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Drosophila mir-92

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https://www.readbyqxmd.com/read/26000445/downregulation-of-the-host-gene-jigr1-by-mir-92-is-essential-for-neuroblast-self-renewal-in-drosophila
#1
Yeliz Yuva-Aydemir, Xia-Lian Xu, Ozkan Aydemir, Eduardo Gascon, Serkan Sayin, Wenke Zhou, Yang Hong, Fen-Biao Gao
Intragenic microRNAs (miRNAs), located mostly in the introns of protein-coding genes, are often co-expressed with their host mRNAs. However, their functional interaction in development is largely unknown. Here we show that in Drosophila, miR-92a and miR-92b are embedded in the intron and 3'UTR of jigr1, respectively, and co-expressed with some jigr1 isoforms. miR-92a and miR-92b are highly expressed in neuroblasts of larval brain where Jigr1 expression is low. Genetic deletion of both miR-92a and miR-92b demonstrates an essential cell-autonomous role for these miRNAs in maintaining neuroblast self-renewal through inhibiting premature differentiation...
May 2015: PLoS Genetics
https://www.readbyqxmd.com/read/24795565/hox-gene-regulation-in-the-central-nervous-system-of-drosophila
#2
REVIEW
Maheshwar Gummalla, Sandrine Galetti, Robert K Maeda, François Karch
Hox genes specify the structures that form along the anteroposterior (AP) axis of bilateria. Within the genome, they often form clusters where, remarkably enough, their position within the clusters reflects the relative positions of the structures they specify along the AP axis. This correspondence between genomic organization and gene expression pattern has been conserved through evolution and provides a unique opportunity to study how chromosomal context affects gene regulation. In Drosophila, a general rule, often called "posterior dominance," states that Hox genes specifying more posterior structures repress the expression of more anterior Hox genes...
2014: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/23051640/functional-characterization-of-drosophila-micrornas-by-a-novel-in-vivo-library
#3
Claus Schertel, Tobias Rutishauser, Klaus Förstemann, Konrad Basler
Animal microRNAs (miRNA) are implicated in the control of nearly all cellular functions. Due to high sequence redundancy within the miRNA gene pool, loss of most of these 21- to 24-bp long RNAs individually does not cause a phenotype. Thus, only very few miRNAs have been associated with clear functional roles. We constructed a transgenic UAS-miRNA library in Drosophila melanogaster that contains 180 fly miRNAs. This library circumvents the redundancy issues by facilitating the controlled misexpression of individual miRNAs and is a useful tool to complement loss-of-function approaches...
December 2012: Genetics
https://www.readbyqxmd.com/read/20167119/identification-of-micrornas-expressed-in-two-mosquito-vectors-aedes-albopictus-and-culex-quinquefasciatus
#4
Rebecca L Skalsky, Dana L Vanlandingham, Frank Scholle, Stephen Higgs, Bryan R Cullen
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression in a variety of organisms, including insects, vertebrates, and plants. miRNAs play important roles in cell development and differentiation as well as in the cellular response to stress and infection. To date, there are limited reports of miRNA identification in mosquitoes, insects that act as essential vectors for the transmission of many human pathogens, including flaviviruses...
February 18, 2010: BMC Genomics
https://www.readbyqxmd.com/read/17613543/mirnas-in-cancer-approaches-aetiology-diagnostics-and-therapy
#5
REVIEW
Cherie Blenkiron, Eric A Miska
MicroRNAs (miRNAs) are causing tremendous excitement in cancer research. MiRNAs are a large class of short non-coding RNAs that are found in many plants, animals and DNA viruses and often act to inhibit gene expression post-transcriptionally. Approximately 500 miRNA genes have been identified in the human genome. Their function is largely unknown, but data from worms, flies, fish and mice suggest that they have important roles in animal growth, development, homeostasis and disease. MiRNA expression profiles demonstrate that many miRNAs are deregulated in human cancers...
April 15, 2007: Human Molecular Genetics
https://www.readbyqxmd.com/read/15136036/molecular-evolution-of-a-microrna-cluster
#6
Andrea Tanzer, Peter F Stadler
Many of the known microRNAs are encoded in polycistronic transcripts. Here, we reconstruct the evolutionary history of the mir17 microRNA clusters which consist of miR-17, miR-18, miR-19a, miR-19b, miR-20, miR-25, miR-92, miR-93, miR-106a, and miR-106b. The history of this cluster is governed by an initial phase of local (tandem) duplications, a series of duplications of entire clusters and subsequent loss of individual microRNAs from the resulting paralogous clusters. The complex history of the mir17 microRNA family appears to be closely linked to the early evolution of the vertebrate lineage...
May 28, 2004: Journal of Molecular Biology
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