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screening gastric cancer

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https://www.readbyqxmd.com/read/28106227/can-ngal-be-employed-as-prognostic-and-diagnostic-biomarker-in-human-cancers-a-systematic-review-of-current-evidence
#1
Laura Roli, Valentina Pecoraro, Tommaso Trenti
BACKGROUND: Some studies have reported differentially altered neutrophil gelatinase-associated lipocalin (NGAL) levels in several malignancies. We evaluated NGAL measured in plasma or urine as both prognostic and diagnostic marker for different types of human tumors. METHODS: We performed systematic electronic searches in Medline, Embase and CRDTAS. Studies were included if they evaluated NGAL as a prognostic or diagnostic marker for human cancers. The selection of the studies, screening of the full texts and data extraction were conducted independently by 2 authors...
January 16, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28105191/plasma-lncrna-gacat2-is-a-valuable-marker-for-the-screening-of-gastric-cancer
#2
Lin Tan, Yunben Yang, Yongfu Shao, Haiqiang Zhang, Junming Guo
Long non-coding RNAs (lncRNAs) are crucial in contributing to gastric tumorigenesis and development. However, the diagnostic value of the majority of lncRNAs in gastric cancer (GC) are not clear. The present study investigated the diagnostic value of gastric cancer associated transcript 2 (GACAT2), a lncRNA that is aberrantly expressed in GC tissues. A total of 343 plasma samples from 80 healthy individuals, 29 patients with gastric dysplasia (GD) and 117 paired preoperative and postoperative patients with GC were collected...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28093653/the-administrative-project-of-helicobacter-pylori-infection-screening-among-junior-high-school-students-in-an-area-of-japan-with-a-high-incidence-of-gastric-cancer
#3
Chika Kusano, Takuji Gotoda, Hideki Ishikawa, Mitsuhiko Moriyama
OBJECTIVE: Helicobacter pylori infection is a common chronic infection that is closely associated with gastric cancer, known to be decreasing worldwide. We set up an administrative project of screening examination for H. pylori infection in junior high school students in Akita Prefecture to investigate the current prevalence of H. pylori infection in childhood in an area where the incidence of gastric cancer is particularly high. SUBJECTS AND METHODS: All students in their second or third year of junior high school (13 to 15 years old) in two cities in Akita Prefecture were recruited...
January 16, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28089973/malignancies-in-patients-with-anti-rna-polymerase-iii-antibodies-and-systemic-sclerosis-analysis-of-the-eular-scleroderma-trials-and-research-cohort-and-possible-recommendations-for-screening
#4
Maria-Grazia Lazzaroni, Ilaria Cavazzana, Enrico Colombo, Rucsandra Dobrota, Jasmin Hernandez, Roger Hesselstrand, Cecilia Varju, Gabriella Nagy, Vanessa Smith, Paola Caramaschi, Valeria Riccieri, Eric Hachulla, Alexandra Balbir-Gurman, Emmanuel Chatelus, Katarzyna Romanowska-Próchnicka, Ana Carolina Araújo, Oliver Distler, Yannick Allanore, Paolo Airò
OBJECTIVE: To analyze the characteristics of anti-RNA polymerase III antibodies (anti-RNAP3)- positive patients with systemic sclerosis (SSc) in the European League Against Rheumatism Scleroderma Trials and Research group (EUSTAR) registry with a focus on the risk of cancer and the characteristics of malignancies, and the aim to provide guidelines about potential cancer screening in these patients. METHODS: (1) Analysis of the EUSTAR database: 4986 patients with information on their anti-RNAP3 status were included...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28087975/screening-and-treating-helicobacter-pylori-infection-for-gastric-cancer-prevention-on-the-population-level
#5
REVIEW
Yi-Chia Lee, Jaw-Town Lin
Helicobacter pylori infection is the major cause of gastric cancer, and removal of H. pylori infection from a population could theoretically decrease the number of cases by about 89%. However, in real-life settings, few studies have reported the effect of screening and treating this pathogen in population-based programs. This is mainly because of the lack of an adequate infrastructure for delivery of systematic screening services to asymptomatic individuals, the lack of standardization to ensure that each subject receives the correct diagnostic testing and antibiotic treatment, and limited resources...
January 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28081155/evaluation-of-bufadienolides-as-the-main-antitumor-components-in-cinobufacin-injection-for-liver-and-gastric-cancer-therapy
#6
Xiaolu Wei, Nan Si, Yuefei Zhang, Haiyu Zhao, Jian Yang, Hongjie Wang, Lianmei Wang, Linyu Han, Baolin Bian
BACKGROUND: Cinobufacin injection, also known as huachansu, is a preparation form of Cinobufacini made from Cinobufacin extract liquid. Despite that Cinobufacin injection is shown to shrink liver and gastric tumors, improving patient survival and life quality, the effective components in Cinobufacin remain elusive. In this study, we aim to screen antitumor components from Cinobufacin injection to elucidate the most effective antitumor components for treatment of liver and gastric cancers...
2017: PloS One
https://www.readbyqxmd.com/read/28079831/gastric-cancer-burden-of-last-40-years-in-north-china-hebei-province-a-population-based-study
#7
Di Liang, Suoyuan Liang, Jing Jin, Daojuan Li, Jin Shi, Yutong He
Gastric cancer (GC) is the second leading cause of cancer death in China. It is well known that Cixian in Hebei Province is one of the highest risk areas of GC in China and worldwide. This study aims to accurate assessment of GC burden and trend in high-risk area (Hebei Province) from 1973 to 2013. The authors analyzed GC data from 21 population-based cancer registries which represented 15.25% of the entire population of Hebei Province. The collected data were stratified by 5-year age groups, gender, and area...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28078605/transcriptional-regulatory-network-analysis-for-gastric-cancer-based-on-mrna-microarray
#8
Yan Wang
We aimed to screen the differential expressed genes (DEGs) and transcriptional factors (TFs) related to gastric cancer. GSE19826 microarray data downloaded from Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) and PPI network of DEGs were constructed by the Retrieval of Interacting Genes database. Pathway enrichment analysis of DEGs were performed by Gene Set Enrichment Analysis. Then, the transcriptional regulatory network was constructed based on TRANSFAC database. Finally, regulatory impact factor (RIF) of TF was calculated...
January 11, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28066960/consensus-on-the-clinical-management-screening-to-treat-and-surveillance-of-helicobacter-pylori-infection-to-improve-gastric-cancer-control-on-a-nationwide-scale
#9
Bor-Shyang Sheu, Ming-Shiang Wu, Cheng-Tang Chiu, Jing-Chuan Lo, Deng-Chyang Wu, Jyh-Ming Liou, Chun-Ying Wu, Hsiu-Chi Cheng, Yi-Chia Lee, Ping-I Hsu, Chun-Chao Chang, Wei-Lun Chang, Jaw-Town Lin
BACKGROUND: Previous international consensus statements provided general policies for the management of Helicobacter pylori infection. However, there are geographic differences in the prevalence and antimicrobial resistance of H. pylori, and in the availability of medications and endoscopy. Thus, nationwide or regional consensus statements are needed to improve control of H. pylori infection and gastric cancer. MATERIALS AND METHODS: This consensus statement for management of H...
January 8, 2017: Helicobacter
https://www.readbyqxmd.com/read/28056823/clinical-significance-of-ugt1a1-polymorphism-and-expression-of-ercc1-brca1-tyms-rrm1-tubb3-stmn1-and-top2a-in-gastric-cancer
#10
Yongkuan Cao, Guohu Zhang, Peihong Wang, Jun Zhou, Wei Gan, Yaning Song, Ling Huang, Ya Zhang, Guode Luo, Jiaqing Gong, Lin Zhang
BACKGROUND: Individualized therapeutic regimen is a recently intensively pursued approach for targeting diseases, in which the search for biomarkers was considered the first and most important. Thus, the goal of this study was to investigate whether the UGT1A1, ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A genes are underlying biomarkers for gastric cancer, which, to our knowledge, has not been performed. METHODS: Ninety-eight tissue specimens were collected from gastric cancer patients between May 2012 and March 2015...
January 5, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28053340/population-screening-and-treatment-of-helicobacter-pylori-infection
#11
REVIEW
Anthony O'Connor, Colm A O'Morain, Alexander C Ford
Helicobacter pylori is an important human pathogen, associated with a substantial burden from both malignant and non-malignant diseases. The bacterium is classed as a human carcinogen, being strongly linked with gastric cancer, the third most common cause of cancer death worldwide and is also associated with common conditions such as dyspepsia and peptic ulcer. Eradication of H. pylori reduces the incidence of gastric cancer and peptic ulcer, as well as the prevalence and costs of managing dyspepsia. Economic analyses suggest that eradication of H...
January 5, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28052004/direct-analysis-of-aberrant-glycosylation-on-haptoglobin-in-patients-with-gastric-cancer
#12
Jae-Han Kim, Sung Hyeon Lee, Sookyung Choi, Unyong Kim, In Seok Yeo, Su Hee Kim, Myung Jin Oh, Hantae Moon, Jua Lee, Seunghyup Jeong, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim, Yang Won Min, Hyuk Lee, Jun Haeng Lee, Poong-Lyul Rhee, Jae J Kim, Su Jin Lee, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Hyun Joo An, Jung Hoe Kim
Based on our previous studies, differential analysis of N-glycan expression bound on serum haptoglobin reveals the quantitative variation on gastric cancer patients. In this prospective case-control study, we explore the clinically relevant glycan markers for gastric cancer diagnosis. Serum samples were collected from patients with gastric cancer (n = 44) and healthy control (n = 44). N-glycans alteration was monitored by intact analysis of Hp using liquid chromatography-mass spectrometry followed by immunoaffinity purification with the serum samples...
December 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/28042329/genome-wide-lncrna-microarray-profiling-identifies-novel-circulating-lncrnas-for-detection-of-gastric-cancer
#13
Kecheng Zhang, Hongzhi Shi, Hongqing Xi, Xiaosong Wu, Jianxin Cui, Yunhe Gao, Wenquan Liang, Chong Hu, Yi Liu, Jiyang Li, Ning Wang, Bo Wei, Lin Chen
Long non-coding RNAs (lncRNAs) can serve as blood-based biomarkers for cancer detection. To identify novel lncRNA biomarkers for gastric cancer (GC), we conducted, for the first time, genome-wide lncRNA screening analysis in two sets of samples: five paired preoperative and postoperative day 14 plasma samples from GC patients, and tissue samples from tumor and adjacent normal tissues. Candidate tumor-related lncRNAs were then quantitated and evaluated in three independent phases comprising 321 participants...
2017: Theranostics
https://www.readbyqxmd.com/read/28032309/the-general-expression-analysis-of-wtx-gene-in-normal-and-cancer-tissues
#14
Yao-Yao Zhang, Qi-Ming Wang, Hui-Lin Niu, Xia Liu, Qing-Ling Zhang
WTX (Wilms' tumor suppressor X chromosome) is a novel putative tumor suppressor gene in Wilms' tumor of kidney, its expression and function in other human cancers had not been explored. This study detected the expression of WTX in 459 cases of 15 organs of cancers and adjacent normal tissues by using immunohistochemical staining (IHC), and validated them by in situ hybridization (ISH) and quantitative real-time reverse transcription PCR (qRT-PCR). IHC and ISH data showed that WTX protein was generally expressed in normal tissues, but reduced expression in corresponding cancers...
December 28, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28028765/an-alternative-method-for-screening-gastric-cancer-based-on-serum-levels-of-cea-ca19-9-and-ca72-4
#15
Junxiu Yu, Wanlei Zheng
PURPOSE: The goal of this study was to create a novel method for screening gastric cancer (GC) based on serum levels of carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9), and cancer antigen 72-4 (CA72-4) tumor markers. METHODS: Retrospectively, the predictive value for GC was calculated using a logistic analysis on serum levels of CEA, CA19-9, and CA72-4 from 216 GC and 49 benign patients. The predictive value was used to make a recommendation system on whether further GC screening was necessary...
December 28, 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28026832/significance-of-syt8-for-the-detection-prediction-and-treatment-of-peritoneal-metastasis-from-gastric-cancer
#16
Mitsuro Kanda, Dai Shimizu, Haruyoshi Tanaka, Chie Tanaka, Daisuke Kobayashi, Masamichi Hayashi, Naoki Iwata, Yukiko Niwa, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Kenta Murotani, Michitaka Fujiwara, Yasuhiro Kodera
OBJECTIVE: To develop novel diagnostic and therapeutic targets specific for peritoneal metastasis of gastric cancer (GC). BACKGROUND: Advanced GC frequently recurs because of undetected micrometastases even after curative resection. Peritoneal metastasis has been the most frequent recurrent pattern after gastrectomy and is incurable. METHODS: We conducted a recurrence pattern-specific transcriptome analysis in an independent cohort of 16 patients with stage III GC who underwent curative gastrectomy and adjuvant S-1 for screening candidate molecules specific for peritoneal metastasis of GC...
December 6, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/28025252/various-sulfated-carbohydrate-tumor-marker-candidates-identified-by-focused-glycomic-analyses
#17
Miki Tanaka-Okamoto, Mikio Mukai, Hidenori Takahashi, Yoshiyuki Fujiwara, Masayuki Ohue, Yasuhide Miyamoto
Glycomic analysis focused on sulfated O-glycans was performed to identify novel serum carbohydrate tumor markers. Sulfated glycans were enriched by α-neuraminidase digestion of pyridylaminated glycans prepared from sera, followed by anion exchange chromatography. Sulfated O-glycan profiles were constructed by two types of high performance liquid chromatography separation. Comparison of the profiles from 20 healthy controls with those of 11 gastric and 9 pancreatic cancer patients identified 14 marker candidates...
December 26, 2016: Glycobiology
https://www.readbyqxmd.com/read/28011897/association-between-polymorphisms-of-thymidylate-synthase-gene-5-and-3-utr-and-gastric-cancer-risk-meta-analysis
#18
Ao Mo, Yongliang Zhao, Yan Shi, Feng Qian, Yingxue Hao, Jun Chen, Shiwei Yang, Yuxing Jiang, Ziyan Luo, Peiwu Yu
Gastric cancer is the most common cancer and the most frequent cause of cancer death worldwide. Several studies have identified the role of thymidylate synthase (TS) 5'- and 3'-UTR and gastric cancer susceptibility; however, the results still remain inconclusive. The purpose of this meta-analysis was to reinvestigate this correlation. In the present study, online databases were searched to retrieve relevant articles published between January 2000 and 2016. The odds ratio (OR) and 95% confidence interval (CI) were employed to calculate the strength of association...
December 2016: Bioscience Reports
https://www.readbyqxmd.com/read/28009992/identification-of-a-synonymous-variant-in-trim59-gene-for-gastric-cancer-risk-in-a-chinese-population
#19
Dakui Luo, Younan Wang, Xiangkun Huan, Chi Huang, Chao Yang, Hao Fan, Zekuan Xu, Li Yang
Tripartite motif 59 (TRIM59) is a novel oncogenic driver in gastric cancer (GC) that is implicated in disease progression as well as dismal survival. Genetic variants in peculiar gene are likely candidates for conferring hereditary susceptibility. The role of TRIM59 polymorphism in predicting the risk of malignant diseases and its relevance to TRIM59 expression have not been discussed. Using a HapMap tagSNPs approach, we screened three tag TRIM59 single nucleotide polymorphisms (SNPs) (rs1141023G>A, rs7629A>G, rs11706810T>C) which were genotyped in 602 GC patients and 868 healthy controls...
December 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27994509/mir-99a-and-mir-491-regulate-cisplatin-resistance-in-human-gastric-cancer-cells-by-targeting-capns1
#20
Yajie Zhang, Wenxia Xu, Pan Ni, Aiping Li, Jianwei Zhou, Shan Xu
Cisplatin is the first-line agent utilized for the clinical treatment of a wide variety of solid tumors including gastric cancer. However, the intrinsic or acquired cisplatin resistance is often occurred in patients with gastric cancer and resulted in failure of cisplatin therapy. In order to investigate if miRNA involves in cisplatin resistance of human gastric cancer, we first screened and compared the expression of miRNAs between cisplatin resistant gastric cancer cell lines SGC-7901/DDP and BGC-823/DDP and their sensitive parental cells by miRNAs microarray and followed by analysis of 2D-GE/MS to identify their target proteins...
2016: International Journal of Biological Sciences
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