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https://www.readbyqxmd.com/read/28102694/evaluation-of-sample-extraction-methods-for-minimizing-hematocrit-effect-on-whole-blood-analysis-with-volumetric-absorptive-microsampling
#1
Zhengqi Ye, Hong Gao
AIM: Volumetric absorptive microsampler (VAMS) was designed to sample a fixed volume of blood regardless of the hematocrit (HCT) levels. Model compounds with a wide range of hydrophobicity were evaluated for their extraction recoveries from VAMS dried blood samples. RESULTS: For the highly hydrophobic compounds, recoveries with methanol or methanol/acetonitrile extraction were higher compared with using the aqueous mixture of methanol or acetonitrile. Extraction with methanol/acetonitrile (1:1) yielded more consistent recovery across the HCT range of 20-70% than using methanol alone, with good linearity, accuracy and precision achieved from 1 to 2000 ng/ml...
January 19, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28102450/hidden-blood-loss-and-the-influential-factors-after-percutaneous-kyphoplasty-surgery
#2
Yao-Sen Wu, Hui Zhang, Wen-Hao Zheng, Zhen-Hua Feng, Ze-Xin Chen, Yan Lin
PURPOSE: Percutaneous kyphoplasty (PKP) is a minimally invasive procedure for the treatment of osteoporotic vertebral compression fractures (OVCFs). It is generally considered that there is little blood loss during the surgery. However, a significant perioperative hidden blood loss (HBL) is neglected. This study was to examine the amount of HBL and determine the influential factors during PKP. METHODS: From January 2015 to January 2016, 115 patients with OVCFs who were scheduled to have a PKP were enrolled in this study...
January 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28100507/efficacy-of-iron-supplement-bars-to-reduce-anemia-in-urban-indian-women-a-cluster-randomized-controlled-trial
#3
Rajvi Mehta, Alyssa C Platt, Xizi Sun, Mukesh Desai, Dennis Clements, Elizabeth L Turner
BACKGROUND: India's high prevalence of iron-deficiency anemia has largely been attributed to the local diet consisting of nonheme iron, which has lower absorption than that of heme iron. OBJECTIVE: We assessed the efficacy of the consumption of iron-supplement bars in raising hemoglobin concentrations and hematocrit percentages in anemic (hemoglobin concentration <12 g/dL) Indian women of reproductive age. DESIGN: The Let's be Well Red study was a 90-d, pair-matched, cluster-randomized controlled trial...
January 18, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28100476/chronic-anemic-hypoxemia-attenuates-glucose-stimulated-insulin-secretion-in-fetal-sheep
#4
Joshua S Benjamin, Christine B Culpepper, Laura D Brown, Stephanie R Wesolowski, Sonnet S Jonker, Melissa Ann Davis, Sean W Limesand, Randall B Wilkening, William W Hay, Paul J Rozance
Fetal insulin secretion is inhibited by acute hypoxemia. The relationship between prolonged hypoxemia and insulin secretion, however, is less well defined. To test the hypothesis that prolonged fetal hypoxemia impairs insulin secretion, studies were performed in sheep fetuses that were bled to anemic conditions for 9 ± 0 days (anemic, n=19) and compared to control fetuses (n=15). Arterial hematocrit and oxygen content were 34% and 52% lower, respectively, in anemic vs. control fetuses (P<0.0001). Plasma glucose concentrations were 21% higher in the anemic group (P<0...
January 18, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28099709/preliminary-study-of-the-effects-of-furosemide-on-blood-pressure-during-late-onset-pre-eclampsia-in-patients-with-high%C3%A2-cardiac-output
#5
Péter Tamás, Eszter Hantosi, Bálint Farkas, Zsolt Ifi, József Betlehem, József Bódis
OBJECTIVE: To examine the effect of furosemide on hypertension and edema in patients with pre-eclampsia experiencing high cardiac output. METHODS: The present cohort study enrolled patients with pre-eclampsia who were admitted to the pregnancy pathology unit of the Department of Obstetrics and Gynecology, University of Pécs, Hungary, between January 1 and December 31, 2015. Eligible patients had singleton pregnancies with no fetal anomalies, high blood volume, visible edema, and a hematocrit concentration below 37 L/L...
January 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099399/the-association-of-serum-25-hydroxyvitamin-d-with-biomarkers-of-hemolysis-in-pediatric-patients-with-sickle-cell-disease
#6
Samuel A Adegoke, Josefina A P Braga, Adekunle D Adekile, Maria S Figueiredo
Although vitamin D deficiency (VDD) has been linked to anemia among sickle cell disease (SCD), its relationship with hemolysis is unclear. Serum 25-hydroxyvitamin D and biomarkers of hemolysis (hemoglobin [Hb]/hematocrit, reticulocyte percentage, absolute reticulocyte, and lactate dehydrogenase [LDH] levels) in 36 hydroxyurea-naive SCD children were quantified. Correlations were significantly positive with Hb/hematocrit (r=0.40, P=0.017; r=0.45, P=0.006, respectively); inverse with reticulocyte percentage, absolute reticulocyte, and LDH (r=-0...
January 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28096614/evidence-of-hemolysis-in-pigs-infected-with-highly-virulent-african-swine-fever-virus
#7
Zaven Karalyan, Hovakim Zakaryan, Elina Arakelova, Violeta Aivazyan, Marina Tatoyan, Armen Kotsinyan, Roza Izmailyan, Elena Karalova
AIM: The research was conducted to understand more profoundly the pathogenetic aspects of the acute form of the African swine fever (ASF). MATERIALS AND METHODS: A total of 10 pigs were inoculated with ASF virus (ASFV) (genotype II) in the study of the red blood cells (RBCs), blood and urine biochemistry in the dynamics of disease. RESULTS: The major hematological differences observed in ASFV infected pigs were that the mean corpuscular volume, mean corpuscular hemoglobin, and hematocrits were significantly decreased compared to controls, and the levels of erythropoietin were significantly increased...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28096432/effects-of-activity-genetic-selection-and-their-interaction-on-muscle-metabolic-capacities-and-organ-masses-in-mice
#8
Scott A Kelly, Fernando R Gomes, Erik M Kolb, Jessica L Malisch, Theodore Garland
Chronic voluntary exercise elevates total daily energy expenditure (DEE) and food consumption, potentially resulting in organ compensation supporting nutrient extraction/utilization. Additionally, species with naturally higher DEE often have larger processing organs, which may represent genetic differences and/or phenotypic plasticity. We tested for possible adaptive changes in organ masses of 4 replicate lines of house mice selected (37 generations) for high running (HR lines) compared with 4 non-selected control (C) lines...
January 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28095380/polycythemia-vera-management-and-challenges-in-the-community-health-setting
#9
Aaron T Gerds, Kim-Hien Dao
Patients with polycythemia vera (PV) experience shortened survival, increased risk of thromboembolic and hemorrhagic events, and burdensome symptoms. For all patients with PV, treatment with aspirin and hematocrit control with phlebotomy are recommended. In addition, patients with high-risk status or poor hematocrit control benefit from cytoreductive therapy with hydroxyurea, although approximately 1 in 4 patients develops resistance or intolerance. For patients who are resistant to or intolerant of hydroxyurea, studies have shown that ruxolitinib, a Janus kinase 1/2 inhibitor, provides hematocrit control, reduces spleen size, normalizes blood counts, and improves PV-related symptoms...
January 18, 2017: Oncology
https://www.readbyqxmd.com/read/28093896/intravenous-combined-with-topical-administration-of-tranexamic-acid-in-primary-total-hip-arthroplasty-a-randomized-controlled-trial
#10
Yi Zeng, Hai-Bo Si, Bin Shen, Jing Yang, Zong-Ke Zhou, Peng-de Kang, Fu-Xing Pei
OBJECTIVE: Although there are still some controversies, large previous studies have confirmed that intravenous (i.v.) tranexamic acid (TXA) can effectively reduce blood loss and transfusions in total hip arthroplasty (THA) without increasing the risk of deep venous thrombosis. However, few studies have investigated the combination of i.v. and topical application of TXA in primary THA. The purpose of our current study is to examine whether i.v. combined with topical administration of TXA decreases postoperative blood loss and transfusion rates after THA...
January 17, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28093803/novel-ecg-synchronized-pulsatile-ecls-system-with-various-heart-rates-and-cardiac-arrhythmias-an-in-vitro-study
#11
Shigang Wang, Shannon B Spencer, Allen R Kunselman, Akif Ündar
The objective of this study is to evaluate electrocardiography (ECG)-synchronized pulsatile flow under varying heart rates and different atrial and ventricular arrhythmias in a simulated extracorporeal life support (ECLS) system. The ECLS circuit consisted of an i-cor diagonal pump and console, an iLA membrane ventilator, and an 18 Fr arterial cannula. The circuit was primed with lactated Ringer's solution and packed red blood cells (hematocrit 35%). An ECG simulator was used to trigger pulsatile flow and to generate selected cardiac rhythms...
January 2017: Artificial Organs
https://www.readbyqxmd.com/read/28092618/evaluation-of-portable-blood-glucose-meters-using-canine-and-feline-pooled-blood-samples
#12
A Mori, H Oda, E Onozawa, S Shono, T Takahashi, S Yamashita, H Fujimoto, T Sako
This study evaluated the accuracy and reproducibility of a human portable blood glucose meter (PBGM) for canine and feline whole blood. Reference plasma glucose values (RPGV) were concurrently measured using glucose oxidation methods. Fifteen healthy dogs and 6 healthy cats were used for blood sampling. Blood glucose concentrations and hematocrits were adjusted using pooled blood samples for our targeted values. A positive correlation between the PBGM and RPGV was found for both dogs (y = 0.877, x = -24.38, r = 0...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28091909/modes-of-hypotensive-action-of-dihydroquercetin-in-arterial-hypertension
#13
M B Plotnikov, O I Aliev, A V Sidekhmenova, A Yu Shamanaev, A M Anishchenko, A V Nosarev, E A Pushkina
We studied the effect of dihydroquercetin (20 mg/kg/day intragastrically for 6 weeks) on mean BP and macro- and microrheological blood parameters in hypertensive SHR rats; in vitro effect of dihydroquercetin on the tone in thoracic aorta rings isolated from hypertensive SHR rats were also examined. At the end of the treatment course, the mean BP in the experimental rats decreased by 11%; the left ventricular mass index by 2%, and whole blood viscosity by 7-10% in comparison with control SHR rats; erythrocyte aggregation half-time increased by 15%; plasma viscosity, hematocrit, and erythrocyte deformability did not change...
January 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28091880/inhibition-of-neuronal-nitric-oxide-synthase-activity-does-not-alter-vasopressin-secretion-in-septic-rats
#14
Camila Henriques Coelho, Thalita Freitas Martins, Gabriela Ravanelli Oliveira-Pelegrin, Maria José Alves da Rocha
BACKGROUND/PURPOSE: During the early phase of sepsis, hypotension is accompanied by increase of plasma vasopressin hormone (AVP) levels, which decline during the late phase. This hypotension is due in part to increase of nitric oxide (NO) synthesis by nitric oxide synthase (NOS) enzyme. Neuronal isoform of this enzyme (nNOS) is present in vasopressinergics neurons of hypothalamus, but its role in vasopressin secretion during sepsis is unknown. METHODS: We evaluated the role of nNOS in NO production and vasopressin secretion during sepsis...
January 16, 2017: Pituitary
https://www.readbyqxmd.com/read/28091810/severe-lead-toxicosis-in-a-lionhead-rabbit
#15
Kristen M Walter, Karyn Bischoff, Ricardo de Matos
INTRODUCTION: Lead toxicosis occurs in veterinary patients, with few reports involving rabbits, and no previous reports using oral calcium disodium EDTA. CASE REPORT: A 7-year-old male castrated Lionhead rabbit presented to the Cornell University Hospital for Animals (CUHA) for evaluation after a 2-day history of lethargy and a 2-week history of hyporexia. The patient had been observed pulling paint from the walls of the home, a house built circa 1900, in the months prior to presentation...
January 13, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28090238/red-blood-cell-dynamics-in-biomimetic-microfluidic-networks-of-pulmonary-alveolar-capillaries
#16
Hagit Stauber, Dan Waisman, Netanel Korin, Josué Sznitman
The pulmonary capillary networks (PCNs) embody organ-specific microvasculatures, where blood vessels form dense meshes that maximize the surface area available for gas exchange in the lungs. With characteristic capillary lengths and diameters similar to the size of red blood cells (RBCs), seminal descriptions coined the term "sheet flow" nearly half a century ago to differentiate PCNs from the usual notion of Poiseuille flow in long straight tubes. Here, we revisit in true-scale experiments the original "sheet flow" model and devise for the first time biomimetic microfluidic platforms of organ-specific PCN structures perfused with RBC suspensions at near-physiological hematocrit levels...
January 10, 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28090234/increased-hematocrit-during-sodium-glucose-cotransporter-2-inhibitor-therapy
#17
Samuel N Heyman, Mogher Khamaisi, Christian Rosenberger, Auryan Szalat, Zaid Abassi
No abstract text is available yet for this article.
February 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28089084/predicting-the-need-for-intra-operative-large-volume-blood-transfusions-during-thoraco-abdominal-aortic-aneurysm-repair
#18
M Pieri, P Nardelli, M De Luca, G Landoni, S Frassoni, G Melissano, A Zangrillo, R Chiesa, F Monaco
OBJECTIVE: Thoraco-abdominal aortic aneurysm (TAAA) repair is a complex procedure performed in patients at high cardiovascular risk. High volume intra-operative bleeding is often recorded, and the amount of intra-operative blood product transfusion is associated with relevant morbidity and mortality. The aim of the study was to identify pre-operative predictors of intra-operative large volume blood transfusions (LVBT) to stratify patients pre-operatively. METHODS: This was a retrospective analysis of prospectively collected data of all patients who underwent open TAAA surgery at San Raffaele Scientific Institute from January 2009 to December 2015...
January 6, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28079789/the-impact-of-irrigating-fluid-absorption-on-blood-coagulation-in-patients-undergoing-transurethral-resection-of-the-prostate-a-prospective-observational-study-using-rotational-thromboelastometry
#19
Hyun-Jung Shin, Hyo-Seok Na, Young-Tae Jeon, Hee-Pyoung Park, Sun-Woo Nam, Jung-Won Hwang
Although endoscopic transurethral resection of the prostate (TURP) is a well-established procedure as a treatment for benign prostatic hyperplasia, its complications remain a concern. Among these, coagulopathy may be caused by the absorption of irrigating fluid. This study aimed to evaluate such phenomenon using a rotational thromboelastometry (ROTEM).A total of 20 patients undergoing TURP participated in this study. A mixture of 2.7% sorbitol-0.54% mannitol solution and 1% ethanol was used as an irrigating fluid, and fluid absorption was measured via the ethanol concentration in expired breath...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28078211/a-case-series-of-the-safety-and-efficacy-of-testosterone-replacement-therapy-in-renal-failure-and-kidney-transplant-patients
#20
Ahmad Majzoub, Daniel A Shoskes
BACKGROUND: Hypogonadism is common in patients with renal dysfunction and does not always correct following transplantation. Recent studies show increased mortality for dialysis and transplant patients with low testosterone (T). These patients are often not treated due to concerns over efficacy and complications (both real and imagined). There is surprisingly scant literature supporting the use of T therapy in these patients. We wished to examine the results of T therapy in our patients with renal failure or following transplant...
December 2016: Translational Andrology and Urology
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