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https://www.readbyqxmd.com/read/27850265/626-multidrug-resistant-organism-sepsis-in-pediatric-liver-transplant-recipients-a-burgeoning-problem
#1
Alicia Alcamo, Lauren Alessi, S Noona Vehovic, Diana Pang, Geoffrey Bond, Joseph Carcillo, Marian Michaels, Raj Aneja
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27833082/discovery-and-replication-of-micrornas-for-breast-cancer-risk-using-genome-wide-profiling
#2
Cenny Taslim, Daniel Y Weng, Theodore M Brasky, Ramona G Dumitrescu, Kun Huang, Bhaskar V S Kallakury, Shiva Krishnan, Adana A Llanos, Catalin Marian, Joseph McElroy, Sallie S Schneider, Scott L Spear, Melissa A Troester, Jo L Freudenheim, Susan Geyer, Peter G Shields
BACKGROUND: Genome-wide miRNA expression may be useful for predicting breast cancer risk and/or for the early detection of breast cancer. RESULTS: A 41-miRNA model distinguished breast cancer risk in the discovery study (accuracy of 83.3%), which was replicated in the independent study (accuracy = 63.4%, P=0.09). Among the 41 miRNA, 20 miRNAs were detectable in serum, and predicted breast cancer occurrence within 18 months of blood draw (accuracy 53%, P=0.06). These risk-related miRNAs were enriched for HER-2 and estrogen-dependent breast cancer signaling...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27790103/a-voxel-based-morphometry-study-reveals-local-brain-structural-alterations-associated-with-ambient-fine-particles-in-older-women
#3
Ramon Casanova, Xinhui Wang, Jeanette Reyes, Yasuyuki Akita, Marc L Serre, William Vizuete, Helena C Chui, Ira Driscoll, Susan M Resnick, Mark A Espeland, Jiu-Chiuan Chen, Sylvia Wassertheil-Smoller, Mimi Goodwin, Richard DeNise, Michael Lipton, James Hannigan, Anthony Carpini, David Noble, Wilton Guzman, Jane Morley Kotchen, Joseph Goveas, Diana Kerwin, John Ulmer, Steve Censky, Troy Flinton, Tracy Matusewic, Robert Prost, Marcia L Stefanick, Sue Swope, Anne Marie Sawyer-Glover, Susan Hartley, Rebecca Jackson, Rose Hallarn, Bonnie Kennedy, Jill Bolognone, Lindsay Casimir, Amanda Kochis, John Robbins, Sophia Zaragoza, Cameron Carter, John Ryan, Denise Macias, Jerry Sonico, Lauren Nathan, Barbara Voigt, Pablo Villablanca, Glen Nyborg, Sergio Godinez, Adele Perrymann, Marian Limacher, Sheila Anderson, Mary Ellen Toombs, Jeffrey Bennett, Kevin Jones, Sandy Brum, Shane Chatfield, Kevin Vantrees, Jennifer Robinson, Candy Wilson, Kevin Koch, Suzette Hart, Jennifer Carroll, Mary Cherrico, Judith Ockene, Linda Churchill, Douglas Fellows, Anthony Serio, Sharon Jackson, Deidre Spavich, Karen Margolis, Cindy Bjerk, Chip Truwitt, Margaret Peitso, Alexa Camcrena, Richard Grim, Julie Levin, Mary Perron, Robert Brunner, Ross Golding, Leslie Pansky, Sandie Arguello, Jane Hammons, Nikki Peterson, Carol Murphy, Maggie Morgan, Mauricio Castillo, Thomas Beckman, Benjamin Huang, Lewis Kuller, Pat McHugh, Carolyn Meltzer, Denise Davis, Joyce Davis, Piera Kost, Kim Lucas, Tom Potter, Lee Tarr, Sally Shumaker, Mark Espeland, Laura Coker, Jeff Williamson, Debbie Felton, LeeAnn Gleiser, Steve Rapp, Claudine Legault, Maggie Dailey, Ramon Casanova, Julia Robertson, Patricia Hogan, Sarah Gaussoin, Pam Nance, Cheryl Summerville, Ricardo Peral, Josh Tan, Nick Bryan, Christos Davatzikos, Lisa Desiderio, Neil Buckholtz, Susan Molchan, Susan Resnick, Jacques Rossouw, Linda Pottern
Objective: Exposure to ambient fine particulate matter (PM2.5: PM with aerodynamic diameters < 2.5 μm) has been linked with cognitive deficits in older adults. Using fine-grained voxel-wise analyses, we examined whether PM2.5 exposure also affects brain structure. Methods: Brain MRI data were obtained from 1365 women (aged 71-89) in the Women's Health Initiative Memory Study and local brain volumes were estimated using RAVENS (regional analysis of volumes in normalized space). Based on geocoded residential locations and air monitoring data from the U...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27529831/ground-state-chemical-reactivity-under-vibrational-coupling-to-the-vacuum-electromagnetic-field
#4
Anoop Thomas, Jino George, Atef Shalabney, Marian Dryzhakov, Sreejith J Varma, Joseph Moran, Thibault Chervy, Xiaolan Zhong, Eloïse Devaux, Cyriaque Genet, James A Hutchison, Thomas W Ebbesen
The ground-state deprotection of a simple alkynylsilane is studied under vibrational strong coupling to the zero-point fluctuations, or vacuum electromagnetic field, of a resonant IR microfluidic cavity. The reaction rate decreased by a factor of up to 5.5 when the Si-C vibrational stretching modes of the reactant were strongly coupled. The relative change in the reaction rate under strong coupling depends on the Rabi splitting energy. Product analysis by GC-MS confirmed the kinetic results. Temperature dependence shows that the activation enthalpy and entropy change significantly, suggesting that the transition state is modified from an associative to a dissociative type...
September 12, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27467575/open-source-drug-discovery-with-the-malaria-box-compound-collection-for-neglected-diseases-and-beyond
#5
Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V Avery, Vicky M Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E Boucher, Fabrice F Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L Colon, Daisy D Colón-López, Yolanda Corbett, Gregory J Crowther, Noemi Cowan, Sarah D'Alessandro, Na Le Dang, Michael Delves, Joseph L DeRisi, Alan Y Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T Ferdig, José A Fernández Robledo, David A Fidock, Isabelle Florent, Patrick V T Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M Goldgof, Rajarshi Guha, W Armand Guiguemde, Nil Gural, R Kiplin Guy, Michael A E Hansen, Kirsten K Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T Jensen, Rays H Y Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P Kumar, Dennis E Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N Mfopa, Raj N Misra, Seunghyun Moon, John P Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J Quinn, Christopher A Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J Sullivan, William Sullivan, Sundari Suresh, Brian M Suzuki, Yo Suzuki, S Joshua Swamidass, Donatella Taramelli, Lauve R Y Tchokouaha, Anjo Theron, David Thomas, Kathryn F Tonissen, Simon Townson, Abhai K Tripathi, Valentin Trofimov, Kenneth O Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M Vinetz, Phat Voong Vinh, Hoan Vu, Nao-Aki Watanabe, Kate Weatherby, Pamela M White, Andrew F Wilks, Elizabeth A Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H A Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A Willis
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery...
July 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27462649/potent-spinal-parenchymal-aav9-mediated-gene-delivery-by-subpial-injection-in-adult-rats-and-pigs
#6
Atsushi Miyanohara, Kota Kamizato, Stefan Juhas, Jana Juhasova, Michael Navarro, Silvia Marsala, Nada Lukacova, Marian Hruska-Plochan, Erik Curtis, Brandon Gabel, Joseph Ciacci, Eric T Ahrens, Brian K Kaspar, Don Cleveland, Martin Marsala
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult animals using delivery routes with the most clinical relevance (intravenous or intrathecal). Here, we demonstrate that the spinal pia membrane represents the primary barrier limiting effective AAV9 penetration into the spinal parenchyma after intrathecal AAV9 delivery...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27315459/fkbp5-interacts-with-maltreatment-in-children-with-extreme-pervasive-and-persistent-aggression
#7
Lyubov Bryushkova, Clement Zai, Sheng Chen, Irene Pappa, Viara Mileva, Henning Tiemeier, Marian Bakermans-Kranenburg, James L Kennedy, Joseph H Beitchman
Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours...
August 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27289259/molybdenum-cofactor-and-isolated-sulphite-oxidase-deficiencies-clinical-and-molecular-spectrum-among-egyptian-patients
#8
Maha S Zaki, Laila Selim, Hala T El-Bassyouni, Mahmoud Y Issa, Iman Mahmoud, Samira Ismail, Mariane Girgis, Abdelrahim A Sadek, Joseph G Gleeson, Mohamed S Abdel Hamid
AIM: Molybdenum cofactor deficiency (MoCD) and Sulfite oxidase deficiency (SOD) are rare autosomal recessive conditions of sulfur-containing amino acid metabolism with overlapping clinical features and emerging therapies. The clinical phenotype is indistinguishable and they can only be differentiated biochemically. MOCS1, MOCS2, MOCS3, and GPRN genes contribute to the synthesis of molybdenum cofactor, and SUOX gene encodes sulfite oxidase. The aim of this study was to elucidate the clinical, radiological, biochemical and molecular findings in patients with SOD and MoCD...
December 0: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27213958/imidazopyridine-and-pyrazolopiperidine-derivatives-as-novel-inhibitors-of-serine-palmitoyl-transferase
#9
Michael J Genin, Isabel C Gonzalez Valcarcel, William G Holloway, Jason Lamar, Marian Mosior, Eric Hawkins, Thomas Estridge, Jeffrey Weidner, Thomas Seng, David Yurek, Lisa A Adams, Jennifer Weller, Vincent L Reynolds, Joseph T Brozinick
To develop novel treatments for type 2 diabetes and dyslipidemia, we pursued inhibitors of serine palmitoyl transferase (SPT). To this end compounds 1 and 2 were developed as potent SPT inhibitors in vitro. 1 and 2 reduce plasma ceramides in rodents, have a slight trend toward enhanced insulin sensitization in DIO mice, and reduce triglycerides and raise HDL in cholesterol/cholic acid fed rats. Unfortunately these molecules cause a gastric enteropathy after chronic dosing in rats.
June 23, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26921328/a-meta-analysis-of-individual-participant-data-reveals-an-association-between-circulating-levels-of-igf-i-and-prostate-cancer-risk
#10
Ruth C Travis, Paul N Appleby, Richard M Martin, Jeff M P Holly, Demetrius Albanes, Amanda Black, H Bas Bueno-de-Mesquita, June M Chan, Chu Chen, Maria-Dolores Chirlaque, Michael B Cook, Mélanie Deschasaux, Jenny L Donovan, Luigi Ferrucci, Pilar Galan, Graham G Giles, Edward L Giovannucci, Marc J Gunter, Laurel A Habel, Freddie C Hamdy, Kathy J Helzlsouer, Serge Hercberg, Robert N Hoover, Joseph A M J L Janssen, Rudolf Kaaks, Tatsuhiko Kubo, Loic Le Marchand, E Jeffrey Metter, Kazuya Mikami, Joan K Morris, David E Neal, Marian L Neuhouser, Kotaro Ozasa, Domenico Palli, Elizabeth A Platz, Michael N Pollak, Alison J Price, Monique J Roobol, Catherine Schaefer, Jeannette M Schenk, Gianluca Severi, Meir J Stampfer, Pär Stattin, Akiko Tamakoshi, Catherine M Tangen, Mathilde Touvier, Nicholas J Wald, Noel S Weiss, Regina G Ziegler, Timothy J Key, Naomi E Allen
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte...
April 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/26905920/antipsychotic-polypharmacy-and-augmentation-strategies-prior-to-clozapine-initiation-a-historical-cohort-study-of-310-adults-with-treatment-resistant-schizophrenic-disorders
#11
Joseph V Thompson, Joanne M Clark, Sophie E Legge, Giouliana Kadra, Johnny Downs, James Tr Walters, Marian L Hamshere, Richard D Hayes, David Taylor, James H MacCabe
RATIONALE: Antipsychotic polypharmacy (APP) is commonly used in schizophrenia despite a lack of robust evidence for efficacy, as well as evidence of increased rates of adverse drug reactions and mortality. OBJECTIVES: We sought to examine APP and the use of other adjunctive medications in patients with treatment-resistant schizophrenic disorders (ICD-10 diagnoses F20-F29) immediately prior to clozapine initiation, and to investigate clinical and sociodemographic factors associated with APP use in this setting...
May 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/26767891/fast-assembly-of-gold-nanoparticles-in-large-area-2d-nanogrids-using-a-one-step-near-infrared-radiation-assisted-evaporation-process
#12
André Utgenannt, Ross Maspero, Andrea Fortini, Rebecca Turner, Marian Florescu, Christopher Jeynes, Antonios G Kanaras, Otto L Muskens, Richard P Sear, Joseph L Keddie
When fabricating photonic crystals from suspensions in volatile liquids using the horizontal deposition method, the conventional approach is to evaporate slowly to increase the time for particles to settle in an ordered, periodic close-packed structure. Here, we show that the greatest ordering of 10 nm aqueous gold nanoparticles (AuNPs) in a template of larger spherical polymer particles (mean diameter of 338 nm) is achieved with very fast water evaporation rates obtained with near-infrared radiative heating...
February 23, 2016: ACS Nano
https://www.readbyqxmd.com/read/26685770/cyclophosphamide-conditioning-in-patients-with-severe-aplastic-anaemia-given-unrelated-marrow-transplantation-a-phase-1-2-dose-de-escalation-study
#13
Paolo Anderlini, Juan Wu, Iris Gersten, Marian Ewell, Jakob Tolar, Joseph H Antin, Roberta Adams, Sally Arai, Gretchen Eames, Mitchell E Horwitz, John McCarty, Ryotaro Nakamura, Michael A Pulsipher, Scott Rowley, Eric Leifer, Shelly L Carter, Nancy L DiFronzo, Mary M Horowitz, Dennis Confer, H Joachim Deeg, Mary Eapen
BACKGROUND: The optimum preparative regimen for unrelated donor marrow transplantation in patients with severe aplastic anaemia remains to be established. We investigated whether the combination of fludarabine, anti-thymocyte globulin, and total body irradiation (TBI) would enable reduction of the cyclophosphamide dose to less than 200 mg/kg while maintaining engraftment and having a survival similar to or better than that with standard regimens using a cyclophosphamide dose of 200 mg/kg (known to be associated with significant organ toxicity) for unrelated donor transplantation for severe aplastic anaemia...
September 2015: Lancet Haematology
https://www.readbyqxmd.com/read/26387267/european-court-of-human-rights-echr-2015-6-case-of-marian-chiri%C3%A5-%C3%A4-v-romania-21-october-2014-no-9443-10-third-section
#14
Joseph Dute
No abstract text is available yet for this article.
March 2015: European Journal of Health Law
https://www.readbyqxmd.com/read/26240283/differential-effects-of-hepatocyte-nuclear-factor-4%C3%AE-isoforms-on-tumor-growth-and-t-cell-factor-4-ap-1-interactions-in-human-colorectal-cancer-cells
#15
COMPARATIVE STUDY
Linh M Vuong, Karthikeyani Chellappa, Joseph M Dhahbi, Jonathan R Deans, Bin Fang, Eugene Bolotin, Nina V Titova, Nate P Hoverter, Stephen R Spindler, Marian L Waterman, Frances M Sladek
The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) is tumor suppressive in the liver but amplified in colon cancer, suggesting that it also might be oncogenic. To investigate whether this discrepancy is due to different HNF4α isoforms derived from its two promoters (P1 and P2), we generated Tet-On-inducible human colon cancer (HCT116) cell lines that express either the P1-driven (HNF4α2) or P2-driven (HNF4α8) isoform and analyzed them for tumor growth and global changes in gene expression (transcriptome sequencing [RNA-seq] and chromatin immunoprecipitation sequencing [ChIP-seq])...
October 2015: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/26224837/key-bioactive-reaction-products-of-the-no-h2s-interaction-are-s-n-hybrid-species-polysulfides-and-nitroxyl
#16
Miriam M Cortese-Krott, Gunter G C Kuhnle, Alex Dyson, Bernadette O Fernandez, Marian Grman, Jenna F DuMond, Mark P Barrow, George McLeod, Hidehiko Nakagawa, Karol Ondrias, Péter Nagy, S Bruce King, Joseph E Saavedra, Larry K Keefer, Mervyn Singer, Malte Kelm, Anthony R Butler, Martin Feelisch
Experimental evidence suggests that nitric oxide (NO) and hydrogen sulfide (H2S) signaling pathways are intimately intertwined, with mutual attenuation or potentiation of biological responses in the cardiovascular system and elsewhere. The chemical basis of this interaction is elusive. Moreover, polysulfides recently emerged as potential mediators of H2S/sulfide signaling, but their biosynthesis and relationship to NO remain enigmatic. We sought to characterize the nature, chemical biology, and bioactivity of key reaction products formed in the NO/sulfide system...
August 25, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26196521/nitro-assisted-br%C3%A3-nsted-acid-catalysis-application-to-a-challenging-catalytic-azidation
#17
Marian Dryzhakov, Malik Hellal, Eléna Wolf, Florian C Falk, Joseph Moran
A cocatalytic effect of nitro compounds is described for the B(C6F5)3·H2O catalyzed azidation of tertiary aliphatic alcohols, enabling catalyst turnover for the first time and with a broad range of substrates. Kinetic investigations into this surprising effect reveal that nitro compounds induce a switch from first order concentration dependence in Brønsted acid to second order concentration dependence in Brønsted acid and second order dependence in the nitro compounds. Kinetic, electronic, and spectroscopic evidence suggests that higher order hydrogen-bonded aggregates of nitro compounds and acids are the kinetically competent Brønsted acid catalysts...
August 5, 2015: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/26133630/a-data-mining-framework-for-large-scale-analysis-of-dose-outcome-relationships-in-a-database-of-irradiated-head-and-neck-cancer-patients
#18
Scott P Robertson, Harry Quon, Ana P Kiess, Joseph A Moore, Wuyang Yang, Zhi Cheng, Sarah Afonso, Mysha Allen, Marian Richardson, Amanda Choflet, Andrew Sharabi, Todd R McNutt
PURPOSE: To develop a hypothesis-generating framework for automatic extraction of dose-outcome relationships from an in-house, analytic oncology database. METHODS: Dose-volume histograms (DVH) and clinical outcomes have been routinely stored to the authors' database for 684 head and neck cancer patients treated from 2007 to 2014. Database queries were developed to extract outcomes that had been assessed for at least 100 patients, as well as DVH curves for organs-at-risk (OAR) that were contoured for at least 100 patients...
July 2015: Medical Physics
https://www.readbyqxmd.com/read/26121746/glucocorticoid-receptor-antagonism-decreases-alcohol-seeking-in-alcohol-dependent-individuals
#19
RANDOMIZED CONTROLLED TRIAL
Leandro F Vendruscolo, David Estey, Vivian Goodell, Lauren G Macshane, Marian L Logrip, Joel E Schlosburg, M Adrienne McGinn, Eva R Zamora-Martinez, Joseph K Belanoff, Hazel J Hunt, Pietro P Sanna, Olivier George, George F Koob, Scott Edwards, Barbara J Mason
Alcoholism, or alcohol use disorder, is a major public health concern that is a considerable risk factor for morbidity and disability; therefore, effective treatments are urgently needed. Here, we demonstrated that the glucocorticoid receptor (GR) antagonist mifepristone reduces alcohol intake in alcohol-dependent rats but not in nondependent animals. Both systemic delivery and direct administration into the central nucleus of the amygdala, a critical stress-related brain region, were sufficient to reduce alcohol consumption in dependent animals...
August 3, 2015: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26000397/the-effects-of-particle-shape-and-size-on-t2-relaxation-in-magnetic-resonance-imaging
#20
Joseph N York, Christopher Albanese, Olga Rodriguez, Yi-Chien Le, Marian Ackun-Farmmer, Edward Van Keuren
Superparamagnetic iron oxide nanoparticles have recently been developed as T2 contrast agents for magnetic resonance imaging. Here we report the dependence of the phase relaxivity, r2, on the particle shape. We show that the size dependence of the relaxivity for spherical particles can be generalized to spheroidal particles. In addition, we show that the saturation of relaxivity above a certain size observed in spherical particles does not occur in the spheroidal particles investigated.
November 2014: Journal of Biomedical Nanotechnology
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