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JOURNAL ARTICLE
Bhavna Gupta, Akash Saxena, Mason L Perillo, Lauren C Wade-Kleyn, Cort H Thompson, Erin K Purcell
ConspectusImplantable neurotechnology enables monitoring and stimulating of the brain signals responsible for performing cognitive, motor, and sensory tasks. Electrode arrays implanted in the brain are increasingly used in the clinic to treat a variety of sources of neurological diseases and injuries. However, the implantation of a foreign body typically initiates a tissue response characterized by physical disruption of vasculature and the neuropil as well as the initiation of inflammation and the induction of reactive glial states...
April 17, 2024: Accounts of Chemical Research
#2
JOURNAL ARTICLE
Terry P Gao, Rebecca L Green, Lindsay E Kuo
INTRODUCTION: Adrenalectomy generally has favorable outcomes. It is unknown if patients with functional adrenal tumors experience different clinical outcomes than those with benign adrenal tumors, due to the presence of comorbid conditions secondary to the functional tumor. We investigated outcomes following open and laparoscopic adrenalectomy for benign nonfunctional (BNF) versus functional adrenal masses. METHODS: Patients undergoing adrenalectomy were identified in the 2015-2020 National Surgical Quality Improvement Program database, then categorized as BNF, hyperaldosteronism, hypercortisolism, and pheochromocytoma...
April 15, 2024: Journal of Surgical Research
#3
JOURNAL ARTICLE
Jonatan D Lindh, Jekaterina Patrova, Buster Mannheimer, Henrik Falhammar
IMPORTANCE: It is unclear whether nonfunctional adrenal tumors (NFATs) are associated with fractures. OBJECTIVE: To analyze fracture frequencies in individuals with NFATs. DESIGN, SETTING, AND PARTICIPANTS: A national retrospective cohort study was conducted in patients with NFATs diagnosed in Sweden between January 1, 2005, and December 31, 2019, and control participants without adrenal tumors followed up until death or the end of 2019. Individuals with a diagnosis of adrenal hormonal excess or previous malignant tumors were excluded...
April 1, 2024: JAMA Network Open
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JOURNAL ARTICLE
Susumu Hijioka, Daiki Yamashige, Minoru Esaki, Goro Honda, Ryota Higuchi, Toshihiko Masui, Yasuhiro Shimizu, Masayuki Ohtsuka, Yusuke Kumamoto, Akio Katanuma, Naoto Gotohda, Hirofumi Akita, Michiaki Unno, Itaru Endo, Yukihiro Yokoyama, Suguru Yamada, Ippei Matsumoto, Takao Ohtsuka, Satoshi Hirano, Hiroaki Yasuda, Manabu Kawai, Taku Aoki, Masafumi Nakamura, Daisuke Hashimoto, Toshiki Rikiyama, Akihiko Horiguchi, Tsutomu Fujii, Shugo Mizuno, Keiji Hanada, Masaji Tani, Takashi Hatori, Tetsuhide Ito, Masataka Okuno, Shingo Kagawa, Hiroshi Tajima, Tatsuya Ishii, Motokazu Sugimoto, Shunsuke Onoe, Hideki Takami, Ryoji Takada, Takayuki Miura, Yusuke Kurita, Keiko Kamei, Yuko Mataki, Kazuichi Okazaki, Yoshifumi Takeyama, Hiroki Yamaue, Sohei Satoi
BACKGROUND & AIMS: Despite previously reported treatment strategies for nonfunctioning small (≤20 mm) pancreatic neuroendocrine neoplasms (pNENs), uncertainties persist. We aimed to evaluate the surgically resected cases nonfunctioning small pNENs (NF-spNENs) in a large Japanese cohort to elucidate an optimal treatment strategy for NF-spNENs. METHODS: In this Japanese multicenter study, data were retrospectively collected from patients who underwent pancreatectomy between January 1996 and December 2019, were pathologically diagnosed with pNEN, and were treated according to the WHO 2019 classification...
April 12, 2024: Clinical Gastroenterology and Hepatology
#5
JOURNAL ARTICLE
Yun-Chen Chang, Yu-Ning Tsao, Chi-Cheng Chuang, Cheng-Yu Li, Ta-Jen Lee, Chia-Hsiang Fu, Kuo-Chen Wei, Chi-Che Huang
(1) Background: Transsphenoidal pituitary surgery can be conducted via microscopic or endoscopic approaches, and there has been a growing preference for the latter in recent years. However, the occurrence of rare complications such as postoperative sinusitis remains inadequately documented in the existing literature. (2) Methods: To address this gap, we conducted a comprehensive retrospective analysis of medical records spanning from 2018 to 2023, focusing on patients who underwent transsphenoidal surgery for pituitary neuroendocrine tumors (formerly called pituitary adenoma)...
April 2, 2024: Diagnostics
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REVIEW
Yuki Sato, Maria Tada, Jorg J Goronzy, Cornelia M Weyand
Giant cell arteritis (GCA) is a prototypic autoimmune disease with a highly selective tissue tropism for medium and large arteries. Extravascular GCA manifests with intense systemic inflammation and polymyalgia rheumatica; vascular GCA results in vessel wall damage and stenosis, causing tissue ischemia. Typical granulomatous infiltrates in affected arteries are composed of CD4+ T cells and hyperactivated macrophages, signifying the involvement of the innate and adaptive immune system. Lesional CD4+ T cells undergo antigen-dependent clonal expansion, but antigen-nonspecific pathways ultimately control the intensity and duration of pathogenic immunity...
April 9, 2024: Best Practice & Research. Clinical Rheumatology
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JOURNAL ARTICLE
Shibo Hou, Jingheng Chen, Ruobing Feng, Xuejiao Xu, Nan Liang, Jackson Champer
CRISPR homing gene drive is a potent technology with considerable potential for managing populations of medically and agriculturally significant insects. It induces a bias in the inheritance of the drive allele in progeny, rapidly spreading the desired gene construct throughout the population. Homing drives operate by Cas9 cleavage followed by homology-directed repair, copying the drive allele to the wild-type chromosome. However, resistance alleles formed by end-joining repair pose a significant obstacle to the spread of the drive...
April 8, 2024: Journal of Genetics and Genomics
#8
JOURNAL ARTICLE
Liangliang Wang, Fan Li, Ting Liu, Chen Ouyang, Xiaoyue Wang, Meifang Li, Zhiyu Huang, Jinhu Huang, Liping Wang, Xiaoming Wang
Campylobacter spp., such as Campylobacter jejuni and Campylobacter coli, are important zoonotic Gram-negative pathogens that cause acute intestinal diseases in humans. In this study, a retrospective analysis was conducted on previously collected Campylobacter isolates from antimicrobial resistance surveillance. A total of 29 optrA-positive C. coli strains were identified and subjected to second-generation sequencing. Multilocus sequence typing and single nucleotide polymorphism analyses demonstrated that the 29 optrA-positive isolates were genetically homogeneous...
April 4, 2024: Veterinary Microbiology
#9
JOURNAL ARTICLE
Timothy N Trotter, Andrea Wilson, Jason McBane, Carina E Dagotto, Xiao-Yi Yang, Jun-Ping Wei, Gangjun Lei, Hannah Thrash, Joshua C Snyder, Herbert Kim Lyerly, Zachary C Hartman
UNLABELLED: The ability to temporally regulate gene expression and track labeled cells makes animal models powerful biomedical tools. However, sudden expression of xenobiotic genes [e.g., GFP, luciferase (Luc), or rtTA3] can trigger inadvertent immunity that suppresses foreign protein expression or results in complete rejection of transplanted cells. Germline exposure to foreign antigens somewhat addresses these challenges; however, native fluorescence and bioluminescence abrogates the utility of reporter proteins and highly spatiotemporally restricted expression can lead to suboptimal xenoantigen tolerance...
April 9, 2024: Cancer Res Commun
#10
Muzammil Hassan, Abdul Hafeez Quereshi
It is very un comm on to discover Paraga ngliomas in the uri nar y bladder. Thes e tu mo ur s origina te from the sympathetic nerves which supp ly chromaffin cells in the bladde r wall. They can be classified as functional or nonfunctional. If functional, the most common presentations are with hypertensive crisis or post-micturition syncope. A si lent pa raganglioma of th e bl adder ca n be easily m isdiagnosed w hich can resu lt in severe pe ri- oper ative morbidity. We pre sent a ca se of a male pati ent who was being m a naged fo r hype rt ension for 2-3 ye ars...
March 2024: JPMA. the Journal of the Pakistan Medical Association
#11
JOURNAL ARTICLE
Daniel Marrero-Rodriguez, Victor A Cortes-Morales, Amayrani Cano-Zaragoza, Florencia Martinez-Mendoza, Jacobo Kerbel-Suton, Sandra Vela-Patiño, Alejandra Chavez-Santoscoy, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Erick Gomez-Apo, Guadalupe R Fajardo-Orduña, Keiko Taniguchi-Ponciano, Juan Jose Montesinos, Moises Mercado
BACKGROUND: The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells among others. MSC have been isolated from different tumors and they favor tumor cell growth, however, their role in pituitary tumors (PT) remains unknown. Herein we report the presence of MSCs in 2 ACTH-secreting PT causing Cushing disease (MCU), 2 nonfunctioning adenomas of gonadotrope differentiation (MNF) and 2 non tumoral pituitary glands (MS). METHODS: We have analyzed their transcriptomic profiles by RNAseq and compared MSC in terms of their immunosuppressive effects against lymphoid T cell and macrophage populations by means of co-cultures and flow cytometry...
April 9, 2024: Journal of Clinical Endocrinology and Metabolism
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JOURNAL ARTICLE
Scott Ferguson, Ashley Jones, Kevin Murray, Rose Andrew, Benjamin Schwessinger, Justin O Borevitz
Genomes have a highly organized architecture (nonrandom organization of functional and nonfunctional genetic elements within chromosomes) that is essential for many biological functions, particularly, gene expression and reproduction. Despite the need to conserve genome architecture, a high level of structural variation has been observed within species. As species separate and diverge, genome architecture also diverges, becoming increasingly poorly conserved as divergence time increases. However, within plant genomes, the processes of genome architecture divergence are not well described...
April 8, 2024: Genome Research
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JOURNAL ARTICLE
Peinan Sun, Huanran Yuan, Jiangpeng Pan, Zhihao Wu, Weibo Li, Xin Wang, Hanhui Kuang, Jiongjiong Chen
The loss of spines is one of the most important domestication traits for lettuce (Lactuca sativa). However, the genetics and regulation of spine development in lettuce remain unclear. We examined the genetics of spines in lettuce using a segregating population derived from a cross between cultivated and wild lettuce (Lactuca serriola). A gene encoding WUSCHEL-related homeobox transcription factor, named as WOX-SPINE1 (WS1), was identified as the candidate gene controlling the spine development in lettuce, and its function on spines was verified...
April 8, 2024: New Phytologist
#14
JOURNAL ARTICLE
Ramsey Ugarte, Christian de Virgilio, Maria Valadez, Chaiss Ugarte, Ashkan Moazzez, Mark Archie
OBJECTIVES: Some studies suggest that regional (RA) provides better patency for arteriovenous fistula (AVF) for hemodialysis (HD) access as compared to Local (LA) and General Anesthesia (GA). This study evaluates the impact of anesthetic modality on long term fistula function at 12 months. METHODS: A retrospective review of patients undergoing cephalic vein-based HD access in consecutive cases between 2014 and 2019 was conducted from five safety net hospitals. The primary endpoint was functional patency at 12 months...
April 2, 2024: Journal of Vascular Surgery
#15
JOURNAL ARTICLE
US Liver Transplant Outcomes After Normothermic Regional Perfusion vs Standard Super Rapid Recovery.
Aleah L Brubaker, Marty T Sellers, Peter L Abt, Kristopher P Croome, Shaheed Merani, Anji Wall, Phillipe Abreu, Musab Alebrahim, Roy Baskin, Humberto Bohorquez, Robert M Cannon, Kelly Cederquist, John Edwards, Benjamin G Huerter, Mark J Hobeika, Lori Kautzman, Alan N Langnas, David D Lee, Joao Manzi, Ahmed Nassar, Nikole Neidlinger, Trevor L Nydam, Gabriel T Schnickel, Farjad Siddiqui, Ashley Suah, Raeda Taj, C Burcin Taner, Giuliano Testa, Rodrigo Vianna, Frederick Vyas, Martin I Montenovo
IMPORTANCE: Normothermic regional perfusion (NRP) is an emerging recovery modality for transplantable allografts from controlled donation after circulatory death (cDCD) donors. In the US, only 11.4% of liver recipients who are transplanted from a deceased donor receive a cDCD liver. NRP has the potential to safely expand the US donor pool with improved transplant outcomes as compared with standard super rapid recovery (SRR). OBJECTIVE: To assess outcomes of US liver transplants using controlled donation after circulatory death livers recovered with normothermic regional perfusion vs standard super rapid recovery...
April 3, 2024: JAMA Surgery
#16
JOURNAL ARTICLE
Ying-Ao Liu, Yuanhao Liu, Jiajuan Tu, Yihong Shi, Junyi Pang, Qi Huang, Xun Wang, Zhixiang Lin, Yupei Zhao, Wenze Wang, Junya Peng, Wenming Wu
The diagnosis of solid pseudopapillary neoplasm of the pancreas (SPN) can be challenging due to potential confusion with other pancreatic neoplasms, particularly pancreatic neuroendocrine tumors (NETs), using current pathological diagnostic markers. We conducted a comprehensive analysis of bulk RNA sequencing data from SPNs, NETs, and normal pancreas, followed by experimental validation. This analysis revealed an increased accumulation of peroxisomes in SPNs. Moreover, we observed significant upregulation of the peroxisome marker ABCD1 in both primary and metastatic SPN samples compared with normal pancreas and NETs...
April 3, 2024: American Journal of Surgical Pathology
#17
JOURNAL ARTICLE
Guanhua Chen, Li Liu, Chunlu Tan, Qingquan Tan, Yonghua Chen, Xiangrong An, Xubao Liu, Xing Wang
PURPOSE: The purpose of our study was to investigate the clinical significance and prognostic role of the systemic immune-inflammation index (SII) in patients who underwent surgical resection for nonfunctioning pancreatic neuroendocrine tumors (pNETs). METHODS: We conducted a retrospective analysis of 364 patients with nonfunctioning pNETs. The association between the SII level and clinical parameters was investigated. The receiver operating characteristic (ROC) curve was used to calculate the optimal SII value...
April 2024: Cancer Medicine
#18
REVIEW
Harshal Shah, Avi Slavin, Julia Botvinov, Geoffrey R O'Malley, Syed Sarwar, Nitesh V Patel
INTRODUCTION: Enhanced Recovery After Surgery (ERAS) is a perioperative model of care aimed at optimizing postoperative rehabilitation and reducing hospital length of stay (LOS). Decreasing LOS avoids hospital-acquired complications, reduces cost of care, and improves patient satisfaction. Given the lack of ERAS protocols for EETS resection of pituitary adenomas, a systematic review of EETS was performed to compile patient outcomes and analyze factors that may lead to increased LOS, reoperation, and readmission rates with the intention to contribute to the development of a successful ERAS protocol for EETS...
March 27, 2024: World Neurosurgery
#19
JOURNAL ARTICLE
Elshaimaa M Mohamed, Mohamad Gamal Nada, Yasmin Ibrahim Libda, Mona Mohammed Refaat
PURPOSE: Haemodialysis provides various options for vascular access, including native arteriovenous fistulas (AVFs), arteriovenous grafts (AVGs), and central intravenous catheters. However, the use of catheters should be avoided due to their association with greater risks when opposed to AVFs or AVGs. AVFs have garnered strong endorsement as the favoured vascular access choice for extended haemodialysis. MATERIAL AND METHODS: A total of 200 patients initially diagnosed with AVF/AVG dysfunction were referred to the radiology department across 3 different institutions...
2024: Polish Journal of Radiology
#20
JOURNAL ARTICLE
Carolin M Schröter, Lukas D Bangert, Hans G Börner
Segmented block copolymers with adhesive functionality bridges in between are synthesized through the combination of controlled radical polymerization (CRP) and thiol-quinone Michael-polyaddition. CRP provides a set of α,ω-dithiol polystyrenes (PS), which react as telechelics with a low molecular weight bisquinone, resulting in thiol-catechol connectivities (TCCs). By introducing as little as 3 mol % of TCC functionalities, the bonding of the polymer on dry and wet aluminum surfaces is significantly improved while keeping the integrity of the PS segments undisturbed to constitute favorable bulk properties...
March 28, 2024: ACS Macro Letters
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