Claudia Dorado-Martínez, Enrique Montiel-Flores, Jose Luis Ordoñez-Librado, Ana Luisa Gutierrez-Valdez, Cesar Alfonso Garcia-Caballero, Javier Sanchez-Betancourt, Leonardo Reynoso-Erazo, Rocio Tron-Alvarez, Vianey Rodríguez-Lara, Maria Rosa Avila-Costa
BACKGROUND: Previous work from our group has shown that chronic exposure to Vanadium pentoxide (V2O5) causes cytoskeletal alterations suggesting that V2O5 can interact with cytoskeletal proteins through polymerization and tyrosine phosphatases inhibition, causing Alzheimer's disease (AD)-like hippocampal cell death. OBJECTIVE: This work aims to characterize an innovative AD experimental model through chronic V2O5 inhalation, analyzing the spatial memory alterations and the presence of neurofibrillary tangles (NFTs), amyloid-β (Aβ) senile plaques, cerebral amyloid angiopathy, and dendritic spine loss in AD-related brain structures...
April 12, 2024: Journal of Alzheimer's Disease: JAD