Gregory P Williams, Tanner Michaelis, João Rodrigues Lima-Junior, April Frazier, Ngan K Tran, Elizabeth J Phillips, Simon A Mallal, Irene Litvan, Jennifer G Goldman, Roy N Alcalay, John Sidney, David Sulzer, Alessandro Sette, Cecilia S Lindestam Arlehamn
Parkinson's disease (PD) is associated with autoimmune T cells that recognize the protein alpha-synuclein in a subset of individuals. Multiple neuroantigens are targets of autoinflammatory T cells in classical central nervous system autoimmune diseases such as multiple sclerosis (MS). Here, we explored whether additional autoantigenic targets of T cells in PD. We generated 15-mer peptide pools spanning several PD-related proteins implicated in PD pathology, including GBA, SOD1, PINK1, parkin, OGDH, and LRRK2...
February 12, 2024: bioRxiv