keyword
https://read.qxmd.com/read/38546037/hesperetin-blocks-poxvirus-replication-with-a-low-tendency-to-select-for-drug-resistant-viral-variants
#1
JOURNAL ARTICLE
Assim Verma, Ramesh Kumar Dedar, Ram Kumar, Yogesh Chander, Himanshu Kamboj, Garvit Kumar, Rekha Verma, Santosh Kumari, Shalini Sharma, Bhupendra N Tripathi, Sanjay Barua, Naveen Kumar
In this study, we demonstrated the antiviral efficacy of hesperetin against multiple poxviruses, including buffalopox virus (BPXV), vaccinia virus (VACV), and lumpy skin disease virus (LSDV). The time-of-addition and virus step-specific assays indicated that hesperetin reduces the levels of viral DNA, mRNA, and proteins in the target cells. Further, by immunoprecipitation (IP) of the viral RNA from BPXV-infected Vero cells and a cell-free RNA-IP assay, we demonstrated that hesperetin-induced reduction in BPXV protein synthesis is also consistent with diminished interaction between eukaryotic translation initiation factor eIF4E and the 5' cap of viral mRNA...
April 2024: Journal of Medical Virology
https://read.qxmd.com/read/38545601/multireceptor-phage-cocktail-against-salmonella-enterica-to-circumvent-phage-resistance
#2
JOURNAL ARTICLE
Carlos E Martinez-Soto, Michael McClelland, Andrew M Kropinski, Janet T Lin, Cezar M Khursigara, Hany Anany
Non-Typhoidal Salmonella (NTS) is one of the most common food-borne pathogens worldwide, with poultry products being the major vehicle for pathogenesis in humans. The use of bacteriophage (phage) cocktails has recently emerged as a novel approach to enhancing food safety. Here, a multireceptor Salmonella phage cocktail of five phages was developed and characterized. The cocktail targets four receptors: O-antigen, BtuB, OmpC, and rough Salmonella strains. Structural analysis indicated that all five phages belong to unique families or subfamilies...
2024: Microlife
https://read.qxmd.com/read/38545561/electrical-impedance-tomography-in-anaesthetised-chickens-gallus-domesticus
#3
JOURNAL ARTICLE
Adrian M Wong, Hei Y Lum, Gabrielle C Musk, Timothy H Hyndman, Andreas D Waldmann, Deborah J Monks, Ross S Bowden, Martina Mosing
The applicability of electrical impedance tomography (EIT) in birds is unknown. This study aimed to evaluate the use of EIT in anaesthetised chickens in four recumbency positions. Four adult Hyline chickens were anaesthetised with isoflurane in oxygen, and intubated endotracheally for computed tomography (CT). A rubber belt was placed around the coelom caudal to the shoulder joint. A chicken-specific finite element (FE) model, which is essential to generate anatomically accurate functional EIT images for analysis, was constructed based on the CT images obtained at the belt level...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38545294/a-new-neodymium-complex-on-renewable-magnetic-biochar-nanoparticles-as-an-environmentally-friendly-recyclable-and-efficient-nanocatalyst-in-the-homoselective-synthesis-of-tetrazoles
#4
JOURNAL ARTICLE
Bahman Tahmasbi, Parisa Moradi, Mitra Darabi
Inexpensive, stable, selective, and recyclable nanocatalysts, waste regeneration, and utilization of safe and available solvents are of interest and important factors in laboratory science and industrial applications of green chemistry. Therefore, herein, biochar nanoparticles (BNPs) were synthesized through chicken manure pyrolysis as a novel method for waste recycling. Then, in order to improve their recyclability, the obtained BNPs were magnetized using magnetic nickel nanoparticles. Then, the surface of the biochar magnetic nanoparticles (BMNPs) was modified by (3-chloropropyl)trimethoxysilane (3-CPTMS) and further a novel neodymium Schiff-base complex was immobilized on the surface of the modified BMNPs, denoted as Nd-Schiff-base@BMNPs...
March 26, 2024: Nanoscale advances
https://read.qxmd.com/read/38545210/the-origin-of-genetic-diversity-of-indigenous-cockfighting-chickens-of-pakistan-by-analyzing-the-mtdna
#5
JOURNAL ARTICLE
Sajid Mahmood, Mian Sayed Khan, Zaib Ullah, Raman Akinyanju Lawal, Olivier Hanotte
In Pakistan, the origin of the indigenous cockfighting chicken (ICC) or gamecock population is unknown. However, it is speculated that this might have been associated with domestication, an event linked to recreational, entertainment (cockfighting), religious or ornamental activities. This study aims to understand the origin and genetic diversity of the ICC population in Pakistan. A total of 185 ICC population and 10 captive Indian red junglefowl ( Gallus gallus murghi ) were analyzed for genetic diversity indices and phylogenetic reconstruction using a 397 bp of mtDNA D-loop region...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38544751/effect-of-different-salt-additions-on-the-taste-and-flavor-related-compounds-in-chicken-soup
#6
JOURNAL ARTICLE
Rong Jia, Xiaoyan Yin, Yucai Yang, Guozhou Liao, Dahai Gu, Yuehong Pu, Guiying Wang
Chicken soup is popular among consumers because of its delicious taste, strong flavor, and abundant nutritional value. Twenty-four Yunnan local hens were stewed by adding different amounts of NaCl [1.5, 2, 2.5, 3%, m/m, calculated based on chicken carcass weight; chicken: water = 1:2 (m/m)] to study the effect of salt addition on taste- and flavor-related compounds in chicken soup. Sensory evaluation results showed that the 2 and 2.5% NaCl treatment groups had higher scores. Water-soluble small molecule compounds were detected by LC-Q/TOF-MS based metabolomics approach, among which amino acids and their derivatives, nucleic acids, and small peptides were the main components...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38544332/implementation-of-a-national-monitoring-programme-of-campylobacter-in-irish-broilers-to-measure-progress-of-on-farm-and-primary-processing-control-measures
#7
JOURNAL ARTICLE
Olwen Golden, Montserrat Gutierrez, Joseph O'Flaherty, Kilian Unger, Bernadette Doyle, Tara Keogh, Joanne McLernon, Rachel Pearce, Tony O'Brien, William Byrne
BACKGROUND: Campylobacter is the most common food-borne pathogen in the European Union. In 2018, the crude incidence rate in Ireland was 63.6 per 100,000 population. Chicken is considered an important source of infection for humans. In 2015, the Campylobacter Stakeholders' Group (CSG) was established to reduce Campylobacter contamination levels in Irish broiler flocks. AIMS: This work aimed to describe the Campylobacter monitoring programme that was established by the CSG, to analyse the results of this testing between 2019 and 2022, and to assess progress...
March 27, 2024: Zoonoses and Public Health
https://read.qxmd.com/read/38543921/reduction-in-interferon-stimulated-genes-contributes-to-high-yield-production-of-influenza-virus-in-suspension-mdck-cells
#8
JOURNAL ARTICLE
Qi Wang, Jian Luo, Beibei Li, Qian Ye, Wenting Xu, Feixia Gao, Linting Zhou, Wenyue Lu, Wen-Song Tan, Xiuling Li
Compared with the traditional vaccine produced in embryonated chicken eggs, cell-based manufacturing represented by the Madin-Darby canine kidney (MDCK) cell line has a larger production scale and reduces the risk of egg shortage in a pandemic. Establishing a culture system that enables high production of the influenza virus is a key issue in influenza vaccine production. Here, a serum-free suspension culture of MDCK (sMDCK) cells was obtained from adherent MDCK (aMDCK) cells by direct adaptation. Viral infection experiments showed that viral yields of influenza A/B virus in sMDCK cells were higher than in aMDCK cells...
March 9, 2024: Vaccines
https://read.qxmd.com/read/38543897/the-development-of-a-novel-fiber-2-subunit-vaccine-against-fowl-adenovirus-serotype-4-formulated-with-oil-adjuvants
#9
JOURNAL ARTICLE
Wenjian Liu, Meng Liu, Shuaiwen Wang, Zhihui Tang, Jiwen Liu, Suquan Song, Liping Yan
Hepatitis-hydropericardium syndrome (HHS), caused by fowl adenovirus serotype 4 (FAdV-4), has been widely spread across China, resulting in great financial losses in the poultry industry. Therefore, efficient vaccines against this disease urgently need to be developed. In our study, the fiber-2 and penton base proteins derived from the FAdV-4 JS strain were expressed in a prokaryotic system ( E. coli ) in a soluble form. Then, the efficacy of the two recombinant proteins formulated with cheap and widely used adjuvants (Marcol™ 52 white oil) were respectively tested, and the minimum immune doses and safety of the above proteins were also determined...
March 1, 2024: Vaccines
https://read.qxmd.com/read/38543860/development-of-a-highly-efficient-crispr-cas9-mediated-herpesvirus-of-turkey-based-vaccine-against-novel-variant-infectious-bursal-disease-virus
#10
JOURNAL ARTICLE
Jun-Feng Zhang, Jong-Yeol Park, Sang-Won Kim, Yu-Ri Choi, Se-Yeoun Cha, Hyung-Kwan Jang, Bai Wei, Min Kang
Infectious bursal disease (IBD), caused by IBD virus (IBDV), is an extremely contagious immunosuppressive disease that causes major losses for the poultry industry worldwide. Recently, the novel variant IBDV (G2d) has been highly prevalent in Korea, but the current vaccines against this very virulent IBDV have limited efficacy against this novel variant. To develop a vaccine against this variant IBDV, a recombinant virus designated rHVT-VP2 was constructed by inserting the IBDV (G2d) VP2 gene into herpesvirus of turkeys (HVT) using CRISPR/Cas9 gene-editing technology...
February 23, 2024: Vaccines
https://read.qxmd.com/read/38543696/analysis-of-chicken-ifitm3-gene-expression-and-its-effect-on-avian-reovirus-replication
#11
JOURNAL ARTICLE
Hongyu Ren, Sheng Wang, Zhixun Xie, Lijun Wan, Liji Xie, Sisi Luo, Meng Li, Zhiqin Xie, Qing Fan, Tingting Zeng, Yanfang Zhang, Minxiu Zhang, Jiaoling Huang, You Wei
Interferon-inducible transmembrane protein 3 (IFITM3) is an antiviral factor that plays an important role in the host innate immune response against viruses. Previous studies have shown that IFITM3 is upregulated in various tissues and organs after avian reovirus (ARV) infection, which suggests that IFITM3 may be involved in the antiviral response after ARV infection. In this study, the chicken IFITM3 gene was cloned and analyzed bioinformatically. Then, the role of chicken IFITM3 in ARV infection was further explored...
February 21, 2024: Viruses
https://read.qxmd.com/read/38543692/differential-impact-of-massachusetts-canadian-4-91-and-california-cal-1737-genotypes-of-infectious-bronchitis-virus-infection-on-lymphoid-organs-of-chickens
#12
JOURNAL ARTICLE
Reham M Abd-Elsalam, Shahnas M Najimudeen, Motamed E Mahmoud, Mohamed S H Hassan, Rodrigo A Gallardo, Mohamed Faizal Abdul-Careem
Infectious bronchitis virus (IBV) induces severe economic losses in chicken farms due to the emergence of new variants leading to vaccine breaks. The studied IBV strains belong to Massachusetts (Mass), Canadian 4/91, and California (Cal) 1737 genotypes that are prevalent globally. This study was designed to compare the impact of these three IBV genotypes on primary and secondary lymphoid organs. For this purpose, one-week-old specific pathogen-free chickens were inoculated with Mass, Canadian 4/91, or Cal 1737 IBV variants, keeping a mock-infected control...
February 21, 2024: Viruses
https://read.qxmd.com/read/38543652/effects-of-six-natural-compounds-and-their-derivatives-on-the-control-of-coccidiosis-in-chickens
#13
JOURNAL ARTICLE
Yue Hou, Bo Han, Zehua Lin, Qizheng Liu, Zhenhe Liu, Hongbin Si, Dandan Hu
Chicken coccidiosis costs the poultry industry over GBP 10 billion per year. The main method of preventing and controlling coccidiosis in chickens continues to be the use of drugs. Unfortunately, the prevalence of drug resistance in the field reduces or even eliminates the effectiveness of drugs, and drug residues in the food supply chain can also can be harmful to humans. Therefore, safe and effective anticoccidial drugs are urgently needed. Natural products have many advantages such as being safe, effective and inexpensive and are a sustainable way to control coccidiosis...
March 17, 2024: Microorganisms
https://read.qxmd.com/read/38543570/a-one-pot-convenient-rpa-crispr-based-assay-for-salmonella-enterica-serovar-indiana-detection
#14
JOURNAL ARTICLE
Jiansen Gong, Di Zhang, Lixia Fu, Yongyi Dong, Kun Wu, Xinhong Dou, Chengming Wang
Salmonella enterica serovar Indiana ( S. Indiana) is among the most prevalent serovars of Salmonella and is closely associated with foodborne diseases worldwide. In this study, we combined a recombinase polymerase amplification (RPA) technique with clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated (Cas) protein Cas12b (CRISPR/Cas12b)-based biosensing in a one-pot platform to develop a novel one-step identification method for S. Indiana infection diagnosis. The entire RPA-CRISPR/Cas12b reaction can be completed at 41 °C within 1 h without the need for specific instruments...
March 5, 2024: Microorganisms
https://read.qxmd.com/read/38543522/the-impact-of-early-life-cecal-microbiota-transplantation-on-social-stress-and-injurious-behaviors-in-egg-laying-chickens
#15
REVIEW
Yuechi Fu, Jiaying Hu, Huanmin Zhang, Marisa A Erasmus, Timothy A Johnson, Heng-Wei Cheng
Injurious behaviors (i.e., aggressive pecking, feather pecking, and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress and related health and welfare issues as well as economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation and related neuropsychiatric disorders via the microbiota-gut-brain axis, and consequently increasing the frequency and intensity of aggression and violent behaviors...
February 26, 2024: Microorganisms
https://read.qxmd.com/read/38542940/liquid-chromatography-with-tandem-mass-spectrometry-analysis-of-carboxymethyl-lysine-in-indonesian-foods
#16
JOURNAL ARTICLE
Patricia Budihartanti Liman, Mulyana, Yenny, Ratna Djuwita
There is little data on directly measured carboxymethyl lysine (CML) content in Indonesian foods. This study aimed to generate a database of CML values in foods commonly consumed in West Java and West Sumatra. The results were to be used to update our previous estimated CML values. CML values in food samples were measured using high-pressure liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). Food protein content was analyzed by Kjeldahl's method or inferred from the nutrition facts' label. A total of 210 food samples were examined, with the food groups of meat and poultry (1...
March 15, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542488/transcriptome-and-metabolome-profiling-provide-new-insights-into-disuse-muscle-atrophy-in-chicken-the-potential-role-of-fast-twitch-muscle-fibers
#17
JOURNAL ARTICLE
Zipei Yao, Lijin Guo, Li Zhang, Qinghua Nie
Disuse muscle atrophy is a disease caused by restricted activity, affecting human health and animal protein quality. While extensive research on its mechanism has been studied in mammals, comparatively little is known about this process in chickens, which are a significant source of protein for human consumption worldwide. Understanding the mechanisms underlying skeletal muscle atrophy in chickens is crucial for improving poultry health and productivity, as well as for developing strategies to mitigate muscle loss...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541959/association-between-left-atrial-appendage-morphology-and-clot-histology-in-patients-with-embolic-ischemic-stroke-an-exploratory-study
#18
JOURNAL ARTICLE
Givi Lengvenis, Julius Drachneris, Edvardas Žurauskas, Aleksandra Ekkert, Andrius Berūkštis, Marius Kurminas, Rokas Girčius, Kipras Mikelis, Andrej Afanasjev, Kristina Ryliškienė, Arvydas Laurinavičius, Algirdas Edvardas Tamošiūnas
BACKGROUND: Acute embolic ischemic stroke poses a significant healthcare challenge. Histological clot features' variability among patients with acute ischemic stroke treated by mechanical thrombectomy has potential implications for determining treatment and etiology. This study investigated the clot histological feature differences among patients who experienced cardioembolic stroke and embolic stroke of undetermined source with different left atrial appendage (LAA) morphologies. METHODS: We conducted a prospective observational study involving 79 patients with acute embolic ischemic stroke undergoing mechanical thrombectomy...
March 17, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38540959/identification-of-characteristic-bioactive-compounds-in-silkie-chickens-their-effects-on-meat-quality-and-their-gene-regulatory-network
#19
JOURNAL ARTICLE
Xinting Yang, Chaohua Tang, Bowen Ma, Qingyu Zhao, Yaxiong Jia, Qingshi Meng, Yuchang Qin, Junmin Zhang
Silkie chicken, an important chicken breed with high medicinal and nutritional value, has a long history of being used as a dietary supplement in China. However, the compounds with health-promoting effects in Silkie chickens remain unclear. In the present study, we conducted a comprehensive analysis of metabolic and lipidomic profiles to identify the characteristic bioactive compounds in Silkie chickens, using a common chicken breed as control. The results showed that the levels of 13 metabolites including estradiol, four lipid subclasses including cardiolipin (CL), eight lipid molecules, and three fatty acids including docosahexaenoic acid (C22:6) were significantly increased in Silkie chickens, which have physiological activities such as resisting chronic diseases and improving cognition...
March 21, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38540955/disclosing-the-functional-potency-of-three-oxygenated-monoterpenes-in-combating-microbial-pathogenesis-from-targeting-virulence-factors-to-chicken-meat-preservation
#20
JOURNAL ARTICLE
Sarra Akermi, Moufida Chaari, Khaoula Elhadef, Mariam Fourati, Ahlem Chakchouk Mtibaa, Sofia Agriopoulou, Slim Smaoui, Lotfi Mellouli
During the last few decades, there has existed an increased interest in and considerable consumer preference towards using natural and safe compounds derived from medicinal plants as alternatives to synthetic preservatives to combat microbial pathogenicity. In this regard, the present study investigated the possible synergistic interactions of the anti-foodborne bacterial capacity of linalool (L), eucalyptol (E), and camphor (C). The antibacterial synergistic effect was determined against Staphylococcus aureus , Listeria monocytogenes , Salmonella enterica Typhimurium, and Escherichia coli ...
March 21, 2024: Foods (Basel, Switzerland)
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