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https://www.readbyqxmd.com/read/28317499/a-multi-country-study-of-harms-to-children-because-of-others-drinking
#1
Anne-Marie Laslett, Georgia Rankin, Orratai Waleewong, Sarah Callinan, Hanh T M Hoang, Ramon Florenzano, Siri Hettige, Isidore Obot, Latsamy Siengsounthone, Akanidomo Ibanga, Ann Hope, Jonas Landberg, Hanh T M Vu, Thaksaphon Thamarangsi, Dag Rekve, Robin Room
OBJECTIVE: This study aims to ascertain and compare the prevalence and correlates of alcohol-related harms to children cross-nationally. METHOD: National and regional sample surveys of randomly selected households included 7,848 carers (4,223 women) from eight countries (Australia, Chile, Ireland, Lao People's Democratic Republic [PDR], Nigeria, Sri Lanka, Thailand, and Vietnam). Country response rates ranged from 35% to 99%. Face-to-face or telephone surveys asking about harm from others' drinking to children ages 0-17 years were conducted, including four specific harms: that because of others' drinking in the past year children had been (a) physically hurt, (b) verbally abused, (c) exposed to domestic violence, or (d) left unsupervised...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28302408/narcolepsy-and-hypersomnia-in-norwegian-children-and-young-adults-following-the-influenza-a-h1n1-2009-pandemic
#2
Lill Trogstad, Inger Johanne Bakken, Nina Gunnes, Sara Ghaderi, Camilla Stoltenberg, Per Magnus, Siri E Håberg
BACKGROUND: Associations between influenza infection and sleep disorders are poorly studied. We investigated if pandemic influenza infection or vaccination with Pandemrix in 2009/2010 was associated with narcolepsy or hypersomnia in children and young adults. METHODS: We followed the Norwegian population under age 30 from January 2008 through December 2012 by linking national health registry data. Narcolepsy diagnoses were validated using hospital records. Risks of narcolepsy or hypersomnia were estimated as adjusted hazard ratios (HRs) in Cox regression models with influenza infection and vaccination as time-dependent exposures...
March 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28251181/maternal-immunoreactivity-to-herpes-simplex-virus-2-and-risk-of-autism-spectrum-disorder-in-male-offspring
#3
Milada Mahic, Siri Mjaaland, Hege Marie Bøvelstad, Nina Gunnes, Ezra Susser, Michaeline Bresnahan, Anne-Siri Øyen, Bruce Levin, Xiaoyu Che, Deborah Hirtz, Ted Reichborn-Kjennerud, Synnve Schjølberg, Christine Roth, Per Magnus, Camilla Stoltenberg, Pål Surén, Mady Hornig, W Ian Lipkin
Maternal infections during pregnancy are associated with risk of neurodevelopmental disorders, including autism spectrum disorders (ASDs). Proposed pathogenetic mechanisms include fetal infection, placental inflammation, and maternal cytokines or antibodies that cross the placenta. The Autism Birth Cohort comprises mothers, fathers, and offspring recruited in Norway in 1999 to 2008. Through questionnaire screening, referrals, and linkages to a national patient registry, 442 mothers of children with ASD were identified, and 464 frequency-matched controls were selected...
January 2017: MSphere
https://www.readbyqxmd.com/read/28166806/the-we-study-does-botulinum-toxin-a-make-walking-easier-in-children-with-cerebral-palsy-study-protocol-for-a-randomized-controlled-trial
#4
Siri Merete Brændvik, Karin Roeleveld, Guro Lillemoen Andersen, Anne Elisabeth Ross Raftemo, Kjersti Ramstad, Jasmina Majkic-Tajsic, Torarin Lamvik, Bendik Lund, Turid Follestad, Torstein Vik
BACKGROUND: Intramuscular injections of botulinum toxin A (BoNT-A) have been a cornerstone in the treatment of spasticity for the last 20 years. In Norway, the treatment is now offered to two out of three children with spastic cerebral palsy (CP). However, despite its common use, the evidence for its functional effects is limited and inconclusive. The objective of this study is to determine whether BoNT-A makes walking easier in children with CP. We hypothesize that injections with BoNT-A in the calf muscles will reduce energy cost during walking, improve walking capacity, increase habitual physical activity, reduce pain and improve self-perceived performance and satisfaction...
February 6, 2017: Trials
https://www.readbyqxmd.com/read/28007925/long-term-maintenance-of-the-influenza-specific-cross-reactive-memory-cd4-t-cell-responses-following-repeated-annual-influenza-vaccination
#5
Mai-Chi Trieu, Fan Zhou, Sarah Lartey, Åsne Jul-Larsen, Siri Mjaaland, Saranya Sridhar, Rebecca Jane Cox
Background.: Annual vaccination for healthcare workers and other high-risk groups is the mainstay of the public health strategy to combat influenza. Inactivated influenza vaccines confer protection by inducing neutralizing antibodies efficiently against homologous and closely matched virus strains. In the absence of neutralizing antibodies, cross-reactive T cells have been shown to limit disease severity. However, animal studies and a study in immunocompromised children suggested that repeated vaccination hampers CD8+ T cells...
March 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27935163/manipulating-tablets-and-capsules-given-to-hospitalised-children-in-norway-is-common-practice
#6
Kathrin Bjerknes, Silje Bøyum, Solveig Kristensen, Jørgen Brustugun, Siri Wang
AIM: This study provided an overview of manipulating oral medicines given to hospitalised children and evaluated this practice in two hospitals. It focused on the type of manipulation and the dosage forms that were manipulated. METHOD: This was a cross-sectional, prospective study, carried out on the paediatric wards at two Norwegian hospitals for four weeks in 2013. A medicine was said to have been manipulated if it was not administered as described in the Norwegian summary of product characteristics...
December 9, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27887572/maternal-smoking-impacts-key-biological-pathways-in-newborns-through-epigenetic-modification-in-utero
#7
Daniel M Rotroff, Bonnie R Joubert, Skylar W Marvel, Siri E Håberg, Michael C Wu, Roy M Nilsen, Per M Ueland, Wenche Nystad, Stephanie J London, Alison Motsinger-Reif
BACKGROUND: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend evaluation of individual CpGs to gene-level and pathway-level analyses among 1062 participants in the Norwegian Mother and Child Cohort Study (MoBa) using the Illumina 450 K platform to measure methylation in newborn DNA and maternal smoking in pregnancy, assessed using the biomarker, plasma cotinine...
November 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27885805/school-absenteeism-among-school-aged-children-with-medically-attended-acute-viral-respiratory-illness-during-three-influenza-seasons-2012-2013-through-2014-2015
#8
Huong Q McLean, Siri H Peterson, Jennifer P King, Jennifer K Meece, Edward A Belongia
BACKGROUND: Acute respiratory illnesses (ARIs) are common in school-aged children, but few studies have assessed school absenteeism due to specific respiratory viruses. OBJECTIVE: Evaluate school absenteeism among children with medically attended ARI due to common viruses. METHODS: We analyzed follow-up surveys from children seeking care for acute respiratory illness who were enrolled in the influenza vaccine effectiveness study at Marshfield Clinic during the 2012-2013 through 2014-2015 influenza seasons...
November 25, 2016: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/27871640/multidimensional-influences-on-autism-symptom%C3%A2-measures-implications-for-use-in%C3%A2-etiological-research
#9
Karoline Alexandra Havdahl, Vanessa Hus Bal, Marisela Huerta, Andrew Pickles, Anne-Siri Øyen, Camilla Stoltenberg, Catherine Lord, Somer L Bishop
OBJECTIVE: Growing awareness that symptoms of autism spectrum disorder (ASD) transcend multiple diagnostic categories, and major advances in the identification of genetic syndromes associated with ASD, have led to widespread use of ASD symptom measures in etiologic studies of neurodevelopmental disorders. Insufficient consideration of potentially confounding factors such as cognitive ability or behavior problems can have important negative consequences in interpretation of findings, including erroneous estimation of associations between ASD and etiologic factors...
December 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27866223/circulating-microrna-levels-predict-residual-beta-cell-function-and-glycaemic-control-in-children-with-type-1-diabetes-mellitus
#10
Nasim Samandari, Aashiq H Mirza, Lotte B Nielsen, Simranjeet Kaur, Philip Hougaard, Siri Fredheim, Henrik B Mortensen, Flemming Pociot
AIMS/HYPOTHESIS: We aimed to identify circulating microRNA (miRNA) that predicts clinical progression in a cohort of 123 children with new-onset type 1 diabetes mellitus. METHODS: Plasma samples were prospectively obtained at 1, 3, 6, 12 and 60 months after diagnosis from a subset of 40 children from the Danish Remission Phase Cohort, and profiled for miRNAs. At the same time points, meal-stimulated C-peptide and HbA1c levels were measured and insulin-dose adjusted HbA1c (IDAA1c) calculated...
February 2017: Diabetologia
https://www.readbyqxmd.com/read/27824595/pre-eclampsia-and-childhood-asthma
#11
Maria C Magnus, Siri E Håberg, Per Magnus, Anders Engeland, Per Nafstad, Øystein Karlstad, Wenche Nystad
Studies of pre-eclampsia and childhood asthma are conflicting, and none have performed a formal mediation analysis of preterm birth.We examined the association between pre-eclampsia and asthma at 7 years using national registries, including all births in Norway from 1999 to 2006 (n=406 907), and a subsample of children in the Norwegian Mother and Child Cohort Study (MoBa) (n=45 028) using log-linear regression. We performed a mediation analysis of preterm birth, and a sibling comparison to evaluate unobserved confounding...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27714809/physical-compatibility-of-total-parenteral-nutrition-and-drugs-in-y-site-administration-to-children-from-neonates-to-adolescents
#12
Vigdis Staven, Herra Iqbal, Siri Wang, Ingrid Grønlie, Ingunn Tho
OBJECTIVES: Infusion of precipitate or destabilized emulsion can be harmful. The purpose of this study was to obtain Y-site compatibility data on intravenous drugs and total parenteral nutrition (TPN) relevant for children. METHODS: Two three-in-one TPN admixtures (Olimel N5E and Numeta G16E) used for children of different age groups were tested with ten drugs (ampicillin, ceftazidime, clindamycin, dexamethasone, fluconazole, fosphenytoin, furosemide, metronidazole, ondansetron and paracetamol)...
April 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27590471/comorbidities-treated-in-primary-care-in-children-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-nationwide-registry-linkage-study-from-norway
#13
Inger J Bakken, Kari Tveito, Kari M Aaberg, Sara Ghaderi, Nina Gunnes, Lill Trogstad, Per Magnus, Camilla Stoltenberg, Siri E Håberg
BACKGROUND: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex condition. Causal factors are not established, although underlying psychological or immunological susceptibility has been proposed. We studied primary care diagnoses for children with CFS/ME, with children with another hospital diagnosis (type 1 diabetes mellitus [T1DM]) and the general child population as comparison groups. METHODS: All Norwegian children born 1992-2012 constituted the study sample...
2016: BMC Family Practice
https://www.readbyqxmd.com/read/27518161/maternal-folate-intake-during-pregnancy-and-childhood-asthma-in-a-population-based-cohort
#14
Christine L Parr, Maria C Magnus, Øystein Karlstad, Margaretha Haugen, Helga Refsum, Per M Ueland, Adrian McCann, Per Nafstad, Siri E Håberg, Wenche Nystad, Stephanie J London
RATIONALE: A potential adverse effect of high folate intake during pregnancy on children's asthma development remains controversial. OBJECTIVES: To prospectively investigate folate intake from both food and supplements during pregnancy and asthma at age seven years when the diagnosis is more reliable than at preschool age. METHODS: This study included eligible children born 2002-2006 from the Norwegian Mother and Child Cohort Study, a population-based pregnancy cohort, linked to the Norwegian Prescription Database...
August 12, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27489297/stronger-and-more-vulnerable-a-balanced-view-of-the-impacts-of-the-nicu-experience-on-parents
#15
Annie Janvier, John Lantos, Judy Aschner, Keith Barrington, Beau Batton, Daniel Batton, Siri Fuglem Berg, Brian Carter, Deborah Campbell, Felicia Cohn, Anne Drapkin Lyerly, Dan Ellsbury, Avroy Fanaroff, Jonathan Fanaroff, Kristy Fanaroff, Sophie Gravel, Marlyse Haward, Stefan Kutzsche, Neil Marlow, Martha Montello, Nathalie Maitre, Joshua T Morris, Odd G Paulsen, Trisha Prentice, Alan R Spitzer
For parents, the experience of having an infant in the NICU is often psychologically traumatic. No parent can be fully prepared for the extreme stress and range of emotions of caring for a critically ill newborn. As health care providers familiar with the NICU, we thought that we understood the impact of the NICU on parents. But we were not prepared to see the children in our own families as NICU patients. Here are some of the lessons our NICU experience has taught us. We offer these lessons in the hope of helping health professionals consider a balanced view of the NICU's impact on families...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27482059/comorbidity-and-childhood-epilepsy-a-nationwide-registry-study
#16
Kari Modalsli Aaberg, Inger Johanne Bakken, Morten I Lossius, Camilla Lund Søraas, Siri Eldevik Håberg, Camilla Stoltenberg, Pål Surén, Richard Chin
BACKGROUND AND OBJECTIVE: Children with epilepsy are at increased risk of other disorders and difficulties, preceding, cooccurring with, or after the diagnosis of epilepsy. Risk estimates vary, few studies are population-based, and few provide comprehensive assessments of comorbidities. We used nationwide registry data to describe frequencies of medical, neurologic, developmental, and psychiatric conditions occurring before and after children are diagnosed with childhood epilepsy. METHODS: Data were obtained from the Norwegian Patient Registry, which is an administrative database recording International Classification of Diseases, 10th Revision diagnoses from all government-funded specialist health services in Norway (outpatient consultations and hospitalizations)...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27334565/off-label-and-unlicensed-medicines-to-hospitalised-children-in-norway
#17
Arna Teigen, Siri Wang, Bich Thuy Truong, Kathrin Bjerknes
OBJECTIVES: The aim of this study was to investigate the use of off-label (OL) and unlicensed (UL) medicines to hospitalised children in Norway, to add to the current knowledge on use of medicines in this vulnerable patient group. METHODS: The study was performed as a cross-sectional prospective study. Medication was classified as on- or off-label based on the comparison with the SmPC regarding age, indication, dosage, route of administration and handling of the product...
April 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27294404/elevated-blood-eosinophils-in-early-infancy-are-predictive-for-atopic-dermatitis-in-children-with-risk-for-atopy
#18
Siri Rossberg, Kerstin Gerhold, Thomas Geske, Kurt Zimmermann, Georg Menke, Mohammad Zaino, Ulrich Wahn, Eckard Hamelmann, Susanne Lau
BACKGROUND: Accessible markers to predict the development of atopic diseases are highly desirable but yet matter of debate. OBJECTIVE: We investigated the role of blood eosinophils at 4 weeks and 7 months of life and their association with developing atopic dermatitis (AD) in a birth cohort of children with atopic heredity. METHODS: Infant blood samples for eosinophil counts were taken from 559 infants at 4 weeks and from 467 infants at 7 month of life with at least one atopic parent...
June 13, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27221136/maternal-plasma-total-neopterin-and-kynurenine-tryptophan-levels-during-pregnancy-in-relation-to-asthma-development-in-the-offspring
#19
Maria C Magnus, Øystein Karlstad, Øivind Midtun, Siri E Håberg, Gro Tunheim, Christine L Parr, Per Nafstad, Stephanie J London, Roy M Nilsen, Per M Ueland, Wenche Nystad
BACKGROUND: Neopterin levels and kynurenine/tryptophan ratios (KTRs) increase with IFN-γ stimulation, indicating TH1 immunity, and thus might be inversely associated with asthma. OBJECTIVE: We sought to examine the association of maternal neopterin levels and KTRs during pregnancy with asthma in the offspring. METHODS: We analyzed the associations of maternal plasma total neopterin levels and KTRs in midpregnancy with asthma at age 7 years among 2883 children in the Norwegian Mother and Child Cohort Study...
November 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27044585/effects-of-exercise-intensity-and-nutrition-advice-on-myocardial-function-in-obese-children-and-adolescents-a-multicentre-randomised-controlled-trial-study-protocol
#20
RANDOMIZED CONTROLLED TRIAL
Katrin A Dias, Jeff S Coombes, Daniel J Green, Sjaan R Gomersall, Shelley E Keating, Arnt Erik Tjonna, Siri Marte Hollekim-Strand, Mansoureh Sadat Hosseini, Torstein Baade Ro, Margrete Haram, Else Marie Huuse, Peter S W Davies, Peter A Cain, Gary M Leong, Charlotte B Ingul
INTRODUCTION: The prevalence of paediatric obesity is increasing, and with it, lifestyle-related diseases in children and adolescents. High-intensity interval training (HIIT) has recently been explored as an alternate to traditional moderate-intensity continuous training (MICT) in adults with chronic disease and has been shown to induce a rapid reversal of subclinical disease markers in obese children and adolescents. The primary aim of this study is to compare the effects of HIIT with MICT on myocardial function in obese children and adolescents...
April 4, 2016: BMJ Open
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