Emanuele Cerulli Irelli, Enrico Cocchi, Alessandra Morano, Joanna Gesche, Roberto H Caraballo, Simona Lattanzi, Gionata Strigaro, Eleonora Rosati, Cecilia Catania, Edoardo Ferlazzo, Sara Casciato, Giancarlo Di Gennaro, Chiara Pizzanelli, Loretta Giuliano, Veronica Viola, Barbara Mostacci, Pietro Pignatta, Francesco Fortunato, Patrizia Pulitano, Chiara Panzini, Antonio Gambardella, Arife Çimen Atalar, Angelo Labate, Francesca Felicia Operto, Anna T Giallonardo, Betül B Baykan, Christoph P Beier, Carlo Di Bonaventura
BACKGROUND AND OBJECTIVES: To investigate the predictors of seizure recurrence in women of childbearing age with idiopathic generalized epilepsy (IGE) who switched from valproate (VPA) to alternative antiseizure medications (ASMs) and compare the effectiveness of levetiracetam (LEV) and lamotrigine (LTG) as VPA alternatives after switch. METHODS: This multicenter retrospective study included women of childbearing age diagnosed with IGE from 16 epilepsy centers. Study outcomes included worsening or recurrence of generalized tonic-clonic seizure (GTCS) at 12 months and 24 months after the switch from VPA to an alternative ASM...
May 2024: Neurology