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https://www.readbyqxmd.com/read/28433723/elimination-of-the-cryptic-plasmid-in-leuconostoc-citreum-by-crispr-cas9-system
#1
Ye-Ji Jang, Seung-Oh Seo, Seul-Ah Kim, Ling Li, Tae-Jip Kim, Sun Chang Kim, Yong-Su Jin, Nam Soo Han
Leuconostoc spp. are important lactic acid bacteria for the fermentation of foods. In particular, L. citreum strains isolated from various foods have been used as host strains for genetic and metabolic engineering studies. In order to develop a food-grade genetic engineering system, L. citreum CB2567 was isolated from Kimchi. However, the isolated bacterium contained a cryptic plasmid which was difficult to eliminate. As the existence of the plasmid might hinder strain engineering, we eliminated the plasmid using an RNA-guided DNA endonuclease CRISPR/Cas9 system...
April 19, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28405638/a-two-photon-fluorescent-probe-for-specific-detection-of-hydrogen-sulfide-based-on-a-familiar-esipt-fluorophore-bearing-aie-characteristics
#2
Liyan Chen, Di Wu, Chang Su Lim, Dayoung Kim, Sang-Jip Nam, Woolin Lee, Gyungmi Kim, Hwan Myung Kim, Juyoung Yoon
Hydrogen sulfide (H2S) is a signaling gasotransmitter, which plays various roles in modulating the functions of different systems. In this study, a "turn-on" fluorescent probe for H2S was developed. The probe, whose design is based on a familiar excited state intramolecular proton transfer (ESIPT) fluorophore bearing aggregation-induced emission (AIE) characteristics, was found to exhibit an 80-fold fluorescence enhancement along with a large Stokes shift upon the addition of H2S. Furthermore, the probe was successfully utilized to detect H2S in HeLa cells with both one-photon and two-photon microscopy...
April 13, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28365471/biosynthetic-pathways-of-aminoglycosides-and-their-engineering
#3
REVIEW
Je Won Park, Yeon Hee Ban, Sang-Jip Nam, Sun-Shin Cha, Yeo Joon Yoon
Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics. As Nature's gift, some aminoglycosides possess natural defensive structural elements that can circumvent drug resistance mechanisms. Thus, a detailed understanding of aminoglycoside biosynthesis will enable us to apply Nature's biosynthetic strategy towards expanding structural diversity in order to produce novel and more robust aminoglycoside analogs...
March 30, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28282745/overuse-wrist-injuries-in-young-athletes-what-do-sports-physicians-consider-important-signals-and-functional-limitations
#4
Laura S Kox, P Paul F M Kuijer, Jip Opperman, Gino M M J Kerkhoffs, Mario Maas, Monique H W Frings-Dresen
This study's objective was to collect items from experienced sports physicians, relating to the presence and severity of overuse wrist injuries in young athletes, for developing a measurement instrument for signals of overuse wrist injury. Seven Dutch elite sports physicians involved in guidance and treatment of young athletes in wrist-loading sports (gymnastics, tennis, judo, field hockey, volleyball and rowing) participated in a focus group. They discussed signals and limitations related to overuse wrist injuries in young athletes...
February 21, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28120195/heterologous-expression-and-enzymatic-characterization-of-%C3%AE-glutamyltranspeptidase-from-bacillus-amyloliquefaciens
#5
COMPARATIVE STUDY
Jung-Min Lee, Jaejung Lee, Gyeong-Hwa Nam, Byung-Sam Son, Myoung-Uoon Jang, So-Won Lee, Byung-Serk Hurh, Tae-Jip Kim
γ-Glutamyltranspeptidase (GGT) catalyzes the cleavage of γ-glutamyl compounds and the transfer of γ-glutamyl moiety to water or to amino acid/peptide acceptors. GGT can be utilized for the generation of γ-glutamyl peptides or glutamic acid, which are used as food taste enhancers. In the present study, Bacillus amyloliquefaciens SMB469 with high GGT activity was isolated from Doenjang, a traditional fermented soy food of Korea. The gene encoding GGT from B. amyloliquefaciens SMB469 (BaGGT469) was cloned from the isolate, and heterologously expressed in E...
February 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28099100/lung-shunting-an-indicator-of-survival-but-not-necessarily-a-tool-for-selecting-patients-for-radioembolization
#6
Maarten L J Smits, Remco Bastiaannet, Jip F Prince, Hugo W A M de Jong, Maurice A A J van den Bosch, Marnix G E H Lam
No abstract text is available yet for this article.
February 2017: Radiology
https://www.readbyqxmd.com/read/28095865/engineered-biosynthesis-of-milbemycins-in-the-avermectin-high-producing-strain-streptomyces-avermitilis
#7
Myoun-Su Kim, Wan-Je Cho, Myoung Chong Song, Seong-Whan Park, Kaeun Kim, Eunji Kim, Naryeong Lee, Sang-Jip Nam, Ki-Hoon Oh, Yeo Joon Yoon
BACKGROUND: Milbemycins, produced from Streptomyces hygroscopicus subsp. aureolacrimosus and Streptomyces bingchenggensis, are 16-membered macrolides that share structural similarity with avermectin produced from Streptomyces avermitilis. Milbemycins possess strong acaricidal, insecticidal, and anthelmintic activities but low toxicity. Due to the high commercial value of the milbemycins and increasing resistance to the avermectins and their derivatives, it is imperative to develop an efficient combinatorial biosynthesis system exploiting an overproduction host strain to produce the milbemycins and novel analogs in large quantities...
January 17, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28088020/sulphur-alters-chromium-vi-toxicity-in-solanum-melongena-seedlings-role-of-sulphur-assimilation-and-sulphur-containing-antioxidants
#8
Madhulika Singh, Bishwajit Kumar Kushwaha, Samiksha Singh, Vipin Kumar, Vijay Pratap Singh, Sheo Mohan Prasad
The present study investigates modulation in hexavalent chromium [Cr(VI) 25 μM] toxicity by sulphur (S; 0.5, 1.0 and 1.5 mM S as low (LS), medium (MS) and high sulphur (HS), respectively) in Solanum melongena (eggplant) seedlings. Biomass accumulation (fresh and dry weights), photosynthetic pigments, photosynthetic oxygen evolution and S content were declined by Cr(VI) toxicity. Furthermore, fluorescence characteristics (JIP-test) were also affected by Cr(VI), but Cr(VI) toxicity on photosystem II photochemistry was ameliorated by HS treatment via reducing damaging effect on PS II reaction centre and its reduction side...
December 27, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28068665/potent-inhibition-of-monoamine-oxidase-b-by-a-piloquinone-from-a-marine-derived-streptomyces-sp-cnq-027
#9
Hyun Woo Lee, Hansol Choi, Sang-Jip Nam, William Fenical, Hoon Kim
Two piloquinone derivatives isolated from Streptomyces sp. CNQ-027 were tested for the inhibitory activities of two isoforms of monoamine oxidase (MAO), which catalyzes monoamine neurotransmitters. The piloquinone 4,7-dihydroxy-3-methyl-2-(4-methyl-1-oxopentyl)-6H-dibenzo[b,d]pyran-6-one (1) was found to be a highly potent inhibitor of human MAO-B, with an IC₅₀ value of 1.21 µM; in addition, it was found to be highly effective against MAO-A, with an IC₅₀ value of 6.47 µM. Compound 1 was selective, but not extremely so, for MAO-B compared to MAO-A, with a selectivity index value of 5...
January 9, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28061401/the-effect-of-weight-bearing-asymmetry-on-dynamic-postural-stability-in-people-with-chronic-stroke
#10
Digna de Kam, Jip F Kamphuis, Vivian Weerdesteyn, Alexander C H Geurts
After stroke, weight-bearing asymmetry (WBA) towards the non-paretic side is associated with postural instability. It remains unknown whether WBA is a cause or consequence of postural instability, as both phenomena depend on stroke severity. We investigated the effect of WBA on the ability to recover from balance perturbations in people with stroke. Fourteen people in the chronic phase of stroke underwent multidirectional translational perturbations at three levels of initial WBA (0, 10 and 20% of body weight unloading of the paretic leg)...
December 21, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28043797/cadiolides-j-m-antibacterial-polyphenyl-butenolides-from-the-korean-tunicate-pseudodistoma-antinboja
#11
Weihong Wang, Hiyoung Kim, Rahul S Patil, Awadut G Giri, Dong Hwan Won, Dongyup Hahn, Youjung Sung, Jusung Lee, Hyukjae Choi, Sang-Jip Nam, Heonjoong Kang
Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J-M, 1, 3-5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid...
December 7, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27959364/an-efficient-two-photon-fluorescent-probe-for-human-nad-p-h-quinone-oxidoreductase-hnqo1-detection-and-imaging-in-tumor-cells
#12
Nahyun Kwon, Myoung Ki Cho, Sang Jun Park, Dayoung Kim, Sang-Jip Nam, Lei Cui, Hwan Myung Kim, Juyoung Yoon
A new quinone propionic acid locked TP fluorophore which can be used for human NAD(P)H:quinone oxidoreductase (hNQO1) detection was developed. The probe, TPQ, which displays high selectivity and anti-interference ability, was successfully applied to endogenous hNQO1 imaging and for the identification of different cancer cells.
January 3, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27891137/a-user-s-view-of-the-parameters-derived-from-the-induction-curves-of-maximal-chlorophyll-a-fluorescence-perspectives-for-analyzing-stress
#13
Julie Ripoll, Nadia Bertin, Luc P R Bidel, Laurent Urban
Analysis of the fast kinetics of the induction curve of maximal fluorescence represents a relatively recent development for chlorophyll a fluorescence measurements. The parameters of the so-called JIP-test are exploited by an increasingly large community of users to assess plant stress and its consequences. We provide here evidence that these parameters are capable to distinguish between stresses of different natures or intensities, and between stressed plants of different genetic background or at different developmental stages at the time of stress...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27843571/cachexia-in-cancer-what-is-in-the-definition
#14
Greetje Vanhoutte, Mick van de Wiel, Kristin Wouters, Michaël Sels, Linda Bartolomeeussen, Sven De Keersmaecker, Caroline Verschueren, Veronique De Vroey, Annemieke De Wilde, Elke Smits, Kin Jip Cheung, Liesbeth De Clerck, Petra Aerts, Didier Baert, Caroline Vandoninck, Sofie Kindt, Sofie Schelfhaut, Marc Vankerkhoven, Annelies Troch, Lore Ceulemans, Hanne Vandenbergh, Sven Leys, Tim Rondou, Elke Dewitte, Kristel Maes, Patrick Pauwels, Benedicte De Winter, Luc Van Gaal, Dirk Ysebaert, Marc Peeters
OBJECTIVE: This study aimed to provide evidence-based results on differences in overall survival (OS) rate to guide the diagnosis of cancer cachexia. DESIGN: Data collection and clinical assessment was performed every 3 months (5 visits): baseline data, muscle strength, nutritional and psychosocial status. 2 definitions on cachexia using different diagnostic criteria were applied for the same patient population. Fearon et al's definition is based on weight loss, body mass index (BMI) and sarcopenia...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27809460/effects-of-dietary-onion-allium-cepa-extract-supplementation-on-performance-apparent-total-tract-retention-of-nutrients-blood-profile-and-meat-quality-of-broiler-chicks
#15
Siska Aditya, Musabbir Ahammed, Seong Hun Jang, Sang Jip Ohh
OBJECTIVE: This study was conducted to investigate the effect of dietary onion (Allium cepa) extract (OE) supplementation on growth performance, apparent total tract retention (ATTR), blood profile, carcass characteristics and meat quality in broilers. METHODS: Four hundred male broiler chicks (Ross 308, 3-d old) were randomly allocated to four dietary treatments for 28 d feeding trial. Each treatment has five replications with 20 birds each. Four dietary treatments were designated according to the OE supplementation levels (0 as control, 5, 7...
February 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27793719/enabling-techniques-in-the-search-for-new-antibiotics-combinatorial-biosynthesis-of-sugar-containing-antibiotics
#16
REVIEW
Je Won Park, Sang-Jip Nam, Yeo Joon Yoon
Nature has a talent for inventing a vast number of natural products, including hybrids generated by blending different scaffolds, resulting in a myriad of bioactive chemical entities. Herein, we review the highlights and recent trends (2010 to 2016) in the combinatorial biosynthesis of sugar-containing antibiotics where nature's structural diversification capabilities are exploited to enable the creation of new anti-infective and anti-proliferative drugs. In this review, we describe the modern combinatorial biosynthetic approaches for polyketide synthase-derived complex and aromatic polyketides, non-ribosomal peptide synthetase-directed lipo-/glycopeptides, aminoglycosides, nucleoside antibiotics, and alkaloids, along with their therapeutic potential...
October 25, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27782851/surefire-infusion-system-versus-standard-microcatheter-use-during-holmium-166-radioembolization-study-protocol-for-a-randomized-controlled-trial
#17
Andor F van den Hoven, Jip F Prince, Rutger C G Bruijnen, Helena M Verkooijen, Gerard C Krijger, Marnix G E H Lam, Maurice A A J van den Bosch
BACKGROUND: An anti-reflux catheter (ARC) may increase the tumor absorbed dose during radioembolization (RE) by elimination of particle reflux and its effects on hemodynamics. Since the catheter is fixed in a centro-luminal position, it may also increase the predictive accuracy of a scout dose administration before treatment. The purpose of the SIM trial is to compare the effects of ARC use during RE with holmium-166 ((166)Ho) microspheres in patients with colorectal liver metastases (CRLM), with the use of a standard end-hole microcatheter...
October 25, 2016: Trials
https://www.readbyqxmd.com/read/27764179/exogenous-%C3%AE-aminobutyric-acid-improves-the-structure-and-function-of-photosystem-ii-in-muskmelon-seedlings-exposed-to-salinity-alkalinity-stress
#18
Lixia Xiang, Lipan Hu, Weinan Xu, Ai Zhen, Liang Zhang, Xiaohui Hu
Gamma-aminobutyric acid (GABA) is important in plant responses to environmental stresses. We wished to clarify the role of GABA in maintenance of photosynthesis in muskmelon seedlings (Cucumis melo L., cv. Yipintianxia) during saline-alkaline stress. To this end, we assessed the effect of GABA on the structure and function of the photosynthetic apparatus in muskmelon seedlings grown under saline-alkaline stress. These stresses in combination reduced net photosynthetic rate, gas-exchange, and inhibited photosystem II (PSII) electron transport as measured by the JIP-test...
2016: PloS One
https://www.readbyqxmd.com/read/27717580/transpedal-approach-for-iliac-artery-stenting-a-pilot-study
#19
Jips J Zachariah, Justin A Ratcliffe, Michael Ruisi, Joseph Puma, Olivier Bertrand, Tak Kwan
OBJECTIVE: To demonstrate the safety and feasibility of the transpedal approach as an alternate arterial access site for iliac artery intervention. BACKGROUND: The common femoral artery is the traditional access site for the endovascular treatment of iliac artery stenoses. However, this approach is associated with complication rates as high as 2%, including retroperitoneal bleeding which carries high patient morbidity and mortality. Furthermore, the standard femoral approach is associated with longer recovery times and longer time to ambulation which are important considerations especially when performing procedures in an ambulatory setting...
December 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/27704657/spontaneous-haemoperitoneum-in-pregnancy-and-endometriosis-a-case-series
#20
McI Lier, R F Malik, Jhtm van Waesberghe, J W Maas, D A van Rumpt-van de Geest, S F Coppus, J P Berger, B B van Rijn, P F Janssen, M A de Boer, Jip de Vries, F W Jansen, I A Brosens, C B Lambalk, V Mijatovic
OBJECTIVE: To report pregnancy outcomes of SHiP (spontaneous haemoperitoneum in pregnancy) and the association with endometriosis. DESIGN: Retrospective case note review. SETTING: Dutch referral hospitals for endometriosis. SAMPLE: Eleven women presenting with 15 events of SHiP. METHODS: In collaboration with the Dutch Working Group on Endometriosis, unpublished cases of SHiP that occurred in the Netherlands between 2010 and 2015 were retrieved...
January 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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