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screening colorectal cancer

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https://www.readbyqxmd.com/read/29222172/proximal-aberrant-crypt-foci-associate-with-synchronous-neoplasia-and-are-primed-for-neoplastic-progression
#1
David A Drew, Allen Mo, James J Grady, Richard G Stevens, Joel B Levine, Bruce M Brenner, Joseph C Anderson, Faripour Forouhar, Michael J O'Brien, Thomas J Devers, Daniel W Rosenberg
Aberrant crypt foci (ACF) are the earliest morphologically identifiable lesion found within the human colon. Despite their relatively high frequency in the distal colon, few studies have examined the molecular characteristics of ACF within the proximal colon. In the following study, clinical participants (n=184) were screened for ACF using high-definition chromoendoscopy with contrast dye-spray. Following pathological confirmation, ACF biopsies were subjected to laser-capture microdissection (LCM) and epithelial cells were evaluated for somatic mutations with a customized colorectal cancer mutation panel using DNA-mass spectrometry...
December 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29221446/a-systematic-review-of-test-accuracy-studies-evaluating-molecular-micro-satellite-instability-testing-for-the-detection-of-individuals-with-lynch-syndrome
#2
Helen Coelho, Tracey Jones-Hughes, Tristan Snowsill, Simon Briscoe, Nicola Huxley, Ian M Frayling, Chris Hyde
BACKGROUND: A systematic review was conducted to assess the diagnostic test accuracy of polymerase chain reaction (PCR)-based microsatellite instability (MSI) testing for identifying Lynch syndrome in patients with colorectal cancer (CRC). Unlike previous reviews, this was based on assessing MSI testing against best practice for the reference standard, and included CRC populations that were unselected, age-limited or high-risk for Lynch syndrome. METHODS: Single- and two-gate diagnostic test accuracy studies, or similar, were identified, assessed for inclusion, data extracted and quality appraised by two reviewers according to a pre-specified protocol...
December 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29219921/colorectal-cancer-safety-net-is-it-catching-patients-appropriately
#3
Alison R Althans, Justin T Brady, Melissa L Times, Deborah S Keller, Alexis R Harvey, Molly E Kelly, Nilam D Patel, Scott R Steele
BACKGROUND: Disparities in access to colorectal cancer care are multifactorial and are affected by socioeconomic elements. Uninsured and Medicaid patients present with advanced stage disease and have worse outcomes compared with similar privately insured patients. Safety net hospitals are a major care provider to this vulnerable population. Few studies have evaluated outcomes for safety net hospitals compared with private institutions in colorectal cancer. OBJECTIVE: The purpose of this study was to compare demographics, screening rates, presentation stage, and survival rates between a safety net hospital and a tertiary care center...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29217301/-gut-microbiota-what-impact-on-colorectal-carcinogenesis-and-treatment
#4
REVIEW
Antoine Bruneau, Minh-Tam Baylatry, Anne Christine Joly, Harry Sokol
The gut microbiota, composed of 1014 microorganisms, is now considered as a "hidden organ", regarding to its digestive, metabolic and immune functions, which are helpful to its host. For the last 15 years, advances in molecular biology have highlighted the association of gut microbiota dysbiosis with several diseases, including colorectal cancer. An increased abundance of some bacteria (including Fusobacterium nucleatum, Bacteroides fragilis, Escherichia coli) is associated with cancer, whereas others seem to be protective (Faecalibacterium prausnitzii)...
December 4, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29215473/duodenal-adenomas-in-patients-with-multiple-colorectal-adenomas-without-germline-apc-or-mutyh-mutations
#5
Frank G J Kallenberg, Andrew Latchford, Nikki C Lips, Cora M Aalfs, Barbara A J Bastiaansen, Susan K Clark, Evelien Dekker
BACKGROUND: Patients with genetic adenomatous polyposis syndromes have an increased risk for duodenal cancer, and clear surveillance recommendations exist for this group. However, limited data are available on the duodenal phenotype of patients with multiple colorectal adenomas (10-99) without a germline APC or MUTYH mutation. OBJECTIVE: We aimed to assess the frequency, extent, and progression of duodenal adenomas in patients with multiple colorectal adenomas without a germline APC or MUTYH mutation...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29214818/colorectal-cancer-screening-completion-among-individuals-with-and-without-mental-illnesses-a-comparison-of-2-screening-methods
#6
Bobbi Jo H Yarborough, Ginger C Hanson, Nancy A Perrin, Scott P Stumbo, Carla A Green
PURPOSE: Cancer mortality is worse among people with psychiatric disorders. The purpose of this study was to compare facilitators and rates of colorectal cancer (CRC) screening between people with and without mental illnesses. DESIGN: We conducted a secondary analysis using data from a general population cohort study (N = 92 445) that assessed effects of 2 types of CRC screening test kits-guaiac fecal occult blood testing (gFOBT) and fecal immunochemical testing (FIT)-on CRC screening completion...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29214162/current-tissue-molecular-markers-in-colorectal-cancer-a-literature-review
#7
REVIEW
Gaia Peluso, Paola Incollingo, Armando Calogero, Vincenzo Tammaro, Niccolò Rupealta, Gaetano Chiacchio, Maria Laura Sandoval Sotelo, Gianluca Minieri, Antonio Pisani, Eleonora Riccio, Massimo Sabbatini, Umberto Marcello Bracale, Concetta Anna Dodaro, Nicola Carlomagno
Background: Colorectal cancer (CRC) is one of the most spread neoplasia types all around the world, especially in western areas. It evolves from precancerous lesions and adenomatous polyps, through successive genetic and epigenetic mutations. Numerous risk factors intervene in its development and they are either environmental or genetic. Aim of the Review: Alongside common screening techniques, such as fecal screening tests, endoscopic evaluation, and CT-colonography, we have identified the most important and useful biomarkers and we have analyzed their role in the diagnosis, prevention, and prognosis of CRC...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29212310/quality-metrics-of-a-fecal-immunochemical-test-based-colorectal-cancer-screening-program-in-korea
#8
Dae Ho Kim, Jae Myung Cha, Min Seob Kwak, Jin Young Yoon, Young-Hak Cho, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Joung Il Lee
Background/Aims: Knowledge regarding the quality metrics of fecal immunochemical test (FIT)-based colorectal cancer screening programs is limited. The aim of this study was to investigate the performance and quality metrics of a FIT-based screening program. Methods: In our screening program, asymptomatic subjects aged ≥50 years underwent an annual FIT, and subjects with positive FIT results underwent a subsequent colonoscopy. The performance of the FIT and colonoscopy was analyzed in individuals with a positive FIT who completed the program between 2009 and 2015 at a university hospital...
December 8, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29212164/targeted-sequencing-of-established-and-candidate-colorectal-cancer-genes-in-the-colon-cancer-family-registry-cohort
#9
Leon Raskin, Yan Guo, Liping Du, Mark Clendenning, Christophe Rosty, Noralane M Lindor, Stephen B Gruber, Daniel D Buchanan
The underlying genetic cause of colorectal cancer (CRC) can be identified for 5-10% of all cases, while at least 20% of CRC cases are thought to be due to inherited genetic factors. Screening for highly penetrant mutations in genes associated with Mendelian cancer syndromes using next-generation sequencing (NGS) can be prohibitively expensive for studies requiring large samples sizes. The aim of the study was to identify rare single nucleotide variants and small indels in 40 established or candidate CRC susceptibility genes in 1,046 familial CRC cases (including both MSS and MSI-H tumor subtypes) and 1,006 unrelated controls from the Colon Cancer Family Registry Cohort using a robust and cost-effective DNA pooling NGS strategy...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212101/invitation-letters-increase-participation-in-colorectal-cancer-screening-results-from-an-observational-study
#10
Tianzuo Zhan, Thomas Hielscher, Asmé Bilge, Thomas Giese, Christoph Schäfer, Jürgen F Riemann, Matthias P Ebert, Sebastian Belle
Background and Aim Participation rates in the German colorectal cancer screening program are low. Starting in 2013, a large health insurance plan in Bavaria, Germany, is sending an additional invitation letter to insured individuals when they turn 50 or 55 years and become eligible for participation in the program. The letter provides detailed information on colorectal cancer screening. We assessed the impact of the invitation letter on utilization rates. Methods Insurance claims data of a total of 48 343 individuals who had turned 50 or 55 years between 2012 to 2014 were reviewed for utilization rates of screening colonoscopy and fecal blood tests...
December 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29211316/the-efficacy-of-prostate-specific-antigen-screening-impact-of-key-components-in-the-erspc-and-plco-trials
#11
Harry J de Koning, Roman Gulati, Sue M Moss, Jonas Hugosson, Paul F Pinsky, Christine D Berg, Anssi Auvinen, Gerald L Andriole, Monique J Roobol, E David Crawford, Vera Nelen, Maciej Kwiatkowski, Marco Zappa, Marcos Luján, Arnauld Villers, Tiago M de Carvalho, Eric J Feuer, Alex Tsodikov, Angela B Mariotto, Eveline A M Heijnsdijk, Ruth Etzioni
BACKGROUND: The European Randomized Study of Screening for Prostate Cancer (ERSPC) demonstrated that prostate-specific antigen (PSA) screening significantly reduced prostate cancer mortality (rate ratio, 0.79; 95% confidence interval, 0.69-0.91). The US Prostate, Lung, Colorectal, and Ovarian (PLCO) trial indicated no such reduction but had a wide 95% CI (rate ratio for prostate cancer mortality, 1.09; 95% CI, 0.87-1.36). Standard meta-analyses are unable to account for key differences between the trials that can impact the estimated effects of screening and the trials' point estimates...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29210901/smoking-habits-are-strongly-associated-with-colorectal-polyps-in-a-population-based-case-control-study
#12
Naomi Fliss-Isakov, Shira Zelber-Sagi, Muriel Webb, Zamir Halpern, Revital Kariv
GOALS: The goal of this study is to test the association between lifetime smoking habits and colorectal polyps of different classifications. BACKGROUND: Smoking is an established risk factor for several cancers, including colorectal cancer. However, the association between lifetime smoking habits including intensity, duration, and cessation, and premalignant colorectal polyps is yet to be established. STUDY: A case-control study among 828 consecutive subjects aged 40 to 70 years, undergoing screening or diagnostic colonoscopy...
November 28, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29209625/prediction-and-validation-of-hub-genes-associated-with-colorectal-cancer-by-integrating-ppi-network-and-gene-expression-data
#13
Yongfu Xiong, Wenxian You, Rong Wang, Linglong Peng, Zhongxue Fu
Although hundreds of colorectal cancer- (CRC-) related genes have been screened, the significant hub genes still need to be further identified. The aim of this study was to identify the hub genes based on protein-protein interaction network and uncover their clinical value. Firstly, 645 CRC patients' data from the Tumor Cancer Genome Atlas were downloaded and analyzed to screen the differential expression genes (DEGs). And then, the Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis was performed, and PPI network of the DEGs was constructed by Cytoscape software...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29208881/clinicopathological-assessment-of-colorectal-carcinoma-in-mymensingh-medical-college-hospital-bangladesh
#14
M M Mahamud, F Wahed, J Ferdous, M K Khan
Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the US. It is mainly a disease of the developed countries with a western culture, yet the disease is not uncommon in developing countries. There is substantial geographical variation in the incidence and demographic characteristics of the disease. Variations are also observed in the risk factors, mode of presentation, sub site distribution and stage of the disease at presentation...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207642/crosstalk-in-competing-endogenous-rna-network-reveals-the-complex-molecular-mechanism-underlying-lung-cancer
#15
Xiang Jin, Yinghui Guan, Hui Sheng, Yang Liu
We investigated the transcriptional mechanism underlying lung cancer development. RNA sequencing analysis was performed on blood samples from lung cancer cases and healthy controls. Differentially expressed microRNAs (miRNAs), circular RNAs (circRNAs), mRNAs (genes), and long non-coding RNAs (lncRNA) were identified, followed by pathway enrichment analysis. Based on miRNA target interactions, a competing endogenous network was established and significant nodes were screened. Differentially expressed transcriptional factors were retrieved from the TRRUST database and the transcriptional factor regulatory network was constructed...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205185/knowledge-attitude-and-practices-of-primary-health-care-physicians-toward-colorectal-cancer-screening
#16
Mahmoud Mosli, Yaser Alnahdi, Abdusalam Alghamdi, Mohammad Baabdullah, Afnan Hadadi, Khaleel Khateery, Ibrahim Alsulami, Abdulaziz AlHoqail, Majid Almadi, Hani Jawa, Emad Aljahdli, Salem Bazarah, Yousif Qari
BACKGROUND/AIM: Early diagnosis of chronic illnesses and cancers mainly occurs at primary health care centers (PHCs) by primary health care physicians (PHPs). The incidence of colorectal cancer (CRC) in the Kingdom of Saudi Arabia (KSA) is rising and this has been attributed to many factors. The increasing incidence of CRC is compounded by nonadherence to screening recommendations. Therefore, evaluating PHPs knowledge, attitudes, and practices of screening for CRC is clinically important...
November 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29202003/implementation-of-an-optical-diagnosis-strategy-saves-costs-and-does-not-impair-clinical-outcomes-of-a-fecal-immunochemical-test-based-colorectal-cancer-screening-program
#17
Jasper L A Vleugels, Marjolein J E Greuter, Yark Hazewinkel, Veerle M H Coupé, Evelien Dekker
Background and study aims:  In an optical diagnosis strategy, diminutive polyps that are endoscopically characterized with high confidence are removed without histopathological analysis and distal hyperplastic polyps are left in situ. We evaluated the effectiveness and costs of optical diagnosis. Methods:  Using the Adenoma and Serrated pathway to Colorectal CAncer (ASCCA) model, we simulated biennial fecal immunochemical test (FIT) screening in individuals aged 55 - 75 years...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29201874/a-global-perspective-on-capsule-endoscopy
#18
REVIEW
Tanja Nowak
A search of the internet today to quantify the estimated value of capsules from a global perspective, easily delivers figures stating around $200 million in 2014 to about $400 million by 2020, which would be approximately 10% of the gastrointestinal endoscopic market. Is this a steep rise within just six years or could the capsule market do even better? What chances does this offer and what are the key aspects for future success? By 2020, more than 1 billion people are aged sixty or older and around one third of them will live in what the UN calls "more developed regions"...
November 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29201873/an-innovative-robotic-platform-for-magnetically-driven-painless-colonoscopy
#19
REVIEW
Federico Bianchi, Gastone Ciuti, Anastasios Koulaouzidis, Alberto Arezzo, Danail Stoyanov, Sebastian Schostek, Calogero Maria Oddo, Arianna Menciassi, Paolo Dario
Colorectal cancer (CRC) represents a significant medical threat with a dramatic impact on the healthcare system with around 1.3 million patients worldwide, causing more than 700 thousand deaths annually. A key-aspect to successful and cost-effective disease management is represented by the early detection of CRC at asymptomatic stage. For this reason, population screening is highly recommended for patients older than 50 years or at high risk for familiarity. Currently, the standard endoscopic techniques do not meet this need...
November 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29201802/hepatic-metastasis-from-colorectal-cancer
#20
Alan I Valderrama-Treviño, Baltazar Barrera-Mera, Jesús C Ceballos-Villalva, Eduardo E Montalvo-Javé
The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used. In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs...
July 2017: Euroasian Journal of Hepato-Gastroenterology
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