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https://www.readbyqxmd.com/read/29153060/using-pyruvate-kinase-as-a-predictor-for-patient-with-endometrial-cancer-having-complex-hyperplasia-with-atypia-to-prevent-hysterectomy-and-preserve-fertility-retrospective-immunohistochemical-study
#1
Susan Hosseini Nasab, Neda Jooya, Aryan Esmaeili, Neda Zarrin Khameh, Concepcion Diaz-Arrastia, Mazdak Momeni
OBJECTIVES: To explore whether the metabolic switches proceed or succeed the histological changes in precancerous lesions. To validate pyruvate kinase isoform 1 (PKM1) and pyruvate kinase isoform 2 (PKM2) as a histological biomarker to predict the progression of endometrial hyperplasia into invasive cancer status. METHODS: The records of 56 patients with a primary diagnosis of complex hyperplasia with atypia after endometrial biopsy were selected and analyzed retrospectively...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29148592/oral-anticoagulants-in-german-nursing-home-residents-drug-use-patterns-and-predictors-for-treatment-choice
#2
Kathrin Jobski, Falk Hoffmann, Stefan Herget-Rosenthal, Michael Dörks
AIMS: Information on utilization of oral anticoagulants (OACs) in nursing homes is scarce. This study aimed to (i) describe OAC use in German nursing home residents, (ii) examine factors influencing whether treatment is initiated with vitamin K antagonists (VKAs) or non-VKA oral anticoagulants (NOACs) and (iii) assess which conditions predict switching to NOAC instead of continuing VKA. METHODS: Using claims data (2010-2014), we studied a cohort of new nursing home residents aged ≥ 65 years receiving OAC...
November 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29148403/treatment-patterns-in-rheumatoid-arthritis-after-discontinuation-of-methotrexate-data-from-the-ontario-best-practices-research-initiative-obri
#3
Janet E Pope, Emmanouil Rampakakis, Mohammad Movahedi, Angela Cesta, Xiuying Li, Sandra Couto, John S Sampalis, Claire Bombardier
OBJECTIVES: In active rheumatoid arthritis (RA) patients with inadequate response to methotrexate (MTX), guidelines support adding or switching to another conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) and/or a biologic DMARD (bDMARD). The purpose of this analysis was to describe treatment practices in routine care and to evaluate determinants of regimen selection after MTX discontinuation. METHODS: Biologic-naïve patients in the Ontario Best Practice Research Initiatives registry discontinuing MTX due to primary/secondary failure, adverse events, or patient/physician decision were included...
October 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29145512/impact-of-the-surgical-strategy-on-the-incidence-of-c5-nerve-root-palsy-in-decompressive-cervical-surgery
#4
Theresa Krätzig, Malte Mohme, Klaus C Mende, Sven O Eicker, Frank W Floeth
OBJECTIVE: Our aim was to identify the impact of different surgical strategies on the incidence of C5 palsy. BACKGROUND: Degenerative cervical spinal stenosis is a steadily increasing morbidity in the ageing population. Postoperative C5 nerve root palsy is a common complication with severe impact on the patients´ quality of life. METHODS: We identified 1708 consecutive patients who underwent cervical decompression surgery due to degenerative changes...
2017: PloS One
https://www.readbyqxmd.com/read/29134435/plant-phenology-supports-the-multi-emergence-hypothesis-for-ebola-spillover-events
#5
Katharina C Wollenberg Valero, Raphael D Isokpehi, Noah E Douglas, Seenith Sivasundaram, Brianna Johnson, Kiara Wootson, Ayana McGill
Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored. Filoviridae viruses have a wide range of natural hosts and are unstable once outside hosts. Spillover events, which involve the physical transfer of viral particles across species, could therefore be directly promoted by conditions of host ecology and environment. In this report, we outline a proof of concept that temporal fluctuations of a set of ecological and environmental variables describing the dynamics of the host ecosystem are able to predict such events of Ebola virus spillover to humans and animals...
November 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/29130626/age-related-macular-degeneration-using-morphological-predictors-to-modify-current-treatment-protocols
#6
REVIEW
Mohammed Ashraf, Ahmed Souka, Ron A Adelman
To assess predictors of treatment response in neovascular age-related macular degeneration (AMD) in an attempt to develop a patient-centric treatment algorithm. We conducted a systematic search using PubMed, EMBASE and Web of Science for prognostic indicators/predictive factors with the key words: 'age related macular degeneration', 'neovascular AMD', 'choroidal neovascular membrane (CNV)', 'anti-vascular endothelial growth factor (anti-VEGF)', 'aflibercept', 'ranibizumab', 'bevacizumab', 'randomized clinical trials', 'post-hoc', 'prognostic', 'predictive', 'response' 'injection frequency, 'treat and extend (TAE), 'pro re nata (PRN)', 'bi-monthly' and 'quarterly'...
November 11, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29082448/aflibercept-in-diabetic-macular-edema-refractory-to-previous-bevacizumab-outcomes-and-predictors-of-success
#7
Rita Laiginhas, Marta Inês Silva, Vitor Rosas, Susana Penas, Vitor Adriano Fernandes, Amândio Rocha-Sousa, Ângela Carneiro, Fernando Falcão-Reis, Manuel Sousa Falcão
PURPOSE: To evaluate functional and anatomical outcomes after aflibercept in patients with diabetic macular edema (DME) with poor response to bevacizumab. METHODS: We retrospectively reviewed patients with DME recalcitrant to bevacizumab who were switched to aflibercept between January and December 2015. All patients had a minimal follow-up of three months before the conversion and underwent at least three injections of bevacizumab. Functional outcome consisted in best corrected visual acuity (VA)...
October 29, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29080680/differential-drug-survival-of-second-line-biologic-therapies-in-patients-with-psoriasis-observational-cohort-study-from-the-british-association-of-dermatologists-biologic-interventions-register-badbir
#8
Ireny Y K Iskandar, Richard B Warren, Mark Lunt, Kayleigh J Mason, Ian Evans, Kathleen McElhone, Catherine H Smith, Nick J Reynolds, Darren M Ashcroft, Christopher E M Griffiths
Little is known about the drug survival of second-line biologic therapies for psoriasis in routine clinical practice. We assessed drug survival of second-line biologic therapies and estimated the risk of recurrent discontinuation due to adverse events (AEs) or ineffectiveness in psoriasis patients who had failed a first biologic and switched to a second in a large, multi-centre pharmacovigilance registry (n=1239; adalimumab,538; etanercept,104; ustekinumab,597). The overall drug survival rate in the first year after switching was 77% (95% confidence interval (CI): 74%-79%), falling to 58% (55%-61%) in the third year...
October 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29077973/prevalence-and-predictors-of-tumour-necrosis-factor-inhibitor-persistence-in-psoriatic-arthritis
#9
Carmel Stober, Weiyu Ye, Thushyanthan Guruparan, Eiphyu Htut, Gavin Clunie, Deepak Jadon
Objectives: To evaluate TNF-α inhibitor (TNFi) persistence when used as first- or second-line biologic therapy for the management of PsA, and to determine baseline clinical and laboratory parameters associated with TNFi persistence. Methods: A retrospective single-centre cohort study was performed on all patients with PsA initiated on TNFi therapy between 2003 and 2015. Demographic, clinical and laboratory characteristics were compared with TNFi persistence, using Kaplan-Meier survival and Cox proportional hazards models...
October 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29071119/switching-biological-disease-modifying-antirheumatic-drugs-in-patients-with-axial-spondyloarthritis-results-from-a-systematic-literature-review
#10
Victoria Navarro-Compán, Chamaida Plasencia-Rodríguez, Eugenio de Miguel, Petra Diaz Del Campo, Alejandro Balsa, Jordi Gratacós
OBJECTIVES: First, to investigate if switching biological disease-modifying antirheumatic drugs (bDMARDs) after the failure to prior bDMARD is efficacious in patients with axial spondyloarthritis (axSpA). Second, to evaluate the influence on this efficacy of (1) the reason to discontinue prior tumour necrosis factor inhibitor (TNFi), (2) changing the type of TNFi and (3) changing the target. METHODS: A systematic literature review until January 2017 was performed using Medline, EMBASE and Cochrane databases...
2017: RMD Open
https://www.readbyqxmd.com/read/29069303/a-prospective-genome-wide-study-of-prostate-cancer-metastases-reveals-association-of-wnt-pathway-activation-and-increased-cell-cycle-proliferation-with-primary-resistance-to-abiraterone-acetate-prednisone
#11
L Wang, S M Dehm, D W Hillman, H Sicotte, W Tan, M Gormley, V Bhargava, R Jimenez, F Xie, P Yin, S Qin, F Quevedo, B A Costello, H C Pitot, T Ho, A H Bryce, Z Ye, Y Li, P Eiken, P T Vedell, P Barman, B P McMenomy, T D Atwell, R E Carlson, M Ellingson, B Eckloff, R Qin, F Ou, S N Hart, H Huang, J Jen, E D Wieben, K R Kalari, R M Weinshilboum, L Wang, M Kohli
Background: Genomic aberrations have been identified in metastatic castration-resistant prostate cancer (mCRPC), but molecular predictors of resistance to abiraterone acetate/prednisone (AA/P) treatment are not known. Patients and Methods: In a prospective clinical trial, mCRPC patients underwent whole exome sequencing (n = 82) and RNA-sequencing (n = 75) of metastatic biopsies before initiating AA/P with the objective of identifying genomic alterations associated with resistance to AA/P...
October 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29063217/quetiapine-induced-hypomania-and-its-association-with-quetiapine-norquetiapine-plasma-concentrations-a-case-series-of-bipolar-type-2-patients
#12
C Rovera, C M Esposito, V Ciappolino, D Cattaneo, S Baldelli, E Clementi, A C Altamura, M Buoli
International guidelines consider quetiapine at medium doses (300-400 mg/day) as valid options for the treatment of bipolar depression for the supposed lower risk of a switch to hypomania/mania than antidepressants. Norquetiapine is an active metabolite with antidepressant action. We describe three cases of induced hypomania in bipolar type 2 subjects who received quetiapine extended-release monotherapy (300 mg/day) for a mild/moderate major depressive episode. Quetiapine and norquetiapine plasma concentrations were measured after 1 week of treatment...
October 23, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29058952/increased-arterial-stiffness-in-children-with-congenital-heart-disease
#13
Anna-Luisa Häcker, Barbara Reiner, Renate Oberhoffer, Alfred Hager, Peter Ewert, Jan Müller
Objective Central systolic blood pressure (SBP) is a measure of arterial stiffness and strongly associated with atherosclerosis and end-organ damage. It is a stronger predictor of cardiovascular events and all-cause mortality than peripheral SBP. In particular, for children with congenital heart disease, a higher central SBP might impose a greater threat of cardiac damage. The aim of the study was to analyse and compare central SBP in children with congenital heart disease and in healthy counterparts. Patients and methods Central SBP was measured using an oscillometric method in 417 children (38...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29033017/neurocognitive-and-psychological-outcomes-in-adults-with-dextro-transposition-of-the-great-arteries-corrected-by-the-arterial-switch-operation
#14
Leïla Kasmi, Johanna Calderon, Michèle Montreuil, Nikoletta Geronikola, Virginie Lambert, Emrè Belli, Damien Bonnet, David Kalfa
BACKGROUND: Neurodevelopmental impairments have frequently been described in children and adolescents with dextro-transposition of the great arteries (d-TGA). The arterial switch operation (ASO) to correct d-TGA has been used for more than 30 years, and more than 90% of these patients now reach adulthood. However, very little is known about their long-term functional outcomes. The present study investigated neurocognitive outcomes and the prevalence of psychiatric disorders in adults with d-TGA corrected by ASO...
October 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29030806/palliative-care-in-the-management-of-patients-with-advanced-heart-failure
#15
Susan E Lowey
Globally, there are 18-million individuals living with heart failure, a disease that is responsible for 12-15 million office visits and 6.5 million inpatient hospitalizations each year. As HF becomes advanced or end-stage, patients often live in a cycle of frequent transitions between care settings, and with unmet needs, including distress from inadequately managed symptoms. Prognostication in patients with heart failure can be challenging due to the unpredictable exacerbating-remitting illness trajectory that is associated with this progressive disease...
October 14, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29029201/a-comprehensive-comparison-of-quantifications-of-intraindividual-variability-in-response-times-a-measurement-burst-approach
#16
Robert S Stawski, Stuart W S MacDonald, Paul W H Brewster, Elizabeth Munoz, Eric S Cerino, Drew W R Halliday
Objectives: To formally identify and contrast the most commonly-employed quantifications of response time inconsistency (RTI) and elucidate their utility for understanding within-person (WP) and between-person (BP) variation in cognitive function with increasing age. Method: Using two measurement burst studies of cognitive aging, we systematically identified and computed five RTI quantifications from select disciplines to examine: (a) correlations among RTI quantifications; (b) the distribution of BP and WP variation in RTI; and (c) the comparability of RTI quantifications for predicting attention switching...
September 28, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28984052/patterns-of-long-term-use-of-non-vitamin-k-antagonist-oral-anticoagulants-for-non-valvular-atrial-fibrillation-quebec-observational-study
#17
Antonios Douros, Christel Renoux, Janie Coulombe, Samy Suissa
PURPOSE: Studies on long-term utilization of non-vitamin K antagonist oral anticoagulants (NOACs) in non-valvular atrial fibrillation (NVAF) are scarce. We evaluated predictors of use and long-term persistence of NOACs in a real-world setting. METHODS: This population-based cohort study used the computerized databases of the Canadian Province of Quebec's health insurance. Patients with a first NVAF diagnosis from 2011 until 2014 were included. A logistic regression model yielded adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for predictors of treatment initiation with NOACs versus VKAs...
October 6, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28969448/high-prevalence-of-drug-resistance-mutations-among-patients-failing-first-line-antiretroviral-therapy-and-predictors-of-virological-response-24-weeks-after-switch-to-second-line-therapy-in-s%C3%A3-o-paulo-state-brazil
#18
Elaine Monteiro Matsuda, Luana Portes Coelho, Giselle Romero, Monica Jaques Moraes, Giselle Ibette Silva Lopez Lopes, Karen Mirna Loro Morejon, Alexandre Ely Campeas, Gabriela Bastos Cabral, Luis Fm Brigido, Salvage Therapy Working Group
INTRODUCTION: Universal antiretroviral treatment with sustained viral suppression benefits patients and reduces HIV transmission. Effectiveness of therapy may be limited by antiretroviral drug resistance. Information on the resistance profile at treatment failure and its impact on antiretroviral drugs may subsidize subsequent treatment strategies. METHODS: Partial pol sequences from 319 patients failing first-line therapy were analyzed for resistance associated mutations (RAMs) and HIV subtype...
October 2, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28963913/trends-in-prescribing-systemic-treatment-and-overall-survival-for-non-small-cell-lung-cancer-stage-iiib-iv-in-the-netherlands-2008-2012
#19
Bas J M Peters, Christine M Cramer-Vd Welle, Arthur A J Smit, Franz M N H Schramel, Ewoudt M W van de Garde
BACKGROUND: The present study aims to give a detailed overview of day-to-day practice in the systemic treatment of NSCLC stage IIIB/IV and its clinical outcomes in six large teaching hospitals in the Netherlands in the period 2008-2012. METHODS: A retrospective observational cohort study was conducted in the Care for Outcome registry. Patients diagnosed with stage IIIB/IV NSCLC were included and drug data were collected. Outcomes included percentage of patients treated with systemic treatment, percentage of different first line treatment options, survival, and number and percentage of switches, dose reductions (<80% of the initial dose), and early discontinuation (<4 cycles)...
September 27, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28953325/multicentre-analysis-of-second-line-antiretroviral-treatment-in-hiv-infected-children-adolescents-at-high-risk-of-failure
#20
Ragna S Boerma, Torsak Bunupuradah, Dorothy Dow, Joseph Fokam, Azar Kariminia, Dara Lehman, Cissy Kityo, Victor Musiime, Paul Palumbo, Annelot Schoffelen, Sam Sophan, Brian Zanoni, Tobias F Rinke de Wit, Job C J Calis, Kim C E Sigaloff
INTRODUCTION: The number of HIV-infected children and adolescents requiring second-line antiretroviral treatment (ART) is increasing in low- and middle-income countries (LMIC). However, the effectiveness of paediatric second-line ART and potential risk factors for virologic failure are poorly characterized. We performed an aggregate analysis of second-line ART outcomes for children and assessed the need for paediatric third-line ART. METHODS: We performed a multicentre analysis by systematically reviewing the literature to identify cohorts of children and adolescents receiving second-line ART in LMIC, contacting the corresponding study groups and including patient-level data on virologic and clinical outcomes...
September 15, 2017: Journal of the International AIDS Society
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