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https://www.readbyqxmd.com/read/29145693/early-erythropoiesis-stimulating-agents-in-preterm-or-low-birth-weight-infants
#1
REVIEW
Arne Ohlsson, Sanjay M Aher
BACKGROUND: Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising enterocolitis (NEC). Darbepoetin (Darbe) and EPO are currently available ESAs. OBJECTIVES: To assess the effectiveness and safety of ESAs (erythropoietin (EPO) and/or Darbe) initiated early (before eight days after birth) compared with placebo or no intervention in reducing red blood cell (RBC) transfusions, adverse neurological outcomes, and feeding intolerance including necrotising enterocolitis (NEC) in preterm and/or low birth weight infants...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29142224/health-and-disease-phenotyping-in-old-age-using-a-cluster-network-analysis
#2
Jesus Felix Valenzuela, Christopher Monterola, Victor Joo Chuan Tong, Tze Pin Ng, Anis Larbi
Human ageing is a complex trait that involves the synergistic action of numerous biological processes that interact to form a complex network. Here we performed a network analysis to examine the interrelationships between physiological and psychological functions, disease, disability, quality of life, lifestyle and behavioural risk factors for ageing in a cohort of 3,270 subjects aged ≥55 years. We considered associations between numerical and categorical descriptors using effect-size measures for each variable pair and identified clusters of variables from the resulting pairwise effect-size network and minimum spanning tree...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137726/mineralized-collagen-fibril-network-spatial-arrangement-influences-cortical-bone-fracture-behavior
#3
Yaohui Wang, Ani Ural
Bone is a hierarchical material exhibiting different fracture mechanisms at each length scale. At the submicroscale, the bone is composed of mineralized collagen fibrils (MCF). At this scale, the fracture processes in cortical bone have not been extensively studied in the literature. In this study, the influence of MCF size and orientation on the fracture behavior of bone under both transverse and longitudinal loading was investigated using novel 3D models of MCF networks with explicit representation of extra-fibrillar matrix...
November 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29133834/instability-in-ch3nh3pbi3-perovskite-solar-cells-due-to-elemental-migration-and-chemical-composition-changes
#4
Zubair Ahmad, Mansoor Ani Najeeb, R A Shakoor, Abdulla Alashraf, Shaheen A Al-Muhtaseb, Ahmed Soliman, M K Nazeeruddin
Organic-inorganic halide perovskites have rapidly grown as favorable materials for photovoltaic applications, but accomplishing long-term stability is still a major research problem. This work demonstrates a new insight on instability and degradation factors in CH3NH3PbI3 perovskite solar cells aging with time in open air. X-ray photoelectron spectroscopy (XPS) has been used to investigate the compositional changes caused by device degradation over the period of 1000 hrs. XPS spectra confirm the migration of metallic ions from the bottom electrode (ITO) as a key factor causing the chemical composition change in the perovskite layer besides the diffusion of oxygen...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133089/cellulose-gum-and-copper-nanoparticles-based-hydrogel-as-antimicrobial-agents-against-urinary-tract-infection-uti-pathogens
#5
Abdullah M Al-Enizi, Tansir Ahamad, Abdullah Baker Al-Hajji, Jahangeer Ahmed, Anis Ahmad Chaudhary, Saad M Alshehri
In the present study, stable copper nanoparticles (CuNPs) were successfully prepared in the hydrogel matrix. The prepared nanocomposite (HCuNPs) was characterized via x-ray diffraction (XRD), electron microscopy (TEM), and energy-dispersive (EDX) and x-ray photoelectron spectroscopic (XPS) studies. The wide scan XPS spectra support the presence of C, N and O in neat hydrogel; while, the XPS spectra of HCuNPs demonstrate the presence of Cu along with C, N, and O elements. TEM studies show the formation of spherical shaped CuNPs in the size range from 7 to 12nm...
November 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29129008/high-levels-of-oxidized-fatty-acids-in-hdl-are-associated-with-impaired-hdl-function-in-patients-with-active-rheumatoid-arthritis
#6
Christina Charles-Schoeman, David Meriwether, Yuen Yin Lee, Ani Shahbazian, Srinivasa T Reddy
The objective of this study was to evaluate oxidation products of arachidonic acid and linoleic acid in lipoproteins and synovial fluid (SF) from patients with active rheumatoid arthritis (RA) compared to non-RA controls. High-density lipoproteins (HDL) and low-density lipoproteins (LDL) were isolated from plasma using fast protein liquid chromatography and HDL was isolated from SF using dextran sulfate precipitation. 5-Hydroxyeicosatetraenoic acid (HETE), 12-HETE, 15-HETE, 9 hydroxyoctadecadienoic (HODE), and 13-HODE levels were measured in HDL, LDL, and SF by liquid chromatography-tandem mass spectrometry...
November 11, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29128587/selection-in-mixtures-of-food-particles-during-oral-processing-in-man
#7
Hilbert W van der Glas, Esther H-J Kim, Anis Z Mustapa, Wijdan R Elmanaseer
OBJECTIVES: Two processes underlie food comminution during chewing: (1) selection, i.e. every particle has a chance of being placed between the teeth and being subjected to (2) breakage. Selection decreases with particle number by saturation of breakage sites, and it depends on competition between smaller and larger particles for breakage sites. Theoretical models were tested which describe competition between various sizes X. In the one-way model, small particles cannot compete with larger ones because of their smaller height...
October 31, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29128567/haploinsufficiency-of-hnrnp-u-changes-activity-pattern-and-metabolic-rhythms
#8
Beibei Lai, Jianghuan Zou, Zhaoyu Lin, Zhipeng Qu, Anying Song, Ying Xu, Xiang Gao
The neuropeptides arginine vasopressin (Avp) and vasoactive intestinal polypeptide (Vip) are critical for the communication and coupling of suprachiasmatic nucleus neurons, which organize daily rhythms of physiology and behavior in mammals. However, how these peptides are regulated remains uncharacterized. Here, we demonstrate that heterogeneous nuclear ribonucleoprotein U (hnRNP U) is essential for the expression of Avp and Vip. Loss of one copy of the Hnrnpu gene resulted in fragmented locomotor activities and disrupted metabolic rhythms...
November 8, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29126634/-antiepileptic-drugs-administration-by-nasogastric-tube-in-comatose-patients
#9
Rim Charfi, Ramla Mizouri, Mouna Ben Sassi, Emna Gaies, Hanene Eljebari, Nadia Jebabli, Sarrah Zereï, Fatma Ben Salem, Dorra Ben Said, Anis Klouz, Riadh Daghfous, Issam Salouage, Sameh Trabelsi
AIM: To evaluate the modalities of administration of antiepileptic drugs (AED) with nasogastric tube (NGT) by nurses and to draw up recommendations. METHODS: Our study consisted on investigating the modalities of administration of AED's with NGT by nurses during four months. We prepared 10 questions including demographic information. Participation was voluntary and anonymous. The questionnaire was distributed in seven intensive care departments after authorization of each head of the department...
October 12, 2017: Thérapie
https://www.readbyqxmd.com/read/29121287/analgesia-nociception-index-for-the-assessment-of-pain-in-critically-ill-patients-a-diagnostic-accuracy-study
#10
G Chanques, T Tarri, A Ride, A Prades, A De Jong, J Carr, N Molinari, S Jaber
Background: Behavioural pain tools are used in Intensive Care Unit (ICU) patients unable to self-report their pain-intensity but need sustained efforts to educate and train the ICU team because of the subjective nature of these clinical tools. This study measured the validity and performance of an electrophysiological monitoring tool based on the spectral analysis of heart rate variability, the Analgesia Nociception Index (ANI) which varies from 0 (minimal parasympathetic tone, maximal stress-response and pain) to 100 (maximal parasympathetic tone, minimal stress-response and pain)...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29120584/autoimmune-thyroiditis-a-case-control-study-on-a-sample-of-egyptian-type-i-diabetic-patients
#11
Hoda G Bakr, Ihab M Salem, Takwa E Meawed, Reham H Anis, Mohamed H El-Hefnawy
Type 1 diabetic patients are vulnerable for autoimmune thyroid disease. The incidence of type I Diabetes in Egypt is 8/100000. Undiagnosed thyroid dysfunction impairs metabolic status and increase cardiovascular risks in diabetic patients. Objectives of the study were to underscore autoimmune thyroiditis and thyroid dysfunction on a sample of Egyptian type I diabetes mellitus. One hundred type 1 diabetic subjects without previously known thyroid diseases and 50 controls were included. Physical examination, HbA1c, thyroid profile (TSH, free T3 and free T4), thyroid ultrasound anti-peroxidase and anti-thyroglobulin antibodies were assessed...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29119103/evaluation-of-catalytic-effects-of-chymotrypsin-and-cu-2-for-development-of-uv-spectroscopic-method-for-gelatin-source-differentiation
#12
Anis Hamizah, Ademola Monsur Hammed, Tawakalit Tope Asiyanbi-H, Mohamed Elwathig Saeed Mirghani, Irwandi Jaswir, Nurrulhidayah Binti Ahamad Fadzillah
The consumers interest in gelatin authentication is high due to allergic reactions and adoption of Halal and Kosher eating cultures. This research investigated browning development due to enzymatic hydrolysis and presence of Cu(2+) during Maillard reaction of fish, porcine, and bovine gelatin. The rate of browning index samples showed two phases-rapid and slow-for all the gelatin samples and changes in browning index (ΔBindex) were increased (>100%) in presence of Cu(2+). ΔBindex of enzymatic hydrolysates were different among the gelatin species...
2017: International journal of food science
https://www.readbyqxmd.com/read/29116040/fictibacillus-aquaticus-sp-nov-isolated-from-downstream-river-water
#13
Deepika Pal, Ayanka Bhardwaj, Navjot Kaur, Sarabjeet Kour Sudan, Bhawana Bisht, Munesh Kumari, Bhawna Vyas, Srinivasan Krishnamurthi, Shanmugam Mayilraj
A Gram-stain-positive, facultatively anaerobic bacterial strain, GDSW-R2A3(T), was isolated from a downstream water sample collected from the river Ganges, India. Analysis of the 16S rRNA gene sequence of strain GDSW-R2A3(T) revealed its affiliation to the family Bacillaceae. Further analysis using a polyphasic approach revealed that strain GDSW-R2A3(T) was most closely related to the genus Fictibacillus. Analysis of the almost-complete (1488 bp) 16S rRNA gene sequence of strain GDSW-R2A3(T) revealed the highest level of sequence similarity with Fictibacillus phosphorivorans CCM 8426(T) (98...
November 8, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29114038/aberrant-rac1-cofilin-signaling-mediates-defects-in-dendritic-spines-synaptic-function-and-sensory-perception-in-fragile-x-syndrome
#14
Alexander Pyronneau, Qionger He, Jee-Yeon Hwang, Morgan Porch, Anis Contractor, R Suzanne Zukin
Fragile X syndrome (FXS) is the most common inherited cause of intellectual disabilities and a leading cause of autism. FXS is caused by a trinucleotide expansion in the gene FMR1 on the X chromosome. The neuroanatomical hallmark of FXS is an overabundance of immature dendritic spines, a factor thought to underlie synaptic dysfunction and impaired cognition. We showed that aberrantly increased activity of the Rho GTPase Rac1 inhibited the actin-depolymerizing factor cofilin, a major determinant of dendritic spine structure, and caused disease-associated spine abnormalities in the somatosensory cortex of FXS model mice...
November 7, 2017: Science Signaling
https://www.readbyqxmd.com/read/29113407/healing-touch-in-radiation-therapy-is-the-benefit-tangible
#15
Jean-Baptiste Guy, Sacha Bard-Reboul, Jane-Chloé Trone, Alexis Vallard, Sophie Espenel, Julien Langrand-Escure, Anis Hamrouni, Majed Ben Mrad, Stéphanie Morisson, Patrick Michaud, Nicolas Magné, Chloé Rancoule
Background: Cancer patients tend to use more and more complementary or alternative medicine concomitantly to radiotherapy. A large part of these patients have recourse to Mind and Body practice, mainly with biofield healers or magnetizers, without any level of evidence. The aim of the present study was to report epidemiologic data on biofield healers in radiation therapy patients, and to assess the possible objective and subjective benefits. Materials and Methods: A retrospective study was conducted in a French cancer institute...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29111504/validation-of-the-polish-version-of-the-beck-depression-inventory-in-patients-with-epilepsy
#16
Mariusz S Wiglusz, Jerzy Landowski, Lidia Michalak, Wiesław J Cubała
BACKGROUND: Despite the fact that depressive disorders are the most common comorbidities among patients with epilepsy (PWE), such disorders often go unrecognized and untreated. In addition, the availability of validated screening instruments to detect depression in PWE is limited. The aim of the present study was thus to validate the Polish version of the Beck Depression Inventory (BDI) in adult PWE. METHODS: A group of 118 outpatient PWE were invited to participate in the study...
October 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29109156/improving-genomic-prediction-in-cassava-field-experiments-using-spatial-analysis
#17
Ani A Elias, Ismail Rabbi, Peter Kulakow, Jean-Luc Jannink
Cassava (Manihot esculenta Crantz) is an important staple food in sub-Saharan Africa. Breeding experiments were conducted at the International Institute of Tropical Agriculture in cassava to select elite parents. Taking into account the heterogeneity in the field while evaluating these trials can increase the accuracy in estimation of breeding values. We used an exploratory approach using the parametric spatial kernels Power, Spherical, and Gaussian to determine the best kernel for a given scenario. The spatial kernel was fit simultaneously with a genomic kernel in a genomic selection model...
November 6, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29106948/good-functional-outcome-but-not-regained-health-related-quality-of-life-in-the-majority-of-20-69-years-old-patients-with-femoral-neck-fracture-treated-with-internal-fixation-a-prospective-2-year-follow-up-study-of-182-patients
#18
Pierre Campenfeldt, Margareta Hedström, Wilhelmina Ekström, Amer N Al-Ani
BACKGROUND AND PURPOSE: Prospective studies on patient related outcome in patients <70years with a femoral neck fracture (FNF) are few. We aimed to investigate functional outcome and health-related quality of life (HRQoL) in 20-69years old patients with a FNF treated with internal fixation. PATIENTS AND METHODS: 182 patients, 20-69years with a FNF treated with internal fixation were prospectively included in a multicenter study. Follow up included radiographic and clinical examination at 4, 12 and 24 months...
October 18, 2017: Injury
https://www.readbyqxmd.com/read/29105628/enhanced-physical-endurance-and-improved-memory-performance-following-taurine-administration-in-rats
#19
Irfan Sajid, Saara Ahmad, Shaista Emad, Zehra Batool, Saima Khaliq, Lubna Anis, Saiqa Tabassum, Syeda Madiha, Laraib Liaquat, Sadia Sadir, Tahira Perveen, Saida Haider
Energy drinks enhance physical endurance and cognitive ability. The ingredients present in these drinks are considered as ergogenic and have memory boosting effects. In the present study effects of taurine administration for one week was monitored on physical exercise and memory performance in rats. Animals were divided into two groups namely control and test. Taurine was injected intraperitoneally to the test group at the dose of 100mg/kg. After one week of treatment rats were subjected to physical exercise and memory task...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29101765/novel-anatomic-mapping-of-pelvic-plexus-at-prostatic-and-periprostatic-region-on-fresh-frozen-cadaveric-setting
#20
Emre Huri, Mustafa F Sargon, Ilkan Tatar, Makbule Cisel Aydin, Mehmet Ezer, Figen Soylemezoglu
PURPOSE: We aimed to investigate the exact localization of neural pathway and the frequency of nerve fibers, which are located in the pelvic facial layers in the prostate and periprostatic regions. MATERIALS AND METHODS: We used four fresh frozen cadavers in this trial. Anatomical layers of anterior rectus fascia and abdominal rectus muscle were dissected to reach the retropubic area. Prostate, visceral and parietal pelvic fascia, levator ani muscle and puboprostatic ligaments were identified...
November 4, 2017: Urology Journal
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