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https://www.readbyqxmd.com/read/28327469/total-body-irradiation-with-a-compensator-fabricated-using-a-3d-optical-scanner-and-a-3d-printer
#1
So-Yeon Park, Jung-In Kim, Yoon Ha Joo, Jung Chan Lee, Jong Min Park
We propose bilateral total body irradiation (TBI) utilizing a 3D printer and a 3D optical scanner. We acquired surface information of an anthropomorphic phantom with the 3D scanner and fabricated the 3D compensator with the 3D printer, which could continuously compensate for the lateral missing tissue of an entire body from the beam's eye view. To test the system's performance, we measured doses with optically stimulated luminescent dosimeters (OSLDs) as well as EBT3 films with the anthropomorphic phantom during TBI without a compensator, conventional bilateral TBI, and TBI with the 3D compensator (3D TBI)...
March 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28325619/effects-of-online-cone-beam-computed-tomography-with-active-breath-control-in-determining-planning-target-volume-during-accelerated-partial-breast-irradiation
#2
Y Li, R Zhong, X Wang, P Ai, F Henderson, N Chen, F Luo
PURPOSE: To test if active breath control during cone-beam computed tomography (CBCT) could improve planning target volume during accelerated partial breast radiotherapy for breast cancer. METHODS: Patients who were more than 40 years old, underwent breast-conserving dissection and planned for accelerated partial breast irradiation, and with postoperative staging limited to T1-2 N0 M0, or postoperative staging T2 lesion no larger than 3cm with a negative surgical margin greater than 2mm were enrolled...
March 18, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28324056/gabaergic-neurons-and-their-modulatory-effects-on-gnrh3-in-zebrafish
#3
Yanlong Song, Binbin Tao, Ji Chen, Shaoting Jia, Zuoyan Zhu, Vance L Trudeau, Wei Hu
Gamma-aminobutyric acid (GABA) is a major amino acid neurotransmitter in the vertebrate brain. To provide detailed information on the distribution of the GABA in zebrafish (Danio rerio), neurons were labeled with mCherry driven by the glutamic acid decarboxylase 67 (gad67) promoter. In the transgenic line Tg(gad67:mCherry), mCherry-positive gad67 cell bodies were predominantly localized to the olfactory bulb, pallial zones, subpallium zones, parvocellular preoptic nucleus, periventricular gray zone of optic tectum, torus semicircularis, posterior tuberculum, medial longitudinal fascicle, caudal zone of periventricular hypothalamus, and oculomotor nucleus...
January 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323332/shedding-light-on-gray-ing-areas-connectivity-and-task-switching-dynamics-in-aging
#4
Pauline L Baniqued, Kathy A Low, Mark A Fletcher, Gabriele Gratton, Monica Fabiani
Control-demanding tasks rely on communication among regions of the frontoparietal network, areas that undergo significant age-related decline. Here, we integrate data from brain anatomy, electrophysiology (ERPs), and optical imaging (event-related optical signals, EROS) to characterize the spatial and temporal dynamics of preparatory control processes in middle to old age. Older adults participated in an experiment that required switching between a position and a meaning task (spatial Stroop), a paradigm that has been shown to primarily recruit prefrontal cortex in opposite hemispheres and is thought to involve the corpus callosum (CC)...
March 21, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28321956/mapping-the-brain-network-of-the-phonological-loop
#5
Costanza Papagno, Alessandro Comi, Marco Riva, Alberto Bizzi, Mirta Vernice, Alessandra Casarotti, Enrica Fava, Lorenzo Bello
The cortical and subcortical neural correlates underlying item and order information in verbal short-term memory (STM) were investigated by means of digit span in 29 patients with direct electrical stimulation during awake surgery for removal of a neoplastic lesion. Stimulation of left Broca's area interfered with span, producing significantly more item than order errors, as compared to the stimulation of the supramarginal/angular gyrus, which also interfered with span but, conversely, produced more order than item errors...
March 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28321373/a-review-of-skull-base-tumor-clinical-trials-past-trends-and-future-opportunities
#6
Anand Devaiah, Charles Murchison
Objective Tumors of the anterior and lateral skull base (TALSB) are relatively rare but can be devastating to patients. By examining trials focused on TALSB, we can characterize the studies that predominate and better understand current directions of study. This gives us a better understanding of future studies to pursue. Study Design This is a retrospective analysis. Settings We set skull base tumor clinical trials in the United States which are listed in ClinicalTrials.gov. Subjects and Methods We used the information available on ClinicalTrials...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28321178/post-training-inactivation-of-the-anterior-thalamic-nuclei-impairs-spatial-performance-on-the-radial-arm-maze
#7
Ryan E Harvey, Shannon M Thompson, Lilliana M Sanchez, Ryan M Yoder, Benjamin J Clark
The limbic thalamus, specifically the anterior thalamic nuclei (ATN), contains brain signals including that of head direction cells, which fire as a function of an animal's directional orientation in an environment. Recent work has suggested that this directional orientation information stemming from the ATN contributes to the generation of hippocampal and parahippocampal spatial representations, and may contribute to the establishment of unique spatial representations in radially oriented tasks such as the radial arm maze...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28320847/multivoxel-pattern-analysis-reveals-3d-place-information-in-the-human-hippocampus
#8
Misun Kim, Kate J Jeffery, Eleanor A Maguire
The spatial world is three-dimensional (3D), and humans and other animals move both horizontally and vertically within it. Extant neuroscientific studies have typically investigated spatial navigation on a horizontal two-dimensional plane, leaving much unknown about how 3D spatial information is represented in the brain. Specifically, horizontal and vertical information may be encoded in the same or different neural structures with equal or unequal sensitivity. Here, we investigated these possibilities using functional MRI (fMRI) while participants were passively moved within a 3D lattice structure as if riding a rollercoaster...
March 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28320428/a-topology-based-method-to-mitigate-the-dosimetric-uncertainty-caused-by-the-positional-variation-of-the-boost-volume-in-breast-conservative-radiotherapy
#9
Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin, An-Cheng Shiau
BACKGROUND: To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the simultaneous integrated boost (SIB) modulated technique. However, the position of tumor bed kept changing during the treatment course as the treatment position was aligned to bony anatomy. This study aimed to analyze the positional uncertainties between bony anatomy and tumor bed, and a topology-based approach was derived to stratify patients with high variation in tumor bed localization...
March 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28320209/anterolateral-ligament-of-the-knee-anatomy-function-imaging-and-treatment
#10
Ronak M Patel, Robert H Brophy
The anterolateral ligament (ALL) of the knee has gained attention recently for its potential role in rotational stability of the knee, especially in association with anterior cruciate ligament (ACL) injuries. Anatomic studies have characterized the ALL as it runs in an anteroinferior and oblique direction from the lateral distal femur to the anterolateral proximal tibia, although the prevalence and variance of this ligament are not well understood. Magnetic resonance imaging and ultrasound have identified the ligament and linked it with the classically described Segond fracture...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28320123/relationship-of-the-angle-between-the-a1-and-a2-segments-of-the-anterior-cerebral-artery-with-formation-and-rupture-of-anterior-communicating-artery-aneurysm
#11
Jingya Ye, Peidong Zheng, Muhammad Hassan, Shengnan Jiang, Jiesheng Zheng
PURPOSE: To measure the angle between A1 and A2 segments of the anterior cerebral artery and analyze the relationship of this angle with the formation and rupture of anterior communicating artery aneurysm (ACoAA). METHODS: Patients with ACoAA (n=64) and with non-ACoAA (n=187) randomly chosen were included. The A1-A2 segment angles were measured using multislice spiral computed tomography angiography. The angular dimensions and differences were recorded and compared between the ACoAA and non-ACoAA groups and the ruptured (n=23) and unruptured group (n=41)...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319879/how-can-we-explain-the-frontal-presentation-of-insular-lobe-epilepsy-the-impact-of-non-linear-analysis-of-insular-seizures
#12
Koichi Hagiwara, Julien Jung, Romain Bouet, Chifaou Abdallah, Marc Guénot, Luis Garcia-Larrea, François Mauguière, Sylvain Rheims, Jean Isnard
OBJECTIVE: For a decade it has been known that the insular lobe epilepsy can mimic frontal lobe epilepsy. We aimed to clarify the pattern of functional coupling occurring during the frontal presentation. METHODS: We analyzed five insular lobe epilepsy patients. Frontal semiology was predominant for three of them, whereas insular semiology was predominant for the two others. We applied the non-linear regression analysis to stereoelectroencephalography-recorded seizures...
February 13, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28319240/two-paradigms-for-endovascular-thrombectomy-after-intravenous-thrombolysis-for-acute-ischemic-stroke
#13
Gaspard Gerschenfeld, Ioan-Paul Muresan, Raphael Blanc, Michael Obadia, Marie Abrivard, Michel Piotin, Sonia Alamowitch
Importance: Intravenous thrombolysis (IVT) followed by mechanical thrombectomy (MT) is recommended to treat acute ischemic stroke (AIS) with a large vessel occlusion (LVO). Most hospitals do not have on-site MT facilities, and most patients need to be transferred secondarily after IVT (drip and ship), which may have an effect on the neurologic outcome. Objective: To compare the functional independence at 3 months between patients treated under the drip-and-ship paradigm and those treated on site (mothership)...
March 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28318604/comparison-of-whole-body-vertical-stiffness-and-leg-stiffness-during-single-leg-hopping-in-place-in-children-and-adults
#14
Matthew Beerse, Jianhua Wu
In the hopping literature, whole-body vertical stiffness and leg stiffness are used interchangeably, due to most of the movement occurring in the vertical direction. However, there is some anterior/posterior movement of the center of mass and displacements of the foot during hopping in place in both children and adults. Further it is not understood if leg stiffness show a similar pattern as whole-body vertical stiffness when increasing hopping frequency. The purpose of this study was to test if whole-body vertical stiffness and leg stiffness are different during single-leg hopping in-place in children and adults, across a range of frequencies...
March 9, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28318074/perforating-and-deep-lymphatic-vessels-in-the-knee-region-an-anatomical-study-and-clinical-implications
#15
Wei-Ren Pan, Fan-Qiang Zeng, De-Guang Wang, Zhi-Qiang Qiu
BACKGROUND: To determine the relationship between the perforating and deep lymphatic vessels in the knee region for clinical implications. METHODS: Four lower limbs from two unembalmed human cadavers were used. Under a surgical microscope, 6% hydrogen peroxide was employed to detect lymph vessels accompanying the small saphenous vein, anterior tibial, posterior tibial and fibular blood vessels all commencing from distal ends of specimens. Each lymphatic vessel was inserted by a 30-gauge needle and injected with a barium sulphate mixture...
March 20, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28314439/reversing-the-atypical-valuation-of-drug-and-nondrug-rewards-in-smokers-using-multimodal-neuroimaging
#16
Travis E Baker, Paul Lesperance, Alan Tucholka, Stephane Potvin, Kevin Larcher, Yu Zhang, Didier Jutras-Aswad, Patricia Conrod
BACKGROUND: Chronic substance use can disrupt the reward function of the anterior cingulate cortex (ACC), biasing the ACC to favor goal-directed behaviors that converge on drug use. Here we used multimodal neuroimaging methods to ask whether modulating reward-related signaling in the ACC can reverse the atypical valuation of nondrug and drug rewards in abstinent smokers. METHODS: We first recorded functional magnetic resonance imaging data from 20 moderately dependent cigarette smokers (mean age = 25 years; no history of neuropsychiatric disorders), following an overnight period of abstinence, to identify regions of the left dorsal lateral prefrontal cortex associated with the anticipation of drug-related rewards (cigarette puff)...
January 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28314202/the-relation-between-parent-depressive-symptoms-and-neural-correlates-of-attentional-control-in-offspring-a-preliminary-study
#17
Katie L Burkhouse, Autumn Kujawa, Kate Keenan, Heide Klumpp, Kate D Fitzgerald, Christopher S Monk, K Luan Phan
Offspring of depressed parents are at significantly elevated risk for depressive disorders themselves; however, the specific mechanisms associated with this risk are not well known. Given the well-established link between parental depression and biased attention for negative stimuli in children, this preliminary study sought to examine the neural correlates of directing attention toward and away from emotional faces in children and adolescents in association with parent's current depressive symptoms. Forty-two youth (age 7-18 years) completed a task with conditions that manipulated whether participants were instructed to match emotional faces (explicit emotion processing) or match shapes in the context of emotional face distractors (implicit emotion processing) during functional magnetic resonance imaging...
March 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28303455/duodenal-cancer-in-a-young-patient-with-peuts-jeghers-syndrome-harboring-an-entire-deletion-of-the-stk11-gene
#18
Satoshi Teramae, Koichi Okamoto, Kumiko Tanaka, Reika Matsumoto, Shinji Kitamura, Tetsuo Kimura, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma, Yoshimi Bando, Mitsuo Shimada, Tetsuji Takayama
A 21-year-old woman with Peuts-Jeghers syndrome (PJS) was referred to our hospital for gastrointestinal surveillance. She had been diagnosed as having PJS from a young age based on her family history and the presence of mucocutaneous pigmentation on her lips and oral mucosa. Her mother and brother had PJS harboring an entire deletion of the STK11 gene. She had tetralogy of Fallot, atrial tachycardia, sick sinus syndrome, and mental retardation in her past history. Esophagogastroduodenoscopy identified a protruded lesion with a depressed area that occupied the lumen half-circumferentially in the duodenal second portion and also showed a 10-mm protruded lesion on the anterior wall of the lower gastric body...
March 16, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28301224/increased-risk-of-revision-after-anterior-cruciate-ligament-reconstruction-with-soft-tissue-allografts-compared-with-autografts-graft-processing-and-time-make-a-difference
#19
Gregory B Maletis, Jason Chen, Maria C S Inacio, Rebecca M Love, Tadashi T Funahashi
BACKGROUND: The optimal graft for anterior cruciate ligament reconstruction (ACLR) remains controversial. PURPOSE: To compare the risk of aseptic revision between bone-patellar tendon-bone (BPTB) autografts, hamstring autografts, and soft tissue allografts. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: Prospectively collected ACLR cases reconstructed with BPTB autografts, hamstring autografts, and soft tissue allografts were identified using the Kaiser Permanente ACLR Registry...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28300743/four-dimensional-microscope-integrated-optical-coherence-tomography-to-enhance-visualization-in-glaucoma-surgeries
#20
Neel Dave Pasricha, Paramjit Kaur Bhullar, Christine Shieh, Christian Viehland, Oscar Mijail Carrasco-Zevallos, Brenton Keller, Joseph Adam Izatt, Cynthia Ann Toth, Pratap Challa, Anthony Nanlin Kuo
We report the first use of swept-source microscope-integrated optical coherence tomography (SS-MIOCT) capable of live four-dimensional (4D) (three-dimensional across time) imaging intraoperatively to directly visualize tube shunt placement and trabeculectomy surgeries in two patients with severe open-angle glaucoma and elevated intraocular pressure (IOP) that was not adequately managed by medical intervention or prior surgery. We performed tube shunt placement and trabeculectomy surgery and used SS-MIOCT to visualize and record surgical steps that benefitted from the enhanced visualization...
January 2017: Indian Journal of Ophthalmology
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