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https://www.readbyqxmd.com/read/29667502/toxicoproteomic-assessment-of-liver-responses-to-acute-pyrrolizidine-alkaloid-intoxication-in-rats
#1
Yan-Hong Li, William Chi-Shing Tai, Imran Khan, Cheng Lu, Yao Lu, Wing-Yan Wong, Wood-Yee Chan, Wen-Luan Wendy Hsiao, Ge Lin
A toxicoproteomic study was performed on liver of rats treated with retrorsine (RTS), a representative hepatotoxic pyrrolizidine alkaloid at a toxic dose (140 mg/kg) known to cause severe acute hepatotoxicity. By comparing current data with our previous findings in mild liver lesions of rats treated with a lower dose of RTS, seven proteins and three toxicity pathways of vascular endothelial cell death, which was further verified by observed sinusoidal endothelial cell losses, were found uniquely associated with retrorsine-induced hepatotoxicity...
April 3, 2018: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/29667373/heritability-estimates-from-genome-wide-relatedness-matrices-in-wild-populations-application-to-a-passerine-using-a-small-sample-size
#2
C Perrier, B Delahaie, A Charmantier
Genomic developments have empowered the investigation of heritability in wild populations directly from genome wide relatedness matrices (GRM). Such GRM based approaches can in particular be used to improve or substitute approaches based on social pedigree (PED-social). However, measuring heritability from GRM in the wild has not been widely applied yet, especially using small samples and in non-model species. Here, we estimated heritability for four quantitative traits (tarsus length, wing length, bill length and body mass), using PED-social, a pedigree corrected by genetic data (PED-corrected) and a GRM from a small sample (n = 494) of blue tits from natural populations in Corsica genotyped at nearly 50,000 filtered SNPs derived from RAD-seq...
April 17, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29666756/classical-lepidopteran-wing-scale-colouration-in-the-giant-butterfly-moth-paysandisia-archon
#3
Doekele G Stavenga, Hein L Leertouwer, Andrej Meglič, Kazimir Drašlar, Martin F Wehling, Primož Pirih, Gregor Belušič
The palm borer moth Paysandisia archon (Castniidae; giant butterfly-moths) has brown dorsal forewings and strikingly orange-coloured dorsal hindwings with white spots surrounded by black margins. Here, we have studied the structure and pigments of the wing scales in the various coloured wing areas, applying light and electron microscopy and (micro)spectrophotometry, and we analysed the spatial reflection properties with imaging scatterometry. The scales in the white spots are unpigmented, those in the black and brown wing areas contain various amounts of melanin, and the orange wing scales contain a blue-absorbing ommochrome pigment...
2018: PeerJ
https://www.readbyqxmd.com/read/29666581/sex-and-tissue-specific-expression-profiles-of-odorant-binding-protein-and-chemosensory-protein-genes-in-bradysia-odoriphaga-diptera-sciaridae
#4
Yunhe Zhao, Jinfeng Ding, Zhengqun Zhang, Feng Liu, Chenggang Zhou, Wei Mu
Bradysia odoriphaga is an agricultural pest insect affecting the production of Chinese chive and other liliaceous vegetables in China, and it is significantly attracted by sex pheromones and the volatiles derived from host plants. Despite verification of this chemosensory behavior, however, it is still unknown how B. odoriphaga recognizes these volatile compounds on the molecular level. Many of odorant binding proteins (OBPs) and chemosensory proteins (CSPs) play crucial roles in olfactory perception. Here, we identified 49 OBP and 5 CSP genes from the antennae and body transcriptomes of female and male adults of B...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29666436/alterations-in-the-health-of-hibernating-bats-under-pathogen-pressure
#5
Hana Bandouchova, Tomáš Bartonička, Hana Berkova, Jiri Brichta, Tomasz Kokurewicz, Veronika Kovacova, Petr Linhart, Vladimir Piacek, Jiri Pikula, Alexandra Zahradníková, Jan Zukal
In underground hibernacula temperate northern hemisphere bats are exposed to Pseudogymnoascus destructans, the fungal agent of white-nose syndrome. While pathological and epidemiological data suggest that Palearctic bats tolerate this infection, we lack knowledge about bat health under pathogen pressure. Here we report blood profiles, along with body mass index (BMI), infection intensity and hibernation temperature, in greater mouse-eared bats (Myotis myotis). We sampled three European hibernacula that differ in geomorphology and microclimatic conditions...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665705/topogram-based-tube-current-modulation-of-head-computed-tomography-for-optimizing-image-quality-while-protecting-the-eye-lens-with-shielding
#6
Ming-Fang Lin, Chia-Yuen Chen, Yuan-Hao Lee, Chia-Wei Li, Leo E Gerweck, Hao Wang, Wing P Chan
Background Multiple rounds of head computed tomography (CT) scans increase the risk of radiation-induced lens opacification. Purpose To investigate the effects of CT eye shielding and topogram-based tube current modulation (TCM) on the radiation dose received by the lens and the image quality of nasal and periorbital imaging. Material and Methods An anthropomorphic phantom was CT-scanned using either automatic tube current modulation or a fixed tube current. The lens radiation dose was estimated using cropped Gafchromic films irradiated with or without a shield over the orbit...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29665523/revealing-the-microbiota-of-marketed-edible-insects-through-pcr-dgge-metagenomic-sequencing-and-real-time-pcr
#7
Andrea Osimani, Vesna Milanović, Cristiana Garofalo, Federica Cardinali, Andrea Roncolini, Riccardo Sabbatini, Francesca De Filippis, Danilo Ercolini, Claudia Gabucci, Annalisa Petruzzelli, Franco Tonucci, Francesca Clementi, Lucia Aquilanti
The present study aimed to identify the microbiota present in six species of processed edible insects produced in Thailand and marketed worldwide via the internet, namely, giant water bugs (Belostoma lutarium), black ants (Polyrhachis), winged termites (alates, Termitoidae), rhino beetles (Hyboschema contractum), mole crickets (Gryllotalpidae), and silkworm pupae (Bombyx mori). For each species, two samples of boiled, dried and salted insects were purchased. The microbial DNA was extracted from the insect samples and subjected to polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE), high-throughput sequencing and qualitative real-time PCR assays...
April 11, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29665375/luteolin-escape-mutants-of-dengue-virus-map-to-prm-and-ns2b-and-reveal-viral-plasticity-during-maturation
#8
Minhua Peng, Crystall Marie Dawn Swarbrick, Kitti Wing-Ki Chan, Dahai Luo, Wei Zhang, Xiaoping Lai, Geng Li, Subhash G Vasudevan
We previously showed that luteolin, a well-known plant-derived component found in the "heat clearing" class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6 μM) of the host proprotein convertase furin, an endoprotease that is required for maturation of flaviviruses in the trans-Golgi compartment. Luteolin also weakly inhibited recombinant dengue virus NS2B/NS3 protease (Ki 140.36 μM) non-competitively. In order to further explore the mechanism of inhibition we isolated resistant mutants by continuous passaging of DENV2 in the presence of increasing concentrations of luteolin...
April 14, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29664741/primary-vaginal-gastric-type-adenocarcinoma-and-vaginal-adenosis-exhibiting-gastric-differentiation-report-of-a-series-with-detailed-immunohistochemical-analysis
#9
Richard Wing-Cheuk Wong, Michelle Moore, Karen L Talia, Raji Ganesan, W Glenn McCluggage
So-called gastric-type adenocarcinoma and related premalignant lesions have been characterized in the cervix, but similar lesions are not widely recognized in the vagina. We report a series of 11 vaginal glandular lesions exhibiting gastric differentiation, comprising 5 cases of adenocarcinoma and 6 of adenosis. All cases occurred in adults (aged 33 to 69) with no known history of diethylstilboestrol exposure. The vaginal adenocarcinomas exhibited morphologic features identical to gastric-type adenocarcinoma of the cervix, but 1 case additionally demonstrated basaloid and sarcomatoid components, which have not been previously reported in cervical gastric-type adenocarcinoma...
April 16, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29664604/sub-bandgap-turn-on-near-infrared-to-visible-up-conversion-device-enabled-by-organic-inorganic-hybrid-perovskite-photovoltaic-absorber
#10
Hyeonggeun Yu, Yuanhang Cheng, Menglin Li, Sai-Wing Tsang, Franky So
Direct integration of an infrared photodetector with an organic light-emitting diode (OLED) enables low cost, pixel-free infrared imaging. However, the operation voltage of the resulting infrared-to-visible up-conversion is large due to the series device architecture. Here, we report a low voltage near infrared (NIR)-to-visible up-conversion device using formamidinium lead iodide as a NIR absorber integrated with a phosphorescent OLED. Due to the efficient photocarrier injection from the hybrid perovskite layer to the OLED, we observed a sub-bandgap turn-on of the OLED under NIR illumination...
April 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29662832/hong-kong-consensus-statements-for-the-management-of-unresectable-hepatocellular-carcinoma
#11
Tom Tan-To Cheung, Philip Chong-Hei Kwok, Stephen Chan, Chin-Cheung Cheung, Ann-Shing Lee, Victor Lee, Hoi-Ching Cheng, Nam-Hung Chia, Charing C N Chong, Tak-Wing Lai, Ada L Y Law, Mai-Yee Luk, Chi Chung Tong, Thomas C C Yau
Background: Hepatocellular carcinoma (HCC) is highly prevalent in Hong Kong due to the high prevalence of chronic hepatitis B infection. Liver cancer is the fourth most common cancer and the third most common cause of cancer death. Due to the high case load, there is a high level of local expertise in treating HCC, and the full spectrum of treatment modalities is available. This document summarizes how these modalities should be used based on the latest evidence. Summary: In 2 meetings held in early 2017, a multidisciplinary group of Hong Kong clinicians, including liver surgeons, interventional radiologists, clinical oncologists, and medical oncologists, met to update local consensus statements for management of HCC...
March 2018: Liver Cancer
https://www.readbyqxmd.com/read/29662761/inflammation-and-age-associated-skeletal-muscle-deterioration-sarcopaenia
#12
REVIEW
Jinyu Wang, Kwok-Sui Leung, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Ageing is accompanied by chronic inflammatory responses due to elevated circulatory inflammatory cytokine production. Several inflammatory cytokines have been shown to be responsible for a decrease in muscle mass. However, little is known about the possible relationship between inflammation and sarcopaenia. This review aims to summarise the existing evidence about inflammation and sarcopaenia. Sarcopaenia is defined as an age-related decrease of muscle mass and/or muscle strength; it is caused by multiple factors, such as skeletal muscle atrophy, neuromuscular junction degeneration, hormone imbalance, cytokine imbalance, protein synthesis and proteolysis...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661212/numerical-modeling-of-mosquito-population-dynamics-of-aedes-aegypti
#13
William M S Yamashita, Shyam S Das, Grigori Chapiro
BACKGROUND: The global incidences of dengue virus have increased the interest in studying and understanding the mosquito population dynamics. It is predominantly spread by Aedes aegypti in the tropical and sub-tropical countries in the world. Understanding these dynamics is important for public health in countries where climatic and environmental conditions are favorable for the propagation of these diseases. For this reason, a new model has been proposed to investigate the population dynamics of mosquitoes in a city...
April 16, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29660312/the-egf-ras-pathway-controls-growth-in-drosophila-via-ribosomal-rna-synthesis
#14
Shrivani Sriskanthadevan-Pirahas, Joshua Lee, Savraj S Grewal
The Ras small G-protein is a conserved regulator of cell and tissue growth during animal development. Studies in Drosophila have shown how Ras can stimulate a Raf-MEK-ERK signaling pathway to control cell growth and proliferation in response to epidermal growth factor (EGF) stimulation. This work has also defined several transcription factors that can function as downstream growth effectors of EGF/Ras/ERK pathway by stimulating mRNA transcription. Here we report on stimulation of RNA polymerase I (Pol I)-mediated ribosomal RNA (rRNA) synthesis as a growth effector of Ras/ERK signalling in Drosophila...
April 13, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29659925/tobacco-smoking-associated-alterations-in-the-immune-microenvironment-of-squamous-cell-carcinomas
#15
Alexis Desrichard, Fengshen Kuo, Diego Chowell, Ken-Wing Lee, Nadeem Riaz, Richard J Wong, Timothy A Chan, Luc G T Morris
Background: Tobacco smoking creates DNA damage, inducing mutations and potentially altering the tumor immune microenvironment. These types of genetic and immune microenvironment alterations are critical factors known to affect tumor response to immunotherapy. Here we analyze the association between the mutational signature of tobacco smoking, tumor mutational load, and metrics of immune activity in squamous cell carcinomas arising in the head and neck and lung. Methods: Using RNA and DNA sequencing data from The Cancer Genome Atlas head and neck (HNSC; n = 287) and lung (LUSC; n = 130) squamous cell carcinoma data sets and two independent gene expression data sets (HNSC, n = 136; LUSC, n = 75), we examined associations between the mutational smoking signature, mutation count, immune cell infiltration, cytolytic activity, and interferon-γ signaling...
April 11, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29659832/average-sperm-count-remains-unchanged-despite-reduction-in-maternal-smoking-results-from-a-large-cross-sectional-study-with-annual-investigations-over-21-years
#16
L Priskorn, L Nordkap, A K Bang, M Krause, S A Holmboe, D L Egeberg Palme, S B Winge, N Mørup, E Carlsen, U N Joensen, M Blomberg Jensen, K M Main, A Juul, N E Skakkebaek, T K Jensen, N Jørgensen
STUDY QUESTION: How are temporal trends in lifestyle factors, including exposure to maternal smoking in utero, associated to semen quality in young men from the general population? SUMMARY ANSWER: Exposure to maternal smoking was associated with lower sperm counts but no overall increase in sperm counts was observed during the study period despite a decrease in this exposure. WHAT IS KNOWN ALREADY: Meta-analyses suggest a continuous decline in semen quality but few studies have investigated temporal trends in unselected populations recruited and analysed with the same protocol over a long period and none have studied simultaneous trends in lifestyle factors...
April 11, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659709/progress-in-single-access-information-systems-for-wheat-and-rice-crop-improvement
#17
Armin Scheben, Chon-Kit Kenneth Chan, Locedie Mansueto, Ramil Mauleon, Pierre Larmande, Nickolai Alexandrov, Rod A Wing, Kenneth L McNally, Hadi Quesneville, David Edwards
Improving productivity of the staple crops wheat and rice is essential to feed the growing global population, particularly in the context of a changing climate. However, current rates of yield gain are insufficient to support the predicted population growth. New approaches are required to accelerate the breeding process, and many of these are driven by the application of large-scale crop data. To leverage the substantial volumes and types of data that can be applied for precision breeding, the wheat and rice research communities are working towards the development of integrated systems to access and standardize the dispersed, heterogeneous available data...
April 5, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29659142/an-uneasy-alliance-a-nesting-association-between-aggressive-ants-and-equally-fierce-social-wasps
#18
Pablo Servigne, Jérôme Orivel, Frédéric Azémar, James Carpenter, Alain Dejean, Bruno Corbara
Although the Neotropical territorially dominant arboreal ant Azteca chartifex Forel is very aggressive towards any intruder, its populous colonies tolerate the close presence of the fierce polistine wasp Polybia rejecta (F.). In French Guiana, 83.33% of the 48 P. rejecta nests recorded were found side by side with those of A. chartifex. This nesting association results in mutual protection from predators (i.e., the wasps protected from army ants; the ants protected from birds). We conducted field studies, laboratory-based behavioral experiments and chemical analyses to elucidate the mechanisms allowing the persistence of this association...
April 16, 2018: Insect Science
https://www.readbyqxmd.com/read/29658173/contrasting-results-from-gwas-and-qtl-mapping-on-wing-length-in-great-reed-warblers
#19
Bengt Hansson, Hanna Sigeman, Martin Stervander, Maja Tarka, Suvi Ponnikas, Maria Strandh, Helena Westerdahl, Dennis Hasselquist
A major goal in evolutionary biology is to understand the genetic basis of adaptive traits. In migratory birds, wing morphology is such a trait. Our previous work on the great reed warbler (Acrocephalus arundinaceus) shows that wing length is highly heritable and under sexually antagonistic selection. Moreover, a quantitative trait locus (QTL) mapping analysis detected a pronounced QTL for wing length on chromosome 2, suggesting that wing morphology is partly controlled by genes with large effects. Here, we re-evaluate the genetic basis of wing length in great reed warblers using a genome-wide association study (GWAS) approach based on restriction site-associated DNA sequencing (RADseq) data...
April 15, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29658160/-butterfly-wings-stabilize-heptacene
#20
Matthias Müller, Elias C Rüdiger, Silke Koser, Olena Tverskoy, Frank Rominger, Felix Hinkel, Jan Freudenberg, Uwe Heiko Bunz
The synthesis of bisalkynylated derivatives of tetrabenzo-[a,c,p,r]heptacene and tetrabenzo[a,c,l,n]pentacene via two-/fourfold Stille reactions involving a 9-stannafluorene and suitable tetrabromoacenes is reported. These triphenylene-"winged" hept-acenes are surprisingly stable and maintain a significant portion of the electronic properties of heptacenes.
April 15, 2018: Chemistry: a European Journal
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