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Dayoung Kim, Eun Ju Lee, Jihye Lee, Alain S Leutou, Yern-Hyerk Shin, Bomi Choi, Ji Sun Hwang, Dongyup Hahn, Hyukjae Choi, Jungwook Chin, Sung Jin Cho, Yong Deog Hong, Jaeyoung Ko, Chi Nam Seong, Katherine N Maloney, Dong-Chan Oh, Inho Yang, Hayoung Hwang, Sang-Jip Nam
Antartin ( 1 ), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin ( 1 ) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase...
April 16, 2018: Marine Drugs
Lu Zhang, Xue Peng, Biyun Liu, Yi Zhang, Qiaohong Zhou, Zhenbin Wu
Excessive proliferation of filamentous green algae (FGA) has been considered an important factor resulting in the poor growth or even decline of submerged macrophytes. However, there is a lack of detailed information regarding the effect of decaying FGA on submerged macrophytes. This study aimed to investigate whether the decomposing liquid from Cladophora oligoclona negatively affects Hydrilla verticillata turion germination and seedling growth. The results showed that the highest concentrations of decomposing liquid treatments inhibited the turion germination rate, which was the lowest than other treatments, at only 84%...
March 30, 2018: Ecotoxicology and Environmental Safety
Todor K Krastev, Jip Beugels, Juliette Hommes, Andrzej Piatkowski, Irene Mathijssen, Rene van der Hulst
Importance: The use of autologous fat transfer (AFT) or lipofilling for correcting contour deformities is seen as one of the major breakthroughs in reconstructive plastic surgery. Its applications in facial reconstructive surgery have been of particular interest owing to the prospect of achieving autologous reconstruction by a minimally invasive approach. However, its unpredictability and variable degree of resorption have limited its utility and much skepticism still exists regarding its efficacy...
March 29, 2018: JAMA Facial Plastic Surgery
Malak Haidar, Zineb Rchiad, Hifzur Rahman Ansari, Fathia Ben-Rached, Shahin Tajeri, Perle Latre De Late, Gordon Langsley, Arnab Pain
Theileria annulata is an apicomplexan parasite that infects and transforms bovine macrophages that disseminate throughout the animal causing a leukaemia-like disease called tropical theileriosis. Using deep RNAseq of T. annulata-infected B cells and macrophages we identify a set of microRNAs induced by infection, whose expression diminishes upon loss of the hyper-disseminating phenotype of virulent transformed macrophages. We describe how infection-induced upregulation of miR-126-5p ablates JIP-2 expression to release cytosolic JNK to translocate to the nucleus and trans-activate AP-1-driven transcription of mmp9 to promote tumour dissemination...
March 23, 2018: PLoS Pathogens
Teruaki Nakatsuji, Tiffany H Chen, Anna M Butcher, Lynnie L Trzoss, Sang-Jip Nam, Karina T Shirakawa, Wei Zhou, Julia Oh, Michael Otto, William Fenical, Richard L Gallo
We report the discovery that strains of Staphylococcus epidermidis produce 6- N -hydroxyaminopurine (6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6-HAP selectively inhibited proliferation of tumor lines but did not inhibit primary keratinocytes. Resistance to 6-HAP was associated with the expression of mitochondrial amidoxime reducing components, enzymes that were not observed in cells sensitive to this compound. Intravenous injection of 6-HAP in mice suppressed the growth of B16F10 melanoma without evidence of systemic toxicity...
February 2018: Science Advances
Jun Li, Younghee Kwon, Kyung Soo Chung, Chang Su Lim, Dayoung Lee, Yongkang Yue, Jisoo Yoon, Gyoungmi Kim, Sang-Jip Nam, Youn Wook Chung, Hwan Myung Kim, Caixia Yin, Ji-Hwan Ryu, Juyoung Yoon
Rationale: Among the biothiols-related diseases, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection and can result in severe oxidative stress and damage to multiple organs. In this study, we aimed to develop a fluorescence chemosensor that can both detect GSH and further predict sepsis. Methods: In this study, two new naphthalene dialdehyde compounds containing different functional groups were synthesized, and the sensing abilities of these compounds towards biothiols and its applications for prediction of sepsis were investigated...
2018: Theranostics
Yi Yang, Woo Kyun Bae, Sang-Jip Nam, Min-Hye Jeong, Rui Zhou, So-Yeon Park, İsa Taş, Yun-Ho Hwang, Myong-Suk Park, Ik Joo Chung, Kyung Keun Kim, Jae-Seoun Hur, Hangun Kim
BACKGROUND: Endolichenic fungi are microbes that inhabit the thalli of lichens and produce various unique chemicals that can be used for pharmaceutical purposes. PURPOSE: This study screened a library of endolichenic fungal extracts to identify novel anticancer agents capable of suppressing the tumorigenicity of human cancer cells. METHODS: Active compounds were isolated from extracts of endolichenic fungi by column chromatography and reverse-phase HPLC...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Alain S Leutou, Inho Yang, Tu Cam Le, Dongyup Hahn, Kyung-Min Lim, Sang-Jip Nam, William Fenical
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
February 21, 2018: Journal of Antibiotics
Ying Hu, Xin Zhou, Hyeseung Jung, Sang-Jip Nam, Myung Hwa Kim, Juyoung Yoon
Because of the current shortage of first-generation phosgene sensors, increased attention has been given to the development of fluorescent and colorimetric based methods for detecting this toxic substance. In an effort focusing on this issue, we designed the new, second-generation phosgene chemosensor 1, and demonstrated that it undergoes a ring-opening reaction with phosgene in association with color and fluorescent changes with a detection limit of 3.2 ppb. Notably, in comparison with the first-generation sensor RB-OPD, 1 not only undergoes a much faster response towards phosgene with an overall response time within 2 min, but it also generates no by-products during the sensing process...
February 7, 2018: Analytical Chemistry
Myoung-Uoon Jang, Hye-Jeong Kang, Chang-Ku Jeong, Yewon Kang, Ji-Eun Park, Tae-Jip Kim
Cyclomaltodextrinases (CDases) belong to Glycoside Hydrolases (GH) family 13, which show versatile hydrolyzing and/or transglycosylation activity against cyclodextrin (CD), starch, and pullulan. Especially, some CDases have been reported to hydrolyze acarbose, a potent α-glucosidase inhibitor, and transfer the resulting acarviosine-glucose to various acceptors. In this study, a novel CDase (LPCD) gene was cloned from Lactobacillus plantarum WCFS1, which encodes 574 amino acids (64.6 kDa) and shares less than 44% of identities with the known CDase-family enzymes...
February 2018: Journal of Microbiology / the Microbiological Society of Korea
Philipp Damm, Jip Zonneveld, Sophie Brackertz, Florian Streitparth, Tobias Winkler
BACKGROUND: Total hip arthroplasty (THA) is in most cases improving patients´ life quality immediately after surgery. However, a closer look at these patients, especially with modern gait analysis methods, reveals also negative consequences due to the surgical approach related injury to the pelvic muscles. We hypothesized that this damage will have a negative impact on hip joint contact forces during activities of daily living (ADL). METHODS: 10 patients undergoing THA received an instrumented hip joint implant enabling real time in vivo measurements of hip joint loads using a direct lateral approach...
2018: PloS One
L-T Dinis, S Bernardo, A Luzio, G Pinto, M Meijón, M Pintó-Marijuan, A Cotado, C Correia, J Moutinho-Pereira
The foliar exogenous application of kaolin, a radiation-reflecting inert mineral, has proven to be an effective short-term climate change mitigation strategy for Mediterranean vineyards. In this work, we address the hypothesis that kaolin could improve both the hormonal dynamics and physiological responses of grapevines growing in Douro Region, northern Portugal. For this purpose, the leaf water potential, gas exchange and chlorophyll a fluorescence parameters were monitored, as well as the abscisic acid (ABA) and indole-3-acetic acid (IAA) quantification and immunolocalization were assessed...
January 2018: Journal of Plant Physiology
Jaewoo Yoon, Min Kyoung Choi, Sang-Jip Nam
A Gram-stain-negative, strictly aerobic, yellow-colored, rod-shaped, chemoheterotrophic bacterium, designated SNA426T , was isolated from marine soil in the Republic of Korea. Preliminary analysis based on the 16S rRNA gene sequence revealed that the novel marine isolate was affiliated with the family Flavobacteriaceae of phylum Bacteroidetes and that it shared the highest (96.2%) sequence similarity with Gillisia mitskevichiae KMM 6034T . The strain could be differentiated phenotypically from related members of the family Flavobacteriaceae...
November 29, 2017: Archives of Microbiology
William Froehlich, Jip L Tolenaar, Kevin M Harris, Craig Strauss, Thoralf M Sundt, Thomas T Tsai, Mark D Peterson, Arturo Evangelista, Daniel G Montgomery, Eva Kline-Rogers, Christoph A Nienaber, James B Froehlich, Eric M Isselbacher, Kim A Eagle, Santi Trimarchi
OBJECTIVES: The purpose of this research is to analyze factors associated with delays to surgical management of Type A acute aortic dissection patients. METHODS: Time from diagnosis to surgery and associated factors were evaluated in 1880 surgically managed Type A dissection patients enrolled in the International Registry of Acute Aortic Dissection. RESULTS: The majority of patients were transferred (75.7% vs 24.3%). Patients who were transferred had a median delay from diagnosis to surgery of 4...
March 2018: American Journal of Medicine
Michiel H D Schoenaker, Stefanie S Henriet, Jip Zonderland, Marcel van Deuren, Qiang Pan-Hammarström, Sandra J Posthumus-van Sluijs, Ingrid Pico-Knijnenburg, Corry M R Weemaes, Hanna IJspeert
Bloom's syndrome (BS) is an autosomal recessive disease, caused by mutations in the BLM gene. This gene codes for BLM protein, which is a helicase involved in DNA repair. DNA repair is especially important for the development and maturation of the T and B cells. Since BLM is involved in DNA repair, we aimed to study if BLM deficiency affects T and B cell development and especially somatic hypermutation (SHM) and class switch recombination (CSR) processes. Clinical data of six BS patients was collected, and immunoglobulin serum levels were measured at different time points...
January 2018: Journal of Clinical Immunology
Eveline J M Verstraaten, Fenna M M Beeren, Jip L C Janssen, Sophie Kemper, Adiatma Y M Siregar, Noor Tromp, Rob Baltussen
BACKGROUND: the costs of HIV/AIDS interventions in Indonesia are largely unknown. Knowing these costs is an important input for policy makers in the decision-making of setting priorities among HIV/AIDS interventions. The aim of this analysis is to determine the costs of four HIV/AIDS interventions in Bandung, Indonesia in 2015, to inform the local AIDS commission. METHODS: data on utilization and costs of the different interventions were collected in a sexual transmitted infections (STI)-clinic and the KPA, the local HIV/AIDS commission, for the period of January 2015-December 2015...
July 2017: Acta Medica Indonesiana
Liang Zhang, Tao Hu, Erick Amombo, Guangyang Wang, Yan Xie, Jinmin Fu
Tall fescue ( Festuca arundinacea Schreb) is a typical cool-season grass that is widely used in turf and pasture. However, high temperature as an abiotic stress seriously affects its utilization. The objective of this study was to explore the effect of spermidine (Spd) on heat stress response of tall fescue. The samples were exposed to 22°C (normal condition) or 44°C (heat stress) for 4 h. The results showed that exogenous Spd partially improved the quality of tall fescue leaves under normal temperature conditions...
2017: Frontiers in Plant Science
Ji-Peng Yang, Jian-Kai Yang, Chen Li, Zhi-Qiang Cui, Hong-Jiang Liu, Xiao-Feng Sun, Shao-Mei Geng, Sheng-Kui Lu, Jian Song, Cheng-Yong Guo, Bao-Hua Jiao
ZMYND11 (zinc finger MYND-type containing 11) has been widely regarded to be involved in a variety of cancers as a potential suppressor. However, the biological role and mechanism of ZMYND11 in glioblastoma multiform (GBM) remain unknown. In this study, we found that ZMYND11 expression was remarkably decreased in GBM tissues from 20 cases and cell line (U87) compared to normal brain tissue from 10 cases (P < 0.001). Furthermore, we explored that ZMYND11 upregulation significantly suppressed U87 cells proliferation and invasion, induced cell cycle arrest and apoptosis in vitro...
December 16, 2017: Biochemical and Biophysical Research Communications
Ling Li, Seul-Ah Kim, Ji Eun Heo, Tae-Jip Kim, Jin-Ho Seo, Nam Soo Han
GDP-l-fucose is an l-fucose donor to synthesize fucosylated compounds such as human milk oligosaccharides or Lewis antigen. In this study, we used Lactococcus lactis subsp. cremoris NZ9000 to express 4 enzymes, ManB, ManC, Gmd, and WcaG and produced GDP-l-fucose by using one-pot synthesis method with mannose-6-phosphate as substrate and the enzymes as biocatalyst. For preparation of enzyme mixture, 4 genes (manB, manC, gmd, and wcaG) cloned from Escherichia coli were transformed into L. lactis strains using pNZ8008 and the recombinant cell lysates were obtained after cultivation...
October 16, 2017: Journal of Biotechnology
Jae-Young Han, Hae In Jeong, Cheol-Woo Park, Jisoo Yoon, Jaeyoung Ko, Sang-Jip Nam, Byung-Kwan Lim
Coxsackievirus Type B3 (CVB3) is an enterovirus that belongs to the Picornaviridae and causes various diseases such as myocarditis and hand-foot-mouth disease. However, an effective antiviral drug is still not developed. In this study, we looked for potential inhibitors of CVB3 replication by examining the survival of CVB3-infected HeLa cells. We detected an antiviral effect by cholic acid and identified it as a candidate inhibitor of CVB3 replication. Cholic acid circulates in the liver and intestines, and it helps the digestion and absorption of lipids in the small intestine...
January 28, 2018: Journal of Microbiology and Biotechnology
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