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dominant frequency atrial fibrillation ablation

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https://www.readbyqxmd.com/read/28438722/propagation-of-meandering-rotors-surrounded-by-areas-of-high-dominant-frequency-in-persistent-atrial-fibrillation
#1
João Salinet, Fernando S Schlindwein, Peter Stafford, Tiago P Almeida, Xin Li, Frederique J Vanheusden, María S Guillem, G André Ng
BACKGROUND: Identification of arrhythmogenic regions remains a challenge in persistent atrial fibrillation (persAF). Frequency and phase analysis allows identification of potential ablation targets. OBJECTIVE: This study aimed to investigate the spatiotemporal association between dominant frequency (DF) and reentrant phase activation areas. METHODS: A total of 8 persAF patients undergoing first-time catheter ablation procedure were enrolled...
April 22, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28421394/waveform-integrity-in-atrial-fibrillation-the-forgotten-issue-of-cardiac-electrophysiology
#2
Miguel Martínez-Iniesta, Juan Ródenas, Raúl Alcaraz, José J Rieta
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice with an increasing prevalence of about 15% in the elderly. Despite other alternatives, catheter ablation is currently considered as the first-line therapy for the treatment of AF. This strategy relies on cardiac electrophysiology systems, which use intracardiac electrograms (EGM) as the basis to determine the cardiac structures contributing to sustain the arrhythmia. However, the noise-free acquisition of these recordings is impossible and they are often contaminated by different perturbations...
April 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28269048/an-algorithm-for-rotor-tracking-in-atrial-fibrillation-using-graph-search-based-periodic-peak-detection
#3
Rupin Dalvi, Adrian Suszko, Vijay S Chauhan
Rotors are rotating electrical waves that may sustain atrial fibrillation (AF); thereby providing therapeutic targets for catheter ablation. We propose a method for identifying rotors from circular catheter recordings of bipolar intracardiac electrograms (EGM) during AF. We use dominant frequency-based periodicity detection along with a graph search algorithm to identify the most dominant periodic activations or peaks of interest in each bipolar EGM recorded by a multipolar circular catheter. We then track the activations across catheter bipoles to determine whether they conform to the rotational pattern of a rotor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28241971/an-interactive-platform-to-guide-catheter-ablation-in-human-persistent-atrial-fibrillation-using-dominant-frequency-organization-and-phase-mapping
#4
Xin Li, João L Salinet, Tiago P Almeida, Frederique J Vanheusden, Gavin S Chu, G André Ng, Fernando S Schlindwein
BACKGROUND AND OBJECTIVE: Optimal targets for persistent atrial fibrillation (persAF) ablation are still debated. Atrial regions hosting high dominant frequency (HDF) are believed to participate in the initiation and maintenance of persAF and hence are potential targets for ablation, while rotor ablation has shown promising initial results. Currently, no commercially available system offers the capability to automatically identify both these phenomena. This paper describes an integrated 3D software platform combining the mapping of both frequency spectrum and phase from atrial electrograms (AEGs) to help guide persAF ablation in clinical cardiac electrophysiological studies...
April 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28227263/an-algorithm-for-rotor-tracking-in-atrial-fibrillation-using-graph-search-based-periodic-peak-detection
#5
Rupin Dalvi, Adrian Suszko, Vijay S Chauhan, Rupin Dalvi, Adrian Suszko, Vijay S Chauhan, Rupin Dalvi, Adrian Suszko, Vijay S Chauhan
Rotors are rotating electrical waves that may sustain atrial fibrillation (AF); thereby providing therapeutic targets for catheter ablation. We propose a method for identifying rotors from circular catheter recordings of bipolar intracardiac electrograms (EGM) during AF. We use dominant frequency-based periodicity detection along with a graph search algorithm to identify the most dominant periodic activations or peaks of interest in each bipolar EGM recorded by a multipolar circular catheter. We then track the activations across catheter bipoles to determine whether they conform to the rotational pattern of a rotor...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28217229/evaluation-of-the-characteristics-of-rotational-activation-at-high-dominant-frequency-and-complex-fractionated-atrial-electrogram-sites-during-atrial-fibrillation
#6
Koji Kumagai, Kentaro Minami, Daisuke Kutsuzawa, Shigeru Oshima
BACKGROUND: High-dominant frequency (DF) and continuous complex fractionated atrial electrogram (CFAE) sites as surrogates for localized sources maintaining atrial fibrillation (AF) are potential AF ablation targets. This study aimed to evaluate the characteristics of a rotational activation at high-DF and continuous CFAE sites in AF patients. METHODS: Thirty-two consecutive AF patients (5 paroxysmal and 27 non-paroxysmal) underwent ablation using the NavX system...
February 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28217228/spatiotemporal-characteristics-of-atrial-fibrillation-electrograms-a-novel-marker-for-arrhythmia-stability-and-termination
#7
Shivshankar Thanigaimani, Anthony G Brooks, Pawel Kuklik, Darragh J Twomey, Samantha Franklin, Erik Noschka, Darius Chapman, Rajeev K Pathak, Rajiv Mahajan, Prashanthan Sanders, Dennis H Lau
BACKGROUND: Sequentially mapped complex fractionated atrial electrograms (CFAE) and dominant frequency (DF) sites have been targeted during catheter ablation for atrial fibrillation (AF). However, these strategies have yielded variable success and have not been shown to correlate consistently with AF dynamics. Here, we evaluated whether the spatiotemporal stability of CFAE and DF may be a better marker of AF sustenance and termination. METHODS: Eighteen sheep with 12 weeks of "one-kidney, one-clip" hypertension underwent open-chest studies...
February 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27614722/termination-of-atrial-spiral-waves-by-traction-into-peripheral-non-1-1-conducting-regions-a-numerical-study
#8
Amit Rozner, Sharon Zlochiver
Atrial ablation has been recently utilized to treat atrial fibrillation (AF) by isolation or destruction of arrhythmia drivers. In chronic or persistent AF patients these drivers often consist of one or few rotors at unknown locations, and several ablations are commonly conducted before arrhythmia is terminated. However, the irreversible damage done to the tissue may lead to AF recurrence. We propose an alternative strategy to terminate rotor activity by its attraction into a non 1:1 conducting region. The feasibility of the method was numerically tested in 2D models of chronic AF human atrial tissue...
September 7, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27393959/differences-in-continuous-spectra-of-fractionated-electrograms-in-paroxysmal-versus-persistent-atrial-fibrillation
#9
Edward J Ciaccio, Angelo B Biviano, Vivek Iyer, Hasan Garan
INTRODUCTION: Quantitative measurements are helpful to discern fractionated electrograms in paroxysmal and persistent atrial fibrillation (AF), and may be useful to detect optimal ablation sites. However, electrical activation events can be transient, leading to erroneous estimates of electrogram properties. Measurement of continuous changes in electrogram frequency content may improve analysis. METHOD: Fractionated local electrograms from 10 paroxysmal and 10 persistent AF patients were acquired from outside the pulmonary vein ostia and left atrial free wall using the distal bipolar ablation catheter electrode, and analyzed over continuous 16 second intervals...
September 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27354867/efficacy-of-atrial-substrate-modification-based-on-dominant-frequency-of-paroxysmal-atrial-fibrillation
#10
Koji Kumagai, Kentaro Minami, Daisuke Kutsuzawa, Shigeru Oshima
BACKGROUND: The endpoint of ablation procedures is suggested to be non-inducibility of paroxysmal atrial fibrillation (PAF). However, the prognosis of induced AF/atrial tachycardia (AT) after pulmonary vein isolation (PVI) in PAF patients remains unclear. METHODS: A total of 122 PAF patients were divided into the following 3 groups: Group 1, 79 without AF/AT induced after PVI; Group 2, 21 with AF/AT induced or sustained after PVI, and followed by a high-dominant frequency (DF) and continuous complex fractionated atrial electrogram (CFAE) site ablation and, if necessary, linear ablation; and Group 3, 22 with external cardioversion of AF/AT induced or sustained after PVI...
June 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27226336/spectral-analysis-of-electrocardiograms-in-patients-with-inducible-atrial-fibrillation-after-catheter-ablation-predicts-sinus-rhythm-maintenance
#11
Stavros Stavrakis, John W Dyer, Benjamin J Scherlag, Zeeshan Khan, Paul Yeung, Jawad Chohan, Sunny S Po
BACKGROUND: We aimed to develop a novel predictive marker for atrial fibrillation (AF) recurrence in patients with inducible AF after catheter ablation, based on power spectral analysis of baseline and postablation electrocardiograms. METHODS: Twenty-five patients who had undergone their first AF ablation procedure (pulmonary vein isolation and ganglionated plexi ablation) and had inducible AF after ablation were included. A 30-second interval of AF was chosen for each patient before and after ablation, and a periodogram of the atrial activity was computed...
January 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/27225323/radiofrequency-ablation-of-atrial-tachyarrhythmias-in-adults-with-tetralogy-of-fallot-predictors-of-success-and-outcome
#12
Vivienne A Ezzat, Matthew J Ryan, Justin O'Leary, Cono Ariti, John Deanfield, Bejal Pandya, Shay Cullen, Fiona Walker, Fakhar Khan, Dominic J Abrams, Pier D Lambiase, Martin D Lowe
BACKGROUND: Adults with tetralogy of Fallot experience atrial tachyarrhythmias; however, there are a few data on the outcomes of radiofrequency ablation. We examined the characteristics, outcome, and predictors of recurrence of atrial tachyarrhythmias after radiofrequency ablation in tetralogy of Fallot patients. Methods/results Retrospective data were collected from 2004 to 2013. In total, 56 ablations were performed on 37 patients. We identified two matched controls per case: patients with tetralogy of Fallot but no radiofrequency ablation and not known to have atrial tachyarrhythmias...
March 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/27221509/electrocardiographic-spectral-features-for-long-term-outcome-prognosis-of-atrial-fibrillation-catheter-ablation
#13
Raúl Alcaraz, Fernando Hornero, José J Rieta
Atrial fibrillation (AF) is the most common arrhythmia in routine clinical practice. Despite many years of research, its mechanisms still are not well understood, thus reducing the effectiveness of AF treatments. Nowadays, pulmonary vein isolation by catheter ablation is the treatment of choice for AF resistant either to pharmacological or electrical cardioversion. However, given that long-term recurrences are common, an appropriate patient selection before the procedure is of paramount relevance in the improvement of AF catheter ablation outcome...
November 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27122948/intrinsic-cardiac-autonomic-ganglionated-plexi-within-epicardial-fats-modulate-the-atrial-substrate-remodeling-experiences-with-atrial-fibrillation-patients-receiving-catheter-ablation
#14
Rahul Singhal, Li-Wei Lo, Yenn-Jiang Lin Lin, Shih-Lin Chang, Yu-Feng Hu, Tze-Fan Chao, Fa-Po Chung, Cheun-Wang Chiou, Hsuan-Ming Tsao, Shih-Ann Chen
BACKGROUND: A recent study reported the close relationship between high dominant frequent (DF) sites [atrial fibrillation (AF) nest] and the intrinsic cardiac autonomic nervous system. The aim of this study was to investigate the correlation between the regional distribution of epicardial fat and the properties of the biatrial substrates in AF patients. METHODS: We studied 32 patients with paroxysmal (n = 23) and persistent (n = 9) AF. The epicardial fat volume around the left atrium (LA) was evaluated using 64-slice multidetector computed tomography and the topographic distribution of the fat volume was assessed...
March 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27093312/noninvasive-imaging-of-high-frequency-drivers-and-reconstruction-of-global-dominant-frequency-maps-in-patients-with-paroxysmal-and-persistent-atrial-fibrillation
#15
Zhaoye Zhou, Qi Jin, Lin Yee Chen, Long Yu, Liqun Wu, Bin He
OBJECTIVE: Highest dominant-frequency (DF) drivers maintaining atrial fibrillation (AF) activities are effective ablation targets for restoring sinus rhythms in patients. This study aims to investigate whether AF drivers with highest activation rate can be noninvasively localized by means of a frequency-based cardiac electrical imaging (CEI) technique, which may aid in the planning of ablation strategy and the investigation of the underlying mechanisms of AF. METHOD: A total of seven out of 13 patients were recorded with spontaneous paroxysmal or persistent AF and analyzed...
June 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/26968663/mechanisms-of-atrial-fibrillation-rotors-ionic-determinants-and-excitation-frequency
#16
REVIEW
Omer Berenfeld, José Jalife
Atrial fibrillation (AF) is the most common cardiac arrhythmia; however, therapy is suboptimal. We review recent data on dynamics of wave propagation during AF and its mechanistic link to the substrate. Data show that the dominant frequency (DF) increase during transition to persistent AF may be explained by rotor acceleration. We discuss how translation of experimentally derived understanding of the rotors may find its way into the clinic, focusing on studies analyzing spatial distribution of DF in the atria of patients with paroxysmal versus persistent AF, and how that knowledge might contribute to improve the outcome of AF ablation procedures...
April 2016: Heart Failure Clinics
https://www.readbyqxmd.com/read/26953240/three-dimensional-dominant-frequency-mapping-using-autoregressive-spectral-analysis-of-atrial-electrograms-of-patients-in-persistent-atrial-fibrillation
#17
João L Salinet, Nicholas Masca, Peter J Stafford, G André Ng, Fernando S Schlindwein
BACKGROUND: Areas with high frequency activity within the atrium are thought to be 'drivers' of the rhythm in patients with atrial fibrillation (AF) and ablation of these areas seems to be an effective therapy in eliminating DF gradient and restoring sinus rhythm. Clinical groups have applied the traditional FFT-based approach to generate the three-dimensional dominant frequency (3D DF) maps during electrophysiology (EP) procedures but literature is restricted on using alternative spectral estimation techniques that can have a better frequency resolution that FFT-based spectral estimation...
March 8, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/26909492/electrophysiological-rotor-ablation-in-in-silico-modeling-of-atrial-fibrillation-comparisons-with-dominant-frequency-shannon-entropy-and-phase-singularity
#18
Minki Hwang, Jun-Seop Song, Young-Seon Lee, Changyong Li, Eun Bo Shim, Hui-Nam Pak
BACKGROUND: Although rotors have been considered among the drivers of atrial fibrillation (AF), the rotor definition is inconsistent. We evaluated the nature of rotors in 2D and 3D in- silico models of persistent AF (PeAF) by analyzing phase singularity (PS), dominant frequency (DF), Shannon entropy (ShEn), and complex fractionated atrial electrogram cycle length (CFAE-CL) and their ablation. METHODS: Mother rotor was spatiotemporally defined as stationary reentries with a meandering tip remaining within half the wavelength and lasting longer than 5 s...
2016: PloS One
https://www.readbyqxmd.com/read/26874703/ablation-for-persistent-atrial-fibrillation-is-there-a-role-for-more-than-pvi
#19
Jason M Lappe, Michael J Cutler, John D Day, T Jared Bunch
Persistent atrial fibrillation (AF) is a prevalent condition that can be difficult to treat medically, and an ablation strategy is often sought. Currently, the cornerstone of AF ablation strategies is pulmonary vein isolation (PVI). Unfortunately, the single procedure success rates are limited, particularly when long-term outcomes (>1 year) are considered. As a result, the most recent consensus statement recommends that in patients with persistent AF a more extensive ablation be considered. Many additive procedural approaches to PVI have been investigated...
March 2016: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/26850022/identification-of-dominant-excitation-patterns-and-sources-of-atrial-fibrillation-by-causality-analysis
#20
Miguel Rodrigo, Andreu M Climent, Alejandro Liberos, David Calvo, Francisco Fernández-Avilés, Omer Berenfeld, Felipe Atienza, Maria S Guillem
Burden of atrial fibrillation (AF) can be reduced by ablation of sources of electrical impulses driving AF but driver identification is still challenging. This study presents a new methodology based on causality analysis that allows identifying the hierarchically dominant areas driving AF. Identification of dominant propagation patterns was achieved by computing causal relations between intracardiac multi-electrode catheter recordings of four paroxysmal AF patients during sinus rhythm, pacing and AF. In addition, realistic mathematical models of the atria during AF were used to validate the methodology both in the presence and absence of dominant frequency (DF) gradients...
August 2016: Annals of Biomedical Engineering
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