keyword
MENU ▼
Read by QxMD icon Read
search

screening colorectal cancer

keyword
https://www.readbyqxmd.com/read/28454418/epigenetic-silencing-of-protocadherin-10-in-colorectal-cancer
#1
Xian Zhong, Hong Shen, Jianshan Mao, Jiawei Zhang, Weidong Han
Colorectal cancer (CRC) is one of the most common types of malignant tumor in the world and occurs through a multi-step process resulting from the accumulation of genetic and epigenetic alterations of the genome. Although the molecular mechanisms of the pathogenesis of CRC remain unclear, the inactivation of tumor suppressor genes (TSGs) through promoter methylation serves an important role. Aberrant methylation is a well-defined marker of CRC. At present, the epigenetic silencing of protocadherin 10 (PCDH10) has been identified as an important TSG with key roles in colorectal carcinogenesis, invasion and metastasis as a frequent and early event...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28447326/ct-colonography-role-in-fobt-based-screening-programs-for-colorectal-cancer
#2
REVIEW
Lapo Sali, Grazia Grazzini, Mario Mascalchi
Computed tomographic colonography (CTC) is a minimally invasive imaging examination for the colon, and is safe, well tolerated and accurate for the detection of colorectal cancer (CRC) and advanced adenoma. While the role of CTC as a primary test for population screening of CRC is under investigation, the fecal occult blood test (FOBT) has been recommended for population screening of CRC in Europe. Subjects with positive FOBT are invited to undergo total colonoscopy, which has some critical issues, such as suboptimal compliance, contraindications and the possibility of an incomplete exploration of the colon...
April 26, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28447054/the-necessity-of-colorectal-cancer-screening-for-elderly-patients
#3
EDITORIAL
Shin-Ei Kudo, Toyoki Kudo
No abstract text is available yet for this article.
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28447052/what-is-the-optimal-colorectal-cancer-screening-program-for-an-average-risk-population
#4
EDITORIAL
Masau Sekiguchi, Takahisa Matsuda, Yutaka Saito
No abstract text is available yet for this article.
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28445947/characteristics-and-comparison-of-colorectal-cancer-incidence-in-beijing-with-other-regions-in-the-world
#5
Zhongmin Li, Lei Yang, Changzheng Du, Xuedong Fang, Ning Wang, Jin Gu
BACKGROUND: Population-based epidemiologic studies about colorectal cancer are lacking in China. This study aims to provide a basis for colorectal cancer screening and prevention, through analysis and comparisons the characteristics of the trends in colorectal cancer incidence in Beijing and selected representative regions. RESULTS: The annual incidence rate in Beijing region increased significantly, from 9.40/100,000 in 1998 to 18.61/100,000 in 2012. The stratified rate showed that the incidence of distal colon adenocarcinoma increased substantially in men, especially in those aged > 75 years and residing in urban areas...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28445277/cancer-studies-based-on-secondary-data-analysis-of-the-taiwan-s-national-health-insurance-research-database-a-computational-text-analysis-and-visualization-study
#6
Jui-Kun Chiang, Chih-Wen Lin, Chun-Lung Wang, Malcolm Koo, Yee-Hsin Kao
There has been a surge in the academic publication output based on secondary analyses of the data from the Taiwan's National Health Insurance claim records. It has become a challenge to comprehend such a rapid expansion of the literature. Therefore, this study aimed to explore the conceptual content of National Health Insurance Research Database-based cancer research, using the abstract of articles extracted from PubMed between 2002 and 2015. Search terms including "National Health Insurance Research Database (NHIRD) AND Taiwan," "Taiwan AND population-based," and "Taiwan AND nationwide" were used to search in PubMed with the publication date limited to between 1997 and 2015...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444278/association-between-time-to-colonoscopy-after-a-positive-fecal-test-result-and-risk-of-colorectal-cancer-and-cancer-stage-at-diagnosis
#7
Douglas A Corley, Christopher D Jensen, Virginia P Quinn, Chyke A Doubeni, Ann G Zauber, Jeffrey K Lee, Joanne E Schottinger, Amy R Marks, Wei K Zhao, Nirupa R Ghai, Alexander T Lee, Richard Contreras, Charles P Quesenberry, Bruce H Fireman, Theodore R Levin
Importance: The fecal immunochemical test (FIT) is commonly used for colorectal cancer screening and positive test results require follow-up colonoscopy. However, follow-up intervals vary, which may result in neoplastic progression. Objective: To evaluate time to colonoscopy after a positive FIT result and its association with risk of colorectal cancer and advanced-stage disease at diagnosis. Design, Setting, and Participants: Retrospective cohort study (January 1, 2010-December 31, 2014) within Kaiser Permanente Northern and Southern California...
April 25, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28441381/text-message-reminders-in-colorectal-cancer-screening-triccs-a-randomised-controlled-trial
#8
Yasemin Hirst, Hanna Skrobanski, Robert S Kerrison, Lindsay C Kobayashi, Nicholas Counsell, Natasha Djedovic, Josephine Ruwende, Mark Stewart, Christian von Wagner
BACKGROUND: We investigated the effectiveness of a text-message reminder to improve uptake of the English Bowel Cancer Screening programme in London. METHODS: We performed a randomised controlled trial across 141 general practices in London. Eight thousand two hundred sixty-nine screening-eligible adults (aged 60-74 years) were randomised in a 1 : 1 ratio to receive either a text-message reminder (n=4134) or no text-message reminder (n=4135) if they had not returned their faecal occult blood test kit within 8 weeks of initial invitation...
April 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28440872/lay-health-educators-and-print-materials-for-the-promotion-of-colorectal-cancer-screening-among-korean-americans-a-randomized-comparative-effectiveness-study
#9
Angela M Jo, Tung T Nguyen, Susan Stewart, Min J Sung, Ginny Gildengorin, Janice Y Tsoh, Elisa K Tong, Penny Lo, Charlene Cuaresma, Angela Sy, Hy Lam, Ching Wong, Matthew Jeong, Moon S Chen, Marjorie Kagawa-Singer
BACKGROUND: Colorectal cancer (CRC) is the second most commonly diagnosed cancer among Korean American men and women. Although CRC screening is effective in reducing the burden of this disease, studies have shown that Korean Americans have low screening rates. METHODS: The authors conducted a 2-arm cluster randomized controlled trial comparing a brochure (print) with a brochure and lay health educator (LHE) outreach (print + LHE) in increasing CRC screening rates among Korean American individuals...
April 25, 2017: Cancer
https://www.readbyqxmd.com/read/28439739/medical-mistrust-and-colorectal-cancer-screening-among-african-americans
#10
REVIEW
Leslie B Adams, Jennifer Richmond, Giselle Corbie-Smith, Wizdom Powell
Despite well-documented benefits of colorectal cancer (CRC) screening, African Americans are less likely to be screened and have higher CRC incidence and mortality than Whites. Emerging evidence suggests medical mistrust may influence CRC screening disparities among African Americans. The goal of this systematic review was to summarize evidence investigating associations between medical mistrust and CRC screening among African Americans, and variations in these associations by gender, CRC screening type, and level of mistrust...
April 24, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28439604/emergency-presentation-of-colorectal-cancer-in-northwestern-saudi-arabia
#11
Ibrahim A Albalawi, Ahmad A Abdullah, Mohammed E Mohammed
To investigate the frequency and clinical characteristics of emergency presentation of colorectal carcinoma (CRC) in Tabuk Region of Saudi Arabia.  Methods: This is a retrospective, descriptive hospital-based study. All cases with CRC that presented to the main referral hospitals in Tabuk, Saudi Arabia between 2010 and 2015 were retrieved. The relevant hospitals are: King Salman Military Hospital, King Khalid Hospital, and King Fahad Hospital.  Results: Seventy-three patients were included in the study...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28438617/tumor-budding-as-a-risk-factor-for-nodal-metastasis-in-pt1-colorectal-cancers-a-meta-analysis
#12
Rocco Cappellesso, Claudio Luchini, Nicola Veronese, Marcello Lo Mele, Erik Rosa-Rizzotto, Ennio Guido, Franca De Lazzari, Pierluigi Pilati, Fabio Farinati, Stefano Realdon, Marco Solmi, Matteo Fassan, Massimo Rugge
Worldwide, colorectal cancer (CRC) screening programs have significantly increased the detection of sub-mucosal (pT1) adenocarcinoma. Completion surgery may be indicated after endoscopic excision of these potentially metastasizing early cancers. However, the post-surgical prevalence of nodal implants does not exceed 15%, leading to questions concerning the clinical appropriateness of any post-endoscopy surgery. Eastern scientific societies (Japanese Society for Cancer of the Colon-Rectum, in particular) include tumor budding (TB), defined as the presence of isolated single cancer cells or clusters of fewer than five cancer cells at the tumor invasive front, among the variables that must be included in histological reports...
April 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28436468/higher-risk-of-colorectal-cancer-in-patients-with-newly-diagnosed-diabetes-mellitus-before-the-age-of-colorectal-cancer-screening-initiation
#13
Sander de Kort, Ad A M Masclee, Silvia Sanduleanu, Matty P Weijenberg, Myrthe P P van Herk-Sukel, Nico J J Oldenhof, Joop P W van den Bergh, Harm R Haak, Maryska L Janssen-Heijnen
Type 2 diabetes mellitus (T2DM) is associated with greater risk for colorectal cancer (CRC). The age of onset of T2DM is decreasing worldwide. An increased CRC risk in young T2DM patients could be relevant for the age at which to initiate CRC screening. We report on CRC risk in T2DM patients with attention to age of diagnosis. We used pharmacy data (from 1998 to 2010) from the PHARMO Database Network linked to the Eindhoven Cancer Registry. Multivariable time-dependent Cox regression analyses were conducted to calculate hazard ratios (HR) for developing CRC comparing T2DM with non-T2DM...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28433614/association-between-breast-cancer-and-the-risk-of-colorectal-cancer-systematic-review-and-meta-analysis
#14
REVIEW
Jennifer H Lai, Gavin Park, Lauren B Gerson
BACKGROUND: The prior literature has suggested a potential increase in colorectal cancer (CRC) among patients with breast cancer. METHODS: We performed a systematic review of the literature and included 37 retrospective cohort studies and 8 case-control studies. The primary aim was to determine the prevalence of CRC. Secondary aims included analysis of adenomatous polyps and analysis of CRC prevalence by age. We calculated pooled prevalence rates and odds ratios using random effects models with 95% confidence intervals (CI)...
April 19, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28431951/public-health-impact-of-colonoscopy-use-on-colorectal-cancer-mortality-in-germany-and-the-united-states
#15
Chen Chen, Christian Stock, Michael Hoffmeister, Hermann Brenner
BACKGROUND AND AIMS: Colonoscopy has been demonstrated to be effective in reducing colorectal cancer (CRC) incidence and mortality, and has been widely used for primary CRC screening in Germany and the United States. We performed a population-based analysis to evaluate and compare the public health impact of recent colonoscopy use on CRC deaths among adults aged 55 to 79 years in Germany and the United States from 2008 to 2011. METHODS: The epidemiologic metrics of attributable fraction and prevented fraction as well as the impact numbers were calculated using colonoscopy utilization data from nationally representative health surveys, relative risk estimates from medical literature, and CRC death registry data...
April 18, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28431245/host-microbe-co-metabolism-dictates-cancer-drug-efficacy-in-c-%C3%A2-elegans
#16
Timothy A Scott, Leonor M Quintaneiro, Povilas Norvaisas, Prudence P Lui, Matthew P Wilson, Kit-Yi Leung, Lucia Herrera-Dominguez, Sonia Sudiwala, Alberto Pessia, Peter T Clayton, Kevin Bryson, Vidya Velagapudi, Philippa B Mills, Athanasios Typas, Nicholas D E Greene, Filipe Cabreiro
Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut microbes, a known source of inter-individual variability, impacted drug efficacy. Combining two tractable genetic models, the bacterium E. coli and the nematode C. elegans, we performed three-way high-throughput screens that unraveled the complexity underlying host-microbe-drug interactions. We report that microbes can bolster or suppress the effects of fluoropyrimidines through metabolic drug interconversion involving bacterial vitamin B6, B9, and ribonucleotide metabolism...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28428902/nonfamilial-juvenile-polyposis-syndrome-with-exon-5-novel-mutation-in-smad-4-gene
#17
Amna Ahmed, Badr Alsaleem
Juvenile polyposis syndrome (JPS) is a rare autosomal dominant hereditary disorder, characterized by multiple juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer. JPS is most frequently caused by mutations in the SMAD4 or BMPR1A genes. Herein, we report a child with juvenile polyposis syndrome (JPS) with a novel mutation in the SMAD4 gene. An 8-year-old boy presented with recurrent rectal bleeding and was found to have multiple polyps in the entire colon. The histology of the resected polyps was consistent with juvenile polyps...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28428185/investments-in-cancer-research-awarded-to-uk-institutions-and-the-global-burden-of-cancer-2000-2013-a-systematic-analysis
#18
Mahiben Maruthappu, Michael G Head, Charlie D Zhou, Barnabas J Gilbert, Majd A El-Harasis, Rosalind Raine, Joseph R Fitchett, Rifat Atun
OBJECTIVES: To systematically categorise cancer research investment awarded to United Kingdom (UK) institutions in the period 2000-2013 and to estimate research investment relative to disease burden as measured by mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs). DESIGN: Systematic analysis of all open-access data. SETTING AND PARTICIPANTS: Public and philanthropic funding to all UK cancer research institutions, 2000-2013...
April 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28428142/increased-rate-of-adenoma-detection-associates-with-reduced-risk-of-colorectal-cancer-and-death
#19
M F Kaminski, P Wieszczy, M Rupinski, U Wojciechowska, J Didkowska, E Kraszewska, J Kobiela, R Franczyk, M Rupinska, B Kocot, A Chaber-Ciopinska, J Pachlewski, M Polkowski, J Regula
BACKGROUND & AIMS: Quality of endoscopists' performance of colonoscopy is measured by adenoma detection rate (ADR). Although ADR is inversely associated with interval colorectal cancer and colorectal cancer death, the effects of increasing ADR have not been demonstrated. We investigated whether increasing ADRs from individual endoscopists associates with reduced risks of interval colorectal cancer and subsequent death METHODS: We performed a prospective cohort study of individuals who underwent screening colonoscopy within the National Colorectal Cancer Screening Program in Poland, from January 1, 2004 through December 31, 2008...
April 17, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28427954/colorectal-cancer-screening-initiation-after-age-50-years-in-an-organized-program
#20
Stacey A Fedewa, Douglas A Corley, Christopher D Jensen, Wei Zhao, Michael Goodman, Ahmedin Jemal, Kevin C Ward, Theodore R Levin, Chyke A Doubeni
INTRODUCTION: Recent studies report racial disparities among individuals in organized colorectal cancer (CRC) programs; however, there is a paucity of information on CRC screening utilization by race/ethnicity among newly age-eligible adults in such programs. METHODS: This was a retrospective cohort study among Kaiser Permanente Northern California enrollees who turned age 50 years between 2007 and 2012 (N=138,799) and were served by a systemwide outreach and facilitated in-reach screening program based primarily on mailed fecal immunochemical tests to screening-eligible people...
April 17, 2017: American Journal of Preventive Medicine
keyword
keyword
118267
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"