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https://www.readbyqxmd.com/read/27893427/cholesterol-import-and-steroidogenesis-are-biosignatures-for-gastric-cancer-patient-survival
#1
Wei-Chun Chang, Shang-Fen Huang, Yang-Ming Lee, Hsueh-Chou Lai, Bi-Hua Cheng, Wei-Chung Cheng, Jason Yen-Ping Ho, Long-Bin Jeng, Wen-Lung Ma
Androgens, estrogens, progesterone and related signals are reported to be involved in the pathology of gastric cancer. However, varied conclusions exist based on serum hormone levels, receptor expressions, and in vitro or in vivo studies. This report used a web-based gene survival analyzer to evaluate biochemical processes, including cholesterol importing via lipoprotein/receptors (L/R route), steroidogenic enzymes, and steroid receptors, in gastric cancer patients prognosis. The sex hormone receptors (androgen receptor, progesterone receptor, and estrogen receptor ESR1 or ESR2), L/R route (low/high-density lipoprotein receptors, LDLR/LRP6/SR-B1 and lipoprotein lipase, LPL) and steroidogenic enzymes (CYP11A1, HSD3B1, CYP17, HSD17B1, HSD3B1, CYP19A1 and SRD5A1) were associated with 5-year survival of gastric cancer patients...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27813053/elevated-steroid-hormone-production-in-the-db-db-mouse-model-of-obesity-and-type-2-diabetes
#2
A Hofmann, M Peitzsch, C Brunssen, J Mittag, A Jannasch, A Frenzel, N F Brown, S M Weldon, G Eisenhofer, S R Bornstein, H Morawietz
Obesity and type 2 diabetes have become a major public health problem worldwide. Steroid hormone dysfunction appears to be linked to development of obesity and type 2 diabetes and correction of steroid abnormalities may offer new approaches to therapy. We therefore analyzed plasma steroids in 15-16 week old obese and diabetic db/db mice using liquid chromatography-tandem mass spectrometry. Lean db/+ served as controls. Db/db mice developed obesity, hyperglycemia, hyperleptinemia, and hyperlipidemia. Hepatic triglyceride storage was increased and adiponectin and pancreatic insulin were lowered...
November 3, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27803898/candidate-gene-expression-in-bos-indicus-ovarian-tissues-prepubertal-and-postpubertal-heifers-in-diestrus
#3
Mayara Morena Del Cambre Amaral Weller, Marina Rufino S Fortes, Laercio R Porto-Neto, Matthew Kelly, Bronwyn Venus, Lisa Kidd, João Paulo Arcelino do Rego, Sophia Edwards, Gry B Boe-Hansen, Emily Piper, Sigrid A Lehnert, Simone Eliza Facioni Guimarães, Stephen Stewart Moore
Growth factors such as bone morphogenetic proteins 6, 7, 15, and two isoforms of transforming growth factor-beta (BMP6, BMP7, BMP15, TGFB1, and TGFB2), and insulin-like growth factor system act as local regulators of ovarian follicular development. To elucidate if these factors as well as others candidate genes, such as estrogen receptor 1 (ESR1), growth differentiation factor 9 (GDF9), follicle-stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), bone morphogenetic protein receptor, type 2 (BMPR2), type 1 insulin-like growth factor receptor (IGFR1), and key steroidogenic enzymes cytochrome P450 aromatase and 3-β-hydroxysteroid dehydrogenase (CYP19A1 and HSD3B1) could modulate or influence diestrus on the onset of puberty in Brahman heifers, their ovarian mRNA expression was measured before and after puberty (luteal phase)...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27802415/genome-wide-and-gene-based-meta-analyses-identify-novel-loci-influencing-blood-pressure-response-to-hydrochlorothiazide
#4
Erika Salvi, Zhiying Wang, Federica Rizzi, Yan Gong, Caitrin W McDonough, Sandosh Padmanabhan, Timo P Hiltunen, Chiara Lanzani, Roberta Zaninello, Martina Chittani, Kent R Bailey, Antti-Pekka Sarin, Matteo Barcella, Olle Melander, Arlene B Chapman, Paolo Manunta, Kimmo K Kontula, Nicola Glorioso, Daniele Cusi, Anna F Dominiczak, Julie A Johnson, Cristina Barlassina, Eric Boerwinkle, Rhonda M Cooper-DeHoff, Stephen T Turner
This study aimed to identify novel loci influencing the antihypertensive response to hydrochlorothiazide monotherapy. A genome-wide meta-analysis of blood pressure (BP) response to hydrochlorothiazide was performed in 1739 white hypertensives from 6 clinical trials within the International Consortium for Antihypertensive Pharmacogenomics Studies, making it the largest study to date of its kind. No signals reached genome-wide significance (P<5×10(-)(8)), and the suggestive regions (P<10(-5)) were cross-validated in 2 black cohorts treated with hydrochlorothiazide...
October 31, 2016: Hypertension
https://www.readbyqxmd.com/read/27746313/progressive-effects-of-silver-nanoparticles-on-hormonal-regulation-of-reproduction-in-male-rats
#5
K Dziendzikowska, A Krawczyńska, M Oczkowski, T Królikowski, K Brzóska, A Lankoff, M Dziendzikowski, T Stępkowski, M Kruszewski, J Gromadzka-Ostrowska
The growing use of silver nanoparticles (AgNPs) in various applications, including consumer, agriculture and medicine products, has raised many concerns about the potential risks of nanoparticles (NPs) to human health and the environment. An increasing body of evidence suggests that AgNPs may have adverse effects of humans, thus the aim of this study was to investigate the effects of AgNPs on the male reproductive system. Silver particles (20nm AgNPs (groups Ag I and Ag II) and 200nm Ag sub-micron particles (SPs) (group Ag III)) were administered intravenously to male Wistar rats at a dose of 5 (groups Ag I and Ag III) or 10 (group Ag II) mg/kg of body weight...
December 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27673747/regulation-of-development-of-rat-stem-and-progenitor-leydig-cells-by-activin
#6
L Li, Y Wang, X Li, S Liu, G Wang, H Lin, Q Zhu, J Guo, H Chen, H-S Ge, R-S Ge
Stem Leydig cells have been demonstrated to differentiate into adult Leydig cells via intermediate stages of progenitor and immature Leydig cells. However, the exact regulatory mechanisms are unclear. We hypothesized that the development of stem or progenitor Leydig cells depends upon locally produced growth factors. Microarray analysis revealed that the expression levels of activin type I receptor (Acvr1) and activin A receptor type II-like 1 (Acvrl1) were stem > progenitor = immature = adult Leydig cells...
September 27, 2016: Andrology
https://www.readbyqxmd.com/read/27644933/prostate-cancer-hsd3b1-variant-confers-inferior-adt-outcomes
#7
Peter Sidaway
No abstract text is available yet for this article.
September 20, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27575027/hsd3b1-and-resistance-to-androgen-deprivation-therapy-in-prostate-cancer-a-retrospective-multicohort-study
#8
Jason W D Hearn, Ghada AbuAli, Chad A Reichard, Chandana A Reddy, Cristina Magi-Galluzzi, Kai-Hsiung Chang, Rachel Carlson, Laureano Rangel, Kevin Reagan, Brian J Davis, R Jeffrey Karnes, Manish Kohli, Donald Tindall, Eric A Klein, Nima Sharifi
BACKGROUND: HSD3B1 (1245A>C) has been mechanistically linked to castration-resistant prostate cancer because it encodes an altered enzyme that augments dihydrotestosterone synthesis from non-gonadal precursors. We postulated that men inheriting the HSD3B1 (1245C) allele would exhibit resistance to androgen-deprivation therapy (ADT). METHODS: In this multicohort study, we determined HSD3B1 genotype retrospectively in men treated with ADT for post-prostatectomy biochemical failure and correlated genotype with long-term clinical outcomes...
October 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27575026/inherited-hsd3b1-polymorphisms-and-hormonal-therapy-resistance
#9
Emmanuel S Antonarakis
No abstract text is available yet for this article.
October 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27512005/effect-of-adiponectin-on-the-steroidogenic-acute-regulatory-protein-p450-side-chain-cleavage-enzyme-and-3%C3%AE-hydroxysteroid-dehydrogenase-gene-expression-progesterone-and-androstenedione-production-by-the-porcine-uterus-during-early-pregnancy
#10
N Smolinska, K Dobrzyn, M Kiezun, K Szeszko, A Maleszka, T Kaminski
Adiponectin and its receptors are expressed in the human and porcine uterus and this endocrine system has important role in the regulation of reproductive processes. The expression of steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenase (HSD3B1) were observed in the human and porcine uterus during the oestrous cycle and pregnancy. The de novo synthesis of steroids in the uterus might be a crucial factor for effective implantation and maintenance of pregnancy. We hypothesized that adiponectin modulates the expression of key enzymes in the synthesis of the steroids: StAR, P450 side chain cleavage enzyme (CYP11A1) and HSD3B1, as well as progesterone (P4) and androstenedione (A4) secretion by the porcine uterus...
June 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27439492/clock-genes-and-salt-sensitive-hypertension-a-new-type-of-aldosterone-synthesizing-enzyme-controlled-by-the-circadian-clock-and-angiotensin-ii
#11
Hitoshi Okamura, Masao Doi, Kaoru Goto, Rika Kojima
With the current societal norm of shiftwork and long working hours, maintaining a stable daily life is becoming very difficult. An irregular lifestyle disrupts circadian rhythms, resulting in the malfunction of body physiology and ultimately leading to lifestyle-related diseases, including hypertension. By analyzing completely arrhythmic Cry1/Cry2 double-knockout (Cry-null) mice, we found salt-sensitive hypertension accompanied by hyperaldosteronism. On the basis of a DNA microarray analysis of the adrenal gland and subsequent biochemical analyses, we discovered that Hsd3b6/HSD3B1, a subtype of 3β-HSD, is markedly overexpressed in aldosterone-producing cells in the Cry-null adrenal cortex...
October 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27388148/effects-of-butylated-hydroxyanisole-on-the-steroidogenesis-of-rat-immature-leydig-cells
#12
Xiaoheng Li, Shuyan Cao, Baiping Mao, Yanfang Bai, Xiaomin Chen, Xiudi Wang, Ying Wu, Linxi Li, Han Lin, Qingquan Lian, Ping Huang, Ren-Shan Ge
Butylated hydroxyanisole (BHA) is a synthetic antioxidant used for food preservation. Whether BHA affects testosterone biosynthesis is still unclear. The effects of BHA on the steroidogenesis in rat immature Leydig cells were investigated. Rat immature Leydig cells were isolated from 35-old-day rats and cultured with BHA (50 μM) for 3 h in combination with 22R-OH-cholesterol, pregnenolone, progesterone, androstenedione, testosterone or dihydrotestosterone, and the concentrations of 5α-androstanediol and testosterone in the media were measured...
July 7, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27148549/comparison-of-the-effects-of-dibutyl-and-monobutyl-phthalates-on-the-steroidogenesis-of-rat-immature-leydig-cells
#13
Linxi Li, Xiaomin Chen, Guoxin Hu, Sicong Wang, Renai Xu, Qiqi Zhu, Xiaoheng Li, Mingcang Wang, Qing-Quan Lian, Ren-Shan Ge
Dibutyl phthalate (DBP) is a widely used synthetic phthalic diester and monobutyl phthalate (MBP) is its main metabolite. DBP can be released into the environment and potentially disrupting mammalian male reproductive endocrine system. However, the potencies of DBP and MBP to inhibit Leydig cell steroidogenesis and their possible mechanisms are not clear. Immature Leydig cells isolated from rats were cultured with 0.05-50 μM DBP or MBP for 3 h in combination with testosterone synthesis regulator or intermediate...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27128796/gossypol-inhibits-lh-induced-steroidogenesis-in-bovine-theca-cells
#14
Thet Su Myat, Masafumi Tetsuka
Gossypol, a polyphenolic aldehyde found in cottonseed, has been shown to perturb steroidogenesis in granulosa and luteal cells of rats, pigs and cattle. However, little is known about the direct effect of gossypol on theca cell functions in any species. The present study was conducted to investigate the effect of gossypol on the steroidogenesis and the expression of genes involved in it in cultured bovine theca cells. Theca cells were isolated from healthy preovulatory follicles and were cultured in the presence of luteinizing hormone (LH) for up to 7 days...
April 29, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27118706/oleic-acid-induces-specific-alterations-in-the-morphology-gene-expression-and-steroid-hormone-production-of-cultured-bovine-granulosa-cells
#15
Vengala Rao Yenuganti, Torsten Viergutz, Jens Vanselow
After parturition, one of the major problems related to nutritional management that is faced by the majority of dairy cows is negative energy balance (NEB). During NEB, excessive lipid mobilization takes place and hence the levels of free fatty acids, among them oleic acid, increase in the blood, but also in the follicular fluid. This accumulation can be associated with serious metabolic and reproductive disorders. In the present study, we analyzed the effects of physiological concentrations of oleic acid on cell morphology, apoptosis, necrosis, proliferation and steroid production, and on the abundance of selected transcripts in cultured bovine granulosa cells...
June 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27085553/expression-of-steroidogenic-enzymes-and-their-transcription-factors-in-cortisol-producing-adrenocortical-adenomas-immunohistochemical-analysis-and-quantitative-real-time-polymerase-chain-reaction-studies
#16
Fumie Kubota-Nakayama, Yasuhiro Nakamura, Sachiko Konosu-Fukaya, Abdullah Azmahani, Kazue Ise, Yuto Yamazaki, Yuko Kitawaki, Saulo J A Felizola, Yoshikiyo Ono, Kei Omata, Ryo Morimoto, Noriyuki Iwama, Fumitoshi Satoh, Hironobu Sasano
Adrenal Cushing syndrome (CS) is caused by the overproduction of cortisol in adrenocortical tumors including adrenal cortisol-producing adenoma (CPA). In CS, steroidogenic enzymes such as 17α-hydroxylase/17, 20-lase (CYP17A1), 3β-hydroxysteroid dehydrogenase (HSD3B), and 11β-hydroxylase (CYP11B1) are abundantly expressed in tumor cells. In addition, several transcriptional factors have been reported to play pivotal roles in the regulation of these enzymes in CPA, but their correlations with those enzymes above have still remained largely unknown...
August 2016: Human Pathology
https://www.readbyqxmd.com/read/27067917/structure-activity-relationships-of-phthalates-in-inhibition-of-human-placental-3%C3%AE-hydroxysteroid-dehydrogenase-1-and-aromatase
#17
Ren-Ai Xu, Baiping Mao, Senlin Li, Jianpeng Liu, Xiaojun Li, Huitao Li, Ying Su, Guoxin Hu, Qing-Quan Lian, Ren-Shan Ge
Phthalates are associated with preterm delivery. However, the mechanism is unclear. Progesterone formed by 3β-hydroxysteroid dehydrogenase 1 (HSD3B1) and estradiol by aromatase (CYP19A1) in placenta are critical for maintaining pregnancy. In this study, we compared structure-activity relationships (SAR) of 14 phthalates varied in carbon atoms in alcohol moiety to inhibit human HSD3B1 in COS1 and CYP19A1 in JEG-3 cells. There were responses in that only diphthalates with 4-7 carbon atoms were competitive HSD3B1 inhibitors and diphthalates with 6 carbon atoms were CYP19A1 inhibitors...
June 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/26995740/mcl1-is-a-key-regulator-of-steroidogenesis-in-mouse-leydig-cells
#18
Li Guang-Yu, Lan Hai-Yan, Liang Ji-Hong, Mo Yun-Cong, Deng Xue-Lian, Lin Chun-Yu, Su Wen-Yong
Myeloid cell leukemia-1 (MCL1), an anti-apoptotic member of the BCL2 family, is expressed abundantly in the testis. Previous characterization revealed that MCL1 is expressed exclusively in the Leydig cells in the mouse testis, yet what it does in these cells remains unknown. We therefore analyzed testosterone biosynthesis in isolated primary Leydig cells and the MA-10 cell line, in which MCL1 was knocked down using an siRNA strategy. The mRNA abundance of the steroidogenic genes Star, Cyp11a1, Cyp17a1, Hsd3b1, Srd5a, and the luteinizing hormone/choriogonadotropin receptor Lhcgr were significantly reduced following MCL1 knockdown...
March 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/26940100/molecular-determinants-of-a-competent-bovine-corpus-luteum-first-vs-final-wave-dominant-follicles
#19
E Gregson, R Webb, E L Sheldrick, B K Campbell, G E Mann, S Liddell, K D Sinclair
Reproductive management in cattle requires the synchrony of follicle development and oestrus before insemination. However, ovulation of follicles that have not undergone normal physiological maturation can lead to suboptimal luteal function. Here, we investigated the expression of a targeted set of 47 genes in (a) a first-wave vs final-wave dominant follicle (DF; the latter destined to ovulate spontaneously) and (b) 6-day-old corpora lutea (CLs) following either spontaneous ovulation or induced ovulation of a first-wave DF to ascertain their functional significance for competent CL development...
June 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/26907321/effects-of-in-utero-exposure-to-dicyclohexyl-phthalate-on-rat-fetal-leydig-cells
#20
Xiaoheng Li, Xiaomin Chen, Guoxin Hu, Linxi Li, Huina Su, Yiyan Wang, Dongxin Chen, Qiqi Zhu, Chao Li, Junwei Li, Mingcang Wang, Qingquan Lian, Ren-Shan Ge
Dicyclohexyl phthalate (DCHP) is one of the phthalate plasticizers. The objective of the present study was to investigate the effects of DCHP on fetal Leydig cell distribution and function as well as testis development. Female pregnant Sprague Dawley dams orally received vehicle (corn oil, control) or DCHP (10, 100, and 500 mg/kg/day) from gestational day (GD) 12 to GD 21. At GD 21.5, testicular testosterone production, fetal Leydig cell number and distribution, testicular gene and protein expression levels were examined...
March 2016: International Journal of Environmental Research and Public Health
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