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https://www.readbyqxmd.com/read/29738896/resistance-detected-in-pbmcs-predicts-virological-rebound-in-hiv-1-suppressed-patients-switching-treatment
#1
Daniele Armenia, Mauro Zaccarelli, Vanni Borghi, William Gennari, Domenico Di Carlo, Alberto Giannetti, Federica Forbici, Ada Bertoli, Caterina Gori, Lavinia Fabeni, Carmela Pinnetti, Raffaella Marocco, Alessandra Latini, Francesca Ceccherini-Silberstein, Claudio Maria Mastroianni, Cristina Mussini, Andrea Antinori, Carlo Federico Perno, Maria Mercedes Santoro
BACKGROUND: Genotypic resistance test (GRT) performed in peripheral blood mononuclear cells (PBMC) represents a chance to evaluate resistance in virologically suppressed HIV infected patients. OBJECTIVES: To evaluate the impact of baseline resistance detected through PBMC GRT on virological rebound after switching treatment. STUDY DESIGN: Baseline genotypic susceptibility scores (GSS) from PBMC GRT (DNA-GSS) and from previous cumulative plasma GRTs (when available, pRNA-GSS) were evaluated...
April 3, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29734096/does-recent-mania-affect-response-to-antidepressants-in-bipolar-disorder-a-re-analysis-of-step-bd-data
#2
Zahra Mousavi, Sheri Johnson, Descartes Li
BACKGROUND: One previous study suggested that the presence of a manic episode before bipolar depression is related to worse response to antidepressants. METHOD: To examine this effect in a larger sample, we used data from the large, multi-site STEP-BD study. We hypothesized that among persons treated with antidepressants for bipolar depression, manic or mixed episodes before depression onset (as compared to euthymia) would predict lower rate of recovery, more sustained depressive symptoms and higher rate of switching into mania/hypomania after antidepressant treatment of bipolar depression...
April 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29727386/entyvio-lengthen-dose-interval-study-lengthening-vedolizumab-dose-interval-and-the-risk-of-clinical-relapse-in-inflammatory-bowel-disease
#3
Webber Chan, Nicole Lynch, Peter Bampton, Jeff Chang, Alvin Chung, Timothy Florin, David J Hetzel, Simon Jakobovits, Gregory Moore, Paul Pavli, Graham Radford-Smith, Lena Thin, Brandon Baraty, Craig Haifer, Yunki Yau, Rupert W L Leong
BACKGROUND: Vedolizumab (VDZ), an α4β7 anti-integrin antibody, is efficacious in the induction and maintenance of remission in ulcerative colitis (UC) and Crohn's disease (CD). In the GEMINI long-term safety study, enrolled patients received 4-weekly VDZ. Upon completion, patients were switched to 8-weekly VDZ in Australia. The clinical success rate of treatment de-escalation for patients in remission on VDZ has not been described previously. AIM: To determine the proportion of patients who relapsed after switching from 4 to 8-weekly VDZ, the mean time to relapse, and the recapture rate when switching back to 8-weekly dosing...
April 30, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29703436/comparison-of-platelet-function-guided-versus-unguided-treatment-with-p2y12-inhibitors-in-patients-with-acute-myocardial-infarction-from-the-hungarian-myocardial-infarction-registry
#4
András Komócsi, Dániel Aradi, Tibor Szűk, Gergely György Nagy, Ebrahim Noori, Zoltán Ruzsa, Róbert G Kiss, Péter Andrássy, Lajos Nagy, Ferenc Tamás Nagy, Géza Lupkovics, Zsolt Kőszegi, Csaba András Dézsi, Előd Papp, Zsolt Molnár, Péter Kupó, Péter Ofner, Béla Merkely, András Jánosi
Evidence is conflicting regarding the clinical benefits of selecting P2Y12 inhibitors based on platelet function testing (PFT). Between March 1, 2013 and March 1, 2014, we collected clinical characteristics and platelet function data in a nationwide acute myocardial infarction (AMI) registry from 15 interventional cardiology centers in Hungary. The risk of all-cause mortality at 1 year were compared after propensity score (PS) matching between patients receiving PFT-guided and unguided P2Y12 -inhibitor therapies...
May 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29684577/predictors-of-switching-from-non-steroidal-anti-inflammatory-drugs-to-corticosteroids-in-patients-with-acute-pericarditis-and-impact-on-clinical-outcome
#5
George Lazaros, Alexios S Antonopoulos, Charalambos Vlachopoulos, Evangelos Oikonomou, Apostolos Karavidas, Christina Chrysohoou, Emilia Lazarou, Dimitrios Vassilopoulos, Massimo Imazio, Dimitris Tousoulis
BACKGROUND: Aspirin and non-steroidal anti-inflammatory drugs (A/NSAIDs) are the mainstay treatments for of acute pericarditis. We sought to identify factors predicting A/NSAIDs failure and switch to corticosteroid treatment (STCT) as well as the impact of STCT on pericarditis recurrence. METHODS: We enrolled 148 patients with acute pericarditis receiving A/NSAID (n=110) or corticosteroids (n=38) as first line treatment according to clinical indications. In case of poor response to A/NSAIDs (n=37), STCT was performed and factors contributing to such failure were explored...
April 20, 2018: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29676601/poor-cognitive-inhibition-predicts-rumination-about-insomnia-in-a-clinical-sample
#6
Andrea Ballesio, Cristina Ottaviani, Caterina Lombardo
OBJECTIVE/BACKGROUND: According to the Cognitive Model of Insomnia disorder, rumination about lack of sleep and its diurnal consequences plays a crucial role in maintaining insomnia. Consolidated evidence shows that rumination is related to poor executive functions, which are cognitive control processes impacted by insomnia. Despite this evidence, no studies so far investigated the relationship between executive functions and rumination in individuals with insomnia. The aim of this pilot study was to cover this gap by investigating whether poor executive functions are associated with rumination in a sample of individuals with a diagnosis of insomnia disorder...
April 20, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29674798/switching-of-antihypertensive-drugs-at-tertiary-care-government-hospital-hyderabad-india-a-cross-sectional-retrospective-investigation
#7
Varsha Varakantham, Ashok Kumar Kurakula Sailoo, Venkaiah Kodali, Dinesh Kumar Bharatraj
OBJECTIVE: Switching of antihypertensive drugs is attributed to uncontrolled blood pressure (BP) which imposes a great burden on health economics. But again, switching leads to accomplishment of the goal BP, thereby improving the health status. Such studies are well documented in developed nations but rarely reported in developing countries, especially in India. Therefore, the aim of this study was to evaluate various factors associated with switching of antihypertensive drugs. METHODS: A cross-sectional retrospective investigation was performed using a standardized schedule adapting the World Health Organization indicators for drug utilization in a tertiary care government hospital, Hyderabad, India...
November 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29668649/examining-parental-medication-adherence-as-a-predictor-of-child-medication-adherence-in-pediatric-anxiety-disorders
#8
Greta A Bushnell, M Alan Brookhart, Bradley N Gaynes, Scott N Compton, Stacie B Dusetzina, Til Stürmer
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are the recommended first-line pharmacotherapy for pediatric anxiety disorders but adherence remains difficult to predict. OBJECTIVES: To estimate SSRI adherence in children with anxiety disorders and determine if prior parental medication adherence is predictive of child high SSRI adherence. METHODS: We identified children (3-17 y) initiating SSRI treatment after an anxiety disorder diagnosis in a commercial claims database (2005-2014)...
April 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29658810/early-changes-in-ediary-copd-symptoms-predict-clinically-relevant-treatment-response-at-12-weeks-analysis-from-the-crystal-study
#9
Konstantinos Kostikas, Maryam Aalamian-Mattheis, Veronica Anna Pagano, Xavier Nunez, Robert Fogel, Francesco Patalano, Andreas Clemens
Early detection of treatment response is important in the long-term treatment and management of patients with chronic obstructive pulmonary disease (COPD). This analysis evaluated whether early improvement in symptoms, recorded in the first 7 or 14 days via an electronic diary (eDiary) compared with baseline, can predict clinically meaningful treatment responders at 12 weeks. CRYSTAL was a 12-week, randomized, open-label study that demonstrated the increased effectiveness of indacaterol/glycopyrronium (IND/GLY) or glycopyrronium (GLY), after a direct switch from on-going baseline therapies, in patients with symptomatic COPD and moderate airflow obstruction...
April 16, 2018: COPD
https://www.readbyqxmd.com/read/29627038/combining-clinical-and-magnetic-resonance-imaging-markers-enhances-prediction-of-12-year-employment-status-in-multiple-sclerosis-patients
#10
Lucie Kadrnozkova, Manuela Vaneckova, Lukas Sobisek, Barbora Benova, Karolina Kucerova, Jiri Motyl, Michaela Andelova, Klara Novotna, Jana Lizrova Preiningerova, Jan Krasensky, Eva Havrdova, Dana Horakova, Tomas Uher
BACKGROUND: Multiple sclerosis (MS) is frequently diagnosed in the most productive years of adulthood and is often associated with worsening employment status. However, reliable predictors of employment status change are lacking. OBJECTIVE: To identify early clinical and brain magnetic resonance imaging (MRI) markers of employment status worsening in MS patients at 12-year follow-up. METHODS: A total of 145 patients with early relapsing-remitting MS from the original Avonex-Steroids-Azathioprine (ASA) study were included in this prospective, longitudinal, observational cohort study...
May 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29609802/tracking-control-of-nonholonomic-mobile-agents-with-external-disturbances-and-input-delay
#11
Ahmadreza Jenabzadeh, Behrouz Safarinejadian
This paper investigates the tracking control problem of chained-form nonholonomic multiagent systems (MASs). In contrast to the existing works in which some algorithms have been designed for ideal conditions, the destructive factors including external disturbances and input delay are considered in the dynamics of the agents in this work. Two distributed controllers are proposed such that the states of the controlled agents can track the states of the target in the presence of external disturbances and input delay...
March 30, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29573320/efficacy-and-tolerability-of-lamivudine-plus-dolutegravir-as-a-switch-strategy-in-a-multicentre-cohort-of-patients-with-suppressed-hiv-1-replication
#12
A Borghetti, G Baldin, F Lombardi, A Ciccullo, A Capetti, S Rusconi, G Sterrantino, A Latini, M V Cossu, R Gagliardini, A De Luca, S Di Giambenedetto
OBJECTIVES: We evaluated the efficacy and tolerability of lamivudine + dolutegravir in a cohort of HIV-1 infected, treatment-experienced patients with undetectable HIV-RNA. METHODS: Time to treatment discontinuation (TD) and virological failure (VF) and their predictors were assessed in a multicenter cohort of HIV-1 infected patients, starting lamivudine + dolutegravir after reaching viral suppression. Secondary objective was the evaluation of changes in lipid profile, renal and immunological functions at week 48...
March 24, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29564716/the-postprandial-to-fasting-serum-c-peptide-ratio-is-a-predictor-of-response-to-basal-insulin-supported-oral-antidiabetic-drug-s-therapy-a-retrospective-analysis
#13
Pan-Wei Mu, De-Zhao Liu, Ying Lin, Dong Liu, Fan Zhang, Yong-Jun Zhang, Shuo Lin, Lin-Qin Wang, Man-Man Wang, Jiong Shu, Long-Yi Zeng, Yan-Ming Chen
INTRODUCTION: Basal insulin is widely recommended for the treatment of type 2 diabetes mellitus (T2DM) patients who are unable to achieve glycemic control with oral antidiabetic drug(s) (OADs). However, some patients are still unable to control their blood glucose levels even when on basal insulin-supported OAD(s) therapy (BOT). The aim of this study was to investigate the factor(s) predicting patient response to BOT. METHODS: A total of 212 patients with T2DM, ranging in age from 18 to 65 years, admitted to the university hospital of Sun Yat-sen University, Guangzhou, China, were enrolled in the study between January 2013 and July 2016...
March 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29554249/closing-in-phenomenon-in-huntington-s-disease-a-neuropsychological-marker-of-frontal-executive-dysfunction
#14
Natascia De Lucia, Silvio Peluso, Alessandro Roca, Cinzia Valeria Russo, Marco Massarelli, Giovanna De Michele, Luigi Di Maio, Elena Salvatore, Giuseppe De Michele
Objective: In visuo-constructional tasks, patients may reproduce drawings near-to or superimposed on a model, showing the so-called "Closing-in" (CI), often ascribed to a defect in inhibitory control. CI has been described in neurological conditions, but no studies have explored CI in Huntington's disease (HD), a neurodegenerative disorder often involving the frontal cortical-subcortical circuits. We searched for the occurrence of CI in HD patients and systematically investigated its correlates to find a clinical marker of the frontal/executive dysfunctions in the early examination of HD patients...
March 15, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29526801/bcl2-overexpressing-prostate-cancer-cells-rely-on-parp1-dependent-end-joining-and-are-sensitive-to-combined-parp-inhibitor-and-radiation-therapy
#15
Christoph Oing, Pierre Tennstedt, Ronald Simon, Jennifer Volquardsen, Kerstin Borgmann, Carsten Bokemeyer, Cordula Petersen, Ekkehard Dikomey, Kai Rothkamm, Wael Y Mansour
Here we report that BCL2 blocks DNA double strand break (DSB) repair via nonhomologous end-joining (NHEJ), through sequestration of KU80 protein outside the nucleus. We find that this effect is associated with a repair switch to the error-prone PARP1-dependent end-joining (PARP1-EJ). We present in-vitro proof-of-concept for therapeutic targeting of this switch using PARP inhibitor to specifically enhance the radiosensitivity of BCL2-overexpressing cells. Given its erroneous behavior, PARP1-EJ might allow for the accumulation of genetic alterations and tumor progression...
June 1, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29524759/clinical-outcomes-in-patients-with-relapsing-remitting-multiple-sclerosis-who-switch-from-natalizumab-to-delayed-release-dimethyl-fumarate-a-multicenter-retrospective-observational-study-strategy
#16
Stanley L Cohan, Harold Moses, Jonathan Calkwood, Carlo Tornatore, Chris LaGanke, Kyle E Smoot, Venkata Meka, Macaulay Okwuokenye, Christophe Hotermans, Jason P Mendoza, Monica K Mann, Leslie A Meltzer
BACKGROUND: Delayed-release dimethyl fumarate (DMF) may be a therapeutic option for patients with relapsing-remitting multiple sclerosis (RRMS) who are treated with natalizumab and require a change in therapy. However, there is limited information regarding predictors of favorable treatment outcomes in patients switching from natalizumab to DMF. Clinical practices and sequencing protocols vary. Herein, we present the clinical results, including annualized relapse rate (ARR) and risk of relapse, of a phase 4 retrospective observational study of patients with RRMS who switched from natalizumab to DMF in a community practice setting (STRATEGY)...
February 26, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29515363/fast-recognition-of-bci-inefficient-users-using-physiological-features-from-eeg-signals-a-screening-study-of-stroke-patients
#17
Xiaokang Shu, Shugeng Chen, Lin Yao, Xinjun Sheng, Dingguo Zhang, Ning Jiang, Jie Jia, Xiangyang Zhu
Motor imagery (MI) based brain-computer interface (BCI) has been developed as an alternative therapy for stroke rehabilitation. However, experimental evidence demonstrates that a significant portion (10-50%) of subjects are BCI-inefficient users (accuracy less than 70%). Thus, predicting BCI performance prior to clinical BCI usage would facilitate the selection of suitable end-users and improve the efficiency of stroke rehabilitation. In the current study, we proposed two physiological variables, i.e., laterality index (LI) and cortical activation strength (CAS), to predict MI-BCI performance...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29512096/predictive-value-of-cha2ds2-vasc-and-cha2ds2-vasc-hs-scores-for-failed-reperfusion-after-thrombolytic-therapy-in-patients-with-st-elevation-myocardial-%C3%A4-nfarction
#18
Salih Kilic, Umut Kocabas, Levent Hurkan Can, Oğuz Yavuzgil, Mustafa Çetin, Mehdi Zoghi
BACKGROUND: Thrombolytic therapy is recommended for patients with acute ST-segment elevation myocardial infarction (STEMI) who cannot undergo primary percutaneous coronary intervention within the first 120 min. The aim of this study wasz to demonstrate the value of CHA₂DS₂-VASc and CHA₂DS₂-VASc-HS scores in predicting failed reperfusion in STEMI patients treated with thrombolytic therapy. METHODS: A total of 537 consecutive patients were enrolled in the study; 139 had failed thrombolysis while the remaining 398 fulfilled the criteria for successful thrombolysis...
March 7, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29504060/author-correction-predictors-for-intracranial-hemorrhage-following-intravenous-thrombolysis-in-posterior-circulation-stroke
#19
Tomáš Dorňák, Michal Král, Zuzana Sedláčková, Daniel Šaňák, Eva Čecháková, Petra Divišová, Jana Zapletalová, Petr Kaňovský
In the original publication of the article, there was a switched order of author names.
March 5, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29492650/inter-and-intra-ventricular-dyssynchrony-in-the-systemic-right-ventricle-is-a-surrogate-marker-of-major-cardiac-events-in-mildly-symptomatic-patients
#20
Yumi Shiina, Kei Inai, Tatsunori Takahashi, Kota Taniguchi, Eri Watanabe, Kenji Fukushima, Koichiro Niwa, Michinobu Nagao
The aim of the study was to evaluate systemic right ventricular (RV) dyssynchrony in patients with congenitally corrected transposition of the great arteries (CCTGA) and transposition of the great arteries (TGA) with New York Heart Association functional class (NYHA FC) < III. We used cardiac magnetic resonance (CMR) to evaluate the dyssynchrony and assessed whether RV dyssynchrony can be predictive of major cardiac events in their early stages in these patients. We enrolled 71 consecutive, NYHA FC < III patients with systemic RV who underwent CMR between April 1995 and December 2016...
February 28, 2018: Heart and Vessels
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