Read by QxMD icon Read

Neuro plasticity

Nam-In Kang, Jong-Il Park, Yong-Ku Kim, Jong-Chul Yang
OBJECTIVE: Brain-derived neurotrophic factor (BDNF), one of the most abundant and important neurotrophins, is known to be involved in the development, survival, maintenance, and plasticity of neurons in the nervous system. Some studies have suggested that BDNF may play a role in the pathophysiology of several psychiatric illnesses such as depression and schizophrenia. Similarly, it is likely that the alteration of BDNF may be associated with the neuro-modulation that contributes to the development of somatization disorder...
September 2016: Psychiatry Investigation
Monica Baciu, Audrey Acher, Louise Kauffmann, Emilie Cousin, Claire Boilley, Thomas Hueber, Pierre Badin, Pascal Perrier, Diandra Fabre, Assia Jaillard, Olivier Detante, Dominique Perennou
OBJECTIVE: To assess the efficiency of Visual Feedback (VF) on language recovery and plasticity in three chronic non-fluent aphasic patients. VF is based on language-action interaction, thus, language skills are improved by rehabilitation strategies based on execution and observation of motor actions. VF is an ultrasound system coupled with video images, allowing patients to 'see their own lips and tongue at work' during speech and improve their awareness of their lingual and labial movements and their ability to coordinate and combine phonemes and syllables...
September 2016: Annals of Physical and Rehabilitation Medicine
Hong-Ping Yu, Nan Zhang, Ting Zhang, Zi-Long Wang, Ning Li, Hong-Hai Tang, Run Zhang, Meng-Na Zhang, Biao Xu, Quan Fang, Rui Wang
Neurite outgrowth is an important process in neural regeneration and plasticity, especially after neural injury, and recent evidence indicates that several Gαi/o protein-coupled receptors play an important role in neurite outgrowth. The neuropeptide (NP)FF system contains two Gαi/o protein-coupled receptors, NPFF1 and NPFF2 receptors, which are mainly distributed in the central nervous system. The aim of the present study was to determine whether the NPFF system is involved in neurite outgrowth in Neuro 2A cells...
September 23, 2016: Peptides
Subhrajit Roy, Arindam Basu
In this letter, we propose a novel neuro-inspired low-resolution online unsupervised learning rule to train the reservoir or liquid of liquid state machines. The liquid is a sparsely interconnected huge recurrent network of spiking neurons. The proposed learning rule is inspired from structural plasticity and trains the liquid through formating and eliminating synaptic connections. Hence, the learning involves rewiring of the reservoir connections similar to structural plasticity observed in biological neural networks...
September 14, 2016: Neural Computation
Alfred Gugerell, Johanna Kober, Melanie Schmid, Elisabeth Buchberger, Lars-Peter Kamolz, Maike Keck
BACKGROUND: Botulinum (neuro)toxin A (BoNT) is widely used in the field of plastic and reconstructive surgery. Among treatment of pain, hyperhidrosis, or aesthetic purposes, it is also used to enhance wound healing and prevent excessive scar formation. Some clinical data already exist, but only little is known on a cellular level. The aim of this study was to evaluate the effect of BoNT on cells essential for wound healing in vitro. Therefore, primary human keratinocytes and endothelial cells were treated with different concentrations of BoNT and tested on proliferation, migration, and angiogenic behavior...
August 2016: Plastic and Reconstructive Surgery. Global Open
Snigdha Dagar, Shubhajit Roy Chowdhury, Raju Surampudi Bapi, Anirban Dutta, Dipanjan Roy
Stroke is the leading cause of severe chronic disability and the second cause of death worldwide with 15 million new cases and 50 million stroke survivors. The poststroke chronic disability may be ameliorated with early neuro rehabilitation where non-invasive brain stimulation (NIBS) techniques can be used as an adjuvant treatment to hasten the effects. However, the heterogeneity in the lesioned brain will require individualized NIBS intervention where innovative neuroimaging technologies of portable electroencephalography (EEG) and functional-near-infrared spectroscopy (fNIRS) can be leveraged for Brain State Dependent Electrotherapy (BSDE)...
2016: Frontiers in Neurology
Vidya Sagar, V S R Atluri, A Tomitaka, P Shah, A Nagasetti, S Pilakka-Kanthikeel, N El-Hage, A McGoron, Y Takemura, M Nair
Combined treatment strategies based on magnetic nanoparticles (MNPs) with near infrared ray (NIR) biophotonic possess tremendous potential for non-invasive therapeutic approach. Nonetheless, investigations in this direction have been limited to peripheral body region and little is known about the potential biomedical application of this approach for brain. Here we report that transient NIR exposure is dissipation-free and has no adverse effect on the viability and plasticity of major brain cells in the presence or absence superparamagnetic nanoparticles...
2016: Scientific Reports
Angeliki Pantazi, Stanisław Woźniak, Tomas Tuma, Evangelos Eleftheriou
In the new era of cognitive computing, systems will be able to learn and interact with the environment in ways that will drastically enhance the capabilities of current processors, especially in extracting knowledge from vast amount of data obtained from many sources. Brain-inspired neuromorphic computing systems increasingly attract research interest as an alternative to the classical von Neumann processor architecture, mainly because of the coexistence of memory and processing units. In these systems, the basic components are neurons interconnected by synapses...
September 2, 2016: Nanotechnology
Fei Tieng Lim, Satoshi Ogawa, Ishwar S Parhar
Sprouty-related protein-2 (Spred-2) is a negative regulator of extracellular signal-regulated kinases (ERK) pathway, which is important for cell proliferation, neuronal differentiation, plasticity and survival. Nevertheless, its general molecular characteristics such as gene expression patterns and potential role in neural repair in the brain remain unknown. Thus, this study aimed to characterize the expression of spred-2 in the zebrafish brain. Digoxigenin-in situ hybridization showed spred-2 mRNA-expressing cells were mainly seen in the proliferative zones such as the olfactory bulb, telencephalon, optic tectum, cerebellum, and the dorsal and ventral hypothalamus, and most of which were neuronal cells...
July 14, 2016: Journal of Chemical Neuroanatomy
Marco Giovanni Persico, Federica Eleonora Buroni, Francesca Pasi, Lorenzo Lodola, Carlo Aprile, Rosanna Nano, Marina Hodolic
BACKGROUND: Despite complex treatment of surgery, radiotherapy and chemotherapy, high grade gliomas often recur. Differentiation between post-treatment changes and recurrence is difficult. (18)F-methyl-choline ((18)F-FCH) is frequently used in staging and detection of recurrent prostate cancer disease as well as some brain tumours; however accumulation in inflammatory tissue limits its specificity. The (18)F-ethyl-tyrosine ((18)F-FET) shows a specific uptake in malignant cells, resulting from increased expression of amino acid transporters or diffusing through the disrupted blood-brain barrier...
June 1, 2016: Radiology and Oncology
Kenneth Blum, Thomas Simpatico, Marcelo Febo, Chris Rodriquez, Kristina Dushaj, Mona Li, Eric R Braverman, Zsolt Demetrovics, Marlene Oscar-Berman, Rajendra D Badgaiyan
The goal of this review is to explore the clinical significance of music listening on neuroplasticity and dopaminergic activation by understanding the role of music therapy in addictive behavior treatment. fMRI data has shown that music listening intensely modifies mesolimbic structural changes responsible for reward processing (e.g., nucleus accumbens [NAc]) and may control the emotional stimuli's effect on autonomic and physiological responses (e.g., hypothalamus). Music listening has been proven to induce the endorphinergic response blocked by naloxone, a common opioid antagonist...
May 31, 2016: Molecular Neurobiology
Christine Moomau, Sharmishtha Musalgaonkar, Yousuf A Khan, John E Jones, Jonathan D Dinman
West Nile virus (WNV) is a prototypical emerging virus for which no effective therapeutics currently exist. WNV uses programmed -1 ribosomal frameshifting (-1 PRF) to synthesize the NS1' protein, a C terminally extended version of its non-structural protein 1, the expression of which enhances neuro-invasiveness and viral RNA abundance. Here, the NS1' frameshift signals derived from four WNV strains were investigated to better understand -1 PRF in this quasispecies. Sequences previously predicted to promote -1 PRF strongly promote this activity, but frameshifting was significantly more efficient upon inclusion of additional 3' sequence information...
July 22, 2016: Journal of Biological Chemistry
Heather Bowling, Aditi Bhattacharya, Eric Klann, Moses V Chao
Brain-derived neurotrophic factor (BDNF) plays an important role in neurodevelopment, synaptic plasticity, learning and memory, and in preventing neurodegeneration. Despite decades of investigations into downstream signaling cascades and changes in cellular processes, the mechanisms of how BDNF reshapes circuits in vivo remain unclear. This informational gap partly arises from the fact that the bulk of studies into the molecular actions of BDNF have been performed in dissociated neuronal cultures, while the majority of studies on synaptic plasticity, learning and memory were performed in acute brain slices or in vivo...
March 2016: Neural Regeneration Research
Michel Lacour, Christoph Helmchen, Pierre-Paul Vidal
Why vestibular compensation (VC) after an acute unilateral vestibular loss is the neuro-otologist's best friend is the question at the heart of this paper. The different plasticity mechanisms underlying VC are first reviewed, and the authors present thereafter the dual concept of vestibulo-centric versus distributed learning processes to explain the compensation of deficits resulting from the static versus dynamic vestibular imbalance. The main challenges for the plastic events occurring in the vestibular nuclei (VN) during a post-lesion critical period are neural protection, structural reorganization and rebalance of VN activity on both sides...
April 2016: Journal of Neurology
Franca Rosa Guerini, Elisabetta Farina, Andrea Saul Costa, Francesca Baglio, Francesca Lea Saibene, Nicolò Margaritella, Elena Calabrese, Milena Zanzottera, Elisabetta Bolognesi, Raffaello Nemni, Mario Clerici
BACKGROUND: Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Rate of decline and functional restoration in AD greatly depend on the capacity for neural plasticity within residual neural tissues; this is at least partially influenced by polymorphisms in genes that determine neural plasticity, including Apolipoprotein E4 (ApoE4) and synaptosomal-associated protein of 25 kDa (SNAP-25). OBJECTIVE: We investigated whether correlations could be detected between polymorphisms of ApoE4 and SNAP-25 and the outcome of a multidimensional rehabilitative approach, based on cognitive stimulation, behavioral, and functional therapy (multidimensional stimulation therapy [MST])...
October 2016: Neurorehabilitation and Neural Repair
Daniel Stam, Jennifer Fernandez
INTRODUCTION: Diffuse axonal injury is a prominent cause of disablement post-traumatic brain injury. Utilization of the rapid expansion of our current scientific knowledge base combined with greater access to neurological and assistive technology as adjuncts to providing sensorimotor experience may yield innovative new approaches to rehabilitation based upon a dynamic model of brain response following injury. CASE DESCRIPTION: A 24-year-old female who sustained a traumatic brain injury, bilateral subdural hemorrhage, subarachnoid hemorrhage and severe diffuse axonal injury secondary to a motor vehicle collision...
April 6, 2016: Disability and Rehabilitation. Assistive Technology
Sheela Vyas, Ana João Rodrigues, Joana Margarida Silva, Francois Tronche, Osborne F X Almeida, Nuno Sousa, Ioannis Sotiropoulos
Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central nervous system, ranging from the regulation of gene transcription, cellular signaling, modulation of synaptic structure, and transmission and glial function to behavior. Their actions are mediated by glucocorticoid and mineralocorticoid receptors which are nuclear receptors/transcription factors. While GCs primarily act to maintain homeostasis by inducing physiological and behavioral adaptation, prolonged exposure to stress and elevated GC levels may result in neuro- and psychopathology...
2016: Neural Plasticity
Giovanni Cirillo, Anna Maria Colangelo, Ciro De Luca, Leonilde Savarese, Maria Rosaria Barillari, Lilia Alberghina, Michele Papa
Modulation of extracellular matrix (ECM) remodeling after peripheral nerve injury (PNI) could represent a valid therapeutic strategy to prevent maladaptive synaptic plasticity in central nervous system (CNS). Inhibition of matrix metalloproteinases (MMPs) and maintaining a neurotrophic support could represent two approaches to prevent or reduce the maladaptive plastic changes in the ventral horn of spinal cord following PNI. The purpose of our study was to analyze changes in the ventral horn produced by gliopathy determined by the suffering of motor neurons following spared nerve injury (SNI) of the sciatic nerve and how the intrathecal (i...
2016: PloS One
Rachel Zhorne, Shauna Dudley-Javoroski, Richard K Shields
No abstract text is available yet for this article.
January 2016: Neural Regeneration Research
Mariska Bot, Yuri Milaneschi, Brenda W J H Penninx, Madeleine L Drent
It has been postulated that many peripheral and (neuro)biological systems are involved in psychiatric disorders such as depression. Some studies found associations of depression and antidepressant treatment with insulin-like growth factor 1 (IGF-I) - a pleiotropic hormone affecting neuronal growth, survival and plasticity - but evidence is mixed. We therefore studied whether depressive and anxiety disorders were associated with plasma IGF-I, and explored the role of antidepressant medication in this association in a large observational study...
June 2016: Psychoneuroendocrinology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"