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EDITORIAL
Luciano Gattinoni, Francesca Collino, Luigi Camporota
No abstract text is available yet for this article.
March 27, 2024: Intensive Care Medicine
#2
JOURNAL ARTICLE
Simone Gattarello, Fabio Lombardo, Federica Romitti, Rosanna D'Albo, Mara Velati, Isabella Fratti, Tommaso Pozzi, Rosmery Nicolardi, Antonio Fioccola, Mattia Busana, Francesca Collino, Peter Herrmann, Luigi Camporota, Michael Quintel, Onnen Moerer, Leif Saager, Konrad Meissner, Luciano Gattinoni
BACKGROUND: The individual components of mechanical ventilation may have distinct effects on kidney perfusion and on the risk of developing acute kidney injury; we aimed to explore ventilatory predictors of acute kidney failure and the hemodynamic changes consequent to experimental high-power mechanical ventilation. METHODS: Secondary analysis of two animal studies focused on the outcomes of different mechanical power settings, including 78 pigs mechanically ventilated with high mechanical power for 48 h...
March 21, 2024: Intensive Care Medicine Experimental
#3
JOURNAL ARTICLE
Lorenzo Giosa, Francesco Zadek, Mattia Busana, Giovanna De Simone, Serena Brusatori, Martin Krbec, František Duška, Paolo Brambilla, Alberto Zanella, Alessandra Di Masi, Pietro Caironi, Emanuele Perez, Luciano Gattinoni, Thomas Langer
It is commonly assumed that changes in plasma strong ion difference (SID) result in equal changes in whole-blood base excess (BE). However, at varying pH, albumin ionic-binding and transerythrocyte shifts alter the SID of plasma without affecting that of whole-blood (SIDwb ), i.e. , the BE. We hypothesize that, during acidosis, 1) an expected plasma SID (SIDexp ) reflecting electrolytes redistribution can be predicted from albumin and hemoglobin's charges, and 2) only deviations in SID from SIDexp reflect changes in SIDwb , and therefore, BE...
February 29, 2024: Journal of Applied Physiology
#4
JOURNAL ARTICLE
Antonio Fioccola, Tommaso Pozzi, Isabella Fratti, Rosmery Valentina Nicolardi, Federica Romitti, Mattia Busana, Francesca Collino, Luigi Camporota, Konrad Meissner, Onnen Moerer, Luciano Gattinoni
INTRODUCTION: The use of the pulmonary artery catheter has decreased overtime; central venous blood gases are generally used in place of mixed venous samples. We want to evaluate the accuracy of oxygen and carbon dioxide related parameters from a central versus a mixed venous sample, and whether this difference is influenced by mechanical ventilation. MATERIALS AND METHODS: We analyzed 78 healthy female piglets ventilated with different mechanical power. RESULTS: There was a significant difference in oxygen-derived parameters between samples taken from the central venous and mixed venous blood (S <mml:math xmlns:mml="https://www...
February 2024: Physiological Reports
#5
JOURNAL ARTICLE
Antonio Fioccola, Rosmery Valentina Nicolardi, Tommaso Pozzi, Isabella Fratti, Federica Romitti, Francesca Collino, Verena Reupke, Gianluigi Li Bassi, Alessandro Protti, Alessandro Santini, Massimo Cressoni, Mattia Busana, Onnen Moerer, Luigi Camporota, Luciano Gattinoni
INTRODUCTION: Lung weight is an important study endpoint to assess lung edema in porcine experiments on acute respiratory distress syndrome and ventilatory induced lung injury. Evidence on the relationship between lung-body weight relationship is lacking in the literature. The aim of this work is to provide a reference equation between normal lung and body weight in female domestic piglets. MATERIALS AND METHODS: 177 healthy female domestic piglets from previous studies were included in the analysis...
January 26, 2024: Intensive Care Medicine Experimental
#6
EDITORIAL
Luciano Gattinoni, Francesca Collino, Luigi Camporota
No abstract text is available yet for this article.
January 3, 2024: Intensive Care Medicine
#7
EDITORIAL
Christian Putensen, Luciano Gattinoni, Steffen Leonhardt
No abstract text is available yet for this article.
December 1, 2023: Anesthesiology
#8
JOURNAL ARTICLE
Mattia Busana, Anna Rau, Stefano Lazzari, Simone Gattarello, Massimo Cressoni, Lorenz Biggemann, Lars-Olav Harnisch, Lorenzo Giosa, Andreas Vogt, Leif Saager, Joachim Lotz, Birgit Meller, Konrad Meissner, Luciano Gattinoni, Onnen Moerer
BACKGROUND: Despite the fervent scientific effort, a state-of-the art assessment of the different causes of hypoxemia (shunt, ventilation-perfusion mismatch and diffusion limitation) in COVID-19 ARDS is currently lacking. In this study we aimed to understand what is the relative contribution of the different mechanisms of hypoxemia in this disease and what is their relationship with the distribution of tissue and blood within the lung. METHODS: We prospectively enrolled 10 patients with COVID-19 ARDS, intubated for <7 days...
September 1, 2023: Anesthesiology
#9
EDITORIAL
Luciano Gattinoni, Giuseppe Citerio, Arthur S Slutsky
No abstract text is available yet for this article.
October 2023: Intensive Care Medicine
#10
JOURNAL ARTICLE
Luciano Gattinoni
Control of Breathing Using an Extracorporeal Membrane Lung. By T Kolobow, L Gattinoni, TA Tomlinson, JE Pierce. Anesthesiology 1977; 46:138-41. Reprinted with permission. Body Position Changes Redistribute Lung Computed-Tomographic Density in Patients with Acute Respiratory Failure. By L Gattinoni, P Pelosi, G Vitale, A Pesenti, L D'Andrea, D Mascheroni. Anesthesiology 1991; 74:15-23. Reprinted with permission. Dr. Gattinoni's scientific career was primarily driven by curiosity. His generation was not formally trained, but he was part of a community of young and enthusiastic colleagues who were forging a new discipline: intensive care medicine...
September 1, 2023: Anesthesiology
#11
JOURNAL ARTICLE
Rosanna D'Albo, Federica Romitti, Luigi Camporota, Onnen Moerer, Mattia Busana, Luciano Gattinoni
The conditions of temperature, pressure and saturation in which respiratory gas volumes are expressed (STPD, ATPS or BTPS) are physiologically relevant, but often ignored or unknown in clinical practice. In this study we aimed to investigate whether and at which extent the gas volumes corrections, either in natural and artificial lung, may alter key respiratory and metabolic variables and the possible clinical consequences. We primarily referred to the effects of gas volumes corrections on three physiological variables: physiological dead space, venous admixture and total VCO2 during extracorporeal support...
June 22, 2023: Journal of Applied Physiology
#12
JOURNAL ARTICLE
Giacomo Grasselli, Carolyn S Calfee, Luigi Camporota, Daniele Poole, Marcelo B P Amato, Massimo Antonelli, Yaseen M Arabi, Francesca Baroncelli, Jeremy R Beitler, Giacomo Bellani, Geoff Bellingan, Bronagh Blackwood, Lieuwe D J Bos, Laurent Brochard, Daniel Brodie, Karen E A Burns, Alain Combes, Sonia D'Arrigo, Daniel De Backer, Alexandre Demoule, Sharon Einav, Eddy Fan, Niall D Ferguson, Jean-Pierre Frat, Luciano Gattinoni, Claude Guérin, Margaret S Herridge, Carol Hodgson, Catherine L Hough, Samir Jaber, Nicole P Juffermans, Christian Karagiannidis, Jozef Kesecioglu, Arthur Kwizera, John G Laffey, Jordi Mancebo, Michael A Matthay, Daniel F McAuley, Alain Mercat, Nuala J Meyer, Marc Moss, Laveena Munshi, Sheila N Myatra, Michelle Ng Gong, Laurent Papazian, Bhakti K Patel, Mariangela Pellegrini, Anders Perner, Antonio Pesenti, Lise Piquilloud, Haibo Qiu, Marco V Ranieri, Elisabeth Riviello, Arthur S Slutsky, Renee D Stapleton, Charlotte Summers, Taylor B Thompson, Carmen S Valente Barbas, Jesús Villar, Lorraine B Ware, Björn Weiss, Fernando G Zampieri, Elie Azoulay, Maurizio Cecconi
The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to adult patients and to non-pharmacological respiratory support strategies across different aspects of acute respiratory distress syndrome (ARDS), including ARDS due to coronavirus disease 2019 (COVID-19). These guidelines were formulated by an international panel of clinical experts, one methodologist and patients' representatives on behalf of the ESICM...
June 16, 2023: Intensive Care Medicine
#13
LETTER
Serena Brusatori, Carmelo Zinnato, Tommaso Pozzi, Luigi Camporota, John J Marini, Luciano Gattinoni
No abstract text is available yet for this article.
September 1, 2023: American Journal of Respiratory and Critical Care Medicine
#14
JOURNAL ARTICLE
Tommaso Pozzi, Francesca Collino, Serena Brusatori, Federica Romitti, Mattia Busana, Onnen Moerer, Luigi Camporota, Davide Chiumello, Silvia Coppola, Luciano Gattinoni
No abstract text is available yet for this article.
June 13, 2023: American Journal of Respiratory and Critical Care Medicine
#15
JOURNAL ARTICLE
Luigi Camporota, Barnaby Sanderson, Stephanie Worrall, Marlies Ostermann, Nicholas A Barrett, Andrew Retter, Mattia Busana, Patrick Collins, Federica Romitti, Beverley J Hunt, Louise Rose, Luciano Gattinoni, Davide Chiumello
BACKGROUND: Despite its diagnostic and prognostic importance, physiologic dead space fraction is not included in the current ARDS definition or severity classification. ARDS caused by COVID-19 (C-ARDS) is characterized by increased physiologic dead space fraction and hypoxemia. Our aim was to investigate the relationship between dead space indices, markers of inflammation, immunothrombosis, severity and intensive care unit (ICU) mortality. RESULTS: Retrospective data including demographics, gas exchange, ventilatory parameters, and respiratory mechanics in the first 24 h of invasive ventilation...
April 26, 2023: Journal of Critical Care
#16
REVIEW
John J Marini, Lauren T Thornton, Patricia R M Rocco, Luciano Gattinoni, Philip S Crooke
At the bedside, assessing the risk of ventilator-induced lung injury (VILI) requires parameters readily measured by the clinician. For this purpose, driving pressure (DP) and end-inspiratory static 'plateau' pressure ([Formula: see text]) of the tidal cycle are unquestionably useful but lack key information relating to associated volume changes and cumulative strain. 'Mechanical power', a clinical term which incorporates all dissipated ('non-elastic') and conserved ('elastic') energy components of inflation, has drawn considerable interest as a comprehensive 'umbrella' variable that accounts for the influence of ventilating frequency per minute as well as the energy cost per tidal cycle...
April 20, 2023: Critical Care: the Official Journal of the Critical Care Forum
#17
JOURNAL ARTICLE
Mara Velati, Rosanna D'Albo, Serena Brusatori, Fabio Lombardo, Roberta Maj, Carmelo Zinnato, Simone Gattarello, Mattia Busana, Federica Romitti, Onnen Moerer, Konrad Meissner, Luciano Gattinoni
COVID-19 pandemic has seen an unprecedented number of patients presenting with acute respiratory distress syndrome to the intensive care units all over the world. Between August and November 2022, we performed research on PubMed screening all publications on COVID-19 disease and respiratory failure and its treatment. In this review we focused on COVID-19 most common manifestations concerning lung function. The respiratory infection develops in three broad phases: early, intermediate, and late. The mainstay of the disease is the frequent presence of severe hypoxemia associated - at least at the beginning - to a near normal lung mechanics and PaCO<inf>2</inf> tension...
March 31, 2023: Minerva Anestesiologica
#18
EDITORIAL
Luciano Gattinoni, Francesca Collino, Luigi Camporota
No abstract text is available yet for this article.
April 2023: Intensive Care Medicine
#19
RANDOMIZED CONTROLLED TRIAL
Serena Brusatori, Carmelo Zinnato, Mattia Busana, Federica Romitti, Simone Gattarello, Maria Michela Palumbo, Tommaso Pozzi, Irene Steinberg, Paola Palermo, Stefano Lazzari, Roberta Maj, Mara Velati, Rosanna D'Albo, Jona Wassong, Killian Meissner, Fabio Lombardo, Peter Herrmann, Michael Quintel, Onnen Moerer, Luigi Camporota, John J Marini, Konrad Meissner, Luciano Gattinoni
Rationale: In the EOLIA (ECMO to Rescue Lung Injury in Severe ARDS) trial, oxygenation was similar between intervention and conventional groups, whereas [Formula: see text]e was reduced in the intervention group. Comparable reductions in ventilation intensity are theoretically possible with low-flow extracorporeal CO2 removal (ECCO2 R), provided oxygenation remains acceptable. Objectives: To compare the effects of ECCO2 R and extracorporeal membrane oxygenation (ECMO) on gas exchange, respiratory mechanics, and hemodynamics in animal models of pulmonary (intratracheal hydrochloric acid) and extrapulmonary (intravenous oleic acid) lung injury...
May 1, 2023: American Journal of Respiratory and Critical Care Medicine
#20
JOURNAL ARTICLE
Robert H Bartlett, Jean Carlet, Deborah Cook, Luciano Gattinoni, Maurene Harvey, Judith Jacobi, Margaret M Parker, Charles L Sprung, Peter Suter, Ann Thompson, Jean-Louis Vincent
On the 50th anniversary of the Society of Critical Care Medicine's journal Critical Care Medicine, critical care pioneers reflect on the importance of the journal to their careers and to the development of the field of adult and pediatric critical care.
February 1, 2023: Critical Care Medicine
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