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screening gastric cancer

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https://www.readbyqxmd.com/read/29332342/study-on-the-association-between-pi3k-akt-mtor-signaling-pathway-gene-polymorphism-and-susceptibility-to-gastric-cancer
#1
Lei Qi, Kewen Sun, Yun Zhuang, Jing Yang, Jianping Chen
PURPOSE: Excessive activation of PI3K/AKT/mTOR signaling pathway is one of the most common changes in human cancers, and single nucleotide polymorphisms (SNPs) existing in its functional region can affect the occurrence process of a variety of cancers. This study aimed to screen out the SNPs associated with susceptibility to gastric cancer in the PI3K/AKT/mT0R signaling pathway. METHODS: In this case-control study, the tagging SNPs in the promoter region5'-UTR, exon region or 3'-UTR of PIK3CA, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3 and mTOR genes were screened out...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29329543/stat3-induced-lncrna-haglros-overexpression-contributes-to-the-malignant-progression-of-gastric-cancer-cells-via-mtor-signal-mediated-inhibition-of-autophagy
#2
Jin-Fei Chen, Peng Wu, Rui Xia, Jian Yang, Xin-Ying Huo, Dong-Ying Gu, Cui-Ju Tang, Wei De, Fen Yang
BACKGROUND: Long noncoding RNAs (lncRNAs) are an important class of functional regulators involved in human cancers development, including gastric cancer (GC). Studying aberrantly expressed lncRNAs may provide us with new insights into the occurrence and development of gastric cancer by acting as oncogenes or tumor suppressors. In this study, we aim to examine the expression pattern of lncRNA HAGLROS in GC and its clinical significance as well as its biological role in tumor progression...
January 12, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29328491/microrna-let-7a-regulates-cell-autophagy-by-targeting-rictor-in-gastric-cancer-cell-lines-mgc-803-and-sgc-7901
#3
Hao Fan, Mingkun Jiang, Bowen Li, Yu He, Chi Huang, Dakui Luo, Hao Xu, Li Yang, Jundong Zhou
miR-let-7a is the most widely studied miRNA, whose functions have been well-established by scientists in both carcinogenesis and progression of human cancer, including gastric cancer (GC). However, to date there is a lack of information concerning the relationship between miR-let-7a and cellular autophagy. Using western blotting and immunofluorescence, we determined that upregulation of miR-let-7a led to increased cellular autophagic level, whereas miR-let-7a suppression decreased autophagy activity in GC cells...
January 5, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29328368/identification-of-significant-biomarkers-and-pathways-associated-with-gastric-carcinogenesis-by-whole-genome-wide-expression-profiling-analysis
#4
Hong-Jun Fei, Song-Chang Chen, Jun-Yu Zhang, Shu-Yuan Li, Lan-Lan Zhang, Yi-Yao Chen, Chun-Xin Chang, Chen-Ming Xu
The incidence of gastric cancer (GC) is extremely high in East Asia. GC is also one of the most common and lethal forms of cancer from a global perspective. However, to date, we have not been able to determine one or several genes as biomarkers in the diagnosis of GC and have also been unable to identify the genes which are important in the therapy of GC. In this study, we analyzed all genome-wide expression profiling arrays uploaded onto the Gene Expression Omnibus (GEO) database to filtrate the differentially expressed genes (DEGs) between normal stomach tissues and GC tissues...
January 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29318416/air-bubble-sign-a-new-screening-method-for-anastomotic-leakage-after-esophagectomy-for-esophageal-cancer
#5
Yoshiaki Shoji, Hiroya Takeuchi, Kazumasa Fukuda, Rieko Nakamura, Norihito Wada, Hirofumi Kawakubo, Yuko Kitagawa
BACKGROUND: Contrast esophagography often is performed to screen for anastomotic leakage (AL) after esophagectomy. However, its sensitivity remains low. Adverse events also have been reported. This report describes a new screening method to detect AL on computed tomography (CT) after esophagectomy. METHODS: From January 2012 to December 2015, 185 patients with esophageal cancer underwent surgical resection at the authors' institution. The study comparatively reviewed patient characteristics, surgical outcomes, and findings from postoperative CT images and contrast esophagrams of 142 patients who underwent esophagectomy followed by primary gastric conduit reconstruction through a posterior mediastinum route...
January 9, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29315389/cancer-screening-guidelines-and-policy-making-15-years-of-experience-in-cancer-screening-guideline-development-in-japan
#6
Chisato Hamashima
Cancer deaths have remained a heavy burden in Japan, thus cancer screening has been anticipated to be a practical strategy for reducing mortality from cancers. The Basic Plan to Promote Cancer Control Program published in 2006 stated that evidence-based cancer screening is required. At the conception of national cancer screening programs, there were no cancer screening assessments. From 1998 to 2001, Hisamichi formed committees for the assessment of cancer screening and published three reports. These reports were the cornerstone in assessing primary studies of cancer screening in Japan which served as a stimulus for the development of cancer screening guidelines...
January 5, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29305976/functional-long-non-coding-rnas-associated-with-gastric-cancer-susceptibility-and-evaluation-of-the-epidemiological-efficacy-in-a-central-chinese-population
#7
Fujiao Duan, Jicheng Jiang, Chunhua Song, Peng Wang, Hua Ye, Liping Dai, Jianying Zhang, Kaijuan Wang
AIM: To screen and validate the gastric cancer-associated long non-coding RNAs (lncRNAs) and their functional single nucleotide polymorphisms (SNPs). METHODS: Based on case-control design, we select the differentially expressed lncRNAs by bioinformation tools and validate SNPs in lncRNAs genes in population. Attributable risk percentage (ARP) and population attributable risk percentage (PARP) were used to assess the effect of epidemiology. RESULTS: Four lncRNAs with SNPs (lnc-EVX1-3:3 (rs1859168), lnc-MACC1-1:7 (rs3815254), lnc-AMFR-1:1 (rs4784659) and lnc-ZNF33B-2:1 (rs579501)) were selected to be validated in population...
January 3, 2018: Gene
https://www.readbyqxmd.com/read/29295970/construction-and-comprehensive-analysis-for-dysregulated-long-non-coding-rna-lncrna-associated-competing-endogenous-rna-cerna-network-in-gastric-cancer
#8
Fengxi Li, Chuiguo Huang, Qian Li, Xianghua Wu
Long non-coding RNA (lncRNA) is a kind of non-coding RNA with transcripts more than 200 bp in length. LncRNA can interact with the miRNA as a competing endogenous RNA (ceRNA) to regulate the expression of target genes, which play a significant role in the initiation and progression of tumors. In this study, we explored the functional roles and regulatory mechanisms of lncRNAs as ceRNAs in gastric cancer, and their potential implications for prognosis. The lncRNAs, miRNAs, and mRNAs expression profiles of 375 gastric cancer tissues and 32 non-tumor gastric tissues were downloaded from The Cancer Genome Atlas (TCGA) database...
January 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29288114/efficacy-of-fast-track-surgery-in-laparoscopic-radical-gastrectomy-for-gastric-cancer-a-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
Qing Liu, Li Ding, Honglei Jiang, Chundong Zhang, Junzhe Jin
OBJECTIVE: To conduct a systematic review of efficacy and security of fast track surgery (FTS) in laparoscopic radical gastrectomy for gastric cancer. METHODS: We searched PubMed, Embase, and Cochrane Library Databases and supplemented by other searches to collect randomized controlled trials (RCTs) on the comparison of fast track surgery combined with laparoscopy versus laparoscopy separately used in radical gastrectomy for gastric cancer before December 2016. After screening for inclusion, data extraction, and quality assessment, meta-analysis was conducted by the Review Manager 5...
December 26, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29286091/identifying-heterogeneous-subtypes-of-gastric-cancer-and-subtype%C3%A2-specific-subpaths-of-microrna%C3%A2-target-pathways
#10
Yuanhang Li, Weijun Bai, Xu Zhang
The present study aimed to classify gastric cancer (GC) into subtypes and to screen the subtype‑specific genes, their targeted microRNAs (miRNAs) and enriched pathways to explore the putative mechanism of each GC subtypes. The GSE13861 data set was downloaded from the Gene Expression Omnibus and used to screen differential expression genes (DEGs) in GC samples based on the detection of imbalanced differential signal algorithm. The specific genes in each subtype were identified with the cut‑off criterion of U>0...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29282891/identification-of-a-novel-gene-pairs-signature-in-the-prognosis-of-gastric-cancer
#11
Pai-Lan Peng, Xiang-Yu Zhou, Guo-Dong Yi, Peng-Fei Chen, Fan Wang, Wei-Guo Dong
Current prognostic signatures need to be improved in identifying high-risk patients of gastric cancer (GC). Thus, we aimed to develop a reliable prognostic signature that could assess the prognosis risk in GC patients. Two microarray datasets of GSE662254 (n = 300, training set) and GSE15459 (n = 192, test set) were included into analysis. Prognostic genes were screened to construct prognosis-related gene pairs (PRGPs). Then, a penalized Cox proportional hazards regression model identified seven PRGPs, which constructed a prognostic signature and divided patients into high- and low-risk groups according to the signature score...
December 28, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29282156/examining-cancer-survivorship-trajectories-exploring-the-intersection-between-qualitative-illness-narratives-and-quantitative-screening-instruments
#12
Chelsea Ratcliff, Aanand D Naik, Lindsey Ann Martin, Jennifer Moye
OBJECTIVE: This article examines the associations of quantitatively refined trajectories of adjustment to cancer survivorship determined by previously published qualitative narrative analysis. METHOD: Patients completed measures of cancer-related worry (Cancer Related Worries Scale), depression (Patient Health Questionnaire-9), posttraumatic growth (Benefit Finding Scale), and open-ended survey questions 6, 12, and 18 months postdiagnosis of head and neck, esophageal, gastric, or colorectal cancer...
December 28, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29279494/a-case-of-raoultella-planticola-bacteremia-in-a-patient-with-early-gastric-cancer
#13
Shotaro Yamamoto, Katsuya Nagatani, Takeo Sato, Takeyoshi Ajima, Seiji Minota
The patient was an 81-year-old man who was found to have bacteremia due to Raoultella planticola, which might have entered the circulation through the bile duct during the passing of a gallbladder stone. In the present case, we screened for malignancies because most cases of R. planticola bacteremia occur after trauma, invasive procedures, or in patients with malignancy (70.6%). Early gastric cancer was detected. Although the association between R. planticola bacteremia and malignancy remains speculative in the present case, it may be useful to scrutinize similar cases involving low-virulence bacteremia for possible malignancies or immune conditions...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29246751/generation-and-characterization-of-an-anti-delta-like-ligand-4-nanobody-to-induce-non-productive-angiogenesis
#14
Rasoul Baharlou, Nader Tajik, Mahdi Behdani, Mohammad Ali Shokrgozar, Amir Hassan Zarnani, Fatemeh Shahhosseini, Mahdi Habibi-Anbouhi
Antibody-based targeting of angiogenesis is a key approach for cancer treatment. Delta-like ligand 4 (DLL4) plays a pivotal role in tumor neovascular development and angiogenesis during tumor progression. It forecasts the prognosis of human malignancies and blocking its signaling can help to inhibit neovascularization and tumor metastasis. Nanobodies are the smallest antigen-binding domains of heavy chain antibodies in camelidae. The aim of this study was to develop a Nanobody against DLL4 and apply binding and functional approaches to target it...
December 12, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29246308/mir-3174-contributes-to-apoptosis-and-autophagic-cell-death-defects-in-gastric-cancer-cells-by-targeting-arhgap10
#15
Bowen Li, Lu Wang, Zheng Li, Weizhi Wang, Xiaofei Zhi, Xiaoxu Huang, Qiang Zhang, Zheng Chen, Xuan Zhang, Zhongyuan He, Jianghao Xu, Lu Zhang, Hao Xu, Diancai Zhang, Zekuan Xu
Gastric cancer (GC) is a major health problem worldwide because of its high morbidity and mortality. Considering the well-established roles of miRNA in the regulation of GC carcinogenesis and progression, we screened differentially expressed microRNAs (miRNAs) by using The Cancer Genome Atlas (TCGA) and the GEO databases. We found that miR-3174 was the most significantly differentially expressed miRNA in GC. Ectopic miR-3174 expression was also detected in clinical GC patient samples and cell lines and associated with poor patient prognosis...
December 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29245951/construction-of-a-model-predicting-the-risk-of-tube-feeding-intolerance-after-gastrectomy-for-gastric-cancer-based-on-225-cases-from-a-single-chinese-center
#16
Wu Xiaoyong, Li Xuzhao, Yu Deliang, Yu Pengfei, Hang Zhenning, Bai Bin, Li Zhengyan, Pang Fangning, Wang Shiqi, Zhao Qingchuan
Identifying patients at high risk of tube feeding intolerance (TFI) after gastric cancer surgery may prevent the occurrence of TFI; however, a predictive model is lacking. We therefore analyzed the incidence of TFI and its associated risk factors after gastric cancer surgery in 225 gastric cancer patients divided into without-TFI (n = 114) and with-TFI (n = 111) groups. A total of 49.3% of patients experienced TFI after gastric cancer. Multivariate analysis identified a history of functional constipation (FC), a preoperative American Society of Anesthesiologists (ASA) score of III, a high pain score at 6-hour postoperation, and a high white blood cell (WBC) count on the first day after surgery as independent risk factors for TFI...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29241848/gastroscopy-and-gastric-cancer-related-mortality-time-to-change-recommendations-regarding-screening
#17
EDITORIAL
Diogo Libânio, Mário Dinis-Ribeiro
No abstract text is available yet for this article.
January 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29240459/downregulated-expression-of-hsa_circ_0074362-in-gastric-cancer-and-its-potential-diagnostic-values
#18
Yi Xie, Yongfu Shao, Weiliang Sun, Guoliang Ye, Xinjun Zhang, Bingxiu Xiao, Junming Guo
AIM: To explore the diagnostic value of hsa_circ_0074362 in the screening of gastric cancer. METHODS: The expression levels of hsa_circ_0074362 in 127 gastric cancer tissues and paired adjacent normal tissues, 83 gastritis tissues and six gastric cancer cell lines were first detected by quantitative reverse transcription-polymerase chain reaction. Then, the relationship between its levels and clinicopathological factors of patients with gastric cancer was analyzed...
December 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29239137/medical-management-of-gastric-cancer-a-2017-update
#19
REVIEW
Nikolaos Charalampakis, Panagiota Economopoulou, Ioannis Kotsantis, Maria Tolia, Dimitrios Schizas, Theodore Liakakos, Elena Elimova, Jaffer A Ajani, Amanda Psyrri
Gastric cancer remains a considerable health burden throughout the world. The Cancer Genome Atlas (TCGA) analysis has recently unveiled 4 genotypes of gastric cancer with data not ready to change treatment strategy yet. A multimodality approach to therapy is the cornerstone of screening, diagnosing, staging, treating and supporting patients with gastric cancer. The evidence-based approach to localized gastric cancer (>cT1b) is to use an either preoperative or postoperative strategy to maximize the benefit of surgery...
December 13, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29237405/prevalence-and-characteristics-of-hereditary-non-polyposis-colorectal-cancer-hnpcc-syndrome-in-immigrant-asian-colorectal-cancer-patients
#20
Jasmine Lee, Yin-Yi Xiao, Yan Yu Sun, Jasminka Balderacchi, Bradley Clark, Jatin Desani, Vivek Kumar, Angela Saverimuthu, Khin Than Win, Yiwu Huang, Yiqing Xu
BACKGROUND: The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2, and EPCAM. A non-hereditary, acquired process of hypermethylation of the MLH1 promoter can also lead to silencing of MLH1 protein expression. Diagnosis of HNPCC in patients with colorectal and other related cancers is important in the clinical treatment and surveillance of related cancers...
December 13, 2017: BMC Cancer
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