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https://www.readbyqxmd.com/read/27193747/clinical-and-imaging-findings-in-an-infant-with-zika-embryopathy
#1
Marko Culjat, Stephen E Darling, Vivek R Nerurkar, Natascha Ching, Mukesh Kumar, Sarah K Min, Rupa Wong, Leon Grant, Marian E Melish
Recent Zika virus (ZIKV) outbreaks have been associated with an increased incidence of neonatal microcephaly. Subsequently, tropism for the brain was established in human fetal brain tissue. We present the first congenital ZIKV infection in the United States, confirmed by high ZIKV immunoglobulin M antibody titers in serum and cerebrospinal fluid. The phenotypic characteristics of the patient fall within fetal brain disruption sequence, suggesting impaired brain development in the second half of gestation. Brain imaging revealed an almost agyric brain with diffuse parenchymal calcifications, hydrocephalus ex vacuo, and cerebellar hypoplasia...
September 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/26679790/short-communication-experimental-toxocarosis-in-chinese-kun-ming-mice-dose-dependent-larval-distribution-and-modulation-of-immune-responses
#2
Guangxu Ma, Yancai Tan, Ling Hu, Yongfang Luo, Honghong Zhu, Rongqiong Zhou
Toxocarosis is an important parasitic zoonosis which is mainly caused by the infective larvae of Toxocara canis. To identify whether there are correlations among the infectious dose, the larval migrans and immune modulation in inbred Chinese Kun Ming (KM) mice, experimental infections were carried out with a range of dosages of 100, 500, 1000, 2000, and 3000 embryonated eggs (EE). Pathogenic reactions were observed in terms of physical and central nervous symptoms. Distributions of T. canis larvae in liver, lung, kidney, heart and brain organs were respectively detected by scanning tissue sections...
December 2015: Research in Veterinary Science
https://www.readbyqxmd.com/read/25816803/immunohistochemistry-and-molecular-epidemiology-of-avian-paramyxovirus-1-from-formalin-fixed-and-paraffin-embedded-sections-of-japanese-doves-columba-livia-affected-with-neurological-signs
#3
Kikuyasu Nakamura, Hideo Fujimori, Akiko Koyama, Trinh Quang Dai, Kunitoshi Imai, Mitsutaka Ikezawa, Yu Yamamoto
Four doves (Nos. 1-4 birds) affected with neurological signs (ataxia, circling and torticollis) were investigated pathologically and microbiologically. Viral isolation was tried from the tracheal and cloacal swabs of all 4 birds and from liver, spleen, kidney, heart, lung and brain of Nos. 1 and 2 birds. No viruses were isolated from 4 birds, but they had high serum antibody titers against avian paramyxovirus 1 (APMV-1). Histologically, they had the characteristic histological changes of pigeon APMV-1 infection; nonpurulent encephalitis and interstitial nephritis...
July 2015: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/25782571/histopathologic-lesions-in-conventional-pigs-experimentally-infected-with-haemophilus-parasuis-serovar%C3%A2-5
#4
A Palzer, R-L Austin-Busse, A Ladinig, G Balka, S Zoels, M Ritzmann
OBJECTIVE: In the present study various tissues of pigs were investigated for the presence of histopathologic lesions after an experimental infection with Haemophilus (H.) parasuis serovar 5. MATERIAL AND METHODS: Conventional pigs (n = 36) were divided into a control group B (n = 9) and a challenge group A (n = 27), which was infected intratracheally. Pigs that did not die prior to study termination were euthanized on day 14 post inoculation. Postmortem samples of the lung, heart, liver, kidney, spleen, left tarsal joint capsule and brain were collected...
2015: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/25489604/ruminal-acidosis-in-feedlot-from-aetiology-to-prevention
#5
REVIEW
Joaquín Hernández, José Luis Benedito, Angel Abuelo, Cristina Castillo
Acute ruminal acidosis is a metabolic status defined by decreased blood pH and bicarbonate, caused by overproduction of ruminal D-lactate. It will appear when animals ingest excessive amount of nonstructural carbohydrates with low neutral detergent fiber. Animals will show ruminal hypotony/atony with hydrorumen and a typical parakeratosis-rumenitis liver abscess complex, associated with a plethora of systemic manifestations such as diarrhea and dehydration, liver abscesses, infections of the lung, the heart, and/or the kidney, and laminitis, as well as neurologic symptoms due to both cerebrocortical necrosis and the direct effect of D-lactate on neurons...
2014: TheScientificWorldJournal
https://www.readbyqxmd.com/read/25014190/experimental-infection-of-mongolian-gerbils-with-baylisascaris-potosis
#6
T Tokiwa, K Taira, Y Une
The present study evaluated the pathogenicity of Baylisascaris potosis, a newly described ascarid nematode, in Mongolian gerbils. Gerbils were infected with varying doses of either B. potosis or Baylisascaris transfuga embryonated eggs (100, 1,000, and 4,000) for 30 days postinfection (pi). Baylisascaris potosis-infected gerbils showed no clinical signs of disease; however, gerbils exposed to 1,000 and 4,000 B. transfuga eggs showed severe neurologic signs at 22-29 days and 14-15 days pi, respectively. Histopathologic examination revealed larvae and lesions in the intestine, lung, liver, and muscles of B...
February 2015: Journal of Parasitology
https://www.readbyqxmd.com/read/23747106/humoral-immune-response-and-spreading-of-encephalitozoon-cuniculi-infection-in-experimentally-infected-ponies
#7
Pavla Wagnerová, Bohumil Sak, Dana Květoňová, Miroslav Maršálek, Iva Langrová, Martin Kváč
A total of 9 (8 stallions and 1 mare) 1 year old ponies were used for the experimental infection caused by Encephalitozoon cuniculi genotype II (10(7) spores per animal). Subsequently, individual horses were slaughtered 7, 14, 21, 28, 35, 42, 49, 56, and 63 days post infection. Immediately after slaughter, tissues samples of stomach, duodenum, jejunum, ileum, caecum, colon, spleen, liver, kidney, bladder, heart, lungs, and brain were sampled. In addition, urine, feces and blood specimens were collected. Enzyme-linked immunosorbent assay was used for determination of humoral immune response and nested PCR targeting 16S rDNA, whole ITS, and 5...
October 18, 2013: Veterinary Parasitology
https://www.readbyqxmd.com/read/23284845/enterovirus-71-induced-neurological-disorders-in-young-gerbils-meriones-unguiculatus-development-and-application-of-a-neurological-disease-model
#8
Ping-Ping Yao, Lei Qian, Yong Xia, Fang Xu, Zhang-Nv Yang, Rong-Hui Xie, Xiao Li, Wei-Feng Liang, Xiao-Xiao Huang, Zhi-Yong Zhu, Han-Ping Zhu
A reliable disease model mimicking Enterovirus 71 (EV71) infection in humans is essential for understanding pathogenesis and for developing a safe and effective vaccine. Commonly used rodent models including mouse or rat models are not suitable for vaccine evaluation because the rodents are resistant to EV71 infection after they reach the age of 6 days. In this study, 21-day-old gerbils inoculated intraperitoneally (IP) with a non mouse-adapted EV71 strain developed neurological lesion-related signs including hind limb paralysis, slowness, ataxia and lethargy similar to those of central nervous system (CNS) infection of EV71 in humans...
2012: PloS One
https://www.readbyqxmd.com/read/23270919/identification-and-molecular-characterization-of-a-novel-flavivirus-isolated-from-geese-in-china
#9
Xinmei Huang, Kaikai Han, Dongmin Zhao, Yuzhuo Liu, Jingfeng Zhang, Huimin Niu, Kangning Zhang, Jiangning Zhu, Dongming Wu, Lei Gao, Yin Li
Since April 2010, a novel contagious disease in ducks and geese, with egg drop, feed uptake decline and neurological signs, caused by a newly emerged virus has spread around Eastern China. Dissection conducted on the dead geese demonstrated hemorrhage in brain, lung, liver, heart, ovary, and enlarged and necrotic spleen. A new virus, named Goose/Jiangsu/804/2010 (JS804) virus, was isolated in Jiangsu area from geese. Then the virus was re-isolated from the affected geese and replicated well in duck embryo fibroblasts and Vero cells, causing the cytopathic effect...
June 2013: Research in Veterinary Science
https://www.readbyqxmd.com/read/23135030/combined-involvement-of-muscle-nerve-and-myoneural-junction-following-leptospira-infection
#10
Sunil Pradhan, Ruchika Tandon, Janak Kishore
Leptospirosis is a zoonosis prevalent worldwide and is endemic in many parts of India. In early leptospiremic as well as late immune phase of the disease kidney, liver, heart, and lungs are commonly involved. Neurological manifestations are rare but may occur during immune phase in the form of aseptic meningitis, meningoencephalitis, seizures, myelitis, polyradiculoneuritis, and myalgia. In this report, we describe a rare case of leptospirosis with combined involvement of nerve, muscle, and myoneural junction in generalized fashion along with pulmonary, renal, and hepatic dysfunction...
September 2012: Neurology India
https://www.readbyqxmd.com/read/22974597/-neurological-complications-in-patients-receiving-solid-organ-transplants
#11
J A Fernández-Ramos, E López-Laso, M D Ordóñez-Díaz, R Camino-León, I Ibarra-de la Rosa, M A Frías-Pérez, J J Gilbert-Pérez, J L Pérez-Navero
INTRODUCTION: Neurological complications (NC) are a significant cause of morbidity and mortality in paediatric patients receiving solid organ transplants. Our aim was to describe the experience of our hospital with NC in paediatric patients receiving heart, lung and liver transplants. PATIENTS AND METHODS: A retrospective study was conducted on 140 paediatric patients who received a solid organ transplant during the period 2000-2011. RESULTS: A total of 23 paediatric solid organ transplant recipients (16...
March 2013: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/22882294/congenital-cytomegalovirus-infection-patterns-of-fetal-brain-damage
#12
L Gabrielli, M P Bonasoni, D Santini, G Piccirilli, A Chiereghin, E Petrisli, R Dolcetti, B Guerra, M Piccioli, M Lanari, M P Landini, T Lazzarotto
Cytomegalovirus (CMV) is the most prevalent infectious agent causing neurological dysfunction in the developing brain. This study analysed the different patterns of tissue damage, particularly in the brain, of fetuses with documented CMV infection. We studied 45 fetuses at 20-21 weeks of gestation with congenital CMV infection documented by invasive positive prenatal diagnosis. At the time of amniocentesis, abnormal ultrasound findings had been recorded for 13 of the 45 fetuses (29%). Histological and immunohistochemical characterization was performed on the placenta, brain, heart, lung, liver, kidney, and pancreas...
October 2012: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/21741053/kinetics-and-pathogenicity-of-oral-infection-by-equine-herpesvirus-9-in-mice-and-suckling-hamsters
#13
E El-Nahass, N El-Habashi, A A Abdelaziz, M Nayel, S Kasem, H Fukushi, H Tuji, A Hirata, H Sakai, T Yanai
The pathogenesis and kinetics of oral infection by equine herpesvirus (EHV)-9 were studied in mice and hamsters. After oral inoculation of 10(5) plaque-forming units (PFU) of virus, 1-week-old suckling hamsters showed varying severity of neurological disease from 72 hours post inoculation (hpi) and all of these animals had died by 96 hpi. Four-week-old ICR mice inoculated orally with 4 × 10(4)PFU of virus showed no clinical signs, but they developed erosive and ulcerative gastritis from 36 hpi. Varying degrees of encephalitis were seen in infected mice and hamsters, and the hamsters also developed myelitis by 96 hpi...
February 2012: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/21500036/pathogenesis-of-highly-pathogenic-avian-influenza-a-virus-h7n1-infection-in-chickens-inoculated-with-three-different-doses
#14
Aida J Chaves, Nuria Busquets, Naiana Campos, Antonio Ramis, Roser Dolz, Raquel Rivas, Rosa Valle, F Xavier Abad, Ayub Darji, Natalia Majo
To study the pathogenesis of a H7N1 highly pathogenic avian influenza virus strain, specific pathogen free chickens were inoculated with decreasing concentrations of virus: 10(5.5) median embryo lethal dose (ELD(50)) (G1), 10(3.5) ELD(50) (G2) and 10(1.5) ELD(50) (G3). Disease progression was monitored over a period of 16 days and sequential necropsies and tissue samples were collected for histological and immunohistochemical examination. Viral RNA loads were also quantified in different tissues, blood, oropharyngeal swabs, and cloacal swabs using quantitative real-time reverse transcriptase-polymerase chain reaction (RT-qPCR)...
April 2011: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/21381344/-the-pattern-of-central-nervous-system-lesions-in-hiv-infected-patients-of-the-specialized-unit-in-infectious-disease-hospital
#15
A B Peregudova, V I Shakhgil'dian, O O Tsvetkova, T N Ermak, B M Gruzdev, M V Iuditskiĭ, O A Tishkevich, O Iu Shipulina, M V Al'vares Figeroa, A P Safonova, E A Dolgova, D B Goncharov
AIM: To define the incidence and features of brain lesion (BL) in HIV-infected inpatients. SUBJECTS AND METHODS: Four hundred and fifty-eight patients with Stage 4B HIV infection (AIDS) and central nervous system (CNS) lesion admitted to Infectious Diseases Hospital Two, Moscow, were followed up in 2003-2009. The authors used cerebrospinal fluid (CSF) microscopic and bacteriological assays for DNA of T. gondii, M. tuberculosis, herpes simplex virus (HSV) types 1 and 2, cytomegalovirus (CMV), HSV type 6, and varicella-zoster virus, Cr...
2010: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/21331944/unusual-and-severe-lesions-of-proventricular-dilatation-disease-in-cockatiels-nymphicus-hollandicus-acting-as-healthy-carriers-of-avian-bornavirus-abv-and-subsequently-infected-with-a-virulent-strain-of-abv
#16
S Payne, H L Shivaprasad, N Mirhosseini, P Gray, S Hoppes, H Weissenbock, I Tizard
A flock of 14 apparently healthy cockatiels, purchased from a single aviary, was tested for the presence of avian bornavirus (ABV). Twelve birds were found to be intermittently shedding ABV, predominantly genotype 4. Four of the cockatiels known to be shedding ABV4 were subsequently challenged with the tissue culture derived, virulent M24 strain of ABV4. The challenged birds remained in apparent good health until day 92 when one was found dead. The remaining three birds began to exhibit severe neurologic signs, ataxia and convulsions on day 110 and were euthanized...
February 2011: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/21234237/experimental-toxocara-cati-infection-in-gerbils-and-rats
#17
Mohammad Zibaei, Seyed Mahmoud Sadjjadi, Shoji Uga
Mongolian gerbils and Wistar rats were inoculated orally with 240 and 2,500 Toxocara cati embryonated eggs, respectively, to evaluate the larval recovery in different tissues and organs, such as the liver, lungs, heart, kidney, and skeletal muscles after 5, 30, 49, 70, and 92 days post-infection (PI). Larval recovery rates were 1.7-30.0% in Mongolian gerbils on days 5-92 PI and 0.2-3.8% in rats on the same days. These results indicate that Mongolian gerbils and Wistar rats are suitable experimental paratenic hosts for the study of neurological toxocariasis as well as visceral toxocariasis...
December 2010: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/20945785/unusual-biphasic-disease-in-domestic-pigeons-columba-livia-f-domestica-following-experimental-infection-with-sarcocystis-calchasi
#18
P Olias, A D Gruber, A O Heydorn, A Kohls, H M Hafez, M Lierz
A novel Sarcocystis species has recently been reported in the domestic pigeon (Columba livia f. domestica) as intermediate host, causing severe central nervous signs similar to Paramyxovirus-1 or Salmonella Typhimurium var. cop. infection. Transmission of the parasite via the northern goshawk (Accipiter gentilis) as definitive host has been established. Experimental infection of domestic pigeons with sporocysts excreted by experimentally infected northern goshawks reproduced the natural infection in the pigeon, proving the causative role of the parasite in the disease...
September 2010: Avian Diseases
https://www.readbyqxmd.com/read/20382820/variability-in-pathobiology-of-south-korean-h5n1-high-pathogenicity-avian-influenza-virus-infection-for-5-species-of-migratory-waterfowl
#19
Y K Kwon, C Thomas, D E Swayne
The pathobiology of H5N1 high-pathogenicity avian influenza (HPAI) virus infection in wild waterfowl is poorly understood. This study examined the pathobiology of A/chicken/Korea/IS/06 (H5N1) HPAI in 5 migratory waterfowl species--mute swans (Cygnus olor), greylag geese (Anser anser), ruddy shelducks (Tadorna ferruginea), mandarin ducks (Aix galericulata), and mallard ducks (Anas platyrhynchos)--following intranasal inoculation or contact exposure, from which all birds became infected. In mute swans, this virus had strong vascular endothelial cell tropism, producing acute severe disease and 100% mortality; the virus was detected in various parenchymal cells; and necrotic and inflammatory changes were noted in a range of organs, including pancreas, brain, spleen, heart, oral cavity, adrenal gland, lung, and liver...
May 2010: Veterinary Pathology
https://www.readbyqxmd.com/read/19573350/-pathology-of-enterovirus-71-infection-an-autopsy-study-of-5-cases
#20
Min Lu, Gang Meng, Yao-xin He, Jie Zheng, Song-lin Liao, Yan-feng Zhong, Xi-shun Zhao, Hong-quan Shao, Yu-ping Wang, Zhan-cheng Gao, Zi-fen Gao
OBJECTIVE: To study the clinicopathologic features of fatal enterovirus 71 (EV71) infection. METHODS: Autopsy was performed in 5 neonates died of EV71 infection. Tissue samples from major organs were collected, formalin-fixed and examined under light microscopy. Immunohistochemical study was carried out in selected examples. RESULTS: Four of the 5 cases showed predominant changes in central nervous system, with encephalitis and encephalomyelitis identified mainly in brainstem and upper cervical spinal cord...
February 2009: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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