capture of suspected non-accidental trauma (NAT) may help to identify sentinel injuries. This can facilitate earlier detection and psychosocial interventions in hopes of decreasing recurrent NAT, which confers a higher mortality rate. The purpose of this article is to outline essential components of hospital-based NAT screening tools and highlight existing programs. In general, these tools should include several components: education sessions for healthcare providers on how to identify signs of NAT, automated notes or checklists within the electronic medical record to prompt specialty referrals, and a multidisciplinary team of experts that can address the needs of these children in the acute care setting...
February 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/28301260/cancer-targeting-potential-of-99m-tc-finasteride-in-experimental-model-of-prostate-carcinogenesis
#2
Gowsia Jan, Neelima D Passi, Devinder Kumar Dhawan, Vijayta Dani Chadha
This study aimed to radiolabel finasteride, a novel 5α-reductase inhibitor, to evaluate its cancer targeting potential in experimental model of prostate carcinogenesis. Finasteride was effectively radiolabeled with (99m)Tc and showed >90% labeling efficiency. The radiopharmaceutical was found to be stable up to 6 hours in rat serum at 37°C. The blood kinetics of the (99m)Tc-finasteride followed a biphasic release pattern, whereby fast-release phase was observed at 15 seconds and a slow-release phase was observed after 30 minutes of administration...
March 2017: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28300181/damage-induced-cell-regeneration-in-the-midgut-of-aedes-albopictus-mosquitoes
#3
Maria Janeh, Dani Osman, Zakaria Kambris
Mosquito-transmitted diseases cause over one million deaths every year. A better characterization of the vector's physiology and immunity should provide valuable knowledge for the elaboration of control strategies. Mosquitoes depend on their innate immunity to defend themselves against pathogens. These pathogens are acquired mainly through the oral route, which places the insects' gut at the front line of the battle. Indeed, the epithelium of the mosquito gut plays important roles against invading pathogens acting as a physical barrier, activating local defenses and triggering the systemic immune response...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299373/examining-two-sets-of-introgression-lines-reveals-background-independent-and-stably-expressed-qtl-that-improve-grain-appearance-quality-in-rice-oryza-sativa-l
#4
Xianjin Qiu, Kai Chen, Wenkai Lv, Xiaoxue Ou, Yajun Zhu, Danying Xing, Longwei Yang, Fangjun Fan, Jie Yang, Jianlong Xu, Tianqing Zheng, Zhikang Li
A novel QTL cluster for appearance quality on Chr07 was identified using reciprocal introgression populations in different locations in China. Two secondary F 2 populations validated QTL with significant effect on appearance quality. Appearance quality (AQ) is the main determinants of market value of rice. Identification of QTL affecting AQ is the prerequisite for efficient improvement of AQ through marker-assisted selection (MAS). Two sets of reciprocal introgression lines derived from indica Minghui 63 and japonica 02428 were used to dissect the stability of QTL affecting five AQ traits, including grain length, grain width, length to width ratio, percentage of grains with chalkiness, and degree of endosperm chalkiness using 4568 bin genotype produced from 58,000 SNPs across five different environments...
March 15, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28298826/alveolar-ridge-preservation-using-autogenous-tooth-graft-versus-beta-tricalcium-phosphate-alloplast-a-randomized-controlled-prospective-clinical-pilot-study
#5
Chaitanya Pradeep Joshi, Nitin Hemchandra Dani, Smita Uday Khedkar
BACKGROUND: A randomized, prospective clinical, radiographical, and histological study was conducted to evaluate healing after alveolar ridge preservation technique using two different graft materials, namely, a novel autogenous graft material i. e., autogenous tooth graft (ATG) and beta-tricalcium phosphate (β-TCP) alloplast. MATERIALS AND METHODS: Fifteen patients undergoing extraction of at least three teeth were selected. Atraumatic extractions were performed...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28297644/dna-endonuclease-complex-dynamics-by-simultaneous-fret-and-fluorophore-intensity-in-evanescent-field
#6
Marijonas Tutkus, Tomas Marciulionis, Giedrius Sasnauskas, Danielis Rutkauskas
The single-molecule Förster resonance energy transfer (FRET) is a powerful tool to study interactions and conformational changes of biological molecules in the distance range from a few to 10 nm. In this study, we demonstrate a method to augment this range with longer distances. The method is based on the intensity changes of a tethered fluorophore, diffusing in the exponentially decaying evanescent excitation field. In combination with FRET it allowed us to reveal and characterize the dynamics of what had been inaccessible conformations of the DNA-protein complex...
March 14, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28296765/intermittent-pupillary-capture-of-intraocular-lens-after-transscleral-fixation-in-congenital-ectopia-lentis-patient-triggered-by-dark-environment-a-case-report
#7
Zhirong Wang, Qianzhong Cao, Guangming Jin, Charlotte Aimee Young, Yiyao Wang, Danying Zheng
RATIONALE: Although transscleral-fixated intraocular lens (IOL) implantation has been the most frequently chosen treatment for patients with inadequate capsule support, the ghost pupillary capture phenomenon did not cause enough attention. PATIENT CONCERNS: We present an unusual case withintermittent pupillary capture of intraocular lens. DIAGNOSIS: After 5 minutes staying in the dark environment, the pentacam examination revealed a mild nasal pupillary capture of the IOL...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295397/red-blood-cell-transfusions-can-induce-proinflammatory-cytokines-in-preterm-infants
#8
Carlo Dani, Chiara Poggi, Elena Gozzini, Valentina Leonardi, Alice Sereni, Rosanna Abbate, Anna Maria Gori
BACKGROUND: The risk of developing red blood cell (RBC) transfusion-associated necrotizing enterocolitis (TANEC) in preterm infants has recently been emphasized. Our aim was to assess changes in cytokine serum levels after RBC transfusions in a cohort of very preterm infants to evaluate their possible proinflammatory effect. STUDY DESIGN AND METHODS: We carried out a prospective observational study. One transfusion event was studied in infants less than 32 weeks' gestation and more than 7 days old (n = 20) admitted to a tertiary neonatal intensive care unit...
March 11, 2017: Transfusion
https://www.readbyqxmd.com/read/28292255/subcutaneous-igg-in-the-myositis-spectrum-disorders
#9
Maria Giovanna Danieli, Chiara Gelardi, Veronica Pedini, Francesco Logullo, Armando Gabrielli
The efficacy of subcutaneous immunoglobulin is reported in several neurological disorders and, more recently, its use has been extended to other inflammatory diseases, such as the idiopathic inflammatory myopathies, including polymyositis and dermatomyositis. Due to the rarity of these disorders, the role of immunoglobulin, administered intravenously or subcutaneously, remains unclear and poorly investigated. We report our experience about the use of subcutaneous immunoglobulin in myositis spectrum disorders, from idiopathic inflammatory myopathies to more complex conditions, such as overlap and cancer-associated myositis or pregnancy...
March 14, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28291241/efficacy-and-safety-of-direct-acting-antivirals-for-the-treatment-of-mixed-cryoglobulinemia
#10
Joel S Emery, Magdalena Kuczynski, Danie La, Saeed Almarzooqi, Matthew Kowgier, Hemant Shah, David Wong, Harry L A Janssen, Jordan J Feld
OBJECTIVES: Mixed cryoglobulinemia is strongly associated with hepatitis C virus (HCV) infection and ranges from being asymptomatic to causing life-threatening vasculitis. In those with symptoms, treatment with pegylated interferon (pegIFN) and ribavirin (RBV) reduces mortality. However, few data are available on the safety and efficacy of antiviral therapy with direct acting antivirals (DAAs) in the treatment of HCV-related cryoglobulinemia. METHODS: Patients treated for HCV-related cryoglobulinemia with DAA±pegIFN were retrospectively evaluated at a tertiary care center...
March 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28288605/switch-of-noninvasive-ventilation-niv-to-continuous-positive-airway-pressure-cpap-in-patients-with-obesity-hypoventilation-syndrome-a-pilot-study
#11
Sarah Orfanos, Dany Jaffuel, Christophe Perrin, Nicolas Molinari, Pascal Chanez, Alain Palot
BACKGROUND: Obesity is a major worldwide public health issue. The main respiratory complication stemming from obesity is obesity hypoventilation syndrome (OHS). Most of the OHS patients diagnosed during an exacerbation are treated with non invasive ventilation (NIV). Up to date, no prospective study has demonstrated in real life conditions the feasibility of a systematic protocoled switch of NIV to continuous positive airway pressure (CPAP), once stability is achieved. METHODS: In this prospective study, we included stable patients with OHS, with moderate to severe concomitant obstructive sleep apnea (OSA) and without obstructive pulmonary disease, who had been undergoing NIV for more than 2 months...
March 14, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28287954/refined-composite-multiscale-dispersion-entropy-and-its-application-to-biomedical-signals
#12
Hamed Azami, Mostafa Rostaghi, Dani Abasolo, Javier Escudero
OBJECTIVE: We propose a novel complexity measure to overcome the deficiencies of the widespread and powerful multiscale entropy (MSE), including, MSE values may be undefined for short signals, and MSE is slow for real-time applications. METHODS: We introduce multiscale dispersion entropy (DisEn - MDE) as a very fast and powerful method to quantify the complexity of signals. MDE is based on our recently developed DisEn, which has a computation cost of O(N), compared with O(N2) for sample entropy used in MSE...
March 8, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28285920/wide-scale-analysis-of-protein-expression-in-head-and-thorax-of-aedes-albopictus-females
#13
I Iovinella, B Caputo, A Della Torre, F R Dani
The recently available genome of Aedes albopictus - the most worldwide-spread human arbovirus vector - has revealed a large genome repertory and a great plasticity which are believed to have contributed to the species success as an invasive species and opened the way to genomic, transcriptomic and proteomic studies. We carried out the first wide-scale quantitative proteomic analysis of Ae. albopictus female head and thorax by means of a 'shotgun' approach based on nano liquid chromatography-high resolution mass spectrometry associated to protein Label Free Quantification (LFQ) which allows to assess differences in protein expression between tissues and different physiological stages...
March 9, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28284343/sphk1-mediates-neuroinflammation-and-neuronal-injury-via-traf2-nf-%C3%AE%C2%BAb-pathways-in-activated-microglia-in-cerebral-ischemia-reperfusion
#14
Danying Su, Yuefeng Cheng, Shi Li, Dawei Dai, Wei Zhang, Manhua Lv
Sphingosine kinase 1 (Sphk1), a key enzyme responsible for phosphorylating sphingosine into sphingosine1-phosphate (S1P), plays an important role in mediating post-stroke neuroinflammation. However, the pathway and mechanism of the Sphk1-mediated inflammatory response remains unknown. In this study, we found that suppression of Sphk1 decreased IL17 production and relieved neuronal damage induced by microglia in cerebral ischemia reperfusion (IR) or in an in vitro oxygen-glucose deprivation reperfusion (OGDR) system...
April 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28283789/cerebral-metabolic-changes-related-to-clinical-parameters-in-idiopathic-anosmic-patients-during-olfactory-stimulation-a-pilot-investigation
#15
Alessandro Micarelli, Agostino Chiaravalloti, Roberta Danieli, Orazio Schillaci, Marco Alessandrini
Idiopathic olfactory loss neural consequences have been studied especially by means of magnetic resonance imaging. Since other functional neuroimaging technique findings are lacking in the literature, present study used a validated (18)F-2-fluoro-2-deoxy-D-glucose (FDG) functional positron emission tomography procedure under olfactory stimulation (OS) to assess brain changes in idiopathic anosmic patients (IAPs) in comparison with healthy subjects (HS). A voxel-based analysis between these groups was used to evaluate FDG uptake in the brain and perform a correlation analysis between metabolic responses and the Sniffin' stick test as well as intensity visuo-analogue scores and disease duration (DD)...
March 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28282997/is-there-a-protective-role-of-testosterone-against-high-grade-prostate-cancer-incidence-and-severity-of-prostate-cancer-in-553-patients-who-underwent-prostate-biopsy-a-prospective-data-register
#16
Aksam Yassin, Mahmoud Salman, Riadh A Talib, Dany-Jan Yassin
This study investigated the role of testosterone replacement therapy (TRT) in prostate safety and cancer progression. A cohort of 553 patients, 42 treated and 162 untreated hypogonadal men, and 349 eugonadal men were included. Pathological analysis of prostate biopsies examining the incidence and severity of PCa revealed that: 16.7% of treated hypogonadal men had a positive biopsy, a Gleason score of ≤6 in 71.4% and >6 in 28.6% of men, a predominant score of 3 and tumour staging of II in 85.7% men; 51...
March 10, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28277952/agricultural-intensification-is-linked-to-constitutive-innate-immune-function-in-a-wild-bird-population
#17
Clarence Schmitt, Dany Garant, Marc Bélisle, Fanie Pelletier
Immunity represents an important defense mechanism against pathogens and is intimately linked to fitness. Previous studies have found significant interindividual variation of immune responses in wild populations and have emphasized the importance of ecological factors in explaining this variability. A deterioration of environmental conditions, such as agricultural intensification, can modify resource availability and, as a result, alter immune functions. The aim of this study was to investigate the effect of agricultural intensification on innate immune functions in breeding adult tree swallows (Tachycineta bicolor) over 6 yr...
March 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28276308/why-is-the-groundwater-level-rising-a-case-study-using-hartt-to-simulate-groundwater-level-dynamics
#18
Yohannes Yihdego Cara Danis Andrew Paffard
Groundwater from a shallow unconfined aquifer at a site in coastal New South Wales has been causing recent water logging issues. A trend of rising groundwater level has been anecdotally observed over the last 10 years. It was not clear whether the changes in groundwater levels were solely natural variations within the groundwater system or whether human interference was driving the level up. Time series topographic images revealed significant surrounding land use changes and human modification to the environment of the groundwater catchment...
February 24, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28275120/role-of-mgmt-methylation-status-at-time-of-diagnosis-and-recurrence-for-patients-with-glioblastoma-clinical-implications
#19
Alba A Brandes, Enrico Franceschi, Alexandro Paccapelo, Giovanni Tallini, Dario De Biase, Claudio Ghimenton, Daniela Danieli, Elena Zunarelli, Giovanni Lanza, Enrico Maria Silini, Carmelo Sturiale, Lorenzo Volpin, Franco Servadei, Andrea Talacchi, Antonio Fioravanti, Maria Pia Foschini, Stefania Bartolini, Annalisa Pession, Mario Ermani
BACKGROUND: MGMT methylation status represents a powerful prognostic factor in newly diagnosed glioblastoma (GBM). Recently, its role in recurrent tumors has also been suggested; however, few data investigating the stability of this biomarker during the clinical course of the disease are available. In this study, we evaluated the rate of change of MGMT methylation status between diagnosis and first recurrence in patients who received tumor resection for recurrent GBM. METHODS: We included patients who received temozolomide concurrent with and adjuvant to radiotherapy after diagnosis of GBM and had a second surgery performed at least 3 months after radiotherapy completion...
March 8, 2017: Oncologist
https://www.readbyqxmd.com/read/28273245/grape-juice-increases-the-bdnf-levels-but-not-alter-the-s100b-levels-in-hippocampus-and-frontal-cortex-from-male-wistar-rats
#20
Caroline Dani, Ana Cristina Andreazza, Carlos Alberto Gonçalves, Flávio Kapizinski, João A P Henriques, Mirian Salvador
Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups...
March 2, 2017: Anais da Academia Brasileira de Ciências
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