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Rickettsias in childrens

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https://www.readbyqxmd.com/read/29776935/ocular-manifestations-of-rickettsia-in-children-common-but-frequently-overlooked
#1
Sara Homem de Melo Marques, Marta Gomes Guerra, Catarina Almeida, Miguel Ribeiro
We review two cases of ocular manifestations of Rickettsia conorii infection in children. A girl who presented unilateral visual loss with focal retinitis and macular oedema and a boy with unilateral central scotoma and bilateral anterior uveitis. Progressive functional and anatomic recovery was observed after oral antibiotics and steroids were initiated.
May 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29736763/serum-cytokine-responses-in-rickettsia-felis-infected-febrile-children-ghana
#2
Jessica Rauch, Peter Sothmann, Cassandra Aldrich, Ben Hogan, Ellis Owusu-Dabo, Jürgen May, Daniel Eibach, Dennis Tappe
The intracellular pathogen Rickettsia felis causes flea-borne spotted fever and is increasingly recognized as an emerging cause of febrile illness in Africa, where co-infection with Plasmodium falciparum is common. Rickettsiae invade endothelial cells. Little is known, however, about the early immune responses to infection. In this study, we characterize for the first time the cytokine profile in the acute phase of illness caused by R. felis infection, as well as in plasmodial co-infection, using serum from 23 febrile children < 15 years of age and 20 age-matched healthy controls from Ghana...
May 8, 2018: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/29685474/the-evaluation-and-management-of-rocky-mountain-spotted-fever-in-the-emergency-department-a-review-of-the-literature
#3
Michael Gottlieb, Brit Long, Alex Koyfman
BACKGROUND: Rocky Mountain spotted fever (RMSF) is potentially deadly and can present subtly with signs and symptoms overlapping with other clinical conditions. Delayed diagnosis can be fatal. OBJECTIVE: This review provides an evidence-based summary of the current data for the evaluation and management of RMSF in the emergency department. DISCUSSION: RMSF occurs through transmission of Rickettsia rickettsii by an infected tick. Exposure in the United States occurs most commonly from April to September, and high-risk locations include wooded, shrubby, or grassy areas...
April 20, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29617892/medical-knowledge-related-to-rocky-mountain-spotted-fever-in-sonora-mexico
#4
Gerardo Alvarez-Hernandez, Kacey Ernst, Natalia Haydee Acuña-Melendrez, Anabel Patricia Vargas-Ortega, Maria Del Carmen Candia-Plata
Background: Rocky Mountain spotted fever (RMSF) is a tick-borne disease with a high case-fatality rate unless diagnosed promptly and treated timely with doxycycline. Physician knowledge about presentation and treatment can improve outcomes of RMSF in endemic regions, such as Sonora in northern Mexico, where RMSF has caused 1348 non-fatal cases and 247 deaths from 2003 to 2016. Methods: A cross-sectional study was conducted with 343 physicians working in medical facilities in Sonora, Mexico...
March 29, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29465481/murine-typhus-in-south-texas-children-an-18-year-review
#5
Ashley Howard, Jaime Fergie
BACKGROUND: Murine typhus is a zoonotic infection caused by Rickettsia typhi that remains endemic in South Texas. In 2003, only 9 Texas counties reported murine typhus compared with 41 counties in 2013. METHODS: A retrospective study of children discharged with a confirmed diagnosis of murine typhus from Driscoll Children's Hospital between January 1998-September 2016. RESULTS: 213 children (113 female) 3 months through 19 years of age (mean, 11...
February 19, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29462726/clinically-diagnosed-mediterranean-spotted-fever-in-malta
#6
Paul Torpiano, David Pace
BACKGROUND: Mediterranean Spotted Fever (MSF) is a tick-borne zoonosis caused by Rickettsia conorii which is endemic in Malta, an island in the South Mediterranean that is a popular tourist destination. Diagnosis is frequently based on clinical manifestations as laboratory results are often limited to a retrospective diagnosis. We describe the clinical presentation, diagnosis and treatment of children <16 years who presented with MSF from 2011 to 2016. METHOD: The demographics, clinical findings, laboratory results, management and outcome of all children hospitalised with suspected MSF based on the presence of fever and an eschar, were retrieved from their case notes...
February 17, 2018: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29287070/a-diagnostic-and-epidemiologic-investigation-of-acute-febrile-illness-afi-in-kilombero-tanzania
#7
Christine Hercik, Leonard Cosmas, Ondari D Mogeni, Newton Wamola, Wanze Kohi, Victor Omballa, Melvin Ochieng, Shirley Lidechi, Juma Bonventure, Caroline Ochieng, Clayton Onyango, Barry S Fields, Sayoki Mfinanga, Joel M Montgomery
INTRODUCTION: In low-resource settings, empiric case management of febrile illness is routine as a result of limited access to laboratory diagnostics. The use of comprehensive fever syndromic surveillance, with enhanced clinical microbiology, advanced diagnostics and more robust epidemiologic investigation, could enable healthcare providers to offer a differential diagnosis of fever syndrome and more appropriate care and treatment. METHODS: We conducted a year-long exploratory study of fever syndrome among patients ≥ 1 year if age, presenting to clinical settings with an axillary temperature of ≥37...
2017: PloS One
https://www.readbyqxmd.com/read/29200167/a-severe-case-of-murine-typhus-presenting-with-anemia-and-severe-thrombocytopenia
#8
Jade Wulff, Judith Margolin, Nana E Coleman, Gail Demmler-Harrison, Fong Lam, Mona D Shah
We discuss a child with severe thrombocytopenia and mild anemia admitted to the Hematology service who quickly deteriorated to a life-threatening state. However, once rickettsial disease was considered in the differential diagnosis and empiric doxycycline begun, she quickly and fully recovered. A diagnostic panel, including Rickettsia typhi serology, confirmed the diagnosis of murine typhus but this occurred weeks after she had recovered. Given the potential severity of rickettsial diseases and the ease of modern travel across geographic borders, hematology-oncology providers everywhere must consider rickettsial diseases in their differential diagnosis of critically ill children and begin empiric therapy with doxycycline promptly...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28544092/fever-and-multiple-eschars-after-an-african-safari-report-of-three-cases
#9
Fátima Albízuri Prado, Alba Sánchez, Marta Feito, Ander Mayor, Ana Rodriguez, Raúl de Lucas
African tick-bite fever (ATBF), a tickborne disease endemic in rural areas of sub-Saharan Africa and the West Indies caused by Rickettsia africae, has been recognized as an emerging health problem in recent years. ATBF has been reported as the second most commonly documented etiology of fever, after malaria, in travelers who return ill from sub-Saharan Africa. Most cases reported in the literature occurred in middle-aged adults, so the incidence of ATBF in children is unclear. We report a cluster of three cases of ATBF that occurred in children ages 7 to 16 years after returning from a game-hunting safari in South Africa...
May 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28368858/epidemiological-evaluation-of-mediterranean-spotted-fever-in-children-of-the-karak-province-in-south-jordan
#10
Omar Nafi, Yasseen Tarawnah, Amjad Tarawnah
INTRODUCTION: The aim of this study was to describe the epidemiological patterns of Mediterranean spotted fever (MSF) as well as its treatment and outcomes in children in south Jordan. METHODOLOGY: A retrospective observational study was conducted from June 2013 to December 2015. Data regarding demographics, clinical presentation, laboratory findings, treatment, and outcomes were collected. RESULTS: In total, 35 male and 20 female patients (mean age: 6 years ± 3...
March 31, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28115672/-rickettsia-felis-infection-in-febrile-children-ghana
#11
Peter Sothmann, Christian Keller, Ralf Krumkamp, Benno Kreuels, Cassandra Aldrich, Nimako Sarpong, Stefanie Steierberg, Doris Winter, Kennedy Gyau Boahen, Ellis Owusu-Dabo, Jürgen May, Daniel Eibach
AbstractRickettsial infections are an underrecognized cause of febrile illness in sub-Saharan Africa. To evaluate the epidemiology and clinical features of rickettsial disease in pediatric patients in Ghana, we screened blood samples from febrile children aged less than 15 years presenting to an outpatient department in Ghana's Ashanti Region for the presence of rickettsial DNA. We detected Rickettsia felis in 7/470 (1.5%) blood samples, using two independent real-time polymerase chain reactions. No other Rickettsia species were found...
April 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27983969/clinical-and-laboratory-characteristics-epidemiology-and-outcomes-of-murine-typhus-a-systematic-review
#12
REVIEW
Constantinos Tsioutis, Maria Zafeiri, Asimakis Avramopoulos, Efthymia Prousali, Michael Miligkos, Spyridon A Karageorgos
Murine or endemic typhus, a febrile disease caused by Rickettsia typhi, is often misdiagnosed due to its non-specific presentation. We sought to evaluate all available evidence in the literature regarding the clinical and laboratory manifestations, epidemiological characteristics, and outcomes of murine typhus. Pubmed was searched for all articles providing available data. In an effort to incorporate contemporary data, only studies from 1980 were included. Thirty-three case series including 2074 patients were included in final analysis...
February 2017: Acta Tropica
https://www.readbyqxmd.com/read/27880753/notes-from-the-field-community-based-prevention-of-rocky-mountain-spotted-fever-sonora-mexico-2016
#13
Anne Straily, Naomi Drexler, Denica Cruz-Loustaunau, Christopher D Paddock, Gerardo Alvarez-Hernandez
Rocky Mountain spotted fever (RMSF), a life-threatening tickborne zoonosis caused by Rickettsia rickettsii, is a reemerging disease in Mexico (1,2). R. rickettsii is an intracellular bacterium that infects vascular endothelium and can cause multisystem organ failure and death in the absence of timely administration of a tetracycline-class antibiotic, typically doxycycline. Epidemic RMSF, as described in parts of Arizona and Mexico, is associated with massive local infestations of the brown dog tick (Rhiphicephalus sanguineus sensu lato) on domestic dogs and in peridomestic settings that result in high rates of human exposure; for example, during 2003-2012, in Arizona the incidence of RMSF in the three most highly affected communities was 150 times the U...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27861477/-complications-and-cause-of-death-in-mexican-children-with-rocky-mountain-spotted-fever
#14
Miguel Ángel Martínez-Medina, Adela Rascón-Alcantar
BACKGROUND: Rocky Mountain spotted fever is a life threatening disease caused by Rickettsia rickettsia, characterized by multisystem involvement. METHODS: We studied 19 dead children with Rocky Mountain spotted fever. All children who were suspected of having rickettsial infections were defined as having Rocky Mountain spotted fever by serology test and clinical features. Through the analysis of each case, we identified the clinical profile and complications associated to the death of a patient...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27737634/a-prospective-study-of-the-importance-of-enteric-fever-as-a-cause-of-non-malarial-febrile-illness-in-patients-admitted-to-chittagong-medical-college-hospital-bangladesh
#15
Rapeephan R Maude, Aniruddha Ghose, Rasheda Samad, Hanna K de Jong, Masako Fukushima, Lalith Wijedoru, Mahtab Uddin Hassan, Md Amir Hossain, Md Rezaul Karim, Abdullah Abu Sayeed, Stannie van den Ende, Sujat Pal, A S M Zahed, Wahid Rahman, Rifat Karnain, Rezina Islam, Dung Thi Ngoc Tran, Tuyen Thanh Ha, Anh Hong Pham, James I Campbell, H Rogier van Doorn, Richard J Maude, Tom van der Poll, W Joost Wiersinga, Nicholas P J Day, Stephen Baker, Arjen M Dondorp, Christopher M Parry, Md Abul Faiz
BACKGROUND: Fever is a common cause of hospital admission in Bangladesh but causative agents, other than malaria, are not routinely investigated. Enteric fever is thought to be common. METHODS: Adults and children admitted to Chittagong Medical College Hospital with a temperature of ≥38.0 °C were investigated using a blood smear for malaria, a blood culture, real-time PCR to detect Salmonella Typhi, S. Paratyphi A and other pathogens in blood and CSF and an NS1 antigen dengue ELISA...
October 13, 2016: BMC Infectious Diseases
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