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https://www.readbyqxmd.com/read/28886433/sudden-death-in-a-child-caused-by-a-giant-cavernous-hemangioma-of-the-anterior-mediastinum
#1
Yui Igari, Shirushi Takahashi, Akihito Usui, Yusuke Kawasumi, Masato Funayama
A 4-year-old girl who had been treated for asthma since the age of 2 years had a severe coughing fit and died suddenly. The patient had a history of occasional severe coughing fits, and these fits had been worsening in severity during the week before her death. Prior to death, she was taken to a clinician, and thymic hypertrophy was suspected based on chest X-ray findings. The clinician recommended that she visit a general hospital at a later date; however, she died that night. Postmortem radiology and autopsy revealed a large mass in the anterior mediastinum compressing the heart and airway, and no other findings attributable to sudden death were observed...
August 24, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28879635/ectopic-hamartomatous-thymoma-a-review-of-the-literature-with-report-of-new-cases-and-proposal-of-a-new-name-biphenotypic-branchioma
#2
Kimiya Sato, Lester D R Thompson, Kosuke Miyai, Takako Kono, Hitoshi Tsuda
Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm of the lower neck suggesting branchial origin. Despite use of the term thymoma in the nomenclature, there is no evidence of thymic origin or differentiation. It affects middle-aged adults with a remarkable male predominance. To date less than 80 cases have been reported in the English literature. We present here two additional cases of EHT. The first is a benign case in a 31-year-old man, showing typical histological features. The second is a malignant case in a 70-year-old woman, showing intraductal carcinoma arising in intimate association with an EHT...
September 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28872098/is-a-diagnostic-video-assisted-thoracoscopic-thymectomy-an-acceptable-first-line-approach-to-the-suspicious-anterior-mediastinal-mass
#3
Ricky Vaja, Vijay Joshi, Alan G Dawson, David A Waller
INTRODUCTION: The incidental early-stage thymic mass presents a diagnostic challenge. Video-assisted thoracoscopic (VAT) thymectomy is an attractive but potentially morbid solution. The aim was to show it can be safely applied as a first-line modality in those with undiagnosed thymic enlargement with acceptable long-term results. METHODS: A total of 45 patients were identified (24 male, median age 52 interquartile range [IQR]: 41-66 years) in a 14-year experience who had CT evidence of an enlarged, possibly malignant thymic mass, but no tissue diagnosis before undertaking VAT thymectomy...
October 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28840135/assessment-of-mediastinal-tumors-using-suvmax-and-volumetric-parameters-on-fdg-pet-ct
#4
Takahiro Morita, Mitsuaki Tatsumi, Mana Ishibashi, Kayako Isohashi, Hiroki Kato, Osamu Honda, Eku Shimosegawa, Noriyuki Tomiyama, Jun Hatazawa
OBJECTIVES: This study aimed to evaluate the role of pretreatment SUVmax and volumetric FDG positron emission tomography (PET) parameters in the differentiation between benign and malignant mediastinal tumors. In addition, we investigated whether pretreatment SUVmax and volumetric FDG-PET parameters could distinguish thymomas from thymic carcinomas, and low-risk from high-risk thymomas. METHODS: This study was conducted on 52 patients with mediastinal tumors undergoing FDG-PET/CT...
2017: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/28838625/-which-surgery-for-mediastinum-tumor-experience-of-the-department-of-thoracic-surgery-of-chu-hassan-ii-of-f%C3%A3-s
#5
S Rabiou, M Lakranbi, T Ghizlane, H Elfatemi, M Serraj, Y Ouadnouni, M Smahi
INTRODUCTION: Tumors of the mediastinum are a heterogeneous group of dysembryoplatic and neoplastic diseases essentially with different prognoses and therapeutic. These tumors develop slowly and remain long asymptomatic in 40-50% of cases. The purpose of our work is to bring the result of surgical management in diagnostic and therapeutic of principal mediastinum tumors framework. PATIENTS AND METHOD: We reviewed retrospectively the records of 68 patients in our training, between January 2009 and December 2013, for tumor of the mediastinum in the diagnostic framework and or therapy...
August 21, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/28729377/abundant-dystrophic-calcifications-mimicking-aortic-valve-abscess-in-a-patient-undergoing-elective-aortic-valve-replacement
#6
Adam L Booth, Christine Q Li, Ghannam Ayed Al-Dossari, Heather L Stevenson
Dystrophic calcifications of the aortic valve may cause symptomatic aortic stenosis and account for a significant portion of patients who undergo elective valve replacement. Calcifications appearing grossly as a cloudy fluid surrounding the aortic valve leaflets are an uncommon finding. Normally, calcified aortic valves are characterised by large, nodular masses within the aortic cusps. We report a case of dystrophic calcifications on a stenotic aortic valve encountered intraoperatively, which was suggestive of infective endocarditis and abscess formation...
July 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28689684/-ectopic-thymus-a-rare-cause-of-neck-mass-in-children
#7
S Kallel, M Mnejja, M Kessentini, A Ben Said, I Charfeddine, B Hammami, A Ghorbel
INTRODUCTION: Ectopic cervical thymus (ECT) is a rare embryological abnormality in children. It can be revealed by a compressive neck mass mistaken for a malignant tumor. Through a new case of ECT, we review the embryopathogenesis, diagnostic difficulties and therapeutic features. CLINICAL OBSERVATION: A 19-month-old girl presented a right cervical mass that quickly increased in size, causing intermittent dyspnea. The physical examination objectified a 6-cm, soft and compressible, painless right cervical tumefaction, extending from the mastoid area to the ipsilateral supraclavicular fossa...
July 6, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28680641/concurrent-intrathyroidal-thymus-and-parathyroid-in-a-patient-with-papillary-thyroid-carcinoma-a-challenging-diagnosis
#8
Georgios Velimezis, Argyrios Ioannidis, Sotirios Apostolakis, Maria Chorti, Charalampos Avramidis, Evripidis Papachristou
During embryogenesis, the thymus and inferior parathyroid glands develop from the third pharyngeal pouch and migrate to their definite position. During this process, several anatomic variations may arise, with the thyroid being one of the most common sites of ectopic implantation for both organs. Here, we report the case of a young female patient, who underwent total thyroidectomy for papillary carcinoma of the thyroid. The patient's history was remarkable for disorders of the genitourinary system. Histologic examination revealed the presence of well-differentiated intrathyroidal thymic tissue, containing an inferior parathyroid gland...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28578595/thymic-hyperplasia-associated-with-graves-disease-pathophysiology-and-proposed-management-algorithm
#9
Uzma Haider, Patrick Richards, Andrew G Gianoukakis
BACKGROUND: The association between Graves' disease (GD) and thymic hyperplasia (TH) was first described in 1912 and has been reported numerous times thereafter. TH associated with GD presents as an incidental mediastinal mass on chest X-ray or computed tomography (CT). The pathogenesis of TH in the setting of GD is unclear but seems to involve a complex interplay of hormonal and immunological mechanisms. SUMMARY: Here, the effect that thyroid hormones and autoimmunity have on thymic growth and size is reviewed...
August 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28538410/extrapleural-solitary-fibrous-tumor-in-thymic-area-a-case-report
#10
Eun Kyung Jung, Young Yoon Kim, Dong Hoon Lee, Kyung Hwa Lee, Joon Kyoo Lee
RATIONALE: Solitary fibrous tumor (SFT) is a rare benign soft tissue mesenchymal neoplasm. There have been a few reports of extrapleural SFTs although it can occur anywhere in the body. PATIENT CONCERNS: A 30-year-old male presented with an anterior neck mass since one month. DIAGNOSES: Based on physical and radiologic examination, preliminary differential diagnosis was thymic neoplasm or intrathoracic goiter. INTERVENTIONS: We performed surgical excision of the neck mass...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28429039/-true-thymic-hyperplasia-differential-diagnosis-of-thymic-mass-lesions-in-neonates-and-children
#11
C-A Weis, B Märkl, T Schuster, K Vollert, P Ströbel, A Marx
Reactive and neoplastic thymic pathologies are the main considerations in the case of masses in the anterior and middle part of the mediastinum, while neurogenic tumors are predominant in the posterior mediastinum (which are not dealt with here). In neonates and infants, the commonest pathologies in the anterior mediastinum comprise germ cell tumors (mainly teratomas), congenital thymic cysts and true thymic hyperplasia (TTH). In toddlers, teratomas, yolk sac tumors and cysts predominate. In children over 5 years of age, lymphomas are the commonest mass lesions whereas thymomas and thymic carcinomas are rare...
July 2017: Der Pathologe
https://www.readbyqxmd.com/read/28224091/imaging-of-the-pediatric-thymus-clinicoradiologic-approach
#12
REVIEW
Smita Manchanda, Ashu S Bhalla, Manisha Jana, Arun K Gupta
The thymus is a lymphatic organ that undergoes dynamic changes with age and disease. It is important to be familiar with these physiological changes in the thymus gland to be able to identify pathology and make an accurate diagnosis. The thymus may be involved in multisystem disorders or show focal isolated lesions. The aim of this article is to review the radiological anatomy of the thymus, normal variants, and pathology including hyperplasia and benign/malignant lesions involving the thymus gland in the pediatric age group...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28147469/thymoma-and-synchronous-primary-mediastinal-seminomas-with-florid-follicular-lymphoid-hyperplasia-in-the-anterior-mediastinum-a-case-report-and-review-of-the-literature
#13
Hyang-Im Lee, In-Seok Jang, Kyung Nyeo Jeon, Gyung Hyuck Ko, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jeong-Hee Lee
Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Therefore, excluding metastasis is very important. Recently, we treated a young adult patient with multiple thymic masses that occurred simultaneously...
March 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28121481/robotic-thymectomy-learning-curve-and-associated-perioperative-outcomes
#14
Mohamed K Kamel, Mohamed Rahouma, Brendon M Stiles, Abu Nasar, Nasser K Altorki, Jeffrey L Port
INTRODUCTION: Recently, robotic-assisted thymectomy (RAT) has emerged as an alternative to either, an open transsternal approach or to a video-assisted thoracoscopic approach, for both thymic tumors and benign lesions. We have reviewed our early experience with RAT to assess the associated learning curve as well as the short-term perioperative outcomes. METHODS: A prospectively collected database was reviewed for patients who underwent RAT for all causes in the period 2012-2016...
July 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28033154/malignant-melanoma-in-association-with-a-thymic-nevus-in-a-patient-with-a-giant-congenital-nevus
#15
Yulia Shvartser-Beryozkin, Alexander Yakobson, Daniel Benharroch, Milton Saute, Meora Feinmesser
Nevi and melanocytic proliferations are known to appear in multiple extracutaneous sites, including lymph nodes and meninges. We report a case of an anterior mediastinal mass in a patient with a giant congenital nevus and neurofibromatosis type I. Histologically, the tumor was found to be a malignant melanoma in the thymus arising in association with a nevus that involved most of the thymic tissue. There was no sign of cutaneous melanoma on skin examination. We suggest that the tumor originated from the benign nevus in the thymus, a rare extracutaneous location for nevi and malignant melanoma...
December 28, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27942480/diagnostic-imaging-of-benign-and-malignant-neck-masses-in-children-a-pictorial-review
#16
REVIEW
Ruth Elizabeth Brown, Srikrishna Harave
Neck masses are frequently encountered in pediatric medicine, and can present a diagnostic dilemma for the clinicians involved. There are several means by which neck masses in children can be subdivided, for example by age at presentation, anatomical location including compartments and fascia of the neck, their classical appearance when imaged, or by etiology. When imaging children the clinicians must be mindful of radiation exposure and as such ultrasound (US) is often attempted first. Cross sectional imaging can be helpful for problem solving with CT being particularly useful for assessing the patient in more acute scenarios, for example when there is airway compromise...
October 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/27941539/primary-salivary-gland-type-tumors-of-the-thymus
#17
REVIEW
Neda Kalhor, Annikka Weissferdt, Cesar A Moran
The existence of primary salivary gland type tumors (SGTs), similar to those occurring in the major salivary glands, is well known in the thoracic cavity. When they occur in this anatomic area, these tumors more commonly arise from the lung. However, the existence of these tumors primarily affecting the thymus, although recognized in the literature, is rather not well documented or known. In addition, contrary to the primary lung SGTs, which are predominantly of the malignant type, these tumors when occur in thymus encompass a wider spectrum of biology ranging from benign to low grade, and high grade malignancy...
January 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/27116848/thyroid-hemiagenesis-from-childhood-to-adulthood-review-of-literature-and-personal-experience
#18
REVIEW
Vincenzo De Sanctis, Ashraf T Soliman, Salvatore Di Maio, Heba Elsedfy, Nada A Soliman, Rania Elalaily
Thyroid hemiagenesis (TH) is a rare congenital abnormality of the thyroid gland, characterised by the absence of one lobe. The true prevalence of this congenital abnormality is not known because the absence of one thyroid lobe usually does not cause clinical symptoms by itself. Between 1970 and 2010, 329 cases of TH have been reported. It is interesting to note that most cases have an agenesis of the left lobe (80% of cases) followed by the isthmus (44-50% of cases). Although the female to male ratio was 1:1...
March 2016: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/27097982/hsp27-and-70-expression-in-thymic-epithelial-tumors-and-benign-thymic-alterations-diagnostic-prognostic-and-physiologic-implications
#19
S Janik, A I Schiefer, C Bekos, P Hacker, T Haider, J Moser, W Klepetko, L Müllauer, H J Ankersmit, B Moser
Thymic Epithelial Tumors (TETs), the most common tumors in the anterior mediastinum in adults, show a unique association with autoimmune Myasthenia Gravis (MG) and represent a multidisciplinary diagnostic and therapeutic challenge. Neither risk factors nor established biomarkers for TETs exist. Predictive and diagnostic markers are urgently needed. Heat shock proteins (HSPs) are upregulated in several malignancies promoting tumor cell survival and metastases. We performed immunohistochemical staining of HSP27 and 70 in patients with TETs (n = 101) and patients with benign thymic alterations (n = 24)...
April 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26930331/thymoma-with-an-incidental-benign-laryngeal-mass-mimicking-laryngeal-carcinoma-case-report
#20
Gokce Simsek, Istemihan Akin, Cem Saka, Fulya Koybasioglu
Thymic carcinomas are rarely seen. Because of recurrent laryngeal nerve involvement, hoarseness is a common presenting symptom. Persistent hoarseness in a male smoker past his fifth decade is also a distinctive symptom for laryngeal carcinoma. Stroboscopic laryngeal examination and biopsy are required for the diagnosis. In this article we describe a case involving a patient with thymic carcinoma who, interestingly, also presented with a benign laryngeal mass with unilateral vocal fold fixation. We emphasize the importance of keeping in mind nonlaryngeal pathologies invading the recurrent laryngeal nerve in patients with persistent hoarseness and a nonspesific laryngeal mass...
February 2016: Ear, Nose, & Throat Journal
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