Jordi Bover, Pedro Trinidad, Aquiles Jara, Jordi Soler-Majoral, Alejandro Martín-Malo, Armando Torres, João Frazão, Pablo Ureña, Adriana Dusso, Carolt Arana, Fredzzia Graterol, Gregorio Romero-González, Maribel Troya, Diana Samaniego, Luis D'Marco, José Manuel Valdivielso, Elvira Fernández, María Dolores Arenas, Vicente Torregrosa, Juan F Navarro-González, María Jesús Lloret, J A Ballarín, Ricardo J Bosch, José L Górriz, Agl de Francisco, Orlando Gutiérrez, Jordi Ara, Arnold Felsenfeld, Antonio Canalejo, Yolanda Almadén
Although phosphorus is an essential element for life, it is not found in nature in its native state but rather combined in the form of inorganic phosphates (PO4 3- ), with tightly regulated plasma levels that are associated with deleterious effects and mortality when these are out of bounds. The growing interest in the accumulation of PO4 3- in human pathophysiology originated in its attributed role in the pathogenesis of secondary hyperparathyroidism (SHPT) in chronic kidney disease. In this article, we review the mechanisms by which this effect was justified and we commemorate the important contribution of a Spanish group led by Dr...
March 14, 2023: Nefrología