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https://www.readbyqxmd.com/read/29353292/harm-reduction-program-use-psychopathology-and-medical-severity-in-patients-with-methadone-maintenance-treatment
#1
Nieves Gudelia Martínez-Luna, Laia Rodríguez-Cintas, Abderraman Esojo, Raúl Felipe Palma-Álvarez, María Robles-Martínez, Lara Grau-López, Marta Perea, Carlos Roncero
Methadone maintenance programs (MMP) for opioid dependence treatment have been widely used due to their effective therapeutic outcomes. Harm reduction programs (HRP) are complementary programs for severe patients with high risk behaviors and when abstinence is not possible. This study aims to compare patients in MMP that use HRP (MMP-HRP) and patients in MMP who do not use HRP (MMP-NO HRP). The sample was composed of 143 patients (MMP-HRP = 42 vs. MMP-NO HRP = 101). An additional subanalysis was performed with patients under 45 years of age (n = 116; MMP-HRP = 38 vs...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29340663/monthly-buprenorphine-injection-approved-for-opioid-use-disorder
#2
Rebecca Voelker
No abstract text is available yet for this article.
January 16, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29337399/impact-of-pregnancy-on-psychoactive-substance-use-among-women-with-substance-use-disorders-recruited-in-addiction-specialized-care-centers-in-france
#3
Liselotte Pochard, Julie Dupouy, Elisabeth Frauger, Adeline Giocanti, Joëlle Micallef, Maryse Lapeyre-Mestre
Pregnancy can be a motivation for decrease in drug abusing but may also represent a period of high vulnerability for relapse.We aimed to assess psychoactive substance use among women with substance use disorders followed in addiction care centers in France. We analyzed data from women aged 15-44 years included in the 'Observation of illegal drugs and misuse of psychotropic medication survey' (OPPIDUM), an annualcross-sectional survey collecting details on psychoactive substances used. Characteristics of women included in 2005 to 2012 yearly surveys were compared depending on their pregnant or not pregnant status...
January 16, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29336871/epigenetic-regulation-of-the-kappa-opioid-receptor-gene-by-an-insertion-deletion-in-the-promoter-region
#4
Pierre-Eric Lutz, Daniel Almeida, Raoul Belzeaux, Ipek Yalcin, Gustavo Turecki
Preclinical and clinical studies have demonstrated that the kappa opioid receptor (KOR) regulates reward, hedonic tone and emotions. At therapeutic level, on-going clinical trials are assessing the potential of targeting the KOR for the management of depression, anxiety disorders and substance use disorders. However, genetic polymorphisms in the KOR gene that potentially contribute to its implication in these phenotypes have been poorly studied. Here we investigated an insertion-deletion in the promoter region of KOR (rs35566036), recently associated with alcohol addiction, in a cohort of depressed subjects who died by suicide, as well as psychiatrically healthy individuals...
January 11, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29334513/opioid-use-disorders-attributed-to-tramadol-among-egyptian-university-students
#5
Medhat M Bassiony, Mohamed Abdelghani, Ghada M Salah El-Deen, Mervat S Hassan, Hayam El-Gohari, Usama M Youssef
BACKGROUND: Tramadol use is an overwhelming problem in Egypt with tremendous medical and social consequences especially among youth. Use liability among Egyptian university students is underevaluated. This study aimed to estimate the prevalence and associated correlates of tramadol use among students from Zagazig University, Egypt. METHODS: A cross-sectional study included a total of 1135 undergraduate students, from 10 colleges in Zagazig University. Participants were randomly selected and assessed for tramadol use using The Drug Use Disorders Identification Test (DUDIT) and The Drug Use Disorders Identification Test-Extended (DUDIT-E)...
January 12, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29333954/prevalence-diagnosis-and-treatment-rates-of-mood-disorders-among-opioid-users-under-criminal-justice-supervision
#6
Mary Mbaba, Shan-Estelle Brown, Alese Wooditch, Marissa Kiss, Amy Murphy, Suneeta Kumari, Faye Taxman, Frederick Altice, William B Lawson, Sandra A Springer
BACKGROUND: Individuals involved in the criminal justice system have disproportionately high rates of psychiatric disorders when compared to the general U.S. POPULATION: If left untreated, the likelihood of subsequent arrest increases and risk for adverse health consequences is great, particularly among opioid users. OBJECTIVES: To explore the prevalence, characteristics, and treatment of mood disorders among justice involved opioid-dependent populations...
January 15, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29333890/cigarette-smoking-and-quit-attempts-among-latinos-in-substance-use-disorder-treatment
#7
Anna Pagano, Noah Gubner, Thao Le, Joseph Guydish
BACKGROUND: Differences in tobacco use behaviors have been identified between Latinos and non-Latino whites in the general US population. Little is known about cigarette smoking and quitting behaviors of Latinos in treatment for substance use disorders (SUDs), who represent two major tobacco-vulnerable groups. OBJECTIVES: To compare, in a national sample of persons enrolled in SUD treatment, demographic, drug use, and smoking and quitting prevalence and behaviors between Latinos and non-Latino whites...
January 15, 2018: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29329750/women-and-the-experience-of-pain-and-opioid-use-disorder-a-literature-based-commentary
#8
Andrew L Koons, Marna Rayl Greenberg, Robert D Cannon, Gillian A Beauchamp
It is generally understood that pain experience and opioid abuse have relied on male-dominated models. However, sex and gender play a role in both pain experience and opioid use disorder. Using the previously validated Texas Tech University Health Sciences Center Sex and Gender Specific Health PubMed Advanced Search Tool, the authors used pertinent literature to develop this literature-based commentary on sex and gender differences in pain experience and opioid use disorder. Women report their experience of pain more frequently, have increased rates of diagnoses related to pain, have increased pain sensitivity, and have a variable response to pain and analgesia...
January 9, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29327358/opioid-medication-use-in-patients-with-gastrointestinal-diagnoses-vs-unexplained-gastrointestinal-symptoms-in-the-us-veterans-health-administration
#9
G S Sayuk, N Kanuri, C P Gyawali, B M Gott, B D Nix, R A Rosenheck
BACKGROUND: While opioid prescriptions have increased alarmingly in the United States (US), their use for unexplained chronic gastrointestinal (GI) pain (eg, irritable bowel syndrome) carries an especially high risk for adverse effects and questionable benefit. AIM: To compare opioid use among US veterans with structural GI diagnoses (SGID) and those with unexplained GI symptoms or functional GI diagnoses (FGID), a group for whom opioids have no accepted role. METHODS: Veterans Health Administration (VHA) administrative data from fiscal year 2012 were used to identify veterans with diagnostic codes recorded for SGID and FGID...
January 12, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29326869/prenatal-methadone-exposure-is-associated-with-altered-neonatal-brain-development
#10
Victoria J Monnelly, Devasuda Anblagan, Alan Quigley, Manuel Blesa Cabez, E Sarah Cooper, Helen Mactier, Scott I Semple, Mark E Bastin, James P Boardman
Methadone is used for medication-assisted treatment of heroin addiction during pregnancy. The neurodevelopmental outcome of children with prenatal methadone exposure can be sub-optimal. We tested the hypothesis that brain development is altered among newborn infants whose mothers were prescribed methadone. 20 methadone-exposed neonates born after 37 weeks' postmenstrual age (PMA) and 20 non-exposed controls underwent diffusion MRI at mean PMA of 39+ 2 and 41+ 1 weeks, respectively. An age-optimized Tract-based Spatial Statistics (TBSS) pipeline was used to perform voxel-wise statistical comparison of fractional anisotropy (FA) data between exposed and non-exposed neonates...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29324188/-i-m-doing-the-best-that-i-can-for-her-infant-feeding-decisions-of-mothers-receiving-medication-assisted-treatment-for-an-opioid-use-disorder
#11
Kelly S McGlothen, Lisa M Cleveland, Sara L Gill
BACKGROUND: Several professional health organizations have made statements endorsing the safety of breastfeeding for women taking medication-assisted treatment for an opioid use disorder. Yet, breastfeeding initiation rates for this population are approximately 50% lower than the general United States' population. Furthermore, little is known about what influences the infant-feeding decisions of these women. Research aim: This study aimed to describe what influences the infant-feeding decisions of women taking medication-assisted treatment for an opioid use disorder...
December 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29320915/healthcare-utilization-and-costs-associated-with-treatment-for-opioid-dependence
#12
Ankit Shah, Margaret Duncan, Nipun Atreja, Kei Sing Tai, Mugdha Gore
OBJECTIVE: Opioid use disorder (OUD) can be managed with medication assisted therapy (MAT) (methadone [MET], buprenorphine [BUP], or extended-release naltrexone [XR-NTX]) or counseling alone (non-pharmacological therapy [NPT]). The objective of this study was to evaluate healthcare resource utilization and costs associated with XR-NTX compared with alternative treatments for opioid dependence. METHODS: Adults with a diagnosis of opioid dependence who initiated treatment with XR-NTX, BUP, MET, or NPT between January 1, 2011 and December 31, 2014 were identified in the Truven Health MarketScan Commercial administrative claims database...
January 10, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29320768/attention-deficit-hyperactivity-disorder-symptoms-are-common-in-patients-in-opioid-maintenance-treatment
#13
Kristine Fiksdal Abel, Edle Ravndal, Thomas Clausen, Jørgen G Bramness
INTRODUCTION AND AIMS: Knowledge of attention deficit hyperactivity disorder (ADHD) symptoms among patients in opioid maintenance treatment (OMT) is important for treatment optimization and yet limited. We investigated the prevalence of ADHD symptoms, and factors associated with high ADHD symptom burden in a group of Norwegian OMT patients. METHODS: We interviewed individuals entering OMT across Norway in 2 steps between 2012 and 2016. ADHD symptoms were measured by the Adult ADHD Self-Report Scale (ASRS; n = 175)...
January 10, 2018: European Addiction Research
https://www.readbyqxmd.com/read/29317008/patients-with-advanced-cancer-and-depression-report-a-significantly-higher-symptom-burden-than-non-depressed-patients
#14
Kjersti Støen Grotmol, Hanne C Lie, Jon Håvard Loge, Nina Aass, Dagny Faksvåg Haugen, Patrick C Stone, Stein Kaasa, Marianne Jensen Hjermstad
OBJECTIVE: Clinical observations indicate that patients with advanced cancer and depression report higher symptom burden than nondepressed patients. This is rarely examined empirically. Study aim was to investigate the association between self-reported depression disorder (DD) and symptoms in patients with advanced cancer controlled for prognostic factors. METHOD: The sample included 935 patients, mean age 62, 52% males, from an international multicentre observational study (European Palliative Care Research Collaborative - Computerised Symptom Assessment and Classification of Pain, Depression and Physical Function)...
January 10, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29314075/alcohol-and-opioid-use-co-use-and-chronic-pain-in-the-context-of-the-opioid-epidemic-a-critical-review
#15
Katie Witkiewitz, Kevin E Vowles
The dramatic increase in opioid misuse, opioid use disorder (OUD), and opioid-related overdose deaths in the United States has led to public outcry, policy statements, and funding initiatives. Meanwhile, alcohol misuse and alcohol use disorder is a highly prevalent public health problem associated with considerable individual and societal costs. This paper provides a critical review of alcohol and opioid misuse, including issues of prevalence, morbidity, and societal costs. We also review research on interactions between alcohol and opioid use, the influence of opioids and alcohol on alcohol use disorder (AUD) and OUD treatment outcomes, respectively, the role of pain in the co-use of alcohol and opioids, and treatment of comorbid OUD and AUD...
January 4, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29311182/interdisciplinary-management-of-opioid-use-disorder-in-primary-care
#16
Rebecca E Cantone, Joan Fleishman, Brian Garvey, Nicholas Gideonse
No abstract text is available yet for this article.
January 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29305727/using-population-based-hospitalization-data-to-monitor-increases-in-conditions-causing-morbidity-among-persons-who-inject-drugs
#17
Melissa G Collier, Mona Doshani, Alice Asher
Epidemics of opioid use and injection drug use (IDU) are associated with an increase in HIV and viral hepatitis infections and overdose deaths in the United States. Persons who inject drugs (PWID) are also at risk for serious infections caused by skin organisms introduced via IDU. We examined National Inpatient Sample hospital discharge data to determine trends in three serious infectious disease-associated conditions that primarily affect PWID in addition to HIV and viral hepatitis: infective endocarditis (IE), central nervous system (CNS) abscesses, and osteomyelitis...
January 5, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29304922/the-appropriate-use-of-opioids-in-the-treatment-of-refractory-restless-legs-syndrome
#18
Michael H Silber, Philip M Becker, Mark J Buchfuhrer, Christopher J Earley, William G Ondo, Arthur S Walters, John W Winkelman
Restless legs syndrome (RLS) is a distinct disorder, differing from chronic pain in many ways. Refractory RLS is characterized by unresponsiveness to dopamine agonists or alpha-2-delta ligands due to inadequate efficacy, augmentation, or adverse effects. This may result in severely impaired quality of life, profound insomnia, and suicidal depression. Opioid therapy is a mainstay in the management of these patients. This article summarizes the basic science and clinical evidence in support of their use, including the positive result of a large controlled multicenter study of 306 subjects, and outlines an approach to their use in clinical practice...
January 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29303399/perceived-self-control-is-related-to-mental-distress-in-patients-entering-substance-use-disorder-treatment
#19
Kristine Fiksdal Abel, Ingeborg Skjærvø, Edle Ravndal, Thomas Clausen, Jørgen G Bramness
BACKGROUND: Levels of mental distress are high in patients with substance use disorders (SUD) and investigation of correlates may broaden our understanding of this comorbidity. OBJECTIVES: We investigated self-reported symptoms of mental distress among individuals entering either outpatient opioid maintenance treatment (OMT) or other inpatient SUD treatment and related factors, with a particular focus on perceived self-control. METHODS: A cross-sectional study including substance users (n = 548; mean age 34 years; 27% women) entering treatment at 21 different treatment-centers across Norway, interviewed between December 2012 and April 2015...
January 5, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29303393/high-risk-prescribing-to-medicaid-enrollees-receiving-opioid-analgesics-individual-and-county-level-factors
#20
Sara E Heins, Mark J Sorbero, Christopher M Jones, Andrew W Dick, Bradley D Stein
BACKGROUND: Prescription opioid overdoses have increased dramatically in recent years, with the highest rates among Medicaid enrollees. High-risk prescribing includes practices associated with overdoses and a range of additional opioid-related problems. OBJECTIVES: To identify individual- and county-level factors associated with high-risk prescribing among Medicaid enrollees receiving opioids. METHODS: In a four-states, cross-sectional claims data study, Medicaid enrollees 18-64 years old with a new opioid analgesic treatment episode 2007-2009 were identified...
January 5, 2018: Substance Use & Misuse
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