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JOURNAL ARTICLE
Grant Victor, Bradley Ray, Dennis P Watson
BACKGROUND: Due to the considerably heightened risk of overdose immediately following jail or prison release, expansion of harm reduction interventions for citizens returning to the community after an incarceration episode should be of utmost concern. However, there are no studies examining the adoption and use of harm reduction among this population. This short report examines the use of individual-level harm reduction strategies (HRS) among people who use drugs, comparing those who have lifetime histories of incarceration with those who do not...
April 17, 2024: J Subst Use Addict Treat
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JOURNAL ARTICLE
Liam Browning, Ciara N Cannoy, Tabitha E H Moses, Leslie H Lundahl, David M Ledgerwood, Mark K Greenwald
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is highly prevalent and associated with opioid use disorder (OUD). Yet, little is known about the mechanisms by which ADHD (which is a heterogeneous construct/diagnosis) might alter the trajectory of OUD outcomes in persons who use heroin. AIM: We examined whether ADHD subtypes are related to heroin-use consequences and the extent to which the effects of ADHD on lifetime heroin-use consequences are mediated by two impulsivity factors that may be partly independent of ADHD: foreshortened time perspective and drug-use impulsivity...
April 13, 2024: Drug and Alcohol Dependence
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JOURNAL ARTICLE
Emily Pasman, Guijin Lee, Samantha Singer, Nick Burson, Elizabeth Agius, Stella M Resko
Background: Peer recovery specialists (PRSs) are substance use service providers with lived experience in recovery. Although a large body of research demonstrates the efficacy of medications for opioid use disorder (MOUD), emerging research suggests PRSs' attitudes toward MOUD are ambivalent or mixed. Few studies have quantitatively assessed factors influencing PRSs' attitudes. Objectives: This study identifies personal and professional characteristics associated with attitudes toward MOUD among PRSs. Methods: PRSs working at publicly funded agencies in Michigan completed a self-administered web-based survey ( N = 266, 60...
April 19, 2024: American Journal of Drug and Alcohol Abuse
#24
JOURNAL ARTICLE
James Zhang, Florence Bradshaw, Michal Duchniewicz, Fernanda W Fernandes, Rahul Geetala, Matjia Krkovic
Introduction Understanding the different opioid pain relief requirements between patients with upper limb fractures can be useful in forming specific evidence-based guidelines and balancing patient-clinician prescribing discussions with opioid stewardship. We investigated the predictors for opioid requirements in upper limb fractures. Methods We retrospectively investigated all upper limb fractures from the shoulder to the wrist treated at a major trauma center from January 2015 to January 2022. The data collected consisted of fracture location, demographics, comorbidities, and management options...
March 2024: Curēus
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JOURNAL ARTICLE
Kevin Wenzel, Julia Thomas, Jennifer Carrano, Jennifer Stidham, Marc Fishman
BACKGROUND: Extended-release naltrexone (XR-NTX) is an important treatment option for individuals with opioid use disorder (OUD) and/or alcohol use disorder (AUD). However, problems with retention are a major barrier to its overall effectiveness, and interventions to improve adherence are underdeveloped. The purpose of this study was to pilot test the MAT-PLUS intervention, which combines assertive outreach and involvement of a treatment significant other (TSO) to improve adherence to XR-NTX...
April 15, 2024: J Subst Use Addict Treat
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JOURNAL ARTICLE
Neşe Burcu Bal, Bahar Yeşil Örnek
AIMS: This study seeks to investigate ADHD symptoms and impulsivity among individuals diagnosed with Opioid Use Disorder (OUD) who also exhibit symptoms of Problematic Internet Use (PIU). METHODS: The study involved the participation of 360 Opioid Use Disorder (OUD) patients enrolled at an Alcohol and Drug Addiction Treatment Center (ADATC) during the period from October to December 2022. Various assessment tools were administered, including Young's Internet Addiction Scale (YIAS), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Barratt Impulsiveness Scale (BIS), and Adult ADHD Self-Report Scale (ASRS)...
April 18, 2024: Revista Brasileira de Psiquiatria
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JOURNAL ARTICLE
Victor Garcia, Lisa McCann, Erick Lauber, Christian Vaccaro, Melissa Swauger, Daniel Alex Heckert
Introduction : Research indicates that take-home naloxone (THN) is saving lives across rural Appalachia, but whether it also results in treatment for opioid use disorders (OUDs) remains unclear. This study involves a detailed qualitative analysis of interviews with 16 individuals who had overdosed on opioids 61 times to understand why a THN intervention does not routinely lead to OUD treatment. Methods : This study builds upon a one-year (2018) qualitative study on community responses to opioid overdose fatalities in four adjacent rural counties in Western Pennsylvania...
April 18, 2024: Substance Use & Misuse
#28
Synthia Lay, Long L Nguyen, Arul Sangani
In this case report, we present an 82-year-old female who was diagnosed with catatonia after she exhibited immobility, mutism, withdrawal, and stereotypy during a hospitalization for altered mental status. Fentanyl was found in her urine toxicology, and it was later discovered that she had been taking non-prescription pills from Mexico that were likely the source of the fentanyl. Her catatonia quickly remitted with benzodiazepine treatment. This case underscores previously unknown risks of substance use, which has grown especially important to psychiatric care considering how rampant the opioid epidemic has become...
March 2024: Curēus
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JOURNAL ARTICLE
Akosua B Dankwah, Richard B Siegrist, Ira B Wilson, Michelle McKenzie, Josiah D Rich
INTRODUCTION: Black American Christian church leaders are trusted community members and can be invaluable leaders and planners, listeners, and counselors for Opioid Use Disorder (OUD) sufferers in the opioid overdose crisis disproportionately affecting the Black community. This qualitative study examines the extent to which the knowledge, attitudes, practices, and beliefs of Black American church leaders support medical and harm reduction interventions for people with OUD. METHODS: A semi-structured interview guide was used to conduct in-depth interviews of 30 Black Rhode Island church leaders recruited by convenience and snowball sampling...
2024: Frontiers in Psychiatry
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JOURNAL ARTICLE
Neia S Prata Menezes, Shruti H Mehta, Amy Wesolowski, Steven J Clipman, Aylur K Srikrishnan, Muniratnam S Kumar, Katie J C Zook, Gregory M Lucas, Carl Latkin, Sunil S Solomon
INTRODUCTION: Injection drug networks may influence their network members' health-seeking behaviours. Using data from a sociometric injecting partner network of people who inject drugs (PWID) in New Delhi, India, we assessed the role of injecting partner (alter) behaviours on individual engagement in HIV prevention services. METHODS: We enumerated injecting partner linkages among 2512 PWID using coupon referrals and biometric data from November 2017 to March 2020...
April 2024: Journal of the International AIDS Society
#31
JOURNAL ARTICLE
Romain Sonneville, Camille Couffignal, Florian Sigaud, Virginie Godard, Juliette Audibert, Damien Contou, Adam Celier, Michel Djibre, Julien Schmidt, Pierre Jaquet, Armand Mekontso Dessap, Claire Bourel, Romane Bellot, Carine Roy, Fariza Lamara, Fatiha Essardy, Jean-François Timsit, Renaud Cornic, Lila Bouadma
INTRODUCTION: Physical restraint (PR) is prescribed in patients receiving invasive mechanical ventilation in the intensive care unit (ICU) to avoid unplanned removal of medical devices. However, it is associated with an increased risk of delirium. We hypothesise that a restrictive use of PR, as compared with a systematic use, could reduce the duration of delirium in ICU patients receiving invasive mechanical ventilation. METHODS AND ANALYSIS: The Restrictive use of Restraints and Delirium Duration in ICU (R2D2-ICU) study is a national multicentric, parallel-group, randomised (1:1) open-label, controlled, superiority trial, which will be conducted in 10 ICUs...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Andreas Markoulidakis, Matthew Hickman, Andrew McAuley, Lee R Barnsdale, Nicky J Welton, Megan Glancy, Tara Shivaji, Craig Collins, Jaroslaw Lang, Femke de Wit, Gordon Hunt, Levin Wilkinson, Rosalyn Fraser, Alan Yeung, Kirsten Horsburgh, Saket Priyadarshi, Sharon J Hutchinson, Hayley E Jones
BACKGROUND AND AIMS: Drug-related deaths in Scotland more than doubled between 2011 and 2020. To inform policymakers and understand drivers of this increase, we estimated the number of people with opioid dependence aged 15-64 from 2014/15 to 2019/20. DESIGN: We fitted a Bayesian multi-parameter estimation of prevalence (MPEP) model, using adverse event rates to estimate prevalence of opioid dependence jointly from Opioid Agonist Therapy (OAT), opioid-related mortality and hospital admissions data...
April 17, 2024: Addiction
#33
JOURNAL ARTICLE
Ewa Galaj, Guo-Hua Bi, Zheng-Xiong Xi
A growing body of research indicates that β-caryophyllene (BCP), a constituent present in a large number of plants, possesses significant therapeutic properties against CNS disorders, including alcohol and psychostimulant use disorders. However, it is unknown whether BCP has similar therapeutic potential for opioid use disorders. In this study, we found that systemic administration of BCP dose-dependently reduced heroin self-administration in rats under an FR2 schedule of reinforcement and partially blocked heroin-enhanced brain stimulation reward in DAT-cre mice, maintained by optical stimulation of midbrain dopamine neurons at high frequencies...
April 15, 2024: Neuropharmacology
#34
REVIEW
Jeremy Weleff, Julio C Nunes, Gabriel P A Costa, Mehmet Sofuoglu, R Ross MacLean, Joao P De Aquino
The rise of psychedelics in contemporary medicine has sparked interest in their potential therapeutic applications. While traditionally associated with countercultural movements and recreational use, recent research has shed light on the potential benefits of psychedelics in various mental health conditions. In this review, we explore the possible role of psychedelics in the management of chronic pain and opioid use disorder (OUD), 2 critical areas in need of innovative treatment options. Pain control remains a significant clinical challenge, particularly for individuals with OUD and those who receive long-term opioid therapy who develop marked tolerance to opioid-induced analgesia...
April 16, 2024: British Journal of Clinical Pharmacology
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JOURNAL ARTICLE
Danil Gamboa, Saranda Kabashi, Benedicte Jørgenrud, Anners Lerdal, Gudmund Nordby, Stig Tore Bogstrand
BACKGROUND: Hospital length-of-stay and admission frequency are commonly used indicators of disease burden and health resource expenditures. However, the impact of psychoactive prescription medication use and harmful alcohol consumption on both the duration and frequency of hospital admissions is under-explored. METHODS: We conducted an analysis of data gathered from 2872 patients admitted to the Emergency Department at Lovisenberg Diaconal Hospital in Oslo, Norway...
April 16, 2024: BMC Emergency Medicine
#36
JOURNAL ARTICLE
Mark A Strand, Oliver Frenzel
OBJECTIVE: The Opioid and Naloxone Education (ONE) Program focuses on community pharmacy-based patient screening and interventions to improve population health with regard to opioid use. The purpose of this paper is to reevaluate the ONE Program performance using the RE-AIM model, in comparison to the review performed in 2019. METHODS: The program performance of the ONE Program was evaluated from January 1, 2021 to December 31, 2022 was evaluated using the five domains of the RE-AIM model...
April 11, 2024: Research in Social & Administrative Pharmacy: RSAP
#37
JOURNAL ARTICLE
Teresa Nguyen, Julia Bareham, Katelyn Halpape
OBJECTIVE: To explore barriers and facilitators for family physicians in Saskatchewan prescribing opioid agonist therapy (OAT). DESIGN: Self-administered postal survey. SETTING: Family medicine practices in Saskatchewan. PARTICIPANTS: A total of 218 Saskatchewan family physicians who were not authorized to prescribe OAT as of June 2022. MAIN OUTCOME MEASURES: Descriptive and inferential statistics of physicians' self-reported barriers to and facilitators of prescribing OAT for opioid use disorder (OUD)...
April 2024: Canadian Family Physician Médecin de Famille Canadien
#38
JOURNAL ARTICLE
Charles Beldena, Albert Kopaka, Courtney Coulesa, Tessa Friesena, Justin Hallb, Shuchin Shuklaa
INTRODUCTION: Despite sustained efforts to reduce opioid-related overdose fatalities, rates have continued to rise. In many areas, overdose response involves emergency medical service (EMS) personnel administering naloxone and transporting patients to the emergency department (ED). However, a substantial number of patients decline transport, and many EDs do not provide medication for opioid use disorder (MOUD). One approach to filling this gap involves delivering MOUD to overdose patients in the field with trained post-overdose EMS teams who can initiate buprenorphine...
April 14, 2024: J Subst Use Addict Treat
#39
JOURNAL ARTICLE
LaShawn Glasgow, Christian Douglas, Joel G Sprunger, Aimee N C Campbell, Redonna Chandler, Anindita Dasgupta, JaNae Holloway, Katherine R Marks, Sara M Roberts, Linda Sprague Martinez, Katherine Thompson, Roger D Weiss, Arnie Aldridge, Kat Asman, Carolina Barbosa, Derek Blevins, Deborah Chassler, Lindsay Cogan, Laura Fanucchi, Megan E Hall, Timothy Hunt, Elizabeth Jadovich, Frances R Levin, Patricia Lincourt, Michelle R Lofwall, Vanessa Loukas, Ann Scheck McAlearney, Edward Nunes, Emmanuel Oga, Devin Oller, Maria Rudorf, Ann Marie Sullivan, Jeffery Talbert, Angela Taylor, Julie Teater, Nathan Vandergrift, Kristin Woodlock, Gary A Zarkin, Bridget Freisthler, Jeffrey H Samet, Sharon L Walsh, Nabila El-Bassel
BACKGROUND: The U.S. opioid overdose crisis persists. Outpatient behavioral health services (BHS) are essential components of a comprehensive response to opioid use disorder and overdose fatalities. The Helping to End Addiction Long-Term® (HEALing) Communities Study developed the Communities That HEAL (CTH) intervention to reduce opioid overdose deaths in 67 communities in Kentucky, Ohio, New York, and Massachusetts through the implementation of evidence-based practices (EBPs), including BHS...
April 5, 2024: Drug and Alcohol Dependence
#40
REVIEW
Yun Han Chen, Anastasios Xenitidis, Paul Hoffman, Leslie Matthews, Swathi G Padmanabhan, Lakshmi Aravindan, Ruth Ressler, Inesh Sivam, Sahana Sivam, Chase F Gillispie, Senthilkumar Sadhasivam
INTRODUCTION: Opioids are commonly used for perioperative analgesia, yet children still suffer high rates of severe post-surgical pain and opioid-related adverse effects. Persistent and severe acute surgical pain greatly increases the child's chances of chronic surgical pain, long-term opioid use, and opioid use disorder. AREAS COVERED: Enhanced recovery after surgery (ERAS) protocols, are often inadequate in treating a child's severe surgical pain. Research suggests that 'older' and longer-acting opioids such as methadone are providing better methods to treat acute post-surgical pain...
April 16, 2024: Expert Review of Clinical Pharmacology
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