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https://www.readbyqxmd.com/read/28346773/noninterventional-naturalistic-retrospective-study-to-describe-prescription-patterns-of-long-acting-injectable-antipsychotics-and-the-impact-of-introducing-a-new-atypical-antipsychotic-in-the-spanish-province-of-tarragona-catchment-area
#1
Ana M Gaviria, José Franco, Guillem Rico, Gerard Muntané, Cristina Sáez, Vanessa Sánchez-Gistau, Joan de Pablo, Elisabet Vilella
Background: We studied the patterns and predictors of long-acting injectable (LAI) antipsychotic (AP) use in the treatment of schizophrenia and the effect of introducing a new LAI (paliperidone palmitate [paliperidone-LAI]) in the Spanish province of Tarragona. Methods: This noninterventional, naturalistic, retrospective study included electronic medical record data from a large population-based database of 1,646 patients who were diagnosed with schizophrenia according to ICD-10 criteria and treated between January 2011 and December 2013...
March 23, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28336353/effectiveness-of-switching-smoking-cessation-medications-following-relapse
#2
Bryan W Heckman, K Michael Cummings, Karin A Kasza, Ron Borland, Jessica L Burris, Geoffrey T Fong, Ann McNeill, Matthew J Carpenter
INTRODUCTION: Nicotine dependence is a chronic disorder often characterized by multiple failed quit attempts (QAs). Yet, little is known about the sequence of methods used across multiple QAs or how this may impact future ability to abstain from smoking. This prospective cohort study examines the effectiveness of switching smoking-cessation medications (SCMs) across multiple QAs. METHODS: Adult smokers (aged ≥18 years) participating in International Tobacco Control surveys in the United Kingdom, U...
March 20, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28333346/the-impact-of-native-state-switching-on-protein-sequence-evolution
#3
Avital Sharir-Ivry, Yu Xia
For proteins with a single well-defined native state, protein 3Dstructure is a major determinant of sequence evolution. On the other hand, many proteins adopt multiple, distinct native structures under different conditions ("conformational switches"), yet the impact of such native state switching on protein evolution is not fully understood. Here, we performed a proteome-wide analysis of how protein structure impacts sequence evolution for protein conformational switches in Saccharomyces cerevisiae using pooled analysis of sites with similar packing or burial...
February 25, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28329178/intraoperative-coronary-revision-but-not-coronary-pattern-is-associated-with-mortality-after-arterial-switch-operation%C3%A2
#4
Matteo Trezzi, Angelo Polito, Antonio Albano, Sonia B Albanese, Enrico Cetrano, Adriano Carotti
OBJECTIVES: We sought to determine differences in baseline characteristics and clinical outcomes in a consecutive series of patients undergoing arterial switch operation (ASO), assessing the effect of coronary anatomy on postoperative mortality, both overall and adjusted for surgical era. METHODS: From January 2000 to May 2015, 283 consecutive patients underwent ASO for transposition of the great arteries. A total of 103 patients (36.4%) had an associated ventricular septal defect and 23 (8...
March 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28325614/gothic-aortic-arch-and-cardiac-mechanics-in-young-patients-after-arterial-switch-operation-for-d-transposition-of-the-great-arteries
#5
Giovanni Di Salvo, Ziad Bulbul, Valeria Pergola, Ziad Issa, Ghassan Siblini, Nisreen Muhanna, Domenico Galzerano, Bahaa Fadel, Mansour Al Joufan, Majid Al Fayyadh, Zohair Al Halees
BACKGROUND: In patients who have undergone arterial switch operation (ASO) for d-transposition of the great arteries a gothic aortic arch (GA) morphology has been found and it has been associated with abnormal aortic bio-elastic properties. HYPOTHESIS: GA is frequent in ASO patients and may have an impact on cardiac mechanics. Our study aims were to assess 1- the occurrence of GA in a large sample of patients after ASO; 2- the association between GA and aortic bio-elastic properties; and 3- the impact of GA on left ventricular (LV) function using speckle tracking echocardiography (STE)...
March 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28318330/changes-of-bone-mineral-density-and-serum-pentosidine-during-a-27-month-follow-up-of-monthly-minodronate-in-osteoporotic-patients
#6
Tsuyoshi Ohishi, Tomotada Fujita, Daisuke Suzuki, Tatsuya Nishida, Kazufumi Yamamoto, Ryo Okabayashi, Hiroki Ushirozako, Tomohiro Banno, Yukihiro Matsuyama
PURPOSE: Monthly regimen of minodronate for osteoporosis more than two years has not been reported yet. The aim of this study is to elucidate the effect of monthly minodronate (M-MIN) on bone mineral density (BMD) and serum pentosidine (Pen) during 27 months. MATERIALS AND METHODS: The study consisted of 52 newly treated patients (73.3 ± 8.8 years) (new group) and 47 patients (75.9 ± 9.5 years) who were switched from either alendronate or risedronate (switch group)...
March 20, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28315427/histologic-features-of-stromogenic-carcinoma-of-the-prostate-carcinomas-with-reactive-stroma-grade-3
#7
Andrea Diaz De Vivar, Mohammad Sayeeduddin, David Rowley, Antonio Cubilla, Brian Miles, Dov Kadmon, Gustavo Ayala
Prostatic carcinoma, like many other carcinomas, generates a stromal reaction. This phenomenon is well established in the scientific literature. The normal parenchymal smooth muscle phenotype switches to a myofibroblastic phenotype in response to the presence of cancer cells, with an expansion of the extracellular matrix compartment. The amount of reactive stroma is a predictor of biochemical recurrence in both radical prostatectomies and biopsies. It is a predictor of prostate cancer specific death in prostatectomies...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28303056/fixed-dose-combination-of-alogliptin-pioglitazone-improves-glycemic-control-in-japanese-patients-with-type-2-diabetes-mellitus-independent-of-body-mass-index
#8
Chie Aoki, Kunihiro Suzuki, Hisamoto Kuroda, Masaaki Sagara, Masanori Shimizu, Kikuo Kasai, Yoshimasa Aso
This study investigated the effects of switching from combination therapy with either alogliptin (Alo) or pioglitazone (Pio) to fixed-dose combination therapy (FDCT) with alogliptin and pioglitazone (Alo-Pio FDCT). The usefulness and efficacy of Alo-Pio FDCT were investigated. A total of 50 outpatients with type 2 diabetes mellitus (T2DM) treated with Alo and 47 outpatients with T2DM treated with Pio were switched to Alo-Pio FDCT, and its efficacy and usefulness were evaluated. Significant improvements were observed in hemoglobinA1c (HbA1c), alanine transaminase (ALT), and γ-glutamyl transpeptidase (GGT) levels after switching to Alo-Pio FDCT for 16 weeks in both groups...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28298195/role-of-systemic-inflammation-scores-for-prediction-of-clinical-outcomes-in-patients-treated-with-atazanavir-not-boosted-by-ritonavir-in-the-italian-master-cohort
#9
Maria Concetta Postorino, Mattia Prosperi, Emanuele Focà, Eugenia Quiros-Roldan, Elisa Di Filippo, Franco Maggiolo, Alberto Borghetti, Nicoletta Ladisa, Massimo Di Pietro, Andrea Gori, Laura Sighinolfi, Angelo Pan, Nicola Mazzini, Carlo Torti
BACKGROUND: Atazanavir (ATV) not boosted by ritonavir (uATV) has been frequently used in the past for switching combination antiretroviral therapy (cART). However, the clinical outcomes and predictors of such strategy are unknown. METHODS: An observational study was carried out on the Italian MASTER, selecting HIV infected patients on cART switching to an uATV-containing regimen. Baseline was set as the last visit before uATV initiation. In the primary analysis, a composite clinical end-point was defined as the first occurring of any condition among: liver, cardiovascular, kidney, diabetes, non AIDS related cancer or death events...
March 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28291052/first-line-antiretroviral-treatment-outcomes-and-durability-in-hiv-infectedchildren-treatedthrough-theuniversal-coverage-health-program-in-thailand
#10
Sirinya Teeraananchai, Torsak Bunupuradah, Thanyawee Puthanakit, Stephen J Kerr, Kiat Ruxrungtham, Suchada Chaivooth, Sorakij Bhakeecheep, Matthew G Law, Kulkanya Chokephaibulkit
BACKGROUND: We assessed the treatment outcomes on first-line antiretroviral therapy (ART), and factors associated with switching regimen in HIV-infected children treated through the universal coverage health program (UC) in Thailand. METHODS: Children aged <15 years at ART initiation who had been receiving ART for at least 6 months between 2008 and 2014 through UC were included in the analysis. The Kaplan-Meier method was used to estimate immunological recovery (IMR), immunologic failure (IMF) and virologic failure (VF)...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28290901/-ability-to-overcome-the-thrombocyte-resistance-to-acetylsalicylic-acid-in-patients-with-coronary-artery-disease-after-myocardial-revascularization-with-coronary-stenting
#11
I V Pershukov, S L Ostaschenko, T N Kuznetsova, S N Scherbo, Z A Karben, E V Sokryukina, A A Omarov, D M Ramazanov, N V Bosak, L V Shulzhenko, R K Kalmatov, T A Batyraliev, B A Sidorenko
Resistance to acetylsalicylic acid (ASA) in patients with coronary artery disease is a poor predictor for the development of atherothrombotic complications. In 277 patients with coronary artery disease suffered uncomplicated coronary angioplasty with stent implantation, we was estimated arachidon-induced platelet aggregation during treatment with acetylsalicylic acid by bedside VerifyNow Assay test at 28-90 days after the intervention. It was found that 18.9% of the 144 patients receiving a combination of ASA 75 mg with 15...
July 2016: Kardiologiia
https://www.readbyqxmd.com/read/28289278/cafeteria-diet-and-probiotic-therapy-cross-talk-among-memory-neuroplasticity-serotonin-receptors-and-gut-microbiota-in-the-rat
#12
J E Beilharz, N O Kaakoush, J Maniam, M J Morris
The western diet is known to have detrimental effects on cognition and the gut microbiota, but few studies have investigated how these may be related. Here, we examined whether a probiotic could prevent diet-induced memory deficits. Rats were pre-exposed to vehicle, low or high doses of VSL#3 for 2 weeks before half were switched from chow to a cafeteria diet (Caf) for 25 days; VSL#3 treatment continued until death. High-dose VSL#3 prevented the diet-induced memory deficits on the hippocampal-dependent place task, but the probiotic caused deficits on the perirhinal-dependent object task, irrespective of diet or dose...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28286925/cabozantinib-for-renal-cell-carcinoma-current-and-future-paradigms
#13
REVIEW
Ahmed Abdelaziz, Ulka Vaishampayan
Cabozantinib was approved by the FDA in April 2016 for the treatment of advanced renal cancer, pretreated with at least one prior antiangiogenic therapy. This is the first agent in the therapy of kidney cancer to show a statistically significant improvement in all three endpoints of clinical efficacy, response rate, progression free survival, and overall survival (OS), in a phase III randomized trial. The reporting of METEOR coincided with that of the Checkmate 025 study which randomized similarly eligible patients to receive nivolumab or everolimus 10 mg daily...
March 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28271234/impact-of-prior-biologic-use-on-persistence-of-treatment-in-patients-with-psoriatic-arthritis-enrolled-in-the-us-corrona-registry
#14
Leslie R Harrold, Bradley S Stolshek, Sabrina Rebello, David H Collier, Alex Mutebi, Sally W Wade, Wendi Malley, Jeffrey D Greenberg, Carol J Etzel
Psoriatic arthritis (PsA) is a chronic condition characterized by a diverse set of symptoms, from swollen joints to nail disease to skin disease. A variety of treatment options are available, including tumor necrosis factor inhibitors (TNFis). Little is known about treatment persistence in patients with PsA who initiate TNFi therapy, with and without prior biologic use. This study assessed persistence in these subgroups of patients with PsA and identified factors associated with persistence. This retrospective study utilized data from the Corrona registry of patients with PsA-with or without prior biologic experience-who initiated TNFi therapy between October 1, 2002, and March 21, 2013...
April 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28270790/consistently-showing-your-best-side-intra-individual-consistency-in-selfie-pose-orientation
#15
Annukka K Lindell
Painted and photographic portraits of others show an asymmetric bias: people favor their left cheek. Both experimental and database studies confirm that the left cheek bias extends to selfies. To date all such selfie studies have been cross-sectional; whether individual selfie-takers tend to consistently favor the same pose orientation, or switch between multiple poses, remains to be determined. The present study thus examined intra-individual consistency in selfie pose orientations. Two hundred selfie-taking participants (100 male and 100 female) were identified by searching #selfie on Instagram...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28264843/a-risk-score-for-fluconazole-failure-among-patients-with-candidemia
#16
Luis Ostrosky-Zeichner, Rachel Harrington, Nkechi Azie, Hongbo Yang, Nanxin Li, Jing Zhao, Valerie Koo, Eric Q Wu
Background: This study aimed to develop a prediction model to identify patients with candidemia at high risk of failing fluconazole.Methods: Adult patients in the US with candidemia who received fluconazole during hospitalization were selected from the Cerner Health Facts® database (04/2004-03/2013). Fluconazole failure was defined as switching/adding another antifungal, positive Candida culture ≥10 days after fluconazole initiation, or death during hospitalization. Patients were randomized into modeling and validation samples...
March 6, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28263145/early-and-midterm-results-of-the-arterial-switch-operation-a-9-year-single-center-experience
#17
Atakan Atalay, Ugur Gocen
BACKGROUND: The arterial switch operation (ASO) has become the surgical approach of choice for transposition of the great arteries. The aim of this paper was to describe the outcomes in patients who underwent arterial switch operation and to analyze the predictors of in-hospital mortality and further need for reoperation at a single-center institution. We reviewed our 9-year experience with arterial switch operation (ASO) for transposition of the great arteries (TGA) or Taussig-Bing anomaly (TBA) to assess the early and midterm outcomes...
February 28, 2017: Heart Surgery Forum
https://www.readbyqxmd.com/read/28255864/hyperinsulinemia-and-elevated-systolic-blood-pressure-independently-predict-white-matter-hyperintensities-with-associated-cognitive-decrement-in-the-middle-aged-offspring-of-dementia-patients
#18
Keith A Hawkins, Nazli Emadi, Godfrey D Pearlson, Anderson M Winkler, Beth Taylor, Latha Dulipsingh, Diana King, Brian Pittman, Karen Blank
Cerebrovascular disease is an independent risk factor for dementia that may also be synergistic with Alzheimer's disease. In recent years attention has switched from cerebral infarcts to microvascular disease as the primary cause of cerebrovascular cognitive decline, with damage to the white matter the primary mechanism. Uncertainties remain regarding the risks posed by different types vascular threat, the extent to which cerebrovascular damage occurs in middle age, and whether relatively "normal" amounts of white matter damage are accompanied by meaningful degrees of cognitive decline...
March 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28247605/-efficacy-of-adjuvant-endocrine-therapy-in-breast-cancer-patients-with-a-positive-to-negative-switch-of-hormone-receptor-status-after-neoadjuvant-chemotherapy
#19
Guangfa Xia, Juanying Zhu, Jun Yuan, Bo Cao, Jie Tang, Yiding Chen
Objective: To evaluate the efficacy of adjuvant endocrine therapy (AET) in breast cancer patients with a positive-to-negative switch of hormone receptor status after neoadjuvant chemotherapy (NAC). Methods: One hundred and six patients who presented with hormone receptor (HR)-positive breast cancer at diagnosis and turned to HR-negative after NAC during December 2000 and December 2013 in Jiaxing Maternity and Child Health Care Hospital were retrospectively identified. Kaplan-Meier analysis and log-rank test were used for univariate analyses of factors related to disease free survival (DFS) and overall survival (OS)...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28241886/comparison-of-associated-features-and-drug-treatment-between-co-occurring-unipolar-and-bipolar-disorders-in-depressed-eating-disorder-patients
#20
Mei-Chih Meg Tseng, Chin-Hao Chang, Shih-Cheng Liao, Hsi-Chung Chen
BACKGROUND: To examine the differences of associated characteristics and prescription drug use between co-occurring unipolar and bipolar disorders in patients with eating disorders (EDs). METHODS: Patients with EDs and major depressive episode (MDE) were recruited from psychiatric outpatient clinics. They were interviewed and completed self-administered measures assessing eating and general psychopathology. The prescribed drugs at the index outpatient visit were recorded...
February 27, 2017: BMC Psychiatry
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