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https://www.readbyqxmd.com/read/29773782/diagnosis-incidence-predictors-and-management-of-postreperfusion-syndrome-in-pediatric-deceased-donor-liver-transplantation-a-single-center-study
#1
Liang Zhang, Ming Tian, Fushan Xue, Zhijun Zhu
BACKGROUND Postreperfusion syndrome (PRS) is a dreadful and well-documented complication in adult liver transplantation (LT). However, information regarding PRS in pediatric LT is still scarce. We aimed to identify the incidence, risk factors and associated outcomes of pediatric LT in a single-center study. MATERIAL AND METHODS The medical records of 75 consecutive pediatric patients who underwent deceased donor liver transplantation (DDLT) from July 2015 to October 2017 were retrospectively reviewed. PRS was determined according to the Peking criteria when significant arrhythmia or refractory hypotension occurred following revascularization of the liver graft...
May 18, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29767762/surgical-outcomes-following-repeat-transsphenoidal-surgery-for-nonfunctional-pituitary-adenomas-a-retrospective-comparative-study
#2
Joshua Bakhsheshian, Sarah Wheeler, Ben A Strickland, Martin H Pham, Robert C Rennert, John Carmichael, Martin Weiss, Gabriel Zada
BACKGROUND: Endonasal transsphenoidal surgery (ETSS) remains the preferred treatment for recurrent or residual nonfunctional pituitary adenomas (NFPAs). However, surgical complications and outcomes with repeat ETSS are unclear. OBJECTIVE: To compare outcomes from primary and repeat ETSS in patients with NFPAs. METHODS: Retrospective review of ETSS for NFPAs at USC University Hospital and LAC + USC Medical Center between 2000 and 2015. Patients with ≥3-mo follow-up data were included...
May 15, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29767554/a-new-resistance-gene-in-combination-with-rmg8-confers-strong-resistance-against-triticum-isolates-of-pyricularia-oryzae-in-a-common-wheat-landrace
#3
Shizhen Wang, Soichiro Asuke, Trinh Thi Phuong Vy, Yoshihiro Inoue, Izumi Chuma, Joe Win, Kenji Kato, Yukio Tosa
The wheat blast fungus (Triticum pathotype of Pyricularia oryzae) first arose in Brazil in 1985 and has recently spread to Asia. Resistance genes against this new pathogen are very rare in common wheat populations. We screened 520 local landraces of common wheat collected worldwide with Br48, a Triticum isolate collected in Brazil, and found a highly resistant, unique accession, GR119. When F2 seedlings derived from a cross between GR119 and Chinese Spring (CS, susceptible control) were inoculated with Br48, resistant and susceptible seedlings segregated in a 15:1 ratio, suggesting that GR119 carries two resistance genes...
May 16, 2018: Phytopathology
https://www.readbyqxmd.com/read/29754447/gain-of-function-mutations-in-beet-doda2-identify-key-residues-for-betalain-pigment-evolution
#4
Alexander Bean, Rasika Sunnadeniya, Neda Akhavan, Annabelle Campbell, Matthew Brown, Alan Lloyd
The key enzymatic step in betalain biosynthesis involves conversion of l-3,4-dihydroxyphenylalanine (l-DOPA) to betalamic acid. One class of enzymes capable of this is 3,4-dihydroxyphenylalanine 4,5-dioxygenase (DODA). In betalain-producing species, multiple paralogs of this gene are maintained. This study demonstrates which paralogs function in the betalain pathway and determines the residue changes required to evolve a betalain-nonfunctional DODA into a betalain-functional DODA. Functionalities of two pairs of DODAs were tested by expression in beets, Arabidopsis and yeast, and gene silencing was performed by virus-induced gene silencing...
May 13, 2018: New Phytologist
https://www.readbyqxmd.com/read/29749938/impact-of-abandoned-leads-on-cardiovascular-implantable-electronic-device-infections-a-propensity-matched-analysis-of-medic-multicenter-electrophysiologic-device-infection-cohort
#5
Thomas A Boyle, Daniel Z Uslan, Jordan M Prutkin, Arnold J Greenspon, Larry M Baddour, Stephan B Danik, Jose M Tolosana, Katherine Le, Jose M Miro, James E Peacock, Muhammad R Sohail, Holenarasipur R Vikram, Roger G Carrillo
OBJECTIVES: This study sought to evaluate the impact of abandoned cardiovascular implantable electronic device (CIED) leads on the presentation and management of device-related infections. BACKGROUND: Device infection is a serious consequence of CIEDs and necessitates removal of all hardware for attempted cure. The merits of extracting or retaining presumed sterile but nonfunctioning leads is a subject of ongoing debate. METHODS: The MEDIC (Multicenter Electrophysiologic Device Infection Cohort) prospectively enrolled patients with CIED infections at 10 institutions in the United States and abroad between January 1, 2009, and December 31, 2012...
February 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29749672/transgenic-mice-that-accept-luciferase-or-gfp-expressing-syngeneic-tumor-cells-at-high-efficiencies
#6
Naoki Aoyama, Hiroyuki Miyoshi, Hitoshi Miyachi, Masahiro Sonoshita, Masaru Okabe, Makoto Mark Taketo
Jellyfish green fluorescent protein (GFP) and firefly luciferase can serve as versatile tracking markers for identification and quantification of transplanted cancer cells in vivo. However, immune reactions against these markers can hamper the formation of syngraft tumors and metastasis that follows. Here, we report two transgenic (Tg) mouse lines that express nonfunctional mutant marker proteins, namely modified firefly luciferase (Luc2) or enhanced GFP (EGFP). These mice, named as Tg-mLuc2 and Tg-mEGFP, turned out to be immunologically tolerant to the respective tracking markers and thus efficiently accepted syngeneic cancer cells expressing the active forms of the markers...
May 11, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29749133/characteristics-of-adrenal-incidentalomas-in-a-large-prospective-computed-tomography-based-multicenter-study-the-coar-study-in-korea
#7
Seong Hee Ahn, Jae Hyeon Kim, Seung Hee Baek, Hyeonmok Kim, Yoon Young Cho, Sunghwan Suh, Beom Jun Kim, Seongbin Hong, Jung Min Koh, Seung Hun Lee, Kee Ho Song
PURPOSE: Previous studies on adrenal incidentalomas (AIs) are limited by their retrospective design, small numbers of patients, Western populations, or use of an outdated imaging technique. We investigated the characteristics of AIs in Korean patients and compared them with those reported in the largest retrospective study in Italy to discover the effects of improved imaging techniques and ethnicity differences. MATERIALS AND METHODS: This was a prospective, multicenter, cross-sectional observational study including 1005 Korean patients...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29744127/virilization-of-a-postmenopausal-woman-by-a-mucinous-cystoadenoma
#8
Sara Alonso Díaz, Belén Vega Piñero, Lía Nattero Chávez, Ignacio Pinilla Pagnon, Andrés Ortiz-Flores, Manuel Luque-Ramírez
Objective: To describe the case of the most hyperandrogenaemic ovarian mucinous cystadenoma reported to date. Methods: We present the clinical, laboratory and radiologic findings in a patient with an unusual diagnosis according to age and the clinical behaviour of the tumour, as well as a review of relevant literature. Results: A 77-year-old women came to our consult because of fronto-parietal alopecia and an augmentation of the abdominal perimeter since 1 year ago...
January 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29739797/epigenetic-regulation-of-aldosterone-synthase-gene-by-sodium-and-angiotensin-ii
#9
Yoshimichi Takeda, Masashi Demura, Fen Wang, Shigehiro Karashima, Takashi Yoneda, Mitsuhiro Kometani, Atsushi Hashimoto, Daisuke Aono, Shin-Ichi Horike, Makiko Meguro-Horike, Masakazu Yamagishi, Yoshiyu Takeda
BACKGROUND: DNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all methylation patterns are not stable. We demonstrate that stimulatory signals can change the DNA methylation status around transcription factor binding sites and a transcription start site and activate expression of the aldosterone synthase gene ( CYP11B2 ). METHODS AND RESULTS: DNA methylation of CYP11B2 was analyzed in aldosterone-producing adenomas, nonfunctioning adrenal adenomas, and adrenal glands and compared with the gene expression levels...
May 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29739724/nonfunctioning-pituitary-adenomas-in-elderly-patients
#10
REVIEW
Yasuyuki Kinoshita, Kaoru Kurisu, Kazunori Arita
BACKGROUND: Recently, several reports have revealed new aspects regarding transsphenoidal surgery (TSS) for pituitary lesions in elderly patients. OBJECTIVE: The aim of present study is to provide an updated review of the recent literature, which we hope will contribute to the management of nonfunctioning pituitary adenoma (NFPA) in elderly patients. METHODS: We searched PubMed and Web of Science for reports on TSS for NFPAs in elderly patients and reviewed the literature...
May 5, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29732572/two-novel-rhd-alleles-encoding-truncated-nonfunctional-d-polypeptides
#11
Antonella Matteocci, Tommaso Mancuso, Federica Pirelli, Tiruneh Hailemariam, Alessandra Moscetti, Katiuscia Castagna, Angela Collaretti, Letizia Rogai, Guido Nespoli, Paola Grammatico, Luca Pierelli
No abstract text is available yet for this article.
May 6, 2018: Transfusion
https://www.readbyqxmd.com/read/29731074/postoperative-doppler-ultrasonography-in-liver-transplantation
#12
Y K Chung, H J Choi, G H Na, Y K You, I Y Park
BACKGROUND: Doppler ultrasonography plays an important role in the postoperative management of liver transplantation. We present our initial experiences evaluating liver transplants with the use of postoperative Doppler sonography. METHODS: In our hospital, we performed 20 liver transplantations from July 2014 to October 2016. Among 20 patients, we performed 15 deceased-donor liver transplantations (DDLTs) and 5 living-donor liver transplantations (LDLTs). For deceased donors, inferior vena cava anastomoses were performed with the use of the piggyback technique, and for living donors, modified right grafts were used with middle hepatic vein reconstruction by Dacron graft...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29727904/endoscopic-ultrasound-guided-radiofrequency-ablation-for-management-of-benign-solid-pancreatic-tumors
#13
Jun-Ho Choi, Dong-Wan Seo, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Sung Koo Lee, Myung-Hwan Kim
BACKGROUND:  Radiofrequency ablation (RFA) has been increasingly employed in experimental and clinical settings for the management of pancreatic lesions. This study aimed to assess the safety and efficacy of endoscopic ultrasound (EUS)-guided RFA for benign solid pancreatic tumors. METHODS:  In a single-center, prospective study, 10 patients with benign solid pancreatic tumors underwent EUS-RFA. After the RFA electrode had been inserted into the pancreatic mass, the radiofrequency generator was activated to deliver 50 W of ablation power...
May 4, 2018: Endoscopy
https://www.readbyqxmd.com/read/29725066/isothermal-folding-of-a-light-up-bio-orthogonal-rna-origami-nanoribbon
#14
Emanuela Torelli, Jerzy Wieslaw Kozyra, Jing-Ying Gu, Ulrich Stimming, Luca Piantanida, Kislon Voïtchovsky, Natalio Krasnogor
RNA presents intringuing roles in many cellular processes and its versatility underpins many different applications in synthetic biology. Nonetheless, RNA origami as a method for nanofabrication is not yet fully explored and the majority of RNA nanostructures are based on natural pre-folded RNA. Here we describe a biologically inert and uniquely addressable RNA origami scaffold that self-assembles into a nanoribbon by seven staple strands. An algorithm is applied to generate a synthetic De Bruijn scaffold sequence that is characterized by the lack of biologically active sites and repetitions larger than a predetermined design parameter...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29724562/impact-of-crestal-bone-resorption-on-quality-of-life-and-professional-maintenance-with-conventional-dentures-or-locator-retained-mandibular-implant-overdentures
#15
Carine Matthys, Stijn Vervaeke, Wolfgang Jacquet, Hugo De Bruyn
STATEMENT OF PROBLEM: The influence of the mandibular resorption profile on clinical outcome after converting a conventional complete denture into a Locator-retained implant overdenture is unknown. PURPOSE: The purpose of this prospective study was to assess the oral health-related quality of life (OHRQoL) and prosthetic maintenance of mandibular overdentures on 2 Locator abutments in relation to the resorption degree of the edentulous mandible. MATERIAL AND METHODS: Twenty-five participants were treated and classified according to the Cawood and Howell (CAW-H) resorption classification for the resorption profile of the mandible, CAW-H group III-IV (n=14) and CAW-H group V (n=11)...
April 30, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29722133/pediatric-en-bloc-kidney-transplantation-from-very-small-%C3%A2-10-kg-donation-after-circulatory-death-versus-brain-death-donors-single-center-matched-pair-analysis-of-130-transplants
#16
Christoph Troppmann, Chandrasekar Santhanakrishnan, Ghaneh Fananapazir, Kathrin Troppmann, Richard Perez
En bloc kidney transplants (EBK) from very small pediatric donation after circulatory death (DCD) donors are infrequent owing to the perception that DCD adversely impacts outcomes. We retrospectively studied 130 EBKs from donors ≤10 kg (65 consecutive DCD vs. 65 donation after brain death [DBD] transplants; pair-matched for: donor weight and terminal creatinine; preservation time). For DCD vs. DBD, median donor weight was 5.0 vs. 5.0 kg; median recipient age 57 vs. 48 years (p=0.006). Graft losses from thrombosis (DCD, 5%; DBD, 7%) or primary nonfunction (DCD, 3%; DBD, 0%) were similar in both groups (p=0...
May 2, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29721547/evaluation-of-the-pharyngeal-airway-using-computational-fluid-dynamics-in-patients-with-acromegaly
#17
Keika Mukaihara, Maiko Hasegawa-Moriyama, Tomonori Iwasaki, Youichi Yamasaki, Yuichi Kanmura
Objectives: Perioperative airway management may be particularly challenging in patients with acromegaly undergoing trans-sphenoidal pituitary surgery (TSS). Management for airway obstruction is required prior to pituitary surgery to minimize perioperative hypoxia. The purpose of this retrospective study was to evaluate airway obstruction by simulation of computational fluid dynamics (CFD) using computed tomography (CT) images in patients who had undergone TSS. Methods: CT images of the nasopharyngeal airways of patients with acromegaly (n = 5) or nonfunctional pituitary adenoma (n = 6) undergoing TSS from April 2012 to January 2017 were used to construct these airways in three dimensions...
April 2018: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29721355/pituitary-fossa-chondrosarcoma-an-unusual-cause-of-a-sellar-suprasellar-mass-masquerading-as-pituitary-adenoma
#18
Gautam Dutta, Daljit Singh, Hukum Singh, Arvind Kumar Srivastava, Anita Jagetia, Deepashu Sachdeva
Background: Chondrosarcoma is a mesenchymal malignant tumor composed of tumor cells producing cartilage. It is more commonly found in older age group and usually affects the axial skeleton. Intracranial chondrosarcoma is extremely rare, and chondrosarcoma arising from the sellar region are even rarer with only a few cases described in the literature. We report a case of chondrosarcoma mimicking a sellar suprasellar mass with parasellar extension. Case Description: A 22-year old male presented with generalized intermittent headache along with diplopia and diminished visual acuity without any history of sexual dysfunction or galactorrhea...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29719333/can-preoperative-clinicoradiological-parameters-predict-the-difficulty-during-laparoscopic-retroperitoneal-simple-nephrectomy-a-prospective-study
#19
Sumit Gahlawat, Rajeev Sood, Umesh Sharma, Nikhil Khattar, Arif Akhtar, Praveen Kumar Pandey, Akhila Prasad, Swati Jain
Introduction: Urologists tend to prefer retroperitoneal approach for open nephrectomy and transperitoneal route for laparoscopic nephrectomy. Urologists consider retroperitoneal laparoscopic approach difficult to learn and perform. There is a need to objectively define predictors of difficulty during laparoscopic retroperitoneal simple nephrectomy (LRSN) for the proper preoperative selection. To the best of our knowledge, this is the first study to prospectively assess the factors associated with difficulty during LRSN...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29719132/abdominal-subcutaneous-fat-a-favorable-or-nonfunctional-fat-depot-for-glucose-metabolism-in-chinese-adults
#20
Xuhong Hou, Peizhu Chen, Gang Hu, Li Wei, Lei Jiao, Hongmei Wang, Yebei Liang, Yuqian Bao, Weiping Jia
OBJECTIVE: The objective of this study was to assess the associations of abdominal visceral and subcutaneous adipose tissue with blood glucose and beta-cell function. METHODS: In this study, 11,223 participants without known diabetes were selected for this cross-sectional analysis. Visceral and subcutaneous fat area (VFA and SFA) were measured by magnetic resonance imaging. An oral glucose tolerance test was conducted, and beta-cell function was evaluated. RESULTS: Men had significantly larger VFA but smaller SFA than women...
May 2, 2018: Obesity
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