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SIRI in childrens

Nathaly M Sweeney, Shareef A Nahas, Shimul Chowdhury, Miguel Del Campo, Marilyn C Jones, David P Dimmock, Stephen F Kingsmore, Rcigm Investigators
Congenital diaphragmatic hernia (CDH) results from incomplete formation of the diaphragm leading to herniation of abdominal organs into the thoracic cavity. CDH is associated with pulmonary hypoplasia, congenital heart disease and pulmonary hypertension. Genetically, it is associated with aneuploidies, chromosomal copy number variants, and single gene mutations. CDH is the most expensive non-cardiac congenital defect: Management frequently requires implementation of Extracorporeal Membrane Oxygenation (ECMO), which increases management expenditures 2...
March 16, 2018: Cold Spring Harbor Molecular Case Studies
Hogne Vikanes Buchvold, Ståle Pallesen, Siri Waage, Bjørn Bjorvatn
Objectives The aim of this study was to investigate changes in body mass index (BMI) between different work schedules and different average number of yearly night shifts over a four-year follow-up period. Methods A prospective study of Norwegian nurses (N=2965) with different work schedules was conducted: day only, two-shift rotation (day and evening shifts), three-shift rotation (day, evening and night shifts), night only, those who changed towards night shifts, and those who changed away from schedules containing night shifts...
January 7, 2018: Scandinavian Journal of Work, Environment & Health
Charlotte B Ingul, Katrin A Dias, Arnt E Tjonna, Turid Follestad, Mansoureh S Hosseini, Anita S Timilsina, Siri M Hollekim-Strand, Torstein B Ro, Peter S W Davies, Peter A Cain, Gary M Leong, Jeff S Coombes
BACKGROUND: High intensity interval training (HIIT) confers superior cardiovascular health benefits to moderate intensity continuous training (MICT) in adults and may be efficacious for improving diminished cardiac function in obese children. The aim of this study was to compare the effects of HIIT, MICT and nutrition advice interventions on resting left ventricular (LV) peak systolic tissue velocity (S') in obese children. METHODS: Ninety-nine obese children were randomised into one of three 12-week interventions, 1) HIIT [n = 33, 4 × 4 min bouts at 85-95% maximum heart rate (HR max ), 3 times/week] and nutrition advice, 2) MICT [n = 32, 44 mins at 60-70% HR max , 3 times/week] and nutrition advice, and 3) nutrition advice only (nutrition) [n = 34]...
February 13, 2018: Progress in Cardiovascular Diseases
Siri E Håberg, Kari M Aaberg, Pål Surén, Lill Trogstad, Sara Ghaderi, Camilla Stoltenberg, Per Magnus, Inger Johanne Bakken
OBJECTIVES: To determine if pandemic influenza vaccination was associated with an increased risk of epilepsy in children. METHODS: Information from Norwegian registries from 2006 through 2014 on all children <18 years living in Norway on October 1, 2009 was used in Cox regression models to estimate hazard ratios for incident epilepsy after vaccination. A self-controlled case series analysis was used to estimate incidence rate ratios in defined risk periods after pandemic vaccination...
February 15, 2018: Pediatrics
Illja Diets, Esmé Waanders, Marjolijn J L Ligtenberg, Diede van Bladel, Eveline J Kamping, Peter M Hoogerbrugge, Saskia Hopman, Maran J W Olderode-Berends, Erica H Gerkes, David Koolen, Carlo Marcelis, Gijs We Santen, Martine van Belzen, Dylan Mordaunt, Lesley McGregor, Elizabeth Thompson, Antonis Kattamis, Agata Pastorczak, Wojciech Mlynarski, Denisa Ilencikova, Anneke Vulto-van Silfhout, Thatjana Gardeitchik, E S J M de Bont, Jan Loeffen, Anja Wagner, Arjen R Mensenkamp, Roland P Kuiper, Nicoline Hoogerbrugge, Marjolijn Jongmans
PURPOSE: In many children with cancer and characteristics suggestive of a genetic predisposition syndrome, the genetic cause is still unknown. We studied the yield of pathogenic mutations by applying whole exome sequencing on a selected cohort of children with cancer. EXPERIMENTAL DESIGN: To identify mutations in known and novel cancer predisposing genes, we performed trio-based whole exome sequencing on germline DNA of 40 selected children and their parents. These children were diagnosed with cancer and had at least one of the following features: (1) intellectual disability and/or congenital anomalies, (2) multiple malignancies, (3) family history of cancer or (4) an adult type of cancer...
January 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Ming Hui Chen, Sangita Choudhury, Mami Hirata, Siri Khalsa, Bernard Chang, Christopher A Walsh
The frequency and gender distribution of thoracic aortic aneurysm as a cardiovascular manifestation of loss-of-function (LOF) X-linked FilaminA (FLNA) mutations are not known. Furthermore, there is very limited cardiovascular morbidity or mortality data in children and adults. We analyzed cardiac data on the largest series of 114 patients with LOF FLNA mutations, both children and adults, with periventricular nodular heterotopia (PVNH), including 48 study patients and 66 literature patients, median age of 22...
February 2018: American Journal of Medical Genetics. Part A
JaHun Kim, Semret Nicodimos, Siri E Kushner, Isaac C Rhew, Elizabeth McCauley, Ann Vander Stoep
BACKGROUND: To compare the mental health status of children of immigrant (COI) and non-immigrant (NI) parents and to determine whether differences in mental health status between COI and NI vary across 4 racial/ethnic groups. METHODS: We conducted universal mental health screening of 2374 sixth graders in an urban public school district. To screen, we administered well-validated adolescent depression and disruptive behavior problem questionnaires. We evaluated associations between child mental health, parent immigration status, and race/ethnicity using binomial regression...
February 2018: Journal of School Health
Ana Isabel Gutiérrez Hervás, Ernesto Cortés Castell, Mercedes Juste Ruíz, Vicente Gil Guillén, María Mercedes Rizo Baeza
INTRODUCTION: It seems relevant to analyze the body composition in the early childhood. However, there is not an agreement in the protocol to assess body composition in this age range/group. OBJECTIVE: To determine the most useful equation to estimate the body fat percentage that preschool children contain and the utility of the waist-to-height ratio to determine abdominal obesity. METHODS: We measured (weight, height, waist circumference and skinfolds) in 285 children aged 2 to 7 years old...
November 17, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jon Magnus Haga, Siri Thoresen, Lise Eilin Stene, Tore Wentzel-Larsen, Grete Dyb
OBJECTIVES: To assess changes in parents' short-term and long-term primary and specialised healthcare consumption following a terrorist attack threatening the lives of their children. DESIGN: Registry-based study comparing parental healthcare service consumption in the 3 years before and the 3 years after a terrorist attack. SETTING: The aftermath of the Utøya terrorist attack. The regular, publicly funded, universal healthcare system in Norway...
December 21, 2017: BMJ Open
Siri Sahib S Khalsa, Ndi Geh, Bryn A Martin, Philip A Allen, Jennifer Strahle, Francis Loth, Desale Habtzghi, Aintzane Urbizu Serrano, Daniel McQuaide, Hugh J L Garton, Karin M Muraszko, Cormac O Maher
OBJECTIVE Chiari malformation Type I (CM-I) is typically defined on imaging by a cerebellar tonsil position ≥ 5 mm below the foramen magnum. Low cerebellar tonsil position is a frequent incidental finding on brain or cervical spine imaging, even in asymptomatic individuals. Nonspecific symptoms (e.g., headache and neck pain) are common in those with low tonsil position as well as in those with normal tonsil position, leading to uncertainty regarding appropriate management for many patients with low tonsil position and nonspecific symptoms...
November 10, 2017: Journal of Neurosurgery. Pediatrics
Katrin A Dias, Charlotte B Ingul, Arnt E Tjønna, Shelley E Keating, Sjaan R Gomersall, Turid Follestad, Mansoureh S Hosseini, Siri M Hollekim-Strand, Torstein B Ro, Margrete Haram, Else Marie Huuse, Peter S W Davies, Peter A Cain, Gary M Leong, Jeff S Coombes
BACKGROUND: Paediatric obesity significantly increases the risk of developing cardiometabolic diseases across the lifespan. Increasing cardiorespiratory fitness (CRF) could mitigate this risk. High-intensity interval training (HIIT) improves CRF in clinical adult populations but the evidence in paediatric obesity is inconsistent. OBJECTIVES: The objectives of this study were to determine the efficacy of a 12-week, HIIT intervention for increasing CRF and reducing adiposity in children with obesity...
August 29, 2017: Sports Medicine
Robert Ternik, Fang Liu, Jeremy A Bartlett, Yuet Mei Khong, David Cheng Thiam Tan, Trupti Dixit, Siri Wang, Elizabeth A Galella, Zhihui Gao, Sandra Klein
The acceptability of pediatric pharmaceutical products to patients and their caregivers can have a profound impact on the resulting therapeutic outcome. However, existing methodology and approaches used for acceptability assessments for pediatric products is fragmented, making robust and consistent product evaluations difficult. A pediatric formulation development workshop took place in Washington, DC in June 2016 through the University of Maryland's Center of Excellence in Regulatory Science and Innovation (M-CERSI)...
August 24, 2017: International Journal of Pharmaceutics
Milada Mahic, Xiaoyu Che, Ezra Susser, Bruce Levin, Ted Reichborn-Kjennerud, Per Magnus, Camilla Stoltenberg, Lokendrasingh Chauhan, Thomas Briese, Michaeline Bresnahan, Pål Surén, Mady Hornig, Siri Mjaaland, W Ian Lipkin
The literature concerning gestational maternal influenza virus infection and risk of autism spectrum disorders (ASD) is inconclusive. To address this uncertainty, we obtained information from questionnaires and samples from the Autism Birth Cohort, a prospective birth cohort comprising mothers, fathers, and offspring recruited in Norway in 1999 to 2008. Through questionnaires, referrals, and linkages to the Norwegian National Patient Registry, we identified 338 mothers of children with ASD and 348 frequency-matched controls for whom plasma samples that had been collected midpregnancy and after delivery were available for influenza virus serology via luciferase immunoprecipitation and hemagglutinin inhibition assays for influenza virus strains circulating during the study period...
May 2017: MSphere
Karoline Alexandra Havdahl, Somer L Bishop, Pål Surén, Anne-Siri Øyen, Catherine Lord, Andrew Pickles, Stephen von Tetzchner, Synnve Schjølberg, Nina Gunnes, Mady Hornig, W Ian Lipkin, Ezra Susser, Michaeline Bresnahan, Per Magnus, Nina Stenberg, Ted Reichborn-Kjennerud, Camilla Stoltenberg
The parental report-based Autism Diagnostic Interview-Revised (ADI-R) and the clinician observation-based Autism Diagnostic Observation Schedule (ADOS) have been validated primarily in U.S. clinics specialized in autism spectrum disorder (ASD), in which most children are referred by their parents because of ASD concern. This study assessed diagnostic agreement of the ADOS-2 and ADI-R toddler algorithms in a more broadly based sample of 679 toddlers (age 35-47 months) from the Norwegian Mother and Child Cohort...
October 2017: Autism Research: Official Journal of the International Society for Autism Research
Melina Mgongo, Nikolas A S Chotta, Tamara H Hashim, Jacqueline G Uriyo, Damian J Damian, Babill Stray-Pedersen, Sia E Msuya, Margareta Wandel, Siri Vangen
This study assessed the prevalence and risk factors associated with underweight, stunting and wasting among children aged 0-24 months in six districts of Kilimanjaro region, northern Tanzania. A cross-sectional population-based study using a multistage, proportionate to size sampling was conducted from June 2010 to March 2011. A structured questionnaire was used to collect sociodemographic, economic, feeding and child information. Anthropometric data were collected by trained field workers, and the data were used to assess child nutritional status...
May 10, 2017: International Journal of Environmental Research and Public Health
Øystein Karlstad, Kari Furu, Camilla Stoltenberg, Siri E Håberg, Inger Johanne Bakken
BACKGROUND: Studies from several countries have reported that children youngest in grade are at higher risk of attention-deficit/hyperactivity disorder (ADHD) diagnosis and treatment. Norwegian children start school the year they turn six, making children born in December youngest in their grade. We used data on medication, specialist healthcare diagnoses, and primary healthcare diagnoses from national registers to investigate associations between birth month and ADHD. METHODS: All children born in Norway between 1998 and 2006 ( N=509,827) were followed from age six until 31 December 2014...
June 2017: Scandinavian Journal of Public Health
Jennifer L Dembinski, Adane Mihret, Solomon A Yimer, Bamlak Tessema, Mai-Chi Trieu, Azeb Tarekegn, Nahom Getachew, Rebecca J Cox, Fredrik Oftung, Bjørn Haneberg, Abraham Aseffa, Siri Mjaaland
BACKGROUND: Influenza in children who reside in tropical and subtropical regions has until recently been regarded as insignificant. However, new evidence suggests that it significantly impacts hospitalization and promotes secondary bacterial coinfections. Ethiopia is situated in a subtropical area where influenza viruses are likely to circulate year round. METHODS: Clinical data were recorded in a cohort of 103 healthy preschool children recruited in Addis Ababa, Ethiopia...
2017: Open Forum Infectious Diseases
Solveig Fadnes, Morten Smedsrud Wigen, Siri Ann Nyrnes, Lasse Lovstakken
Two-dimensional blood speckle tracking (ST) has shown promise for measuring complex flow patterns in neonatal hearts using linear arrays and high-frame-rate plane wave imaging. For general pediatric applications, however, the need for phased array probes emerges due to the limited intercostal acoustic window available. In this paper, a clinically approved real-time duplex imaging setup with phased array probes was used to investigate the potential of blood ST for the 2-D vector flow imaging of children with congenital heart disease...
September 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Anne-Marie Laslett, Georgia Rankin, Orratai Waleewong, Sarah Callinan, Hanh T M Hoang, Ramon Florenzano, Siri Hettige, Isidore Obot, Latsamy Siengsounthone, Akanidomo Ibanga, Ann Hope, Jonas Landberg, Hanh T M Vu, Thaksaphon Thamarangsi, Dag Rekve, Robin Room
OBJECTIVE: This study aims to ascertain and compare the prevalence and correlates of alcohol-related harms to children cross-nationally. METHOD: National and regional sample surveys of randomly selected households included 7,848 carers (4,223 women) from eight countries (Australia, Chile, Ireland, Lao People's Democratic Republic [PDR], Nigeria, Sri Lanka, Thailand, and Vietnam). Country response rates ranged from 35% to 99%. Face-to-face or telephone surveys asking about harm from others' drinking to children ages 0-17 years were conducted, including four specific harms: that because of others' drinking in the past year children had been (a) physically hurt, (b) verbally abused, (c) exposed to domestic violence, or (d) left unsupervised...
March 2017: Journal of Studies on Alcohol and Drugs
Lill Trogstad, Inger Johanne Bakken, Nina Gunnes, Sara Ghaderi, Camilla Stoltenberg, Per Magnus, Siri E Håberg
BACKGROUND: Associations between influenza infection and sleep disorders are poorly studied. We investigated if pandemic influenza infection or vaccination with Pandemrix in 2009/2010 was associated with narcolepsy or hypersomnia in children and young adults. METHODS: We followed the Norwegian population under age 30 from January 2008 through December 2012 by linking national health registry data. Narcolepsy diagnoses were validated using hospital records. Risks of narcolepsy or hypersomnia were estimated as adjusted hazard ratios (HRs) in Cox regression models with influenza infection and vaccination as time-dependent exposures...
April 4, 2017: Vaccine
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