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SIRI in childrens

Vigdis Staven, Herra Iqbal, Siri Wang, Ingrid Grønlie, Ingunn Tho
OBJECTIVES: Infusion of precipitate or destabilized emulsion can be harmful. The purpose of this study was to obtain Y-site compatibility data on intravenous drugs and total parenteral nutrition (TPN) relevant for children. METHODS: Two three-in-one TPN admixtures (Olimel N5E and Numeta G16E) used for children of different age groups were tested with ten drugs (ampicillin, ceftazidime, clindamycin, dexamethasone, fluconazole, fosphenytoin, furosemide, metronidazole, ondansetron and paracetamol)...
October 7, 2016: Journal of Pharmacy and Pharmacology
Inger J Bakken, Kari Tveito, Kari M Aaberg, Sara Ghaderi, Nina Gunnes, Lill Trogstad, Per Magnus, Camilla Stoltenberg, Siri E Håberg
BACKGROUND: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex condition. Causal factors are not established, although underlying psychological or immunological susceptibility has been proposed. We studied primary care diagnoses for children with CFS/ME, with children with another hospital diagnosis (type 1 diabetes mellitus [T1DM]) and the general child population as comparison groups. METHODS: All Norwegian children born 1992-2012 constituted the study sample...
2016: BMC Family Practice
Christine L Parr, Maria C Magnus, Øystein Karlstad, Margaretha Haugen, Helga Refsum, Per M Ueland, Adrian McCann, Per Nafstad, Siri E Håberg, Wenche Nystad, Stephanie J London
RATIONALE: A potential adverse effect of high folate intake during pregnancy on children's asthma development remains controversial. OBJECTIVES: To prospectively investigate folate intake from both food and supplements during pregnancy and asthma at age seven years when the diagnosis is more reliable than at preschool age. METHODS: This study included eligible children born 2002-2006 from the Norwegian Mother and Child Cohort Study, a population-based pregnancy cohort, linked to the Norwegian Prescription Database...
August 12, 2016: American Journal of Respiratory and Critical Care Medicine
Annie Janvier, John Lantos, Judy Aschner, Keith Barrington, Beau Batton, Daniel Batton, Siri Fuglem Berg, Brian Carter, Deborah Campbell, Felicia Cohn, Anne Drapkin Lyerly, Dan Ellsbury, Avroy Fanaroff, Jonathan Fanaroff, Kristy Fanaroff, Sophie Gravel, Marlyse Haward, Stefan Kutzsche, Neil Marlow, Martha Montello, Nathalie Maitre, Joshua T Morris, Odd G Paulsen, Trisha Prentice, Alan R Spitzer
For parents, the experience of having an infant in the NICU is often psychologically traumatic. No parent can be fully prepared for the extreme stress and range of emotions of caring for a critically ill newborn. As health care providers familiar with the NICU, we thought that we understood the impact of the NICU on parents. But we were not prepared to see the children in our own families as NICU patients. Here are some of the lessons our NICU experience has taught us. We offer these lessons in the hope of helping health professionals consider a balanced view of the NICU's impact on families...
September 2016: Pediatrics
Kari Modalsli Aaberg, Inger Johanne Bakken, Morten I Lossius, Camilla Lund Søraas, Siri Eldevik Håberg, Camilla Stoltenberg, Pål Surén, Richard Chin
BACKGROUND AND OBJECTIVE: Children with epilepsy are at increased risk of other disorders and difficulties, preceding, cooccurring with, or after the diagnosis of epilepsy. Risk estimates vary, few studies are population-based, and few provide comprehensive assessments of comorbidities. We used nationwide registry data to describe frequencies of medical, neurologic, developmental, and psychiatric conditions occurring before and after children are diagnosed with childhood epilepsy. METHODS: Data were obtained from the Norwegian Patient Registry, which is an administrative database recording International Classification of Diseases, 10th Revision diagnoses from all government-funded specialist health services in Norway (outpatient consultations and hospitalizations)...
September 2016: Pediatrics
Arna Teigen, Siri Wang, Bich Thuy Truong, Kathrin Bjerknes
OBJECTIVES: The aim of this study was to investigate the use of off-label (OL) and unlicensed (UL) medicines to hospitalised children in Norway, to add to the current knowledge on use of medicines in this vulnerable patient group. METHODS: The study was performed as a cross-sectional prospective study. Medication was classified as on- or off-label based on the comparison with the SmPC regarding age, indication, dosage, route of administration and handling of the product...
June 23, 2016: Journal of Pharmacy and Pharmacology
Siri Rossberg, Kerstin Gerhold, Thomas Geske, Kurt Zimmermann, Georg Menke, Mohammad Zaino, Ulrich Wahn, Eckard Hamelmann, Susanne Lau
BACKGROUND: Accessible markers to predict the development of atopic diseases are highly desirable but yet matter of debate. OBJECTIVE: We investigated the role of blood eosinophils at 4 weeks and 7 months of life and their association with developing atopic dermatitis (AD) in a birth cohort of children with atopic heredity. METHODS: Infant blood samples for eosinophil counts were taken from 559 infants at 4 weeks and from 467 infants at 7 month of life with at least one atopic parent...
June 13, 2016: Pediatric Allergy and Immunology
Maria C Magnus, Øystein Karlstad, Øivind Midtun, Siri E Håberg, Gro Tunheim, Christine L Parr, Per Nafstad, Stephanie J London, Roy M Nilsen, Per M Ueland, Wenche Nystad
BACKGROUND: Neopterin levels and kynurenine/tryptophan ratios (KTRs) increase with IFN-γ stimulation, indicating TH1 immunity, and thus might be inversely associated with asthma. OBJECTIVE: We sought to examine the association of maternal neopterin levels and KTRs during pregnancy with asthma in the offspring. METHODS: We analyzed the associations of maternal plasma total neopterin levels and KTRs in midpregnancy with asthma at age 7 years among 2883 children in the Norwegian Mother and Child Cohort Study...
April 20, 2016: Journal of Allergy and Clinical Immunology
Katrin A Dias, Jeff S Coombes, Daniel J Green, Sjaan R Gomersall, Shelley E Keating, Arnt Erik Tjonna, Siri Marte Hollekim-Strand, Mansoureh Sadat Hosseini, Torstein Baade Ro, Margrete Haram, Else Marie Huuse, Peter S W Davies, Peter A Cain, Gary M Leong, Charlotte B Ingul
INTRODUCTION: The prevalence of paediatric obesity is increasing, and with it, lifestyle-related diseases in children and adolescents. High-intensity interval training (HIIT) has recently been explored as an alternate to traditional moderate-intensity continuous training (MICT) in adults with chronic disease and has been shown to induce a rapid reversal of subclinical disease markers in obese children and adolescents. The primary aim of this study is to compare the effects of HIIT with MICT on myocardial function in obese children and adolescents...
2016: BMJ Open
Bonnie R Joubert, Janine F Felix, Paul Yousefi, Kelly M Bakulski, Allan C Just, Carrie Breton, Sarah E Reese, Christina A Markunas, Rebecca C Richmond, Cheng-Jian Xu, Leanne K Küpers, Sam S Oh, Cathrine Hoyo, Olena Gruzieva, Cilla Söderhäll, Lucas A Salas, Nour Baïz, Hongmei Zhang, Johanna Lepeule, Carlos Ruiz, Symen Ligthart, Tianyuan Wang, Jack A Taylor, Liesbeth Duijts, Gemma C Sharp, Soesma A Jankipersadsing, Roy M Nilsen, Ahmad Vaez, M Daniele Fallin, Donglei Hu, Augusto A Litonjua, Bernard F Fuemmeler, Karen Huen, Juha Kere, Inger Kull, Monica Cheng Munthe-Kaas, Ulrike Gehring, Mariona Bustamante, Marie José Saurel-Coubizolles, Bilal M Quraishi, Jie Ren, Jörg Tost, Juan R Gonzalez, Marjolein J Peters, Siri E Håberg, Zongli Xu, Joyce B van Meurs, Tom R Gaunt, Marjan Kerkhof, Eva Corpeleijn, Andrew P Feinberg, Celeste Eng, Andrea A Baccarelli, Sara E Benjamin Neelon, Asa Bradman, Simon Kebede Merid, Anna Bergström, Zdenko Herceg, Hector Hernandez-Vargas, Bert Brunekreef, Mariona Pinart, Barbara Heude, Susan Ewart, Jin Yao, Nathanaël Lemonnier, Oscar H Franco, Michael C Wu, Albert Hofman, Wendy McArdle, Pieter Van der Vlies, Fahimeh Falahi, Matthew W Gillman, Lisa F Barcellos, Ashish Kumar, Magnus Wickman, Stefano Guerra, Marie-Aline Charles, John Holloway, Charles Auffray, Henning W Tiemeier, George Davey Smith, Dirkje Postma, Marie-France Hivert, Brenda Eskenazi, Martine Vrijheid, Hasan Arshad, Josep M Antó, Abbas Dehghan, Wilfried Karmaus, Isabella Annesi-Maesano, Jordi Sunyer, Akram Ghantous, Göran Pershagen, Nina Holland, Susan K Murphy, Dawn L DeMeo, Esteban G Burchard, Christine Ladd-Acosta, Harold Snieder, Wenche Nystad, Gerard H Koppelman, Caroline L Relton, Vincent W V Jaddoe, Allen Wilcox, Erik Melén, Stephanie J London
Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip...
April 7, 2016: American Journal of Human Genetics
Svenn-Erik Mamelund, Bjørn Haneberg, Siri Mjaaland
Background.  Reanalysis of influenza survey data from 1918 to 1919 was done to obtain new insights into the geographic and host factors responsible for the various waves. Methods.  We analyzed the age- and sex-specific influenza morbidity, fatality, and mortality for the city of Baltimore and smaller towns and rural areas of Maryland and the city of Bergen (Norway), using survey data. The Maryland surveys captured the 1918 fall wave, whereas the Bergen survey captured 3 waves during 1918-1919. Results.  Morbidity in rural areas of Maryland was higher than in the city of Baltimore during the fall of 1918, that was almost equal to that in Bergen during the summer of 1918...
January 2016: Open Forum Infectious Diseases
Kathryn M Magruder, Nancy Kassam-Adams, Siri Thoresen, Miranda Olff
BACKGROUND: The field of trauma and traumatic stress is dominated by studies on treatments for those who experience adversity from traumatic experiences. While this is important, we should not neglect the opportunity to consider trauma in a public health perspective. Such a perspective will help to develop prevention approaches as well as extend the reach of early interventions and treatments. The purpose of this paper is to provide an introduction to a public health approach to trauma and traumatic stress and identify key opportunities for trauma professionals and our professional societies (such as the International Society for Traumatic Stress Studies [ISTSS] and the European Society for Traumatic Stress Studies [ESTSS]) to increase our societal impact by adopting such an approach...
2016: European Journal of Psychotraumatology
Berit Feiring, Ida Laake, Tor Molden, Siri E Håberg, Hanne Nøkleby, Siri Schøyen Seterelv, Per Magnus, Lill Trogstad
BACKGROUND: Selective immunisation is an alternative to universal vaccination if children at increased risk of disease can be identified. Within the Norwegian Childhood Immunisation Programme, BCG vaccine against tuberculosis and vaccine against hepatitis B virus (HBV) are offered only to children with parents from countries with high burden of the respective disease. We wanted to study whether this selective immunisation policy reaches the targeted groups. METHODS: The study population was identified through the Norwegian Central Population Registry and consisted of all children born in Norway 2007-2010 and residing in Norway until their second birthday, in total 240,484 children...
April 12, 2016: Vaccine
Grith Lærkholm Hansen, Pia Foli-Andersen, Siri Fredheim, Claus Juhl, Line Sofie Remvig, Martin H Rose, Ivana Rosenzweig, Sándor Beniczky, Birthe Olsen, Kasper Pilgaard, Jesper Johannesen
BACKGROUND: The purpose of this study was to explore the possible difference in the electroencephalogram (EEG) pattern between euglycemia and hypoglycemia in children with type 1 diabetes (T1D) during daytime and during sleep. The aim is to develop a hypoglycemia alarm based on continuous EEG measurement and real-time signal processing. METHOD: Eight T1D patients aged 6-12 years were included. A hyperinsulinemic hypoglycemic clamp was performed to induce hypoglycemia both during daytime and during sleep...
February 25, 2016: Journal of Diabetes Science and Technology
Maria C Magnus, Øystein Karlstad, Siri E Håberg, Per Nafstad, George Davey Smith, Wenche Nystad
BACKGROUND: Paracetamol exposure has been positively associated with asthma development. The relative importance of prenatal vs infant exposure and confounding by indication remains elusive. We examined the association of prenatal and infant (first 6 months) paracetamol exposure with asthma development while addressing confounding by indication. METHODS: We used information from the Norwegian Mother and Child Cohort Study, including 53169 children for evaluation of current asthma at 3 years, 25394 for current asthma at 7 years and 45607 for dispensed asthma medications at 7 years in the Norwegian Prescription Database...
April 2016: International Journal of Epidemiology
Anne-Siri Fismen, Otto Robert Frans Smith, Torbjørn Torsheim, Mette Rasmussen, Trine Pedersen Pagh, Lilly Augustine, Kristiina Ojala, Oddrun Samdal
BACKGROUND: In the Nordic countries, substantial policy and intervention efforts have been made to increase adolescents' consumption of fruit and vegetables and to reduce their intake of sweets and soft drinks. Some initiatives have been formulated in a Nordic collaboration and implemented at national level. In recent years, social inequalities in food habits have been attracted particular governmental interest and several initiatives addressing the socioeconomic gradient in food habits have been highlighted...
2016: PloS One
Siri Thoresen, Tine K Jensen, Tore Wentzel-Larsen, Grete Dyb
BACKGROUND AND AIMS: Little is known about parents' health following their children's exposure to trauma. We investigated the mental health of parents of young terrorist survivors and assessed parental distress and guilt as potential predictors of mental health. METHOD: Mothers and fathers (N=531) participated in two study waves 4-5 and 14-15 months after the shooting. Posttraumatic stress reactions (PTSS) and anxiety/depression were compared with age- and gender-adjusted expected scores that were calculated from a concurrent population study...
March 2016: Journal of Anxiety Disorders
Ellen J Schafer, Natalie A Williams, Siri Digney, Marion E Hare, Sato Ashida
BACKGROUND: Infant feeding takes place within a network of social relationships. However, the social context in which infant feeding advice is received remains underresearched. OBJECTIVE: The objective of this study was to evaluate the social contexts of infant feeding by examining individual and relationship characteristics of mothers and network members associated with advice to exclusively breastfeed, exclusively formula feed, or use a combination of breast milk and formula...
February 2016: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
Jonas F Ludvigsson, Siri E Håberg, Gun Peggy Knudsen, Pierre Lafolie, Helga Zoega, Catharina Sarkkola, Stephanie von Kraemer, Elisabete Weiderpass, Mette Nørgaard
National health care registries in the Nordic countries share many attributes, but different legal and ethical frameworks represent a challenge to promoting effective joint research. Internationally, there is a lack of knowledge about how ethical matters are considered in Nordic registry-based research, and a lack of knowledge about how Nordic ethics committees operate and what is needed to obtain an approval. In this paper, we review ethical aspects of registry-based research, the legal framework, the role of ethics review boards in the Nordic countries, and the structure of the ethics application...
2015: Clinical Epidemiology
Eva Kirkhus, Linda Z Arvidsson, Hans-Jørgen Smith, Berit Flatø, Siri O Hetlevik, Tore A Larheim
BACKGROUND: MRI manifestation of temporomandibular joint arthritis is frequently reported in children with juvenile idiopathic arthritis. However, little attention has been paid to temporomandibular joint disk abnormalities. OBJECTIVE: To assess combinations of MRI findings in the symptomatic temporomandibular joint in children with juvenile idiopathic arthritis with focus on disk abnormalities. MATERIALS AND METHODS: This was a retrospective study of 46 patients with juvenile idiopathic arthritis, mean age 12 years (range: 5-17 years)...
March 2016: Pediatric Radiology
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