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Neuro plasticity

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https://www.readbyqxmd.com/read/27909400/the-demise-of-the-synapse-as-the-locus-of-memory-a-looming-paradigm-shift
#1
Patrick C Trettenbrein
Synaptic plasticity is widely considered to be the neurobiological basis of learning and memory by neuroscientists and researchers in adjacent fields, though diverging opinions are increasingly being recognized. From the perspective of what we might call "classical cognitive science" it has always been understood that the mind/brain is to be considered a computational-representational system. Proponents of the information-processing approach to cognitive science have long been critical of connectionist or network approaches to (neuro-)cognitive architecture, pointing to the shortcomings of the associative psychology that underlies Hebbian learning as well as to the fact that synapses are practically unfit to implement symbols...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/27894901/bilingualism-yields-language-specific-plasticity-in-left-hemisphere-s-circuitry-for-learning-to-read-in-young-children
#2
K K Jasińska, M S Berens, I Kovelman, L A Petitto
How does bilingual exposure impact children's neural circuitry for learning to read? Theories of bilingualism suggests that exposure to two languages may yield a functional and neuroanatomical adaptation to support the learning of two languages (Klein et al., 2014). To test the hypothesis that this neural adaptation may vary as a function of structural and orthographic characteristics of bilinguals' two languages, we compared Spanish-English and French-English bilingual children, and English monolingual children, using functional Near Infrared Spectroscopy neuroimaging (fNIRS, ages 6-10, N = 26)...
November 25, 2016: Neuropsychologia
https://www.readbyqxmd.com/read/27844057/combined-treatment-with-environmental-enrichment-and-epigallocatechin-3-gallate-ameliorates-learning-deficits-and-hippocampal-alterations-in-a-mouse-model-of-down-syndrome
#3
Silvina Catuara-Solarz, Jose Espinosa-Carrasco, Ionas Erb, Klaus Langohr, Juan Ramon Gonzalez, Cedric Notredame, Mara Dierssen
Intellectual disability in Down syndrome (DS) is accompanied by altered neuro-architecture, deficient synaptic plasticity, and excitation-inhibition imbalance in critical brain regions for learning and memory. Recently, we have demonstrated beneficial effects of a combined treatment with green tea extract containing (-)-epigallocatechin-3-gallate (EGCG) and cognitive stimulation in young adult DS individuals. Although we could reproduce the cognitive-enhancing effects in mouse models, the underlying mechanisms of these beneficial effects are unknown...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27825385/neurogenomics-and-the-role-of-a-large-mutational-target-on-rapid-behavioral-change
#4
Craig E Stanley, Rob J Kulathinal
BACKGROUND: Behavior, while complex and dynamic, is among the most diverse, derived, and rapidly evolving traits in animals. The highly labile nature of heritable behavioral change is observed in such evolutionary phenomena as the emergence of converged behaviors in domesticated animals, the rapid evolution of preferences, and the routine development of ethological isolation between diverging populations and species. In fact, it is believed that nervous system development and its potential to evolve a seemingly infinite array of behavioral innovations played a major role in the successful diversification of metazoans, including our own human lineage...
November 8, 2016: Biology Direct
https://www.readbyqxmd.com/read/27817916/orbital-periorbital-plexiform-neurofibromas-in-children-with-neurofibromatosis-type-1-multidisciplinary-recommendations-for-care
#5
Robert A Avery, James A Katowitz, Michael J Fisher, Gena Heidary, Eva Dombi, Roger J Packer, Brigitte C Widemann
TOPIC: Children and adults with neurofibromatosis type 1 (NF1), a common autosomal dominant condition, manifest a variety of ophthalmologic conditions. Plexiform neurofibromas (PNs) involving the eyelid, orbit, periorbital, and facial structures (orbital-periorbital plexiform neurofibroma [OPPN]) can result in significant visual loss in children. Equally important, OPPNs can cause significant alteration in physical appearance secondary to proptosis, ptosis, and facial disfigurement, leading to social embarrassment and decreased self-esteem...
November 3, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27806074/a-novel-robot-system-integrating-biological-and-mechanical-intelligence-based-on-dissociated-neural-network-controlled-closed-loop-environment
#6
Yongcheng Li, Rong Sun, Yuechao Wang, Hongyi Li, Xiongfei Zheng
We propose the architecture of a novel robot system merging biological and artificial intelligence based on a neural controller connected to an external agent. We initially built a framework that connected the dissociated neural network to a mobile robot system to implement a realistic vehicle. The mobile robot system characterized by a camera and two-wheeled robot was designed to execute the target-searching task. We modified a software architecture and developed a home-made stimulation generator to build a bi-directional connection between the biological and the artificial components via simple binomial coding/decoding schemes...
2016: PloS One
https://www.readbyqxmd.com/read/27782019/whatsapp-in-clinical-practice-a-literature-review
#7
Maurice Mars, Richard E Scott
: Several spontaneous telemedicine services using WhatsApp Messenger have started in South Africa raising issues of confidentiality, data security and storage, record keeping and reporting. This study reviewed the literature on WhatsApp in clinical practice, to determine how it is used, and users' satisfaction. METHODS: Pubmed, Scopus, Science Direct and IEE Expert databases were searched using the search term WhatsApp and Google Scholar using the terms WhatsApp Telemedicine and WhatsApp mHealth...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27757131/decreased-plasma-bdnf-levels-of-patients-with-somatization-disorder
#8
Nam-In Kang, Jong-Il Park, Yong-Ku Kim, Jong-Chul Yang
OBJECTIVE: Brain-derived neurotrophic factor (BDNF), one of the most abundant and important neurotrophins, is known to be involved in the development, survival, maintenance, and plasticity of neurons in the nervous system. Some studies have suggested that BDNF may play a role in the pathophysiology of several psychiatric illnesses such as depression and schizophrenia. Similarly, it is likely that the alteration of BDNF may be associated with the neuro-modulation that contributes to the development of somatization disorder...
September 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27676998/effect-of-visual-feedback-on-speech-recovery-and-language-plasticity-in-patients-with-post-stroke-non-fluent-aphasia-functional-mri-assessment
#9
Monica Baciu, Audrey Acher, Louise Kauffmann, Emilie Cousin, Claire Boilley, Thomas Hueber, Pierre Badin, Pascal Perrier, Diandra Fabre, Assia Jaillard, Olivier Detante, Dominique Perennou
OBJECTIVE: To assess the efficiency of Visual Feedback (VF) on language recovery and plasticity in three chronic non-fluent aphasic patients. VF is based on language-action interaction, thus, language skills are improved by rehabilitation strategies based on execution and observation of motor actions. VF is an ultrasound system coupled with video images, allowing patients to 'see their own lips and tongue at work' during speech and improve their awareness of their lingual and labial movements and their ability to coordinate and combine phonemes and syllables...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27669639/activation-of-npff2-receptor-stimulates-neurite-outgrowth-in-neuro-2a-cells-through-activation-of-erk-signaling-pathway
#10
Hong-Ping Yu, Nan Zhang, Ting Zhang, Zi-Long Wang, Ning Li, Hong-Hai Tang, Run Zhang, Meng-Na Zhang, Biao Xu, Quan Fang, Rui Wang
Neurite outgrowth is an important process in neural regeneration and plasticity, especially after neural injury, and recent evidence indicates that several Gαi/o protein-coupled receptors play an important role in neurite outgrowth. The neuropeptide (NP)FF system contains two Gαi/o protein-coupled receptors, NPFF1 and NPFF2 receptors, which are mainly distributed in the central nervous system. The aim of the present study was to determine whether the NPFF system is involved in neurite outgrowth in Neuro 2A cells...
December 2016: Peptides
https://www.readbyqxmd.com/read/27626967/an-online-structural-plasticity-rule-for-generating-better-reservoirs
#11
Subhrajit Roy, Arindam Basu
In this letter, we propose a novel neuro-inspired low-resolution online unsupervised learning rule to train the reservoir or liquid of liquid state machines. The liquid is a sparsely interconnected huge recurrent network of spiking neurons. The proposed learning rule is inspired from structural plasticity and trains the liquid through formating and eliminating synaptic connections. Hence, the learning involves rewiring of the reservoir connections similar to structural plasticity observed in biological neural networks...
September 14, 2016: Neural Computation
https://www.readbyqxmd.com/read/27622105/botulinum-toxin-a-dose-dependent-effect-on-reepithelialization-and-angiogenesis
#12
Alfred Gugerell, Johanna Kober, Melanie Schmid, Elisabeth Buchberger, Lars-Peter Kamolz, Maike Keck
BACKGROUND: Botulinum (neuro)toxin A (BoNT) is widely used in the field of plastic and reconstructive surgery. Among treatment of pain, hyperhidrosis, or aesthetic purposes, it is also used to enhance wound healing and prevent excessive scar formation. Some clinical data already exist, but only little is known on a cellular level. The aim of this study was to evaluate the effect of BoNT on cells essential for wound healing in vitro. Therefore, primary human keratinocytes and endothelial cells were treated with different concentrations of BoNT and tested on proliferation, migration, and angiogenic behavior...
August 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27551273/near-infrared-spectroscopy-electroencephalography-based-brain-state-dependent-electrotherapy-a-computational-approach-based-on-excitation-inhibition-balance-hypothesis
#13
Snigdha Dagar, Shubhajit Roy Chowdhury, Raju Surampudi Bapi, Anirban Dutta, Dipanjan Roy
Stroke is the leading cause of severe chronic disability and the second cause of death worldwide with 15 million new cases and 50 million stroke survivors. The poststroke chronic disability may be ameliorated with early neuro rehabilitation where non-invasive brain stimulation (NIBS) techniques can be used as an adjuvant treatment to hasten the effects. However, the heterogeneity in the lesioned brain will require individualized NIBS intervention where innovative neuroimaging technologies of portable electroencephalography (EEG) and functional-near-infrared spectroscopy (fNIRS) can be leveraged for Brain State Dependent Electrotherapy (BSDE)...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27465276/coupling-of-transient-near-infrared-photonic-with-magnetic-nanoparticle-for-potential-dissipation-free-biomedical-application-in-brain
#14
Vidya Sagar, V S R Atluri, A Tomitaka, P Shah, A Nagasetti, S Pilakka-Kanthikeel, N El-Hage, A McGoron, Y Takemura, M Nair
Combined treatment strategies based on magnetic nanoparticles (MNPs) with near infrared ray (NIR) biophotonic possess tremendous potential for non-invasive therapeutic approach. Nonetheless, investigations in this direction have been limited to peripheral body region and little is known about the potential biomedical application of this approach for brain. Here we report that transient NIR exposure is dissipation-free and has no adverse effect on the viability and plasticity of major brain cells in the presence or absence superparamagnetic nanoparticles...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27455898/all-memristive-neuromorphic-computing-with-level-tuned-neurons
#15
Angeliki Pantazi, Stanisław Woźniak, Tomas Tuma, Evangelos Eleftheriou
In the new era of cognitive computing, systems will be able to learn and interact with the environment in ways that will drastically enhance the capabilities of current processors, especially in extracting knowledge from vast amount of data obtained from many sources. Brain-inspired neuromorphic computing systems increasingly attract research interest as an alternative to the classical von Neumann processor architecture, mainly because of the coexistence of memory and processing units. In these systems, the basic components are neurons interconnected by synapses...
September 2, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27427471/spred-2-expression-is-associated-with-neural-repair-of-injured-adult-zebrafish-brain
#16
Fei Tieng Lim, Satoshi Ogawa, Ishwar S Parhar
Sprouty-related protein-2 (Spred-2) is a negative regulator of extracellular signal-regulated kinases (ERK) pathway, which is important for cell proliferation, neuronal differentiation, plasticity and survival. Nevertheless, its general molecular characteristics such as gene expression patterns and potential role in neural repair in the brain remain unknown. Thus, this study aimed to characterize the expression of spred-2 in the zebrafish brain. Digoxigenin-in situ hybridization showed spred-2 mRNA-expressing cells were mainly seen in the proliferative zones such as the olfactory bulb, telencephalon, optic tectum, cerebellum, and the dorsal and ventral hypothalamus, and most of which were neuronal cells...
July 14, 2016: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27247547/-18-f-fet-and-18-f-fch-uptake-in-human-glioblastoma-t98g-cell-lines
#17
Marco Giovanni Persico, Federica Eleonora Buroni, Francesca Pasi, Lorenzo Lodola, Carlo Aprile, Rosanna Nano, Marina Hodolic
BACKGROUND: Despite complex treatment of surgery, radiotherapy and chemotherapy, high grade gliomas often recur. Differentiation between post-treatment changes and recurrence is difficult. (18)F-methyl-choline ((18)F-FCH) is frequently used in staging and detection of recurrent prostate cancer disease as well as some brain tumours; however accumulation in inflammatory tissue limits its specificity. The (18)F-ethyl-tyrosine ((18)F-FET) shows a specific uptake in malignant cells, resulting from increased expression of amino acid transporters or diffusing through the disrupted blood-brain barrier...
June 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27246565/hypothesizing-music-intervention-enhances-brain-functional-connectivity-involving-dopaminergic-recruitment-common-neuro-correlates-to-abusable-drugs
#18
Kenneth Blum, Thomas Simpatico, Marcelo Febo, Chris Rodriquez, Kristina Dushaj, Mona Li, Eric R Braverman, Zsolt Demetrovics, Marlene Oscar-Berman, Rajendra D Badgaiyan
The goal of this review is to explore the clinical significance of music listening on neuroplasticity and dopaminergic activation by understanding the role of music therapy in addictive behavior treatment. fMRI data has shown that music listening intensely modifies mesolimbic structural changes responsible for reward processing (e.g., nucleus accumbens [NAc]) and may control the emotional stimuli's effect on autonomic and physiological responses (e.g., hypothalamus). Music listening has been proven to induce the endorphinergic response blocked by naloxone, a common opioid antagonist...
May 31, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27226636/structural-and-functional-characterization-of-programmed-ribosomal-frameshift-signals-in-west-nile-virus-strains-reveals-high-structural-plasticity-among-cis-acting-rna-elements
#19
Christine Moomau, Sharmishtha Musalgaonkar, Yousuf A Khan, John E Jones, Jonathan D Dinman
West Nile virus (WNV) is a prototypical emerging virus for which no effective therapeutics currently exist. WNV uses programmed -1 ribosomal frameshifting (-1 PRF) to synthesize the NS1' protein, a C terminally extended version of its non-structural protein 1, the expression of which enhances neuro-invasiveness and viral RNA abundance. Here, the NS1' frameshift signals derived from four WNV strains were investigated to better understand -1 PRF in this quasispecies. Sequences previously predicted to promote -1 PRF strongly promote this activity, but frameshifting was significantly more efficient upon inclusion of additional 3' sequence information...
July 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27127458/deconstructing-brain-derived-neurotrophic-factor-actions-in-adult-brain-circuits-to-bridge-an-existing-informational-gap-in-neuro-cell-biology
#20
REVIEW
Heather Bowling, Aditi Bhattacharya, Eric Klann, Moses V Chao
Brain-derived neurotrophic factor (BDNF) plays an important role in neurodevelopment, synaptic plasticity, learning and memory, and in preventing neurodegeneration. Despite decades of investigations into downstream signaling cascades and changes in cellular processes, the mechanisms of how BDNF reshapes circuits in vivo remain unclear. This informational gap partly arises from the fact that the bulk of studies into the molecular actions of BDNF have been performed in dissociated neuronal cultures, while the majority of studies on synaptic plasticity, learning and memory were performed in acute brain slices or in vivo...
March 2016: Neural Regeneration Research
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