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arterial hypertension microcirculation

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https://www.readbyqxmd.com/read/29145709/defining-a-unified-vascular-phenotype-in-systemic-sclerosis
#1
REVIEW
Yannick Allanore, Oliver Distler, Marco Matucci-Cerinic, Christopher P Denton
Microcirculation impairment and related vasculopathy is a hallmark of systemic sclerosis. Digital ulcers are second only to Raynaud's phenomenon as a vascular complication occurring in scleroderma patients. Digital ulcers are painful and generate disability. Furthermore, patients may develop recurrent digital ulcers and one may ask whether the outcomes of such patients might be different to those of unaffected ones. Recently several registries have provided relevant information about digital ulcers. Male sex and severe skin disease seem to be the main associated factors observed in several registries...
November 16, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29135307/correlation-between-flicker-induced-retinal-vessel-vasodilatation-and-plasma-biomarkers-of-endothelial-dysfunction-in-hypertensive-patients
#2
Machalińska Anna, Pius-Sadowska Ewa, Babiak Katarzyna, Sałacka Anna, Safranow Krzysztof, Kawa Miłosz Piotr, Machaliński Bogusław
PURPOSE: Hypertension (HT) strongly affects the vascular endothelium, resulting in chronic inflammatory disease. Dynamic vessel analysis (DVA) is a modern methodological approach to analyze vascular function in the retinal microcirculation. The aim of this study was to examine whether a defective retinal vessels response is associated with HT-induced endothelial dysfunction. MATERIALS AND METHODS: Retinal vessel reactions to flicker stimulation were examined by DVA in both eyes of 37 hypertensive and 41 healthy control subjects...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29131886/determinant-factors-for-arterial-hemodynamics-in-hypertension-theoretical-insights-from-a-computational-model-based-study
#3
Fuyou Liang, Debao Guan, Jordi Alastruey
Hypertension is a well-documented predictive factor for cardiovascular events. Clinical studies have extensively demonstrated the differential hemodynamic consequences of various anti-hypertensive drugs, but failed to clearly elucidate the underlying mechanisms due to the difficulty in performing a quantitative deterministic analysis based on clinical data that carry confounding information stemming from inter-patient differences and the nonlinearity of cardiovascular hemodynamics. In the present study, a multi-scale model of the cardiovascular system was developed to quantitatively investigate the relationships between hemodynamic variables and cardiovascular properties under hypertensive conditions, aiming to establish a theoretical basis for assisting in the interpretation of clinical observations or optimization of therapy...
November 13, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29057671/retinal-vascular-resistance-in-arterial-hypertension
#4
Dennis Kannenkeril, Joanna M Harazny, Agnes Bosch, Christian Ott, Georg Michelson, Roland E Schmieder, Stefanie Friedrich
PURPOSE: Retinal microcirculation represents an easily accessible, non-invasive, in-vivo possibility to assess early microvascular changes. In addition to the assessment of functional (e.g. retinal capillary flow, RCF) and retinal arteriolar structural parameters (e.g. wall-to-lumen-ratio, WLR) we now suggest a new parameter reflecting the resistance in small retinal arterioles (RVR). MATERIAL AND METHODS: In 45 normotensive (NT) subjects and 123 patients with hypertension stage 1 (HT) we assessed RCF, WLR, arteriolar diameter, lumen diameter and wall cross section area in the retinal circulation by using scanning laser Doppler flowmetry (SLDF)...
October 23, 2017: Blood Pressure
https://www.readbyqxmd.com/read/29044853/regulation-of-voltage-gated-potassium-channels-in-vascular-smooth-muscle-during-hypertension-and-metabolic-disorders
#5
Madeline Nieves-Cintrón, Arsalan U Syed, Matthew A Nystoriak, Manuel F Navedo
Voltage-gated potassium (KV ) channels are key regulators of vascular smooth muscle contractility and vascular tone, and thus have major influence on the microcirculation. KV channels are important determinants of vascular smooth muscle membrane potential (Em ). A number of KV subunits are expressed in the plasma membrane of smooth muscle cells. Each subunit confers distinct kinetics and regulatory properties that allow for fine control of Em to orchestrate vascular tone. Modifications in KV subunit expression and/or channel activity can contribute to changes in vascular smooth muscle contractility in response to different stimuli and in diverse pathological conditions...
October 16, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29024896/identification-of-a-soluble-guanylate-cyclase-in-rbcs-preserved-activity-in-patients-with-coronary-artery-disease
#6
Miriam M Cortese-Krott, Evanthia Mergia, Christian M Kramer, Wiebke Lückstädt, Jiangning Yang, Georg Wolff, Christina Panknin, Thilo Bracht, Barbara Sitek, John Pernow, Johannes-Peter Stasch, Martin Feelisch, Doris Koesling, Malte Kelm
Endothelial dysfunction is associated with decreased NO bioavailability and impaired activation of the NO receptor soluble guanylate cyclase (sGC) in the vasculature and in platelets. Red blood cells (RBCs) are known to produce NO under hypoxic and normoxic conditions; however evidence of expression and/or activity of sGC and downstream signaling pathway including phopshodiesterase (PDE)-5 and protein kinase G (PKG) in RBCs is still controversial. In the present study, we aimed to investigate whether RBCs carry a functional sGC signaling pathway and to address whether this pathway is compromised in coronary artery disease (CAD)...
September 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/28974571/endothelial-mineralocorticoid-receptor-mediates-parenchymal-arteriole-and-posterior-cerebral-artery-remodeling-during-angiotensin-ii-induced-hypertension
#7
Janice M Diaz-Otero, Courtney Fisher, Kelsey Downs, M Elizabeth Moss, Iris Z Jaffe, William F Jackson, Anne M Dorrance
The brain is highly susceptible to injury caused by hypertension because the increased blood pressure causes artery remodeling that can limit cerebral perfusion. Mineralocorticoid receptor (MR) antagonism prevents hypertensive cerebral artery remodeling, but the vascular cell types involved have not been defined. In the periphery, the endothelial MR mediates hypertension-induced vascular injury, but cerebral and peripheral arteries are anatomically distinct; thus, these findings cannot be extrapolated to the brain...
December 2017: Hypertension
https://www.readbyqxmd.com/read/28816352/pulmonary-artery-wave-propagation-and-reservoir-function-in-conscious-man-impact-of-pulmonary-vascular-disease-respiration-and-dynamic-stress-tests
#8
Junjing Su, Charlotte Manisty, Ulf Simonsen, Luke S Howard, Kim H Parker, Alun D Hughes
KEY POINTS: Wave travel plays an important role in cardiovascular physiology. However, many aspects of pulmonary arterial wave behaviour remain unclear. Wave intensity and reservoir-excess pressure analyses were applied in the pulmonary artery in subjects with and without pulmonary hypertension during spontaneous respiration and dynamic stress tests. Arterial wave energy decreased during expiration and Valsalva manoeuvre due to decreased ventricular preload. Wave energy also decreased during handgrip exercise due to increased heart rate...
October 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28805757/-the-influence-of-cytoflavin-therapy-on-the-cerebral-hemodynamics-in-patients-with-various-stages-of-hypertensive-disease
#9
L A Belova, V V Mashin, O Yu Kolotik-Kameneva, N V Belova, A Scuderi, P L Antignani
AIM: To study an influence of cytoflavin therapy on the cerebral hemodynamics in patients with various stages of hypertensive disease (HD). MATERIAL AND METHODS: One hundred and forty patients with HD, I-III stages, were randomized into 2 groups: patients of group 1 received complex treatment (antihypertensive therapy and cytoflavin), patients of group 2 were treated with antihypertensive therapy. The control group consisted of 30 healthy people. The changes in cerebral hemodynamics using the algorithm of the complex ultrasound study of cerebral vascular system were assessed...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28717584/pulse-wave-analysis-with-diffusing-wave-spectroscopy
#10
Markus Belau, Wolfgang Scheffer, Georg Maret
Hypertension is a major risk factor for cardiovascular disease and thus at the origin of many deaths by e.g. heart attack or stroke. Hypertension is caused by many factors including an increase in arterial stiffness which leads to changes in pulse wave velocity and wave reflections. Those often result in an increased left ventricular load which may result in heart failure as well as an increased pulsatile pressure in the microcirculation l to damage to blood vessels. In order to specifically treat the different causes of hypertension it is desirable to perform a pulse wave analysis as a complement to measurements of systolic and diastolic pressure by brachial cuff sphygmomanometry...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28700893/coronary-microvascular-disease-as-an-early-culprit-in-the-pathophysiology-of-diabetes-and-metabolic-syndrome
#11
REVIEW
Hicham Labazi, Aaron J Trask
Metabolic syndrome (MetS) is a group of cardio-metabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia; these are also a combination of independent coronary artery disease (CAD) risk factors. Alarmingly, the prevalence of MetS risk factors are increasing and a leading cause for mortality. In the vasculature, complications from MetS and type 2 diabetes (T2D) can be divided into microvascular (retinopathy and nephropathy) and macrovascular (cardiovascular diseases and erectile dysfunction)...
September 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28660179/monitoring-cerebral-and-renal-oxygenation-status-during-neonatal-digestive-surgeries-using-near-infrared-spectroscopy
#12
Jonathan Beck, Gauthier Loron, Claire Masson, Marie-Laurence Poli-Merol, Eliane Guyot, Camille Guillot, Nathalie Bednarek, Caroline François
BACKGROUND: Depending on the initial pathology, hypovolemia, intra-abdominal hypertension, and sepsis are often encountered in neonatal digestive surgery. Accurate newborn monitoring during and after surgery is essential to adapt resuscitation protocols. Near infrared spectroscopy (NIRS) is non-invasive and can detect hypoperfusion which indicates a low circulatory blood flow, regardless of the cause. OBJECTIVE: Evaluating changes in cerebral and renal regional oxygen saturation during neonatal digestive surgeries, conducted according to normal practices, with commonly used monitoring parameters...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28619664/nailfold-capillaroscopic-changes-in-patients-with-idiopathic-pulmonary-arterial-hypertension-and-systemic-sclerosis-related-pulmonary-arterial-hypertension
#13
A Corrado, M Correale, N Mansueto, I Monaco, A Carriero, A Mele, R Colia, M Di Biase, F P Cantatore
Pulmonary arterial hypertension (PAH) represents one of the main clinical expressions of the vascular changes in systemic sclerosis (SSc). Lung microvascular changes can play a role in the pathogenesis of idiopathic PAH (IPAH) also. The aim of this study is to investigate the presence of capillaroscopic abnormalities in patients with IPAH and to evaluate the differences in capillary nailfold changes between patients with IPAH and patients with SSc with and without PAH. METHODS: 39 SSc patients (19 with PAH - SSc-PAH and 20 without - SSc-noPAH), 21 subjects with IPAH and 20 healthy subjects were recruited...
June 12, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28585358/muscle-microcirculation-alterations-and-relation-to-dipping-status-in-newly-diagnosed-untreated-patients-with-arterial-hypertension-a-pilot-study
#14
Georgios Tzanis, Stavros Dimopoulos, Chris Manetos, Eleni Koroboki, Efstathios Manios, Ioannis Vasileiadis, Nikolaos Zakopoulos, Serafim Nanas
OBJECTIVE: The importance of abnormalities observed in the microcirculation of patients with arterial hypertension (AH) is being increasingly recognized. The authors aimed to evaluate skeletal muscle microcirculation in untreated, newly diagnosed hypertensive patients with Near Infrared Spectroscopy (NIRS), a non-invasive method that evaluates microcirculation. METHODS: We evaluated 34 subjects, 17 patients with AH (13 males, 49±13y, BMI: 26±2 kg/m(2) ) and 17 healthy controls (12 males, 49±15y, BMI: 25±3 kg/m(2) )...
June 5, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28577102/dihydroquercetin-improves-microvascularization-and-microcirculation-in-the-brain-cortex-of-shr-rats-during-the-development-of-arterial-hypertension
#15
M B Plotnikov, O I Aliev, A V Sidekhmenova, A Yu Shamanaev, A M Anishchenko, T I Fomina, G A Chernysheva, V I Smol'yakova, A M Arkhipov
The effects of dihydroquercetin (50 mg/kg intragastrically daily for 6 weeks) on the density of capillary network (mean number of capillaries per mm(2)), mean capillary diameter, structure of capillary network, capillary diameter distribution (<3, 3-5, 5-7, and 7-9 μ), and local cerebral blood flow (by laser Doppler) in the visual cortex were studied in SHR rats during the development of arterial hypertension (from the 6th to the 12th week of life). Normally, the systolic and diastolic BP progressively increased in SHR rats during this period...
June 3, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28572599/comparisons-of-microvascular-and-macrovascular-changes-in-aldosteronism-related-hypertension-and-essential-hypertension
#16
Monica Varano, Pierluigi Iacono, Massimiliano M Tedeschi, Claudio Letizia, Mario Curione, Claudio Savoriti, Erika Baiocco, Laura Zinnamosca, Cristiano Marinelli, Barbara Boccassini, Mariacristina Parravano
Case-control observational study to evaluate the microvascular and macrovascular changes in patients with hypertension secondary to primary aldosteronism (PA), essential hypertension (EH) and healthy subjects. Measurements of arterial stiffness including augmentation index (AIx) and pulse wave velocity (PWV) were assessed using a TensioClinic arteriograph system. Retinal microcirculation was imaged by a Retinal Vessel Analyzer (RVA) and a non-midriatic camera (Topcon-TRC-NV2000). IMEDOS software analyzed the retinal artery diameter (RAD), retinal vein diameters (RVD) and arteriole-to-venule ratio (AVR) of the vessels coming off the optic disc...
June 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28509668/norepinephrine-in-septic-shock-when-and-how-much
#17
Olfa Hamzaoui, Thomas W L Scheeren, Jean-Louis Teboul
PURPOSE OF REVIEW: Norepinephrine is the first-line agent recommended during resuscitation of septic shock to correct hypotension due to depressed vascular tone. Important clinical issues are the best timing to start norepinephrine, the optimal blood pressure target, and the best therapeutic options to face refractory hypotension when high doses of norepinephrine are required to reach the target. RECENT FINDINGS: Recent literature has reported benefits of early administration of norepinephrine because of the following reasons: profound and durable hypotension is an independent factor of increased mortality, early administration of norepinephrine increases cardiac output, improves microcirculation and avoids fluid overload...
August 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28482625/transepidermal-oxygen-flux-during-arterial-occlusion-using-ratiometric-luminescence-imaging
#18
M Ranieri, S Klein, A Kotrade, C Taeger, J D Dolderer, L Prantl, S Geis
BACKGROUND: A physiological oxygen transport through a circulatory and microcirculatory system is essential for execution of cellular functions. Several pathological conditions e.g. infections, ischemia, cancer, diabetes, hypertension or chronic wounds show a change of oxygen distribution and oxygen tension in cellular microenvironment. Additionally complex operative procedures in order to reconstruct tissue defects require a reliable monitoring of microcirculation. OBJECTIVE: Target of this study was to evaluate skin oxygenation during an ischemia-reperfusion experiment using transepidermal oxygen flux imaging...
May 2, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28431922/microvascular-injury-and-the-kidney-in-hypertension
#19
G Ruiz-Hurtado, L M Ruilope
Renal macrocirculation participates in the development of arterial hypertension. The elevation in systemic blood pressure (BP) can damage the kidney starting in the microcirculation. Established arterial hypertension impinge upon the large arteries and stiffness develops. As a consequence central BP raises and BP pulsatility appear and contribute to further damage renal microcirculation by direct transmission of the elevated BP.
April 18, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/28412915/early-functional-and-structural-microvascular-changes-in-hypertension-related-to-aging
#20
Roger de Moraes, Eduardo Tibirica
It is becoming increasingly clear that both microvascular network alterations and subsequent tissue perfusion defects may precede and predict the development of arterial hypertension and other cardiovascular and metabolic diseases, including diabetes and metabolic syndrome. Moreover, the subsequent functional and structural alterations in microvascular reactivity and density, as well as alterations in the macrocirculation characteristic of physiologic vascular aging, contribute to the development of target organ damage...
April 12, 2017: Current Hypertension Reviews
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