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Fesoterodine

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https://www.readbyqxmd.com/read/28060912/early-fesoterodine-fumarate-administration-prevents-neurogenic-detrusor-overactivity-in-a-spinal-cord-transected-rat-model
#1
Xavier Biardeau, Mikolaj Przydacz, Shachar Aharony, George Loutochin, Lysanne Campeau, Maeva Kyheng, Jacques Corcos
BACKGROUND: In spinal cord injury, onset of detrusor overactivity (DO) is detrimental for quality of life (incontinence) and renal risk. Prevention has only been achieved with complex sophisticated electrical neuromodulation techniques. PURPOSE: To assess the efficacy of early fesoterodine fumarate (FF) administration in preventing bladder overactivity in a spinal cord transected (SCT) rat model. METHODS: 33 Sprague-Dawley rats were allocated to 6 groups-Group 1: 3 normal controls; Group 2: 6 SCT controls; Group 3: 6 SCT rats + FF 0...
2017: PloS One
https://www.readbyqxmd.com/read/28057620/a-pooled-analysis-of-the-efficacy-of-fesoterodine-for-the-treatment-of-overactive-bladder-and-the-relationship-between-safety-co-morbidity-and-polypharmacy-in-patients-aged-65-years-or-older
#2
Adrian Wagg, Daniel Arumi, Sender Herschorn, Javier Angulo Cuesta, Francois Haab, Fady Ntanios, Martin Carlsson, Matthias Oelke
BACKGROUND: overactive bladder (OAB) is a common condition in older persons. Antimuscarinic treatment remains the mainstay of treatment of OAB but clinicians have been reluctant to prescribe this to older patients. This study examined efficacy and safety information from patients >65 in fesoterodine trials to reaffirm efficacy and to explore the relationships between treatment emergent adverse events (TEAEs), coexisting medication and co-morbidity. METHODS: data from 10 double-blind, placebo-controlled studies were analysed...
January 4, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28042791/profile-of-oab-patient-on-treatment-with-flexible-dose-antimuscarinic-drugs-in-daily-clinical-practice
#3
Francisco Sánchez-Ballester, Jose María García-Mediero, Marcos Sobrón-Bustamante, Isabel Lizarraga, Daniel Arumi
OBJECTIVE: To describe the profile of the overactive bladder (OAB) patient on treatment with flexible-dose antimuscarinic treatment in daily clinical practice. METHODS: This was an observational, retrospective and multicenter study, carried out at 88 public and private hospitals. Adult patients diagnosed with OAB who initiated flexible-dose antimuscarinic treatment. Type of antimuscarinic, dose, concomitant treatments, treatment benefit and treatment adherence were recorded...
December 2016: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28025920/impact-of-overactive-bladder-step-therapy-policies-on-medication-utilization-and-expenditures-among-treated-medicare-members
#4
Ibrahim M Abbass, Eleanor O Caplan, Daniel B Ng, Rita Kristy, Carol R Schermer, Pamela Bradt, Jenna M Collins, Wai Man Maria Chan, Brandon T Suehs
BACKGROUND: The impact of formulary management strategies on utilization and expenditures in overactive bladder (OAB) treatment has not been extensively investigated. In 2013, step therapy (ST) policies for 2 branded OAB treatments, mirabegron and fesoterodine, were removed from Humana Medicare Advantage Prescription Drug (MAPD) plans and Medicare prescription drug plans (PDP), allowing for an examination of the effect of ST policies on OAB medication use patterns and costs. OBJECTIVE: To assess the impact of removal of formulary restriction policies for mirabegron and fesoterodine on medication utilization patterns and costs associated with OAB treatment in Medicare patients...
January 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27889591/adverse-events-and-treatment-discontinuations-of-antimuscarinics-for-the-treatment-of-overactive-bladder-in-older-adults-a-systematic-review-and-meta-analysis
#5
REVIEW
Scott Martin Vouri, Clark D Kebodeaux, Paul M Stranges, Besu F Teshome
INTRODUCTION: Antimuscarinics should be used with caution in older adults with overactive bladder (OAB) due to anticholinergic adverse events (AEs). Systematic reviews and meta-analyses (SRMAs) have analyzed safety-related outcomes but have not specified risk in the elderly, the population at highest risk for AEs. The aim of this review is to explore and evaluate AEs and treatment discontinuations in adults 65 or older taking antimuscarinics for OAB. METHODS: Keywords were searched in MEDLINE, EMBASE, SCOPUS, and Cochrane Central Register for Controlled Trials...
March 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27738922/a-short-review-of-drug-food-interactions-of-medicines-treating-overactive-bladder-syndrome
#6
Paweł Paśko, Tomasz Rodacki, Renata Domagała-Rodacka, Danuta Owczarek
Background Overactive bladder syndrome is a condition where one or more of the symptoms such as pollakiuria, urgent need to urinate, nocturia and urinary incontinence is observed. Its prevalence ranges between 7 and 27 % in men and 9-43 % in women. The role of a pharmacist is to educate the patient on medications administration scheme, and drug interactions with particular food or food components. Aim of the review To assess a potential impact of food and fruit juice on the pharmacokinetic and therapeutic effects of medications used in treating overactive bladder syndrome...
December 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27713646/cost-effectiveness-analysis-of-fesoterodine-flexible-dose-in-newly-diagnosed-patients-with-overactive-bladder-in-routine-clinical-practice-in-spain
#7
Carmen Peral, Francisco Sánchez-Ballester, José M García-Mediero, Jaime Ramos, Javier Rejas
OBJECTIVE: To carry out cost-effectiveness analysis from the Spanish National Health System perspective, of treating overactive bladder (OAB), in newly diagnosed patients with two flexible doses of fesoterodine in routine clinical practice. PATIENTS AND METHODS: Economic evaluation of flexible-dose fesoterodine in newly diagnosed patients, including two treatment groups: standard escalating from 4 to 8 mg or fast escalating to 8 mg. Costs were estimated from health care resources utilization related to OAB, and were expressed in 2015 Euros...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/27687744/development-of-a-predictive-model-for-urgency-urinary-incontinence
#8
Amanda Darekar, Martin Carlsson, Sheila Quinn, Fady Ntanios, Erin Mangan, Daniel Arumi, David Scholfield
The ability to set realistic expectations of treatment response in patients with overactive bladder (OAB) can have an impact on patient engagement and adherence to study medication. In order to help set treatment expectations for OAB, a Physician Predictive Tool has been developed based on predictive modelling. Models have been developed utilizing data from eight Phase 3 and 4 fesoterodine clinical trials and these models enable the prediction of individual treatment response in subjects with OAB, based on various baseline characteristics...
September 27, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27681493/new-treatment-strategies-for-benign-prostatic-hyperplasia-in-the-frail-elderly-population-a-systematic-review
#9
Simone Albisinni, Fouad Aoun, Thierry Roumeguère, Francesco Porpiglia, Andrea Tubaro, Cosimo De Nunzio
Life expectancy is constantly increasing and as a consequence older men, frequently with multiple comorbidities, are seeking treatment for benign prostatic hyperplasia. Given their frail health, these men need extreme attention in their management, as efficacious and safe treatment strategies in the general population may not be adequate for them. Across medications, α1-antagonists should be used with caution given the risk of orthostatic hypotension and consequent falls, cause of significant morbidity in the elderly...
September 28, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27564470/personal-goals-and-expectations-of-oab-patients-in-the-uk
#10
Angie Rantell, Linda Cardozo, Vik Khullar
INTRODUCTION: In clinical practice and in research patient-centred outcomes are often utilised to help improve communication between patients and clinicians and to help manage expectations from treatment. However, many of these goals are generic and do not adequately capture the details of day to day life that bother patients the most and that they hope will improve with therapy. This study aimed to understand what are the goals of patients with overactive bladder symptoms in the UK who were taking part in a clinical trial and to assess goal achievement...
August 26, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27241452/an-integrative-review-of-standardized-clinical-evaluation-tool-utilization-in-anticholinergic-drug-trials-for-neurogenic-lower-urinary-tract-dysfunction
#11
L Stothers, B Tsang, M Nigro, D Lazare, A Macnab
STUDY DESIGN: To review prospective and randomized trials studying anticholinergic therapy for neurogenic bladder in SCI to identify whether trials included standardized clinical evaluation tools and reporting measures now recognized to enhance clinical trial data. METHODS: A systematic search via EMBASE, MEDLINE, CENTRAL, CINAHL (Cumulative Index to Nursing and Allied Health Literature), HTA (Health Technology Assessment), CMR (Comprehensive Microbial Resource), HAPI (Health and Psychosocial Instruments) and PsycINFO using the key term spinal cord injury crossed with oxybutynin, tolterodine, darifenacin, solifenacin, fesoterodine, trospium chloride, propiverine, propantheline and anticholinergic(s) for 1946-2015 inclusive...
December 2016: Spinal Cord
https://www.readbyqxmd.com/read/27135856/the-impact-of-treatment-of-overactive-bladder-on-physical-activity-limitations
#12
Christine M Chu, Heidi S Harvie, Ariana L Smith, Lily A Arya, Uduak U Andy
PURPOSE: To determine if treatment of overactive bladder (OAB) can improve self-reported limitations in physical activity in women. MATERIALS AND METHODS: This is a prospective study of women with OAB treated with flexible-dose fesoterodine therapy and standardized behavioral counseling. Subjects were evaluated at baseline and 8 weeks post-treatment. Physical activity scores were assigned using two questions of the Short Form 12 (SF-12) and categorized into three levels of physical activity (no limitations, moderate limitations, severe limitations)...
August 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27046653/safety-and-efficacy-of-fesoterodine-fumarate-in-patients-with-overactive-bladder-results-of-a-post-marketing-surveillance-study-in-korea
#13
Tae Heon Kim, Sang Eun Lee, Hahn-Ey Lee, Kyu-Sung Lee
OBJECTIVES: The aim of this study was to evaluate the safety and efficacy of fesoterodine fumarate (fesoterodine; Toviaz ) in Korean patients with overactive bladder (OAB) in routine clinical practice. METHODS: This was an open-label, non-interventional, prospective, post-marketing surveillance study submitted to the Korean Ministry of Food and Drug Safety. A total of 3109 patients aged ≥18 years with OAB symptoms were prescribed flexible doses of fesoterodine at the investigator's discretion...
August 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26988624/cost-effectiveness-analysis-of-fesoterodine-compared-to-mirabegron-in-first-line-therapy-setting-for-overactive-bladder-with-urge-urinary-incontinence-from-the-spanish-national-health-system-perspective
#14
J C Angulo, F Sánchez-Ballester, C Peral, J Rejas, J Ramos, S J Snedecor, L Sudharshan, S Liu, X Luo
OBJECTIVES: To evaluate the cost-effectiveness of first-line treatment of Overactive Bladder (OAB) with fesoterodine relative to mirabegron, from the Spanish National Health System (NHS) perspective. METHODS: A decision tree model was developed to represent a typical clinical process of 52-week of treatment for an OAB patient with urge urinary incontinence (UUI) initiating first-line therapy with fesoterodine 4mg, including optional titration to 8mg, vs.mirabegron 50mg...
October 2016: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/26886709/-pharmacotherapy-of-urinary-incontinence-in-the-elderly
#15
K F Becher
The prevalence and the incidence of Urinary Incontinence is growing. Women suffer predominantly from stress and mixed urinary incontinence and men from urge incontinence. In elderly people, the pathophysiological and the physiological change in the lower urinary tract system must be considered as well as an underlying multimorbidity. Stress urinary incontinence is among others caused by an insufficient urethral closure mechanism and urge incontinence is followed by unhibited detrusor contractions. Medical treatment is beside other important conservative options only one part of the treatment strategy in incontinence...
April 2016: Der Internist
https://www.readbyqxmd.com/read/26883688/the-concomitant-use-of-fesoterodine-and-topical-vaginal-estrogen-in-the-management-of-overactive-bladder-and-sexual-dysfunction-in-postmenopausal-women
#16
RANDOMIZED CONTROLLED TRIAL
Bilal Chughtai, James C Forde, Jessica Buck, Tirsit Asfaw, Richard Lee, Alexis E Te, Steven A Kaplan
OBJECTIVE: The objective of this study is to investigate the combination effect of anti-muscarinic medication and topical vaginal estrogen in the treatment of overactive bladder (OAB) and female sexual dysfunction in postmenopausal women. STUDY DESIGN: After IRB approval, 23 female subjects who met the entry criteria were randomized into two groups: (1) fesoterodine (Toviaz®, Pfizer, NY) with topical vaginal estrogen (Premarin®, Pfizer, NY) once daily or (2) fesoterodine once daily alone...
March 2016: Post Reproductive Health
https://www.readbyqxmd.com/read/26828974/oral-pharmacotherapy-for-overactive-bladder-in-older-patients-mirabegron-as-a-potential-alternative-to-antimuscarinics
#17
REVIEW
Adrian Wagg, Victor W Nitti, Con Kelleher, David Castro-Diaz, Emad Siddiqui, Todd Berner
OBJECTIVE: Overactive bladder (OAB) is a particular challenge to treat in older adults with co-morbid conditions taking multiple medications. Antimuscarinics (e.g., solifenacin, fesoterodine) and β3-adrenergic receptor agonists (mirabegron) are similarly efficacious; however, antimuscarinics may be associated with side effects that result in poor persistence and contribute to anticholinergic burden, particularly in those taking other medications with anticholinergic properties. With a mechanism of action distinct from antimuscarinics, mirabegron has a different tolerability profile and does not contribute to anticholinergic burden...
2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26682757/impact-of-dry-mouth-on-fluid-intake-and-overactive-bladder-symptoms-in-women-taking-fesoterodine
#18
RANDOMIZED CONTROLLED TRIAL
Steven J Weissbart, Rusell Lewis, Ariana L Smith, Heidi S Harvie, Janis M Miller, Lily A Arya
PURPOSE: We investigated the long-term relationships between dry mouth, fluid intake and overactive bladder symptoms in women undergoing treatment with fesoterodine. We hypothesized that women who experienced dry mouth would increase their fluid intake and worsen their urinary symptoms. MATERIALS AND METHODS: We conducted a prospective ancillary study to a 9-month open-label trial of fesoterodine for women with urgency urinary incontinence. Fluid intake was measured and compared according to reported dry mouth...
May 2016: Journal of Urology
https://www.readbyqxmd.com/read/26676351/efficacy-safety-and-tolerability-of-fesoterodine-in-asian-patients-with-overactive-bladder
#19
Osamu Yamaguchi, Osamu Nishizawa, Masayuki Takeda, Masaki Yoshida, Myung-Soo Choo, Jeong Gu Lee, Alex Tong-Long Lin, Ho-Hsiung Lin, Wai-Chun Andrew Yip, Hitoshi Isowa, Shintaro Hiro
OBJECTIVES: To assess the efficacy, safety, and tolerability of fesoterodine 4 and 8 mg once daily (QD) compared with placebo in Asian subjects with overactive bladder (OAB) after 12 weeks of treatment. METHODS: This phase II, dose-finding study consisted of a 2-week placebo run-in period followed by a 12-week, randomized, double-blind, placebo-controlled, treatment period. Eligible subjects were aged ≥20 years with ≥8 micturitions per 24 h and ≥1 urgency urinary incontinence (UUI) episodes per 24 h reported in a 3-day diary...
April 2011: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/26556482/persistence-and-concomitant-medication-in-patients-with-overactive-bladder-treated-with-antimuscarinic-agents-in-primary-care-an-observational-baseline-study
#20
A Sicras-Mainar, R Navarro-Artieda, A Ruiz-Torrejón, M Sáez-Zafra, G Coll-de Tuero
OBJECTIVE: To assess therapeutic persistence and its relationship with concomitant medication in patients treated with fesoterodine versus tolterodine and solifenacin for overactive bladder (OAB) in standard clinical practice conditions. MATERIAL AND METHODS: An observational, multicentre retrospective study was performed based on medical registries of patients followed-up in primary care (PC). Three study groups were analysed. Persistence was defined as the time (in months) without withdrawing from the initial therapy or without changing to another medication for at least 30 days after the initial prescription...
March 2016: Actas Urologicas Españolas
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