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Gsk3 AND Gamma oscillations

JianGang Wang, JingXi Zhao, ZhiHua Liu, FangLi Guo, Yali Wang, Xiaofang Wang, RuiLing Zhang, Martin Vreugdenhil, Chengbiao Lu
Hippocampal network oscillations at gamma band frequency (γ, 30-80 Hz) are closely associated with higher brain functions such as learning and memory. Acute ethanol exposure at intoxicating concentrations (≥50 mM) impairs cognitive function. This study aimed to determine the effects and the mechanisms of acute ethanol exposure on γ oscillations in an in vitro model. Ethanol (25-100 mM) suppressed kainate-induced γ oscillations in CA3 area of the rat hippocampal slices, in a concentration-dependent, reversible manner...
2016: Frontiers in Cellular Neuroscience
K Kitagawa, Y Hiramatsu, C Uchida, T Isobe, T Hattori, T Oda, K Shibata, S Nakamura, A Kikuchi, M Kitagawa
Expression of oncoprotein c-Myb oscillates during hematopoiesis and hematological malignancies. Its quantity is not only regulated through transcriptional control but also through the ubiquitin-proteasome pathway, accompanied by phosphorylation, although the mechanisms are poorly understood. In this report, we tried to identify an E3 ubiquitin ligase, which targets c-Myb for ubiquitin-dependent degradation. We found that an F-box protein, Fbw7, interacted with c-Myb, which is mutated in numerous cancers. Fbw7 facilitated ubiquitylation and degradation of c-Myb in intact cells...
June 25, 2009: Oncogene
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