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hemifacial spasm,botulinum toxin

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https://www.readbyqxmd.com/read/29116410/botulinum-toxin-therapy-in-patients-with-oral-anticoagulation-is-it-safe
#1
Christoph Schrader, Markus Ebke, Fereshte Adib Saberi, Dirk Dressler
When used therapeutically, botulinum toxin (BT) has to be injected into its target tissues. All manufacturers warn not to do so in patients with oral anticoagulation to avoid haematoma. We wanted to study the haematoma frequency (HF) in patients with anticoagulation receiving BT therapy. 32 patients (16 females, 16 males, age 69.3 ± 10.0 years) with blepharospasm (n = 6), hemifacial spasm (n = 8), post-stroke spasticity (n = 16), and cervical dystonia (n = 2) received BT therapy (needle size 27G, post-injection tissue compression) whilst on anticoagulation (anticoagulation group, AG)...
November 7, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29026661/tenth-case-of-bilateral-hemifacial-spasm-treated-by-microvascular-decompression-review-of-the-pathophysiology
#2
REVIEW
Warley Carvalho da Silva Martins, Lucas Alverne Freitas de Albuquerque, Gervásio Teles Cardoso de Carvalho, Jules Carlos Dourado, Marcos Dellaretti, Atos Alves de Sousa
BACKGROUND: Bilateral hemifacial spasm (BHFS) is a rare neurological syndrome whose diagnosis depends on excluding other facial dyskinesias. We present a case of BHFS along with a literature review. METHODS: A 64-year-old white, hypertense male reported involuntary left hemiface contractions in 2001 (aged 50). In 2007, right hemifacial symptoms appeared, without spasm remission during sleep. Botulinum toxin type A application produced partial temporary improvement...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28965229/treatment-of-blepharospasm-hemifacial-spasm
#3
REVIEW
Kemar E Green, David Rastall, Eric Eggenberger
The treatment of both hemifacial spasm (HFS) and blepharospasm (BEB) requires making the appropriate clinical diagnosis. Advance imaging and electrophysiologic studies are useful; however, one's clinical suspicion is paramount. The purpose of this review is to summarize current and emerging therapies for both entities. Botulinum toxin (BTX) remains the first-line therapy to treat both conditions. If chemodenervation has failed, surgery may be considered. Due to the risks associated with surgery, the benefits of this option must be carefully weighed...
September 30, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28884242/a-comparative-crossover-study-on-the-treatment-of-hemifacial-spasm-and-blepharospasm-preseptal-and-pretarsal-botulinum-toxin-injection-techniques
#4
Praween Lolekha, Arthita Choolam, Kongkiat Kulkantrakorn
Hemifacial spasm (HFS) and benign essential blepharospasm (BEB) are chronic and disabling abnormal craniofacial movements that produce involuntary eyelid twitching and closure. The efficacy and safety of botulinum toxin type A (BoNT-A) injections have been accepted and widely used for the treatment of HFS and BEB. However, different injection sites may influence the effectiveness, doses, and side effects. The aim of this study is to compare the efficacy, patient satisfaction, and complications of low-dose BoNT-A injections between injection at the preseptal (PS) and the pretarsal (PT) portion of the orbicularis oculi muscle...
November 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28734794/botulinum-toxin-a-is-effective-to-treat-tension-type-headache-caused-by-hemifacial-spasm
#5
Atsushi Mizuma, Eiichiro Nagata, Takashi Yasuda, Maiko Kouchi, Taira Nakayama, Kazunari Honma, Kentaro Tokuoka, Yasuhisa Kitagawa, Shigeru Nogawa, Shunya Takizawa
OBJECTIVE: We examined the relationship between hemifacial spasm (HFS; a form of cranio-cervical dystonia) and chronic primary headache, including tension-type headache (TTH). We also examined whether botulinum toxin A (BoNT/A) therapy for HFS ameliorates concomitant TTH. METHODS: Fifty-one HFS patients receiving BoNT/A therapy were recruited. Patients' characteristics (including age, gender, chronic headache history, exercise habits, stiff neck, cervical spondylolysis history), stress factors, worsening/new onset of headache associated with HFS, and dose of BoNT/A were examined...
October 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28627956/evaluating-the-effects-of-botulinum-toxin-a-on-tear-metrics-in-patients-with-hemifacial-spasm
#6
Yasmin Poustchi Mali, Robert L Schultze, Edward J Wladis
Hemifacial spasm has been previously shown to result in dry eye and ocular surface diseases. This study was performed to assess the impact of chemodenervation with botulinum toxin on clinically-relevant metrics of tears. Tear osmolarity and lipid layer thickness were measured in patients with hemifacial spasm after they achieved relief from hemifacial spasm via botulinum toxin injections. Twelve eyes of 6 patients with hemifacial spasm (2 men and 4 women; mean age 55.5 years) were assessed in accordance with the Declaration of Helsinki and IRB approval...
June 19, 2017: Orbit
https://www.readbyqxmd.com/read/28566174/role-of-the-other-babinski-sign-in-hyperkinetic-facial-disorders
#7
Sara Varanda, Sofia Rocha, Margarida Rodrigues, Álvaro Machado, Gisela Carneiro
BACKGROUND: The "other Babinski sign" consists in the co-contraction of the orbicularis and frontalis muscles, causing an eyebrow elevation during ipsilateral eye closure. It cannot be voluntarily reproduced. AIMS OF THE STUDY: To determine the utility of this sign in the differential diagnosis of hyperkinetic facial disorders. METHODS: The presence of the sign was assessed in consecutive patients with blepharospasm, primary hemifacial spasm or post-paralytic facial syndrome treated in a botulinum toxin outpatient clinic...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28540017/cluster-headache-associated-with-secondary-unilateral-blepharospasm-a-case-report-and-review-of-the-literature
#8
Abbas Bagheri, Minoo Mohammadi, Ghader Harooni, Keyvan Khosravifard, Mohadeseh Feizi, Shahin Yazdani
PURPOSE: Cluster headache is one of the most serious types of headache that is accompanied by autonomic parasympathetic symptoms. Its association with hemifacial spasm in the same side had been rarely reported. The aim of this report is describing a case with this association and treatment strategies. CASE REPORT: Here we report a 37-year-old female with cluster headache associated with secondary unilateral blepharospasm that was successfully treated with combination therapy including botulinum toxin injection...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28507604/health-related-quality-of-life-outcomes-from-botulinum-toxin-treatment-in-hemifacial-spasm
#9
Daniel Weiss, Justine Sturm, Leonhard Hieber, Axel Börtlein, Ingo Mayr, Matthias Appy, Benedicta Kühnler, Joachim Buchthal, Christian Dippon, Guy Arnold, Tobias Wächter
BACKGROUND: Although botulinum neurotoxin (BoNT) injections may alleviate involuntary muscle contractions in hemifacial spasm substantially, it is less clear whether the motor effect would translate into improvements of health-related quality of life (HR-QoL). METHODS: In this open-label clinical observational study, we characterized outcomes on HR-QoL in terms of the EuroQol (EQ-5D-5L) from BoNT in a prospective cohort of patients with hemifacial spasm (n = 73)...
April 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28465830/economics-of-botulinum-toxin-therapy-influence-of-the-abobotulinumtoxina-package-size-on-the-costs-of-botulinum-toxin-therapy
#10
Dirk Dressler, Fereshte Adib Saberi
BACKGROUND: AbobotulinumtoxinA (Dysport®) was distributed for many years in vials containing 500MU (D500). Recently a new 300MU vial (D300) was additionally introduced (introduction). We wanted to explore whether more differentiated package sizes allow for more economic use of Dysport® in a large neurological botulinum toxin (BT) outpatient clinic. METHODS: The study followed a retrospective chart review design based on our digital BT therapy data bank. All patients receiving Dysport® exclusively in a constant dose during the observation period (introduction ± 7 months) were included...
2017: Journal of Clinical Movement Disorders
https://www.readbyqxmd.com/read/28437820/-therapy-of-hemifacial-spasm-with-botulinum-toxin
#11
Wolfgang H Jost, Rainer Laskawi, Anja Palmowski-Wolfe, Peter P Urban
Hemifacial spasm (HFS) is a frequent disorder characterized by involuntary contractions of those muscles innervated by the facialis nerve on one side of the face. The symptoms can appear as tonic or clonic, intermittent or permanent. Diagnosis is based purely on clinical observation. Differential diagnosis should rely on cranial MRI, which can demonstrate a pathological contact between the nerves and vessels and exclude alternative causation. Often, the symptoms are not marked so that therapy may not be necessary...
April 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28226076/treatment-of-hemifacial-spasm-with-botulinum-toxin-type-a-effective-long-lasting-and-well-tolerated
#12
Jean Pierre Mette Batisti, Alais Daiane Fadini Kleinfelder, Natália Bassalobre Galli, Adriana Moro, Renato Puppi Munhoz, Hélio Afonso Ghizoni Teive
Objective: To evaluate the long-term effect of botulinum toxin type A (BTX-A) in the treatment of HFS. Methods: A retrospective analysis of patients treated at the Movement Disorders Outpatient Clinic in the Neurology Service, Hospital de Clínicas, Federal University of Paraná, Curitiba, from 2009 to 2013 was carried out. A total of 550 BTX-A injections were administered to 100 HFS patients. Results: Mean duration of improvement following each injection session was 3...
February 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28223858/the-therapeutic-usage-of-botulinum-toxin-botox-in-non-cosmetic-head-and-neck-conditions-an-evidence-based-review
#13
REVIEW
Kamran Habib Awan
Botulinum toxin (Botox) is an exotoxin produced from Clostridium botulinum. It blocks the release of acetylcholine from the cholinergic nerve end plates resulting in inactivity of the muscles or glands innervated. The efficacy of Botox in facial aesthetics is well established; however, recent literature has highlighted its utilization in multiple non-cosmetic medical and surgical conditions. The present article reviews the current evidence pertaining to Botox use in the non-cosmetic head and neck conditions...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28186450/an-investigation-into-quality-of-life-improvement-in-patients-undergoing-microvascular-decompression-for-hemifacial-spasm
#14
Jesse D Lawrence, Andrew M Frederickson, Yue-Fang Chang, Patricia M Weiss, Peter C Gerszten, Raymond F Sekula
OBJECTIVE Hemifacial spasm (HFS) is a movement disorder characterized by involuntary spasms of the facial muscles, and it can negatively impact quality of life (QOL). This retrospective study and systematic review with meta-analysis was conducted to investigate the QOL in patients with HFS following intervention with microvascular decompression (MVD) and botulinum toxin (BT). METHODS In the retrospective analysis, a QOL questionnaire was administered to all patients undergoing MVD performed by a single surgeon...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28114700/-botulinum-toxin-new-developments-in-ophthalmology
#15
B Wabbels
Botulinum toxin is recognised as the gold standard for the treatment of essential blepharospasm and hemifacial spasm, which is similar in effect in synkinesis after facial nerve palsy. The injection intervals can be adjusted according to the patients' needs and be shortened for up to six weeks in cases of eyelid cramping. Newer indications for the use of botulinum toxin in ophthalmology include eyelid retraction in Graves' disease, induction of protective ptosis and treatment of crocodile tears syndrome after facial nerve palsy...
January 23, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28088801/natural-history-of-untreated-hemifacial-spasm-a-study-of-104-consecutive-patients-over-5-years
#16
Jeong-A Lee, Kyung-Hee Kim, Kwan Park
BACKGROUND: The natural history without treatment of a large series of hemifacial spasm (HFS) patients has not been well-documented. OBJECTIVE: The purpose of this study was to characterize the natural history and clinical outcome in patients with HFS. METHODS: The initial visits of all 2,155 patients and the diagnosis of HFS took place between 2001 and 2010. In 1,775 of the patients, compressing vessels were identified on magnetic resonance imaging...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28050326/use-of-botulinum-neurotoxin-in-ophthalmology
#17
REVIEW
Emel Başar, Ceyhun Arıcı
Botulinum neurotoxin (BoNT) is the first biological toxin used in the treatment of ophthalmic diseases and to decrease skin wrinkles as an aesthetic agent. When used appropriately, it weakens the force of muscular contraction and/or inhibits glandular secretion. The most common areas for botulinum toxin treatment are the upper face, including the glabella, forehead, brows, and lateral canthal lines, or crow's feet. By relaxing the muscles causing wrinkles, non-permanent results may be achieved with its use...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27906546/persistent-hemifacial-spasm-after-microvascular-decompression-a-risk-assessment-model
#18
Aalap Shah, Michael Horowitz
OBJECTIVE: Microvascular decompression (MVD) for hemifacial spasm (HFS) provides resolution of disabling symptoms such as eyelid twitching and muscle contractions of the entire hemiface. The primary aim of this study was to evaluate the predictive value of patient demographics and spasm characteristics on long-term outcomes, with or without intraoperative lateral spread response (LSR) as an additional variable in a risk assessment model. METHODS: A retrospective study was undertaken to evaluate the associations of pre-operative patient characteristics, as well as intraoperative LSR and need for a staged procedure on the presence of persistent or recurrent HFS at the time of hospital discharge and at follow-up...
December 1, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27802860/hemifacial-spasm-in-a-patient-with-basilar-artery-dolichoectasia-caused-by-uncontrolled-hypertension
#19
Gordon S Crabtree, David Gish, David Goldberg
A 47-year-old male presented with a 2-year history of hemifacial spasm. Magnetic resonance imaging performed showed his tortuous basilar artery with nerve compression, and the patient was treated conservatively with botulinum toxin injections with complete resolution of symptoms. This rare disease was caused by his long history of hypertension, which led to his major basilar artery dolichoectasia.
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27761290/a-rare-cause-of-hemifacial-spasm-papillary-oncocytic-cystadenoma
#20
Ozan Erol, Erdinç Aydın
BACKGROUND: Hemifacial spasm is a sudden, involuntary and synchronous spasm of the facial muscles. The most frequent cause of this condition is compression of the facial nerves due to vascular pathologies. The most commonly used method of treatment is Botulinum toxin injection. However, the gold standard treatment is surgical treatment. CASE REPORT: A 64-year-old male patient with hemifacial spasms, which had occurred due to a rare parotid mass that had been surgically treated, is presented in this case...
September 2016: Balkan Medical Journal
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