keyword
https://read.qxmd.com/read/38481730/prognostic-impact-of-the-bone-marrow-tumor-microenvironment-hla-i-and-hla-ib-expression-in-mds-and-cmml-progression-to-saml
#21
JOURNAL ARTICLE
Marcus Bauer, Nadja Jäkel, Andreas Wilfer, Anja Haak, Markus Eszlinger, Katalin Kelemen, Monika Haemmerle, Haifa Kathrin Al-Ali, Barbara Seliger, Claudia Wickenhauser
Genetic aberrations and immune escape are fundamental in MDS and CMML initiation and progression to sAML. Therefore, quantitative and spatial immune cell organization, expression of immune checkpoints (ICP), classical human leukocyte antigen class I (HLA-I) and the non-classical HLA-Ib antigens were analyzed in 274 neoplastic and 50 non-neoplastic bone marrow (BM) biopsies using conventional and multiplex immunohistochemistry and correlated to publicly available dataset. Higher numbers of tissue infiltrating lymphocytes (TILs) were found in MDS/CMML (8...
2024: Oncoimmunology
https://read.qxmd.com/read/38480731/hla-class-ii-restricted-tcr-targeting-human-papillomavirus-type-18-e7-induces-solid-tumor-remission-in-mice
#22
JOURNAL ARTICLE
Jianting Long, Xihe Chen, Mian He, Shudan Ou, Yunhe Zhao, Qingjia Yan, Minjun Ma, Jingyu Chen, Xuping Qin, Xiangjun Zhou, Junjun Chu, Yanyan Han
T cell receptor (TCR)-engineered T cell therapy is a promising potential treatment for solid tumors, with preliminary efficacy demonstrated in clinical trials. However, obtaining clinically effective TCR molecules remains a major challenge. We have developed a strategy for cloning tumor-specific TCRs from long-term surviving patients who have responded to immunotherapy. Here, we report the identification of a TCR (10F04), which is human leukocyte antigen (HLA)-DRA/DRB1*09:01 restricted and human papillomavirus type 18 (HPV18) E784-98 specific, from a multiple antigens stimulating cellular therapy (MASCT) benefited metastatic cervical cancer patient...
March 13, 2024: Nature Communications
https://read.qxmd.com/read/38480275/upregulation-of-hla-ii-related-to-lag-3-cd4-t-cell-infiltration-is-associated-with-patient-outcome-in-human-glioblastoma
#23
JOURNAL ARTICLE
Wenli Guo, Daijun Peng, Yuee Liao, Lei Lou, Moran Guo, Chen Li, Wangyang Yu, Xiaoxi Tian, Guohui Wang, Ping Lv, Jing Zuo, Haitao Shen, Yuehong Li
Glioblastoma (GBM) is the most common malignant diffuse glioma of the brain. Although immunotherapy with immune checkpoint inhibitors (ICIs), such as programmed cell death protein (PD)-1/PD ligand-1 inhibitors, has revolutionized the treatment of several cancers, the clinical benefit in GBM patients has been limited. Lymphocyte-activation gene 3 (LAG-3) binding to human leukocyte antigen-II (HLA-II) plays an essential role in triggering CD4+ T cell exhaustion and could interfere with the efficiency of anti-PD-1 treatment; however, the value of LAG-3-HLA-II interactions in ICI immunotherapy for GBM patients has not yet been analyzed...
March 13, 2024: Cancer Science
https://read.qxmd.com/read/38476237/poor-prognostic-factors-of-pharmacokinetic-origin-predict-outcomes-in-inflammatory-bowel-disease-patients-treated-with-anti-tumor-necrosis-factor-%C3%AE
#24
JOURNAL ARTICLE
Elizabeth A Spencer, Marla C Dubinsky, Michael A Kamm, Maria Chaparro, Paolo Gionchetti, Fernando Rizzello, Javier P Gisbert, Emily K Wright, Julien D Schulberg, Amy L Hamilton, Dermot P B McGovern, Thierry Dervieux
INTRODUCTION: We evaluated baseline Clearance of anti-tumor necrosis factors and human leukocyte antigen variant (HLA DQA1*05) in combination as poor prognostic factors (PPF) of pharmacokinetic (PK) origin impacting immune response (formation of antidrug antibodies) and disease control of inflammatory bowel disease (IBD) patients treated with infliximab or adalimumab. METHODS: Baseline Clearance was estimated in IBD patients before starting treatment using weight and serum albumin concentrations...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38473398/dual-checkpoint-aptamer-immunotherapy-unveiling-tailored-cancer-treatment-targeting-ctla-4-and-nkg2a
#25
JOURNAL ARTICLE
Mohamad Ammar Ayass, Trivendra Tripathi, Natalya Griko, Tutku Okyay, Ramya Ramankutty Nair, Jin Zhang, Kevin Zhu, Kristen Melendez, Victor Pashkov, Lina Abi-Mosleh
Recent strides in immunotherapy have illuminated the crucial role of CTLA-4 and PD-1/PD-L1 pathways in contemporary oncology, presenting both promises and challenges in response rates and adverse effects. This study employs a computational biology tool (in silico approach) to craft aptamers capable of binding to dual receptors, namely, inhibitory CTLA4 and NKG2A, thereby unleashing both T and NK cells and enhancing CD8+ T and NK cell functions for tumor cell lysis. Computational analysis highlighted AYA22T-R2-13 with HADDOCK scores of -78...
March 4, 2024: Cancers
https://read.qxmd.com/read/38468286/seven-chain-adaptive-immune-receptor-repertoire-analysis-in-rheumatoid-arthritis-reveals-novel-features-associated-with-disease-and-clinically-relevant-phenotypes
#26
JOURNAL ARTICLE
Adrià Aterido, María López-Lasanta, Francisco Blanco, Antonio Juan-Mas, María Luz García-Vivar, Alba Erra, Carolina Pérez-García, Simón Ángel Sánchez-Fernández, Raimon Sanmartí, Antonio Fernández-Nebro, Mercedes Alperi-López, Jesús Tornero, Ana María Ortiz, Carlos Marras Fernández-Cid, Núria Palau, Wenjing Pan, Miranda Byrne-Steele, Dmytro Starenki, Daniel Weber, Ivan Rodriguez-Nunez, Jian Han, Richard M Myers, Sara Marsal, Antonio Julià
BACKGROUND: In rheumatoid arthritis (RA), the activation of T and B cell clones specific for self-antigens leads to the chronic inflammation of the synovium. Here, we perform an in-depth quantitative analysis of the seven chains that comprise the adaptive immune receptor repertoire (AIRR) in RA. RESULTS: In comparison to controls, we show that RA patients have multiple and strong differences in the B cell receptor repertoire including reduced diversity as well as altered isotype, chain, and segment frequencies...
March 11, 2024: Genome Biology
https://read.qxmd.com/read/38462571/mutational-immune-microenvironment-and-clinicopathological-profiles-of-diffuse-large-b-cell-lymphoma-and-follicular-lymphoma-with-bcl6-rearrangement
#27
JOURNAL ARTICLE
Joaquim Carreras, Haruka Ikoma, Yara Yukie Kikuti, Masashi Miyaoka, Shinichiro Hiraiwa, Sakura Tomita, Yusuke Kondo, Atsushi Ito, Shunsuke Nagase, Hisanobu Miura, Hiroshi Kawada, Giovanna Roncador, Elias Campo, Rifat Hamoudi, Naoya Nakamura
BCL6-rearrangement (BCL6-R) is associated with a favorable prognosis of follicular lymphoma (FL), but the mechanism is unknown. We analyzed the clinicopathological, immune microenvironment (immune checkpoint, immuno-oncology markers), and mutational profiles of 10 BCL6-R-positive FL, and 19 BCL6-R-positive diffuse large B-cell lymphoma (DLBCL) cases (both BCL2-R and MYC-R negative). A custom-made panel included 168 genes related to aggressive B-cell lymphomas and FL. FL cases were nodal, histological grade 3A in 70%, low Ki67; and had a favorable overall and progression-free survival...
March 11, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38462357/-challenges-and-solutions-in-current-human-leukocyte-antigen-confirmatory-typing-of-hematopoietic-stem-cell-transplantation
#28
JOURNAL ARTICLE
X J Bao, X N Yuan, J He
The impact of human leukocyte antigen (HLA) on hematopoietic stem cell transplantation (HSCT) necessitates high precision in HLA genotyping. Confirmatory typing for patients and their related or unrelated donors before HSCT is critical. This study seeks to standardize HLA confirmatory typing in laboratories by examining the current state of HLA genotyping in the country, building upon the National Standards and Industrial Standards for HLA, and highlighting the significance of confirmatory typing for patients and potential donors prior to HSCT...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38458635/neoadjuvant-chemoradiotherapy-combined-with-sequential-perioperative-toripalimab-in-locally-advanced-esophageal-squamous-cell-cancer
#29
JOURNAL ARTICLE
Xin Xu, Zhiyong Sun, Qiang Liu, Yao Zhang, Lei Shen, Chenpeng Zhang, Haiping Lin, Bin Hu, Ling Rong, Haiyan Chen, Xiaohang Wang, Xiaojing Zhao, Yong-Rui Bai, Qing Ye, Xiumei Ma
BACKGROUND: Programmed death 1 (PD-1) inhibitor demonstrated durable antitumor activity in advanced esophageal squamous cell carcinoma (ESCC), but the clinical benefit of perioperative immunotherapy in ESCC remains unclear. This study evaluated the efficacy and safety of neoadjuvant chemoradiotherapy (nCRT) combined with the PD-1 inhibitor toripalimab in patients with resectable ESCC. METHODS: From July 2020 to July 2022, 21 patients with histopathologically confirmed thoracic ESCC and clinical staged as cT1-4aN1-2M0/cT3-4aN0M0 were enrolled...
March 7, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38455061/tumor-beta2-microglobulin-and-hla-a-expression-is-increased-by-immunotherapy-and-can-predict-response-to-cit-in-association-with-other-biomarkers
#30
JOURNAL ARTICLE
Bernhard Reis, Jan Attig, Sebastian Dziadek, Nico Graefe, Astrid Heller, Natascha Rieder, Bruno Gomes
BACKGROUND: Downregulation of MHC class I expression and/or defects in the antigen presentation pathways are commonly reported in human cancers. Numerous studies previously have explored extensively the molecular mechanisms that underlie HLA-class I and Beta2-Microglobulin (B2M) downregulation. However, the techniques presently available to detect expression of MHC class I proteins lack the robustness, specificity and sensitivity needed for systematic integration and analysis in clinical trials...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38452872/umbilical-cord-blood-transplantation-for-fanconi-anemia-with-a-special-focus-on-late-complications-a-study-on-behalf-of-eurocord-and-saawp-ebmt
#31
JOURNAL ARTICLE
Hanadi Rafii, Fernanda Volt, Marc Bierings, Jean-Hugues Dalle, Mouhab Ayas, Rawad Rihani, Maura Faraci, Giuseppina de Simone, Henrik Sengeloev, Jakob Passweg, Marina Cavazzana, Regis Costello, Johan Maertens, Alessandra Biffi, Jan-Erik Johansson, Juan Montoro, Gabrielle Roth Guepin, Miguel Angel Diaz, Anne Sirvent, Chantal Kenzey, Monica M Rivera Franco, Barbara Cappelli, Graziana Maria Scigliuolo, Vanderson Rocha, Annalisa Ruggeri, Antonio Risitano, Regis Peffault De Latour, Eliane Gluckman
BACKGROUND: Hematopoietic cell transplant (HCT) remains the only available curative treatment for Fanconi Anemia (FA), with particularly favorable outcomes reported after matched sibling donor (MSD) transplant. OBJECTIVES: To describe outcomes, with a special focus on late complications, in FA patients who underwent umbilical cord blood transplantation (UCBT). STUDY DESIGN: Retrospective analysis of allogeneic UCBT for FA performed between 1988 and 2021 in European Society for Blood and Marrow Transplantation (EBMT) affiliated centers...
March 5, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38443603/anti-tumor-necrosis-factor-atnf-weaning-strategy-in-juvenile-idiopathic-arthritis-jia-does-duration-matter
#32
JOURNAL ARTICLE
Kai Liang Teh, Lena Das, Yun Xin Book, Sook Fun Hoh, Xiaocong Gao, Thaschawee Arkachaisri
BACKGROUND: To compare outcomes of a short and long weaning strategy of anti-tumor necrosis factor (aTNF) in our prospective juvenile idiopathic arthritis (JIA) cohort. RESEARCH DESIGN AND METHODS: JIA patients on subcutaneous adalimumab with at least 6 months of follow-up were recruited (May 2010-Jan 2022). Once clinical remission on medication (CRM) was achieved, adalimumab was weaned according to two protocols-short (every 4-weekly for 6 months and stopped) and long (extending dosing interval by 2 weeks for three cycles until 12-weekly intervals and thereafter stopped) protocols...
March 5, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38443448/development-of-nk-cell-based-cancer-immunotherapies-through-receptor-engineering
#33
REVIEW
Audrey Page, Nicolas Chuvin, Jenny Valladeau-Guilemond, Stéphane Depil
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field of cancer treatment. Early clinical trials have shown promising outcomes, alongside satisfactory product efficacy and safety. Recent developments have greatly increased the therapeutic potential of NK cells by endowing them with enhanced recognition and cytotoxic capacities. This review focuses on surface receptor engineering in NK cell therapy and discusses its impact, challenges, and future directions.Most approaches are based on engineering with chimeric antigen receptors to allow NK cells to target specific tumor antigens independent of human leukocyte antigen restriction...
March 5, 2024: Cellular & Molecular Immunology
https://read.qxmd.com/read/38434980/causal-relationship-between-immune-cells-and-gynecological-cancers-through-bidirectional-and-multivariable-mendelian-randomization-analyses
#34
JOURNAL ARTICLE
Yangyang Zhang, Yangyuxiao Lu, Xuanyu Wang, Keren He, Mengqi Fang, Jiabao Xu, Ye Xu, Fangfang Tao, Ping Lü
Background: Evidence suggests potential associations between gynecological malignancies and various immune cell chemicals and systems. However, establishing a causal relationship remains uncertain. Methods: This work employed Wald ratio for one single-nucleotide polymorphism (SNP) or the inverse-variance weighted method (IVW) for multiple SNPs to conduct bidirectional two-sample Mendelian randomization (MR) analysis by utilizing genome-wide association study (GWAS) data. We employed supplementary methods, including MR-Egger and weighted median methods, to detect and correct for the influence of horizontal pleiotropy...
2024: Journal of Cancer
https://read.qxmd.com/read/38434301/decreased-circulating-myeloid-derived-suppressor-cell-count-at-the-engraftment-is-one-of-the-risk-factors-for-multiple-myeloma-relapse-after-autologous-hematopoietic-stem-cell-transplantation
#35
JOURNAL ARTICLE
Tamara Tyrinova, Egor Batorov, Tatyana Aristova, Galina Ushakova, Svetlana Sizikova, Vera Denisova, Elena Chernykh
Recent studies demonstrated that myeloid-derived suppressor cells (MDSCs) are involved in the pathogenesis and progression of multiple myeloma (MM). Nevertheless, data on the quantitative and functional changes in MDSCs during standard MM treatment remain poorly understood. Here, we determined that monocytic MDSCs (M-MDSC; CD14+ HLA-DRlow/- ) and granulocytic MDSCs (PMN-MDSC; Lin- HLA-DR- CD33+ CD66b+ ) in MM patients in remission following induction therapy (IT) were significantly increased, while early MDSCs (E-MDSCs; Lin- HLA-DR- CD33+ CD66b- ) were decreased compared to the donor group...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38432114/genomic-profiles-and-their-relationships-with-clinical-characteristics-and-immune-features-in-cervical-cancer
#36
JOURNAL ARTICLE
Zinan Lu, Peiwen Fan, Wen Huo, Yaning Feng, Ruozheng Wang
OBJECTIVE: This study aimed to investigate the genomic alteration profiles of cervical cancer patients, examine the correlation between mutation patterns and clinical and immune attributes, and discover novel targets for treatment of individuals with cervical cancer. METHODS: We performed targeted next-generation sequencing of tumor tissues and blood samples obtained from 45 cervical cancer patients to analyze somatic alterations, mutation patterns, and HLA alleles comprehensively...
March 2, 2024: Translational Oncology
https://read.qxmd.com/read/38427583/expanding-the-repertoire-reveals-recurrent-cryptic-and-hematopoietic-hla-class-i-minor-histocompatibility-antigens
#37
JOURNAL ARTICLE
Kyra J Fuchs, Marian van de Meent, Maria W Honders, Indu Khatri, Michel G D Kester, Eva A S Koster, Georgia Koutsoumpli, Arnoud H de Ru, Cornelis A M Van Bergen, Peter A van Veelen, Peter A C 't Hoen, Peter van Balen, Erik B van den Akker, Hendrik Veelken, Constantijn Jm Jm Halkes, J H Frederik Falkenburg, Marieke Griffioen
Allogeneic stem cell transplantation (alloSCT) is a curative treatment for hematological malignancies. After HLA-matched alloSCT, anti-tumor immunity is caused by donor T cells recognizing polymorphic peptides, designated minor histocompatibility antigens (MiHAs), that are presented by HLA on malignant patient cells. However, T cells often target MiHAs on healthy non-hematopoietic tissues of patients, thereby inducing side effects known as Graft-versus-Host Disease. Here, we aimed to identify the dominant repertoire of HLA-I-restricted MiHAs to enable strategies to predict, monitor or modulate immune responses after alloSCT...
March 1, 2024: Blood
https://read.qxmd.com/read/38427106/comprehensive-analysis-of-dna-methylation-gene-expression-profiles-in-geo-dataset-reveals-biomarkers-related-to-malignant-transformation-of-sinonasal-inverted-papilloma
#38
JOURNAL ARTICLE
Li Mu, Shun Hu, Guoping Li, Ping Wu, Ke Zheng, Sheng Zhang
BACKGROUND: DNA methylation may be involved in the regulation of malignant transformation from sinonasal inverted papilloma (SNIP) to squamous cell carcinoma (SCC). The study of gene methylation changes and screening of differentially methylated loci (DMLs) are helpful to predict the possible key genes in the malignant transformation of SNIP-SCC. MATERIALS AND METHODS: Microarray dataset GSE125399 was downloaded from the Gene Expression Omnibus (GEO) database and differentially methylated loci (DMLs) were analyzed using R language (Limma package)...
March 1, 2024: Discover. Oncology
https://read.qxmd.com/read/38425404/comprehensive-analysis-of-the-protein-phosphatase-2a-regulatory-subunit-b56%C3%AE%C2%B5-in-pan-cancer-and-its-role-and-mechanism-in-hepatocellular-carcinoma
#39
JOURNAL ARTICLE
Hong-Mei Wu, Yuan-Yuan Huang, Yu-Qiu Xu, Wei-Lai Xiang, Chang Yang, Ru-Yuan Liu, Di Li, Xue-Feng Guo, Zheng-Bao Zhang, Chun-Hua Bei, Sheng-Kui Tan, Xiao-Nian Zhu
BACKGROUND: B56ε is a regulatory subunit of the serine/threonine protein phosphatase 2A, which is abnormally expressed in tumors and regulates various tumor cell functions. At present, the application of B56ε in pan-cancer lacks a comprehensive analysis, and its role and mechanism in hepatocellular carcinoma (HCC) are still unclear. AIM: To analyze B56ε in pan-cancer, and explore its role and mechanism in HCC. METHODS: The Cancer Genome Atlas, Genotype-Tissue Expression, Gene Expression Profiling Interactive Analysis, and Tumor Immune Estimation Resource databases were used to analyze B56ε expression, prognostic mutations, somatic copy number alterations, and tumor immune characteristics in 33 tumors...
February 15, 2024: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38420797/polymorphism-of-hla-and-susceptibility-of-breast-cancer
#40
REVIEW
Sara Aboulaghras, Asaad Khalid, Hafiz A Makeen, Hassan A Alhazmi, Mohammed Albratty, Syam Mohan, Bey Hing Goh, Chien Ing Yeo, Yee Seng Tan, Abdelhakim Bouyahya
Breast cancer (BC) is the second most common malignancy in the world. Numerous studies have demonstrated the association between human leukocyte antigen (HLA) and cancer. The occurrence and development of BC are closely linked to genetic factors. Human leukocyte antigens G and E (HLA-G and HLA-E) are non-classical major histocompatibility complex (MHC) class I molecules. These molecules play an important role in immune surveillance by inhibiting the cytotoxic and natural killer T cells responsible for immune escape...
February 5, 2024: Frontiers in Bioscience (Landmark Edition)
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