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Ying Hu, Xin Zhou, Hyeseung Jung, Sang-Jip Nam, Myung Hwa Kim, Juyoung Yoon
Because of the current shortage of first-generation phosgene sensors, increased attention has been given to the development of fluorescent and colorimetric based methods for detecting this toxic substance. In an effort focusing on this issue, we designed the new, second-generation phosgene chemosensor 1, and demonstrated that it undergoes a ring-opening reaction with phosgene in association with color and fluorescent changes with a detection limit of 3.2 ppb. Notably, in comparison with the first-generation sensor RB-OPD, 1 not only undergoes a much faster response towards phosgene with an overall response time within 2 min, but it also generates no by-products during the sensing process...
February 7, 2018: Analytical Chemistry
Myoung-Uoon Jang, Hye-Jeong Kang, Chang-Ku Jeong, Yewon Kang, Ji-Eun Park, Tae-Jip Kim
Cyclomaltodextrinases (CDases) belong to Glycoside Hydrolases (GH) family 13, which show versatile hydrolyzing and/or transglycosylation activity against cyclodextrin (CD), starch, and pullulan. Especially, some CDases have been reported to hydrolyze acarbose, a potent α-glucosidase inhibitor, and transfer the resulting acarviosine-glucose to various acceptors. In this study, a novel CDase (LPCD) gene was cloned from Lactobacillus plantarum WCFS1, which encodes 574 amino acids (64.6 kDa) and shares less than 44% of identities with the known CDase-family enzymes...
February 2018: Journal of Microbiology / the Microbiological Society of Korea
Philipp Damm, Jip Zonneveld, Sophie Brackertz, Florian Streitparth, Tobias Winkler
BACKGROUND: Total hip arthroplasty (THA) is in most cases improving patients´ life quality immediately after surgery. However, a closer look at these patients, especially with modern gait analysis methods, reveals also negative consequences due to the surgical approach related injury to the pelvic muscles. We hypothesized that this damage will have a negative impact on hip joint contact forces during activities of daily living (ADL). METHODS: 10 patients undergoing THA received an instrumented hip joint implant enabling real time in vivo measurements of hip joint loads using a direct lateral approach...
2018: PloS One
L-T Dinis, S Bernardo, A Luzio, G Pinto, M Meijón, M Pintó-Marijuan, A Cotado, C Correia, J Moutinho-Pereira
The foliar exogenous application of kaolin, a radiation-reflecting inert mineral, has proven to be an effective short-term climate change mitigation strategy for Mediterranean vineyards. In this work, we address the hypothesis that kaolin could improve both the hormonal dynamics and physiological responses of grapevines growing in Douro Region, northern Portugal. For this purpose, the leaf water potential, gas exchange and chlorophyll a fluorescence parameters were monitored, as well as the abscisic acid (ABA) and indole-3-acetic acid (IAA) quantification and immunolocalization were assessed...
November 23, 2017: Journal of Plant Physiology
Jaewoo Yoon, Min Kyoung Choi, Sang-Jip Nam
A Gram-stain-negative, strictly aerobic, yellow-colored, rod-shaped, chemoheterotrophic bacterium, designated SNA426T, was isolated from marine soil in the Republic of Korea. Preliminary analysis based on the 16S rRNA gene sequence revealed that the novel marine isolate was affiliated with the family Flavobacteriaceae of phylum Bacteroidetes and that it shared the highest (96.2%) sequence similarity with Gillisia mitskevichiae KMM 6034T. The strain could be differentiated phenotypically from related members of the family Flavobacteriaceae...
November 29, 2017: Archives of Microbiology
William Froehlich, Jip L Tolenaar, Kevin M Harris, Craig Strauss, Thoralf M Sundt, Thomas T Tsai, Mark D Peterson, Arturo Evangelista, Daniel G Montgomery, Eva Kline-Rogers, Christoph A Nienaber, James B Froehlich, Eric M Isselbacher, Kim A Eagle, Santi Trimarchi
OBJECTIVES: To analyze factors associated with delays to surgical management of Type A acute aortic dissection patients enrolled in the International Registry of Acute Aortic Dissection. METHODS: We evaluated 1880 surgically-managed Type A acute aortic dissection patients enrolled between 1996 and 2012 with data for times of diagnosis and surgery, accounting for demographic, clinical and diagnostic variables associated with surgical delay. RESULTS: The majority of patients were transferred (75...
November 24, 2017: American Journal of Medicine
Michiel H D Schoenaker, Stefanie S Henriet, Jip Zonderland, Marcel van Deuren, Qiang Pan-Hammarström, Sandra J Posthumus-van Sluijs, Ingrid Pico-Knijnenburg, Corry M R Weemaes, Hanna IJspeert
Bloom's syndrome (BS) is an autosomal recessive disease, caused by mutations in the BLM gene. This gene codes for BLM protein, which is a helicase involved in DNA repair. DNA repair is especially important for the development and maturation of the T and B cells. Since BLM is involved in DNA repair, we aimed to study if BLM deficiency affects T and B cell development and especially somatic hypermutation (SHM) and class switch recombination (CSR) processes. Clinical data of six BS patients was collected, and immunoglobulin serum levels were measured at different time points...
January 2018: Journal of Clinical Immunology
Eveline J M Verstraaten, Fenna M M Beeren, Jip L C Janssen, Sophie Kemper, Adiatma Y M Siregar, Noor Tromp, Rob Baltussen
BACKGROUND: the costs of HIV/AIDS interventions in Indonesia are largely unknown. Knowing these costs is an important input for policy makers in the decision-making of setting priorities among HIV/AIDS interventions. The aim of this analysis is to determine the costs of four HIV/AIDS interventions in Bandung, Indonesia in 2015, to inform the local AIDS commission. METHODS: data on utilization and costs of the different interventions were collected in a sexual transmitted infections (STI)-clinic and the KPA, the local HIV/AIDS commission, for the period of January 2015-December 2015...
July 2017: Acta Medica Indonesiana
Liang Zhang, Tao Hu, Erick Amombo, Guangyang Wang, Yan Xie, Jinmin Fu
Tall fescue (Festuca arundinacea Schreb) is a typical cool-season grass that is widely used in turf and pasture. However, high temperature as an abiotic stress seriously affects its utilization. The objective of this study was to explore the effect of spermidine (Spd) on heat stress response of tall fescue. The samples were exposed to 22°C (normal condition) or 44°C (heat stress) for 4 h. The results showed that exogenous Spd partially improved the quality of tall fescue leaves under normal temperature conditions...
2017: Frontiers in Plant Science
Ji-Peng Yang, Jian-Kai Yang, Chen Li, Zhi-Qiang Cui, Hong-Jiang Liu, Xiao-Feng Sun, Shao-Mei Geng, Sheng-Kui Lu, Jian Song, Cheng-Yong Guo, Bao-Hua Jiao
ZMYND11 (zinc finger MYND-type containing 11) has been widely regarded to be involved in a variety of cancers as a potential suppressor. However, the biological role and mechanism of ZMYND11 in glioblastoma multiform (GBM) remain unknown. In this study, we found that ZMYND11 expression was remarkably decreased in GBM tissues from 20 cases and cell line (U87) compared to normal brain tissue from 10 cases (P < 0.001). Furthermore, we explored that ZMYND11 upregulation significantly suppressed U87 cells proliferation and invasion, induced cell cycle arrest and apoptosis in vitro...
October 21, 2017: Biochemical and Biophysical Research Communications
Ling Li, Seul-Ah Kim, Ji Eun Heo, Tae-Jip Kim, Jin-Ho Seo, Nam Soo Han
GDP-l-fucose is an l-fucose donor to synthesize fucosylated compounds such as human milk oligosaccharides or Lewis antigen. In this study, we used Lactococcus lactis subsp. cremoris NZ9000 to express 4 enzymes, ManB, ManC, Gmd, and WcaG and produced GDP-l-fucose by using one-pot synthesis method with mannose-6-phosphate as substrate and the enzymes as biocatalyst. For preparation of enzyme mixture, 4 genes (manB, manC, gmd, and wcaG) cloned from Escherichia coli were transformed into L. lactis strains using pNZ8008 and the recombinant cell lysates were obtained after cultivation...
October 16, 2017: Journal of Biotechnology
Jae-Young Han, Hae In Jeong, Cheol-Woo Park, Jisoo Yoon, Jaeyoung Ko, Sang-Jip Nam, Byung-Kwan Lim
Coxsackievirus Type B3 (CVB3) is an enterovirus that belongs to the Picornaviridae and causes of various diseases such as myocarditis and hand-foot-mouth diseases. But effective antiviral drug was still not developed. In this study, we looking for potential inhibitors of CVB3 replication by examining survival of CVB3-infected HeLa cells. We detected an antiviral effect of cholic acid and identified it as a candidate inhibitor of CVB3 replication. Cholic acid circulates in the liver and intestines, and it helps digestion and absorption of lipids in small intestine...
October 14, 2017: Journal of Microbiology and Biotechnology
Lynn Melone, Lesley Price, Jennie Wilson
AIM: The aim of this cross-sectional survey was to determine the views of infection prevention and control practitioners (IPCPs) on publishing research. METHODS: A convenience sample was obtained by approaching delegates at the 2015 Infection Prevention Society conference and data were captured via a hand-held electronic device. FINDINGS: Of the 79 respondents, most (83%) read the Journal of Infection Prevention (JIP) and found it useful for informing their practice (72%)...
November 2016: Journal of Infection Prevention
Jip S M Gommers, Milou Diederen, Chris Wilkinson, Deborah Turnbull, Ben W J Mol
Induction of labour is one of the most frequently applied obstetrical interventions globally. Many studies have compared the use of balloon catheters with pharmacological agents. Although the safety of the balloon catheter is often mentioned, little has been written about the total spectrum of maternal and fetal morbidity associated with induction of labour using a balloon catheter. We evaluated the safety of labour induction with a transcervical balloon catheter by conducting a literature review with pooled risk assessments of the maternal, fetal and neonatal morbidity...
November 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jip F Prince, Maurice A A J van den Bosch, J F W Nijsen, Maarten L J Smits, Andor F van den Hoven, Stavros Nikolakopoulos, Frank J Wessels, Rutger C G Bruijnen, Manon Braat, Bernard A Zonnenberg, Marnix Lam
Rationale: Radioembolization of liver malignancies with holmium-166 (166Ho) microspheres has been shown safe in a phase 1 dose-escalation study. The purpose of this study was to investigate the efficacy of 166Ho radioembolization. Methods: In this prospective single-arm study, 56 patients were enrolled, all with liver metastases refractory to systemic therapy and ineligible for surgical resection. Radioembolization was performed with a projected average absorbed dose of 60 Gy to the liver (equal to 3.8 GBq/kg liver tissue)...
September 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Ivo Sedláček, Roman Pantůček, Stanislava Králová, Ivana Mašlaňová, Pavla Holochová, Eva Staňková, Roman Sobotka, Miloš Barták, Hans-Jürgen Busse, Pavel Švec
A bacterial strain designated CCM 8645(T) was isolated from a soil sample collected nearby a mummified seal carcass in the northern part of James Ross Island, Antarctica. The cells were short rods, Gram-stain-negative, non-motile, catalase and oxidase positive, and produced a red-pink pigment on R2A agar. A polyphasic taxonomic approach based on 16S rRNA gene sequencing, extensive biotyping using conventional tests and commercial identification kits and chemotaxonomic analyses were applied to clarify its taxonomic position...
October 2017: International Journal of Systematic and Evolutionary Microbiology
Kristien M Jipping, Jan Binne Hulshoff, Evita A van Amerongen, Tim I Bright, David I Watson, John Th M Plukker
BACKGROUND AND OBJECTIVES: The impact of different neoadjuvant chemoradiotherapy (nCRT) schedules and pathologic complete response (pCR) on the distribution of recurrence is unclear in esophageal cancer (EC). We assessed the effect of pCR and nCRT schedule in EC. METHODS: Patients with T1N+/T2-4aN0-3/M0 EC treated in different centers, with either carboplatin/paclitaxel/41.4 Gy (CROSS: n = 134) or Cisplatin/5-fluorouracil/45-50.4 Gy (Cis/5FU: n = 88) followed by surgery were included...
August 29, 2017: Journal of Surgical Oncology
Chae-Yoon Yim, Tu Cam Le, Tae Gu Lee, Inho Yang, Hansol Choi, Jusung Lee, Kyung-Yun Kang, Jin Sil Lee, Kyung-Min Lim, Sung-Tae Yee, Heonjoong Kang, Sang-Jip Nam, William Fenical
Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A-C (1-3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety...
August 3, 2017: Marine Drugs
Ji Sun Hwang, Geum Jin Kim, Hyun Gyu Choi, Min Cheol Kim, Dongyup Hahn, Joo-Won Nam, Sang-Jip Nam, Hak Choel Kwon, Jungwook Chin, Sung Jin Cho, Hayoung Hwang, Hyukjae Choi
Angiogenesis is the process of new blood vessel formation. Excessive angiogenesis is a critical factor in the progression of cancer, macular degeneration, and other chronic inflammatory diseases. When investigating the effects of crude extracts of cultured marine microorganisms, an extract of the cultured Streptomyces sp. YP127 strain was found to inhibit human umbilical vein endothelial cell (HUVEC) tube formation. Bioassay-guided fractionation and spectroscopic data analyses led to the identification of napyradiomycin A1 (1) as an antiangiogenic component of the extract...
August 25, 2017: Journal of Natural Products
Anthony Digrado, Aurélie Bachy, Ahsan Mozaffar, Niels Schoon, Filippo Bussotti, Crist Amelynck, Anne-Catherine Dalcq, Marie-Laure Fauconnier, Marc Aubinet, Bernard Heinesch, Patrick du Jardin, Pierre Delaplace
Several experiments have highlighted the complexity of stress interactions involved in plant response. The impact in field conditions of combined environmental constraints on the mechanisms involved in plant photosynthetic response, however, remains understudied. In a long-term field study performed in a managed grassland, we investigated the photosynthetic apparatus response of the perennial ryegrass (Lolium perenne L.) to environmental constraints and its ability to recover and acclimatize. Frequent field measurements of chlorophyll a fluorescence (ChlF) were made in order to determine the photosynthetic performance response of a population of L...
June 8, 2017: Physiologia Plantarum
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