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https://www.readbyqxmd.com/read/27792999/genetic-variant-in-visfatin-gene-promoter-contributes-to-reduced-risk-of-hepatocellular-carcinoma-in-a-chinese-population
#1
Zhitong Wu, Yifan Sun, Yiyong Huang, Shengbo Zhu, Yi Feng, Huifen Ye, Chunming Liu, Shifu Tang
Knowledge on the role of gene variants in the visfatin promoter region in the hepatitis B virus (HBV)-related liver diseases is limited. In this study, we genotyped two potentially functional single nucleotide polymorphisms (SNPs) in the visfatin promoter region, -1535C>T (rs61330082) and -3187G>A (rs11977021), in 120 HBV-related chronic hepatitis B (CHB) patients, 140 HBV-related liver cirrhosis (HBV-LC) patients, 243 HBV-related hepatocellular carcinoma (HBV-HCC) patients, and 224 asymptomatic HBV carriers...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27729742/increased-atg5-atg12-in-hepatitis-b-virus-associated-hepatocellular-carcinoma-and-their-role-in-apoptosis
#2
Areerat Kunanopparat, Ingorn Kimkong, Tanapat Palaga, Pisit Tangkijvanich, Boonchoo Sirichindakul, Nattiya Hirankarn
AIM: To investigate autophagy-related genes, particularly ATG12, in apoptosis and cell cycle in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) and non-HBV-HCC cell lines. METHODS: The expression of autophagy-related genes in HBV-associated hepatocellular carcinoma and non-HBV-HCC cell lines and human liver tissues was examined by quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) and western blotting. The silencing of target genes was used to examine the function of various genes in apoptosis and cell cycle progression...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27725462/recognition-of-infection-status-of-outpatient-treatment-and-treatment-history-before-carcinogenesis-in-patients-with-viral-hepatitis-associated-liver-cancer
#3
Michihiko Shibata, Sota Minami, Shinji Oe, Koichiro Miyagawa, Yuichi Honma, Ryo Onitsuka, Michio Senju, Masaaki Hiura, Riko Harada, Shintaro Abe, Akinari Tabaru, Masaru Harada
We conducted a survey on the recognition of infection, status of outpatient treatment, and treatment history in hepatitis virus-associated hepatocellular carcinoma patients admitted to our department between 2005 and 2014. We compared these parameters in 75 patients with primary hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) and 307 patients with hepatitis C virus-associated hepatocellular carcinoma (HCV-HCC). Based on the presence or absence of outpatient treatment in medical institutions at the time of HCC diagnosis, the patients were divided into an outpatient treatment-free group or an outpatient treated group...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27708241/hepatitis-b-virus-x-induces-inflammation-and-cancer-in-mice-liver-through-dysregulation-of-cytoskeletal-remodeling-and-lipid-metabolism
#4
Zhongwei Xu, Linghui Zhai, Tailong Yi, Huiying Gao, Fengxu Fan, Yanchang Li, Youliang Wang, Ning Li, Xiaohua Xing, Na Su, Feilin Wu, Lei Chang, Xiuli Chen, Erhei Dai, Chao Zhao, Xiao Yang, Chunping Cui, Ping Xu
Hepatitis B virus X protein (HBx) participates in the occurrence and development processes of hepatocellular carcinoma (HCC) as a multifunctional regulation factor. However, the underlying molecular mechanism remains obscure. Here, we describe the use of p21HBx/+ mouse and SILAM (Stable Isotope Labeling in Mammals) strategy to define the pathological mechanisms for the occurrence and development of HBx induced liver cancer. We systematically compared a series of proteome samples from regular mice, 12- and 24-month old p21HBx/+ mice representing the inflammation and HCC stages of liver disease respectively and their nontransgenic wild-type (WT) littermates...
September 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27662665/metavir-and-fib-4-scores-are-associated-with-patient-prognosis-after-curative-hepatectomy-in-hepatitis-b-virus-related-hepatocellular-carcinoma-a-retrospective-cohort-study-at-two-centers-in-china
#5
Rui Liao, Yi-Peng Fu, Ting Wang, Zhi-Gang Deng, De-Wei Li, Jia Fan, Jian Zhou, Gen-Sheng Feng, Shuang-Jian Qiu, Cheng-You Du
Although Metavir and Fibrosis-4 (FIB-4) scores are typically used to assess the severity of liver fibrosis, the relationship between these scores and patient outcome in hepatocellular carcinoma (HCC) is unclear. The aim of this study was to evaluate the prognostic value of the severity of hepatic fibrosis in HBV-related HCC patients after curative resection. We examined the prognostic roles of the Metavir and preoperative FIB-4 scores in 432 HBV-HCC patients who underwent curative resection at two different medical centers located in western (Chongqing) and eastern (Shanghai) China...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27547000/prediction-and-prophylaxis-of-hepatocellular-carcinoma-occurrence-and-postoperative-recurrence-in-chronic-hepatitis-b-virus-infected-subjects
#6
Yan Du, Xue Han, Yi-Bo Ding, Jian-Hua Yin, Guang-Wen Cao
Hepatocellular carcinoma (HCC) is one of the most common and highly fatal malignancies worldwide. Chronic infection with hepatitis B virus (HBV) is a major cause of HCC. High HBV replication rate and related non-resolving inflammation are the major risk factors of HCC occurrence and postoperative recurrence. Early prophylactic options are effective in reducing HCC occurrence and improving survival. Therefore, it is important to identify HBV-infected patients who are at a higher risk of developing HCC and HBV-HCC patients who are more likely to relapse after surgery, thus providing them with more precise prophylactic strategies...
August 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27537392/impact-of-non-neoplastic-vs-intratumoural-hepatitis-b-viral-dna-and-replication-on-hepatocellular-carcinoma-recurrence
#7
Qin Wang, Luan Lin, Seungyeul Yoo, Wenhui Wang, Sima Blank, M Isabel Fiel, Hena Kadri, Wei Luan, Leslie Warren, Jun Zhu, Spiros P Hiotis
BACKGROUND: This study aims to determine the impact of intracellular hepatitis B virus (HBV) DNA, covalently closed circular DNA (cccDNA) and viral replicative activity in both tumour and non-neoplastic liver on prognosis and to determine the relationship of viral replicative activity and Ishak fibrosis in predicting outcome following resection. METHODS: A total of 99 prospectively enrolled patients treated with primary liver resection for HBV-HCC are included. Intracellular HBV DNA and cccDNA were quantitated by real-time PCR...
September 27, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27495026/hbv-is-a-risk-factor-for-poor-patient-prognosis-after-curative-resection-of-hepatocellular-carcinoma-a-retrospective-case-control-study
#8
Zhonghu Li, Xin Zhao, Peng Jiang, Senlin Xiao, Guo Wu, Kai Chen, Xi Zhang, Hui Liu, Xiuguo Han, Shuguang Wang, Xiaowu Li
Controversy exists regarding pathological factors affecting the prognosis of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV-HCC). Their postoperative clinical behaviors and the exact HBV Deoxyribonucleic Acid (DNA) thresholds that distinguish good and poor prognoses are unknown. This study aimed to compare clinicopathological, pre- and postoperative clinical factors and overall and recurrence-free survival (RFS) between HBV-HCC patients and nonhepatitis B and nonhepatitis C HCC (NBC-HCC) patients to determine the optimal prognostic HBV DNA threshold...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27402267/tagln2-a-novel-regulator-involved-in-hepatitis-b-virus-transcription-and-replication
#9
Youjia Yu, Zhiliang He, Yong Cao, Hong Tang, Feijun Huang
Hepatitis B virus (HBV) infection is one of the major health problems in the world. Transgelin-2 (TAGLN2) expression has been revealed to be significantly altered in previous studies concerning HBV-host interaction. The present study investigated TAGLN2 expression patterns in HBV related hepatocellular carcinoma (HCC) tissues and its role in HBV transcription and replication. We collected 59 HBV related HCC tissue samples, their adjacent non-tumoral tissues and 16 normal livers to make the tissue microarray...
September 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27248055/comparison-of-genome-scale-dna-methylation-profiles-in-hepatocellular-carcinoma-by-viral-status
#10
Min-Ae Song, Sandi A Kwee, Maarit Tiirikainen, Brenda Y Hernandez, Gordon Okimoto, Naoky C Tsai, Linda L Wong, Herbert Yu
Hepatocellular carcinoma (HCC) incidence has steadily increased in the US over the past 30 years. Our understanding of epigenetic regulation in HCC is still limited, especially the impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on aberrant DNA methylation. We performed genome-wide DNA methylation profiling in 33 fresh frozen tumor samples, including 10 HBV-HCC, 13 HCV-HCC, and 10 non-infected (NIV-HCC) using the Illumina HumanMethylation450 BeadChip. Gene expression profiling was also performed using the Illumina whole-genome DASL HT Assay...
June 2, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27228506/progressive-accumulation-of-mutations-in-the-hepatitis-b-virus-genome-and-its-impact-on-time-to-diagnosis-of-hepatocellular-carcinoma
#11
Feng-Yu Sung, Chia-Ying Lan, Chi-Jung Huang, Chih-Lin Lin, Chun-Jen Liu, Pei-Jer Chen, Shi-Ming Lin, Ming-Whei Yu
UNLABELLED: To evaluate how hepatitis B virus (HBV) genetic variation affected progression from chronic carrier state to hepatocellular carcinoma (HCC), we analyzed HBV full-length sequences in blood obtained <1-20 years before diagnosis from 117 HCC cases and 118 controls nested in a cohort of 4,841 HBV carriers, for whom HBV genotypes B and C are predominant. The relationship between each viral single-nucleotide polymorphism (SNP) and HCC development was assessed using ordinal logistic models according to five periods of time to diagnosis (TTD)...
September 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27216119/quantitative-proteomics-analysis-of-tissue-interstitial-fluid-for-identification-of-novel-serum-candidate-diagnostic-marker-for-hepatocellular-carcinoma
#12
Wei Sun, Baocai Xing, Lihai Guo, Zhilei Liu, Jinsong Mu, Longqin Sun, Handong Wei, Xiaohang Zhao, Xiaohong Qian, Ying Jiang, Fuchu He
Hepatocellular carcinoma (HCC) is the fifth most common malignant cancer in the world. The sensitivity of alpha-fetoprotein (AFP) is still inadequate for HCC diagnosis. Tissue interstitial fluid (TIF), as the liquid microenvironment of cancer cells, was used for biomarker discovery in this study. Paired tumor and nontumor TIF samples from 6 HBV-HCC patients were analyzed by a proteomic technique named iTRAQ (isobaric tag for relative and absolute quantitation). Totally, 241 up-regulated proteins (ratio ≥ 1...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27182163/expression-of-b7-h4-and-hepatitis-b-virus-x-in-hepatitis-b-virus-related-hepatocellular-carcinoma
#13
Bo Hong, Yun Qian, Hong Zhang, Yi-Wen Sang, Lin-Fang Cheng, Qi Wang, Song Gao, Min Zheng, Hang-Ping Yao
AIM: To investigate the expression and clinical significance of B7-H4 and hepatitis B virus X (HBx) protein in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). METHODS: The expression of B7-H4 in the human HCC cell lines HepG2 and HepG2.2.15 were detected by western blot, flow cytometry, and immunofluorescence. The expression of B7-H4 and HBx in 83 HBV-HCC was detected by immunohistochemistry, and the relationship with clinicopathological features was analyzed...
May 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27152955/differential-expression-of-plasma-mir-125b-in-hepatitis-b-virus-related-liver-diseases-and-diagnostic-potential-for-hepatitis-b-virus-induced-hepatocellular-carcinoma
#14
Shanshan Chen, Hao Chen, Shanshan Gao, Shili Qiu, Hu Zhou, Mingxia Yu, Jiancheng Tu
AIM: Acting as tumor suppressor, miR-125b shows aberrant low expression in HCC, and researches found that the dysregulation have a close relation with hepatitis B virus (HBV) infection. Here, we investigated the expression profile of this miRNA in plasma of healthy subjects and patients with chronic HBV-related liver diseases in order to confirm the feasibility of this circulating miRNA as a differential diagnostic biomarker for HBV-induced hepatocellular carcinoma (HBV-HCC). METHODS: A total of 242 individuals were enrolled in this study...
May 6, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/26989657/clinical-characteristics-of-patients-with-cryptogenic-hepatocellular-carcinoma-in-a-hepatitis-b-virus-endemic-area
#15
Hee-Won Kwak, Joong-Won Park, Young Hwan Koh, Ju Hee Lee, Ami Yu, Byung-Ho Nam
OBJECTIVES: Chronic hepatitis B virus (HBV) infection is the most common cause of hepatocellular carcinoma (HCC) in South Korea, but a high prevalence of metabolic diseases may result in increases in the incidence of cryptogenic HCC (cHCC). We studied characteristics of the cHCC in a single-center cohort. METHODS: A cohort of 1,784 HCC patients newly diagnosed and treated at the National Cancer Center, Korea, between 2004 and 2009 was reviewed and analyzed. RESULTS: The cause of HCC was categorized as cHCC, HBV, hepatitis C virus (HCV), or alcohol...
February 2016: Liver Cancer
https://www.readbyqxmd.com/read/26919045/inflammation-promotes-expression-of-stemness-related-properties-in-hbv-related-hepatocellular-carcinoma
#16
Te-Sheng Chang, Chi-Long Chen, Yu-Chih Wu, Jun-Jen Liu, Yung Che Kuo, Kam-Fai Lee, Sin-Yi Lin, Sey-En Lin, Shui-Yi Tung, Liang-Mou Kuo, Ying-Huang Tsai, Yen-Hua Huang
The expression of cancer stemness is believed to reduce the efficacy of current therapies against hepatocellular carcinoma (HCC). Understanding of the stemness-regulating signaling pathways incurred by a specific etiology can facilitate the development of novel targets for individualized therapy against HCC. Niche environments, such as virus-induced inflammation, may play a crucial role. However, the mechanisms linking inflammation and stemness expression in HCC remain unclear. Here we demonstrated the distinct role of inflammatory mediators in expressions of stemness-related properties involving the pluripotent octamer-binding transcription factor 4 (OCT4) in cell migration and drug resistance of hepatitis B virus-related HCC (HBV-HCC)...
2016: PloS One
https://www.readbyqxmd.com/read/26837720/distinct-set-of-chromosomal-aberrations-in-childhood-hepatocellular-carcinoma-is-correlated-to-hepatitis-b-virus-infection
#17
Lu Tan, Tatiana Meier, Mareike Kuhlmann, Feng Xie, Claas Baier, Zhen Zhu, Wen-Ming Cong, Ludwig Wilkens
Hepatocellular carcinoma (HCC) is rarely observed in children and adolescents, but it is reported to be correlated with hepatitis B virus (HBV+) infections. This correlation is not easily explained, because in adults, HBV infections lead to the development of HCC only after decades, not within a few years. In HBV+ adulthood HCC, distinct chromosomal imbalances have been observed. Similar analyses have not been reported for childhood HCC. Here, we investigated whether chromosomal changes were associated with childhood HCC...
March 2016: Cancer Genetics
https://www.readbyqxmd.com/read/26760979/overexpression-of-apobec3f-in-tumor-tissues-is-potentially-predictive-for-poor-recurrence-free-survival-from-hbv-related-hepatocellular-carcinoma
#18
Zongguo Yang, Liping Zhuang, Yuan Yu, Weili Zhou, Yunfei Lu, Qingnian Xu, Bozong Tang, Xiaorong Chen
UNLABELLED: The relationship between members of APOBEC3 in tumor tissues and hepatocellular carcinoma prognosis was not well studied. We compared APOBEC3 expression between tumor and non-tumor tissues based on the expression profile GSE14520 from Gene Expression Omnibus (GEO), and correlated APOBEC3 in tumor tissues with outcomes of HCC patients. APOBEC3B, which was significantly up-regulated in HCC tumor tissues (P < 0.001), was negatively associated with HCC overall survival by Cox regression (HR = 1...
December 2015: Discovery Medicine
https://www.readbyqxmd.com/read/26756996/hepatic-mir-126-is-a-potential-plasma-biomarker-for-detection-of-hepatitis-b-virus-infected-hepatocellular-carcinoma
#19
Amit Ghosh, Alip Ghosh, Somenath Datta, Debanjali Dasgupta, Soumyajit Das, Sukanta Ray, Subash Gupta, Simanti Datta, Abhijit Chowdhury, Raghunath Chatterjee, Saroj Kant Mohapatra, Soma Banerjee
Controversies about the origin of circulating miRNAs have encouraged us to identify organ specific circulating miRNAs as disease biomarkers. To identify liver-specific miRNAs for hepatocellular carcinoma (HCC), global expression profiling of miRNAs in liver tissue of HBV-HCC and HBV-control with no or mild fibrosis was evaluated. A total of 40 differentially expressed miRNAs were identified in HCC. Among ten highly altered miRNAs, six miRNAs were successfully validated in tissues, whereas only two miRNAs, miR-126 and miR-142-3p showed increased expression in plasma of HBV-HCC compared to HBV-non-HCC patients...
June 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26755878/hepatocellular-carcinoma-mouse-models-hepatitis-b-virus-associated-hepatocarcinogenesis-and-haploinsufficient-tumor-suppressor-genes
#20
REVIEW
Yuan-Chi Teng, Zhao-Qing Shen, Cheng-Heng Kao, Ting-Fen Tsai
The multifactorial and multistage pathogenesis of hepatocellular carcinoma (HCC) has fascinated a wide spectrum of scientists for decades. While a number of major risk factors have been identified, their mechanistic roles in hepatocarcinogenesis still need to be elucidated. Many tumor suppressor genes (TSGs) have been identified as being involved in HCC. These TSGs can be classified into two groups depending on the situation with respect to allelic mutation/loss in the tumors: the recessive TSGs with two required mutated alleles and the haploinsufficient TSGs with one required mutated allele...
January 7, 2016: World Journal of Gastroenterology: WJG
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