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https://www.readbyqxmd.com/read/29775737/deltex-interacts-with-eiger-and-consequently-influences-the-cell-death-in-drosophila-melanogaster
#1
Debdeep Dutta, Ankita Singh, Maimuna Sali Paul, Vartika Sharma, Mousumi Mutsuddi, Ashim Mukherjee
TNF-JNK signaling is one of the highly conserved signaling pathways that regulate a broad spectrum of cellular processes including proliferation and apoptosis. Eiger, the sole homologue of TNF in Drosophila, initiates the TNF-JNK pathway to induce cell death. Previously, Deltex (Dx) has been identified as a Notch signaling component that regulates vesicular trafficking of Notch. In the present study, we have investigated the interaction between these two proteins in order to identify how Dx influences the activity of Eiger...
May 15, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29772558/the-function-of-replication-and-scf-complex-during-drosophila-wing-development
#2
Hidetsugu Kohzaki
Chromosomal DNA replication machinery functions in the growing cells and organs in multicellular organisms. We previously demonstrated that its knockdown in several tissues of Drosophila led to a rough eye phenotype, the loss of bristles in the eye and female sterile. In this paper, I investigated in detail the wing phenotype using RNAi flies, and observed that the knockdown not only of Mcm10 but also of some other prereplicative complex components including Cdt1, Polα-primase, RPA, Psf2 (partner of SLD five 2; a subunit of GINS (Go, Ichi, Nii, and San; five, one, two, and three in Japanese) and Rfc3 (replication factor C 3; a subunit of RFC complex) demonstrated wing phenotypes, using Gal4-driver flies...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29764901/the-histone-demethylase-kdm5-is-essential-for-larval-growth-in-drosophila
#3
Coralie Drelon, Helen M Belalcazar, Julie Secombe
Regulated gene expression is necessary for developmental and homeostatic processes. The KDM5 family of transcriptional regulators are histone H3 lysine 4 demethylases that can function through both demethylase-dependent and independent mechanisms. While loss and overexpression of KDM5 proteins are linked to intellectual disability and cancer, respectively, their normal developmental functions remain less characterized. Drosophila melanogaster provides an ideal system to investigate KDM5 function, as it encodes a single ortholog in contrast to the four paralogs found in mammalian cells...
May 15, 2018: Genetics
https://www.readbyqxmd.com/read/29753017/size-matters-aurora-a-controls-drosophila-larval-development
#4
Lucie Vaufrey, Christine Balducci, René Lafont, Claude Prigent, Stéphanie Le Bras
In metazoans, organisms arising from a fertilized egg, the embryo will develop through multiple series of cell divisions, both symmetric and asymmetric, leading to differentiation. Aurora A is a serine threonine kinase highly involved in such divisions. While intensively studied at the cell biology level, its function in the development of a whole organism has been neglected. Here we investigated the pleiotropic effect of Aurora A loss-of-function in Drosophila larval early development. We report that Aurora A is required for proper larval development timing control through direct and indirect means...
May 9, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29752350/the-domino-swi2-snf2-gene-product-represses-cell-death-in-drosophila-melanogaster
#5
Kaitlyn Ellis, Joanna Wardwell-Ozgo, Kenneth H Moberg, Barry Yedvobnick
The Drosophila domino locus encodes DNA-dependent ATPases of the SWI2/SNF2 class. This class of chromatin remodeler is associated with an array of cellular activities encompassing transcription, replication, repair and recombination. Moreover, domino was observed initially to maintain a repressive chromatin state via genetic interaction studies with homeotic genes. Although domino mutations were also characterized with a cell death phenotype, its association with a death pathway has not been investigated. Here we have used targeted RNA interference to depress domino function in the wing...
May 11, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29749926/metagenomic-analysis-of-varroa-free-australian-honey-bees-apis-mellifera-shows-a-diverse-picornavirales-virome
#6
John M K Roberts, Denis L Anderson, Peter A Durr
The viral landscape of the honey bee (Apismellifera) has changed as a consequence of the global spread of the parasitic mite Varroa destructor and accompanying virulent strains of the iflavirus deformed wing virus (DWV), which the mite vectors. The presence of DWV in honey bee populations is known to influence the occurrence of other viruses, suggesting that the current known virome of A. mellifera may be undercharacterized. Here we tested this hypothesis by examining the honey bee virome in Australia, which is uniquely free of parasitic mites or DWV...
May 11, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29748763/genome-wide-association-analysis-of-host-genotype-and-plastic-wing-morphological-variation-of-an-endoparasitoid-wasp-asobara-japonica-hymenoptera-braconidae
#7
Shinpei Yamashita, Tomohiro Takigahira, Kazuo H Takahashi
Accumulating evidence suggests that genotype of host insects influences the development of koinobiont endoparasitoids. Although there are many potential genetic variations that lead to the internal body environmental variations of host insects, association between the host genotype and the parasitoid development has not been examined in a genome-wide manner. In the present study, we used highly inbred whole genome sequenced strains of Drosophila melanogaster to associate single nucleotide polymorphisms (SNPs) of host flies with morphological traits of Asobara japonica, a larval-pupal parasitoid wasp that infected those hosts...
May 10, 2018: Genetica
https://www.readbyqxmd.com/read/29739818/spermiogenesis-and-male-fertility-require-the-function-of-suppressor-of-hairy-wing-in-somatic-cyst-cells-of-drosophila
#8
Tingting Duan, Pamela K Geyer
Drosophila Suppressor of Hairy-wing [Su(Hw)] protein is an example of a multivalent transcription factor. Although best known for its role in establishing the chromatin insulator of the gypsy retrotransposon, Su(Hw) functions as an activator and repressor at non- gypsy genomic sites. It remains unclear how the different regulatory activities of Su(Hw) are utilized during development. Motivated from observations of spatially restricted expression of Su(Hw) in the testis, we investigated the role of Su(Hw) in spermatogenesis to advance an understanding of its developmental contributions as an insulator, repressor and activator protein...
May 8, 2018: Genetics
https://www.readbyqxmd.com/read/29735293/anchor-negatively-regulates-bmp-signalling-to-control-drosophila-wing-development
#9
Xiao Chun Wang, Ziguang Liu, Li Hua Jin
G protein-coupled receptors play particularly important roles in many organisms. The novel Drosophila gene anchor is an orthologue of vertebrate GPR155. However, the roles of anchor in molecular functions and biological processes, especially in wing development, remain unknown. Knockdown of anchor resulted in an increased wing size and additional and thickened veins. These abnormal wing phenotypes were similar to those observed in BMP signalling gain-of-function experiments. We observed that the BMP signalling indicator p-Mad was significantly increased in wing discs in which anchor RNAi was induced in larvae and accumulated abnormally in intervein regions in pupae...
April 25, 2018: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29695495/multiple-arginine-residues-are-methylated-in-drosophila-mre11-and-required-for-survival-following-ionizing-radiation
#10
Qing Yuan, Ran Tian, Haiying Zhao, Lijuan Li, Xiaolin Bi
Mre11 is a key player for DNA double strand break repair. Previous studies have shown that mammalian Mre11 is methylated at multiple arginines in its C-terminal Glycine-Arginine-Rich motif (GAR) by protein arginine methyltransferase PRMT1. Here, we found that the Drosophila Mre11 is methylated at arginines 559, 563, 565, and 569 in the GAR motif by DART1, the Drosophila homolog of PRMT1. Mre11 interacts with DART1 in S2 cells, and this interaction does not require the GAR motif. Arginines methylated Mre11 localizes exclusively in the nucleus as soluble nuclear protein or chromatin-binding protein...
April 25, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29692083/-the-role-of-white-gene-and-its-mechanism-during-the-formation-of-curly-wing-in-drosophila-melanogaster
#11
Cheng Li Wu, Xin da Lin, Yan Yun Jiang, Shuai Shuai Meng
Curly wing is one of the most frequently used genetic markers in Drosophila melanogaster, but its molecular mechanism is remained unclear. Previous results have showed that physicochemical stimulation would affect the formation of the cruly wing. Our recent study found that H2 O2 could not only affect the eclosion rate of D. melanogaster, but also induce the formation of curly wing. Here, we aimed to uncover the specific factors influencing the formation of curly wing in D. melanogaster via changing the concentration of H2 O2 and the temperature as well as the time of H2 O2 treatment...
February 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29668869/multistate-comparison-of-attractants-and-the-impact-of-fruit-development-stage-on-trapping-drosophila-suzukii-diptera-drosophilidae-in-raspberry-and-blueberry
#12
Benjamin D Jaffe, Alina Avanesyan, Harit K Bal, Yan Feng, Joshua Grant, Matthew J Grieshop, Jana C Lee, Oscar E Liburd, Elena Rhodes, Cesar Rodriguez-Saona, Ashfaq A Sial, Aijun Zhang, Christelle Guédot
Spotted-wing drosophila, Drosophila suzukii Matsumura (Diptera: Drosophilidae), is an invasive pest of soft-skinned fruits across the globe. Effective monitoring is necessary to manage this pest, but suitable attractants are still being identified. In this study, we combined lures with fermenting liquid baits to improve D. suzukii trapping specificity and attractiveness. We also measured the efficiency and specificity of baits/lures during different times of the season; the reproductive status of females among baits/lures; and the effects of locations and crop type on these response variables...
April 14, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29660312/the-egf-ras-pathway-controls-growth-in-drosophila-via-ribosomal-rna-synthesis
#13
Shrivani Sriskanthadevan-Pirahas, Joshua Lee, Savraj S Grewal
The Ras small G-protein is a conserved regulator of cell and tissue growth during animal development. Studies in Drosophila have shown how Ras can stimulate a Raf-MEK-ERK signaling pathway to control cell growth and proliferation in response to epidermal growth factor (EGF) stimulation. This work has also defined several transcription factors that can function as downstream growth effectors of EGF/Ras/ERK pathway by stimulating mRNA transcription. Here we report on stimulation of RNA polymerase I (Pol I)-mediated ribosomal RNA (rRNA) synthesis as a growth effector of Ras/ERK signalling in Drosophila...
April 13, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29656148/basement-membrane-mechanics-shape-development-lesson-from-the-fly
#14
REVIEW
William Ramos-Lewis, Andrea Page-McCaw
Basement membrane plays a foundational role in the structure and maintenance of many tissues throughout the animal kingdom. In addition to signaling to cells through cell-surface receptors, basement membrane directly influences the development and maintenance of organ shape via its mechanical properties. The mechanical properties of basement membrane are dictated by its composition, geometry, and crosslinking. Distinguishing between the ways the basement membrane influences morphology in vivo poses a major challenge...
April 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29649492/a-cytoskeletal-activator-and-inhibitor-are-downstream-targets-of-the-frizzled-starry-night-planar-cell-polarity-pathway-in-the-drosophila-epidermis
#15
REVIEW
Paul N Adler
The frizzled pathway regulates the planar polarity of epithelial cells. In insects this is manifested by the polarity of cuticular structures such as hairs (trichomes) and sensory bristles. A variety of evidence has established that this is achieved by regulating the subcellular location for activating the cytoskeleton in the epithelial cells. How this is accomplished is still poorly understood. In the best-studied tissue, the Drosophila pupal wing two important cytoskeletal regulators have been identified...
April 9, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29618026/nitric-oxide-fumigation-for-control-of-spotted-wing-drosophila-diptera-drosophilidae-in-strawberries
#16
Xiangbing Yang, Yong-Biao Liu
Nitric oxide (NO) fumigation was conducted to determine the efficacy of controlling spotted wing drosophila (SWD), Drosophila suzukii Matsumura (Diptera: Drosophilidae), in strawberries and the effects on postharvest quality of strawberries under ultralow oxygen conditions at 2°C. Eight-hour fumigations with 1.0 and 3.0% NO were tested against different life stages of the insect to determine an effective treatment, and a 16-h fumigation was tested to determine the impact on strawberry quality. Complete control of eggs and larvae in strawberries was achieved in an 8-h fumigation with 3...
April 3, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29606421/a-camp-pka-kinesin-1-axis-promotes-the-axonal-transport-of-mitochondria-in-aging-drosophila-neurons
#17
Alessio Vagnoni, Simon L Bullock
Mitochondria play fundamental roles within cells, including energy provision, calcium homeostasis, and the regulation of apoptosis. The transport of mitochondria by microtubule-based motors is critical for neuronal structure and function. This process allows local requirements for mitochondrial functions to be met and also facilitates recycling of these organelles [1, 2]. An age-related reduction in mitochondrial transport has been observed in neurons of mammalian and non-mammalian organisms [3-6], and has been proposed to contribute to the broader decline in neuronal function that occurs during aging [3, 5-7]...
March 20, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29596913/wing-vein-development-in-the-sawfly-athalia-rosae-is-regulated-by-spatial-transcription-of-dpp-bmp-signaling-components
#18
Yunxian Huang, Masatsugu Hatakeyama, Osamu Shimmi
Wing venation among insects serves as an excellent model to address how diversified patterns are produced. Previous studies suggest that evolutionarily conserved Decapentaplegic (Dpp)/Bone Morphogenetic Protein (BMP) signal plays a critical role in wing vein development in the Dipteran Drosophila melanogaster and the Hymenopteran sawfly Athalia rosae. In sawfly, dpp is ubiquitously expressed in the wing during prepupal stages, but Dpp/BMP signal is localized in the future vein cells. Since localized BMP signaling involves BMP binding protein Crossveinless (Cv), redistribution of BMP ligands appears to be crucial for sawfly wing vein formation...
March 26, 2018: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29593084/flying-drosophila-maintain-arbitrary-but-stable-headings-relative-to-the-angle-of-polarized-light
#19
Timothy L Warren, Peter T Weir, Michael H Dickinson
Animals must use external cues to maintain a straight course over long distances. In this study, we investigated how the fruit fly, Drosophila melanogaster , selects and maintains a flight heading relative to the axis of linearly polarized light, a visual cue produced by the atmospheric scattering of sunlight. To track flies' headings over extended periods, we used a flight simulator that coupled the angular velocity of dorsally presented polarized light to the stroke amplitude difference of the animal's wings...
March 28, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29588363/effects-of-hypo-o-glcnacylation-on-drosophila-development
#20
Daniel N Mariappa, Andrew Ferenbach, Daan M F van Aalten
Post-translational modification of serine/threonine residues in nucleocytoplasmic proteins with N-acetylglucosamine (O -GlcNAcylation) is an essential regulatory mechanism in many cellular processes. In Drosophila , null mutants of the polycomb gene O-GlcNAc transferase (OGT, also known as super sex combs [ sxc ]) display homeotic phenotypes. To dissect the requirement for O -GlcNAc signaling in Drosophila development, we used CRISPR/Cas9 gene editing to generate rationally designed sxc catalytically hypomorphic or null point mutants...
March 27, 2018: Journal of Biological Chemistry
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