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screening gastric cancer

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https://www.readbyqxmd.com/read/28436254/the-correlation-between-histological-gastritis-staging-olga-olgim-and-serum-pepsinogen-test-in-assessment-of-gastric-atrophy-intestinal-metaplasia-in-china
#1
Xiaoteng Wang, Bin Lu, Lina Meng, Yihong Fan, Shuo Zhang, Meng Li
BACKGROUND: Serum pepsinogen (PG) test, as an indicator of gastric mucosal atrophy, reflects the functional and morphologic status of gastric mucosal and it is suggested to serve as a useful predictive marker for patients with gastric cancer (GC). The available classifications of gastritis, known as the Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Intestinal Metaplasia (OLGIM), integrating the severity and topography of atrophy/intestinal metaplasia (IM), have been gradually accepted and used in screening for GC in recent years...
April 22, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28433795/helicobacter-pylori-cagl-amino-acid-polymorphism-d58e59-pave-the-way-toward-peptic-ulcer-disease-while-n58e59-is-associated-with-gastric-cancer-in-north-of-iran
#2
Mina Rezaee Cherati, Javad Shokri-Shirvani, Ahmad Karkhah, Ramzan Rajabnia, Hamid Reza Nouri
The cagL protein of Helicobacter pylori involving in pathogenesis of gastroduodenal disorders. Therefore, the current study was conducted to determine the cagL amino acid polymorphisms in patients with gastric diseases. One hundred gastric biopsies were collected from gastritis, peptic ulcer (PUD) and gastric cancer (GC) patients and were screened for cagL using polymerase chain reaction (PCR). Also, sequence variations of the cagL were assessed via sequence translation. The cagL geneopositivity was 71.6% in patients were infected with H...
April 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28428723/what-is-the-quantitative-risk-of-gastric-cancer-in-the-first-degree-relatives-of-patients-a-meta-analysis
#3
Mohammad Yaghoobi, Julia McNabb-Baltar, Raheleh Bijarchi, Richard H Hunt
AIM: To quantify the risk of gastric cancer in first-degree relatives of patients with the cancer. METHODS: A comprehensive literature search was performed. Case-control trials comparing the frequency of a positive family history of gastric cancer in patients with gastric cancer, vs non-gastric cancer controls were retrieved. Studies with missed or non-extractable data, studies in children, abstracts, and duplicate publications were excluded. A meta-analysis of pooled odd ratios was performed using Review Manager 5...
April 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28423629/polymorphisms-in-human-telomerase-reverse-transcriptase-htert-gene-gene-gene-and-gene-smoking-interaction-with-susceptibility-to-gastric-cancer-in-chinese-han-population
#4
Jian Zhang, Hui Ju, Jun-Ru Gao, Xue-Long Jiao, Yun Lu
AIMS: To investigate the association of telomerase reverse transcriptase (TERT) gene polymorphisms and additional gene-gene and gene- environment interaction with gastric cancer (GC) risk. RESULTS: GC risk was significantly higher in carriers of G allele of rs2736100 than those with TT genotype (TG+ GG versus TT), adjusted OR (95%CI) =1.68 (1.26-2.17), and higher in carriers of G allele of rs2853669 than those with AA genotype (AG+ GG versus AA), adjusted OR (95%CI) = 1...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418920/complementary-utility-of-targeted-next-generation-sequencing-and-immunohistochemistry-panels-as-a-screening-platform-to-select-targeted-therapy-for-advanced-gastric-cancer
#5
Hyo Song Kim, Hanna Lee, Su-Jin Shin, Seung-Hoon Beom, Minkyu Jung, Sujin Bae, Eun Young Lee, Kyu Hyun Park, Yoon Young Choi, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Woong Sub Koom, Joon Seok Lim, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Hyunki Kim, Soonmyung Paik
We tested the clinical utility of combined profiling of Ion Torrent PGM based next-generation sequencing (NGS) and immunohistochemistry (IHC) for assignment to molecularly targeted therapies. A consecutive cohort of 93 patients with advanced/metastatic GC who underwent palliative chemotherapy between March and December 2015 were prospectively enrolled. Formalin fixed paraffin embedded tumor biopsy specimens were subjected to a 10 GC panels [Epstein Barr virus encoding RNA in-situ hybridization, IHC for mismatch repair proteins (MMR; MLH1, PMS2, MSH2, and MSH6), receptor tyrosine kinases (HER2, EGFR, and MET), PTEN, and p53 protein], and a commercial targeted NGS panel of 52 genes (Oncomine Focus Assay)...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415645/peritoneal-carcinomatosis-limits-of-diagnosis-and-the-case-for-liquid-biopsy
#6
REVIEW
James R W McMullen, Matthew Selleck, Nathan R Wall, Maheswari Senthil
Peritoneal Carcinomatosis (PC) is a late stage manifestation of several gastrointestinal malignancies including appendiceal, colorectal, and gastric cancer. In PC, tumors metastasize to and deposit on the peritoneal surface and often leave patients with only palliative treatment options. For colorectal PC, median survival is approximately five months, and palliative systemic therapy is able to extend this to approximately 12 months. However, cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) with a curative intent is possible in some patients with limited tumor burden...
March 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413641/serum-mir-20a-is-a-promising-biomarker-for-gastric-cancer
#7
Ruirui Yang, Yun Fu, Ying Zeng, Mengqin Xiang, Yufang Yin, Li Li, Haifan Xu, Jing Zhong, Xi Zeng
Gastric cancer (GC) is a common type of cancer, particularly in China. Numerous studies have demonstrated that circulating microRNAs (miRNAs) have potential applications as noninvasive biomarkers for cancer diagnosis and prognosis. Microarray-based serum miRNA profiling was performed on the serum of 12 paired pre- and post-operative GC patients to screen differentially expressed serum miRNAs. Twelve different serum miRNAs between pre- and post-operative GC patients were identified. Those miRNAs were verified by real-time quantitative polymerase chain reaction in 110 paired pre- and post-operative serum samples from 55 GC patients...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28404551/endocervical-gastric-type-adenocarcinoma-an-unrelated-hpv-tumour-difficulties-in-screening-and-diagnosis
#8
Priscila Carneiro Lima, Julio Teixeira, Guilherme Nogueira Aires, Liliana De Angelo Andrade
Gastric-type adenocarcinoma of the cervix (GAS) is an uncommon and aggressive tumour unrelated to human papillomavirus (HPV) infection with distinctive histological and immunohistochemical characteristics. GAS may be associated with lobular endocervical glandular hyperplasia (LEGH), another unusual lesion. We report a case of a 59-year-old woman with screening cytology 'AGC-Neo' and cervical conisation exhibiting cervical intraepithelial neoplasia grade 1, extensive LEGH and canal sampling with abundant mucinous cells...
April 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28400994/pathological-diagnosis-of-gastric-cancers-with-a-novel-computerized-analysis-system
#9
Kosuke Oikawa, Akira Saito, Tomoharu Kiyuna, Hans Peter Graf, Eric Cosatto, Masahiko Kuroda
BACKGROUND: Recent studies of molecular biology have provided great advances for diagnostic molecular pathology. Automated diagnostic systems with computerized scanning for sampled cells in fluids or smears are now widely utilized. Automated analysis of tissue sections is, however, very difficult because they exhibit a complex mixture of overlapping malignant tumor cells, benign host-derived cells, and extracellular materials. Thus, traditional histological diagnosis is still the most powerful method for diagnosis of diseases...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/28397474/evaluation-of-the-three-customized-msi-panels-to-improve-the-detection-of-microsatellite-instability-in-gastric-cancer
#10
Joonhong Park, Soyoung Shin, Han Mo Yoo, Seung-Woo Lee, Jeong Goo Kim
BACKGROUND: We designed and evaluated the suitability of three customized microsatellite instability (MSI) panels using a combination of mono- and dinucleotide markers to improve the detection of MSI status in 56 matched normal and gastric cancer specimens. METHODS: An MSI analysis was performed to optimize the panel of microsatellite markers to detect instability using two different microsatellite panels: (1) mononucleotide marker panel consisting of mononucleotide markers BAT25, BAT26, BAT40, BAT-RII, NR21, NR22, NR24, and NR27 and (2) dinucleotide marker panel containing D2S123, D5S346, D17S250, D17S261, D17S520, D18S34, and D18S58...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28371166/rapid-urine-antibody-test-for-helicobacter-pylori-infection-in-adolescents
#11
Masumi Okuda, Katsuhiro Mabe, Yingsong Lin, Wang Chaochen, Yohei Taniguchi, Mototsugu Kato, Shogo Kikuchi
BACKGROUND: Helicobacter pylori infection is associated with gastric cancer; thus, early diagnosis and treatment are crucial. Since H. pylori infection in adolescents or young adults shows few symptoms, screening tests are necessary for this population. In this study, the accuracy of the rapid urine-H. pylori antibody (u-HpAb) test was evaluated and compared to that of urine and serum H. pylori enzyme-linked immunosorbent assays (u-HpELISA and s-HpELISA, respectively) in junior high school students...
March 29, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28365944/mutual-information-network-based-support-vector-machine-strategy-identifies-salivary-biomarkers-in-gastric-cancer
#12
Yu-Gang Xu, Ming Cheng, Xia Zhang, Shi-Hai Sun, Wei-Min Bi
PURPOSE: To determine the vital salivary transcriptomic biomarkers for the early detection of gastric cancer via comparing classification efficiency of multiple candidate genes. METHODS: We firstly identified 5 kinds of candidate genes related to gastric cancer, including differential pathway genes (DPGs) based on the attract method, hub genes in differential pathways based on mutual information network (MIN) analysis, differentially expressed genes (DEGs) identified by Significance Analysis of Microarrays (SAM), informative genes (DEGs in differential pathways), and key genes (hub DEGs)...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28363756/her2-as-an-emerging-oncotarget-for-colorectal-cancer-treatment-after-failure-of-anti-epidermal-growth-factor-receptor-therapy
#13
REVIEW
Naoki Takegawa, Kimio Yonesaka
Amplification of the HER2 gene is an indicator of poor prognosis for several kinds of malignancies such as breast and gastric cancer, and anti-HER2 targeting therapies provide clinical benefits in these patients. In 2011, HER2 was identified as a resistance molecule for de novo and secondary anti-epidermal growth factor receptor (EGFR) antibody therapy. HER2 activation provides a bypass signaling pathway after anti-EGFR antibody treatment of colorectal cancer. Cell line-based screening revealed that HER2 genomic amplification induces resistance to the anti-EGFR antibody cetuximab in colorectal cancer...
March 9, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28343837/gastrointestinal-cancers-screening-and-early-detection
#14
REVIEW
Joyce P Griffin-Sobel
OBJECTIVE: To present an overview of current practices in the screening and early detection of gastrointestinal cancers. DATA SOURCES: Literature reviews. CONCLUSION: Screening for gastrointestinal cancers is less than desirable, particularly in underserved populations. There are inadequate methods of screening for early detection of esophageal and gastric cancers. IMPLICATIONS FOR NURSING PRACTICE: Education of patients is needed to reinforce the importance of screening for gastrointestinal cancers...
March 23, 2017: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/28341869/the-profile-of-serum-micrornas-predicts-prognosis-for-resected-gastric-cancer-patients-receiving-platinum-based-chemotherapy
#15
Jianning Song, Jie Yin, Zhigang Bai, Jun Zhang, Hua Meng, Jun Cai, Wei Deng, Xuemei Ma, Zhongtao Zhang
BACKGROUND AND AIM: Adjuvant chemotherapy is an important component in the treatment of gastric cancer (GC) patients; however, some patients do not respond to the drugs. We aimed to develop a practical profile based on serum microRNAs (miRNAs) that can be used to predict patients likely to respond to treatment. METHODS: Microarrays were used to screen cisplatin-resistant SGC7901/DDP GC cells and the parental SGC7901 cell lines for miRNAs related to chemotherapy sensitivity...
May 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28334893/a-new-score-for-screening-of-malnutrition-in-patients-with-inoperable-gastric-adenocarcinoma
#16
Ali Esfahani, Mohammad Hossein Somi, Mohammad Asghari Jafarabadi, Alireza Ostadrahimi, Mousa Ghayour Nahand, Zahra Fathifar, Akram Doostzadeh, Zohreh Ghoreishi
Background: Malnutrition is common in patients with gastric cancer. Early identification of malnourished patients results in improving quality of life. We aimed to assess the nutritional status of patients with inoperable gastric adenocarcinoma (IGA) and finding a precise malnutrition screening score for these patients before the onset of chemotherapy. Methods: Nutritional status was assessed using patient generated subjective global assessment (PG-SGA), visceral proteins, and high-sensitivity C reactive protein...
March 10, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28331560/introducing-crucial-protein-panel-of-gastric-adenocarcinoma-disease
#17
Mostafa Rezaei-Tavirani, Majid Rezaei-Tavirani, Vahid Mansouri, Seyed Mohammad Mahdavi, Reza Valizadeh, Mohammad Rostami-Nejad, Mohammad Reza Zali
AIM: Since interactome analysis of diseases can provide candidate biomarker panel related to the diseases, in this research, protein-protein interaction (PPI) network analysis is used to introduce the involved crucial proteins in Gastric adenocarcinoma (GA). BACKGROUND: Gastric adenocarcinoma (GA) is the most common type of stomach cancer. There is no efficient diagnostic molecular method for GA. METHOD: Applying Cytoscape software 3.4.0 and String Database, the PPI network was constructed for 200 genes...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28330821/beyond-precision-surgery-molecularly-motivated-precision-care-for-gastric-cancer
#18
REVIEW
Y Y Choi, J-H Cheong
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Despite the high disease prevalence, gastric cancer research has not gained much attention. Recently, genome-scale technology has made it possible to explore the characteristics of gastric cancer at the molecular level. Accordingly, gastric cancer can be classified into molecular subtypes that convey more detailed information of tumor than histopathological characteristics, and these subtypes are associated with clinical outcomes...
May 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28323271/a-serological-biopsy-using-five-stomach-specific-circulating-biomarkers-for-gastric-cancer-risk-assessment-a-multi-phase-study
#19
Huakang Tu, Liping Sun, Xiao Dong, Yuehua Gong, Qian Xu, Jingjing Jing, Roberd M Bostick, Xifeng Wu, Yuan Yuan
OBJECTIVES: We aimed to assess a serological biopsy using five stomach-specific circulating biomarkers-pepsinogen I (PGI), PGII, PGI/II ratio, anti-Helicobacter pylori (H. pylori) antibody, and gastrin-17 (G-17)-for identifying high-risk individuals and predicting risk of developing gastric cancer (GC). METHODS: Among 12,112 participants with prospective follow-up from an ongoing population-based screening program using both serology and gastroscopy in China, we conducted a multi-phase study involving a cross-sectional analysis, a follow-up analysis, and an integrative risk prediction modeling analysis...
March 21, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28292264/establishment-of-patient-derived-gastric-cancer-xenografts-a-useful-tool-for-preclinical-evaluation-of-targeted-therapies-involving-alterations-in-her-2-met-and-fgfr2-signaling-pathways
#20
Haiyong Wang, Jun Lu, Jian Tang, Shitu Chen, Kuifeng He, Xiaoxia Jiang, Weiqin Jiang, Lisong Teng
BACKGROUND: Targeted therapies are emerging treatment options for gastric cancer (GC). Patient-derived tumor xenograft(PDX) models of GC closely retain the features of the original clinical cancer, offering a powerful tool for preclinical drug efficacy testing. This study aimed to establish PDX GC models, and explore therapeutics targeting Her2, MET(cMet), and FGFR2, which may assist doctor to select the proper target therapy for selected patients. METHODS: GC tissues from 32 patients were collected and implanted into immuno-deficient mice...
March 14, 2017: BMC Cancer
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