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Claudia Orellana-Tavra, Salame Haddad, Ross J Marshall, Isabel Abanades Lazaro, Gerard Boix, Inhar Imaz, Daniel Maspoch, Ross S Forgan, David Fairen-Jimenez
A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an effi-cient drug delivery system...
September 19, 2017: ACS Applied Materials & Interfaces
Shilpi Kushwaha, Arunava Maity, Monalisa Gangopadhyay, Sapna Ravindranathan, Pattuparambil R Rajamohanan, Amitava Das
A unique fluorescence resonance energy transfer (FRET) process is found to be operational in a unilamellar lipid self-assembly in the aqueous phase. A newly synthesized naphthyl based long chain lipid derivative [N-(naphthalene-1-ylmethyl)tetradecane-1-ammonium chloride, 14NA+] forms various self-assembled architectures in the aqueous phase. Controlled changes in lipid concentration lead to a transition of the self-assemblies from micelles to vesicles to rods. In the presence of cucurbit[7]uril (CB7), 14NA+ forms a host-guest [2]pseudorotaxane complex (CB7∋14NA+) and secondary interactions lead to the formation of a lipid bilayer with hydrophobic pockets situated in between the layers...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Bin-Xia Xue, Tong-Yu Li, Chun-Ying Li, Li Wei, Xiao-He Hou
Winter cities have severe shortages of water resources. The effective classification and recycling of urban water resources that are available here are therefore significant for the sustainable utilization of water in winter cities, and snow is a potential water resource. In this research, the water quality of the snow and the pollutant composition in the vehicle roads of a typical residential community of Harbin are analyzed. It is concluded that there is a large amount of suspended substances, including chemical oxygen demand (COD), salt, ammonia, and oil in this snow...
September 17, 2017: Environmental Science and Pollution Research International
Priyanka Agarwal, Laxmi Singh, Madhu Anand, Ajay Taneja
Polycyclic aromatic hydrocarbons are known to disturb the antioxidant defense system, which may indirectly contribute to induction of early pregnancy in women. Therefore, the present investigation was designed to offer preliminary information about exposure to PAHs by estimating their placental levels and its association with oxidative stress as well as with preterm birth. Placenta tissue samples were drawn after delivery from 84 healthy pregnant women, recruited at a local nursing home of Agra, India, and levels of PAHs were quantified by gas chromatograph equipped with flame ionization detector...
September 15, 2017: Archives of Environmental Contamination and Toxicology
Bo Jiang, Feng Liu, Jia-Yin Wang, Peng Zhou, Guigen Li, Wen-Juan Hao, Shu-Jiang Tu
Metal-free [2 + 2] cycloaddition and S-centered radical-induced 1,4-addition cascades have been achieved by treating benzene-linked allene-ynes with aryldiazonium tetrafluoroborates and DABCO-bis(sulfur dioxide) in a one-pot operation; the reaction provides a greener and practical access to functionalized cyclobuta[a]naphthalen-4-ols of valuable applications. More than 50 examples were examined to achieve up to excellent diastereoselectivity and yields. The reaction pathway is proposed to proceed through the sequence of [2 + 2] cycloaddition, insertion of SO2, 1,4-addition, diazotization and tautomerization...
September 14, 2017: Angewandte Chemie
Doli Srivani, Anubha Agarwal, Sidhanath V Bhosale, Avinash L Puyad, Wanchun Xiang, Richard A Evans, Akhil Gupta, Sheshanath V Bhosale
Herein we present the design, synthesis and characterization of two novel, naphthalene diimide (NDI) core-based non-fullerene acceptors, N5 and N6, comprising respectively 2-methoxyethyl-2-cyanoacetate and cyanopyridone acceptor functionalities at the terminals. The influence of terminal units on optoelectronic and photovoltaic properties was studied. The target chromophore bearing cyanopyridone acceptor units (N6) afforded a power conversion efficiency of 6.10% when paired with the conventional donor polymer poly(3-hexylthiophene), a result that is the highest for the NDI core-based non-fullerene acceptors...
September 15, 2017: Chemical Communications: Chem Comm
Zhao-Feng Wu, Xiao-Ying Huang
Herein, the solvothermal preparations, crystal structures, and fluorescence properties of three Mg-Zn heterometallic coordination polymers (CPs), i.e. [Mg2Zn2(OH)2(1,4-NDC)3(H2O)2]·6H2O (1), [Mg1.13Zn1.87(1,4-NDC)3(dppe)(CH3OH)] (2), and [Mg1.17Zn1.83(1,4-NDC)3(py)2]·1.5py (3), based on the mixed ligands of 1,4-naphthalene dicarboxylic acid (1,4-H2NDC) and N-containing ligands of 1,3-di(4-pyridyl)propane (dppe) or pyridine (py) are presented. In the title compounds, Zn and Mg are statistically distributed, as confirmed by single crystal analysis, and the ratios of Zn and Mg have been identified by inductively coupled plasma (ICP) measurements...
September 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Wah-Seng See-Too, Robson Ee, Yan-Lue Lim, Peter Convey, David A Pearce, Taznim Begam Mohd Mohidin, Wai-Fong Yin, Kok Gan Chan
Arthrobacter alpinus R3.8 is a psychrotolerant bacterial strain isolated from a soil sample obtained at Rothera Point, Adelaide Island, close to the Antarctic Peninsula. Strain R3.8 was sequenced in order to help discover potential cold active enzymes with biotechnological applications. Genome analysis identified various cold adaptation genes including some coding for anti-freeze proteins and cold-shock proteins, genes involved in bioremediation of xenobiotic compounds including naphthalene, and genes with chitinolytic and N-acetylglucosamine utilization properties and also plant-growth-influencing properties...
2017: Standards in Genomic Sciences
Yan Zhou, Chao-Jie Wang, Chun-Chao Zhu, Jiang-Rong Chen, Ming Cheng, Yu-Liang Deng, Yan Guo
Single-cell analysis of heterogeneity has become the cutting-edge technology for profound understandings of relationships between cell populations. At present, common methods used in single cellular genomic research are mainly microfluidic technologies (Fluidigm) or based on microwells, both requiring a uniform size of cells at the entrance. However, the size of cells in specific tissues can vary from type to type. To address this issue, we need to establish a method to identify genomic features of individual cells of different sizes...
August 20, 2017: Yi Chuan, Hereditas
Xiyang Dong, Maik A Jochmann, Martin Elsner, Armin H Meyer, Leonard E Bäcker, Mona Rahmatullah, Daniel Schunk, Guido Lens, Rainer Udo Meckenstock
Assessing the biodegradation of organic compounds is a frequent question in environmental science. Here, we present a sensitive, inexpensive, and simple approach to monitor microbial mineralization using reverse stable isotope labelling analysis (RIL) of dissolved inorganic carbon (DIC). The medium for the biodegradation assay contains regular organic compounds and (13)C-labelled DIC with (13)C atom fractions (x((13)C)DIC) higher than natural abundance (typically 2-50%). The produced CO2 (x((13)C) ≈ 1.11%) gradually dilutes the initial x((13)C)DIC allowing to quantify microbial mineralization using mass-balance calculations...
September 14, 2017: Environmental Science & Technology
Meghan B Teunis, Mulpuri Nagaraju, Poulami Dutta, Jingzhi Pu, Barry B Muhoberac, Rajesh Sardar, Mangilal Agarwal
This article describes the mechanisms underlying electronic interactions between surface passivating ligands and (CdSe)34 semiconductor cluster molecules (SCMs) that facilitate band-gap engineering through the delocalization of hole wave functions without altering their inorganic core. We show here both experimentally and through density functional theory calculations that the expansion of the hole wave function beyond the SCM boundary into the ligand monolayer depends not only on the pre-binding energetic alignment of interfacial orbitals between the SCM and surface passivating ligands but is also strongly influenced by definable ligand structural parameters such as the extent of their π-conjugation [π-delocalization energy; pyrene (Py), anthracene (Anth), naphthalene (Naph), and phenyl (Ph)], binding mode [dithiocarbamate (DTC, -NH-CS2(-)), carboxylate (-COO(-)), and amine (-NH2)], and binding head group [-SH, -SeH, and -TeH]...
September 13, 2017: Nanoscale
Kazutaka Shoyama, David Schmidt, Magnus Mahl, Frank Würthner
Two new bowl-shaped polycyclic aromatic hydrocarbons, based on corannulene and naphthalene dicarboximide, are synthesized by an improved Suzuki-Miyaura cross-coupling and C-H arylation cascade reaction. Crystallographic analyses confirm structural assignments and provide insight into molecular interactions in the solid state. The new bowl-shaped molecules show reversible oxidation and reduction, intense visible range absorption, and high fluorescence quantum yields. These molecules can be considered bowl-shaped congeners of planar perylene dicarboximides...
September 13, 2017: Organic Letters
Abhirup Mookherjee, Paramita Bera, Adinpunya Mitra, Mrinal K Maiti
Plant-associated endophytes are recognized as sources of novel bioactive molecules having diverse applications. In this study, an endophytic yeast-like fungal strain was isolated from the fruit of eggplant (Solanum melongena) and identified as Geotrichum candidum through phenotypic and genotypic characterizations. This endophytic G. candidum isolate PF005 was found to emit fruity scented volatiles. The compositional profiling of volatile organic compounds (VOCs) revealed the presence of 3-methyl-1-butanol, ethyl 3-methylbutanoate, 2-phenylethanol, isopentyl acetate, naphthalene, and isobutyl acetate in significant proportion when analyzed on a time-course basis...
September 11, 2017: Microbial Ecology
Zhe Jiang, Shengbao Diao, Ren Li, Wei Zhou, Jinfeng Sun, Yi Zhou, Yong Jin, Mei Jin, Gao Li
A new 1,4-napthoquinone derivative, namely (S)-(-)-3-(8-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-3-(4-hydroxy-3-methoxyphenyl)-propionic acid methyl ester (1), was isolated from the roots of Juglans mandshurica Maxim. The structure was identified based on HR-ESI-MS, 1D and 2D NMR spectroscopic methods.
September 11, 2017: Natural Product Research
Aritra Sarkar, Shikha Dhiman, Aditya Chalishazar, Subi J George
Chirality driven self-sorting is envisaged to efficiently control functional properties in supramolecular materials. However, it faces challenge due to lack of analytical methods to directly monitor the enantioselectivity of resulting supramolecular assemblies. In this context, we present two fluorescent core-substituted naphthalene diimide based donor and acceptor molecules with minimal structural mismatch and comprising of strong self-recognizing chiral motif, for solely chirality to determine the self-sorting process...
September 11, 2017: Angewandte Chemie
Rukiya Matsidik, Alessandro Luzio, Özge Askin, Daniele Fazzi, Alessandro Sepe, Ullrich Steiner, Hartmut Komber, Mario Caironi, Michael Sommer
The synthesis, characterization, and charge transport performance of novel copolymers PNDIFu2 made from alternating naphthalene diimide (NDI) and bifuran (Fu2) units are reported. Usage of potentially biomass-derived Fu2 as alternating repeat unit enables flattened polymer backbones due to reduced steric interactions between the imide oxygens and Fu2 units, as seen by density functional theory (DFT) calculations and UV-vis spectroscopy. Aggregation of PNDIFu2 in solution is enhanced if compared to the analogous NDI-bithiophene (T2) copolymers PNDIT2, occurring in all solvents and temperatures probed...
July 11, 2017: Chemistry of Materials: a Publication of the American Chemical Society
Niranjan Das, Atanas G Atanasov, Prashanta Kumar Deb, Andrei Mocan, Seyed Mohammad Nabavi, Ranjib Ghosh, Biswanath Dinda
BACKGROUND: Neanotis wightiana (Wall. ex Wight & Arn) W.H. Lewis has been used in traditional medicine in India for the treatment of liver disorders. In fact, this plant is frequently used by the local people of Tripura for the treatment of liver disorder problems. In previous study on this plant we have isolated a hepatoprotective saponin, neanoside A. PURPOSE: Evaluation of in vivo hepatoprotective effects of isolated compounds from N. wightiana aerial parts on serum hepatic-biomarkers in CCl4- induced hepatotoxicity in rats to validate the traditional use of the plant...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Jing Wang, Jing Wang, Zelong Zhao, Jingwen Chen, Hong Lu, Guangfei Liu, Jiti Zhou, Xiaoyan Guan
Antibiotic resistance genes (ARGs) have been regarded as emerging contaminants and have attracted growing attention owing to their widespread presence in the environment. In addition to the well-documented selective pressure of antibiotics, ARGs have also become prevalent because of anthropogenic impacts. Coastal habitats are located between terrestrial and marine ecosystems, which are a hotspot for anthropogenic impacts. Excessive accumulation of polycyclic aromatic hydrocarbons (PAHs) has posed a serious threat to coastal habitats, but no information is available on the effect of PAHs on antibiotic resistance in the microbial community of coastal environments...
September 6, 2017: Environmental Pollution
Robert Schroot, Tina Schlotthauer, Benjamin Dietzek, Michael Jäger, Ulrich S Schubert
A bifunctional Ru(II) photosensitizer units was decorated with precisely one n- and one p-type polymer chain to form precisely controlled hierarchical copolymer-type architectures for light-induced charge separation. The applied modular chemistry-on-the-complex strategy benefits from separately prepared building blocks and their orthogonal linkage in the two final assembly steps. Upon visible light absorption, electron transfer is initiated between the conjugated poly(3,6-carbazole) chain and styrenic poly(naphthalene diimide) segments...
September 8, 2017: Chemistry: a European Journal
R Miandad, M A Barakat, M Rehan, A S Aburiazaiza, I M I Ismail, A S Nizami
This study aims to examine the catalytic pyrolysis of various plastic wastes in the presence of natural and synthetic zeolite catalysts. A small pilot scale reactor was commissioned to carry out the catalytic pyrolysis of polystyrene (PS), polypropylene (PP), polyethylene (PE) and their mixtures in different ratios at 450°C and 75min. PS plastic waste resulted in the highest liquid oil yield of 54% using natural zeolite and 50% using synthetic zeolite catalysts. Mixing of PS with other plastic wastes lowered the liquid oil yield whereas all mixtures of PP and PE resulted in higher liquid oil yield than the individual plastic feedstocks using both catalysts...
September 4, 2017: Waste Management
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