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Keywords Mitochondrial permeability tra...

Mitochondrial permeability transition pore

https://read.qxmd.com/read/38235549/mitochondrial-permeability-transition-pore-a-snapshot-of-a-therapeutic-target
#21
EDITORIAL
Mario Zoratti, Lucia Biasutto, Sofia Parrasia, Ildikó Szabo
No abstract text is available yet for this article.
January 18, 2024: Expert Opinion on Therapeutic Targets
https://read.qxmd.com/read/38212158/mitochondrial-dysfunction-in-the-pathogenesis-of-acute-pancreatitis
#22
REVIEW
Xia Chen, Rui Zhong, Bing Hu
The mechanism of cell damage during acute pancreatitis (AP) has not been fully elucidated, and there is still a lack of specific or effective treatments. Increasing evidence has implicated mitochondrial dysfunction as a key event in the pathophysiology of AP. Mitochondrial dysfunction is closely related to calcium (Ca2+ ) overload, intracellular adenosine triphosphate depletion, mitochondrial permeability transition pore openings, loss of mitochondrial membrane potential, mitophagy damage and inflammatory responses...
December 30, 2023: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/38202836/spinetoram-induced-potential-neurotoxicity-through-autophagy-mediated-by-mitochondrial-damage
#23
JOURNAL ARTICLE
Fan Chen, Jin Lu, Meng Li, Junwu Yang, Wenping Xu, Xufeng Jiang, Yang Zhang
Spinetoram is an important semi-synthetic insecticide extensively applied in agriculture. It is neurotoxic to insects, primarily by acting on acetylcholine receptors (nAChRs). However, few studies have examined the neurotoxicity of spinetoram in human beings. In this study, various concentrations (5, 10, 15, and 20 μM) of spinetoram were employed to expose SH-SY5Y cells in order to study the neurotoxic effects of spinetoram. The results showed that spinetoram exposure markedly inhibited cell viability and induced oxidative stress...
January 3, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38195584/cgas-sting-inflammasomes-and-pyroptosis-an-overview-of-crosstalk-mechanism-of-activation-and-regulation
#24
REVIEW
Jingwen Liu, Jing Zhou, Yuling Luan, Xiaoying Li, Xiangrui Meng, Wenhao Liao, Jianyuan Tang, Zheilei Wang
BACKGROUND: Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and pyroptosis act as critical natural immune signaling axes for microbial infection, chronic inflammation, cancer progression and organ degeneration, but the mechanism and regulation of the crosstalk network remain unclear. Cellular stress disrupts mitochondrial homeostasis, facilitates the opening of mitochondrial permeability transition pore and the leakage of mitochondrial DNA to cell membrane, triggers inflammatory responses by activating cGAS-STING signaling, and subsequently induces inflammasomes activation and the onset of pyroptosis...
January 9, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38195019/shuangshen-ningxin-formula-attenuates-cardiac-microvascular-ischemia-reperfusion-injury-through-improving-mitochondrial-function
#25
JOURNAL ARTICLE
ZiXin Liu, Xiao Han, Yue You, GaoJie Xin, LingMei Li, JiaMing Gao, HongXu Meng, Ce Cao, JianXun Liu, YeHao Zhang, Lei Li, JianHua Fu
ETHNOPHARMACOLOGICAL RELEVANCE: Shuangshen Ningxin Formula (SSNX) is a traditional Chinese medicine formula used to treat myocardial ischemia-reperfusion injury (MIRI). A randomized controlled trial previously showed that SSNX reduced cardiovascular events, and experiments have also verified that SSNX attenuated ischemia-reperfusion (I/R) injury. However, the mechanism of SSNX in the treatment of microvascular I/R injury is still unclear. AIM OF THE STUDY: To determine whether SSNX protects the microvasculature by regulating I/R induction in rats and whether this effect depends on the regulation of NR4A1/Mff/Drp1 pathway...
January 7, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38173217/quercetin-promotes-the-repair-of-mitochondrial-function-in-h9c2-cells-through-the-mir-92a-3p-mfn1-axis
#26
JOURNAL ARTICLE
Fen Li, Dongsheng Li, Xisheng Yan, Fen Zhu, Shifan Tang, Jianguang Liu, Jie Yan, Haifeng Chen
OBJECTIVE: Cardiocerebrovascular disease is a severe threat to human health. Quercetin has a wide range of pharmacological effects such as antitumor and antioxidant. In this study, we aimed to determine how quercetin regulates mitochondrial function in H9c2 cells. METHODS: An H9c2 cell oxygen glucose deprivation/reoxygenation (OGD/R) model was constructed. The expression of miR-92a-3p and mitofusin 1 (Mfn1) mRNA in the cells was detected using reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
January 3, 2024: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/38165883/direct-toxicity-of-cigarette-smoke-extract-on-cardiac-function-mediated-by-mitochondrial-dysfunction-in-sprague-dawley-rat-ventricular-myocytes-and-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#27
JOURNAL ARTICLE
Sakiko Matsumura, Jumpei Yasuda, Takuya Notomi, Yoshihiro Suzuki, I-Shan Chen, Daichi Murakami, Muneki Hotomi, Tomoe Y Nakamura
Cigarette smoke has been recognized as a major risk factor for cardiovascular disease. However, its direct effects on rodent and human cardiomyocytes and its cellular mechanisms are not fully understood. In this study, we examined the direct effects of cigarette smoke extract (CSE) on contractile functions, intracellular Ca2+ dynamics, and mitochondrial function using cultured or freshly isolated rat ventricular myocytes and human induced pluripotent stem cell (iPS)-derived cardiomyocytes. In rat cardiomyocytes, CSE (≥0...
2024: PloS One
https://read.qxmd.com/read/38164154/reprogramming-exosomes-to-escape-from-immune-surveillance-for-mitochondrial-protection-in-hepatic-ischemia-reperfusion-injury
#28
JOURNAL ARTICLE
Shanshan Liu, Xinyu Xiao, La Zhang, Jianwei Wang, Wei Zhao, Haichuan Liu, Rui Liao, Zhi Li, Mengxia Xu, Jiao Guo, Baoyong Zhou, Chengyou Du, Qiling Peng, Ning Jiang
Background: Therapeutic interventions such as synthetic drugs and microRNA (miR) modulators have created opportunities for mitigating hepatic ischemia/reperfusion injury (HIRI) by alleviating mitochondrial dysfunction. However, delivering multi-therapeutic ingredients with low toxicity to hepatocytes still lags behind its development. Methods: In this study, we endowed exosomes with delivery function to concentrate on hepatocytes for multidimensionally halting mitochondria dysfunction during HIRI. Concretely, exosomes were reprogrammed with a transmembrane protein CD47, which acted as a "camouflage cloak" to mimic the "don't eat me" mechanism to escape from immune surveillance...
2024: Theranostics
https://read.qxmd.com/read/38149060/mechanistic-engineering-of-celastrol-liposomes-induces-ferroptosis-and-apoptosis-by-directly-targeting-vdac2-in-hepatocellular-carcinoma
#29
JOURNAL ARTICLE
Piao Luo, Qian Zhang, Shuo Shen, Yehai An, Lixia Yuan, Yin-Kwan Wong, Sizhe Huang, Shaohui Huang, Jingnan Huang, Guangqing Cheng, Jiahang Tian, Yu Chen, Xiaoyong Zhang, Weiguang Li, Songqi He, Jigang Wang, Qingfeng Du
Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. Celastrol (Cel), a natural product derived from the Tripterygium wilfordii plant, has been extensively researched for its potential effectiveness in fighting cancer. However, its clinical application has been hindered by the unclear mechanism of action. Here, we used chemical proteomics to identify the direct targets of Cel and enhanced its targetability and anti-tumor capacity by developing a Cel-based liposomes in HCC. We demonstrated that Cel selectively targets the voltage-dependent anion channel 2 (VDAC2)...
November 2023: Asian journal of pharmaceutical sciences
https://read.qxmd.com/read/38148906/neither-too-much-nor-too-little-mitochondrial-calcium-concentration-as-a-balance-between-physiological-and-pathological-conditions
#30
REVIEW
Donato D'Angelo, Denis Vecellio Reane, Anna Raffaello
Ca2+ ions serve as pleiotropic second messengers in the cell, regulating several cellular processes. Mitochondria play a fundamental role in Ca2+ homeostasis since mitochondrial Ca2+ (mitCa2+ ) is a key regulator of oxidative metabolism and cell death. MitCa2+ uptake is mediated by the mitochondrial Ca2+ uniporter complex (MCUc) localized in the inner mitochondrial membrane (IMM). MitCa2+ uptake stimulates the activity of three key enzymes of the Krebs cycle, thereby modulating ATP production and promoting oxidative metabolism...
2023: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/38146639/new-cyclophilin-d-inhibitor-rescues-mitochondrial-and-cognitive-function-in-alzheimer-s-disease
#31
JOURNAL ARTICLE
Sourav Samanta, Firoz Akhter, Anuradha Roy, Doris Chen, Benjamin Turner, Yongfu Wang, Nicolina Clemente, Chunyu Wang, Russell Howard Swerdlow, Kevin P Battaile, Scott Lovell, Shi Fang Yan, Shirley ShiDu Yan
Mitochondrial dysfunction is an early pathological feature of Alzheimer disease (AD) and plays a crucial role in the development and progression of AD. Strategies to rescue mitochondrial function and cognition remain to be explored. Cyclophilin D (CypD), the peptidylprolyl isomerase F (PPIase), is a key component in opening the mitochondrial membrane permeability transition pore (mPTP), leading to mitochondrial dysfunction and cell death. Blocking mPTP opening by inhibiting CypD activity is a promising therapeutic approach for AD...
December 26, 2023: Brain
https://read.qxmd.com/read/38141489/nano-plastics-and-gastric-health-decoding-the-cytotoxic-mechanisms-of-polystyrene-nano-plastics-size
#32
JOURNAL ARTICLE
Mingming Han, Tian Zhu, Ji Liang, Hong Wang, Chenxi Zhu, Anisah Lee Binti Abdullah, James Rubinstein, Richard Worthington, Andrew George, Yiming Li, Wei Qin, Qichen Jiang
Gastrointestinal diseases exert a profound impact on global health, leading to millions of healthcare interventions and a significant number of fatalities annually. This, coupled with escalating healthcare expenditures, underscores the need for identifying and addressing potential exacerbating factors. One emerging concern is the pervasive presence of microplastics and nano-plastics in the environment, largely attributed to the indiscriminate usage of disposable plastic items. These nano-plastics, having infiltrated our food chain, pose a potential threat to gastrointestinal health...
December 11, 2023: Environment International
https://read.qxmd.com/read/38136242/reactive-oxygen-species-damage-bovine-endometrial-epithelial-cells-via-the-cytochrome-c-mptp-pathway
#33
JOURNAL ARTICLE
Pengjie Song, Mingkun Sun, Chen Liu, Jianguo Liu, Pengfei Lin, Huatao Chen, Dong Zhou, Keqiong Tang, Aihua Wang, Yaping Jin
After parturition, bovine endometrial epithelial cells (BEECs) undergo serious inflammation and imbalance between oxidation and antioxidation, which is widely acknowledged as a primary contributor to the development of endometritis in dairy cows. Nevertheless, the mechanism of oxidative stress-mediated inflammation and damage in bovine endometrial epithelial cells remains inadequately defined, particularly the molecular pathways associated with mitochondria-dependent apoptosis. Hence, the present study was designed to explore the mechanism responsible for mitochondrial dysfunction-induced BEEC damage...
December 16, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38133921/dynamin-related-protein-1-is-a-critical-regulator-of-mitochondrial-calcium-homeostasis-during-myocardial-ischemia-reperfusion-injury
#34
JOURNAL ARTICLE
Lin Piao, Yong-Hu Fang, Michael Fisher, Robert B Hamanaka, Alaa Ousta, Rongxu Wu, Gökhan M Mutlu, Alfredo J Garcia, Stephen L Archer, Willard W Sharp
Dynamin-related protein 1 (Drp1) is a cytosolic GTPase protein that when activated translocates to the mitochondria, meditating mitochondrial fission and increasing reactive oxygen species (ROS) in cardiomyocytes. Drp1 has shown promise as a therapeutic target for reducing cardiac ischemia/reperfusion (IR) injury; however, the lack of specificity of some small molecule Drp1 inhibitors and the reliance on the use of Drp1 haploinsufficient hearts from older mice have left the role of Drp1 in IR in question. Here, we address these concerns using two approaches, using: (a) short-term (3 weeks), conditional, cardiomyocyte-specific, Drp1 knockout (KO) and (b) a novel, highly specific Drp1 GTPase inhibitor, Drpitor1a...
January 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38123539/mtfp1-ablation-enhances-mitochondrial-respiration-and-protects-against-hepatic-steatosis
#35
JOURNAL ARTICLE
Cecilia Patitucci, Juan Diego Hernández-Camacho, Elodie Vimont, Sonny Yde, Thomas Cokelaer, Thibault Chaze, Quentin Giai Gianetto, Mariette Matondo, Anastasia Gazi, Ivan Nemazanyy, David A Stroud, Daniella H Hock, Erminia Donnarumma, Timothy Wai
Hepatic steatosis is the result of imbalanced nutrient delivery and metabolism in the liver and is the first hallmark of Metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD is the most common chronic liver disease and involves the accumulation of excess lipids in hepatocytes, inflammation, and cancer. Mitochondria play central roles in liver metabolism yet the specific mitochondrial functions causally linked to MASLD remain unclear. Here, we identify Mitochondrial Fission Process 1 protein (MTFP1) as a key regulator of mitochondrial and metabolic activity in the liver...
December 20, 2023: Nature Communications
https://read.qxmd.com/read/38114222/-muscone-inhibits-opening-of-mptp-to-alleviate-ogd-r-induced-injury-of-ht22-cells
#36
JOURNAL ARTICLE
Ping Huang, Mei-Ling Yuan, Lei Wang, Yu-Ang Chen, Ning Wang, Si-Peng Wu
This study aims to investigate the mechanism of muscone in inhibiting the opening of mitochondrial permeability transition pore(mPTP) to alleviate the oxygen and glucose deprivation/reoxygenation(OGD/R)-induced injury of mouse hippocampal neurons(HT22). An in vitro model of HT22 cells injured by OGD/R was established. CCK-8 assay was employed to examine the viability of HT22 cells, fluorescence microscopy to measure the mitochondrial membrane potential, the content of reactive oxygen species(ROS), and the opening of mPTP in HT22 cells...
November 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38105501/the-dynamic-relationship-between-inorganic-polyphosphate-and-adenosine-triphosphate-in-human-non-small-cell-lung-cancer-h1299-cells
#37
JOURNAL ARTICLE
Kaori Tsutsumi, Thititip Tippayamontri, Mari Hayashi, Nobuto Matsuda, Yusaku Goto
Inorganic polyphosphate (polyP) plays a vital role in cellular energy metabolism and signaling, owing to its structure and high-energy phosphate bonds. Intracellular ATP functions both as a cellular energy source and a key factor in cell death, and ATP dynamics in tumor cells are crucial for advancing cancer therapy. In this study, we explored the interplay between polyP and ATP in cellular energy metabolism. Treatment with polyP did not affect cell proliferation of human non-small cell lung cancer H1299 and human glioblastoma T98G cell lines as compared to their respective control cells until 72 h post-treatment...
December 17, 2023: FEBS Open Bio
https://read.qxmd.com/read/38094013/isolation-characterization-and-modulatory-potentials-of-%C3%AE-stigmasterol-ergosterol-and-xylopic-acid-from-anchomanes-difformis-on-mitochondrial-permeability-transition-pore-in-vitro
#38
JOURNAL ARTICLE
Kehinde Oluseun Sodeinde, Akinwunmi Oluwaseun Adeoye, Adedeji Adesipo, Adebayo A Adeniyi, John Adeolu Falode, Tajudeen Olabisi Obafemi, Samuel Olalekan Olusanya, Linette Twigge, Jeanet Conradie, Timothy O Mosaku
OBJECTIVE: Secondary metabolites and polyphenolic compounds from medicinal plants have been demonstrated to have multiple biological functions with promising research and development prospects. This study examined the effect of β -stigmasterol (with ergosterol) and xylopic acid isolated from Anchomanes difformis on liver mitochondrial permeability transition pore (mPTP). METHODS: The compounds were isolated by vacuum liquid chromatography. Mitochondrial swelling was assessed as changes in absorbance under succinate-energized conditions...
October 2023: Chinese Herbal Medicines
https://read.qxmd.com/read/38093654/pharmaceutical-manipulation-of-mitochondrial-f0f1-atp-synthase-enables-imaging-and-protection-of-myocardial-ischemia-reperfusion-injury-through-stress-induced-selective-enrichment
#39
JOURNAL ARTICLE
Zelin Chen, Xu Tan, Taotao Jin, Yu Wang, Linyong Dai, Gufang Shen, Can Zhang, Langfan Qu, Lei Long, Chongxing Shen, Xiaohui Cao, Jianwu Wang, Huijuan Li, Xiaofeng Yue, Chunmeng Shi
To rescue ischemic myocardium from progressing to myocardial infarction, timely identification of the infarct size and reperfusion is crucial. However, fast and accurate identification, as well as the targeted protection of injured cardiomyocytes following ischemia/reperfusion (I/R) injury, remain significantly challenging. Here, a near infrared heptamethine dye IR-780 is shown that has the potential to quickly monitor the area at risk following I/R injury by selectively entering the cardiomyocytes of the at-risk heart tissues...
December 14, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38091291/the-mitochondrial-atp-synthase-is-a-negative-regulator-of-the-mitochondrial-permeability-transition-pore
#40
JOURNAL ARTICLE
Ryan Pekson, Felix G Liang, Joshua L Axelrod, Jaehoon Lee, Dongze Qin, Andre J H Wittig, Victor M Paulino, Min Zheng, Pablo M Peixoto, Richard N Kitsis
The mitochondrial permeability transition pore (mPTP) is a channel in the inner mitochondrial membrane whose sustained opening in response to elevated mitochondrial matrix Ca2+ concentrations triggers necrotic cell death. The molecular identity of mPTP is unknown. One proposed candidate is the mitochondrial ATP synthase, whose canonical function is to generate most ATP in multicellular organisms. Here, we present mitochondrial, cellular, and in vivo evidence that, rather than serving as mPTP, the mitochondrial ATP synthase inhibits this pore...
December 19, 2023: Proceedings of the National Academy of Sciences of the United States of America
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