keyword
https://read.qxmd.com/read/38528674/balancing-feeling-prepared-without-feeling-devoured-a-qualitative-study-of-self-care-from-the-perspective-of-self-empowered-persons-living-with-parkinson-s-disease-in-sweden
#21
JOURNAL ARTICLE
Jamie L Luckhaus, Anna Clareborn, Maria Hägglund, Sara Riggare
INTRODUCTION: Parkinson's Disease (PD) is a complex neurodegenerative disease resulting in a wide range of motor and nonmotor symptoms for which the treatment regimen is often complex. People with Parkinson's (PwP) spend time daily on self-care practices including self-tracking signs and symptoms or seeking disease-specific knowledge. Research suggests self-care interventions yield promising care and health outputs for PwP, yet most research focuses on the provider perspective rather than that of those conducting the self-care...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/38528673/fluctuating-salience-in-those-living-with-genetic-risk-of-motor-neuron-disease-a-qualitative-interview-study
#22
JOURNAL ARTICLE
Jade Howard, Fadhila Mazanderani, Karen Forrest Keenan, Martin R Turner, Louise Locock
BACKGROUND: Motor neuron disease (MND) (also known as amyotrophic lateral sclerosis) is a life-limiting neurodegenerative condition. In up to 20% of people with MND, a pathogenic variant associated with autosomal dominant inheritance can be identified. Children of people carrying a pathogenic variant have a 50% chance of inheriting this and a higher, although harder to predict, chance of developing the disease compared to the general adult population. This paper explores the experience of living with the genetic risk of MND...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/38528661/using-focus-groups-to-inform-a-peer-health-navigator-service-for-people-who-are-transgender-and-gender-diverse-in-saskatchewan-canada
#23
JOURNAL ARTICLE
Gwen Rose, Michelle McCarron, Mel Reid, T Fayant-McLeod, Emily Gulka, James Young, Megan Clark, Stéphanie J Madill
BACKGROUND: This study investigated healthcare access and quality for people who are transgender and gender-diverse (PTGD) in Saskatchewan (SK), Canada, to inform a larger project that was piloting two peer health navigators for PTGD. METHODS: Two online focus groups were held. Nineteen participants were recruited to represent a broad range in age, gender and location in SK. Transcripts of the focus groups were analyzed using a thematic approach. RESULTS: The core theme that was identified was participants' desire for culturally safe healthcare...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/38528631/head-and-neck-cancer-of-unknown-primary-unveiling-primary-tumor-sites-through-machine-learning-on-dna-methylation-profiles
#24
JOURNAL ARTICLE
Leonhard Stark, Atsuko Kasajima, Fabian Stögbauer, Benedikt Schmidl, Jakob Rinecker, Katharina Holzmann, Sarah Färber, Nicole Pfarr, Katja Steiger, Barbara Wollenberg, Jürgen Ruland, Christof Winter, Markus Wirth
BACKGROUND: The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most common histologic subtype, squamous cell carcinoma, can stem from various tumor primary sites, including the oral cavity, oropharynx, larynx, head and neck skin, lungs, and esophagus. DNA methylation profiles are highly tissue-specific and have been successfully used to classify tissue origin...
March 25, 2024: Clinical Epigenetics
https://read.qxmd.com/read/38528550/recovery-pattern-after-decompression-of-central-lumbar-spinal-stenosis-a-prospective-observational-cohort-study
#25
JOURNAL ARTICLE
Niyaz Hareni, Soheil Ebrahimnia, Björn E Rosengren, Magnus K Karlsson
BACKGROUND: Detailed preoperative information is associated with superior outcomes. We aimed to describe the recovery pattern after decompression of central lumbar spinal stenosis (CLSS). METHODS: 50 patients aged 51-85 years who underwent decompression without fusion due to CLSS were followed from before to after surgery (post-op day 1, 7, and 14). Back and leg pain were evaluated using the Numeric Rating Scale (NRS; 0 = no pain 0, 10 = worst pain) and quality of life using the EuroQol-5D index (0 = death, 1 = best), and EQ-5D-visual analogue scale (VAS; 0 = worst, 100 = best)...
March 25, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38528545/the-chronically-ill-in-the-labour-market-are-they-hierarchically-sorted-by-education
#26
JOURNAL ARTICLE
M Kamrul Islam, Egil Kjerstad, Håvard Thorsen Rydland
BACKGROUND: The chronically ill as a group has on average lower probability of employment compared to the general population, a situation that has persisted over time in many countries. Previous studies have shown that the prevalence of chronic diseases is higher among those with lower levels of education. We aim to quantify the double burden of low education and chronic illness comparing the differential probabilities of employment between the chronically ill with lower, medium, and high levels of education and how their employment rates develop over time...
March 25, 2024: International Journal for Equity in Health
https://read.qxmd.com/read/38528456/roar-a-re-optimization-based-online-adaptive-radiotherapy-of-anal-cancer-a-prospective-phase-ii-trial-protocol
#27
JOURNAL ARTICLE
Katrine Smedegaard Storm, Lina M Åström, Patrik Sibolt, Claus P Behrens, Gitte F Persson, Eva Serup-Hansen
BACKGROUND: Chemo-radiotherapy with curative intent for anal cancer has high complete remission rates, but acute treatment-related gastrointestinal (GI) toxicity is significant. Toxicity occurs due to irradiation of surrounding normal tissue. Current radiotherapy requires the addition of large planning margins to the radiation field to ensure target coverage regardless of the considerable organ motion in the pelvic region. This increases the irradiated volume and radiation dose to the surrounding normal tissue and thereby toxicity...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38528312/a-canadian-simulation-model-for-major-depressive-disorder-study-protocol
#28
REVIEW
Shahzad Ghanbarian, Gavin W K Wong, Mary Bunka, Louisa Edwards, Sonya Cressman, Tania Conte, Sandra Peterson, Rohit Vijh, Morgan Price, Christian Schuetz, David Erickson, Linda Riches, Ginny Landry, Kim McGrail, Jehannine Austin, Stirling Bryan
BACKGROUND: Major depressive disorder (MDD) is a common, often recurrent condition and a significant driver of healthcare costs. People with MDD often receive pharmacological therapy as the first-line treatment, but the majority of people require more than one medication trial to find one that relieves symptoms without causing intolerable side effects. There is an acute need for more effective interventions to improve patients' remission and quality of life and reduce the condition's economic burden on the healthcare system...
March 26, 2024: PharmacoEconomics Open
https://read.qxmd.com/read/38528040/unexpected-identification-of-obesity-associated-mutations-in-lep-and-mc4r-genes-in-patients-with-anorexia-nervosa
#29
JOURNAL ARTICLE
Luisa Sophie Rajcsanyi, Yiran Zheng, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stephan Zipfel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Jochen Antel, Pamela Fischer-Posovszky, Johannes Hebebrand, Anke Hinney
Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (MC4R) gene predispose to a lower BMI. In individuals with reduced body weight, we thus expected mutations leading to an enhanced function in the respective genes, like leptin (LEP) and MC4R. Therefore, we have Sanger sequenced the coding regions of LEP and MC4R in 462 female patients with anorexia nervosa (AN), and 445 healthy-lean controls...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527835/-clinical-analysis-of-14-patients-aged-%C3%A2-50-years-with-high-risk-multiple-myeloma-treated-with-allogeneic-hematopoietic-stem-cell-transplantation
#30
JOURNAL ARTICLE
P Pan, J L Wang, W H Zhai, Q L Ma, D L Yang, S Z Feng, M Z Han, A M Pang, E L Jiang
Objective: To evaluate the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in young patients with high-risk multiple myeloma (HRMM) and analyzed the factors affecting patient prognosis. Methods: In this retrospective study, we analyzed the clinical data of 14 patients with HRMM with cytogenetic abnormalities or high-risk biological factors who underwent allo-HSCT at the Hematopoietic Stem Cell Transplantation Center of the Institute of Hematology & Blood Diseases Hospital between November 2016 and November 2022...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527820/challenges-addressing-lung-cancer-screening-for-patients-with-multimorbidity-in-primary-care-a-qualitative-study
#31
JOURNAL ARTICLE
Minal S Kale, Orly Morgan, Juan Wisnivesky, Julie Schnur, Michael A Diefenbach
PURPOSE: Many individuals who are eligible for lung cancer screening have comorbid conditions complicating their shared decision-making conversations with physicians. The goal of our study was to better understand how primary care physicians (PCPs) factor comorbidities into their evaluation of the risks and benefits of lung cancer screening and into their shared decision-making conversations with patients. METHODS: We conducted semistructured interviews by videoconference with 15 PCPs to assess the extent of shared decision-making practices and explore their understanding of the intersection of comorbidities and lung cancer screening, and how that understanding informed their clinical approach to this population...
2024: Annals of Family Medicine
https://read.qxmd.com/read/38527813/-it-can-t-hurt-why-many-patients-with-limited-life-expectancy-decide-to-accept-lung-cancer-screening
#32
JOURNAL ARTICLE
Eduardo R Núñez, Rendelle E Bolton, Jacqueline H Boudreau, Samantha K Sliwinski, Abigail N Herbst, Lauren E Kearney, Tanner J Caverly, Renda Soylemez Wiener
PURPOSE: Lung cancer screening (LCS) has less benefit and greater potential for iatrogenic harm among people with multiple comorbidities and limited life expectancy. Yet, such individuals are more likely to undergo screening than healthier LCS-eligible people. We sought to understand how patients with marginal LCS benefit conceptualize their health and make decisions regarding LCS. METHODS: We interviewed 40 people with multimorbidity and limited life expectancy, as determined by high Care Assessment Need scores, which predict 1-year risk of hospitalization or death...
2024: Annals of Family Medicine
https://read.qxmd.com/read/38527621/electrodiagnostic-severity-does-not-predict-short-to-mid-term-outcomes-of-cubital-tunnel-release-surgery
#33
JOURNAL ARTICLE
Nicholas Pohl, Parker Brush, Meghan Foos, Samuel Alfonsi, Pedro Beredjiklian, Daniel Fletcher
HYPOTHESIS: This study aimed to explore the prognostic value of electrodiagnostic studies (EDS) to clarify their utility in clinical practice prior to cubital tunnel release surgery as well as identify patient factors associated with patient-reported functional improvement after surgery. Our hypothesis is that patients with severe preoperative findings on EDS will tend to experience less functional improvement after surgery given the extent of ulnar nerve compressive injury. METHODS: Patients with cubital tunnel syndrome and preoperative electrodiagnostic data treated from 2012-2022 with cubital tunnel release were assessed regarding demographic information, preoperative physical exam findings, EDS findings, postoperative complications, and patient-reported outcomes...
March 23, 2024: Journal of Shoulder and Elbow Surgery
https://read.qxmd.com/read/38527417/in-epas-we-trust-is-quality-and-safety-a-must-a-cross-specialty-analysis-of-entrustable-professional-activity-guides
#34
JOURNAL ARTICLE
Allison Brown, Julie La, McNiel-Inyani Keri, Chris Hillis, Saleem Razack, Nadine Korah, Jolanta Karpinski, Jason R Frank, Brian Wong, Joanne Goldman
PURPOSE: The inclusion of quality improvement (QI) and patient safety (PS) into CanMEDS reflects an expectation that graduating physicians are competent in these areas upon training completion. To ensure that Canadian postgraduate specialty training achieves this, the translation of QI/PS competencies into training standards as part of the implementation of competency-based medical education requires special attention. METHODS: We conducted a cross-specialty, multi-method analysis to examine how QI/PS was incorporated into the EPA Guides across 11 postgraduate specialties in Canada...
March 25, 2024: Medical Teacher
https://read.qxmd.com/read/38527343/shifts-in-reduction-mammaplasty-surgical-volumes-with-the-emergence-of-a-global-pandemic
#35
JOURNAL ARTICLE
Pearl Shah, Yelissa Navarro, Kometh Thawanyarat, Robert Moody, Asim Ahmed, John Collar, Kathryne Holmes, Jack Yu
INTRODUCTION: The onset of the COVID-19 pandemic resulted in significant changes to the surgical caseload for various surgery departments across the United States. As medical institutions prioritized resources for the expected increase in patient volumes due to the SARS-CoV-2 viral infection, surgical departments saw a decrease in nonemergent and elective surgical procedures. Reduction mammoplasties, which are largely covered by insurance, are among the elective procedures that provide significant revenue to the hospital...
April 1, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38527298/artificial-intelligence-based-video-monitoring-of-movement-disorders-in-the-elderly-a-review-on-current-and-future-landscapes
#36
JOURNAL ARTICLE
Kye Won Park, Maryam S Mirian, Martin J McKeown
Due to global ageing, the burden of chronic movement and neurological disorders (Parkinson's disease and essential tremor) is rapidly increasing. Current diagnosis and monitoring of these disorders rely largely on face-to-face assessments utilising clinical rating scales, which are semi-subjective and time-consuming. To address these challenges, the utilisation of artificial intelligence (AI) has emerged. This review explores the advantages and challenges associated with using AI-driven video monitoring to care for elderly patients with movement disorders...
March 1, 2024: Singapore Medical Journal
https://read.qxmd.com/read/38527181/associations-between-therapists-verbal-techniques-and-patient-rated-therapeutic-alliance-insight-and-problem-solving
#37
JOURNAL ARTICLE
Antje Gumz, Anne Daubmann, Rainer Erices, Jelka Berger, Laurence Reuter, Denise Kästner
OBJECTIVE: To investigate associations between common factors (alliance, insight, problem solving) and therapists' techniques. We expected a positive association between (1) supportive techniques and the alliance, (2) interpretative techniques and insight, and (3) a stronger association between interpretative techniques and insight for patients with more severe baseline symptoms. Other associations were analyzed in an exploratory way. METHOD: Sixty sessions from 15 adult female patients diagnosed with personality disorder were analyzed using the Psychodynamic Interventions List (verbal techniques, observer-rated transcripts), and the Session Questionnaire for General and Differential Individual Psychotherapy (common factors, patient-rated after each session)...
March 25, 2024: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://read.qxmd.com/read/38527149/radial-versus-femoral-access-for-mechanical-thrombectomy-in-patients-with-stroke-a-noninferiority-randomized-clinical-trial
#38
JOURNAL ARTICLE
David Hernandez, Manuel Requena, Marta Olivé-Gadea, Marta de Dios, Laura Ludovica Gramegna, Marian Muchada, Álvaro García-Tornel, Francesco Diana, Federica Rizzo, Eila Rivera, Marta Rubiera, Carlos Piñana, Marc Rodrigo-Gisbert, David Rodríguez-Luna, Jorge Pagola, Tomás Carmona, Jesús Juega, Noelia Rodríguez-Villatoro, Carlos Molina, Marc Ribo, Alejandro Tomasello
BACKGROUND: Transfemoral access is predominantly used for mechanical thrombectomy in patients with stroke with a large vessel occlusion. Following the interventional cardiology guidelines, routine transradial access has been proposed as an alternative, although its safety and efficacy remain controversial. We aim to explore the noninferiority of radial access in terms of final recanalization. METHODS: The study was an investigator-initiated, single-center, evaluator-blinded, noninferiority randomized clinical trial...
April 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38526776/effectiveness-of-using-a-self-directed-learning-program-to-teach-physical-examination-and-health-assessment-skills-a-quasi-experimental-study
#39
JOURNAL ARTICLE
Shiah-Lian Chen, I-Chen Liao
BACKGROUND: Conducting health assessments and physical examinations are essential skills for independent practice. Exploring how to teach these skills effectively is essential. PURPOSE: This study was designed to validate the effectiveness of a self-directed learning program in improving nursing student outcomes in terms of their learning health assessment and physical examination skills. METHOD: A quasi-experimental design was used, and second-year nursing students enrolled in a health assessment and physical examination course at a university of science and technology in central Taiwan were recruited using purposive sampling...
April 1, 2024: Journal of Nursing Research: JNR
https://read.qxmd.com/read/38526607/the-efficacy-and-safety-of-pd-1-inhibitor-combined-with-tace-in-the-first-line-treatment-of-unresectable-hepatocellular-carcinoma
#40
JOURNAL ARTICLE
Qing-Qing Liu, Xiang-Xu Wang, Hongchen Ji, Qiong-Yi Dou, Hong-Mei Zhang
The application of immune checkpoint inhibitors (ICIs) has changed the treatment of advanced hepatocellular carcinoma. Transcatheter arterial chemoembolization (TACE) is a first-line treatment for intermediate hepatocellular carcinoma. Serving as a local treatment modality that can induce immunogenic cell death, the efficacy and safety of combined use with ICI have not been evaluated. Although there have been prospective studies aimed at evaluating the efficacy and safety of ICI combined with TACE in BCLC stage B HCC patients, there are few reports on the evaluation of BCLC stage C patients with distant metastasis or portal vein cancer thrombus...
March 25, 2024: Medical Oncology
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