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https://www.readbyqxmd.com/read/28411114/circulating-biologically-active-adrenomedullin-bio-adm-predicts-hemodynamic-support-requirement-and-mortality-during-sepsis
#1
Pietro Caironi, Roberto Latini, Joachim Struck, Oliver Hartmann, Andreas Bergmann, Giuseppe Maggio, Marco Cavana, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Serge Masson
BACKGROUND: The biological role of adrenomedullin, a hormone involved in hemodynamic homeostasis, is controversial in sepsis, since administration of either the peptide or an antibody against it may be beneficial. METHODS: Plasma bio-ADM was assessed on days 1, 2 and 7 after randomization of 956 patients with sepsis or septic shock to albumin or crystalloids for fluid resuscitation in the multicenter Albumin Italian Outcome Sepsis (ALBIOS) trial. We tested the association of bio-ADM and its time-dependent variation with fluid therapy, vasopressor administration, organ failures and mortality...
April 11, 2017: Chest
https://www.readbyqxmd.com/read/28331959/intensive-care-medicine-in-2050-ventilator-induced-lung-injury
#2
Luciano Gattinoni, Tommaso Tonetti, Michael Quintel
No abstract text is available yet for this article.
March 22, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28283699/opening-pressures-and-atelectrauma-in-acute-respiratory-distress-syndrome
#3
Massimo Cressoni, Davide Chiumello, Ilaria Algieri, Matteo Brioni, Chiara Chiurazzi, Andrea Colombo, Angelo Colombo, Francesco Crimella, Mariateresa Guanziroli, Ivan Tomic, Tommaso Tonetti, Giordano Luca Vergani, Eleonora Carlesso, Vladimir Gasparovic, Luciano Gattinoni
PURPOSE: Open lung strategy during ARDS aims to decrease the ventilator-induced lung injury by minimizing the atelectrauma and stress/strain maldistribution. We aim to assess how much of the lung is opened and kept open within the limits of mechanical ventilation considered safe (i.e., plateau pressure 30 cmH2O, PEEP 15 cmH2O). METHODS: Prospective study from two university hospitals. Thirty-three ARDS patients (5 mild, 10 moderate, 9 severe without extracorporeal support, ECMO, and 9 severe with it) underwent two low-dose end-expiratory CT scans at PEEP 5 and 15 cmH2O and four end-inspiratory CT scans (from 19 to 40 cmH2O)...
March 10, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28236256/evidence-or-belief-based-medicine-ten-doubts
#4
Luciano Gattinoni, John J Marini, Michael Quintel
No abstract text is available yet for this article.
February 24, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28212229/volutrauma-atelectrauma-and-mechanical-power
#5
Tommaso Tonetti, Massimo Cressoni, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Michael Quintel, Luciano Gattinoni
No abstract text is available yet for this article.
March 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28212205/spontaneous-breathing-during-extracorporeal-membrane-oxygenation-in-acute-respiratory-failure
#6
Stefania Crotti, Nicola Bottino, Giulia Maria Ruggeri, Elena Spinelli, Daniela Tubiolo, Alfredo Lissoni, Alessandro Protti, Luciano Gattinoni
BACKGROUND: We evaluate the clinical feasibility of spontaneous breathing on extracorporeal membrane oxygenation and the interactions between artificial and native lungs in patients bridged to lung transplant or with acute exacerbation of chronic obstructive pulmonary disease (COPD) or acute respiratory distress syndrome. METHODS: The clinical course of a total of 48 patients was analyzed. Twenty-three of 48 patients were enrolled in the prospective study (nine bridged to lung transplant, six COPD, and eight acute respiratory distress syndrome)...
April 2017: Anesthesiology
https://www.readbyqxmd.com/read/28074229/ventilation-induced-lung-injury-exists-in-spontaneously-breathing-patients-with-acute-respiratory-failure-we-are-not-sure
#7
EDITORIAL
Luciano Gattinoni
No abstract text is available yet for this article.
February 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/27898437/how-best-to-set-the-ventilator-on-extracorporeal-membrane-lung-oxygenation
#8
Luciano Gattinoni, Tommaso Tonetti, Michael Quintel
PURPOSE OF REVIEW: Extracorporeal respiratory support in patients with acute respiratory distress syndrome is applied either as rescue maneuver for life-threatening hypoxemia or as a tool to reduce the harm of mechanical ventilation. Depending on the blood and gas flow, extracorporeal support may completely substitute the natural lung as a gas exchanger (high-flow venovenous bypass) or reduce the need for mechanical ventilation, enabling the removal of a fraction of the metabolically produced CO2...
February 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27864924/pentraxin-3-in-patients-with-severe-sepsis-or-shock-the-albios-trial
#9
Pietro Caironi, Serge Masson, Tommaso Mauri, Barbara Bottazzi, Roberto Leone, Michela Magnoli, Simona Barlera, Filippo Mamprin, Andrea Fedele, Alberto Mantovani, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Roberto Latini
BACKGROUND: The long pentraxin PTX3 is a key component of the humoral arm of innate immunity related to sepsis severity and mortality. We evaluated the clinical and prognostic significance of circulating PTX3 in the largest cohort ever reported of patients with severe sepsis or septic shock. MATERIALS AND METHODS: Plasma PTX3 was measured on days 1, 2 and 7 after randomization of 958 patients to albumin or crystalloids for fluid resuscitation in the multicentre Albumin Italian Outcome Sepsis (ALBIOS) trial...
January 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27797616/fifty-years-of-research-in-ards-why-is-acute-respiratory-distress-syndrome-so-important-for-critical-care
#10
Luciano Gattinoni, Michael Quintel
No abstract text is available yet for this article.
November 1, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27757516/potentially-modifiable-factors-contributing-to-outcome-from-acute-respiratory-distress-syndrome-the-lung-safe-study
#11
John G Laffey, Giacomo Bellani, Tài Pham, Eddy Fan, Fabiana Madotto, Ednan K Bajwa, Laurent Brochard, Kevin Clarkson, Andres Esteban, Luciano Gattinoni, Frank van Haren, Leo M Heunks, Kiyoyasu Kurahashi, Jon Henrik Laake, Anders Larsson, Daniel F McAuley, Lia McNamee, Nicolas Nin, Haibo Qiu, Marco Ranieri, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
PURPOSE: To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality. METHODS: The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across five continents...
December 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27755036/in-reply
#12
Massimo Cressoni, Chiara Chiurazzi, Luciano Gattinoni
No abstract text is available yet for this article.
November 2016: Anesthesiology
https://www.readbyqxmd.com/read/27753501/noninvasive-ventilation-of-patients-with-acute-respiratory-distress-syndrome-insights-from-the-lung-safe-study
#13
Giacomo Bellani, John G Laffey, Tài Pham, Fabiana Madotto, Eddy Fan, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Vesna Bumbasirevic, Lise Piquilloud, Frank van Haren, Anders Larsson, Daniel F McAuley, Philippe R Bauer, Yaseen M Arabi, Marco Ranieri, Massimo Antonelli, Gordon D Rubenfeld, B Taylor Thompson, Hermann Wrigge, Arthur S Slutsky, Antonio Pesenti
RATIONALE: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse. OBJECTIVES: To determine whether, during NIV, the categorization of ARDS severity based on the PaO2/FiO2 Berlin criteria is useful. METHODS: The LUNG SAFE (Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) study described the management of patients with ARDS...
January 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27704150/intensive-care-medicine-in-2050-the-future-of-icu-treatments
#14
EDITORIAL
Jean-Louis Vincent, Arthur S Slutsky, Luciano Gattinoni
No abstract text is available yet for this article.
October 4, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27620284/improved-survival-in-critically-ill-patients-are-large-rcts-more-useful-than-personalized-medicine-we-are-not-sure
#15
EDITORIAL
Luciano Gattinoni, Tommaso Tonetti, Michael Quintel
No abstract text is available yet for this article.
November 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27515158/will-all-ards-patients-be-receiving-mechanical-ventilation-in-2035-we-are-not-sure
#16
EDITORIAL
Michael Quintel, Tommaso Tonetti, Luciano Gattinoni
No abstract text is available yet for this article.
April 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/27481739/how-safe-is-gelatin-a-systematic-review-and-meta-analysis-of-gelatin-containing-plasma-expanders-vs-crystalloids-and-albumin
#17
Claudia Moeller, Carolin Fleischmann, Daniel Thomas-Rueddel, Vlasislav Vlasakov, Bram Rochwerg, Philip Theurer, Luciano Gattinoni, Konrad Reinhart, Christiane S Hartog
Gelatin is a widely used synthetic colloid resuscitation fluid. We undertook a systematic review and meta-analysis of adverse effects in randomized and nonrandomized studies comparing gelatin with crystalloid or albumin for treatment of hypovolemia. Multiple databases were searched systematically without language restrictions until August 2015. We assessed risk of bias of individual studies and certainty in evidence assessment by the Grading of Recommendations Assessment, Development, and Evaluation approach...
October 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27467273/role-of-albumin-starches-and-gelatins-versus-crystalloids-in-volume-resuscitation-of-critically-ill-patients
#18
Luca Zazzeron, Luciano Gattinoni, Pietro Caironi
PURPOSE OF REVIEW: The review focuses on fluid resuscitation of critically ill patients with either colloid or crystalloid solutions. RECENT FINDINGS: In healthy patients, the volume expanding effect of colloids is greater than that of crystalloids. However, in critically ill patients, a similar amount of crystalloids and colloids is required for fluid resuscitation, suggesting a lower efficiency of colloids when capillary permeability is increased, and endothelial glycocalyx disrupted...
October 2016: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/27448607/assessment-of-oxygenation-response-to-prone-position-ventilation-in-ards-by-lung-ultrasonography
#19
EDITORIAL
Claude Guerin, Luciano Gattinoni
No abstract text is available yet for this article.
October 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27447787/real-time-urinary-electrolyte-monitoring-after-furosemide-administration-in-surgical-icu-patients-with-normal-renal-function
#20
Luca Zazzeron, Davide Ottolina, Eleonora Scotti, Michele Ferrari, Paola Bruzzone, Silvio Sibilla, Cristina Marenghi, Luciano Gattinoni, Pietro Caironi
BACKGROUND: Although the loop-diuretic furosemide is widely employed in critically ill patients with known long-term effects on plasma electrolytes, accurate data describing its acute effects on renal electrolyte handling and the generation of plasma electrolyte alterations are lacking. We hypothesized that the long-term effects of furosemide on plasma electrolytes and acid-base depend on its immediate effects on electrolyte excretion rate and patient clinical baseline characteristics...
December 2016: Annals of Intensive Care
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