N S Younis, E S AlMasoud, F Al Khawajah, F J Alghazal, H M AlMofarfesh, L H Al-Khalaf, M S Al Otaibi, S M Alkhamis, Z A Al Naser, Z H Al Mousa, Z I Alabdulaziz, M E Mohamed
Colorectal cancer (CRC) is one of the leading causes of cancer deaths globally. We implemented a comprehensive literature review regarding CRC genetics studies to offer a perception into the genes associated with CRC recognized in Saudi patients. Definite genetic variants in ABCB1, ADIPOQ, CTNNB1, SFRP3, LRP6, CYP19A1, PARP-1, TDG genes exhibited significant protection against CRC development in Saudi population. Whereas, other gene mutations in ABCB1, ABCC1, CASR, IL-17F, NOTCH1, NOTCH4, PRNCR1, TDG, TLR2, TLR4, TLR-9, TSLP, TSLPR and TNF-α genes showed irrelevant correlation with CRC risk in Saudi Arabia...
May 2022: European Review for Medical and Pharmacological Sciences