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https://www.readbyqxmd.com/read/28651178/the-influence-of-impact-direction-and-axial-loading-on-the-bone-fracture-pattern
#1
Haim Cohen, Chen Kugel, Hila May, Bahaa Medlej, Dan Stein, Viviane Slon, Tamar Brosh, Israel Hershkovitz
The effect of the direction of the impact and the presence of axial loading on fracture patterns have not yet been established in experimental 3-point bending studies. PURPOSE: To reveal the association between the direction of the force and the fracture pattern, with and without axial loading. MATERIAL AND METHODS: A Dynatup Model POE 2000 (Instron Co.) low energy pendulum impact machine was utilized to apply impact loading on fresh pig femoral bones (n=50). The bone clamp shaft was adjusted to position the bone for three-point bending with and without additional bone compression...
May 22, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28649493/voluntary-saccade-inhibition-deficits-correlate-with-extended-white-matter-cortico-basal-atrophy-in-huntington-s-disease
#2
Israel Vaca-Palomares, Brian C Coe, Donald C Brien, Douglas P Munoz, Juan Fernandez-Ruiz
The ability to inhibit automatic versus voluntary saccade commands in demanding situations can be impaired in neurodegenerative diseases such as Huntington's disease (HD). These deficits could result from disruptions in the interaction between basal ganglia and the saccade control system. To investigate voluntary oculomotor control deficits related to the cortico-basal circuitry, we evaluated early HD patients using an interleaved pro- and anti-saccade task that requires flexible executive control to generate either an automatic response (look at a peripheral visual stimulus) or a voluntary response (look away from the stimulus in the opposite direction)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28648759/epha2-and-ephrin-a5-are-not-a-receptor-ligand-pair-in-the-ocular-lens
#3
Catherine Cheng, Velia M Fowler, Xiaohua Gong
Eph-ephrin bidirectional signaling is essential for eye lens transparency in humans and mice. Our previous studies in mouse lenses demonstrate that ephrin-A5 is mainly expressed in the anterior epithelium, where it is required for maintaining the anterior epithelial monolayer. In contrast, EphA2 is localized in equatorial epithelial and fiber cells where it is essential for equatorial epithelial and fiber cell organization and hexagonal cell shape. Immunostaining of lens epithelial and fiber cells reveals that EphA2 and ephrin-A5 are also co-expressed in anterior fiber cell tips, equatorial epithelial cells and newly formed lens fibers, although they are not precisely colocalized...
June 22, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28647641/impact-of-left-subclavian-artery-revascularization-prior-to-thoracic-endovascular-aortic-repair-on-post-operative-cerebrovascular-hemodynamics
#4
Arnoud V Kamman, Jonathan L Eliason, David M Williams, Bo Yang, Frans L Moll, Santi Trimarchi, Kim A Eagle, Himanshu J Patel
OBJECTIVES: The impact of left subclavian artery (LSA) revascularization prior to thoracic endovascular aortic repair (TEVAR) on cerebrovascular flow is not well described. We studied bilateral vertebral and carotid artery flow characteristics before and after TEVAR, to evaluate the hemodynamic effects of LSA revascularization. METHODS: Seventy-four patients with mixed etiologies (mean age 70.9±10.5 years) underwent LSA revascularization and TEVAR (2006-2016) and had available pre- and post-operative carotid Duplex study available...
June 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647325/the-processing-of-semantic-relatedness-in-the-brain-evidence-from-associative-and-categorical-false-recognition-effects-following-transcranial-direct-current-stimulation-of-the-left-anterior-temporal-lobe
#5
Emiliano Díez, Carlos J Gómez-Ariza, Antonio M Díez-Álamo, María A Alonso, Angel Fernandez
A dominant view of the role of the anterior temporal lobe (ATL) in semantic memory is that it serves as an integration hub, specialized in the processing of semantic relatedness by way of mechanisms that bind together information from different brain areas to form coherent amodal representations of concepts. Two recent experiments, using brain stimulation techniques along with the Deese-Roediger-McDermott (DRM) paradigm, have found a consistent false memory reduction effect following stimulation of the ATL, pointing to the importance of the ATL in semantic/conceptual processing...
June 3, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28646532/acquired-bilateral-telangiectasia-macularis-eruptiva-perstans-a-unique-clinical-feature-of-photodamaging-rather-than-a-subtype-of-cutaneous-mastocytosis
#6
Hye-Rim Moon, Young Jae Kim, Joon Min Jung, Chong Hyun Won, Mi Woo Lee, Jee Ho Choi, Sung Eun Chang
Telangiectasia macularis eruptiva perstans (TMEP) is a rare subtype of cutaneous mastocytosis, characterized by telangiectatic tan to brown macules on the trunk and extremities. Although TMEP has been descried as an uncommon disease in the literature, we often encounter patients with TMEP lesions in the outpatient clinic. We aimed to assess the clinical and histopathological characteristics of acquired bilateral TMEP, and the pathophysiological mechanism of acquired bilateral TMEP among these patients. We retrospectively reviewed 30 patients (28 men and 2 women) with acquired bilateral TMEP; multiple telangiectatic dark red to brown macules that were symmetrically distributed...
June 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28644737/circulatory-cnp-rescues-craniofacial-hypoplasia-in-achondroplasia
#7
S Yamanaka, Kazumasa Nakao, N Koyama, Y Isobe, Y Ueda, Y Kanai, E Kondo, T Fujii, M Miura, A Yasoda, Kazuwa Nakao, K Bessho
Achondroplasia is the most common genetic form of human dwarfism, characterized by midfacial hypoplasia resulting in occlusal abnormality and foramen magnum stenosis, leading to serious neurologic complications and hydrocephalus. Currently, surgery is the only way to manage jaw deformity, neurologic complications, and hydrocephalus in patients with achondroplasia. We previously showed that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth of long bones and vertebrae and is also a potent stimulator in the craniofacial region, which is crucial for midfacial skeletogenesis...
June 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28644578/the-chorda-tympani-retractor-in-stapedectomy
#8
Gaurav Chawdhary, Jeremy Lavy
The chorda tympani is at risk during stapedectomy and evidence suggests a significant proportion of patients experience postoperative taste disturbance(1,2,3) . It is therefore important to minimise this risk by preserving the nerve and limiting unnecessary manipulation. In some patients the anatomy may place the nerve directly in the way of the surgical field, making this difficult to achieve. Here we describe a simple way to retract the chorda tympani anteriorly and keep it held away while performing stapedectomy...
June 23, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28643569/iron-overload-directly-affecting-the-ovaries-in-a-patient-with-diamond-blackfan-anaemia-a-case-report
#9
Mariano Mascarenhas, Victoria Rawnsley, Adam Balen
Iron is a 'one-way' element and the primary point of regulation of body iron stores is at the level of intestinal iron absorption. Repeated blood transfusions for congenital anaemias bypass this regulatory checkpoint and inevitably lead to iron overload in the long-term. Iron overload causes multi-organ dysfunction of the heart, liver, pancreas and joints. It also causes reproductive toxicity primarily through its damaging effect on the anterior pituitary leading to hypogonadotrophic hypogonadism. Another less understood mechanism of reproductive toxicity is direct gonadal damage of excess free iron...
June 23, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28642285/state-dependent-tms-reveals-representation-of-affective-body-movements-in-the-anterior-intraparietal-cortex
#10
Noemi Mazzoni, Christianne Jacobs, Paola Venuti, Juha Silvanto, Luigi Cattaneo
In humans, recognition of others' actions involves a cortical network that comprises, among other cortical regions, the posterior superior temporal sulcus (pSTS), where biological motion is coded and the anterior intraparietal suclus (aIPS), where movement information is elaborated in terms of meaningful goal-directed actions. This action observation system (AOS) is thought to encode neutral voluntary actions, and possibly some aspects of affective motor repertoire, but the role of the AOS' areas in processing affective kinematic information has never been examined...
June 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28641967/fluoroscopically-guided-acetabular-component-positioning-does-it-reduce-the-risk-of-malpositioning-in-obese-patients
#11
Raul G Gosthe, Juan C Suarez, Colin A McNamara, Cecilia Calvo, Preetesh D Patel
BACKGROUND: Obesity has been described as an independent risk factor for acetabular component malpositioning. The purpose of this study was to determine if this could be overcome by use of fluoroscopic navigation in total hip arthroplasty (THA). METHODS: The first, postoperative, standing, anteroposterior pelvis radiographs from 1599 consecutive patients who underwent fluoroscopic-guided THAs via anterior approach during a six-year period were obtained. We retrospectively reviewed this prospectively collected data...
May 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28641736/a-comprehensive-rehabilitation-program-for-posterior-instability-of-the-shoulder
#12
Lyn Watson, Simon Balster, Sarah Ann Warby, Jackie Sadi, Greg Hoy, Tania Pizzari
Posterior shoulder instability is recognised as being less prevalent than anterior instability, however the diagnosis of this pathology is easily overlooked or missed and this may contribute to an underestimation of prevalence. Recently, there has been increasing recognition of this condition and consequently a greater requirement for knowledge of diagnostic procedures and treatment directions. Currently there is limited research into the conservative management of posterior instability, although it is recommended as first-line treatment prior to surgical review, particularly in those with an atraumatic instability mechanism...
April 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28641160/effects-of-hip-joint-centre-mislocation-on-gait-kinematics-of-children-with-cerebral-palsy-calculated-using-patient-specific-direct-and-inverse-kinematic-models
#13
Hans Kainz, Christopher P Carty, Sheanna Maine, Henry P J Walsh, David G Lloyd, Luca Modenese
Joint kinematics can be calculated by Direct Kinematics (DK), which is used in most clinical gait laboratories, or Inverse Kinematics (IK), which is mainly used for musculoskeletal research. In both approaches, joint centre locations are required to compute joint angles. The hip joint centre (HJC) in DK models can be estimated using predictive or functional methods, while in IK models can be obtained by scaling generic models. The aim of the current study was to systematically investigate the impact of HJC location errors on lower limb joint kinematics of a clinical population using DK and IK approaches...
June 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28638715/rat-intersubjective-decisions-are-encoded-by-frequency-specific-oscillatory-contexts
#14
Jana Schaich Borg, Sanvesh Srivastava, Lizhen Lin, Joseph Heffner, David Dunson, Kafui Dzirasa, Luis de Lecea
INTRODUCTION: It is unknown how the brain coordinates decisions to withstand personal costs in order to prevent other individuals' distress. Here we test whether local field potential (LFP) oscillations between brain regions create "neural contexts" that select specific brain functions and encode the outcomes of these types of intersubjective decisions. METHODS: Rats participated in an "Intersubjective Avoidance Test" (IAT) that tested rats' willingness to enter an innately aversive chamber to prevent another rat from getting shocked...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638494/an-unusual-case-of-live-caesarean-scar-ectopic-pregnancy-a-common-entity-in-an-uncommon-location
#15
Sayali D Joshi, Shenaz A Momin, Dev Shetty
BACKGROUND: Scar pregnancy is an extremely rare type of ectopic pregnancy, where there is implantation of the gestational sac onto the anterior wall of the uterus at the site of previous LSCS scar in a multipara female. Due to a poor vascular supply to the lower uterine segment, caesarean scars may heal improperly predisposing it to be a site of improper implantation of the gestational sac. RESULTS: The characteristic features are empty uterus and cervix, gestational sac in the anterior part of lower uterine segment with a history of painless vaginal bleeding...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28638289/diagnosis-and-treatment-of-hereditary-hemorrhagic-telangiectasia
#16
REVIEW
Cameron Grigg, Daniel Anderson, James Earnshaw
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disorder known for its debilitating symptoms. More than 90% of patients with HHT experience epistaxis, and they average up to 18 bleeds per month. We review the current literature on the pathophysiology, clinical presentation, and management of HHT. METHODS: We searched MEDLINE, EMBASE, and PubMed and identified 19 articles published since 2000 with current information on HHT. RESULTS: HHT is a disease more commonly associated with significant morbidity rather than mortality...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28637596/y-balance-test-has-no-correlation-with-the-stability-index-of-the-biodex-balance-system
#17
Gabriel Peixoto Leão Almeida, Isabel Oliveira Monteiro, Débora Fortes Marizeiro, Laísa Braga Maia, Pedro Olavo de Paula Lima
STUDY DESIGN: A cross-sectional study design. BACKGROUND: The Stability Index of the Biodex Balance System (SI-BBS) and Y Balance Test (YBT) has been used in studies assessing postural stability but no studies have verified the association of the YBT with the SI-BBS. OBJECTIVE: To analyze the association of the Y Balance Test (YBT) with the Stability Index of the Biodex Balance System (SI-BBS) to evaluate postural stability. METHODS: Forty participants who engaged in recreational physical activities, 12 of whom had a history of injury to the lower limbs...
February 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28636530/gamma-analysis-with-a-gamma-criterion-of-2-1-mm-for-stereotactic-ablative-radiotherapy-delivered-with-volumetric-modulated-arc-therapy-technique-a-single-institution-experience
#18
Jung-In Kim, Minsoo Chun, Hong-Gyun Wu, Eui Kyu Chie, Hak Jae Kim, Jin Ho Kim, Jong Min Park
To report a single-institution experience of gamma evaluations with 2%/1 mm for stereotactic ablative radiotherapy (SABR) delivered with volumetric modulated arc therapy (VMAT) technique, from January 2014 to January 2016. A total of 168 SABR VMAT plans were analyzed with a gamma criterion of 2%/1 mm, a threshold value of 10%, and a tolerance level of 90%. Of the 168 cases, four cases failed with 2%/1 mm. The average passing rate was 97.0% ± 2.5%. Three of the four failed cases showed passing rates higher than 90%, which was achieved by shifting the measuring device by 1 mm in the left-to-right or anterior-to-posterior directions...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28635238/-comparison-of-vacuum-bag-fixation-and-orfit-rack-with-thermoplastic-membrane-fixation-for-image-guided-cervical-cancer-radiotherapy
#19
Y B Li, Y L Wang, Y H Zhuo
Objective: To compare the difference of displacement between the vacuum bag fixation and the Orfit rack with thermoplastic membrane fixation of the cervical cancer patients, and to explore the individual fixation of the patients. Methods: We retrospectively analyzed the clinical data of 66 patients diagnosed as cervical cancer in Zhangzhou Municipal Hospital of Fujian Province from December 2014 to April 2016. Among them, 33 patients were fixed with vacuum bag, 33 patients were fixed with the Orfit rack with thermoplastic membrane...
June 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28633768/comparing-different-surgical-techniques-for-addressing-the-posterior-malleolus-in-supination-external-rotation-ankle-fractures-and-the-need-for-syndesmotic-screw-fixation
#20
Mengnai Li, Rachel C Collier, Brian W Hill, Nathaniel Slinkard, Thuan V Ly
Trimalleolar ankle fractures are unstable injuries with possible syndesmotic disruption. Recent data have described inherent morbidity associated with screw fixation of the syndesmosis, including the potential for malreduction, hardware irritation, and post-traumatic arthritis. The posterior malleolus is an important soft tissue attachment for the posterior inferior syndesmosis ligament. We hypothesized that fixation of a sizable posterior malleolar (PM) fracture in supination external rotation type IV (SER IV) ankle fractures would act to stabilize the syndesmosis and minimize or eliminate the need for trans-syndesmotic fixation...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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