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https://www.readbyqxmd.com/read/29337277/compensatory-dopaminergic-cholinergic-interactions-in-conflict-processing-evidence-from-patients-with-parkinson-s-disease
#1
REVIEW
Kamin Kim, Nicolaas I Bohnen, Martijn L T M Müller, Cindy Lustig
Executive functions are complex both in the cognitive operations involved and in the neural structures and functions that support those operations. This complexity makes executive function highly vulnerable to the detrimental effects of aging, brain injury, and disease, but may also open paths to compensation. Neural compensation is often used to explain findings of additional or altered patterns of brain activations by older adults or patient populations compared to young adults or healthy controls, especially when associated with relatively preserved performance...
January 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29317505/g%C3%AE-identity-dictates-efficacy-of-g%C3%AE-%C3%AE-signaling-and-macrophage-migration
#2
Kanishka Senarath, John L Payton, Dinesh Kankanamge, Praneeth Siripurapu, Mithila Tennakoon, Ajith Karunarathne
G protein βγ subunit (Gβγ) is a major signal transducer and controls processes ranging from cell migration to gene transcription. Despite having significant subtype heterogeneity and exhibiting diverse cell and tissue-specific expression levels, Gβγ is often considered a unified signaling entity with a defined functionality. However, the molecular and mechanistic basis of Gβγ's signaling specificity is unknown. Here, we demonstrate that Gγ subunits, bearing the sole plasma membrane (PM)-anchoring motif, control the PM affinity of Gβγ and thereby differentially modulate Gβγ effector signaling in a Gγ-specific manner...
January 9, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29304497/predictors-of-hematological-abnormalities-in-multiple-sclerosis-patients-treated-with-fingolimod-and-dimethyl-fumarate-and-impact-of-treatment-switch-on-lymphocyte-and-leukocyte-count
#3
M Baharnoori, C T Gonzalez, A Chua, C Diaz-Cruz, B C Healy, J Stankiewicz, H L Weiner, T Chitnis
BACKGROUND: There is limited data regarding the predictors of hematological abnormalities in multiple sclerosis (MS) patients treated with dimethyl fumarate (DMF) or fingolimod (FNG), and the impact of treatment switch on lymphocyte and leukocyte count METHODS: We identified 405 patients on DMF and 300 patients on FNG (treatment duration: at least 12 month) within a large prospective study of MS patients conducted at the Partners MS Center, Brigham and Women's Hospital (CLIMB study) between Jan 2011 to Feb 2016...
December 14, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29290438/genetic-parameters-of-milk-production-traits-in-response-to-a-short-once-daily-milking-period-in-crossbred-holstein-%C3%A3-normande-dairy-cows
#4
C Charton, J Guinard-Flament, R Lefebvre, S Barbey, Y Gallard, D Boichard, H Larroque
Despite its potential utility for predicting cows' milk yield responses to once-daily milking (ODM), the genetic basis of cow milk trait responses to ODM has been scarcely if ever described in the literature, especially for short ODM periods. This study set out to (1) estimate the genetic determinism of milk yield and composition during a 3-wk ODM period, (2) estimate the genetic determinism of milk yield responses (i.e., milk yield loss upon switching cows to ODM and milk yield recovery upon switching them back to twice-daily milking; TDM), and (3) seek predictors of milk yield responses to ODM, in particular using the first day of ODM...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29220530/impaired-lipolysis-diminished-fat-oxidation-and-metabolic-inflexibility-in-obese-girls-with-polycystic-ovary-syndrome
#5
Joon Young Kim, Hala Tfayli, Sara F Michaliszyn, Silva Arslanian
CONTEXT: Metabolic flexibility reflects the ability to switch from lipid to carbohydrate oxidation during insulin stimulation manifested in increased respiratory quotient (RQ). Despite insulin resistance in glucose metabolism in PCOS women and adolescents, little is known about adipose tissue metabolism and metabolic flexibility. OBJECTIVE: To investigate whole-body lipolysis, substrate oxidation and metabolic flexibility in obese PCOS vs. non-PCOS girls. PATIENTS/DESIGN: Twenty-one obese (BMI 32...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29202547/predictors-of-glycemic-response-and-change-in-hba1c-following-newly-initiated-basal-insulin-among-insulin-na%C3%A3-ve-adults-with-type-2-diabetes
#6
Mojtaba Malek, Rokhsareh Aghili, Ameneh Ebrahim Valojerdi, Mohammad Ebrahim Khamseh
This sub-analysis of the Iran-AFECT study was to determine the baseline characteristics are predicting the likelihood of attainment of HbA1c goal and changing in HbA1c after initiation of basal insulin glargine in insulin naïve people with type 2 diabetes not adequately controlled with oral glucose-lowering drugs. Iran-AFECT was a 24-week, prospective, multicenter, observational study of people with type 2 diabetes initiated or switched to insulin glargine. In this sub-analysis, we included all insulin naïve people...
September 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29202455/a-simple-clinically-relevant-therapeutic-vaccine-shows-long-term-protection-in-an-aggressive-delayed-treatment-b-lymphoma-model
#7
Pallab Pradhan, Jardin Leleux, Jiaying Liu, Krishnendu Roy
Despite initial remission after successful treatments, B lymphoma patients often encounter relapses and resistance causing high mortality. Thus, there is a need to develop therapies that prevent relapse by providing long-term protection and, ultimately, lead to functional cure. In this study, our goal was to develop a simple, clinically relevant, and easily translatable therapeutic vaccine that provides durable immune protection against aggressive B cell lymphoma and identify critical immune biomarkers that are predictive of long-term survival...
November 16, 2017: JCI Insight
https://www.readbyqxmd.com/read/29197759/source-identification-of-human-exposure-to-lead-in-nine-cree-nations-from-quebec-canada-eeyou-istchee-territory
#8
Eric N Liberda, Leonard J S Tsuji, Ian D Martin, Pierre Ayotte, Elizabeth Robinson, Eric Dewailly, Evert Nieboer
While policies to decrease lead in the environment have been implemented to reduce human exposure to various lead sources, the use of lead ammunition to harvest wild game may continue to contribute significantly to human blood lead levels (BLLs). As part of a multi-community environment-and-health study, BLLs representing all age groups were evaluated in the nine Cree Nations located in the James and Hudson Bay regions of Quebec, Canada. Personal, market food, traditional food and 24-h recall questionnaires were administered...
November 30, 2017: Environmental Research
https://www.readbyqxmd.com/read/29153060/using-pyruvate-kinase-as-a-predictor-for-patient-with-endometrial-cancer-having-complex-hyperplasia-with-atypia-to-prevent-hysterectomy-and-preserve-fertility-retrospective-immunohistochemical-study
#9
Susan Hosseini Nasab, Neda Jooya, Aryan Esmaeili, Neda Zarrin Khameh, Concepcion Diaz-Arrastia, Mazdak Momeni
OBJECTIVES: To explore whether the metabolic switches proceed or succeed the histological changes in precancerous lesions. To validate pyruvate kinase isoform 1 (PKM1) and pyruvate kinase isoform 2 (PKM2) as a histological biomarker to predict the progression of endometrial hyperplasia into invasive cancer status. METHODS: The records of 56 patients with a primary diagnosis of complex hyperplasia with atypia after endometrial biopsy were selected and analyzed retrospectively...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29148592/oral-anticoagulants-in-german-nursing-home-residents-drug-use-patterns-and-predictors-for-treatment-choice
#10
Kathrin Jobski, Falk Hoffmann, Stefan Herget-Rosenthal, Michael Dörks
AIMS: Information on utilization of oral anticoagulants (OACs) in nursing homes is scarce. This study aimed to (i) describe OAC use in German nursing home residents, (ii) examine factors influencing whether treatment is initiated with vitamin K antagonists (VKAs) or non-VKA oral anticoagulants (NOACs) and (iii) assess which conditions predict switching to NOAC instead of continuing VKA. METHODS: Using claims data (2010-2014), we studied a cohort of new nursing home residents aged ≥ 65 years receiving OAC...
November 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29148403/treatment-patterns-in-rheumatoid-arthritis-after-discontinuation-of-methotrexate-data-from-the-ontario-best-practices-research-initiative-obri
#11
Janet E Pope, Emmanouil Rampakakis, Mohammad Movahedi, Angela Cesta, Xiuying Li, Sandra Couto, John S Sampalis, Claire Bombardier
OBJECTIVES: In active rheumatoid arthritis (RA) patients with inadequate response to methotrexate (MTX), guidelines support adding or switching to another conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) and/or a biologic DMARD (bDMARD). The purpose of this analysis was to describe treatment practices in routine care and to evaluate determinants of regimen selection after MTX discontinuation. METHODS: Biologic-naïve patients in the Ontario Best Practice Research Initiatives registry discontinuing MTX due to primary/secondary failure, adverse events, or patient/physician decision were included...
October 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29145512/impact-of-the-surgical-strategy-on-the-incidence-of-c5-nerve-root-palsy-in-decompressive-cervical-surgery
#12
Theresa Krätzig, Malte Mohme, Klaus C Mende, Sven O Eicker, Frank W Floeth
OBJECTIVE: Our aim was to identify the impact of different surgical strategies on the incidence of C5 palsy. BACKGROUND: Degenerative cervical spinal stenosis is a steadily increasing morbidity in the ageing population. Postoperative C5 nerve root palsy is a common complication with severe impact on the patients´ quality of life. METHODS: We identified 1708 consecutive patients who underwent cervical decompression surgery due to degenerative changes...
2017: PloS One
https://www.readbyqxmd.com/read/29134435/plant-phenology-supports-the-multi-emergence-hypothesis-for-ebola-spillover-events
#13
Katharina C Wollenberg Valero, Raphael D Isokpehi, Noah E Douglas, Seenith Sivasundaram, Brianna Johnson, Kiara Wootson, Ayana McGill
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored. Filoviridae viruses have a wide range of natural hosts and are unstable once outside hosts. Spillover events, which involve the physical transfer of viral particles across species, could therefore be directly promoted by conditions of host ecology and environment. In this report, we outline a proof of concept that temporal fluctuations of a set of ecological and environmental variables describing the dynamics of the host ecosystem are able to predict such events of Ebola virus spillover to humans and animals...
November 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#14
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29082448/aflibercept-in-diabetic-macular-edema-refractory-to-previous-bevacizumab-outcomes-and-predictors-of-success
#15
Rita Laiginhas, Marta Inês Silva, Vitor Rosas, Susana Penas, Vitor Adriano Fernandes, Amândio Rocha-Sousa, Ângela Carneiro, Fernando Falcão-Reis, Manuel Sousa Falcão
PURPOSE: To evaluate functional and anatomical outcomes after aflibercept in patients with diabetic macular edema (DME) with poor response to bevacizumab. METHODS: We retrospectively reviewed patients with DME recalcitrant to bevacizumab who were switched to aflibercept between January and December 2015. All patients had a minimal follow-up of three months before the conversion and underwent at least three injections of bevacizumab. Functional outcome consisted in best corrected visual acuity (VA)...
October 29, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29080680/differential-drug-survival-of-second-line-biologic-therapies-in-patients-with-psoriasis-observational-cohort-study-from-the-british-association-of-dermatologists-biologic-interventions-register-badbir
#16
Ireny Y K Iskandar, Richard B Warren, Mark Lunt, Kayleigh J Mason, Ian Evans, Kathleen McElhone, Catherine H Smith, Nick J Reynolds, Darren M Ashcroft, Christopher E M Griffiths
Little is known about the drug survival of second-line biologic therapies for psoriasis in routine clinical practice. We assessed drug survival of second-line biologic therapies and estimated the risk of recurrent discontinuation due to adverse events (AEs) or ineffectiveness in psoriasis patients who had failed a first biologic and switched to a second in a large, multi-centre pharmacovigilance registry (n=1239; adalimumab,538; etanercept,104; ustekinumab,597). The overall drug survival rate in the first year after switching was 77% (95% confidence interval (CI): 74%-79%), falling to 58% (55%-61%) in the third year...
October 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29077973/prevalence-and-predictors-of-tumour-necrosis-factor-inhibitor-persistence-in-psoriatic-arthritis
#17
Carmel Stober, Weiyu Ye, Thushyanthan Guruparan, Eiphyu Htut, Gavin Clunie, Deepak Jadon
Objectives: To evaluate TNF-α inhibitor (TNFi) persistence when used as first- or second-line biologic therapy for the management of PsA, and to determine baseline clinical and laboratory parameters associated with TNFi persistence. Methods: A retrospective single-centre cohort study was performed on all patients with PsA initiated on TNFi therapy between 2003 and 2015. Demographic, clinical and laboratory characteristics were compared with TNFi persistence, using Kaplan-Meier survival and Cox proportional hazards models...
January 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29071119/switching-biological-disease-modifying-antirheumatic-drugs-in-patients-with-axial-spondyloarthritis-results-from-a-systematic-literature-review
#18
Victoria Navarro-Compán, Chamaida Plasencia-Rodríguez, Eugenio de Miguel, Petra Diaz Del Campo, Alejandro Balsa, Jordi Gratacós
OBJECTIVES: First, to investigate if switching biological disease-modifying antirheumatic drugs (bDMARDs) after the failure to prior bDMARD is efficacious in patients with axial spondyloarthritis (axSpA). Second, to evaluate the influence on this efficacy of (1) the reason to discontinue prior tumour necrosis factor inhibitor (TNFi), (2) changing the type of TNFi and (3) changing the target. METHODS: A systematic literature review until January 2017 was performed using Medline, EMBASE and Cochrane databases...
2017: RMD Open
https://www.readbyqxmd.com/read/29069303/a-prospective-genome-wide-study-of-prostate-cancer-metastases-reveals-association-of-wnt-pathway-activation-and-increased-cell-cycle-proliferation-with-primary-resistance-to-abiraterone-acetate-prednisone
#19
L Wang, S M Dehm, D W Hillman, H Sicotte, W Tan, M Gormley, V Bhargava, R Jimenez, F Xie, P Yin, S Qin, F Quevedo, B A Costello, H C Pitot, T Ho, A H Bryce, Z Ye, Y Li, P Eiken, P T Vedell, P Barman, B P McMenomy, T D Atwell, R E Carlson, M Ellingson, B Eckloff, R Qin, F Ou, S N Hart, H Huang, J Jen, E D Wieben, K R Kalari, R M Weinshilboum, L Wang, M Kohli
Background: Genomic aberrations have been identified in metastatic castration-resistant prostate cancer (mCRPC), but molecular predictors of resistance to abiraterone acetate/prednisone (AA/P) treatment are not known. Patients and Methods: In a prospective clinical trial, mCRPC patients underwent whole exome sequencing (n = 82) and RNA-sequencing (n = 75) of metastatic biopsies before initiating AA/P with the objective of identifying genomic alterations associated with resistance to AA/P...
October 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29063217/quetiapine-induced-hypomania-and-its-association-with-quetiapine-norquetiapine-plasma-concentrations-a-case-series-of-bipolar-type-2-patients
#20
C Rovera, C M Esposito, V Ciappolino, D Cattaneo, S Baldelli, E Clementi, A C Altamura, M Buoli
International guidelines consider quetiapine at medium doses (300-400 mg/day) as valid options for the treatment of bipolar depression for the supposed lower risk of a switch to hypomania/mania than antidepressants. Norquetiapine is an active metabolite with antidepressant action. We describe three cases of induced hypomania in bipolar type 2 subjects who received quetiapine extended-release monotherapy (300 mg/day) for a mild/moderate major depressive episode. Quetiapine and norquetiapine plasma concentrations were measured after 1 week of treatment...
October 23, 2017: Drug Safety—Case Reports
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