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Gsk3 AND Gamma oscillations

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https://www.readbyqxmd.com/read/27582689/acute-ethanol-inhibition-of-%C3%AE-oscillations-is-mediated-by-akt-and-gsk3%C3%AE
#1
JianGang Wang, JingXi Zhao, ZhiHua Liu, FangLi Guo, Yali Wang, Xiaofang Wang, RuiLing Zhang, Martin Vreugdenhil, Chengbiao Lu
Hippocampal network oscillations at gamma band frequency (γ, 30-80 Hz) are closely associated with higher brain functions such as learning and memory. Acute ethanol exposure at intoxicating concentrations (≥50 mM) impairs cognitive function. This study aimed to determine the effects and the mechanisms of acute ethanol exposure on γ oscillations in an in vitro model. Ethanol (25-100 mM) suppressed kainate-induced γ oscillations in CA3 area of the rat hippocampal slices, in a concentration-dependent, reversible manner...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/19421138/fbw7-promotes-ubiquitin-dependent-degradation-of-c-myb-involvement-of-gsk3-mediated-phosphorylation-of-thr-572-in-mouse-c-myb
#2
K Kitagawa, Y Hiramatsu, C Uchida, T Isobe, T Hattori, T Oda, K Shibata, S Nakamura, A Kikuchi, M Kitagawa
Expression of oncoprotein c-Myb oscillates during hematopoiesis and hematological malignancies. Its quantity is not only regulated through transcriptional control but also through the ubiquitin-proteasome pathway, accompanied by phosphorylation, although the mechanisms are poorly understood. In this report, we tried to identify an E3 ubiquitin ligase, which targets c-Myb for ubiquitin-dependent degradation. We found that an F-box protein, Fbw7, interacted with c-Myb, which is mutated in numerous cancers. Fbw7 facilitated ubiquitylation and degradation of c-Myb in intact cells...
June 25, 2009: Oncogene
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