Marianne Mazevet, Anissa Belhadef, Maxance Ribeiro, Delphine Dayde, Anna Llach, Marion Laudette, Tiphaine Belleville, Philippe Mateo, Mélanie Gressette, Florence Lefebvre, Ju Chen, Christilla Bachelot-Loza, Catherine Rucker-Martin, Frank Lezoualch, Bertrand Crozatier, Jean-Pierre Benitah, Marie-Catherine Vozenin, Rodolphe Fischmeister, Ana-Maria Gomez, Christophe Lemaire, Eric Morel
Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy and heart failure. This study sought to investigate the role of the Exchange Protein directly Activated by cAMP (EPAC) in Dox-induced cardiotoxicity and the potential cardioprotective effects of EPAC inhibition. We show that Dox induces DNA damage and cardiomyocyte cell death with apoptotic features...
August 8, 2023: ELife