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https://www.readbyqxmd.com/read/29784756/clinical-features-of-children-with-autism-who-passed-18-month-screening
#1
Roald A Øien, Synnve Schjølberg, Fred R Volkmar, Frederick Shic, Domenic V Cicchetti, Anders Nordahl-Hansen, Nina Stenberg, Mady Hornig, Alexandra Havdahl, Anne-Siri Øyen, Pamela Ventola, Ezra S Susser, Martin R Eisemann, Katarzyna Chawarska
OBJECTIVES: We compared sex-stratified developmental and temperamental profiles at 18 months in children screening negative for autism spectrum disorder (ASD) on the Modified Checklist for Autism in Toddlers (M-CHAT) but later receiving diagnoses of ASD (false-negative group) versus those without later ASD diagnoses (true-negative group). METHODS: We included 68 197 screen-negative cases from the Norwegian Mother and Child Cohort Study (49.1% girls). Children were screened by using the 6 critical items of the M-CHAT at 18 months...
May 21, 2018: Pediatrics
https://www.readbyqxmd.com/read/29760300/workaholism-and-negative-work-related-incidents-among-nurses
#2
Cecilie Schou Andreassen, Ståle Pallesen, Bente E Moen, Bjørn Bjorvatn, Siri Waage, Wilmar B Schaufeli
The present study comprised 1,781 nurses who participated in an investigation about working conditions, sleep, and health. They answered a questionnaire about age, sex, marital status, children living at home, work hours per week, number of night shifts last year, and total sleep duration and that also included a validated instrument assessing workaholism. In addition, they were asked to report on eight items concerning negative work-related incidents (dozed off at work, dozed while driving, harmed or nearly harmed self, harmed or nearly harmed patients/others, and harmed or nearly harmed equipment)...
May 15, 2018: Industrial Health
https://www.readbyqxmd.com/read/29722838/vitamin-a-and-d-intake-in-pregnancy-infant-supplementation-and-asthma-development-the-norwegian-mother-and-child-cohort
#3
Christine L Parr, Maria C Magnus, Øystein Karlstad, Kristin Holvik, Nicolai A Lund-Blix, Margareta Haugen, Christian M Page, Per Nafstad, Per M Ueland, Stephanie J London, Siri E Håberg, Wenche Nystad
Background: Western diets may provide excess vitamin A, which is potentially toxic and could adversely affect respiratory health and counteract benefits from vitamin D. Objective: The aim of this study was to examine child asthma at age 7 y in relation to maternal intake of vitamins A and D during pregnancy, infant supplementation with these vitamins, and their potential interaction. Design: We studied 61,676 school-age children (born during 2002-2007) from the Norwegian Mother and Child Cohort with data on maternal total (food and supplement) nutrient intake in pregnancy (food-frequency questionnaire validated against biomarkers) and infant supplement use at age 6 mo (n = 54,142 children)...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29650804/exploring-variation-in-glycemic-control-across-and-within-eight-high-income-countries-a-cross-sectional-analysis-of-64-666-children-and-adolescents-with-type-1-diabetes
#4
Dimitrios Charalampopoulos, Julia M Hermann, Jannet Svensson, Torild Skrivarhaug, David M Maahs, Karin Akesson, Justin T Warner, Reinhard W Holl, Niels H Birkebæk, Ann K Drivvoll, Kellee M Miller, Ann-Marie Svensson, Terence Stephenson, Sabine E Hofer, Siri Fredheim, Siv J Kummernes, Nicole Foster, Lena Hanberger, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Knut Dahl-Jørgensen, Mark Clements, Ragnar Hanas
OBJECTIVE: International studies on childhood type 1 diabetes (T1D) have focused on whole-country mean HbA1c levels, thereby concealing potential variations within countries. We aimed to explore the variations in HbA1c across and within eight high-income countries to best inform international benchmarking and policy recommendations. RESEARCH DESIGN AND METHODS: Data were collected between 2013 and 2014 from 64,666 children with T1D who were <18 years of age across 528 centers in Germany, Austria, England, Wales, US, Sweden, Denmark, and Norway...
April 12, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29566668/oral-medicine-acceptance-in-infants-and-toddlers-measurement-properties-of-the-caregiver-administered-children-s-acceptance-tool-carecat
#5
Joern Blume, Ana Lorena Ruano, Siri Wang, Debra J Jackson, Thorkild Tylleskär, Liv Inger Strand
BACKGROUND: Developing age-appropriate medications remains a challenge in particular for the population of infants and toddlers, as they are not able to reliably self-report if they would accept and consequently take an oral medicine. Therefore, it is common to use caregivers as proxies when assessing medicine acceptance. The outcome measures used in this research field differ and most importantly lack validation, implying a persisting gap in knowledge and controversy in the field. The newly developed Caregiver-administered Children's Acceptance Tool (CareCAT) is based on a 5-point nominal scale, with descriptors of medication acceptance behavior...
March 22, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29549119/the-case-for-early-use-of-rapid-whole-genome-sequencing-in-management-of-critically-ill-infants-late-diagnosis-of-coffin-siris-syndrome-in-an-infant-with-left-congenital-diaphragmatic-hernia-congenital-heart-disease-and-recurrent-infections
#6
Nathaly M Sweeney, Shareef A Nahas, Shimul Chowdhury, Miguel Del Campo, Marilyn C Jones, David P Dimmock, Stephen F Kingsmore, Rcigm Investigators
Congenital diaphragmatic hernia (CDH) results from incomplete formation of the diaphragm leading to herniation of abdominal organs into the thoracic cavity. CDH is associated with pulmonary hypoplasia, congenital heart disease and pulmonary hypertension. Genetically, it is associated with aneuploidies, chromosomal copy number variants, and single gene mutations. CDH is the most expensive non-cardiac congenital defect: Management frequently requires implementation of Extracorporeal Membrane Oxygenation (ECMO), which increases management expenditures 2...
March 16, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29487940/shift-work-schedule-and-night-work-load-effects-on-body-mass-index-a-four-year-longitudinal-study
#7
Hogne Vikanes Buchvold, Ståle Pallesen, Siri Waage, Bjørn Bjorvatn
Objectives The aim of this study was to investigate changes in body mass index (BMI) between different work schedules and different average number of yearly night shifts over a four-year follow-up period. Methods A prospective study of Norwegian nurses (N=2965) with different work schedules was conducted: day only, two-shift rotation (day and evening shifts), three-shift rotation (day, evening and night shifts), night only, those who changed towards night shifts, and those who changed away from schedules containing night shifts...
May 1, 2018: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/29452134/effect-of-high-intensity-interval-training-on-cardiac-function-in-children-with-obesity-a-randomised-controlled-trial
#8
REVIEW
Charlotte B Ingul, Katrin A Dias, Arnt E Tjonna, Turid Follestad, Mansoureh S Hosseini, Anita S Timilsina, Siri M Hollekim-Strand, Torstein B Ro, Peter S W Davies, Peter A Cain, Gary M Leong, Jeff S Coombes
BACKGROUND: High intensity interval training (HIIT) confers superior cardiovascular health benefits to moderate intensity continuous training (MICT) in adults and may be efficacious for improving diminished cardiac function in obese children. The aim of this study was to compare the effects of HIIT, MICT and nutrition advice interventions on resting left ventricular (LV) peak systolic tissue velocity (S') in obese children. METHODS: Ninety-nine obese children were randomised into one of three 12-week interventions, 1) HIIT [n = 33, 4 × 4 min bouts at 85-95% maximum heart rate (HRmax ), 3 times/week] and nutrition advice, 2) MICT [n = 32, 44 min at 60-70% HRmax , 3 times/week] and nutrition advice, and 3) nutrition advice only (nutrition) [n = 34]...
February 13, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29449342/epilepsy-in-children-after-pandemic-influenza-vaccination
#9
Siri E Håberg, Kari M Aaberg, Pål Surén, Lill Trogstad, Sara Ghaderi, Camilla Stoltenberg, Per Magnus, Inger Johanne Bakken
OBJECTIVES: To determine if pandemic influenza vaccination was associated with an increased risk of epilepsy in children. METHODS: Information from Norwegian registries from 2006 through 2014 on all children <18 years living in Norway on October 1, 2009 was used in Cox regression models to estimate hazard ratios for incident epilepsy after vaccination. A self-controlled case series analysis was used to estimate incidence rate ratios in defined risk periods after pandemic vaccination...
February 15, 2018: Pediatrics
https://www.readbyqxmd.com/read/29351919/high-yield-of-pathogenic-germline-mutations-causative-or-likely-causative-of-the-cancer-phenotype-in-selected-children-with-cancer
#10
Illja J Diets, Esmé Waanders, Marjolijn J Ligtenberg, Diede A G van Bladel, Eveline J Kamping, Peter M Hoogerbrugge, Saskia Hopman, Maran J Olderode-Berends, Erica H Gerkes, David A Koolen, Carlo Marcelis, Gijs W Santen, Martine J van Belzen, Dylan Mordaunt, Lesley McGregor, Elizabeth Thompson, Antonis Kattamis, Agata Pastorczak, Wojciech Mlynarski, Denisa Ilencikova, Anneke Vulto- van Silfhout, Thatjana Gardeitchik, Eveline S de Bont, Jan Loeffen, Anja Wagner, Arjen R Mensenkamp, Roland P Kuiper, Nicoline Hoogerbrugge, Marjolijn C Jongmans
Purpose: In many children with cancer and characteristics suggestive of a genetic predisposition syndrome, the genetic cause is still unknown. We studied the yield of pathogenic mutations by applying whole-exome sequencing on a selected cohort of children with cancer. Experimental Design: To identify mutations in known and novel cancer-predisposing genes, we performed trio-based whole-exome sequencing on germline DNA of 40 selected children and their parents. These children were diagnosed with cancer and had at least one of the following features: (1) intellectual disability and/or congenital anomalies, (2) multiple malignancies, (3) family history of cancer, or (4) an adult type of cancer...
April 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29334594/thoracic-aortic-aneurysm-in-patients-with-loss-of-function-filamin-a-mutations-clinical-characterization-genetics-and-recommendations
#11
Ming Hui Chen, Sangita Choudhury, Mami Hirata, Siri Khalsa, Bernard Chang, Christopher A Walsh
The frequency and gender distribution of thoracic aortic aneurysm as a cardiovascular manifestation of loss-of-function (LOF) X-linked FilaminA (FLNA) mutations are not known. Furthermore, there is very limited cardiovascular morbidity or mortality data in children and adults. We analyzed cardiac data on the largest series of 114 patients with LOF FLNA mutations, both children and adults, with periventricular nodular heterotopia (PVNH), including 48 study patients and 66 literature patients, median age of 22...
February 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29333640/comparing-mental-health-of-us-children-of-immigrants-and-non-immigrants-in-4-racial-ethnic-groups
#12
JaHun Kim, Semret Nicodimos, Siri E Kushner, Isaac C Rhew, Elizabeth McCauley, Ann Vander Stoep
BACKGROUND: To compare the mental health status of children of immigrant (COI) and non-immigrant (NI) parents and to determine whether differences in mental health status between COI and NI vary across 4 racial/ethnic groups. METHODS: We conducted universal mental health screening of 2374 sixth graders in an urban public school district. To screen, we administered well-validated adolescent depression and disruptive behavior problem questionnaires. We evaluated associations between child mental health, parent immigration status, and race/ethnicity using binomial regression...
February 2018: Journal of School Health
https://www.readbyqxmd.com/read/29280643/estimation-of-body-fat-among-2-to-7-year-old-spanish-children-by-different-skinfolds-equations-and-waist-to-height-ratio
#13
Ana Isabel Gutiérrez Hervás, Ernesto Cortés Castell, Mercedes Juste Ruíz, Vicente Gil Guillén, María Mercedes Rizo Baeza
INTRODUCTION: It seems relevant to analyze the body composition in the early childhood. However, there is not an agreement in the protocol to assess body composition in this age range/group. OBJECTIVE: To determine the most useful equation to estimate the body fat percentage that preschool children contain and the utility of the waist-to-height ratio to determine abdominal obesity. METHODS: We measured (weight, height, waist circumference and skinfolds) in 285 children aged 2 to 7 years old...
November 17, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29273662/healthcare-to-parents-of-young-terrorism-survivors-a-registry-based-study-in-norway
#14
Jon Magnus Haga, Siri Thoresen, Lise Eilin Stene, Tore Wentzel-Larsen, Grete Dyb
OBJECTIVES: To assess changes in parents' short-term and long-term primary and specialised healthcare consumption following a terrorist attack threatening the lives of their children. DESIGN: Registry-based study comparing parental healthcare service consumption in the 3 years before and the 3 years after a terrorist attack. SETTING: The aftermath of the Utøya terrorist attack. The regular, publicly funded, universal healthcare system in Norway...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29125445/morphometric-and-volumetric-comparison-of-102-children-with-symptomatic-and-asymptomatic-chiari-malformation-type-i
#15
Siri Sahib S Khalsa, Ndi Geh, Bryn A Martin, Philip A Allen, Jennifer Strahle, Francis Loth, Desale Habtzghi, Aintzane Urbizu Serrano, Daniel McQuaide, Hugh J L Garton, Karin M Muraszko, Cormac O Maher
OBJECTIVE Chiari malformation Type I (CM-I) is typically defined on imaging by a cerebellar tonsil position ≥ 5 mm below the foramen magnum. Low cerebellar tonsil position is a frequent incidental finding on brain or cervical spine imaging, even in asymptomatic individuals. Nonspecific symptoms (e.g., headache and neck pain) are common in those with low tonsil position as well as in those with normal tonsil position, leading to uncertainty regarding appropriate management for many patients with low tonsil position and nonspecific symptoms...
January 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28853029/effect-of-high-intensity-interval-training-on-fitness-fat-mass-and-cardiometabolic-biomarkers-in-children-with-obesity-a-randomised-controlled-trial
#16
Katrin A Dias, Charlotte B Ingul, Arnt E Tjønna, Shelley E Keating, Sjaan R Gomersall, Turid Follestad, Mansoureh S Hosseini, Siri M Hollekim-Strand, Torstein B Ro, Margrete Haram, Else Marie Huuse, Peter S W Davies, Peter A Cain, Gary M Leong, Jeff S Coombes
BACKGROUND: Paediatric obesity significantly increases the risk of developing cardiometabolic diseases across the lifespan. Increasing cardiorespiratory fitness (CRF) could mitigate this risk. High-intensity interval training (HIIT) improves CRF in clinical adult populations but the evidence in paediatric obesity is inconsistent. OBJECTIVES: The objectives of this study were to determine the efficacy of a 12-week, HIIT intervention for increasing CRF and reducing adiposity in children with obesity...
March 2018: Sports Medicine
https://www.readbyqxmd.com/read/28844897/assessment-of-swallowability-and-palatability-of-oral-dosage-forms-in-children-report-from-an-m-cersi-pediatric-formulation-workshop
#17
Robert Ternik, Fang Liu, Jeremy A Bartlett, Yuet Mei Khong, David Cheng Thiam Tan, Trupti Dixit, Siri Wang, Elizabeth A Galella, Zhihui Gao, Sandra Klein
The acceptability of pediatric pharmaceutical products to patients and their caregivers can have a profound impact on the resulting therapeutic outcome. However, existing methodology and approaches used for acceptability assessments for pediatric products is fragmented, making robust and consistent product evaluations difficult. A pediatric formulation development workshop took place in Washington, DC in June 2016 through the University of Maryland's Center of Excellence in Regulatory Science and Innovation (M-CERSI)...
February 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28656175/epidemiological-and-serological-investigation-into-the-role-of-gestational-maternal-influenza-virus-infection-and-autism-spectrum-disorders
#18
Milada Mahic, Xiaoyu Che, Ezra Susser, Bruce Levin, Ted Reichborn-Kjennerud, Per Magnus, Camilla Stoltenberg, Lokendrasingh Chauhan, Thomas Briese, Michaeline Bresnahan, Pål Surén, Mady Hornig, Siri Mjaaland, W Ian Lipkin
The literature concerning gestational maternal influenza virus infection and risk of autism spectrum disorders (ASD) is inconclusive. To address this uncertainty, we obtained information from questionnaires and samples from the Autism Birth Cohort, a prospective birth cohort comprising mothers, fathers, and offspring recruited in Norway in 1999 to 2008. Through questionnaires, referrals, and linkages to the Norwegian National Patient Registry, we identified 338 mothers of children with ASD and 348 frequency-matched controls for whom plasma samples that had been collected midpregnancy and after delivery were available for influenza virus serology via luciferase immunoprecipitation and hemagglutinin inhibition assays for influenza virus strains circulating during the study period...
May 2017: MSphere
https://www.readbyqxmd.com/read/28639396/the-influence-of-parental-concern-on-the-utility-of-autism-diagnostic-instruments
#19
Karoline Alexandra Havdahl, Somer L Bishop, Pål Surén, Anne-Siri Øyen, Catherine Lord, Andrew Pickles, Stephen von Tetzchner, Synnve Schjølberg, Nina Gunnes, Mady Hornig, W Ian Lipkin, Ezra Susser, Michaeline Bresnahan, Per Magnus, Nina Stenberg, Ted Reichborn-Kjennerud, Camilla Stoltenberg
The parental report-based Autism Diagnostic Interview-Revised (ADI-R) and the clinician observation-based Autism Diagnostic Observation Schedule (ADOS) have been validated primarily in U.S. clinics specialized in autism spectrum disorder (ASD), in which most children are referred by their parents because of ASD concern. This study assessed diagnostic agreement of the ADOS-2 and ADI-R toddler algorithms in a more broadly based sample of 679 toddlers (age 35-47 months) from the Norwegian Mother and Child Cohort...
October 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28489043/underweight-stunting-and-wasting-among-children-in-kilimanjaro-region-tanzania-a-population-based-cross-sectional-study
#20
Melina Mgongo, Nikolas A S Chotta, Tamara H Hashim, Jacqueline G Uriyo, Damian J Damian, Babill Stray-Pedersen, Sia E Msuya, Margareta Wandel, Siri Vangen
This study assessed the prevalence and risk factors associated with underweight, stunting and wasting among children aged 0-24 months in six districts of Kilimanjaro region, northern Tanzania. A cross-sectional population-based study using a multistage, proportionate to size sampling was conducted from June 2010 to March 2011. A structured questionnaire was used to collect sociodemographic, economic, feeding and child information. Anthropometric data were collected by trained field workers, and the data were used to assess child nutritional status...
May 10, 2017: International Journal of Environmental Research and Public Health
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