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https://www.readbyqxmd.com/read/28445292/prognostic-value-of-immunoscore-to-identify-mortality-outcomes-in-adults-with-hbv-related-primary-hepatocellular-carcinoma
#1
Qinwei Yao, Xuli Bao, Ran Xue, Hui Liu, Haixia Liu, Juan Li, Jinling Dong, Zhonghui Duan, Meixin Ren, Juan Zhao, Qi Song, Hongwei Yu, Yueke Zhu, Jun Lu, Qinghua Meng
This study aimed to determine if the immunoscore (IS) staging system would be a potential prognostic factor in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) in China.IS was performed in a consecutive cohort of HBV-HCC patients (n= 92). CD3+, CD8+, and CD45RO+ T cells were quantified by immunohistochemical analyses. The patients were stratified into 5 IS groups: I0, I1, I2, I3, I4 for every 2 cell phenotypes (IS1 (CD8/CD45RO, IS2 (CD3/CD8), and IS3 (CD3/CD45RO), respectively. ImagePro Plus software was used in the calculation of the paraffin-embedded tumor sections...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28413603/hepatitis-b-virus-promotes-cancer-cell-migration-by-downregulating-mir-340-5p-expression-to-induce-stat3-overexpression
#2
Qiushuang Xiong, Shaoshuai Wu, Jingwen Wang, Xianhuang Zeng, Jianwen Chen, Mingcong Wei, Haotong Guan, Chengpeng Fan, Lang Chen, Deyin Guo, Guihong Sun
BACKGROUND: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and infection with hepatitis B virus (HBV) is a leading cause of HCC. Previous studies have demonstrated that expression of the tumor inhibitor miR-340 is significantly downregulated in HCC tissues compared with normal liver tissues. However, the precise biological role of miR-340-5p in HBV-HCC and its molecular mechanism of action remain unknown. RESULTS: Expression of miR-340-5p was downregulated in HBV-associated HCC liver tissue and HBV-infected cells, facilitating migration of liver cancer cells...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28373975/increased-erp57-expression-in-hbv-related-hepatocellular-carcinoma-possible-correlation-and-prognosis
#3
Miao Liu, Lingyao Du, Zhiliang He, Libo Yan, Ying Shi, Jin Shang, Hong Tang
Aim. ERp57 is involved in virus induced endoplasmic reticulum stress (ERS) and plays an important role in tumorigenesis. This study aimed to find whether HBV infection altered ERp57 expression and whether ERp57 regulation was involved in hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) genesis. Materials and Methods. HBV-HCC tissues, chronic hepatitis B (CHB) liver tissues, and normal liver tissues were acquired. ERp57 expressions in these tissues were detected through immunohistochemistry (IHC)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28339081/hbx-represses-riz1-expression-by-dna-methyltransferase%C3%A2-1-involvement-in-decreased-mir-152-in-hepatocellular-carcinoma
#4
Zhujiang Zhao, Ying Hu, Xiaohui Shen, Yingbin Lao, Lihua Zhang, Xuemei Qiu, Jiaojiao Hu, Pihai Gong, He Cui, Sen Lu, Ying Zheng, Menghan Zhou, Hong Fan
Hepatitis B virus (HBV) is mainly suspected to promote hepatocellular carcinoma (HCC) development by epigenetic alteration. The HBV X protein (HBx) plays a key role in the molecular pathogenesis of HBV-related HCC. However, the mechanism of HBx-mediated hepatocarcinogenesis remains to be elucidated. RIZ1 gene, a candidate HCC suppressor gene, is frequently found to be hypermethylated and downregulated in HCC. In the present study, we show that the expression of RIZ1 was downregulated in 65% HCC tissues. Decreased expression of RIZ1 was restored by 5'-Aza in MHCC-97H HCC cell lines...
March 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28322348/several-micrornas-could-predict-survival-in-patients-with-hepatitis-b-related-liver-cancer
#5
Ye Zhen, Zhao Xinghui, Wu Chao, Zhao Yi, Chen Jinwen, Gao Ruifang, Zhang Chao, Zhao Min, Guo Chunlei, Fang Yan, Du Lingfang, Shen Long, Shen Wenzhi, Luo Xiaohe, Xiang Rong
MicroRNAs as biomarkers play an important role in the tumorigenesis process, including hepatocellular carcinomas (HCCs). In this paper, we used The Cancer Genome Atlas (TCGA) database to mine hepatitis B-related liver cancer microRNAs that could predict survival in patients with hepatitis B-related liver cancer. There were 93 cases of HBV-HCC and 49 cases of adjacent normal controls included in the study. Kaplan-Meier survival analysis of a liver cancer group versus a normal control group of differentially expressed genes identified eight genes with statistical significance...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286056/detection-of-hbv-dna-and-antigens-in-hbsag-positive-patients-with-primary-hepatocellular-carcinoma
#6
Sha Fu, Ning Li, Peng-Cheng Zhou, Yan Huang, Rong-Rong Zhou, Xue-Gong Fan
BACKGROUND: Hepatitis B virus (HBV) markers include HBV deoxyribonucleic acid (DNA) and HBV antigens. The former involves HBV covalently closed circular DNA (cccDNA) as well as total HBV DNA, whereas the latter involves HBsAg, HBcAg, and HBx. METHODS: Samples of tumor and adjacent non-tumor liver tissue were collected from 28 HBV-associated HCC patients. Intrahepatic total HBV DNA and cccDNA were measured using the real-time PCR Taqman assay. HBV antigens in hepatocytes were detected using immunohistochemical staining...
March 9, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/28271685/the-expression-of-b7-h3-in-circulating-cd4-cd25high-t-cells-circulating-cd14-monocytes-and-plasma-during-hepatitis-b-virus-infection-progression
#7
Jun-Chi Xu, Ming Li, Yuan Ma, Cui-Lin Shi, Xiao-Yan Zhu, Hua-Feng Song, Hui Chen, Chuan-Wu Zhu, Ping Xu
BACKGROUND: B7-H3 is frequently upregulated in response to autoantigens and pathogens during host T cell immune responses. However, the role of B7-H3 which express in CD14+ monocytes and CD4+CD25high T cells had not been investigated. METHODS: Cytometry and ELISA were used in this study. RESULTS: The study showed that B7-H3 expression in CD14+ monocytes, CD4+CD25high T cells, and plasma was significantly increased in AHB, CHB, HBV-LC, and HBV-HCC group...
March 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28079114/discovering-potential-serological-biomarker-for-chronic-hepatitis-b-virus-related-hepatocellular-carcinoma-in-chinese-population-by-mal-associated-serum-glycoproteomics-analysis
#8
Tianhua Liu, Denghe Liu, Riqiang Liu, Hucong Jiang, Guoquan Yan, Wei Li, Lu Sun, Shu Zhang, Yinkun Liu, Kun Guo
The accuracy of current biomarkers for the diagnosis of hepatocellular carcinoma (HCC), especially chronic Hepatitis B Virus (HBV)-related HCC, is limited. Recent progress in glycoproteomics has provided a novel platform for screening novel serological biomarkers of HCC. In this study, lectin affinity chromatography by Maackia amurensis lectin (MAL) and iTRAQ combined with mass spectrometric analysis were performed to enrich and identify the glycoprotein fractions in serum samples from HBV-related HCC patients and from healthy controls...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27977601/three-polymorphisms-of-tumor-necrosis-factor-alpha-and-hepatitis-b-virus-related-hepatocellular-carcinoma-a-meta-analysis
#9
Qi Xiao, BiQi Fu, Ping Chen, Zhong Zhong Liu, Wei Wang, QiFa Ye
BACKGROUND: To assess the association between tumor necrosis factor-alpha (TNF-α) G308A, G238A and C863T polymorphisms and hepatitis B virus related hepatocellular carcinoma (HBV-HCC) susceptibility. METHODS: We interrogated the databases of Pubmed, Sciencedirect and Viley online library up to March 8, 2016. Odds ratios (ORs) and corresponding 95% confidence intervals (95%CIs) were calculated in a fixed-effects model or a random-effects model when appropriate. RESULTS: In total, 12 case-control studies which containing 1580 HBV-HCC cases, 2033 HBV carrier controls, 395 HBV spontaneously recovered (SR) controls and 1116 healthy controls were included...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27925189/hbx-drives-alpha-fetoprotein-expression-to-promote-initiation-of-liver-cancer-stem-cells-through-activating-pi3k-akt-signal-pathway
#10
Mingyue Zhu, Wei Li, Yan Lu, Xu Dong, Bo Lin, Yi Chen, Xueer Zhang, Junli Guo, Mengsen Li
Hepatitis B virus (HBV)-X protein (HBx) plays critical role in inducing the malignant transformation of liver cells. Alpha fetoprotein (AFP) expression is closely related to hepatocarcinogenesis. We report that Oct4, Klf4, Sox2 and c-myc expression positively associated with AFP(+)/HBV(+) hepatocellular carcinoma(HCC) tissues, and the expression of the stemness markers CD44, CD133 and EpCAM was significantly higher in AFP(+)/HBV(+) HCC tissues compared to normal liver tissues or AFP (-)/HBV(-) HCC tissues. AFP expression turned on prior to expression of Oct4, Klf4, Sox2 and c-myc, and the stemness markers CD44, CD133 and EpCAM in the normal human liver L-02 cell line or CHL cell lines upon transfection with MCV-HBx vectors...
March 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27792999/genetic-variant-in-visfatin-gene-promoter-contributes-to-reduced-risk-of-hepatocellular-carcinoma-in-a-chinese-population
#11
Zhitong Wu, Yifan Sun, Yiyong Huang, Shengbo Zhu, Yi Feng, Huifen Ye, Chunming Liu, Shifu Tang
Knowledge on the role of gene variants in the visfatin promoter region in the hepatitis B virus (HBV)-related liver diseases is limited. In this study, we genotyped two potentially functional single nucleotide polymorphisms (SNPs) in the visfatin promoter region, -1535C>T (rs61330082) and -3187G>A (rs11977021), in 120 HBV-related chronic hepatitis B (CHB) patients, 140 HBV-related liver cirrhosis (HBV-LC) patients, 243 HBV-related hepatocellular carcinoma (HBV-HCC) patients, and 224 asymptomatic HBV carriers...
November 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27729742/increased-atg5-atg12-in-hepatitis-b-virus-associated-hepatocellular-carcinoma-and-their-role-in-apoptosis
#12
Areerat Kunanopparat, Ingorn Kimkong, Tanapat Palaga, Pisit Tangkijvanich, Boonchoo Sirichindakul, Nattiya Hirankarn
AIM: To investigate autophagy-related genes, particularly ATG12, in apoptosis and cell cycle in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) and non-HBV-HCC cell lines. METHODS: The expression of autophagy-related genes in HBV-associated hepatocellular carcinoma and non-HBV-HCC cell lines and human liver tissues was examined by quantitative real-time reverse transcriptase-polymerase chain reaction (qRT-PCR) and western blotting. The silencing of target genes was used to examine the function of various genes in apoptosis and cell cycle progression...
October 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27725462/recognition-of-infection-status-of-outpatient-treatment-and-treatment-history-before-carcinogenesis-in-patients-with-viral-hepatitis-associated-liver-cancer
#13
Michihiko Shibata, Sota Minami, Shinji Oe, Koichiro Miyagawa, Yuichi Honma, Ryo Onitsuka, Michio Senju, Masaaki Hiura, Riko Harada, Shintaro Abe, Akinari Tabaru, Masaru Harada
We conducted a survey on the recognition of infection, status of outpatient treatment, and treatment history in hepatitis virus-associated hepatocellular carcinoma patients admitted to our department between 2005 and 2014. We compared these parameters in 75 patients with primary hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) and 307 patients with hepatitis C virus-associated hepatocellular carcinoma (HCV-HCC). Based on the presence or absence of outpatient treatment in medical institutions at the time of HCC diagnosis, the patients were divided into an outpatient treatment-free group or an outpatient treated group...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27708241/hepatitis-b-virus-x-induces-inflammation-and-cancer-in-mice-liver-through-dysregulation-of-cytoskeletal-remodeling-and-lipid-metabolism
#14
Zhongwei Xu, Linghui Zhai, Tailong Yi, Huiying Gao, Fengxu Fan, Yanchang Li, Youliang Wang, Ning Li, Xiaohua Xing, Na Su, Feilin Wu, Lei Chang, Xiuli Chen, Erhei Dai, Chao Zhao, Xiao Yang, Chunping Cui, Ping Xu
Hepatitis B virus X protein (HBx) participates in the occurrence and development processes of hepatocellular carcinoma (HCC) as a multifunctional regulation factor. However, the underlying molecular mechanism remains obscure. Here, we describe the use of p21HBx/+ mouse and SILAM (Stable Isotope Labeling in Mammals) strategy to define the pathological mechanisms for the occurrence and development of HBx induced liver cancer. We systematically compared a series of proteome samples from regular mice, 12- and 24-month old p21HBx/+ mice representing the inflammation and HCC stages of liver disease respectively and their nontransgenic wild-type (WT) littermates...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27662665/metavir-and-fib-4-scores-are-associated-with-patient-prognosis-after-curative-hepatectomy-in-hepatitis-b-virus-related-hepatocellular-carcinoma-a-retrospective-cohort-study-at-two-centers-in-china
#15
Rui Liao, Yi-Peng Fu, Ting Wang, Zhi-Gang Deng, De-Wei Li, Jia Fan, Jian Zhou, Gen-Sheng Feng, Shuang-Jian Qiu, Cheng-You Du
Although Metavir and Fibrosis-4 (FIB-4) scores are typically used to assess the severity of liver fibrosis, the relationship between these scores and patient outcome in hepatocellular carcinoma (HCC) is unclear. The aim of this study was to evaluate the prognostic value of the severity of hepatic fibrosis in HBV-related HCC patients after curative resection. We examined the prognostic roles of the Metavir and preoperative FIB-4 scores in 432 HBV-HCC patients who underwent curative resection at two different medical centers located in western (Chongqing) and eastern (Shanghai) China...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27547000/prediction-and-prophylaxis-of-hepatocellular-carcinoma-occurrence-and-postoperative-recurrence-in-chronic-hepatitis-b-virus-infected-subjects
#16
EDITORIAL
Yan Du, Xue Han, Yi-Bo Ding, Jian-Hua Yin, Guang-Wen Cao
Hepatocellular carcinoma (HCC) is one of the most common and highly fatal malignancies worldwide. Chronic infection with hepatitis B virus (HBV) is a major cause of HCC. High HBV replication rate and related non-resolving inflammation are the major risk factors of HCC occurrence and postoperative recurrence. Early prophylactic options are effective in reducing HCC occurrence and improving survival. Therefore, it is important to identify HBV-infected patients who are at a higher risk of developing HCC and HBV-HCC patients who are more likely to relapse after surgery, thus providing them with more precise prophylactic strategies...
August 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27537392/impact-of-non-neoplastic-vs-intratumoural-hepatitis-b-viral-dna-and-replication-on-hepatocellular-carcinoma-recurrence
#17
Qin Wang, Luan Lin, Seungyeul Yoo, Wenhui Wang, Sima Blank, M Isabel Fiel, Hena Kadri, Wei Luan, Leslie Warren, Jun Zhu, Spiros P Hiotis
BACKGROUND: This study aims to determine the impact of intracellular hepatitis B virus (HBV) DNA, covalently closed circular DNA (cccDNA) and viral replicative activity in both tumour and non-neoplastic liver on prognosis and to determine the relationship of viral replicative activity and Ishak fibrosis in predicting outcome following resection. METHODS: A total of 99 prospectively enrolled patients treated with primary liver resection for HBV-HCC are included. Intracellular HBV DNA and cccDNA were quantitated by real-time PCR...
September 27, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27495026/hbv-is-a-risk-factor-for-poor-patient-prognosis-after-curative-resection-of-hepatocellular-carcinoma-a-retrospective-case-control-study
#18
COMPARATIVE STUDY
Zhonghu Li, Xin Zhao, Peng Jiang, Senlin Xiao, Guo Wu, Kai Chen, Xi Zhang, Hui Liu, Xiuguo Han, Shuguang Wang, Xiaowu Li
Controversy exists regarding pathological factors affecting the prognosis of hepatocellular carcinoma (HCC) patients with hepatitis B virus (HBV-HCC). Their postoperative clinical behaviors and the exact HBV Deoxyribonucleic Acid (DNA) thresholds that distinguish good and poor prognoses are unknown. This study aimed to compare clinicopathological, pre- and postoperative clinical factors and overall and recurrence-free survival (RFS) between HBV-HCC patients and nonhepatitis B and nonhepatitis C HCC (NBC-HCC) patients to determine the optimal prognostic HBV DNA threshold...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27402267/tagln2-a-novel-regulator-involved-in-hepatitis-b-virus-transcription-and-replication
#19
Youjia Yu, Zhiliang He, Yong Cao, Hong Tang, Feijun Huang
Hepatitis B virus (HBV) infection is one of the major health problems in the world. Transgelin-2 (TAGLN2) expression has been revealed to be significantly altered in previous studies concerning HBV-host interaction. The present study investigated TAGLN2 expression patterns in HBV related hepatocellular carcinoma (HCC) tissues and its role in HBV transcription and replication. We collected 59 HBV related HCC tissue samples, their adjacent non-tumoral tissues and 16 normal livers to make the tissue microarray...
September 2, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27248055/comparison-of-genome-scale-dna-methylation-profiles-in-hepatocellular-carcinoma-by-viral-status
#20
Min-Ae Song, Sandi A Kwee, Maarit Tiirikainen, Brenda Y Hernandez, Gordon Okimoto, Naoky C Tsai, Linda L Wong, Herbert Yu
Hepatocellular carcinoma (HCC) incidence has steadily increased in the US over the past 30 years. Our understanding of epigenetic regulation in HCC is still limited, especially the impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on aberrant DNA methylation. We performed genome-wide DNA methylation profiling in 33 fresh frozen tumor samples, including 10 HBV-HCC, 13 HCV-HCC, and 10 non-infected (NIV-HCC) using the Illumina HumanMethylation450 BeadChip. Gene expression profiling was also performed using the Illumina whole-genome DASL HT Assay...
June 2, 2016: Epigenetics: Official Journal of the DNA Methylation Society
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